Research ArticleArticle
HLA-DRB1 Amino Acid Positions and Residues Associated with Antibody-positive Rheumatoid Arthritis in Black South Africans
Nimmisha Govind, Richard J. Reynolds, Bridget Hodkinson, Claudia Ickinger, Michele Ramsay, S. Louis Bridges Jr. and Mohammed Tikly
The Journal of Rheumatology November 2018, jrheum.180107; DOI: https://doi.org/10.3899/jrheum.180107
Nimmisha Govind
From the Division of Rheumatology, and Division of Human Genetics, Faculty of Health Sciences, and the Sydney Brenner Institute for Molecular Bioscience, University of the Witwatersrand, Johannesburg, South Africa; Division of Clinical Immunology and Rheumatology, University of Alabama at Birmingham, Birmingham, Alabama, USA; University of Cape Town, Cape Town, South Africa. This work was made possible by grants from Carnegie Corporation of New York (B8749), the Connective Tissue Diseases Fund, the University of the Witwatersrand, and the Medical Research Council of South Africa to Dr. Tikly. Dr. Ramsay received financial support from the National Research Foundation of South Africa. Dr. Reynolds was supported by US National Institutes of Health grant K01 AR060848. N. Govind, PhD, Division of Rheumatology, University of the Witwatersrand; R.J. Reynolds, PhD, Division of Clinical Immunology and Rheumatology, University of Alabama at Birmingham; B. Hodkinson, PhD, University of Cape Town; C. Ickinger, MBBCh, Division of Rheumatology, University of the Witwatersrand; M. Ramsay, PhD, Sydney Brenner Institute for Molecular Bioscience, and Division of Human Genetics, Faculty of Health Sciences, University of the Witwatersrand; S.L. Bridges Jr., PhD, Division of Clinical Immunology and Rheumatology, University of Alabama at Birmingham; M. Tikly, PhD, Division of Rheumatology, University of the Witwatersrand. Address correspondence to N. Govind, Division of Rheumatology, Chris Hani Baragwanath Academic Hospital, University of the Witwatersrand, Faculty of Health Sciences, Johannesburg, South Africa. E-mail: nimmisha.govind@gmail.com. Accepted for publication July 20, 2018.
Richard J. Reynolds
From the Division of Rheumatology, and Division of Human Genetics, Faculty of Health Sciences, and the Sydney Brenner Institute for Molecular Bioscience, University of the Witwatersrand, Johannesburg, South Africa; Division of Clinical Immunology and Rheumatology, University of Alabama at Birmingham, Birmingham, Alabama, USA; University of Cape Town, Cape Town, South Africa. This work was made possible by grants from Carnegie Corporation of New York (B8749), the Connective Tissue Diseases Fund, the University of the Witwatersrand, and the Medical Research Council of South Africa to Dr. Tikly. Dr. Ramsay received financial support from the National Research Foundation of South Africa. Dr. Reynolds was supported by US National Institutes of Health grant K01 AR060848. N. Govind, PhD, Division of Rheumatology, University of the Witwatersrand; R.J. Reynolds, PhD, Division of Clinical Immunology and Rheumatology, University of Alabama at Birmingham; B. Hodkinson, PhD, University of Cape Town; C. Ickinger, MBBCh, Division of Rheumatology, University of the Witwatersrand; M. Ramsay, PhD, Sydney Brenner Institute for Molecular Bioscience, and Division of Human Genetics, Faculty of Health Sciences, University of the Witwatersrand; S.L. Bridges Jr., PhD, Division of Clinical Immunology and Rheumatology, University of Alabama at Birmingham; M. Tikly, PhD, Division of Rheumatology, University of the Witwatersrand. Address correspondence to N. Govind, Division of Rheumatology, Chris Hani Baragwanath Academic Hospital, University of the Witwatersrand, Faculty of Health Sciences, Johannesburg, South Africa. E-mail: nimmisha.govind@gmail.com. Accepted for publication July 20, 2018.
