Research ArticleArticle
Open Access
Growth During Tocilizumab Therapy for Polyarticular-course Juvenile Idiopathic Arthritis: 2-year Data from a Phase III Clinical Trial
Kamal N. Bharucha, Hermine I. Brunner, Inmaculada Calvo Penadés, Irina Nikishina, Nadina Rubio-Pérez, Sheila Oliveira, Katarzyna Kobusinska, Heinrike Schmeling, Flavio Sztajnbok, Frank Weller-Heinemann, Elena Zholobova, Francesco Zulian, Roger Allen, Jeffrey Chaitow, James Frane, Chris Wells, Nicolino Ruperto, Fabrizio De Benedetti and for the Paediatric Rheumatology International Trials Organisation and the Pediatric Rheumatology Collaborative Study Group
The Journal of Rheumatology July 2018, jrheum.170326; DOI: https://doi.org/10.3899/jrheum.170326
Kamal N. Bharucha
From Genentech, San Francisco; Consultant, Santa Monica, California, USA; Division of Rheumatology, Department of Pediatrics, University of Cincinnati, Cincinnati Children’s Hospital Medical Center (CCHMC), Pediatric Rheumatology Collaborative Study Group (PRCSG) Coordinating Center, Cincinnati, Ohio, USA; Paediatric Rheumatology Department, Hospital Universitario La Fe, Valencia, Spain; Pediatric Department, V.A. Nasonova Research Institute of Rheumatology; Department of Pediatric Rheumatology, Hospital of Childhood Diseases, JCA-UNIT, Sechenov Moscow Medical Academy, Moscow, Russia; Department of Pediatrics, Hospital Universitario Dr. J.E. González, Universidad Autónoma de Nuevo, Monterrey, Mexico; Universidade Federal do Rio de Janeiro, Instituto de Puericultura e Pediatria Martagao Gesteira (IPPMG); Hospital Universitario Pedro Ernesto, Nucleo de Estudos da Saúde do Adolescente, Universidade do Estado do Rio de Janeiro, Rio de Janeiro, Brazil; Wojewodzki Szpital Dzieciecy, Oddzial Pediatrii, Hematologii Onkologii i Reumatologii, Bydgoszcz, Poland; Department of Pediatrics, Alberta Children’s Hospital and University of Calgary, Calgary, Alberta, Canada; Klinikum Bremen-Mitte, Professor Hess-Kinderklinik, Pädiatrische Intensivmedizin, Bremen, Germany; Rheumatology Unit, Department of Woman and Child Health, University of Padua, Padua; Istituto Giannina Gaslini, Pediatria II, Rheumatologia, Paediatric Rheumatology International Trials Organisation (PRINTO) Coordinating Centre, Genoa; Institute for Research and Health Care (IRCCS) Ospedale Pediatrico Bambino Gesù, Rome, Italy; Royal Children’s Hospital, Pediatric Rheumatology, Melbourne, Victoria; Department of Rheumatology, Sydney Children’s Hospital Network, Randwick and Westmead, Sydney, Australia; Roche Products Ltd., Welwyn Garden City, UK. The study was funded by F. Hoffmann-La Roche Ltd. Writing and editorial services were provided by ApotheCom and funded by F. Hoffmann-La Roche Ltd. K.N. Bharucha is an employee of Genentech. H.I. Brunner reports funding from F. Hoffmann-La Roche Ltd. She is employed by CCHMC, which served as the North American PRCSG Coordinating Center. She is on the speaker’s bureau of Genentech and serves as a consultant. I. Nikishina reports other funding from F. Hoffmann-La Roche Ltd. K. Kobusinska reports other funding from F. Hoffmann-La Roche Ltd. H. Schmeling reports grants from F. Hoffmann-La Roche Ltd., Janssen, Pfizer, and UCB Biosciences GmbH. J. Frane was a consultant for Genentech and has been employed as a consultant or an employee of Roche/Genentech. C. Wells is an employee of and owns shares in Roche. F. De Benedetti reports grants from Novartis, Roche, Pfizer, and Sanofi. K.N. Bharucha, PhD, MD, Genentech; H.I. Brunner, MD, MSc, Division of Rheumatology, Department of Pediatrics, University of Cincinnati, CCHMC, PRCSG Coordinating Center; I. Calvo Penadés, MD, PhD, Paediatric Rheumatology Department, Hospital Universitario La Fe; I. Nikishina, MD, PhD, Pediatric Department, V.A. Nasonova Research Institute of Rheumatology; N. Rubio-Pérez, MD, Department of Pediatrics, Hospital Universitario Dr. J.E. González, Universidad Autónoma de Nuevo; S. Oliveira, MD, Universidade Federal do Rio de Janeiro, IPPMG; K. Kobusinska, MD, Wojewodzki Szpital Dzieciecy, Oddzial Pediatrii, Hematologii Onkologii i Reumatologii; H. Schmeling, MD, Department of Pediatrics, Alberta Children’s Hospital and University of Calgary; F. Sztajnbok, MD, Hospital Universitario Pedro Ernesto, Nucleo de Estudos da Saúde do Adolescente, Universidade do Estado do Rio de Janeiro; F. Weller-Heinemann, MD, Klinikum Bremen-Mitte, Professor Hess-Kinderklinik, Pädiatrische Intensivmedizin; E. Zholobova, MD, Department of Pediatric Rheumatology, Hospital of Childhood Diseases, JCA-UNIT, Sechenov Moscow Medical Academy; F. Zulian, MD, Rheumatology Unit, Department of Woman and Child Health, University of Padua; R. Allen, MD, Royal Children’s Hospital, Pediatric Rheumatology; J. Chaitow, MD, Department of Rheumatology, Sydney Children’s Hospital Network; J. Frane, PhD, Consultant; C. Wells, Roche Products Ltd.; N. Ruperto, MD, MPH, Istituto Giannina Gaslini, Pediatria II, Rheumatologia, PRINTO Coordinating Centre; F. De Benedetti, MD, PhD, IRCCS Ospedale Pediatrico Bambino Gesù. Address correspondence to Dr. F. De Benedetti, IRCCS Ospedale Pediatrico Bambino Gesù, Piazza S. Onofrio 4, 00165 Rome, Italy. E-mail: fabrizio.debenedetti@opbg.net. Full Release Article. For details see Reprints and Permissions at jrheum.org. Accepted for publication February 16, 2018.
