Skip to main content

Main menu

  • Home
  • Content
    • First Release
    • Current
    • Archives
    • Collections
    • AV Rheum
    • Forum
  • Resources
    • Guide for Authors
    • Submit Manuscript
    • Author Payment
    • Reviewers
    • Advertisers
    • Classified Ads
    • Reprints and Translations
    • Permissions
    • Meetings
    • FAQ
    • Policies
  • Subscribers
    • Subscription Information
    • Purchase Subscription
    • Your Account
    • Terms and Conditions
  • About Us
    • About Us
    • Editorial Board
    • Letter from the Editor
    • Duncan A. Gordon Award
    • Accessibility
  • Contact Us
  • JRheum Supplements
  • Publisher Services

User menu

  • My Cart
  • Log In

Search

  • Advanced search
The Journal of Rheumatology
  • JRheum Supplements
  • Publisher Services
  • My Cart
  • Log In
The Journal of Rheumatology

Advanced Search

  • Home
  • Content
    • First Release
    • Current
    • Archives
    • Collections
    • AV Rheum
    • Forum
  • Resources
    • Guide for Authors
    • Submit Manuscript
    • Author Payment
    • Reviewers
    • Advertisers
    • Classified Ads
    • Reprints and Translations
    • Permissions
    • Meetings
    • FAQ
    • Policies
  • Subscribers
    • Subscription Information
    • Purchase Subscription
    • Your Account
    • Terms and Conditions
  • About Us
    • About Us
    • Editorial Board
    • Letter from the Editor
    • Duncan A. Gordon Award
    • Accessibility
  • Contact Us
  • Follow jrheum on Twitter
  • Visit jrheum on Facebook
  • Follow jrheum on LinkedIn
  • Follow jrheum on RSS
Research ArticleArticle

Nailfold Capillaroscopy Characteristics of Antisynthetase Syndrome and Possible Clinical Associations: Results of a Multicenter International Study

