Research ArticleAccepted Article
Association between enthesitis and health-related quality of life in psoriatic arthritis in anti-TNF-naïve patients from two Phase 3 ustekinumab trials
Iain B. McInnes, Lluis Puig, Alice B. Gottlieb, Christopher Ritchlin, Michael Song, Yin You, Shelly Kafka, G. James Morgan, Proton Rahman and Arthur Kavanaugh on behalf of the PSUMMIT 1 and 2 Study
The Journal of Rheumatology April 2019, jrheum.180792; DOI: https://doi.org/10.3899/jrheum.180792
Iain B. McInnes
From the University of Glasgow, Institute of Infection Immunity & Inflammation, Glasgow Biomedical Research Centre, Glasgow, Scotland; Hospital de la Santa Creu i Sant Pau, Universitat Autònoma de Barcelona, Barcelona, Spain; Department of Dermatology, Icahn School of Medicine at Mt Sinai, New York, NY; University of Rochester, Medical Center, Rochester, NY; Janssen Research & Development, LLC., Spring House, PA; Janssen Scientific Affairs, LLC, Horsham, PA; Memorial University, NL, Canada; University of California-San Diego, CA. This study was funded by Janssen Research & Development, LLC. Address correspondence to Iain McInnes, Institute of Infection Immunity & Inflammation, Glasgow Biomedical Research Centre, Level 4, 120 University Place, Glasgow, Scotland, G12 8TA, United Kingdom. E-mail: Iain.McInnes@glasgow.ac.uk
Lluis Puig
From the University of Glasgow, Institute of Infection Immunity & Inflammation, Glasgow Biomedical Research Centre, Glasgow, Scotland; Hospital de la Santa Creu i Sant Pau, Universitat Autònoma de Barcelona, Barcelona, Spain; Department of Dermatology, Icahn School of Medicine at Mt Sinai, New York, NY; University of Rochester, Medical Center, Rochester, NY; Janssen Research & Development, LLC., Spring House, PA; Janssen Scientific Affairs, LLC, Horsham, PA; Memorial University, NL, Canada; University of California-San Diego, CA. This study was funded by Janssen Research & Development, LLC. Address correspondence to Iain McInnes, Institute of Infection Immunity & Inflammation, Glasgow Biomedical Research Centre, Level 4, 120 University Place, Glasgow, Scotland, G12 8TA, United Kingdom. E-mail: Iain.McInnes@glasgow.ac.uk
Alice B. Gottlieb
From the University of Glasgow, Institute of Infection Immunity & Inflammation, Glasgow Biomedical Research Centre, Glasgow, Scotland; Hospital de la Santa Creu i Sant Pau, Universitat Autònoma de Barcelona, Barcelona, Spain; Department of Dermatology, Icahn School of Medicine at Mt Sinai, New York, NY; University of Rochester, Medical Center, Rochester, NY; Janssen Research & Development, LLC., Spring House, PA; Janssen Scientific Affairs, LLC, Horsham, PA; Memorial University, NL, Canada; University of California-San Diego, CA. This study was funded by Janssen Research & Development, LLC. Address correspondence to Iain McInnes, Institute of Infection Immunity & Inflammation, Glasgow Biomedical Research Centre, Level 4, 120 University Place, Glasgow, Scotland, G12 8TA, United Kingdom. E-mail: Iain.McInnes@glasgow.ac.uk
Christopher Ritchlin
From the University of Glasgow, Institute of Infection Immunity & Inflammation, Glasgow Biomedical Research Centre, Glasgow, Scotland; Hospital de la Santa Creu i Sant Pau, Universitat Autònoma de Barcelona, Barcelona, Spain; Department of Dermatology, Icahn School of Medicine at Mt Sinai, New York, NY; University of Rochester, Medical Center, Rochester, NY; Janssen Research & Development, LLC., Spring House, PA; Janssen Scientific Affairs, LLC, Horsham, PA; Memorial University, NL, Canada; University of California-San Diego, CA. This study was funded by Janssen Research & Development, LLC. Address correspondence to Iain McInnes, Institute of Infection Immunity & Inflammation, Glasgow Biomedical Research Centre, Level 4, 120 University Place, Glasgow, Scotland, G12 8TA, United Kingdom. E-mail: Iain.McInnes@glasgow.ac.uk