Hermine I. Brunner
From Genentech, San Francisco; Consultant, Santa Monica, California, USA; Division of Rheumatology, Department of Pediatrics, University of Cincinnati, Cincinnati Children’s Hospital Medical Center (CCHMC), Pediatric Rheumatology Collaborative Study Group (PRCSG) Coordinating Center, Cincinnati, Ohio, USA; Paediatric Rheumatology Department, Hospital Universitario La Fe, Valencia, Spain; Pediatric Department, V.A. Nasonova Research Institute of Rheumatology; Department of Pediatric Rheumatology, Hospital of Childhood Diseases, JCA-UNIT, Sechenov Moscow Medical Academy, Moscow, Russia; Department of Pediatrics, Hospital Universitario Dr. J.E. González, Universidad Autónoma de Nuevo, Monterrey, Mexico; Universidade Federal do Rio de Janeiro, Instituto de Puericultura e Pediatria Martagao Gesteira (IPPMG); Hospital Universitario Pedro Ernesto, Nucleo de Estudos da Saúde do Adolescente, Universidade do Estado do Rio de Janeiro, Rio de Janeiro, Brazil; Wojewodzki Szpital Dzieciecy, Oddzial Pediatrii, Hematologii Onkologii i Reumatologii, Bydgoszcz, Poland; Department of Pediatrics, Alberta Children’s Hospital and University of Calgary, Calgary, Alberta, Canada; Klinikum Bremen-Mitte, Professor Hess-Kinderklinik, Pädiatrische Intensivmedizin, Bremen, Germany; Rheumatology Unit, Department of Woman and Child Health, University of Padua, Padua; Istituto Giannina Gaslini, Pediatria II, Rheumatologia, Paediatric Rheumatology International Trials Organisation (PRINTO) Coordinating Centre, Genoa; Institute for Research and Health Care (IRCCS) Ospedale Pediatrico Bambino Gesù, Rome, Italy; Royal Children’s Hospital, Pediatric Rheumatology, Melbourne, Victoria; Department of Rheumatology, Sydney Children’s Hospital Network, Randwick and Westmead, Sydney, Australia; Roche Products Ltd., Welwyn Garden City, UK. The study was funded by F. Hoffmann-La Roche Ltd. Writing and editorial services were provided by ApotheCom and funded by F. Hoffmann-La Roche Ltd. K.N. Bharucha is an employee of Genentech. H.I. Brunner reports funding from F. Hoffmann-La Roche Ltd. She is employed by CCHMC, which served as the North American PRCSG Coordinating Center. She is on the speaker’s bureau of Genentech and serves as a consultant. I. Nikishina reports other funding from F. Hoffmann-La Roche Ltd. K. Kobusinska reports other funding from F. Hoffmann-La Roche Ltd. H. Schmeling reports grants from F. Hoffmann-La Roche Ltd., Janssen, Pfizer, and UCB Biosciences GmbH. J. Frane was a consultant for Genentech and has been employed as a consultant or an employee of Roche/Genentech. C. Wells is an employee of and owns shares in Roche. F. De Benedetti reports grants from Novartis, Roche, Pfizer, and Sanofi. K.N. Bharucha, PhD, MD, Genentech; H.I. Brunner, MD, MSc, Division of Rheumatology, Department of Pediatrics, University of Cincinnati, CCHMC, PRCSG Coordinating Center; I. Calvo Penadés, MD, PhD, Paediatric Rheumatology Department, Hospital Universitario La Fe; I. Nikishina, MD, PhD, Pediatric Department, V.A. Nasonova Research Institute of Rheumatology; N. Rubio-Pérez, MD, Department of Pediatrics, Hospital Universitario Dr. J.E. González, Universidad Autónoma de Nuevo; S. Oliveira, MD, Universidade Federal do Rio de Janeiro, IPPMG; K. Kobusinska, MD, Wojewodzki Szpital Dzieciecy, Oddzial Pediatrii, Hematologii Onkologii i Reumatologii; H. Schmeling, MD, Department of Pediatrics, Alberta Children’s Hospital and University of Calgary; F. Sztajnbok, MD, Hospital Universitario Pedro Ernesto, Nucleo de Estudos da Saúde do Adolescente, Universidade do Estado do Rio de Janeiro; F. Weller-Heinemann, MD, Klinikum Bremen-Mitte, Professor Hess-Kinderklinik, Pädiatrische Intensivmedizin; E. Zholobova, MD, Department of Pediatric Rheumatology, Hospital of Childhood Diseases, JCA-UNIT, Sechenov Moscow Medical Academy; F. Zulian, MD, Rheumatology Unit, Department of Woman and Child Health, University of Padua; R. Allen, MD, Royal Children’s Hospital, Pediatric Rheumatology; J. Chaitow, MD, Department of Rheumatology, Sydney Children’s Hospital Network; J. Frane, PhD, Consultant; C. Wells, Roche Products Ltd.; N. Ruperto, MD, MPH, Istituto Giannina Gaslini, Pediatria II, Rheumatologia, PRINTO Coordinating Centre; F. De Benedetti, MD, PhD, IRCCS Ospedale Pediatrico Bambino Gesù. Address correspondence to Dr. F. De Benedetti, IRCCS Ospedale Pediatrico Bambino Gesù, Piazza S. Onofrio 4, 00165 Rome, Italy. E-mail: fabrizio.debenedetti@opbg.net. Full Release Article. For details see Reprints and Permissions at jrheum.org. Accepted for publication February 16, 2018.
