Research ArticleArticle
Preliminary Validation of the Digital Ulcer Clinical Assessment Score in Systemic Sclerosis
Cosimo Bruni, Tanaka Ngcozana, Francesca Braschi, Tiziana Pucci, Guya Piemonte, Laura Benelli, Melissa Poli, Yossra A. Suliman, Serena Guiducci, Silvia Bellando-Randone, Silvia Balduzzi, Jonathan Grotts, Christopher P. Denton, Laura Rasero, CarloMaurizio Montecucco, Daniel E. Furst and Marco Matucci-Cerinic
The Journal of Rheumatology November 2018, jrheum.171486; DOI: https://doi.org/10.3899/jrheum.171486
Cosimo Bruni
From the Department of Experimental and Clinical Medicine, and Department of Public Health, University of Florence; Department of Geriatric Medicine, Division of Rheumatology Azienda Ospedaliero- Universitaria Careggi (AOUC), Florence, Italy; the Centre for Rheumatology and Connective Tissue Diseases, University College London (UCL), Division of Medicine, London, UK; Rheumatology and Rehabilitation Department, Assiut University Hospital, Assiut, Egypt; Department of Rheumatology, Institute for Research and Health Care (IRCCS) Policlinico San Matteo Foundation, Pavia, Italy; Department of Medicine Statistics Core, and Division of Rheumatology, Department of Medicine, University of California at Los Angeles, Los Angeles, California, USA. Dr. Bruni has received a 6-month travel bursary grant from European League Against Rheumatism to undertake this project. Dr. Denton has been a consultant to Bayer, Roche, GSK, Actelion, Inventiva, CSL Behring, Takeda, Merck-Serono, MedImmune, and Biogen. He has received research grants from Actelion, GSK, Novartis, and CSL Behring. Dr. Furst has received grant/research support from AbbVie, Actelion, Amgen, BMS, the US National Institutes of Health, Novartis, Pfizer, and Roche/Genentech, and consultancy fees from AbbVie, Actelion, Amgen, BMS, Cytori, Novartis, Pfizer, and Roche/Genentech. Dr. Matucci-Cerinic has acted as a consultant to and/or received speaker fees from Actelion, GSK, BMS, Pfizer, and Italfarmaco, and he has received research grants from Actelion. C. Bruni, MD, Department of Experimental and Clinical Medicine, University of Florence, and Department of Geriatric Medicine, Division of Rheumatology AOUC; T. Ngcozana, BNurs, Centre for Rheumatology and Connective Tissue Diseases, UCL Division of Medicine; F. Braschi, BNurs, Department of Experimental and Clinical Medicine, University of Florence and Department of Geriatric Medicine, Division of Rheumatology AOUC; T. Pucci, BNurs, Department of Experimental and Clinical Medicine, University of Florence, and Department of Geriatric Medicine, Division of Rheumatology AOUC; G. Piemonte, BNurs, Department of Experimental and Clinical Medicine, University of Florence, and Department of Geriatric Medicine, Division of Rheumatology AOUC; L. Benelli, BNurs, Department of Experimental and Clinical Medicine, University of Florence, and Department of Geriatric Medicine, Division of Rheumatology AOUC; M. Poli, BNurs, Department of Experimental and Clinical Medicine, University of Florence, and Department of Geriatric Medicine, Division of Rheumatology AOUC; Y.A. Suliman, MD, PhD, Rheumatology and Rehabilitation Department, Assiut University Hospital; S. Guiducci, MD, PhD, Rheumatology and Rehabilitation Department, Assiut University Hospital; S. Bellando-Randone, MD, PhD, Rheumatology and Rehabilitation Department, Assiut University Hospital; S. Balduzzi, MD, Department of Rheumatology, IRCCS Policlinico San Matteo Foundation; J. Grotts, BStat, Department of Medicine Statistics Core, University of California at Los Angeles; C.P. Denton, MD, PhD, Centre for Rheumatology and Connective Tissue Diseases, UCL Division of Medicine; L. Rasero, BNurs, Department of Public Health, University of Florence; C. Montecucco, MD, PhD, Department of Rheumatology, IRCCS Policlinico San Matteo Foundation; D.E. Furst, MD, PhD, Department of Experimental and Clinical Medicine, University of Florence, and Department of Geriatric Medicine, Division of Rheumatology AOUC, and Division of Rheumatology, Department of Medicine, University of California at Los Angeles; M. Matucci-Cerinic, MD, PhD, Department of Experimental and Clinical Medicine, University of Florence and Department of Geriatric Medicine, Division of Rheumatology AOUC. Dr. Furst and Dr. Matucci-Cerinic made equal contributions as senior authors. Address correspondence to Dr. C. Bruni, Department of Experimental and Clinical Medicine, Division of Rheumatology, University of Florence, Viale Pieraccini 18, 50139 Florence, Italy. E-mail: cosimobruni85@gmail.com. Accepted for publication August 9, 2018.
Tanaka Ngcozana
From the Department of Experimental and Clinical Medicine, and Department of Public Health, University of Florence; Department of Geriatric Medicine, Division of Rheumatology Azienda Ospedaliero- Universitaria Careggi (AOUC), Florence, Italy; the Centre for Rheumatology and Connective Tissue Diseases, University College London (UCL), Division of Medicine, London, UK; Rheumatology and Rehabilitation Department, Assiut University Hospital, Assiut, Egypt; Department of Rheumatology, Institute for Research and Health Care (IRCCS) Policlinico San Matteo Foundation, Pavia, Italy; Department of Medicine Statistics Core, and Division of Rheumatology, Department of Medicine, University of California at Los Angeles, Los Angeles, California, USA. Dr. Bruni has received a 6-month travel bursary grant from European League Against Rheumatism to undertake this project. Dr. Denton has been a consultant to Bayer, Roche, GSK, Actelion, Inventiva, CSL Behring, Takeda, Merck-Serono, MedImmune, and Biogen. He has received research grants from Actelion, GSK, Novartis, and CSL Behring. Dr. Furst has received grant/research support from AbbVie, Actelion, Amgen, BMS, the US National Institutes of Health, Novartis, Pfizer, and Roche/Genentech, and consultancy fees from AbbVie, Actelion, Amgen, BMS, Cytori, Novartis, Pfizer, and Roche/Genentech. Dr. Matucci-Cerinic has acted as a consultant to and/or received speaker fees from Actelion, GSK, BMS, Pfizer, and Italfarmaco, and he has received research grants from Actelion. C. Bruni, MD, Department of Experimental and Clinical Medicine, University of Florence, and Department of Geriatric Medicine, Division of Rheumatology AOUC; T. Ngcozana, BNurs, Centre for Rheumatology and Connective Tissue Diseases, UCL Division of Medicine; F. Braschi, BNurs, Department of Experimental and Clinical Medicine, University of Florence and Department of Geriatric Medicine, Division of Rheumatology AOUC; T. Pucci, BNurs, Department of Experimental and Clinical Medicine, University of Florence, and Department of Geriatric Medicine, Division of Rheumatology AOUC; G. Piemonte, BNurs, Department of Experimental and Clinical Medicine, University of Florence, and Department of Geriatric Medicine, Division of Rheumatology AOUC; L. Benelli, BNurs, Department of Experimental and Clinical Medicine, University of Florence, and Department of Geriatric Medicine, Division of Rheumatology AOUC; M. Poli, BNurs, Department of Experimental and Clinical Medicine, University of Florence, and Department of Geriatric Medicine, Division of Rheumatology AOUC; Y.A. Suliman, MD, PhD, Rheumatology and Rehabilitation Department, Assiut University Hospital; S. Guiducci, MD, PhD, Rheumatology and Rehabilitation Department, Assiut University Hospital; S. Bellando-Randone, MD, PhD, Rheumatology and Rehabilitation Department, Assiut University Hospital; S. Balduzzi, MD, Department of Rheumatology, IRCCS Policlinico San Matteo Foundation; J. Grotts, BStat, Department of Medicine Statistics Core, University of California at Los Angeles; C.P. Denton, MD, PhD, Centre for Rheumatology and Connective Tissue Diseases, UCL Division of Medicine; L. Rasero, BNurs, Department of Public Health, University of Florence; C. Montecucco, MD, PhD, Department of Rheumatology, IRCCS Policlinico San Matteo Foundation; D.E. Furst, MD, PhD, Department of Experimental and Clinical Medicine, University of Florence, and Department of Geriatric Medicine, Division of Rheumatology AOUC, and Division of Rheumatology, Department of Medicine, University of California at Los Angeles; M. Matucci-Cerinic, MD, PhD, Department of Experimental and Clinical Medicine, University of Florence and Department of Geriatric Medicine, Division of Rheumatology AOUC. Dr. Furst and Dr. Matucci-Cerinic made equal contributions as senior authors. Address correspondence to Dr. C. Bruni, Department of Experimental and Clinical Medicine, Division of Rheumatology, University of Florence, Viale Pieraccini 18, 50139 Florence, Italy. E-mail: cosimobruni85@gmail.com. Accepted for publication August 9, 2018.
