Research ArticleArticle
Relationship Between Increased Fecal Calprotectin Levels and Interstitial Lung Disease in Systemic Sclerosis
Cristian Caimmi, Eugenia Bertoldo, Anna Venturini, Paola Caramaschi, Luca Frulloni, Rachele Ciccocioppo, Sabrina Brunelli, Luca Idolazzi, Davide Gatti, Maurizio Rossini and Ombretta Viapiana
The Journal of Rheumatology November 2018, jrheum.171445; DOI: https://doi.org/10.3899/jrheum.171445
Cristian Caimmi
From the Rheumatology Unit, and the Gastroenterology Unit, University of Verona, Policlinico G.B. Rossi, Verona, Italy. C. Caimmi, MD, Rheumatology Unit, University of Verona, Policlinico G.B. Rossi; E. Bertoldo, MD, Rheumatology Unit, University of Verona, Policlinico G.B. Rossi; A. Venturini, MD, Rheumatology Unit, University of Verona, Policlinico G.B. Rossi; P. Caramaschi, MD, Rheumatology Unit, University of Verona, Policlinico G.B. Rossi; L. Frulloni, MD, Gastroenterology Unit, University of Verona, Policlinico G.B. Rossi; R. Ciccocioppo, MD, Gastroenterology Unit, University of Verona, Policlinico G.B. Rossi; S. Brunelli, Gastroenterology Unit, University of Verona, Policlinico G.B. Rossi; L. Idolazzi, MD, Rheumatology Unit, University of Verona, Policlinico G.B. Rossi; D. Gatti, MD, Rheumatology Unit, University of Verona, Policlinico G.B. Rossi; M. Rossini, MD, Rheumatology Unit, University of Verona, Policlinico G.B. Rossi; O. Viapiana, MD, Rheumatology Unit, University of Verona, Policlinico G.B. Rossi. Address correspondence to Dr. C. Caimmi, Unità di Reumatologia, Policlinico G.B. Rossi, Piazzale Scuro, 37134 Verona, Italy. E-mail: cristian.caimmi@gmail.com. Accepted for publication August 15, 2018.
Eugenia Bertoldo
From the Rheumatology Unit, and the Gastroenterology Unit, University of Verona, Policlinico G.B. Rossi, Verona, Italy. C. Caimmi, MD, Rheumatology Unit, University of Verona, Policlinico G.B. Rossi; E. Bertoldo, MD, Rheumatology Unit, University of Verona, Policlinico G.B. Rossi; A. Venturini, MD, Rheumatology Unit, University of Verona, Policlinico G.B. Rossi; P. Caramaschi, MD, Rheumatology Unit, University of Verona, Policlinico G.B. Rossi; L. Frulloni, MD, Gastroenterology Unit, University of Verona, Policlinico G.B. Rossi; R. Ciccocioppo, MD, Gastroenterology Unit, University of Verona, Policlinico G.B. Rossi; S. Brunelli, Gastroenterology Unit, University of Verona, Policlinico G.B. Rossi; L. Idolazzi, MD, Rheumatology Unit, University of Verona, Policlinico G.B. Rossi; D. Gatti, MD, Rheumatology Unit, University of Verona, Policlinico G.B. Rossi; M. Rossini, MD, Rheumatology Unit, University of Verona, Policlinico G.B. Rossi; O. Viapiana, MD, Rheumatology Unit, University of Verona, Policlinico G.B. Rossi. Address correspondence to Dr. C. Caimmi, Unità di Reumatologia, Policlinico G.B. Rossi, Piazzale Scuro, 37134 Verona, Italy. E-mail: cristian.caimmi@gmail.com. Accepted for publication August 15, 2018.