Inmaculada Calvo Penadés
From Genentech, San Francisco; Consultant, Santa Monica, California, USA; Division of Rheumatology, Department of Pediatrics, University of Cincinnati, Cincinnati Children’s Hospital Medical Center (CCHMC), Pediatric Rheumatology Collaborative Study Group (PRCSG) Coordinating Center, Cincinnati, Ohio, USA; Paediatric Rheumatology Department, Hospital Universitario La Fe, Valencia, Spain; Pediatric Department, V.A. Nasonova Research Institute of Rheumatology; Department of Pediatric Rheumatology, Hospital of Childhood Diseases, JCA-UNIT, Sechenov Moscow Medical Academy, Moscow, Russia; Department of Pediatrics, Hospital Universitario Dr. J.E. González, Universidad Autónoma de Nuevo, Monterrey, Mexico; Universidade Federal do Rio de Janeiro, Instituto de Puericultura e Pediatria Martagao Gesteira (IPPMG); Hospital Universitario Pedro Ernesto, Nucleo de Estudos da Saúde do Adolescente, Universidade do Estado do Rio de Janeiro, Rio de Janeiro, Brazil; Wojewodzki Szpital Dzieciecy, Oddzial Pediatrii, Hematologii Onkologii i Reumatologii, Bydgoszcz, Poland; Department of Pediatrics, Alberta Children’s Hospital and University of Calgary, Calgary, Alberta, Canada; Klinikum Bremen-Mitte, Professor Hess-Kinderklinik, Pädiatrische Intensivmedizin, Bremen, Germany; Rheumatology Unit, Department of Woman and Child Health, University of Padua, Padua; Istituto Giannina Gaslini, Pediatria II, Rheumatologia, Paediatric Rheumatology International Trials Organisation (PRINTO) Coordinating Centre, Genoa; Institute for Research and Health Care (IRCCS) Ospedale Pediatrico Bambino Gesù, Rome, Italy; Royal Children’s Hospital, Pediatric Rheumatology, Melbourne, Victoria; Department of Rheumatology, Sydney Children’s Hospital Network, Randwick and Westmead, Sydney, Australia; Roche Products Ltd., Welwyn Garden City, UK. The study was funded by F. Hoffmann-La Roche Ltd. Writing and editorial services were provided by ApotheCom and funded by F. Hoffmann-La Roche Ltd. K.N. Bharucha is an employee of Genentech. H.I. Brunner reports funding from F. Hoffmann-La Roche Ltd. She is employed by CCHMC, which served as the North American PRCSG Coordinating Center. She is on the speaker’s bureau of Genentech and serves as a consultant. I. Nikishina reports other funding from F. Hoffmann-La Roche Ltd. K. Kobusinska reports other funding from F. Hoffmann-La Roche Ltd. H. Schmeling reports grants from F. Hoffmann-La Roche Ltd., Janssen, Pfizer, and UCB Biosciences GmbH. J. Frane was a consultant for Genentech and has been employed as a consultant or an employee of Roche/Genentech. C. Wells is an employee of and owns shares in Roche. F. De Benedetti reports grants from Novartis, Roche, Pfizer, and Sanofi. K.N. Bharucha, PhD, MD, Genentech; H.I. Brunner, MD, MSc, Division of Rheumatology, Department of Pediatrics, University of Cincinnati, CCHMC, PRCSG Coordinating Center; I. Calvo Penadés, MD, PhD, Paediatric Rheumatology Department, Hospital Universitario La Fe; I. Nikishina, MD, PhD, Pediatric Department, V.A. Nasonova Research Institute of Rheumatology; N. Rubio-Pérez, MD, Department of Pediatrics, Hospital Universitario Dr. J.E. González, Universidad Autónoma de Nuevo; S. Oliveira, MD, Universidade Federal do Rio de Janeiro, IPPMG; K. Kobusinska, MD, Wojewodzki Szpital Dzieciecy, Oddzial Pediatrii, Hematologii Onkologii i Reumatologii; H. Schmeling, MD, Department of Pediatrics, Alberta Children’s Hospital and University of Calgary; F. Sztajnbok, MD, Hospital Universitario Pedro Ernesto, Nucleo de Estudos da Saúde do Adolescente, Universidade do Estado do Rio de Janeiro; F. Weller-Heinemann, MD, Klinikum Bremen-Mitte, Professor Hess-Kinderklinik, Pädiatrische Intensivmedizin; E. Zholobova, MD, Department of Pediatric Rheumatology, Hospital of Childhood Diseases, JCA-UNIT, Sechenov Moscow Medical Academy; F. Zulian, MD, Rheumatology Unit, Department of Woman and Child Health, University of Padua; R. Allen, MD, Royal Children’s Hospital, Pediatric Rheumatology; J. Chaitow, MD, Department of Rheumatology, Sydney Children’s Hospital Network; J. Frane, PhD, Consultant; C. Wells, Roche Products Ltd.; N. Ruperto, MD, MPH, Istituto Giannina Gaslini, Pediatria II, Rheumatologia, PRINTO Coordinating Centre; F. De Benedetti, MD, PhD, IRCCS Ospedale Pediatrico Bambino Gesù. Address correspondence to Dr. F. De Benedetti, IRCCS Ospedale Pediatrico Bambino Gesù, Piazza S. Onofrio 4, 00165 Rome, Italy. E-mail: fabrizio.debenedetti@opbg.net. Full Release Article. For details see Reprints and Permissions at jrheum.org. Accepted for publication February 16, 2018.