Francesca Braschi
From the Department of Experimental and Clinical Medicine, and Department of Public Health, University of Florence; Department of Geriatric Medicine, Division of Rheumatology Azienda Ospedaliero- Universitaria Careggi (AOUC), Florence, Italy; the Centre for Rheumatology and Connective Tissue Diseases, University College London (UCL), Division of Medicine, London, UK; Rheumatology and Rehabilitation Department, Assiut University Hospital, Assiut, Egypt; Department of Rheumatology, Institute for Research and Health Care (IRCCS) Policlinico San Matteo Foundation, Pavia, Italy; Department of Medicine Statistics Core, and Division of Rheumatology, Department of Medicine, University of California at Los Angeles, Los Angeles, California, USA. Dr. Bruni has received a 6-month travel bursary grant from European League Against Rheumatism to undertake this project. Dr. Denton has been a consultant to Bayer, Roche, GSK, Actelion, Inventiva, CSL Behring, Takeda, Merck-Serono, MedImmune, and Biogen. He has received research grants from Actelion, GSK, Novartis, and CSL Behring. Dr. Furst has received grant/research support from AbbVie, Actelion, Amgen, BMS, the US National Institutes of Health, Novartis, Pfizer, and Roche/Genentech, and consultancy fees from AbbVie, Actelion, Amgen, BMS, Cytori, Novartis, Pfizer, and Roche/Genentech. Dr. Matucci-Cerinic has acted as a consultant to and/or received speaker fees from Actelion, GSK, BMS, Pfizer, and Italfarmaco, and he has received research grants from Actelion. C. Bruni, MD, Department of Experimental and Clinical Medicine, University of Florence, and Department of Geriatric Medicine, Division of Rheumatology AOUC; T. Ngcozana, BNurs, Centre for Rheumatology and Connective Tissue Diseases, UCL Division of Medicine; F. Braschi, BNurs, Department of Experimental and Clinical Medicine, University of Florence and Department of Geriatric Medicine, Division of Rheumatology AOUC; T. Pucci, BNurs, Department of Experimental and Clinical Medicine, University of Florence, and Department of Geriatric Medicine, Division of Rheumatology AOUC; G. Piemonte, BNurs, Department of Experimental and Clinical Medicine, University of Florence, and Department of Geriatric Medicine, Division of Rheumatology AOUC; L. Benelli, BNurs, Department of Experimental and Clinical Medicine, University of Florence, and Department of Geriatric Medicine, Division of Rheumatology AOUC; M. Poli, BNurs, Department of Experimental and Clinical Medicine, University of Florence, and Department of Geriatric Medicine, Division of Rheumatology AOUC; Y.A. Suliman, MD, PhD, Rheumatology and Rehabilitation Department, Assiut University Hospital; S. Guiducci, MD, PhD, Rheumatology and Rehabilitation Department, Assiut University Hospital; S. Bellando-Randone, MD, PhD, Rheumatology and Rehabilitation Department, Assiut University Hospital; S. Balduzzi, MD, Department of Rheumatology, IRCCS Policlinico San Matteo Foundation; J. Grotts, BStat, Department of Medicine Statistics Core, University of California at Los Angeles; C.P. Denton, MD, PhD, Centre for Rheumatology and Connective Tissue Diseases, UCL Division of Medicine; L. Rasero, BNurs, Department of Public Health, University of Florence; C. Montecucco, MD, PhD, Department of Rheumatology, IRCCS Policlinico San Matteo Foundation; D.E. Furst, MD, PhD, Department of Experimental and Clinical Medicine, University of Florence, and Department of Geriatric Medicine, Division of Rheumatology AOUC, and Division of Rheumatology, Department of Medicine, University of California at Los Angeles; M. Matucci-Cerinic, MD, PhD, Department of Experimental and Clinical Medicine, University of Florence and Department of Geriatric Medicine, Division of Rheumatology AOUC. Dr. Furst and Dr. Matucci-Cerinic made equal contributions as senior authors. Address correspondence to Dr. C. Bruni, Department of Experimental and Clinical Medicine, Division of Rheumatology, University of Florence, Viale Pieraccini 18, 50139 Florence, Italy. E-mail: cosimobruni85@gmail.com. Accepted for publication August 9, 2018.
Tiziana Pucci
From the Department of Experimental and Clinical Medicine, and Department of Public Health, University of Florence; Department of Geriatric Medicine, Division of Rheumatology Azienda Ospedaliero- Universitaria Careggi (AOUC), Florence, Italy; the Centre for Rheumatology and Connective Tissue Diseases, University College London (UCL), Division of Medicine, London, UK; Rheumatology and Rehabilitation Department, Assiut University Hospital, Assiut, Egypt; Department of Rheumatology, Institute for Research and Health Care (IRCCS) Policlinico San Matteo Foundation, Pavia, Italy; Department of Medicine Statistics Core, and Division of Rheumatology, Department of Medicine, University of California at Los Angeles, Los Angeles, California, USA. Dr. Bruni has received a 6-month travel bursary grant from European League Against Rheumatism to undertake this project. Dr. Denton has been a consultant to Bayer, Roche, GSK, Actelion, Inventiva, CSL Behring, Takeda, Merck-Serono, MedImmune, and Biogen. He has received research grants from Actelion, GSK, Novartis, and CSL Behring. Dr. Furst has received grant/research support from AbbVie, Actelion, Amgen, BMS, the US National Institutes of Health, Novartis, Pfizer, and Roche/Genentech, and consultancy fees from AbbVie, Actelion, Amgen, BMS, Cytori, Novartis, Pfizer, and Roche/Genentech. Dr. Matucci-Cerinic has acted as a consultant to and/or received speaker fees from Actelion, GSK, BMS, Pfizer, and Italfarmaco, and he has received research grants from Actelion. C. Bruni, MD, Department of Experimental and Clinical Medicine, University of Florence, and Department of Geriatric Medicine, Division of Rheumatology AOUC; T. Ngcozana, BNurs, Centre for Rheumatology and Connective Tissue Diseases, UCL Division of Medicine; F. Braschi, BNurs, Department of Experimental and Clinical Medicine, University of Florence and Department of Geriatric Medicine, Division of Rheumatology AOUC; T. Pucci, BNurs, Department of Experimental and Clinical Medicine, University of Florence, and Department of Geriatric Medicine, Division of Rheumatology AOUC; G. Piemonte, BNurs, Department of Experimental and Clinical Medicine, University of Florence, and Department of Geriatric Medicine, Division of Rheumatology AOUC; L. Benelli, BNurs, Department of Experimental and Clinical Medicine, University of Florence, and Department of Geriatric Medicine, Division of Rheumatology AOUC; M. Poli, BNurs, Department of Experimental and Clinical Medicine, University of Florence, and Department of Geriatric Medicine, Division of Rheumatology AOUC; Y.A. Suliman, MD, PhD, Rheumatology and Rehabilitation Department, Assiut University Hospital; S. Guiducci, MD, PhD, Rheumatology and Rehabilitation Department, Assiut University Hospital; S. Bellando-Randone, MD, PhD, Rheumatology and Rehabilitation Department, Assiut University Hospital; S. Balduzzi, MD, Department of Rheumatology, IRCCS Policlinico San Matteo Foundation; J. Grotts, BStat, Department of Medicine Statistics Core, University of California at Los Angeles; C.P. Denton, MD, PhD, Centre for Rheumatology and Connective Tissue Diseases, UCL Division of Medicine; L. Rasero, BNurs, Department of Public Health, University of Florence; C. Montecucco, MD, PhD, Department of Rheumatology, IRCCS Policlinico San Matteo Foundation; D.E. Furst, MD, PhD, Department of Experimental and Clinical Medicine, University of Florence, and Department of Geriatric Medicine, Division of Rheumatology AOUC, and Division of Rheumatology, Department of Medicine, University of California at Los Angeles; M. Matucci-Cerinic, MD, PhD, Department of Experimental and Clinical Medicine, University of Florence and Department of Geriatric Medicine, Division of Rheumatology AOUC. Dr. Furst and Dr. Matucci-Cerinic made equal contributions as senior authors. Address correspondence to Dr. C. Bruni, Department of Experimental and Clinical Medicine, Division of Rheumatology, University of Florence, Viale Pieraccini 18, 50139 Florence, Italy. E-mail: cosimobruni85@gmail.com. Accepted for publication August 9, 2018.