Anna Venturini
From the Rheumatology Unit, and the Gastroenterology Unit, University of Verona, Policlinico G.B. Rossi, Verona, Italy. C. Caimmi, MD, Rheumatology Unit, University of Verona, Policlinico G.B. Rossi; E. Bertoldo, MD, Rheumatology Unit, University of Verona, Policlinico G.B. Rossi; A. Venturini, MD, Rheumatology Unit, University of Verona, Policlinico G.B. Rossi; P. Caramaschi, MD, Rheumatology Unit, University of Verona, Policlinico G.B. Rossi; L. Frulloni, MD, Gastroenterology Unit, University of Verona, Policlinico G.B. Rossi; R. Ciccocioppo, MD, Gastroenterology Unit, University of Verona, Policlinico G.B. Rossi; S. Brunelli, Gastroenterology Unit, University of Verona, Policlinico G.B. Rossi; L. Idolazzi, MD, Rheumatology Unit, University of Verona, Policlinico G.B. Rossi; D. Gatti, MD, Rheumatology Unit, University of Verona, Policlinico G.B. Rossi; M. Rossini, MD, Rheumatology Unit, University of Verona, Policlinico G.B. Rossi; O. Viapiana, MD, Rheumatology Unit, University of Verona, Policlinico G.B. Rossi. Address correspondence to Dr. C. Caimmi, Unità di Reumatologia, Policlinico G.B. Rossi, Piazzale Scuro, 37134 Verona, Italy. E-mail: cristian.caimmi@gmail.com. Accepted for publication August 15, 2018.
Paola Caramaschi
From the Rheumatology Unit, and the Gastroenterology Unit, University of Verona, Policlinico G.B. Rossi, Verona, Italy. C. Caimmi, MD, Rheumatology Unit, University of Verona, Policlinico G.B. Rossi; E. Bertoldo, MD, Rheumatology Unit, University of Verona, Policlinico G.B. Rossi; A. Venturini, MD, Rheumatology Unit, University of Verona, Policlinico G.B. Rossi; P. Caramaschi, MD, Rheumatology Unit, University of Verona, Policlinico G.B. Rossi; L. Frulloni, MD, Gastroenterology Unit, University of Verona, Policlinico G.B. Rossi; R. Ciccocioppo, MD, Gastroenterology Unit, University of Verona, Policlinico G.B. Rossi; S. Brunelli, Gastroenterology Unit, University of Verona, Policlinico G.B. Rossi; L. Idolazzi, MD, Rheumatology Unit, University of Verona, Policlinico G.B. Rossi; D. Gatti, MD, Rheumatology Unit, University of Verona, Policlinico G.B. Rossi; M. Rossini, MD, Rheumatology Unit, University of Verona, Policlinico G.B. Rossi; O. Viapiana, MD, Rheumatology Unit, University of Verona, Policlinico G.B. Rossi. Address correspondence to Dr. C. Caimmi, Unità di Reumatologia, Policlinico G.B. Rossi, Piazzale Scuro, 37134 Verona, Italy. E-mail: cristian.caimmi@gmail.com. Accepted for publication August 15, 2018.
Luca Frulloni
From the Rheumatology Unit, and the Gastroenterology Unit, University of Verona, Policlinico G.B. Rossi, Verona, Italy. C. Caimmi, MD, Rheumatology Unit, University of Verona, Policlinico G.B. Rossi; E. Bertoldo, MD, Rheumatology Unit, University of Verona, Policlinico G.B. Rossi; A. Venturini, MD, Rheumatology Unit, University of Verona, Policlinico G.B. Rossi; P. Caramaschi, MD, Rheumatology Unit, University of Verona, Policlinico G.B. Rossi; L. Frulloni, MD, Gastroenterology Unit, University of Verona, Policlinico G.B. Rossi; R. Ciccocioppo, MD, Gastroenterology Unit, University of Verona, Policlinico G.B. Rossi; S. Brunelli, Gastroenterology Unit, University of Verona, Policlinico G.B. Rossi; L. Idolazzi, MD, Rheumatology Unit, University of Verona, Policlinico G.B. Rossi; D. Gatti, MD, Rheumatology Unit, University of Verona, Policlinico G.B. Rossi; M. Rossini, MD, Rheumatology Unit, University of Verona, Policlinico G.B. Rossi; O. Viapiana, MD, Rheumatology Unit, University of Verona, Policlinico G.B. Rossi. Address correspondence to Dr. C. Caimmi, Unità di Reumatologia, Policlinico G.B. Rossi, Piazzale Scuro, 37134 Verona, Italy. E-mail: cristian.caimmi@gmail.com. Accepted for publication August 15, 2018.