Irina Nikishina
From Genentech, San Francisco; Consultant, Santa Monica, California, USA; Division of Rheumatology, Department of Pediatrics, University of Cincinnati, Cincinnati Children’s Hospital Medical Center (CCHMC), Pediatric Rheumatology Collaborative Study Group (PRCSG) Coordinating Center, Cincinnati, Ohio, USA; Paediatric Rheumatology Department, Hospital Universitario La Fe, Valencia, Spain; Pediatric Department, V.A. Nasonova Research Institute of Rheumatology; Department of Pediatric Rheumatology, Hospital of Childhood Diseases, JCA-UNIT, Sechenov Moscow Medical Academy, Moscow, Russia; Department of Pediatrics, Hospital Universitario Dr. J.E. González, Universidad Autónoma de Nuevo, Monterrey, Mexico; Universidade Federal do Rio de Janeiro, Instituto de Puericultura e Pediatria Martagao Gesteira (IPPMG); Hospital Universitario Pedro Ernesto, Nucleo de Estudos da Saúde do Adolescente, Universidade do Estado do Rio de Janeiro, Rio de Janeiro, Brazil; Wojewodzki Szpital Dzieciecy, Oddzial Pediatrii, Hematologii Onkologii i Reumatologii, Bydgoszcz, Poland; Department of Pediatrics, Alberta Children’s Hospital and University of Calgary, Calgary, Alberta, Canada; Klinikum Bremen-Mitte, Professor Hess-Kinderklinik, Pädiatrische Intensivmedizin, Bremen, Germany; Rheumatology Unit, Department of Woman and Child Health, University of Padua, Padua; Istituto Giannina Gaslini, Pediatria II, Rheumatologia, Paediatric Rheumatology International Trials Organisation (PRINTO) Coordinating Centre, Genoa; Institute for Research and Health Care (IRCCS) Ospedale Pediatrico Bambino Gesù, Rome, Italy; Royal Children’s Hospital, Pediatric Rheumatology, Melbourne, Victoria; Department of Rheumatology, Sydney Children’s Hospital Network, Randwick and Westmead, Sydney, Australia; Roche Products Ltd., Welwyn Garden City, UK. The study was funded by F. Hoffmann-La Roche Ltd. Writing and editorial services were provided by ApotheCom and funded by F. Hoffmann-La Roche Ltd. K.N. Bharucha is an employee of Genentech. H.I. Brunner reports funding from F. Hoffmann-La Roche Ltd. She is employed by CCHMC, which served as the North American PRCSG Coordinating Center. She is on the speaker’s bureau of Genentech and serves as a consultant. I. Nikishina reports other funding from F. Hoffmann-La Roche Ltd. K. Kobusinska reports other funding from F. Hoffmann-La Roche Ltd. H. Schmeling reports grants from F. Hoffmann-La Roche Ltd., Janssen, Pfizer, and UCB Biosciences GmbH. J. Frane was a consultant for Genentech and has been employed as a consultant or an employee of Roche/Genentech. C. Wells is an employee of and owns shares in Roche. F. De Benedetti reports grants from Novartis, Roche, Pfizer, and Sanofi. K.N. Bharucha, PhD, MD, Genentech; H.I. Brunner, MD, MSc, Division of Rheumatology, Department of Pediatrics, University of Cincinnati, CCHMC, PRCSG Coordinating Center; I. Calvo Penadés, MD, PhD, Paediatric Rheumatology Department, Hospital Universitario La Fe; I. Nikishina, MD, PhD, Pediatric Department, V.A. Nasonova Research Institute of Rheumatology; N. Rubio-Pérez, MD, Department of Pediatrics, Hospital Universitario Dr. J.E. González, Universidad Autónoma de Nuevo; S. Oliveira, MD, Universidade Federal do Rio de Janeiro, IPPMG; K. Kobusinska, MD, Wojewodzki Szpital Dzieciecy, Oddzial Pediatrii, Hematologii Onkologii i Reumatologii; H. Schmeling, MD, Department of Pediatrics, Alberta Children’s Hospital and University of Calgary; F. Sztajnbok, MD, Hospital Universitario Pedro Ernesto, Nucleo de Estudos da Saúde do Adolescente, Universidade do Estado do Rio de Janeiro; F. Weller-Heinemann, MD, Klinikum Bremen-Mitte, Professor Hess-Kinderklinik, Pädiatrische Intensivmedizin; E. Zholobova, MD, Department of Pediatric Rheumatology, Hospital of Childhood Diseases, JCA-UNIT, Sechenov Moscow Medical Academy; F. Zulian, MD, Rheumatology Unit, Department of Woman and Child Health, University of Padua; R. Allen, MD, Royal Children’s Hospital, Pediatric Rheumatology; J. Chaitow, MD, Department of Rheumatology, Sydney Children’s Hospital Network; J. Frane, PhD, Consultant; C. Wells, Roche Products Ltd.; N. Ruperto, MD, MPH, Istituto Giannina Gaslini, Pediatria II, Rheumatologia, PRINTO Coordinating Centre; F. De Benedetti, MD, PhD, IRCCS Ospedale Pediatrico Bambino Gesù. Address correspondence to Dr. F. De Benedetti, IRCCS Ospedale Pediatrico Bambino Gesù, Piazza S. Onofrio 4, 00165 Rome, Italy. E-mail: fabrizio.debenedetti@opbg.net. Full Release Article. For details see Reprints and Permissions at jrheum.org. Accepted for publication February 16, 2018.