Bridget Hodkinson
From the Division of Rheumatology, and Division of Human Genetics, Faculty of Health Sciences, and the Sydney Brenner Institute for Molecular Bioscience, University of the Witwatersrand, Johannesburg, South Africa; Division of Clinical Immunology and Rheumatology, University of Alabama at Birmingham, Birmingham, Alabama, USA; University of Cape Town, Cape Town, South Africa. This work was made possible by grants from Carnegie Corporation of New York (B8749), the Connective Tissue Diseases Fund, the University of the Witwatersrand, and the Medical Research Council of South Africa to Dr. Tikly. Dr. Ramsay received financial support from the National Research Foundation of South Africa. Dr. Reynolds was supported by US National Institutes of Health grant K01 AR060848. N. Govind, PhD, Division of Rheumatology, University of the Witwatersrand; R.J. Reynolds, PhD, Division of Clinical Immunology and Rheumatology, University of Alabama at Birmingham; B. Hodkinson, PhD, University of Cape Town; C. Ickinger, MBBCh, Division of Rheumatology, University of the Witwatersrand; M. Ramsay, PhD, Sydney Brenner Institute for Molecular Bioscience, and Division of Human Genetics, Faculty of Health Sciences, University of the Witwatersrand; S.L. Bridges Jr., PhD, Division of Clinical Immunology and Rheumatology, University of Alabama at Birmingham; M. Tikly, PhD, Division of Rheumatology, University of the Witwatersrand. Address correspondence to N. Govind, Division of Rheumatology, Chris Hani Baragwanath Academic Hospital, University of the Witwatersrand, Faculty of Health Sciences, Johannesburg, South Africa. E-mail: nimmisha.govind@gmail.com. Accepted for publication July 20, 2018.
Claudia Ickinger
From the Division of Rheumatology, and Division of Human Genetics, Faculty of Health Sciences, and the Sydney Brenner Institute for Molecular Bioscience, University of the Witwatersrand, Johannesburg, South Africa; Division of Clinical Immunology and Rheumatology, University of Alabama at Birmingham, Birmingham, Alabama, USA; University of Cape Town, Cape Town, South Africa. This work was made possible by grants from Carnegie Corporation of New York (B8749), the Connective Tissue Diseases Fund, the University of the Witwatersrand, and the Medical Research Council of South Africa to Dr. Tikly. Dr. Ramsay received financial support from the National Research Foundation of South Africa. Dr. Reynolds was supported by US National Institutes of Health grant K01 AR060848. N. Govind, PhD, Division of Rheumatology, University of the Witwatersrand; R.J. Reynolds, PhD, Division of Clinical Immunology and Rheumatology, University of Alabama at Birmingham; B. Hodkinson, PhD, University of Cape Town; C. Ickinger, MBBCh, Division of Rheumatology, University of the Witwatersrand; M. Ramsay, PhD, Sydney Brenner Institute for Molecular Bioscience, and Division of Human Genetics, Faculty of Health Sciences, University of the Witwatersrand; S.L. Bridges Jr., PhD, Division of Clinical Immunology and Rheumatology, University of Alabama at Birmingham; M. Tikly, PhD, Division of Rheumatology, University of the Witwatersrand. Address correspondence to N. Govind, Division of Rheumatology, Chris Hani Baragwanath Academic Hospital, University of the Witwatersrand, Faculty of Health Sciences, Johannesburg, South Africa. E-mail: nimmisha.govind@gmail.com. Accepted for publication July 20, 2018.
Michele Ramsay
From the Division of Rheumatology, and Division of Human Genetics, Faculty of Health Sciences, and the Sydney Brenner Institute for Molecular Bioscience, University of the Witwatersrand, Johannesburg, South Africa; Division of Clinical Immunology and Rheumatology, University of Alabama at Birmingham, Birmingham, Alabama, USA; University of Cape Town, Cape Town, South Africa. This work was made possible by grants from Carnegie Corporation of New York (B8749), the Connective Tissue Diseases Fund, the University of the Witwatersrand, and the Medical Research Council of South Africa to Dr. Tikly. Dr. Ramsay received financial support from the National Research Foundation of South Africa. Dr. Reynolds was supported by US National Institutes of Health grant K01 AR060848. N. Govind, PhD, Division of Rheumatology, University of the Witwatersrand; R.J. Reynolds, PhD, Division of Clinical Immunology and Rheumatology, University of Alabama at Birmingham; B. Hodkinson, PhD, University of Cape Town; C. Ickinger, MBBCh, Division of Rheumatology, University of the Witwatersrand; M. Ramsay, PhD, Sydney Brenner Institute for Molecular Bioscience, and Division of Human Genetics, Faculty of Health Sciences, University of the Witwatersrand; S.L. Bridges Jr., PhD, Division of Clinical Immunology and Rheumatology, University of Alabama at Birmingham; M. Tikly, PhD, Division of Rheumatology, University of the Witwatersrand. Address correspondence to N. Govind, Division of Rheumatology, Chris Hani Baragwanath Academic Hospital, University of the Witwatersrand, Faculty of Health Sciences, Johannesburg, South Africa. E-mail: nimmisha.govind@gmail.com. Accepted for publication July 20, 2018.