Marco Sebastiani, Konstantinos Triantafyllias, Andreina Manfredi, Miguel Angel González-Gay, Natalia Palmou-Fontana, Giulia Cassone, Ulrich Drott, Christiane Delbrück, Jorge Rojas-Serrano, Chiara Bertolazzi, Laura Nuño, Margherita Giannini, Florenzo Iannone, Esther F. Vicente, Santos Castañeda, Albert Selva-O’Callaghan, Ernesto Trallero Araguas, Giacomo Emmi, Annamaria Iuliano, Jutta Bauhammer, Nikolaus Miehle, Simone Parisi, Lorenzo Cavagna, Veronica Codullo, Carlomaurizio Montecucco, Francisco Javier Lopez-Longo, Julia Martínez-Barrio, Juan Carlos Nieto-González, Silvia Vichi, Marco Confalonieri, Paola Tomietto, Raoul Bergner, Alberto Sulli, Francesco Bonella, Federica Furini, Carlo Alberto Scirè, Alessandra Bortoluzzi, Christof Specker, Simone Barsotti, Rossella Neri, Marta Mosca, Marzia Caproni, Julia Weinmann-Menke, Andreas Schwarting, Vanessa Smith and Maurizio Cutolo on behalf of the American and European Network of Antisynthetase Syndrome Collaborative Group
The Journal of Rheumatology November 2018, jrheum.180355; DOI: https://doi.org/10.3899/jrheum.180355
Marco Sebastiani
From the Rheumatology Unit, Azienda Policlinico of Modena, University of Modena and Reggio Emilia, Modena, Italy; ACURA Rheumatology Center, Bad Kreuznach, Germany; Rheumatology Division, Hospital Universitario Marqués de Valdecilla, IDiVAL, University of Cantabria, Santander, Spain; Rheumatology Division, University Hospital of Frankfurt, Frankfurt, Germany; Interstitial Lung Disease and Rheumatology Unit, Instituto Nacional de Enfermedades Respiratorias, Ismael Cosío Villegas, Mexico City, Mexico; Servicio de Reumatología, Hospital Universitario La Paz, Madrid, Spain; Interdisciplinary Department of Medicine (DIM), Rheumatology Unit, University of Bari, Bari, Italy; Rheumatology Department, Hospital Universitario de la Princesa, Instituto de Investigación Sanitaria (IIS) Princesa, Madrid; Unidad de Enfermedades Autoinmunes Sistémicas, Servicio de Medicina Interna, Universidad Autonoma de Barcelona, on behalf of the GEAS group, Barcelona, Spain; Department of Experimental and Clinical Medicine, and Department of Medical and Surgical Critical Care, Section of Dermatology, University of Florence, Florence; Unità Operativa Complessa (UOC) Reumatologia, Ospedale San Camillo-Forlanini, Rome; ACURA Centre for Rheumatic Diseases, Baden-Baden, Germany; Rheumatology Department, Città Della Salute e della Scienza, Torino; Division of Rheumatology, University and Institute for Research and Health Care (IRCCS) Policlinico S. Matteo Foundation, Pavia, Italy; Servicio de Reumatología, Hospital General Universitario Gregorio Marañón, Madrid, Spain; Dermatology Clinic, University Hospital of Trieste; Department of Pneumology and Respiratory Intermediate Care Unit, University Hospital of Cattinara, Trieste; Rheumatology Unit, Azienda Ospedaliero-Universitaria Ospedali Riuniti di Trieste, Trieste, Italy; Medizinische Klinik A, Klinikum der Stadt, Ludwigshafen, Germany; Research Laboratory and Academic Division of Clinical Rheumatology, Department of Internal Medicine, University of Genoa, San Martino Polyclinic Hospital IRCCS Genoa, Genoa, Italy; Interstitial and Rare Lung Disease Unit, Ruhrlandklinik University Hospital, University of Duisburg-Essen, Essen, Germany; UOC Reumatologia, Azienda Ospedaliero Universitaria S. Anna, University of Ferrara, Italy; Department for Rheumatology and Clinical Immunology, St. Josef Krankenhaus, University Clinic, Essen, Germany; Division of Rheumatology, Department of Clinical and Experimental Medicine, University of Pisa, Pisa; Department of Internal Medicine, Rheumatology and Clinical Immunology, University Hospital Johannes-Gutenberg, Mainz, Germany; University of Ghent, Ghent University Hospital, Ghent, Belgium. M. Sebastiani, MD, Rheumatology Unit, Azienda Policlinico of Modena, University of Modena and Reggio Emilia; A. Manfredi, MD, Rheumatology Unit, Azienda Policlinico of Modena, University of Modena and Reggio Emilia; G. Cassone, MD, Rheumatology Unit, Azienda Policlinico of Modena, University of Modena and Reggio Emilia; K. Triantafyllias, MD, ACURA Rheumatology Center; A. Schwarting, MD, Professor, ACURA Rheumatology Center; M.A. González-Gay, MD, Professor, Rheumatology Division, Hospital Universitario Marqués de Valdecilla, IDiVAL, University of Cantabria; N. Palmou-Fontana, MD, Rheumatology Division, Hospital Universitario Marqués de Valdecilla, IDiVAL, University of Cantabria; U. Drott, MD, Rheumatology Division, University Hospital of Frankfurt; C. Delbrück, MD, Rheumatology Division, University Hospital of Frankfurt; J. Rojas-Serrano, MD, Professor, Interstitial Lung Disease and Rheumatology Unit, Instituto Nacional de Enfermedades Respiratorias, Ismael Cosío Villegas; C. Bertolazzi, MD, Interstitial Lung Disease and Rheumatology Unit, Instituto Nacional de Enfermedades Respiratorias, Ismael Cosío Villegas; L. Nuño, MD, Servicio de Reumatología, Hospital Universitario La Paz; M. Giannini, MD, DIM, Rheumatology Unit, University of Bari; F. Iannone, MD, Professor, DIM, Rheumatology Unit, University of Bari; E.F. Vicente, MD, Rheumatology Department, Hospital Universitario de la Princesa, IIS Princesa; S. Castañeda, MD, Professor, Rheumatology Department, Hospital Universitario de la Princesa, IIS Princesa; A. Selva-O’Callaghan, MD, Professor, Unidad de Enfermedades Autoinmunes Sistémicas, Servicio de Medicina Interna, Universidad Autonoma de Barcelona, on behalf of the GEAS group; E. Trallero Araguas, MD, Unidad de Enfermedades Autoinmunes Sistémicas, Servicio de Medicina Interna, Universidad Autonoma de Barcelona, on behalf of the GEAS group; G. Emmi, MD, Department of Experimental and Clinical Medicine, University of Florence; A. Iuliano, MD, UOC Reumatologia, Ospedale San Camillo-Forlanini; J. Bauhammer, MD, ACURA Centre for Rheumatic Diseases; N. Miehle MD, ACURA Centre for Rheumatic Diseases; S. Parisi, MD, Rheumatology Department, Città Della Salute e della Scienza; L. Cavagna, MD, Division of Rheumatology, University and IRCCS Policlinico S. Matteo Foundation; V. Codullo, MD, Division of Rheumatology, University and IRCCS Policlinico