Guya Piemonte
From the Department of Experimental and Clinical Medicine, and Department of Public Health, University of Florence; Department of Geriatric Medicine, Division of Rheumatology Azienda Ospedaliero- Universitaria Careggi (AOUC), Florence, Italy; the Centre for Rheumatology and Connective Tissue Diseases, University College London (UCL), Division of Medicine, London, UK; Rheumatology and Rehabilitation Department, Assiut University Hospital, Assiut, Egypt; Department of Rheumatology, Institute for Research and Health Care (IRCCS) Policlinico San Matteo Foundation, Pavia, Italy; Department of Medicine Statistics Core, and Division of Rheumatology, Department of Medicine, University of California at Los Angeles, Los Angeles, California, USA. Dr. Bruni has received a 6-month travel bursary grant from European League Against Rheumatism to undertake this project. Dr. Denton has been a consultant to Bayer, Roche, GSK, Actelion, Inventiva, CSL Behring, Takeda, Merck-Serono, MedImmune, and Biogen. He has received research grants from Actelion, GSK, Novartis, and CSL Behring. Dr. Furst has received grant/research support from AbbVie, Actelion, Amgen, BMS, the US National Institutes of Health, Novartis, Pfizer, and Roche/Genentech, and consultancy fees from AbbVie, Actelion, Amgen, BMS, Cytori, Novartis, Pfizer, and Roche/Genentech. Dr. Matucci-Cerinic has acted as a consultant to and/or received speaker fees from Actelion, GSK, BMS, Pfizer, and Italfarmaco, and he has received research grants from Actelion. C. Bruni, MD, Department of Experimental and Clinical Medicine, University of Florence, and Department of Geriatric Medicine, Division of Rheumatology AOUC; T. Ngcozana, BNurs, Centre for Rheumatology and Connective Tissue Diseases, UCL Division of Medicine; F. Braschi, BNurs, Department of Experimental and Clinical Medicine, University of Florence and Department of Geriatric Medicine, Division of Rheumatology AOUC; T. Pucci, BNurs, Department of Experimental and Clinical Medicine, University of Florence, and Department of Geriatric Medicine, Division of Rheumatology AOUC; G. Piemonte, BNurs, Department of Experimental and Clinical Medicine, University of Florence, and Department of Geriatric Medicine, Division of Rheumatology AOUC; L. Benelli, BNurs, Department of Experimental and Clinical Medicine, University of Florence, and Department of Geriatric Medicine, Division of Rheumatology AOUC; M. Poli, BNurs, Department of Experimental and Clinical Medicine, University of Florence, and Department of Geriatric Medicine, Division of Rheumatology AOUC; Y.A. Suliman, MD, PhD, Rheumatology and Rehabilitation Department, Assiut University Hospital; S. Guiducci, MD, PhD, Rheumatology and Rehabilitation Department, Assiut University Hospital; S. Bellando-Randone, MD, PhD, Rheumatology and Rehabilitation Department, Assiut University Hospital; S. Balduzzi, MD, Department of Rheumatology, IRCCS Policlinico San Matteo Foundation; J. Grotts, BStat, Department of Medicine Statistics Core, University of California at Los Angeles; C.P. Denton, MD, PhD, Centre for Rheumatology and Connective Tissue Diseases, UCL Division of Medicine; L. Rasero, BNurs, Department of Public Health, University of Florence; C. Montecucco, MD, PhD, Department of Rheumatology, IRCCS Policlinico San Matteo Foundation; D.E. Furst, MD, PhD, Department of Experimental and Clinical Medicine, University of Florence, and Department of Geriatric Medicine, Division of Rheumatology AOUC, and Division of Rheumatology, Department of Medicine, University of California at Los Angeles; M. Matucci-Cerinic, MD, PhD, Department of Experimental and Clinical Medicine, University of Florence and Department of Geriatric Medicine, Division of Rheumatology AOUC. Dr. Furst and Dr. Matucci-Cerinic made equal contributions as senior authors. Address correspondence to Dr. C. Bruni, Department of Experimental and Clinical Medicine, Division of Rheumatology, University of Florence, Viale Pieraccini 18, 50139 Florence, Italy. E-mail: cosimobruni85@gmail.com. Accepted for publication August 9, 2018.
Laura Benelli
From the Department of Experimental and Clinical Medicine, and Department of Public Health, University of Florence; Department of Geriatric Medicine, Division of Rheumatology Azienda Ospedaliero- Universitaria Careggi (AOUC), Florence, Italy; the Centre for Rheumatology and Connective Tissue Diseases, University College London (UCL), Division of Medicine, London, UK; Rheumatology and Rehabilitation Department, Assiut University Hospital, Assiut, Egypt; Department of Rheumatology, Institute for Research and Health Care (IRCCS) Policlinico San Matteo Foundation, Pavia, Italy; Department of Medicine Statistics Core, and Division of Rheumatology, Department of Medicine, University of California at Los Angeles, Los Angeles, California, USA. Dr. Bruni has received a 6-month travel bursary grant from European League Against Rheumatism to undertake this project. Dr. Denton has been a consultant to Bayer, Roche, GSK, Actelion, Inventiva, CSL Behring, Takeda, Merck-Serono, MedImmune, and Biogen. He has received research grants from Actelion, GSK, Novartis, and CSL Behring. Dr. Furst has received grant/research support from AbbVie, Actelion, Amgen, BMS, the US National Institutes of Health, Novartis, Pfizer, and Roche/Genentech, and consultancy fees from AbbVie, Actelion, Amgen, BMS, Cytori, Novartis, Pfizer, and Roche/Genentech. Dr. Matucci-Cerinic has acted as a consultant to and/or received speaker fees from Actelion, GSK, BMS, Pfizer, and Italfarmaco, and he has received research grants from Actelion. C. Bruni, MD, Department of Experimental and Clinical Medicine, University of Florence, and Department of Geriatric Medicine, Division of Rheumatology AOUC; T. Ngcozana, BNurs, Centre for Rheumatology and Connective Tissue Diseases, UCL Division of Medicine; F. Braschi, BNurs, Department of Experimental and Clinical Medicine, University of Florence and Department of Geriatric Medicine, Division of Rheumatology AOUC; T. Pucci, BNurs, Department of Experimental and Clinical Medicine, University of Florence, and Department of Geriatric Medicine, Division of Rheumatology AOUC; G. Piemonte, BNurs, Department of Experimental and Clinical Medicine, University of Florence, and Department of Geriatric Medicine, Division of Rheumatology AOUC; L. Benelli, BNurs, Department of Experimental and Clinical Medicine, University of Florence, and Department of Geriatric Medicine, Division of Rheumatology AOUC; M. Poli, BNurs, Department of Experimental and Clinical Medicine, University of Florence, and Department of Geriatric Medicine, Division of Rheumatology AOUC; Y.A. Suliman, MD, PhD, Rheumatology and Rehabilitation Department, Assiut University Hospital; S. Guiducci, MD, PhD, Rheumatology and Rehabilitation Department, Assiut University Hospital; S. Bellando-Randone, MD, PhD, Rheumatology and Rehabilitation Department, Assiut University Hospital; S. Balduzzi, MD, Department of Rheumatology, IRCCS Policlinico San Matteo Foundation; J. Grotts, BStat, Department of Medicine Statistics Core, University of California at Los Angeles; C.P. Denton, MD, PhD, Centre for Rheumatology and Connective Tissue Diseases, UCL Division of Medicine; L. Rasero, BNurs, Department of Public Health, University of Florence; C. Montecucco, MD, PhD, Department of Rheumatology, IRCCS Policlinico San Matteo Foundation; D.E. Furst, MD, PhD, Department of Experimental and Clinical Medicine, University of Florence, and Department of Geriatric Medicine, Division of Rheumatology AOUC, and Division of Rheumatology, Department of Medicine, University of California at Los Angeles; M. Matucci-Cerinic, MD, PhD, Department of Experimental and Clinical Medicine, University of Florence and Department of Geriatric Medicine, Division of Rheumatology AOUC. Dr. Furst and Dr. Matucci-Cerinic made equal contributions as senior authors. Address correspondence to Dr. C. Bruni, Department of Experimental and Clinical Medicine, Division of Rheumatology, University of Florence, Viale Pieraccini 18, 50139 Florence, Italy. E-mail: cosimobruni85@gmail.com. Accepted for publication August 9, 2018.
