Research ArticleArticle
Minimal Clinically Important Improvement of Routine Assessment of Patient Index Data 3 in Rheumatoid Arthritis
Michael M. Ward, Isabel Castrejon, Martin J. Bergman, Maria I. Alba, Lori C. Guthrie and Theodore Pincus
The Journal of Rheumatology October 2018, jrheum.180153; DOI: https://doi.org/10.3899/jrheum.180153
Michael M. Ward
From the Intramural Research Program, US National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS), National Institutes of Health (NIH), Bethesda, Maryland; Division of Rheumatology, Rush University Medical Center, Chicago, Illinois; Rheumatology, Taylor Hospital, Ridley Park, Pennsylvania, USA. This study was supported in part by the Intramural Research Program, NIAMS, NIH, and US Public Health Service grant AR45177. M.M. Ward, MD, MPH, Intramural Research Program, NIAMS, NIH; I. Castrejon, MD, PhD, Division of Rheumatology, Rush University Medical Center; M.J. Bergman, MD, Rheumatology, Taylor Hospital; M.I. Alba, MD, Intramural Research Program, NIAMS, NIH; L.C. Guthrie, BSN, Intramural Research Program, NIAMS, NIH; T. Pincus, MD, Division of Rheumatology, Rush University Medical Center. Address correspondence to Dr. M.M. Ward, Intramural Research Program, NIAMS/NIH, Building 10 CRC, Room 4-1339, 10 Center Drive, Bethesda, Maryland 20892-1468, USA. E-mail: wardm1@mail.nih.gov. Accepted for publication July 19, 2018.
Isabel Castrejon
From the Intramural Research Program, US National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS), National Institutes of Health (NIH), Bethesda, Maryland; Division of Rheumatology, Rush University Medical Center, Chicago, Illinois; Rheumatology, Taylor Hospital, Ridley Park, Pennsylvania, USA. This study was supported in part by the Intramural Research Program, NIAMS, NIH, and US Public Health Service grant AR45177. M.M. Ward, MD, MPH, Intramural Research Program, NIAMS, NIH; I. Castrejon, MD, PhD, Division of Rheumatology, Rush University Medical Center; M.J. Bergman, MD, Rheumatology, Taylor Hospital; M.I. Alba, MD, Intramural Research Program, NIAMS, NIH; L.C. Guthrie, BSN, Intramural Research Program, NIAMS, NIH; T. Pincus, MD, Division of Rheumatology, Rush University Medical Center. Address correspondence to Dr. M.M. Ward, Intramural Research Program, NIAMS/NIH, Building 10 CRC, Room 4-1339, 10 Center Drive, Bethesda, Maryland 20892-1468, USA. E-mail: wardm1@mail.nih.gov. Accepted for publication July 19, 2018.
Martin J. Bergman
From the Intramural Research Program, US National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS), National Institutes of Health (NIH), Bethesda, Maryland; Division of Rheumatology, Rush University Medical Center, Chicago, Illinois; Rheumatology, Taylor Hospital, Ridley Park, Pennsylvania, USA. This study was supported in part by the Intramural Research Program, NIAMS, NIH, and US Public Health Service grant AR45177. M.M. Ward, MD, MPH, Intramural Research Program, NIAMS, NIH; I. Castrejon, MD, PhD, Division of Rheumatology, Rush University Medical Center; M.J. Bergman, MD, Rheumatology, Taylor Hospital; M.I. Alba, MD, Intramural Research Program, NIAMS, NIH; L.C. Guthrie, BSN, Intramural Research Program, NIAMS, NIH; T. Pincus, MD, Division of Rheumatology, Rush University Medical Center. Address correspondence to Dr. M.M. Ward, Intramural Research Program, NIAMS/NIH, Building 10 CRC, Room 4-1339, 10 Center Drive, Bethesda, Maryland 20892-1468, USA. E-mail: wardm1@mail.nih.gov. Accepted for publication July 19, 2018.