Michael Song
From the University of Glasgow, Institute of Infection Immunity & Inflammation, Glasgow Biomedical Research Centre, Glasgow, Scotland; Hospital de la Santa Creu i Sant Pau, Universitat Autònoma de Barcelona, Barcelona, Spain; Department of Dermatology, Icahn School of Medicine at Mt Sinai, New York, NY; University of Rochester, Medical Center, Rochester, NY; Janssen Research & Development, LLC., Spring House, PA; Janssen Scientific Affairs, LLC, Horsham, PA; Memorial University, NL, Canada; University of California-San Diego, CA. This study was funded by Janssen Research & Development, LLC. Address correspondence to Iain McInnes, Institute of Infection Immunity & Inflammation, Glasgow Biomedical Research Centre, Level 4, 120 University Place, Glasgow, Scotland, G12 8TA, United Kingdom. E-mail: Iain.McInnes@glasgow.ac.uk
Yin You
From the University of Glasgow, Institute of Infection Immunity & Inflammation, Glasgow Biomedical Research Centre, Glasgow, Scotland; Hospital de la Santa Creu i Sant Pau, Universitat Autònoma de Barcelona, Barcelona, Spain; Department of Dermatology, Icahn School of Medicine at Mt Sinai, New York, NY; University of Rochester, Medical Center, Rochester, NY; Janssen Research & Development, LLC., Spring House, PA; Janssen Scientific Affairs, LLC, Horsham, PA; Memorial University, NL, Canada; University of California-San Diego, CA. This study was funded by Janssen Research & Development, LLC. Address correspondence to Iain McInnes, Institute of Infection Immunity & Inflammation, Glasgow Biomedical Research Centre, Level 4, 120 University Place, Glasgow, Scotland, G12 8TA, United Kingdom. E-mail: Iain.McInnes@glasgow.ac.uk
Shelly Kafka
From the University of Glasgow, Institute of Infection Immunity & Inflammation, Glasgow Biomedical Research Centre, Glasgow, Scotland; Hospital de la Santa Creu i Sant Pau, Universitat Autònoma de Barcelona, Barcelona, Spain; Department of Dermatology, Icahn School of Medicine at Mt Sinai, New York, NY; University of Rochester, Medical Center, Rochester, NY; Janssen Research & Development, LLC., Spring House, PA; Janssen Scientific Affairs, LLC, Horsham, PA; Memorial University, NL, Canada; University of California-San Diego, CA. This study was funded by Janssen Research & Development, LLC. Address correspondence to Iain McInnes, Institute of Infection Immunity & Inflammation, Glasgow Biomedical Research Centre, Level 4, 120 University Place, Glasgow, Scotland, G12 8TA, United Kingdom. E-mail: Iain.McInnes@glasgow.ac.uk
G. James Morgan
From the University of Glasgow, Institute of Infection Immunity & Inflammation, Glasgow Biomedical Research Centre, Glasgow, Scotland; Hospital de la Santa Creu i Sant Pau, Universitat Autònoma de Barcelona, Barcelona, Spain; Department of Dermatology, Icahn School of Medicine at Mt Sinai, New York, NY; University of Rochester, Medical Center, Rochester, NY; Janssen Research & Development, LLC., Spring House, PA; Janssen Scientific Affairs, LLC, Horsham, PA; Memorial University, NL, Canada; University of California-San Diego, CA. This study was funded by Janssen Research & Development, LLC. Address correspondence to Iain McInnes, Institute of Infection Immunity & Inflammation, Glasgow Biomedical Research Centre, Level 4, 120 University Place, Glasgow, Scotland, G12 8TA, United Kingdom. E-mail: Iain.McInnes@glasgow.ac.uk