Melissa Poli
From the Department of Experimental and Clinical Medicine, and Department of Public Health, University of Florence; Department of Geriatric Medicine, Division of Rheumatology Azienda Ospedaliero- Universitaria Careggi (AOUC), Florence, Italy; the Centre for Rheumatology and Connective Tissue Diseases, University College London (UCL), Division of Medicine, London, UK; Rheumatology and Rehabilitation Department, Assiut University Hospital, Assiut, Egypt; Department of Rheumatology, Institute for Research and Health Care (IRCCS) Policlinico San Matteo Foundation, Pavia, Italy; Department of Medicine Statistics Core, and Division of Rheumatology, Department of Medicine, University of California at Los Angeles, Los Angeles, California, USA. Dr. Bruni has received a 6-month travel bursary grant from European League Against Rheumatism to undertake this project. Dr. Denton has been a consultant to Bayer, Roche, GSK, Actelion, Inventiva, CSL Behring, Takeda, Merck-Serono, MedImmune, and Biogen. He has received research grants from Actelion, GSK, Novartis, and CSL Behring. Dr. Furst has received grant/research support from AbbVie, Actelion, Amgen, BMS, the US National Institutes of Health, Novartis, Pfizer, and Roche/Genentech, and consultancy fees from AbbVie, Actelion, Amgen, BMS, Cytori, Novartis, Pfizer, and Roche/Genentech. Dr. Matucci-Cerinic has acted as a consultant to and/or received speaker fees from Actelion, GSK, BMS, Pfizer, and Italfarmaco, and he has received research grants from Actelion. C. Bruni, MD, Department of Experimental and Clinical Medicine, University of Florence, and Department of Geriatric Medicine, Division of Rheumatology AOUC; T. Ngcozana, BNurs, Centre for Rheumatology and Connective Tissue Diseases, UCL Division of Medicine; F. Braschi, BNurs, Department of Experimental and Clinical Medicine, University of Florence and Department of Geriatric Medicine, Division of Rheumatology AOUC; T. Pucci, BNurs, Department of Experimental and Clinical Medicine, University of Florence, and Department of Geriatric Medicine, Division of Rheumatology AOUC; G. Piemonte, BNurs, Department of Experimental and Clinical Medicine, University of Florence, and Department of Geriatric Medicine, Division of Rheumatology AOUC; L. Benelli, BNurs, Department of Experimental and Clinical Medicine, University of Florence, and Department of Geriatric Medicine, Division of Rheumatology AOUC; M. Poli, BNurs, Department of Experimental and Clinical Medicine, University of Florence, and Department of Geriatric Medicine, Division of Rheumatology AOUC; Y.A. Suliman, MD, PhD, Rheumatology and Rehabilitation Department, Assiut University Hospital; S. Guiducci, MD, PhD, Rheumatology and Rehabilitation Department, Assiut University Hospital; S. Bellando-Randone, MD, PhD, Rheumatology and Rehabilitation Department, Assiut University Hospital; S. Balduzzi, MD, Department of Rheumatology, IRCCS Policlinico San Matteo Foundation; J. Grotts, BStat, Department of Medicine Statistics Core, University of California at Los Angeles; C.P. Denton, MD, PhD, Centre for Rheumatology and Connective Tissue Diseases, UCL Division of Medicine; L. Rasero, BNurs, Department of Public Health, University of Florence; C. Montecucco, MD, PhD, Department of Rheumatology, IRCCS Policlinico San Matteo Foundation; D.E. Furst, MD, PhD, Department of Experimental and Clinical Medicine, University of Florence, and Department of Geriatric Medicine, Division of Rheumatology AOUC, and Division of Rheumatology, Department of Medicine, University of California at Los Angeles; M. Matucci-Cerinic, MD, PhD, Department of Experimental and Clinical Medicine, University of Florence and Department of Geriatric Medicine, Division of Rheumatology AOUC. Dr. Furst and Dr. Matucci-Cerinic made equal contributions as senior authors. Address correspondence to Dr. C. Bruni, Department of Experimental and Clinical Medicine, Division of Rheumatology, University of Florence, Viale Pieraccini 18, 50139 Florence, Italy. E-mail: cosimobruni85@gmail.com. Accepted for publication August 9, 2018.
Yossra A. Suliman
From the Department of Experimental and Clinical Medicine, and Department of Public Health, University of Florence; Department of Geriatric Medicine, Division of Rheumatology Azienda Ospedaliero- Universitaria Careggi (AOUC), Florence, Italy; the Centre for Rheumatology and Connective Tissue Diseases, University College London (UCL), Division of Medicine, London, UK; Rheumatology and Rehabilitation Department, Assiut University Hospital, Assiut, Egypt; Department of Rheumatology, Institute for Research and Health Care (IRCCS) Policlinico San Matteo Foundation, Pavia, Italy; Department of Medicine Statistics Core, and Division of Rheumatology, Department of Medicine, University of California at Los Angeles, Los Angeles, California, USA. Dr. Bruni has received a 6-month travel bursary grant from European League Against Rheumatism to undertake this project. Dr. Denton has been a consultant to Bayer, Roche, GSK, Actelion, Inventiva, CSL Behring, Takeda, Merck-Serono, MedImmune, and Biogen. He has received research grants from Actelion, GSK, Novartis, and CSL Behring. Dr. Furst has received grant/research support from AbbVie, Actelion, Amgen, BMS, the US National Institutes of Health, Novartis, Pfizer, and Roche/Genentech, and consultancy fees from AbbVie, Actelion, Amgen, BMS, Cytori, Novartis, Pfizer, and Roche/Genentech. Dr. Matucci-Cerinic has acted as a consultant to and/or received speaker fees from Actelion, GSK, BMS, Pfizer, and Italfarmaco, and he has received research grants from Actelion. C. Bruni, MD, Department of Experimental and Clinical Medicine, University of Florence, and Department of Geriatric Medicine, Division of Rheumatology AOUC; T. Ngcozana, BNurs, Centre for Rheumatology and Connective Tissue Diseases, UCL Division of Medicine; F. Braschi, BNurs, Department of Experimental and Clinical Medicine, University of Florence and Department of Geriatric Medicine, Division of Rheumatology AOUC; T. Pucci, BNurs, Department of Experimental and Clinical Medicine, University of Florence, and Department of Geriatric Medicine, Division of Rheumatology AOUC; G. Piemonte, BNurs, Department of Experimental and Clinical Medicine, University of Florence, and Department of Geriatric Medicine, Division of Rheumatology AOUC; L. Benelli, BNurs, Department of Experimental and Clinical Medicine, University of Florence, and Department of Geriatric Medicine, Division of Rheumatology AOUC; M. Poli, BNurs, Department of Experimental and Clinical Medicine, University of Florence, and Department of Geriatric Medicine, Division of Rheumatology AOUC; Y.A. Suliman, MD, PhD, Rheumatology and Rehabilitation Department, Assiut University Hospital; S. Guiducci, MD, PhD, Rheumatology and Rehabilitation Department, Assiut University Hospital; S. Bellando-Randone, MD, PhD, Rheumatology and Rehabilitation Department, Assiut University Hospital; S. Balduzzi, MD, Department of Rheumatology, IRCCS Policlinico San Matteo Foundation; J. Grotts, BStat, Department of Medicine Statistics Core, University of California at Los Angeles; C.P. Denton, MD, PhD, Centre for Rheumatology and Connective Tissue Diseases, UCL Division of Medicine; L. Rasero, BNurs, Department of Public Health, University of Florence; C. Montecucco, MD, PhD, Department of Rheumatology, IRCCS Policlinico San Matteo Foundation; D.E. Furst, MD, PhD, Department of Experimental and Clinical Medicine, University of Florence, and Department of Geriatric Medicine, Division of Rheumatology AOUC, and Division of Rheumatology, Department of Medicine, University of California at Los Angeles; M. Matucci-Cerinic, MD, PhD, Department of Experimental and Clinical Medicine, University of Florence and Department of Geriatric Medicine, Division of Rheumatology AOUC. Dr. Furst and Dr. Matucci-Cerinic made equal contributions as senior authors. Address correspondence to Dr. C. Bruni, Department of Experimental and Clinical Medicine, Division of Rheumatology, University of Florence, Viale Pieraccini 18, 50139 Florence, Italy. E-mail: cosimobruni85@gmail.com. Accepted for publication August 9, 2018.
Serena Guiducci
From the Department of Experimental and Clinical Medicine, and Department of Public Health, University of Florence; Department of Geriatric Medicine, Division of Rheumatology Azienda Ospedaliero- Universitaria Careggi (AOUC), Florence, Italy; the Centre for Rheumatology and Connective Tissue Diseases, University College London (UCL), Division of Medicine, London, UK; Rheumatology and Rehabilitation Department, Assiut University Hospital, Assiut, Egypt; Department of Rheumatology, Institute for Research and Health Care (IRCCS) Policlinico San Matteo Foundation, Pavia, Italy; Department of Medicine Statistics Core, and Division of Rheumatology, Department of Medicine, University of California at Los Angeles, Los Angeles, California, USA. Dr. Bruni has received a 6-month travel bursary grant from European League Against Rheumatism to undertake this project. Dr. Denton has been a consultant to Bayer, Roche, GSK, Actelion, Inventiva, CSL Behring, Takeda, Merck-Serono, MedImmune, and Biogen. He has received research grants from Actelion, GSK, Novartis, and CSL Behring. Dr. Furst has received grant/research support from AbbVie, Actelion, Amgen, BMS, the US National Institutes of Health, Novartis, Pfizer, and Roche/Genentech, and consultancy fees from AbbVie, Actelion, Amgen, BMS, Cytori, Novartis, Pfizer, and Roche/Genentech. Dr. Matucci-Cerinic has acted as a consultant to and/or received speaker fees from Actelion, GSK, BMS, Pfizer, and Italfarmaco, and he has received research grants from Actelion. C. Bruni, MD, Department of Experimental and Clinical Medicine, University of Florence, and Department of Geriatric Medicine, Division of Rheumatology AOUC; T. Ngcozana, BNurs, Centre for Rheumatology and Connective Tissue Diseases, UCL Division of Medicine; F. Braschi, BNurs, Department of Experimental and Clinical Medicine, University of Florence and Department of Geriatric Medicine, Division of Rheumatology AOUC; T. Pucci, BNurs, Department of Experimental and Clinical Medicine, University of Florence, and Department of Geriatric Medicine, Division of Rheumatology AOUC; G. Piemonte, BNurs, Department of Experimental and Clinical Medicine, University of Florence, and Department of Geriatric Medicine, Division of Rheumatology AOUC; L. Benelli, BNurs, Department of Experimental and Clinical Medicine, University of Florence, and Department of Geriatric Medicine, Division of Rheumatology AOUC; M. Poli, BNurs, Department of Experimental and Clinical Medicine, University of Florence, and Department of Geriatric Medicine, Division of Rheumatology AOUC; Y.A. Suliman, MD, PhD, Rheumatology and Rehabilitation Department, Assiut University Hospital; S. Guiducci, MD, PhD, Rheumatology and Rehabilitation Department, Assiut University Hospital; S. Bellando-Randone, MD, PhD, Rheumatology and Rehabilitation Department, Assiut University Hospital; S. Balduzzi, MD, Department of Rheumatology, IRCCS Policlinico San Matteo Foundation; J. Grotts, BStat, Department of Medicine Statistics Core, University of California at Los Angeles; C.P. Denton, MD, PhD, Centre for Rheumatology and Connective Tissue Diseases, UCL Division of Medicine; L. Rasero, BNurs, Department of Public Health, University of Florence; C. Montecucco, MD, PhD, Department of Rheumatology, IRCCS Policlinico San Matteo Foundation; D.E. Furst, MD, PhD, Department of Experimental and Clinical Medicine, University of Florence, and Department of Geriatric Medicine, Division of Rheumatology AOUC, and Division of Rheumatology, Department of Medicine, University of California at Los Angeles; M. Matucci-Cerinic, MD, PhD, Department of Experimental and Clinical Medicine, University of Florence and Department of Geriatric Medicine, Division of Rheumatology AOUC. Dr. Furst and Dr. Matucci-Cerinic made equal contributions as senior authors. Address correspondence to Dr. C. Bruni, Department of Experimental and Clinical Medicine, Division of Rheumatology, University of Florence, Viale Pieraccini 18, 50139 Florence, Italy. E-mail: cosimobruni85@gmail.com. Accepted for publication August 9, 2018.