Maria I. Alba
From the Intramural Research Program, US National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS), National Institutes of Health (NIH), Bethesda, Maryland; Division of Rheumatology, Rush University Medical Center, Chicago, Illinois; Rheumatology, Taylor Hospital, Ridley Park, Pennsylvania, USA. This study was supported in part by the Intramural Research Program, NIAMS, NIH, and US Public Health Service grant AR45177. M.M. Ward, MD, MPH, Intramural Research Program, NIAMS, NIH; I. Castrejon, MD, PhD, Division of Rheumatology, Rush University Medical Center; M.J. Bergman, MD, Rheumatology, Taylor Hospital; M.I. Alba, MD, Intramural Research Program, NIAMS, NIH; L.C. Guthrie, BSN, Intramural Research Program, NIAMS, NIH; T. Pincus, MD, Division of Rheumatology, Rush University Medical Center. Address correspondence to Dr. M.M. Ward, Intramural Research Program, NIAMS/NIH, Building 10 CRC, Room 4-1339, 10 Center Drive, Bethesda, Maryland 20892-1468, USA. E-mail: wardm1@mail.nih.gov. Accepted for publication July 19, 2018.
Lori C. Guthrie
From the Intramural Research Program, US National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS), National Institutes of Health (NIH), Bethesda, Maryland; Division of Rheumatology, Rush University Medical Center, Chicago, Illinois; Rheumatology, Taylor Hospital, Ridley Park, Pennsylvania, USA. This study was supported in part by the Intramural Research Program, NIAMS, NIH, and US Public Health Service grant AR45177. M.M. Ward, MD, MPH, Intramural Research Program, NIAMS, NIH; I. Castrejon, MD, PhD, Division of Rheumatology, Rush University Medical Center; M.J. Bergman, MD, Rheumatology, Taylor Hospital; M.I. Alba, MD, Intramural Research Program, NIAMS, NIH; L.C. Guthrie, BSN, Intramural Research Program, NIAMS, NIH; T. Pincus, MD, Division of Rheumatology, Rush University Medical Center. Address correspondence to Dr. M.M. Ward, Intramural Research Program, NIAMS/NIH, Building 10 CRC, Room 4-1339, 10 Center Drive, Bethesda, Maryland 20892-1468, USA. E-mail: wardm1@mail.nih.gov. Accepted for publication July 19, 2018.
Theodore Pincus
From the Intramural Research Program, US National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS), National Institutes of Health (NIH), Bethesda, Maryland; Division of Rheumatology, Rush University Medical Center, Chicago, Illinois; Rheumatology, Taylor Hospital, Ridley Park, Pennsylvania, USA. This study was supported in part by the Intramural Research Program, NIAMS, NIH, and US Public Health Service grant AR45177. M.M. Ward, MD, MPH, Intramural Research Program, NIAMS, NIH; I. Castrejon, MD, PhD, Division of Rheumatology, Rush University Medical Center; M.J. Bergman, MD, Rheumatology, Taylor Hospital; M.I. Alba, MD, Intramural Research Program, NIAMS, NIH; L.C. Guthrie, BSN, Intramural Research Program, NIAMS, NIH; T. Pincus, MD, Division of Rheumatology, Rush University Medical Center. Address correspondence to Dr. M.M. Ward, Intramural Research Program, NIAMS/NIH, Building 10 CRC, Room 4-1339, 10 Center Drive, Bethesda, Maryland 20892-1468, USA. E-mail: wardm1@mail.nih.gov. Accepted for publication July 19, 2018.
Abstract
Objective To estimate minimal clinically important improvement (MCII) of RAPID-3 (Routine Assessment of Patient Index Data 3) in rheumatoid arthritis (RA).
Methods RAPID-3 was computed before and after treatment escalation in a prospective study of adults with active RA. Patient judgment of improvement was used as the standard for a receiver-operating characteristic curve, from which MCII was estimated.
Results Mean RAPID-3 improved from 16.3 to 11.1 between visits. MCII was –3.8 based on simultaneously optimized sensitivity and specificity, –3.5 using the 0.80 specificity criterion, and –4.1 using the Youden index.
Conclusion RAPID-3 improvement of 3.8/30 units appears clinically meaningful.
In this issue
The Journal of Rheumatology
Vol. 51, Issue 4
1 Apr 2024
Minimal Clinically Important Improvement of Routine Assessment of Patient Index Data 3 in Rheumatoid Arthritis
Michael M. Ward, Isabel Castrejon, Martin J. Bergman, Maria I. Alba, Lori C. Guthrie, Theodore Pincus
The Journal of Rheumatology Oct 2018, jrheum.180153; DOI: 10.3899/jrheum.180153