Proton Rahman
From the University of Glasgow, Institute of Infection Immunity & Inflammation, Glasgow Biomedical Research Centre, Glasgow, Scotland; Hospital de la Santa Creu i Sant Pau, Universitat Autònoma de Barcelona, Barcelona, Spain; Department of Dermatology, Icahn School of Medicine at Mt Sinai, New York, NY; University of Rochester, Medical Center, Rochester, NY; Janssen Research & Development, LLC., Spring House, PA; Janssen Scientific Affairs, LLC, Horsham, PA; Memorial University, NL, Canada; University of California-San Diego, CA. This study was funded by Janssen Research & Development, LLC. Address correspondence to Iain McInnes, Institute of Infection Immunity & Inflammation, Glasgow Biomedical Research Centre, Level 4, 120 University Place, Glasgow, Scotland, G12 8TA, United Kingdom. E-mail: Iain.McInnes@glasgow.ac.uk
Arthur Kavanaugh
From the University of Glasgow, Institute of Infection Immunity & Inflammation, Glasgow Biomedical Research Centre, Glasgow, Scotland; Hospital de la Santa Creu i Sant Pau, Universitat Autònoma de Barcelona, Barcelona, Spain; Department of Dermatology, Icahn School of Medicine at Mt Sinai, New York, NY; University of Rochester, Medical Center, Rochester, NY; Janssen Research & Development, LLC., Spring House, PA; Janssen Scientific Affairs, LLC, Horsham, PA; Memorial University, NL, Canada; University of California-San Diego, CA. This study was funded by Janssen Research & Development, LLC. Address correspondence to Iain McInnes, Institute of Infection Immunity & Inflammation, Glasgow Biomedical Research Centre, Level 4, 120 University Place, Glasgow, Scotland, G12 8TA, United Kingdom. E-mail: Iain.McInnes@glasgow.ac.uk
Abstract
Objective Evaluate enthesitis, physical function, and HRQoL among anti-TNF-naïve PsA patients.
Methods In PSUMMIT 1 and 2, PsA patients were randomized to placebo or ustekinumab 45mg or 90mg. Enthesitis was assessed at weeks 0 and 24 (MASES). Assessments included HAQ-DI, SF-36 PCS/MCS, and ACR20.
Results At week24, 21 had worsened enthesitis, 158 had improved enthesitis, and 412 had unchanged enthesitis. Improved enthesitis was associated with improvements in HAQ-DI and SF-36 MCS. Results were similar for ACR20 responders and nonresponders.
Conclusion Improvement in enthesitis at week24 was associated with improvements in physical function/HRQoL regardless of ACR20 response.
In this issue
The Journal of Rheumatology
Vol. 51, Issue 4
1 Apr 2024
Accepted manuscript
Association between enthesitis and health-related quality of life in psoriatic arthritis in anti-TNF-naïve patients from two Phase 3 ustekinumab trials
Iain B. McInnes, Lluis Puig, Alice B. Gottlieb, Christopher Ritchlin, Michael Song, Yin You, Shelly Kafka, G. James Morgan, Proton Rahman, Arthur Kavanaugh
The Journal of Rheumatology Apr 2019, jrheum.180792; DOI: 10.3899/jrheum.180792
Accepted manuscript
Association between enthesitis and health-related quality of life in psoriatic arthritis in anti-TNF-naïve patients from two Phase 3 ustekinumab trials
Iain B. McInnes, Lluis Puig, Alice B. Gottlieb, Christopher Ritchlin, Michael Song, Yin You, Shelly Kafka, G. James Morgan, Proton Rahman, Arthur Kavanaugh
The Journal of Rheumatology Apr 2019, jrheum.180792; DOI: 10.3899/jrheum.180792