Silvia Bellando-Randone
From the Department of Experimental and Clinical Medicine, and Department of Public Health, University of Florence; Department of Geriatric Medicine, Division of Rheumatology Azienda Ospedaliero- Universitaria Careggi (AOUC), Florence, Italy; the Centre for Rheumatology and Connective Tissue Diseases, University College London (UCL), Division of Medicine, London, UK; Rheumatology and Rehabilitation Department, Assiut University Hospital, Assiut, Egypt; Department of Rheumatology, Institute for Research and Health Care (IRCCS) Policlinico San Matteo Foundation, Pavia, Italy; Department of Medicine Statistics Core, and Division of Rheumatology, Department of Medicine, University of California at Los Angeles, Los Angeles, California, USA. Dr. Bruni has received a 6-month travel bursary grant from European League Against Rheumatism to undertake this project. Dr. Denton has been a consultant to Bayer, Roche, GSK, Actelion, Inventiva, CSL Behring, Takeda, Merck-Serono, MedImmune, and Biogen. He has received research grants from Actelion, GSK, Novartis, and CSL Behring. Dr. Furst has received grant/research support from AbbVie, Actelion, Amgen, BMS, the US National Institutes of Health, Novartis, Pfizer, and Roche/Genentech, and consultancy fees from AbbVie, Actelion, Amgen, BMS, Cytori, Novartis, Pfizer, and Roche/Genentech. Dr. Matucci-Cerinic has acted as a consultant to and/or received speaker fees from Actelion, GSK, BMS, Pfizer, and Italfarmaco, and he has received research grants from Actelion. C. Bruni, MD, Department of Experimental and Clinical Medicine, University of Florence, and Department of Geriatric Medicine, Division of Rheumatology AOUC; T. Ngcozana, BNurs, Centre for Rheumatology and Connective Tissue Diseases, UCL Division of Medicine; F. Braschi, BNurs, Department of Experimental and Clinical Medicine, University of Florence and Department of Geriatric Medicine, Division of Rheumatology AOUC; T. Pucci, BNurs, Department of Experimental and Clinical Medicine, University of Florence, and Department of Geriatric Medicine, Division of Rheumatology AOUC; G. Piemonte, BNurs, Department of Experimental and Clinical Medicine, University of Florence, and Department of Geriatric Medicine, Division of Rheumatology AOUC; L. Benelli, BNurs, Department of Experimental and Clinical Medicine, University of Florence, and Department of Geriatric Medicine, Division of Rheumatology AOUC; M. Poli, BNurs, Department of Experimental and Clinical Medicine, University of Florence, and Department of Geriatric Medicine, Division of Rheumatology AOUC; Y.A. Suliman, MD, PhD, Rheumatology and Rehabilitation Department, Assiut University Hospital; S. Guiducci, MD, PhD, Rheumatology and Rehabilitation Department, Assiut University Hospital; S. Bellando-Randone, MD, PhD, Rheumatology and Rehabilitation Department, Assiut University Hospital; S. Balduzzi, MD, Department of Rheumatology, IRCCS Policlinico San Matteo Foundation; J. Grotts, BStat, Department of Medicine Statistics Core, University of California at Los Angeles; C.P. Denton, MD, PhD, Centre for Rheumatology and Connective Tissue Diseases, UCL Division of Medicine; L. Rasero, BNurs, Department of Public Health, University of Florence; C. Montecucco, MD, PhD, Department of Rheumatology, IRCCS Policlinico San Matteo Foundation; D.E. Furst, MD, PhD, Department of Experimental and Clinical Medicine, University of Florence, and Department of Geriatric Medicine, Division of Rheumatology AOUC, and Division of Rheumatology, Department of Medicine, University of California at Los Angeles; M. Matucci-Cerinic, MD, PhD, Department of Experimental and Clinical Medicine, University of Florence and Department of Geriatric Medicine, Division of Rheumatology AOUC. Dr. Furst and Dr. Matucci-Cerinic made equal contributions as senior authors. Address correspondence to Dr. C. Bruni, Department of Experimental and Clinical Medicine, Division of Rheumatology, University of Florence, Viale Pieraccini 18, 50139 Florence, Italy. E-mail: cosimobruni85@gmail.com. Accepted for publication August 9, 2018.
Silvia Balduzzi
From the Department of Experimental and Clinical Medicine, and Department of Public Health, University of Florence; Department of Geriatric Medicine, Division of Rheumatology Azienda Ospedaliero- Universitaria Careggi (AOUC), Florence, Italy; the Centre for Rheumatology and Connective Tissue Diseases, University College London (UCL), Division of Medicine, London, UK; Rheumatology and Rehabilitation Department, Assiut University Hospital, Assiut, Egypt; Department of Rheumatology, Institute for Research and Health Care (IRCCS) Policlinico San Matteo Foundation, Pavia, Italy; Department of Medicine Statistics Core, and Division of Rheumatology, Department of Medicine, University of California at Los Angeles, Los Angeles, California, USA. Dr. Bruni has received a 6-month travel bursary grant from European League Against Rheumatism to undertake this project. Dr. Denton has been a consultant to Bayer, Roche, GSK, Actelion, Inventiva, CSL Behring, Takeda, Merck-Serono, MedImmune, and Biogen. He has received research grants from Actelion, GSK, Novartis, and CSL Behring. Dr. Furst has received grant/research support from AbbVie, Actelion, Amgen, BMS, the US National Institutes of Health, Novartis, Pfizer, and Roche/Genentech, and consultancy fees from AbbVie, Actelion, Amgen, BMS, Cytori, Novartis, Pfizer, and Roche/Genentech. Dr. Matucci-Cerinic has acted as a consultant to and/or received speaker fees from Actelion, GSK, BMS, Pfizer, and Italfarmaco, and he has received research grants from Actelion. C. Bruni, MD, Department of Experimental and Clinical Medicine, University of Florence, and Department of Geriatric Medicine, Division of Rheumatology AOUC; T. Ngcozana, BNurs, Centre for Rheumatology and Connective Tissue Diseases, UCL Division of Medicine; F. Braschi, BNurs, Department of Experimental and Clinical Medicine, University of Florence and Department of Geriatric Medicine, Division of Rheumatology AOUC; T. Pucci, BNurs, Department of Experimental and Clinical Medicine, University of Florence, and Department of Geriatric Medicine, Division of Rheumatology AOUC; G. Piemonte, BNurs, Department of Experimental and Clinical Medicine, University of Florence, and Department of Geriatric Medicine, Division of Rheumatology AOUC; L. Benelli, BNurs, Department of Experimental and Clinical Medicine, University of Florence, and Department of Geriatric Medicine, Division of Rheumatology AOUC; M. Poli, BNurs, Department of Experimental and Clinical Medicine, University of Florence, and Department of Geriatric Medicine, Division of Rheumatology AOUC; Y.A. Suliman, MD, PhD, Rheumatology and Rehabilitation Department, Assiut University Hospital; S. Guiducci, MD, PhD, Rheumatology and Rehabilitation Department, Assiut University Hospital; S. Bellando-Randone, MD, PhD, Rheumatology and Rehabilitation Department, Assiut University Hospital; S. Balduzzi, MD, Department of Rheumatology, IRCCS Policlinico San Matteo Foundation; J. Grotts, BStat, Department of Medicine Statistics Core, University of California at Los Angeles; C.P. Denton, MD, PhD, Centre for Rheumatology and Connective Tissue Diseases, UCL Division of Medicine; L. Rasero, BNurs, Department of Public Health, University of Florence; C. Montecucco, MD, PhD, Department of Rheumatology, IRCCS Policlinico San Matteo Foundation; D.E. Furst, MD, PhD, Department of Experimental and Clinical Medicine, University of Florence, and Department of Geriatric Medicine, Division of Rheumatology AOUC, and Division of Rheumatology, Department of Medicine, University of California at Los Angeles; M. Matucci-Cerinic, MD, PhD, Department of Experimental and Clinical Medicine, University of Florence and Department of Geriatric Medicine, Division of Rheumatology AOUC. Dr. Furst and Dr. Matucci-Cerinic made equal contributions as senior authors. Address correspondence to Dr. C. Bruni, Department of Experimental and Clinical Medicine, Division of Rheumatology, University of Florence, Viale Pieraccini 18, 50139 Florence, Italy. E-mail: cosimobruni85@gmail.com. Accepted for publication August 9, 2018.