Nadina Rubio-Pérez
From Genentech, San Francisco; Consultant, Santa Monica, California, USA; Division of Rheumatology, Department of Pediatrics, University of Cincinnati, Cincinnati Children’s Hospital Medical Center (CCHMC), Pediatric Rheumatology Collaborative Study Group (PRCSG) Coordinating Center, Cincinnati, Ohio, USA; Paediatric Rheumatology Department, Hospital Universitario La Fe, Valencia, Spain; Pediatric Department, V.A. Nasonova Research Institute of Rheumatology; Department of Pediatric Rheumatology, Hospital of Childhood Diseases, JCA-UNIT, Sechenov Moscow Medical Academy, Moscow, Russia; Department of Pediatrics, Hospital Universitario Dr. J.E. González, Universidad Autónoma de Nuevo, Monterrey, Mexico; Universidade Federal do Rio de Janeiro, Instituto de Puericultura e Pediatria Martagao Gesteira (IPPMG); Hospital Universitario Pedro Ernesto, Nucleo de Estudos da Saúde do Adolescente, Universidade do Estado do Rio de Janeiro, Rio de Janeiro, Brazil; Wojewodzki Szpital Dzieciecy, Oddzial Pediatrii, Hematologii Onkologii i Reumatologii, Bydgoszcz, Poland; Department of Pediatrics, Alberta Children’s Hospital and University of Calgary, Calgary, Alberta, Canada; Klinikum Bremen-Mitte, Professor Hess-Kinderklinik, Pädiatrische Intensivmedizin, Bremen, Germany; Rheumatology Unit, Department of Woman and Child Health, University of Padua, Padua; Istituto Giannina Gaslini, Pediatria II, Rheumatologia, Paediatric Rheumatology International Trials Organisation (PRINTO) Coordinating Centre, Genoa; Institute for Research and Health Care (IRCCS) Ospedale Pediatrico Bambino Gesù, Rome, Italy; Royal Children’s Hospital, Pediatric Rheumatology, Melbourne, Victoria; Department of Rheumatology, Sydney Children’s Hospital Network, Randwick and Westmead, Sydney, Australia; Roche Products Ltd., Welwyn Garden City, UK. The study was funded by F. Hoffmann-La Roche Ltd. Writing and editorial services were provided by ApotheCom and funded by F. Hoffmann-La Roche Ltd. K.N. Bharucha is an employee of Genentech. H.I. Brunner reports funding from F. Hoffmann-La Roche Ltd. She is employed by CCHMC, which served as the North American PRCSG Coordinating Center. She is on the speaker’s bureau of Genentech and serves as a consultant. I. Nikishina reports other funding from F. Hoffmann-La Roche Ltd. K. Kobusinska reports other funding from F. Hoffmann-La Roche Ltd. H. Schmeling reports grants from F. Hoffmann-La Roche Ltd., Janssen, Pfizer, and UCB Biosciences GmbH. J. Frane was a consultant for Genentech and has been employed as a consultant or an employee of Roche/Genentech. C. Wells is an employee of and owns shares in Roche. F. De Benedetti reports grants from Novartis, Roche, Pfizer, and Sanofi. K.N. Bharucha, PhD, MD, Genentech; H.I. Brunner, MD, MSc, Division of Rheumatology, Department of Pediatrics, University of Cincinnati, CCHMC, PRCSG Coordinating Center; I. Calvo Penadés, MD, PhD, Paediatric Rheumatology Department, Hospital Universitario La Fe; I. Nikishina, MD, PhD, Pediatric Department, V.A. Nasonova Research Institute of Rheumatology; N. Rubio-Pérez, MD, Department of Pediatrics, Hospital Universitario Dr. J.E. González, Universidad Autónoma de Nuevo; S. Oliveira, MD, Universidade Federal do Rio de Janeiro, IPPMG; K. Kobusinska, MD, Wojewodzki Szpital Dzieciecy, Oddzial Pediatrii, Hematologii Onkologii i Reumatologii; H. Schmeling, MD, Department of Pediatrics, Alberta Children’s Hospital and University of Calgary; F. Sztajnbok, MD, Hospital Universitario Pedro Ernesto, Nucleo de Estudos da Saúde do Adolescente, Universidade do Estado do Rio de Janeiro; F. Weller-Heinemann, MD, Klinikum Bremen-Mitte, Professor Hess-Kinderklinik, Pädiatrische Intensivmedizin; E. Zholobova, MD, Department of Pediatric Rheumatology, Hospital of Childhood Diseases, JCA-UNIT, Sechenov Moscow Medical Academy; F. Zulian, MD, Rheumatology Unit, Department of Woman and Child Health, University of Padua; R. Allen, MD, Royal Children’s Hospital, Pediatric Rheumatology; J. Chaitow, MD, Department of Rheumatology, Sydney Children’s Hospital Network; J. Frane, PhD, Consultant; C. Wells, Roche Products Ltd.; N. Ruperto, MD, MPH, Istituto Giannina Gaslini, Pediatria II, Rheumatologia, PRINTO Coordinating Centre; F. De Benedetti, MD, PhD, IRCCS Ospedale Pediatrico Bambino Gesù. Address correspondence to Dr. F. De Benedetti, IRCCS Ospedale Pediatrico Bambino Gesù, Piazza S. Onofrio 4, 00165 Rome, Italy. E-mail: fabrizio.debenedetti@opbg.net. Full Release Article. For details see Reprints and Permissions at jrheum.org. Accepted for publication February 16, 2018.