Rachele Ciccocioppo
From the Rheumatology Unit, and the Gastroenterology Unit, University of Verona, Policlinico G.B. Rossi, Verona, Italy. C. Caimmi, MD, Rheumatology Unit, University of Verona, Policlinico G.B. Rossi; E. Bertoldo, MD, Rheumatology Unit, University of Verona, Policlinico G.B. Rossi; A. Venturini, MD, Rheumatology Unit, University of Verona, Policlinico G.B. Rossi; P. Caramaschi, MD, Rheumatology Unit, University of Verona, Policlinico G.B. Rossi; L. Frulloni, MD, Gastroenterology Unit, University of Verona, Policlinico G.B. Rossi; R. Ciccocioppo, MD, Gastroenterology Unit, University of Verona, Policlinico G.B. Rossi; S. Brunelli, Gastroenterology Unit, University of Verona, Policlinico G.B. Rossi; L. Idolazzi, MD, Rheumatology Unit, University of Verona, Policlinico G.B. Rossi; D. Gatti, MD, Rheumatology Unit, University of Verona, Policlinico G.B. Rossi; M. Rossini, MD, Rheumatology Unit, University of Verona, Policlinico G.B. Rossi; O. Viapiana, MD, Rheumatology Unit, University of Verona, Policlinico G.B. Rossi. Address correspondence to Dr. C. Caimmi, Unità di Reumatologia, Policlinico G.B. Rossi, Piazzale Scuro, 37134 Verona, Italy. E-mail: cristian.caimmi@gmail.com. Accepted for publication August 15, 2018.
Sabrina Brunelli
From the Rheumatology Unit, and the Gastroenterology Unit, University of Verona, Policlinico G.B. Rossi, Verona, Italy. C. Caimmi, MD, Rheumatology Unit, University of Verona, Policlinico G.B. Rossi; E. Bertoldo, MD, Rheumatology Unit, University of Verona, Policlinico G.B. Rossi; A. Venturini, MD, Rheumatology Unit, University of Verona, Policlinico G.B. Rossi; P. Caramaschi, MD, Rheumatology Unit, University of Verona, Policlinico G.B. Rossi; L. Frulloni, MD, Gastroenterology Unit, University of Verona, Policlinico G.B. Rossi; R. Ciccocioppo, MD, Gastroenterology Unit, University of Verona, Policlinico G.B. Rossi; S. Brunelli, Gastroenterology Unit, University of Verona, Policlinico G.B. Rossi; L. Idolazzi, MD, Rheumatology Unit, University of Verona, Policlinico G.B. Rossi; D. Gatti, MD, Rheumatology Unit, University of Verona, Policlinico G.B. Rossi; M. Rossini, MD, Rheumatology Unit, University of Verona, Policlinico G.B. Rossi; O. Viapiana, MD, Rheumatology Unit, University of Verona, Policlinico G.B. Rossi. Address correspondence to Dr. C. Caimmi, Unità di Reumatologia, Policlinico G.B. Rossi, Piazzale Scuro, 37134 Verona, Italy. E-mail: cristian.caimmi@gmail.com. Accepted for publication August 15, 2018.