Jonathan Grotts
From the Department of Experimental and Clinical Medicine, and Department of Public Health, University of Florence; Department of Geriatric Medicine, Division of Rheumatology Azienda Ospedaliero- Universitaria Careggi (AOUC), Florence, Italy; the Centre for Rheumatology and Connective Tissue Diseases, University College London (UCL), Division of Medicine, London, UK; Rheumatology and Rehabilitation Department, Assiut University Hospital, Assiut, Egypt; Department of Rheumatology, Institute for Research and Health Care (IRCCS) Policlinico San Matteo Foundation, Pavia, Italy; Department of Medicine Statistics Core, and Division of Rheumatology, Department of Medicine, University of California at Los Angeles, Los Angeles, California, USA. Dr. Bruni has received a 6-month travel bursary grant from European League Against Rheumatism to undertake this project. Dr. Denton has been a consultant to Bayer, Roche, GSK, Actelion, Inventiva, CSL Behring, Takeda, Merck-Serono, MedImmune, and Biogen. He has received research grants from Actelion, GSK, Novartis, and CSL Behring. Dr. Furst has received grant/research support from AbbVie, Actelion, Amgen, BMS, the US National Institutes of Health, Novartis, Pfizer, and Roche/Genentech, and consultancy fees from AbbVie, Actelion, Amgen, BMS, Cytori, Novartis, Pfizer, and Roche/Genentech. Dr. Matucci-Cerinic has acted as a consultant to and/or received speaker fees from Actelion, GSK, BMS, Pfizer, and Italfarmaco, and he has received research grants from Actelion. C. Bruni, MD, Department of Experimental and Clinical Medicine, University of Florence, and Department of Geriatric Medicine, Division of Rheumatology AOUC; T. Ngcozana, BNurs, Centre for Rheumatology and Connective Tissue Diseases, UCL Division of Medicine; F. Braschi, BNurs, Department of Experimental and Clinical Medicine, University of Florence and Department of Geriatric Medicine, Division of Rheumatology AOUC; T. Pucci, BNurs, Department of Experimental and Clinical Medicine, University of Florence, and Department of Geriatric Medicine, Division of Rheumatology AOUC; G. Piemonte, BNurs, Department of Experimental and Clinical Medicine, University of Florence, and Department of Geriatric Medicine, Division of Rheumatology AOUC; L. Benelli, BNurs, Department of Experimental and Clinical Medicine, University of Florence, and Department of Geriatric Medicine, Division of Rheumatology AOUC; M. Poli, BNurs, Department of Experimental and Clinical Medicine, University of Florence, and Department of Geriatric Medicine, Division of Rheumatology AOUC; Y.A. Suliman, MD, PhD, Rheumatology and Rehabilitation Department, Assiut University Hospital; S. Guiducci, MD, PhD, Rheumatology and Rehabilitation Department, Assiut University Hospital; S. Bellando-Randone, MD, PhD, Rheumatology and Rehabilitation Department, Assiut University Hospital; S. Balduzzi, MD, Department of Rheumatology, IRCCS Policlinico San Matteo Foundation; J. Grotts, BStat, Department of Medicine Statistics Core, University of California at Los Angeles; C.P. Denton, MD, PhD, Centre for Rheumatology and Connective Tissue Diseases, UCL Division of Medicine; L. Rasero, BNurs, Department of Public Health, University of Florence; C. Montecucco, MD, PhD, Department of Rheumatology, IRCCS Policlinico San Matteo Foundation; D.E. Furst, MD, PhD, Department of Experimental and Clinical Medicine, University of Florence, and Department of Geriatric Medicine, Division of Rheumatology AOUC, and Division of Rheumatology, Department of Medicine, University of California at Los Angeles; M. Matucci-Cerinic, MD, PhD, Department of Experimental and Clinical Medicine, University of Florence and Department of Geriatric Medicine, Division of Rheumatology AOUC. Dr. Furst and Dr. Matucci-Cerinic made equal contributions as senior authors. Address correspondence to Dr. C. Bruni, Department of Experimental and Clinical Medicine, Division of Rheumatology, University of Florence, Viale Pieraccini 18, 50139 Florence, Italy. E-mail: cosimobruni85@gmail.com. Accepted for publication August 9, 2018.
Christopher P. Denton
From the Department of Experimental and Clinical Medicine, and Department of Public Health, University of Florence; Department of Geriatric Medicine, Division of Rheumatology Azienda Ospedaliero- Universitaria Careggi (AOUC), Florence, Italy; the Centre for Rheumatology and Connective Tissue Diseases, University College London (UCL), Division of Medicine, London, UK; Rheumatology and Rehabilitation Department, Assiut University Hospital, Assiut, Egypt; Department of Rheumatology, Institute for Research and Health Care (IRCCS) Policlinico San Matteo Foundation, Pavia, Italy; Department of Medicine Statistics Core, and Division of Rheumatology, Department of Medicine, University of California at Los Angeles, Los Angeles, California, USA. Dr. Bruni has received a 6-month travel bursary grant from European League Against Rheumatism to undertake this project. Dr. Denton has been a consultant to Bayer, Roche, GSK, Actelion, Inventiva, CSL Behring, Takeda, Merck-Serono, MedImmune, and Biogen. He has received research grants from Actelion, GSK, Novartis, and CSL Behring. Dr. Furst has received grant/research support from AbbVie, Actelion, Amgen, BMS, the US National Institutes of Health, Novartis, Pfizer, and Roche/Genentech, and consultancy fees from AbbVie, Actelion, Amgen, BMS, Cytori, Novartis, Pfizer, and Roche/Genentech. Dr. Matucci-Cerinic has acted as a consultant to and/or received speaker fees from Actelion, GSK, BMS, Pfizer, and Italfarmaco, and he has received research grants from Actelion. C. Bruni, MD, Department of Experimental and Clinical Medicine, University of Florence, and Department of Geriatric Medicine, Division of Rheumatology AOUC; T. Ngcozana, BNurs, Centre for Rheumatology and Connective Tissue Diseases, UCL Division of Medicine; F. Braschi, BNurs, Department of Experimental and Clinical Medicine, University of Florence and Department of Geriatric Medicine, Division of Rheumatology AOUC; T. Pucci, BNurs, Department of Experimental and Clinical Medicine, University of Florence, and Department of Geriatric Medicine, Division of Rheumatology AOUC; G. Piemonte, BNurs, Department of Experimental and Clinical Medicine, University of Florence, and Department of Geriatric Medicine, Division of Rheumatology AOUC; L. Benelli, BNurs, Department of Experimental and Clinical Medicine, University of Florence, and Department of Geriatric Medicine, Division of Rheumatology AOUC; M. Poli, BNurs, Department of Experimental and Clinical Medicine, University of Florence, and Department of Geriatric Medicine, Division of Rheumatology AOUC; Y.A. Suliman, MD, PhD, Rheumatology and Rehabilitation Department, Assiut University Hospital; S. Guiducci, MD, PhD, Rheumatology and Rehabilitation Department, Assiut University Hospital; S. Bellando-Randone, MD, PhD, Rheumatology and Rehabilitation Department, Assiut University Hospital; S. Balduzzi, MD, Department of Rheumatology, IRCCS Policlinico San Matteo Foundation; J. Grotts, BStat, Department of Medicine Statistics Core, University of California at Los Angeles; C.P. Denton, MD, PhD, Centre for Rheumatology and Connective Tissue Diseases, UCL Division of Medicine; L. Rasero, BNurs, Department of Public Health, University of Florence; C. Montecucco, MD, PhD, Department of Rheumatology, IRCCS Policlinico San Matteo Foundation; D.E. Furst, MD, PhD, Department of Experimental and Clinical Medicine, University of Florence, and Department of Geriatric Medicine, Division of Rheumatology AOUC, and Division of Rheumatology, Department of Medicine, University of California at Los Angeles; M. Matucci-Cerinic, MD, PhD, Department of Experimental and Clinical Medicine, University of Florence and Department of Geriatric Medicine, Division of Rheumatology AOUC. Dr. Furst and Dr. Matucci-Cerinic made equal contributions as senior authors. Address correspondence to Dr. C. Bruni, Department of Experimental and Clinical Medicine, Division of Rheumatology, University of Florence, Viale Pieraccini 18, 50139 Florence, Italy. E-mail: cosimobruni85@gmail.com. Accepted for publication August 9, 2018.