Sheila Oliveira
From Genentech, San Francisco; Consultant, Santa Monica, California, USA; Division of Rheumatology, Department of Pediatrics, University of Cincinnati, Cincinnati Children’s Hospital Medical Center (CCHMC), Pediatric Rheumatology Collaborative Study Group (PRCSG) Coordinating Center, Cincinnati, Ohio, USA; Paediatric Rheumatology Department, Hospital Universitario La Fe, Valencia, Spain; Pediatric Department, V.A. Nasonova Research Institute of Rheumatology; Department of Pediatric Rheumatology, Hospital of Childhood Diseases, JCA-UNIT, Sechenov Moscow Medical Academy, Moscow, Russia; Department of Pediatrics, Hospital Universitario Dr. J.E. González, Universidad Autónoma de Nuevo, Monterrey, Mexico; Universidade Federal do Rio de Janeiro, Instituto de Puericultura e Pediatria Martagao Gesteira (IPPMG); Hospital Universitario Pedro Ernesto, Nucleo de Estudos da Saúde do Adolescente, Universidade do Estado do Rio de Janeiro, Rio de Janeiro, Brazil; Wojewodzki Szpital Dzieciecy, Oddzial Pediatrii, Hematologii Onkologii i Reumatologii, Bydgoszcz, Poland; Department of Pediatrics, Alberta Children’s Hospital and University of Calgary, Calgary, Alberta, Canada; Klinikum Bremen-Mitte, Professor Hess-Kinderklinik, Pädiatrische Intensivmedizin, Bremen, Germany; Rheumatology Unit, Department of Woman and Child Health, University of Padua, Padua; Istituto Giannina Gaslini, Pediatria II, Rheumatologia, Paediatric Rheumatology International Trials Organisation (PRINTO) Coordinating Centre, Genoa; Institute for Research and Health Care (IRCCS) Ospedale Pediatrico Bambino Gesù, Rome, Italy; Royal Children’s Hospital, Pediatric Rheumatology, Melbourne, Victoria; Department of Rheumatology, Sydney Children’s Hospital Network, Randwick and Westmead, Sydney, Australia; Roche Products Ltd., Welwyn Garden City, UK. The study was funded by F. Hoffmann-La Roche Ltd. Writing and editorial services were provided by ApotheCom and funded by F. Hoffmann-La Roche Ltd. K.N. Bharucha is an employee of Genentech. H.I. Brunner reports funding from F. Hoffmann-La Roche Ltd. She is employed by CCHMC, which served as the North American PRCSG Coordinating Center. She is on the speaker’s bureau of Genentech and serves as a consultant. I. Nikishina reports other funding from F. Hoffmann-La Roche Ltd. K. Kobusinska reports other funding from F. Hoffmann-La Roche Ltd. H. Schmeling reports grants from F. Hoffmann-La Roche Ltd., Janssen, Pfizer, and UCB Biosciences GmbH. J. Frane was a consultant for Genentech and has been employed as a consultant or an employee of Roche/Genentech. C. Wells is an employee of and owns shares in Roche. F. De Benedetti reports grants from Novartis, Roche, Pfizer, and Sanofi. K.N. Bharucha, PhD, MD, Genentech; H.I. Brunner, MD, MSc, Division of Rheumatology, Department of Pediatrics, University of Cincinnati, CCHMC, PRCSG Coordinating Center; I. Calvo Penadés, MD, PhD, Paediatric Rheumatology Department, Hospital Universitario La Fe; I. Nikishina, MD, PhD, Pediatric Department, V.A. Nasonova Research Institute of Rheumatology; N. Rubio-Pérez, MD, Department of Pediatrics, Hospital Universitario Dr. J.E. González, Universidad Autónoma de Nuevo; S. Oliveira, MD, Universidade Federal do Rio de Janeiro, IPPMG; K. Kobusinska, MD, Wojewodzki Szpital Dzieciecy, Oddzial Pediatrii, Hematologii Onkologii i Reumatologii; H. Schmeling, MD, Department of Pediatrics, Alberta Children’s Hospital and University of Calgary; F. Sztajnbok, MD, Hospital Universitario Pedro Ernesto, Nucleo de Estudos da Saúde do Adolescente, Universidade do Estado do Rio de Janeiro; F. Weller-Heinemann, MD, Klinikum Bremen-Mitte, Professor Hess-Kinderklinik, Pädiatrische Intensivmedizin; E. Zholobova, MD, Department of Pediatric Rheumatology, Hospital of Childhood Diseases, JCA-UNIT, Sechenov Moscow Medical Academy; F. Zulian, MD, Rheumatology Unit, Department of Woman and Child Health, University of Padua; R. Allen, MD, Royal Children’s Hospital, Pediatric Rheumatology; J. Chaitow, MD, Department of Rheumatology, Sydney Children’s Hospital Network; J. Frane, PhD, Consultant; C. Wells, Roche Products Ltd.; N. Ruperto, MD, MPH, Istituto Giannina Gaslini, Pediatria II, Rheumatologia, PRINTO Coordinating Centre; F. De Benedetti, MD, PhD, IRCCS Ospedale Pediatrico Bambino Gesù. Address correspondence to Dr. F. De Benedetti, IRCCS Ospedale Pediatrico Bambino Gesù, Piazza S. Onofrio 4, 00165 Rome, Italy. E-mail: fabrizio.debenedetti@opbg.net. Full Release Article. For details see Reprints and Permissions at jrheum.org. Accepted for publication February 16, 2018.