Luca Idolazzi
From the Rheumatology Unit, and the Gastroenterology Unit, University of Verona, Policlinico G.B. Rossi, Verona, Italy. C. Caimmi, MD, Rheumatology Unit, University of Verona, Policlinico G.B. Rossi; E. Bertoldo, MD, Rheumatology Unit, University of Verona, Policlinico G.B. Rossi; A. Venturini, MD, Rheumatology Unit, University of Verona, Policlinico G.B. Rossi; P. Caramaschi, MD, Rheumatology Unit, University of Verona, Policlinico G.B. Rossi; L. Frulloni, MD, Gastroenterology Unit, University of Verona, Policlinico G.B. Rossi; R. Ciccocioppo, MD, Gastroenterology Unit, University of Verona, Policlinico G.B. Rossi; S. Brunelli, Gastroenterology Unit, University of Verona, Policlinico G.B. Rossi; L. Idolazzi, MD, Rheumatology Unit, University of Verona, Policlinico G.B. Rossi; D. Gatti, MD, Rheumatology Unit, University of Verona, Policlinico G.B. Rossi; M. Rossini, MD, Rheumatology Unit, University of Verona, Policlinico G.B. Rossi; O. Viapiana, MD, Rheumatology Unit, University of Verona, Policlinico G.B. Rossi. Address correspondence to Dr. C. Caimmi, Unità di Reumatologia, Policlinico G.B. Rossi, Piazzale Scuro, 37134 Verona, Italy. E-mail: cristian.caimmi@gmail.com. Accepted for publication August 15, 2018.
Davide Gatti
From the Rheumatology Unit, and the Gastroenterology Unit, University of Verona, Policlinico G.B. Rossi, Verona, Italy. C. Caimmi, MD, Rheumatology Unit, University of Verona, Policlinico G.B. Rossi; E. Bertoldo, MD, Rheumatology Unit, University of Verona, Policlinico G.B. Rossi; A. Venturini, MD, Rheumatology Unit, University of Verona, Policlinico G.B. Rossi; P. Caramaschi, MD, Rheumatology Unit, University of Verona, Policlinico G.B. Rossi; L. Frulloni, MD, Gastroenterology Unit, University of Verona, Policlinico G.B. Rossi; R. Ciccocioppo, MD, Gastroenterology Unit, University of Verona, Policlinico G.B. Rossi; S. Brunelli, Gastroenterology Unit, University of Verona, Policlinico G.B. Rossi; L. Idolazzi, MD, Rheumatology Unit, University of Verona, Policlinico G.B. Rossi; D. Gatti, MD, Rheumatology Unit, University of Verona, Policlinico G.B. Rossi; M. Rossini, MD, Rheumatology Unit, University of Verona, Policlinico G.B. Rossi; O. Viapiana, MD, Rheumatology Unit, University of Verona, Policlinico G.B. Rossi. Address correspondence to Dr. C. Caimmi, Unità di Reumatologia, Policlinico G.B. Rossi, Piazzale Scuro, 37134 Verona, Italy. E-mail: cristian.caimmi@gmail.com. Accepted for publication August 15, 2018.
Maurizio Rossini
From the Rheumatology Unit, and the Gastroenterology Unit, University of Verona, Policlinico G.B. Rossi, Verona, Italy. C. Caimmi, MD, Rheumatology Unit, University of Verona, Policlinico G.B. Rossi; E. Bertoldo, MD, Rheumatology Unit, University of Verona, Policlinico G.B. Rossi; A. Venturini, MD, Rheumatology Unit, University of Verona, Policlinico G.B. Rossi; P. Caramaschi, MD, Rheumatology Unit, University of Verona, Policlinico G.B. Rossi; L. Frulloni, MD, Gastroenterology Unit, University of Verona, Policlinico G.B. Rossi; R. Ciccocioppo, MD, Gastroenterology Unit, University of Verona, Policlinico G.B. Rossi; S. Brunelli, Gastroenterology Unit, University of Verona, Policlinico G.B. Rossi; L. Idolazzi, MD, Rheumatology Unit, University of Verona, Policlinico G.B. Rossi; D. Gatti, MD, Rheumatology Unit, University of Verona, Policlinico G.B. Rossi; M. Rossini, MD, Rheumatology Unit, University of Verona, Policlinico G.B. Rossi; O. Viapiana, MD, Rheumatology Unit, University of Verona, Policlinico G.B. Rossi. Address correspondence to Dr. C. Caimmi, Unità di Reumatologia, Policlinico G.B. Rossi, Piazzale Scuro, 37134 Verona, Italy. E-mail: cristian.caimmi@gmail.com. Accepted for publication August 15, 2018.