Laura Rasero
From the Department of Experimental and Clinical Medicine, and Department of Public Health, University of Florence; Department of Geriatric Medicine, Division of Rheumatology Azienda Ospedaliero- Universitaria Careggi (AOUC), Florence, Italy; the Centre for Rheumatology and Connective Tissue Diseases, University College London (UCL), Division of Medicine, London, UK; Rheumatology and Rehabilitation Department, Assiut University Hospital, Assiut, Egypt; Department of Rheumatology, Institute for Research and Health Care (IRCCS) Policlinico San Matteo Foundation, Pavia, Italy; Department of Medicine Statistics Core, and Division of Rheumatology, Department of Medicine, University of California at Los Angeles, Los Angeles, California, USA. Dr. Bruni has received a 6-month travel bursary grant from European League Against Rheumatism to undertake this project. Dr. Denton has been a consultant to Bayer, Roche, GSK, Actelion, Inventiva, CSL Behring, Takeda, Merck-Serono, MedImmune, and Biogen. He has received research grants from Actelion, GSK, Novartis, and CSL Behring. Dr. Furst has received grant/research support from AbbVie, Actelion, Amgen, BMS, the US National Institutes of Health, Novartis, Pfizer, and Roche/Genentech, and consultancy fees from AbbVie, Actelion, Amgen, BMS, Cytori, Novartis, Pfizer, and Roche/Genentech. Dr. Matucci-Cerinic has acted as a consultant to and/or received speaker fees from Actelion, GSK, BMS, Pfizer, and Italfarmaco, and he has received research grants from Actelion. C. Bruni, MD, Department of Experimental and Clinical Medicine, University of Florence, and Department of Geriatric Medicine, Division of Rheumatology AOUC; T. Ngcozana, BNurs, Centre for Rheumatology and Connective Tissue Diseases, UCL Division of Medicine; F. Braschi, BNurs, Department of Experimental and Clinical Medicine, University of Florence and Department of Geriatric Medicine, Division of Rheumatology AOUC; T. Pucci, BNurs, Department of Experimental and Clinical Medicine, University of Florence, and Department of Geriatric Medicine, Division of Rheumatology AOUC; G. Piemonte, BNurs, Department of Experimental and Clinical Medicine, University of Florence, and Department of Geriatric Medicine, Division of Rheumatology AOUC; L. Benelli, BNurs, Department of Experimental and Clinical Medicine, University of Florence, and Department of Geriatric Medicine, Division of Rheumatology AOUC; M. Poli, BNurs, Department of Experimental and Clinical Medicine, University of Florence, and Department of Geriatric Medicine, Division of Rheumatology AOUC; Y.A. Suliman, MD, PhD, Rheumatology and Rehabilitation Department, Assiut University Hospital; S. Guiducci, MD, PhD, Rheumatology and Rehabilitation Department, Assiut University Hospital; S. Bellando-Randone, MD, PhD, Rheumatology and Rehabilitation Department, Assiut University Hospital; S. Balduzzi, MD, Department of Rheumatology, IRCCS Policlinico San Matteo Foundation; J. Grotts, BStat, Department of Medicine Statistics Core, University of California at Los Angeles; C.P. Denton, MD, PhD, Centre for Rheumatology and Connective Tissue Diseases, UCL Division of Medicine; L. Rasero, BNurs, Department of Public Health, University of Florence; C. Montecucco, MD, PhD, Department of Rheumatology, IRCCS Policlinico San Matteo Foundation; D.E. Furst, MD, PhD, Department of Experimental and Clinical Medicine, University of Florence, and Department of Geriatric Medicine, Division of Rheumatology AOUC, and Division of Rheumatology, Department of Medicine, University of California at Los Angeles; M. Matucci-Cerinic, MD, PhD, Department of Experimental and Clinical Medicine, University of Florence and Department of Geriatric Medicine, Division of Rheumatology AOUC. Dr. Furst and Dr. Matucci-Cerinic made equal contributions as senior authors. Address correspondence to Dr. C. Bruni, Department of Experimental and Clinical Medicine, Division of Rheumatology, University of Florence, Viale Pieraccini 18, 50139 Florence, Italy. E-mail: cosimobruni85@gmail.com. Accepted for publication August 9, 2018.
CarloMaurizio Montecucco
From the Department of Experimental and Clinical Medicine, and Department of Public Health, University of Florence; Department of Geriatric Medicine, Division of Rheumatology Azienda Ospedaliero- Universitaria Careggi (AOUC), Florence, Italy; the Centre for Rheumatology and Connective Tissue Diseases, University College London (UCL), Division of Medicine, London, UK; Rheumatology and Rehabilitation Department, Assiut University Hospital, Assiut, Egypt; Department of Rheumatology, Institute for Research and Health Care (IRCCS) Policlinico San Matteo Foundation, Pavia, Italy; Department of Medicine Statistics Core, and Division of Rheumatology, Department of Medicine, University of California at Los Angeles, Los Angeles, California, USA. Dr. Bruni has received a 6-month travel bursary grant from European League Against Rheumatism to undertake this project. Dr. Denton has been a consultant to Bayer, Roche, GSK, Actelion, Inventiva, CSL Behring, Takeda, Merck-Serono, MedImmune, and Biogen. He has received research grants from Actelion, GSK, Novartis, and CSL Behring. Dr. Furst has received grant/research support from AbbVie, Actelion, Amgen, BMS, the US National Institutes of Health, Novartis, Pfizer, and Roche/Genentech, and consultancy fees from AbbVie, Actelion, Amgen, BMS, Cytori, Novartis, Pfizer, and Roche/Genentech. Dr. Matucci-Cerinic has acted as a consultant to and/or received speaker fees from Actelion, GSK, BMS, Pfizer, and Italfarmaco, and he has received research grants from Actelion. C. Bruni, MD, Department of Experimental and Clinical Medicine, University of Florence, and Department of Geriatric Medicine, Division of Rheumatology AOUC; T. Ngcozana, BNurs, Centre for Rheumatology and Connective Tissue Diseases, UCL Division of Medicine; F. Braschi, BNurs, Department of Experimental and Clinical Medicine, University of Florence and Department of Geriatric Medicine, Division of Rheumatology AOUC; T. Pucci, BNurs, Department of Experimental and Clinical Medicine, University of Florence, and Department of Geriatric Medicine, Division of Rheumatology AOUC; G. Piemonte, BNurs, Department of Experimental and Clinical Medicine, University of Florence, and Department of Geriatric Medicine, Division of Rheumatology AOUC; L. Benelli, BNurs, Department of Experimental and Clinical Medicine, University of Florence, and Department of Geriatric Medicine, Division of Rheumatology AOUC; M. Poli, BNurs, Department of Experimental and Clinical Medicine, University of Florence, and Department of Geriatric Medicine, Division of Rheumatology AOUC; Y.A. Suliman, MD, PhD, Rheumatology and Rehabilitation Department, Assiut University Hospital; S. Guiducci, MD, PhD, Rheumatology and Rehabilitation Department, Assiut University Hospital; S. Bellando-Randone, MD, PhD, Rheumatology and Rehabilitation Department, Assiut University Hospital; S. Balduzzi, MD, Department of Rheumatology, IRCCS Policlinico San Matteo Foundation; J. Grotts, BStat, Department of Medicine Statistics Core, University of California at Los Angeles; C.P. Denton, MD, PhD, Centre for Rheumatology and Connective Tissue Diseases, UCL Division of Medicine; L. Rasero, BNurs, Department of Public Health, University of Florence; C. Montecucco, MD, PhD, Department of Rheumatology, IRCCS Policlinico San Matteo Foundation; D.E. Furst, MD, PhD, Department of Experimental and Clinical Medicine, University of Florence, and Department of Geriatric Medicine, Division of Rheumatology AOUC, and Division of Rheumatology, Department of Medicine, University of California at Los Angeles; M. Matucci-Cerinic, MD, PhD, Department of Experimental and Clinical Medicine, University of Florence and Department of Geriatric Medicine, Division of Rheumatology AOUC. Dr. Furst and Dr. Matucci-Cerinic made equal contributions as senior authors. Address correspondence to Dr. C. Bruni, Department of Experimental and Clinical Medicine, Division of Rheumatology, University of Florence, Viale Pieraccini 18, 50139 Florence, Italy. E-mail: cosimobruni85@gmail.com. Accepted for publication August 9, 2018.