Katarzyna Kobusinska
From Genentech, San Francisco; Consultant, Santa Monica, California, USA; Division of Rheumatology, Department of Pediatrics, University of Cincinnati, Cincinnati Children’s Hospital Medical Center (CCHMC), Pediatric Rheumatology Collaborative Study Group (PRCSG) Coordinating Center, Cincinnati, Ohio, USA; Paediatric Rheumatology Department, Hospital Universitario La Fe, Valencia, Spain; Pediatric Department, V.A. Nasonova Research Institute of Rheumatology; Department of Pediatric Rheumatology, Hospital of Childhood Diseases, JCA-UNIT, Sechenov Moscow Medical Academy, Moscow, Russia; Department of Pediatrics, Hospital Universitario Dr. J.E. González, Universidad Autónoma de Nuevo, Monterrey, Mexico; Universidade Federal do Rio de Janeiro, Instituto de Puericultura e Pediatria Martagao Gesteira (IPPMG); Hospital Universitario Pedro Ernesto, Nucleo de Estudos da Saúde do Adolescente, Universidade do Estado do Rio de Janeiro, Rio de Janeiro, Brazil; Wojewodzki Szpital Dzieciecy, Oddzial Pediatrii, Hematologii Onkologii i Reumatologii, Bydgoszcz, Poland; Department of Pediatrics, Alberta Children’s Hospital and University of Calgary, Calgary, Alberta, Canada; Klinikum Bremen-Mitte, Professor Hess-Kinderklinik, Pädiatrische Intensivmedizin, Bremen, Germany; Rheumatology Unit, Department of Woman and Child Health, University of Padua, Padua; Istituto Giannina Gaslini, Pediatria II, Rheumatologia, Paediatric Rheumatology International Trials Organisation (PRINTO) Coordinating Centre, Genoa; Institute for Research and Health Care (IRCCS) Ospedale Pediatrico Bambino Gesù, Rome, Italy; Royal Children’s Hospital, Pediatric Rheumatology, Melbourne, Victoria; Department of Rheumatology, Sydney Children’s Hospital Network, Randwick and Westmead, Sydney, Australia; Roche Products Ltd., Welwyn Garden City, UK. The study was funded by F. Hoffmann-La Roche Ltd. Writing and editorial services were provided by ApotheCom and funded by F. Hoffmann-La Roche Ltd. K.N. Bharucha is an employee of Genentech. H.I. Brunner reports funding from F. Hoffmann-La Roche Ltd. She is employed by CCHMC, which served as the North American PRCSG Coordinating Center. She is on the speaker’s bureau of Genentech and serves as a consultant. I. Nikishina reports other funding from F. Hoffmann-La Roche Ltd. K. Kobusinska reports other funding from F. Hoffmann-La Roche Ltd. H. Schmeling reports grants from F. Hoffmann-La Roche Ltd., Janssen, Pfizer, and UCB Biosciences GmbH. J. Frane was a consultant for Genentech and has been employed as a consultant or an employee of Roche/Genentech. C. Wells is an employee of and owns shares in Roche. F. De Benedetti reports grants from Novartis, Roche, Pfizer, and Sanofi. K.N. Bharucha, PhD, MD, Genentech; H.I. Brunner, MD, MSc, Division of Rheumatology, Department of Pediatrics, University of Cincinnati, CCHMC, PRCSG Coordinating Center; I. Calvo Penadés, MD, PhD, Paediatric Rheumatology Department, Hospital Universitario La Fe; I. Nikishina, MD, PhD, Pediatric Department, V.A. Nasonova Research Institute of Rheumatology; N. Rubio-Pérez, MD, Department of Pediatrics, Hospital Universitario Dr. J.E. González, Universidad Autónoma de Nuevo; S. Oliveira, MD, Universidade Federal do Rio de Janeiro, IPPMG; K. Kobusinska, MD, Wojewodzki Szpital Dzieciecy, Oddzial Pediatrii, Hematologii Onkologii i Reumatologii; H. Schmeling, MD, Department of Pediatrics, Alberta Children’s Hospital and University of Calgary; F. Sztajnbok, MD, Hospital Universitario Pedro Ernesto, Nucleo de Estudos da Saúde do Adolescente, Universidade do Estado do Rio de Janeiro; F. Weller-Heinemann, MD, Klinikum Bremen-Mitte, Professor Hess-Kinderklinik, Pädiatrische Intensivmedizin; E. Zholobova, MD, Department of Pediatric Rheumatology, Hospital of Childhood Diseases, JCA-UNIT, Sechenov Moscow Medical Academy; F. Zulian, MD, Rheumatology Unit, Department of Woman and Child Health, University of Padua; R. Allen, MD, Royal Children’s Hospital, Pediatric Rheumatology; J. Chaitow, MD, Department of Rheumatology, Sydney Children’s Hospital Network; J. Frane, PhD, Consultant; C. Wells, Roche Products Ltd.; N. Ruperto, MD, MPH, Istituto Giannina Gaslini, Pediatria II, Rheumatologia, PRINTO Coordinating Centre; F. De Benedetti, MD, PhD, IRCCS Ospedale Pediatrico Bambino Gesù. Address correspondence to Dr. F. De Benedetti, IRCCS Ospedale Pediatrico Bambino Gesù, Piazza S. Onofrio 4, 00165 Rome, Italy. E-mail: fabrizio.debenedetti@opbg.net. Full Release Article. For details see Reprints and Permissions at jrheum.org. Accepted for publication February 16, 2018.