S. Louis Bridges Jr.
From the Division of Rheumatology, and Division of Human Genetics, Faculty of Health Sciences, and the Sydney Brenner Institute for Molecular Bioscience, University of the Witwatersrand, Johannesburg, South Africa; Division of Clinical Immunology and Rheumatology, University of Alabama at Birmingham, Birmingham, Alabama, USA; University of Cape Town, Cape Town, South Africa. This work was made possible by grants from Carnegie Corporation of New York (B8749), the Connective Tissue Diseases Fund, the University of the Witwatersrand, and the Medical Research Council of South Africa to Dr. Tikly. Dr. Ramsay received financial support from the National Research Foundation of South Africa. Dr. Reynolds was supported by US National Institutes of Health grant K01 AR060848. N. Govind, PhD, Division of Rheumatology, University of the Witwatersrand; R.J. Reynolds, PhD, Division of Clinical Immunology and Rheumatology, University of Alabama at Birmingham; B. Hodkinson, PhD, University of Cape Town; C. Ickinger, MBBCh, Division of Rheumatology, University of the Witwatersrand; M. Ramsay, PhD, Sydney Brenner Institute for Molecular Bioscience, and Division of Human Genetics, Faculty of Health Sciences, University of the Witwatersrand; S.L. Bridges Jr., PhD, Division of Clinical Immunology and Rheumatology, University of Alabama at Birmingham; M. Tikly, PhD, Division of Rheumatology, University of the Witwatersrand. Address correspondence to N. Govind, Division of Rheumatology, Chris Hani Baragwanath Academic Hospital, University of the Witwatersrand, Faculty of Health Sciences, Johannesburg, South Africa. E-mail: nimmisha.govind@gmail.com. Accepted for publication July 20, 2018.
Mohammed Tikly
From the Division of Rheumatology, and Division of Human Genetics, Faculty of Health Sciences, and the Sydney Brenner Institute for Molecular Bioscience, University of the Witwatersrand, Johannesburg, South Africa; Division of Clinical Immunology and Rheumatology, University of Alabama at Birmingham, Birmingham, Alabama, USA; University of Cape Town, Cape Town, South Africa. This work was made possible by grants from Carnegie Corporation of New York (B8749), the Connective Tissue Diseases Fund, the University of the Witwatersrand, and the Medical Research Council of South Africa to Dr. Tikly. Dr. Ramsay received financial support from the National Research Foundation of South Africa. Dr. Reynolds was supported by US National Institutes of Health grant K01 AR060848. N. Govind, PhD, Division of Rheumatology, University of the Witwatersrand; R.J. Reynolds, PhD, Division of Clinical Immunology and Rheumatology, University of Alabama at Birmingham; B. Hodkinson, PhD, University of Cape Town; C. Ickinger, MBBCh, Division of Rheumatology, University of the Witwatersrand; M. Ramsay, PhD, Sydney Brenner Institute for Molecular Bioscience, and Division of Human Genetics, Faculty of Health Sciences, University of the Witwatersrand; S.L. Bridges Jr., PhD, Division of Clinical Immunology and Rheumatology, University of Alabama at Birmingham; M. Tikly, PhD, Division of Rheumatology, University of the Witwatersrand. Address correspondence to N. Govind, Division of Rheumatology, Chris Hani Baragwanath Academic Hospital, University of the Witwatersrand, Faculty of Health Sciences, Johannesburg, South Africa. E-mail: nimmisha.govind@gmail.com. Accepted for publication July 20, 2018.
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In this issue
The Journal of Rheumatology
Vol. 51, Issue 4
1 Apr 2024
HLA-DRB1 Amino Acid Positions and Residues Associated with Antibody-positive Rheumatoid Arthritis in Black South Africans
Nimmisha Govind, Richard J. Reynolds, Bridget Hodkinson, Claudia Ickinger, Michele Ramsay, S. Louis Bridges, Mohammed Tikly
The Journal of Rheumatology Nov 2018, jrheum.180107; DOI: 10.3899/jrheum.180107
HLA-DRB1 Amino Acid Positions and Residues Associated with Antibody-positive Rheumatoid Arthritis in Black South Africans
Nimmisha Govind, Richard J. Reynolds, Bridget Hodkinson, Claudia Ickinger, Michele Ramsay, S. Louis Bridges, Mohammed Tikly
The Journal of Rheumatology Nov 2018, jrheum.180107; DOI: 10.3899/jrheum.180107