S. Matteo Foundation; C. Montecucco, MD, Professor, Division of Rheumatology, University and IRCCS Policlinico S. Matteo Foundation; F.J. Lopez-Longo, MD, Servicio de Reumatología, Hospital General Universitario Gregorio Marañón; J. Martínez-Barrio, MD, Servicio de Reumatología, Hospital General Universitario Gregorio Marañón; J.C. Nieto-González, MD, Servicio de Reumatología, Hospital General Universitario Gregorio Marañón; S. Vichi, MD, Dermatology Clinic, University Hospital of Trieste; M. Confalonieri, MD, Department of Pneumology and Respiratory Intermediate Care Unit, University Hospital of Cattinara; P. Tomietto MD, Rheumatology Unit, Azienda Ospedaliero-Universitaria Ospedali Riuniti; R. Bergner, MD, Professor, Medizinische Klinik A, Klinikum der Stadt; A. Sulli, MD, Professor, Research Laboratory and Academic Division of Clinical Rheumatology, Department of Internal Medicine, University of Genoa, San Martino Polyclinic Hospital IRCCS Genoa; M. Cutolo, MD, Professor, Research Laboratory and Academic Division of Clinical Rheumatology, Department of Internal Medicine, University of Genoa, San Martino Polyclinic Hospital IRCCS Genoa; F. Bonella, MD, Interstitial and Rare Lung Disease Unit, Ruhrlandklinik University Hospital, University of Duisburg-Essen; F. Furini, MD, UOC Reumatologia, Azienda Ospedaliero Universitaria S. Anna, University of Ferrara; C.A. Scirè, MD, Associate Professor, UOC Reumatologia, Azienda Ospedaliero Universitaria S. Anna, University of Ferrara; A. Bortoluzzi, MD, UOC Reumatologia, Azienda Ospedaliero Universitaria S. Anna, University of Ferrara; C. Specker, MD, Professor, Department for Rheumatology and Clinical Immunology, St. Josef Krankenhaus, University Clinic; S. Barsotti, MD, Division of Rheumatology, Department of Clinical and Experimental Medicine, University of Pisa; R. Neri, MD, Division of Rheumatology, Department of Clinical and Experimental Medicine, University of Pisa; M. Mosca, MD, Professor, Division of Rheumatology, Department of Clinical and Experimental Medicine, University of Pisa; M. Caproni, MD, Department of Medical and Surgical Critical Care, Section of Dermatology, University of Florence; J. Weinmann-Menke, MD, Department of Internal Medicine, Rheumatology and Clinical Immunology, University Hospital Johannes-Gutenberg; A. Schwarting, MD, Professor, Department of Internal Medicine, Rheumatology and Clinical Immunology, University Hospital Johannes-Gutenberg; V. Smith, MD, Professor, University of Ghent, Ghent University Hospital. Dr. Sebastiani and Dr. Triantafyllias contributed equally to this article. Address correspondence to Dr. K. Triantafyllias, ACURA Rheumatology Center, Bad Kreuznach, Germany. E-mail: ktriantafyllias@gmail.com. Accepted for publication August 13, 2018.
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Konstantinos Triantafyllias
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Andreina Manfredi
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Miguel Angel González-Gay
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Natalia Palmou-Fontana
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Giulia Cassone
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Ulrich Drott
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Christiane Delbrück
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Jorge Rojas-Serrano
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Chiara Bertolazzi
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Laura Nuño
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Margherita Giannini
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Florenzo Iannone
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Esther F. Vicente
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Santos Castañeda
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Albert Selva-O’Callaghan
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Ernesto Trallero Araguas
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Giacomo Emmi
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Annamaria Iuliano
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Jutta Bauhammer
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Nikolaus Miehle
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Simone Parisi
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Lorenzo Cavagna
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Veronica Codullo
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Carlomaurizio Montecucco
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Francisco Javier Lopez-Longo
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Julia Martínez-Barrio
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Juan Carlos Nieto-González
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Silvia Vichi
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Marco Confalonieri
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Paola Tomietto
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Raoul Bergner
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Alberto Sulli
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Francesco Bonella
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Federica Furini
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Carlo Alberto Scirè
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Alessandra Bortoluzzi
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Christof Specker
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Simone Barsotti
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Rossella Neri
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Marta Mosca
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Marzia Caproni
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Julia Weinmann-Menke
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Andreas Schwarting
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Vanessa Smith
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Maurizio Cutolo
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • Article
  • Figures & Data
  • Supplemental
  • References
  • Info & Metrics
  • PDF
  • eLetters
PreviousNext
Loading