Ombretta Viapiana
From the Rheumatology Unit, and the Gastroenterology Unit, University of Verona, Policlinico G.B. Rossi, Verona, Italy. C. Caimmi, MD, Rheumatology Unit, University of Verona, Policlinico G.B. Rossi; E. Bertoldo, MD, Rheumatology Unit, University of Verona, Policlinico G.B. Rossi; A. Venturini, MD, Rheumatology Unit, University of Verona, Policlinico G.B. Rossi; P. Caramaschi, MD, Rheumatology Unit, University of Verona, Policlinico G.B. Rossi; L. Frulloni, MD, Gastroenterology Unit, University of Verona, Policlinico G.B. Rossi; R. Ciccocioppo, MD, Gastroenterology Unit, University of Verona, Policlinico G.B. Rossi; S. Brunelli, Gastroenterology Unit, University of Verona, Policlinico G.B. Rossi; L. Idolazzi, MD, Rheumatology Unit, University of Verona, Policlinico G.B. Rossi; D. Gatti, MD, Rheumatology Unit, University of Verona, Policlinico G.B. Rossi; M. Rossini, MD, Rheumatology Unit, University of Verona, Policlinico G.B. Rossi; O. Viapiana, MD, Rheumatology Unit, University of Verona, Policlinico G.B. Rossi. Address correspondence to Dr. C. Caimmi, Unità di Reumatologia, Policlinico G.B. Rossi, Piazzale Scuro, 37134 Verona, Italy. E-mail: cristian.caimmi@gmail.com. Accepted for publication August 15, 2018.

Abstract
Objective To evaluate the relationship between fecal calprotectin (FC) and interstitial lung disease (ILD) in systemic sclerosis (SSc).
Methods The study enrolled 129 outpatients with SSc. Data about disease characteristics, in particular lung involvement, were collected and FC was measured.
Results Patients with ILD (35, 27.1%) had higher values of FC (p < 0.001). In multivariate analysis, these variables were associated with increased risk of ILD: diffuse disease subset, higher modified Rodnan skin score, longer disease duration, higher severity scores, steroid treatment, and higher FC levels, while diverticulosis was protective.
Conclusion ILD is independently associated with increased FC levels in SSc.
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In this issue
The Journal of Rheumatology
Vol. 46, Issue 2
1 Feb 2019
Relationship Between Increased Fecal Calprotectin Levels and Interstitial Lung Disease in Systemic Sclerosis
Cristian Caimmi, Eugenia Bertoldo, Anna Venturini, Paola Caramaschi, Luca Frulloni, Rachele Ciccocioppo, Sabrina Brunelli, Luca Idolazzi, Davide Gatti, Maurizio Rossini, Ombretta Viapiana
The Journal of Rheumatology Nov 2018, jrheum.171445; DOI: 10.3899/jrheum.171445
Relationship Between Increased Fecal Calprotectin Levels and Interstitial Lung Disease in Systemic Sclerosis
Cristian Caimmi, Eugenia Bertoldo, Anna Venturini, Paola Caramaschi, Luca Frulloni, Rachele Ciccocioppo, Sabrina Brunelli, Luca Idolazzi, Davide Gatti, Maurizio Rossini, Ombretta Viapiana
The Journal of Rheumatology Nov 2018, jrheum.171445; DOI: 10.3899/jrheum.171445