Daniel E. Furst
From the Department of Experimental and Clinical Medicine, and Department of Public Health, University of Florence; Department of Geriatric Medicine, Division of Rheumatology Azienda Ospedaliero- Universitaria Careggi (AOUC), Florence, Italy; the Centre for Rheumatology and Connective Tissue Diseases, University College London (UCL), Division of Medicine, London, UK; Rheumatology and Rehabilitation Department, Assiut University Hospital, Assiut, Egypt; Department of Rheumatology, Institute for Research and Health Care (IRCCS) Policlinico San Matteo Foundation, Pavia, Italy; Department of Medicine Statistics Core, and Division of Rheumatology, Department of Medicine, University of California at Los Angeles, Los Angeles, California, USA. Dr. Bruni has received a 6-month travel bursary grant from European League Against Rheumatism to undertake this project. Dr. Denton has been a consultant to Bayer, Roche, GSK, Actelion, Inventiva, CSL Behring, Takeda, Merck-Serono, MedImmune, and Biogen. He has received research grants from Actelion, GSK, Novartis, and CSL Behring. Dr. Furst has received grant/research support from AbbVie, Actelion, Amgen, BMS, the US National Institutes of Health, Novartis, Pfizer, and Roche/Genentech, and consultancy fees from AbbVie, Actelion, Amgen, BMS, Cytori, Novartis, Pfizer, and Roche/Genentech. Dr. Matucci-Cerinic has acted as a consultant to and/or received speaker fees from Actelion, GSK, BMS, Pfizer, and Italfarmaco, and he has received research grants from Actelion. C. Bruni, MD, Department of Experimental and Clinical Medicine, University of Florence, and Department of Geriatric Medicine, Division of Rheumatology AOUC; T. Ngcozana, BNurs, Centre for Rheumatology and Connective Tissue Diseases, UCL Division of Medicine; F. Braschi, BNurs, Department of Experimental and Clinical Medicine, University of Florence and Department of Geriatric Medicine, Division of Rheumatology AOUC; T. Pucci, BNurs, Department of Experimental and Clinical Medicine, University of Florence, and Department of Geriatric Medicine, Division of Rheumatology AOUC; G. Piemonte, BNurs, Department of Experimental and Clinical Medicine, University of Florence, and Department of Geriatric Medicine, Division of Rheumatology AOUC; L. Benelli, BNurs, Department of Experimental and Clinical Medicine, University of Florence, and Department of Geriatric Medicine, Division of Rheumatology AOUC; M. Poli, BNurs, Department of Experimental and Clinical Medicine, University of Florence, and Department of Geriatric Medicine, Division of Rheumatology AOUC; Y.A. Suliman, MD, PhD, Rheumatology and Rehabilitation Department, Assiut University Hospital; S. Guiducci, MD, PhD, Rheumatology and Rehabilitation Department, Assiut University Hospital; S. Bellando-Randone, MD, PhD, Rheumatology and Rehabilitation Department, Assiut University Hospital; S. Balduzzi, MD, Department of Rheumatology, IRCCS Policlinico San Matteo Foundation; J. Grotts, BStat, Department of Medicine Statistics Core, University of California at Los Angeles; C.P. Denton, MD, PhD, Centre for Rheumatology and Connective Tissue Diseases, UCL Division of Medicine; L. Rasero, BNurs, Department of Public Health, University of Florence; C. Montecucco, MD, PhD, Department of Rheumatology, IRCCS Policlinico San Matteo Foundation; D.E. Furst, MD, PhD, Department of Experimental and Clinical Medicine, University of Florence, and Department of Geriatric Medicine, Division of Rheumatology AOUC, and Division of Rheumatology, Department of Medicine, University of California at Los Angeles; M. Matucci-Cerinic, MD, PhD, Department of Experimental and Clinical Medicine, University of Florence and Department of Geriatric Medicine, Division of Rheumatology AOUC. Dr. Furst and Dr. Matucci-Cerinic made equal contributions as senior authors. Address correspondence to Dr. C. Bruni, Department of Experimental and Clinical Medicine, Division of Rheumatology, University of Florence, Viale Pieraccini 18, 50139 Florence, Italy. E-mail: cosimobruni85@gmail.com. Accepted for publication August 9, 2018.
Marco Matucci-Cerinic
From the Department of Experimental and Clinical Medicine, and Department of Public Health, University of Florence; Department of Geriatric Medicine, Division of Rheumatology Azienda Ospedaliero- Universitaria Careggi (AOUC), Florence, Italy; the Centre for Rheumatology and Connective Tissue Diseases, University College London (UCL), Division of Medicine, London, UK; Rheumatology and Rehabilitation Department, Assiut University Hospital, Assiut, Egypt; Department of Rheumatology, Institute for Research and Health Care (IRCCS) Policlinico San Matteo Foundation, Pavia, Italy; Department of Medicine Statistics Core, and Division of Rheumatology, Department of Medicine, University of California at Los Angeles, Los Angeles, California, USA. Dr. Bruni has received a 6-month travel bursary grant from European League Against Rheumatism to undertake this project. Dr. Denton has been a consultant to Bayer, Roche, GSK, Actelion, Inventiva, CSL Behring, Takeda, Merck-Serono, MedImmune, and Biogen. He has received research grants from Actelion, GSK, Novartis, and CSL Behring. Dr. Furst has received grant/research support from AbbVie, Actelion, Amgen, BMS, the US National Institutes of Health, Novartis, Pfizer, and Roche/Genentech, and consultancy fees from AbbVie, Actelion, Amgen, BMS, Cytori, Novartis, Pfizer, and Roche/Genentech. Dr. Matucci-Cerinic has acted as a consultant to and/or received speaker fees from Actelion, GSK, BMS, Pfizer, and Italfarmaco, and he has received research grants from Actelion. C. Bruni, MD, Department of Experimental and Clinical Medicine, University of Florence, and Department of Geriatric Medicine, Division of Rheumatology AOUC; T. Ngcozana, BNurs, Centre for Rheumatology and Connective Tissue Diseases, UCL Division of Medicine; F. Braschi, BNurs, Department of Experimental and Clinical Medicine, University of Florence and Department of Geriatric Medicine, Division of Rheumatology AOUC; T. Pucci, BNurs, Department of Experimental and Clinical Medicine, University of Florence, and Department of Geriatric Medicine, Division of Rheumatology AOUC; G. Piemonte, BNurs, Department of Experimental and Clinical Medicine, University of Florence, and Department of Geriatric Medicine, Division of Rheumatology AOUC; L. Benelli, BNurs, Department of Experimental and Clinical Medicine, University of Florence, and Department of Geriatric Medicine, Division of Rheumatology AOUC; M. Poli, BNurs, Department of Experimental and Clinical Medicine, University of Florence, and Department of Geriatric Medicine, Division of Rheumatology AOUC; Y.A. Suliman, MD, PhD, Rheumatology and Rehabilitation Department, Assiut University Hospital; S. Guiducci, MD, PhD, Rheumatology and Rehabilitation Department, Assiut University Hospital; S. Bellando-Randone, MD, PhD, Rheumatology and Rehabilitation Department, Assiut University Hospital; S. Balduzzi, MD, Department of Rheumatology, IRCCS Policlinico San Matteo Foundation; J. Grotts, BStat, Department of Medicine Statistics Core, University of California at Los Angeles; C.P. Denton, MD, PhD, Centre for Rheumatology and Connective Tissue Diseases, UCL Division of Medicine; L. Rasero, BNurs, Department of Public Health, University of Florence; C. Montecucco, MD, PhD, Department of Rheumatology, IRCCS Policlinico San Matteo Foundation; D.E. Furst, MD, PhD, Department of Experimental and Clinical Medicine, University of Florence, and Department of Geriatric Medicine, Division of Rheumatology AOUC, and Division of Rheumatology, Department of Medicine, University of California at Los Angeles; M. Matucci-Cerinic, MD, PhD, Department of Experimental and Clinical Medicine, University of Florence and Department of Geriatric Medicine, Division of Rheumatology AOUC. Dr. Furst and Dr. Matucci-Cerinic made equal contributions as senior authors. Address correspondence to Dr. C. Bruni, Department of Experimental and Clinical Medicine, Division of Rheumatology, University of Florence, Viale Pieraccini 18, 50139 Florence, Italy. E-mail: cosimobruni85@gmail.com. Accepted for publication August 9, 2018.
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In this issue
The Journal of Rheumatology
Vol. 51, Issue 4
1 Apr 2024
Preliminary Validation of the Digital Ulcer Clinical Assessment Score in Systemic Sclerosis
Cosimo Bruni, Tanaka Ngcozana, Francesca Braschi, Tiziana Pucci, Guya Piemonte, Laura Benelli, Melissa Poli, Yossra A. Suliman, Serena Guiducci, Silvia Bellando-Randone, Silvia Balduzzi, Jonathan Grotts, Christopher P. Denton, Laura Rasero, CarloMaurizio Montecucco, Daniel E. Furst, Marco Matucci-Cerinic
The Journal of Rheumatology Nov 2018, jrheum.171486; DOI: 10.3899/jrheum.171486
Preliminary Validation of the Digital Ulcer Clinical Assessment Score in Systemic Sclerosis
Cosimo Bruni, Tanaka Ngcozana, Francesca Braschi, Tiziana Pucci, Guya Piemonte, Laura Benelli, Melissa Poli, Yossra A. Suliman, Serena Guiducci, Silvia Bellando-Randone, Silvia Balduzzi, Jonathan Grotts, Christopher P. Denton, Laura Rasero, CarloMaurizio Montecucco, Daniel E. Furst, Marco Matucci-Cerinic
The Journal of Rheumatology Nov 2018, jrheum.171486; DOI: 10.3899/jrheum.171486