Abstract

Objective To describe nailfold videocapillaroscopy (NVC) features of patients with antisynthetase syndrome (AS) and to investigate possible correlations with clinical and serological features of the disease.

Methods We retrospectively analyzed NVC images of 190 patients with AS [females/males 3.63, mean age 49.7 ± 12.8 yrs, median disease duration 53.7 mos (interquartile range 82), 133 anti-Jo1 and 57 non–anti-Jo1-positive patients]. For each patient, we examined number of capillaries, giant capillaries, microhemorrhages, avascular areas, ramified capillaries, and the presence of systemic sclerosis (SSc)-like pattern. Finally, we correlated NVC features with clinical and serological findings of patients with AS. Concomitantly, a historical cohort of 75 patients with antinuclear antibody–negative primary Raynaud phenomenon (RP) and longterm followup was used as a control group (female/male ratio 4.13/1, mean age 53.9 ± 17.6 yrs) for NVC measures.

Results NVC abnormalities were observed in 62.1% of AS patients compared with 29.3% of primary RP group (p < 0.001). An SSc-like pattern was detected in 67 patients (35.3%) and it was associated with anti-Jo1 antibodies (p = 0.002) and also with a longer disease duration (p = 0.004). Interestingly, there was no significant correlation between the presence of SSc-like pattern and RP, and only 47% of patients with SSc-like pattern had RP.

Conclusion NVC abnormalities are commonly observed in AS, independently from the occurrence of RP. The presence of an SSc-like pattern could allow identification of a more defined AS subtype, and prospective studies could confirm the association with clinical and serological features of AS.

Log in using your username and password

Forgot your user name or password?

Purchase access

You may purchase access to this article. This will require you to create an account if you don't already have one.
PreviousNext
Back to top

In this issue

The Journal of Rheumatology
Vol. 46, Issue 2
1 Feb 2019
  • Table of Contents
  • Table of Contents (PDF)
  • Index by Author
  • Editorial Board (PDF)
Download PDF
Article Alerts
Sign In to Email Alerts with your Email Address
Email Article

Thank you for your interest in spreading the word about The Journal of Rheumatology.

NOTE: We only request your email address so that the person you are recommending the page to knows that you wanted them to see it, and that it is not junk mail. We do not capture any email address.

Enter multiple addresses on separate lines or separate them with commas.
Nailfold Capillaroscopy Characteristics of Antisynthetase Syndrome and Possible Clinical Associations: Results of a Multicenter International Study
(Your Name) has forwarded a page to you from The Journal of Rheumatology
(Your Name) thought you would like to see this page from the The Journal of Rheumatology web site.
Citation Tools
Nailfold Capillaroscopy Characteristics of Antisynthetase Syndrome and Possible Clinical Associations: Results of a Multicenter International Study
Marco Sebastiani, Konstantinos Triantafyllias, Andreina Manfredi, Miguel Angel González-Gay, Natalia Palmou-Fontana, Giulia Cassone, Ulrich Drott, Christiane Delbrück, Jorge Rojas-Serrano, Chiara Bertolazzi, Laura Nuño, Margherita Giannini, Florenzo Iannone, Esther F. Vicente, Santos Castañeda, Albert Selva-O’Callaghan, Ernesto Trallero Araguas, Giacomo Emmi, Annamaria Iuliano, Jutta Bauhammer, Nikolaus Miehle, Simone Parisi, Lorenzo Cavagna, Veronica Codullo, Carlomaurizio Montecucco, Francisco Javier Lopez-Longo, Julia Martínez-Barrio, Juan Carlos Nieto-González, Silvia Vichi, Marco Confalonieri, Paola Tomietto, Raoul Bergner, Alberto Sulli, Francesco Bonella, Federica Furini, Carlo Alberto Scirè, Alessandra Bortoluzzi, Christof Specker, Simone Barsotti, Rossella Neri, Marta Mosca, Marzia Caproni, Julia Weinmann-Menke, Andreas Schwarting, Vanessa Smith, Maurizio Cutolo
The Journal of Rheumatology Nov 2018, jrheum.180355; DOI: 10.3899/jrheum.180355

Citation Manager Formats

  • BibTeX
  • Bookends
  • EasyBib
  • EndNote (tagged)
  • EndNote 8 (xml)
  • Medlars
  • Mendeley
  • Papers
  • RefWorks Tagged
  • Ref Manager
  • RIS
  • Zotero

 Request Permissions

Share
Nailfold Capillaroscopy Characteristics of Antisynthetase Syndrome and Possible Clinical Associations: Results of a Multicenter International Study
Marco Sebastiani, Konstantinos Triantafyllias, Andreina Manfredi, Miguel Angel González-Gay, Natalia Palmou-Fontana, Giulia Cassone, Ulrich Drott, Christiane Delbrück, Jorge Rojas-Serrano, Chiara Bertolazzi, Laura Nuño, Margherita Giannini, Florenzo Iannone, Esther F. Vicente, Santos Castañeda, Albert Selva-O’Callaghan, Ernesto Trallero Araguas, Giacomo Emmi, Annamaria Iuliano, Jutta Bauhammer, Nikolaus Miehle, Simone Parisi, Lorenzo Cavagna, Veronica Codullo, Carlomaurizio Montecucco, Francisco Javier Lopez-Longo, Julia Martínez-Barrio, Juan Carlos Nieto-González, Silvia Vichi, Marco Confalonieri, Paola Tomietto, Raoul Bergner, Alberto Sulli, Francesco Bonella, Federica Furini, Carlo Alberto Scirè, Alessandra Bortoluzzi, Christof Specker, Simone Barsotti, Rossella Neri, Marta Mosca, Marzia Caproni, Julia Weinmann-Menke, Andreas Schwarting, Vanessa Smith, Maurizio Cutolo
The Journal of Rheumatology Nov 2018, jrheum.180355; DOI: 10.3899/jrheum.180355
del.icio.us logo Digg logo Reddit logo Twitter logo CiteULike logo Facebook logo Google logo Mendeley logo
  • Tweet Widget
  • Facebook Like
  • Google Plus One
Save to my folders

Jump to section

  • Article
  • Figures & Data
  • Supplemental
  • References
  • Info & Metrics
  • PDF
  • eLetters

Related Articles

Cited By...

More in this TOC Section

  • Radiographic Progression Inhibition with Intravenous Golimumab in Psoriatic Arthritis: Week 24 Results of a Phase III, Randomized, Double-blind, Placebo-controlled Trial
  • OMERACT Development of a Core Domain Set of Outcomes for Shared Decision-making Interventions
  • Cyclophosphamide for Systemic Sclerosis-related Interstitial Lung Disease: A Comparison of Scleroderma Lung Study I and II
Show more Articles

Similar Articles

Content

  • First Release
  • Current
  • Archives
  • Collections
  • AV Rheum
  • Forum

Resources

  • Guide for Authors
  • Submit Manuscript
  • Author Payment
  • Reviewers
  • Advertisers
  • Classified Ads
  • Reprints and Translations
  • Permissions
  • Meetings
  • FAQ
  • Policies

Subscribers

  • Subscription Information
  • Purchase Subscription
  • Your Account
  • Terms and Conditions

More

  • About Us
  • Contact Us
  • My Alerts
  • My Folders
  • RSS Feeds
The Journal of Rheumatology
The content of this site is intended for health care professionals.
Copyright © 2016 by The Journal of Rheumatology Publishing Company Limited
Print ISSN: 0315-162X; Online ISSN: 1499-2752
Powered by HighWire