Heinrike Schmeling
From Genentech, San Francisco; Consultant, Santa Monica, California, USA; Division of Rheumatology, Department of Pediatrics, University of Cincinnati, Cincinnati Children’s Hospital Medical Center (CCHMC), Pediatric Rheumatology Collaborative Study Group (PRCSG) Coordinating Center, Cincinnati, Ohio, USA; Paediatric Rheumatology Department, Hospital Universitario La Fe, Valencia, Spain; Pediatric Department, V.A. Nasonova Research Institute of Rheumatology; Department of Pediatric Rheumatology, Hospital of Childhood Diseases, JCA-UNIT, Sechenov Moscow Medical Academy, Moscow, Russia; Department of Pediatrics, Hospital Universitario Dr. J.E. González, Universidad Autónoma de Nuevo, Monterrey, Mexico; Universidade Federal do Rio de Janeiro, Instituto de Puericultura e Pediatria Martagao Gesteira (IPPMG); Hospital Universitario Pedro Ernesto, Nucleo de Estudos da Saúde do Adolescente, Universidade do Estado do Rio de Janeiro, Rio de Janeiro, Brazil; Wojewodzki Szpital Dzieciecy, Oddzial Pediatrii, Hematologii Onkologii i Reumatologii, Bydgoszcz, Poland; Department of Pediatrics, Alberta Children’s Hospital and University of Calgary, Calgary, Alberta, Canada; Klinikum Bremen-Mitte, Professor Hess-Kinderklinik, Pädiatrische Intensivmedizin, Bremen, Germany; Rheumatology Unit, Department of Woman and Child Health, University of Padua, Padua; Istituto Giannina Gaslini, Pediatria II, Rheumatologia, Paediatric Rheumatology International Trials Organisation (PRINTO) Coordinating Centre, Genoa; Institute for Research and Health Care (IRCCS) Ospedale Pediatrico Bambino Gesù, Rome, Italy; Royal Children’s Hospital, Pediatric Rheumatology, Melbourne, Victoria; Department of Rheumatology, Sydney Children’s Hospital Network, Randwick and Westmead, Sydney, Australia; Roche Products Ltd., Welwyn Garden City, UK. The study was funded by F. Hoffmann-La Roche Ltd. Writing and editorial services were provided by ApotheCom and funded by F. Hoffmann-La Roche Ltd. K.N. Bharucha is an employee of Genentech. H.I. Brunner reports funding from F. Hoffmann-La Roche Ltd. She is employed by CCHMC, which served as the North American PRCSG Coordinating Center. She is on the speaker’s bureau of Genentech and serves as a consultant. I. Nikishina reports other funding from F. Hoffmann-La Roche Ltd. K. Kobusinska reports other funding from F. Hoffmann-La Roche Ltd. H. Schmeling reports grants from F. Hoffmann-La Roche Ltd., Janssen, Pfizer, and UCB Biosciences GmbH. J. Frane was a consultant for Genentech and has been employed as a consultant or an employee of Roche/Genentech. C. Wells is an employee of and owns shares in Roche. F. De Benedetti reports grants from Novartis, Roche, Pfizer, and Sanofi. K.N. Bharucha, PhD, MD, Genentech; H.I. Brunner, MD, MSc, Division of Rheumatology, Department of Pediatrics, University of Cincinnati, CCHMC, PRCSG Coordinating Center; I. Calvo Penadés, MD, PhD, Paediatric Rheumatology Department, Hospital Universitario La Fe; I. Nikishina, MD, PhD, Pediatric Department, V.A. Nasonova Research Institute of Rheumatology; N. Rubio-Pérez, MD, Department of Pediatrics, Hospital Universitario Dr. J.E. González, Universidad Autónoma de Nuevo; S. Oliveira, MD, Universidade Federal do Rio de Janeiro, IPPMG; K. Kobusinska, MD, Wojewodzki Szpital Dzieciecy, Oddzial Pediatrii, Hematologii Onkologii i Reumatologii; H. Schmeling, MD, Department of Pediatrics, Alberta Children’s Hospital and University of Calgary; F. Sztajnbok, MD, Hospital Universitario Pedro Ernesto, Nucleo de Estudos da Saúde do Adolescente, Universidade do Estado do Rio de Janeiro; F. Weller-Heinemann, MD, Klinikum Bremen-Mitte, Professor Hess-Kinderklinik, Pädiatrische Intensivmedizin; E. Zholobova, MD, Department of Pediatric Rheumatology, Hospital of Childhood Diseases, JCA-UNIT, Sechenov Moscow Medical Academy; F. Zulian, MD, Rheumatology Unit, Department of Woman and Child Health, University of Padua; R. Allen, MD, Royal Children’s Hospital, Pediatric Rheumatology; J. Chaitow, MD, Department of Rheumatology, Sydney Children’s Hospital Network; J. Frane, PhD, Consultant; C. Wells, Roche Products Ltd.; N. Ruperto, MD, MPH, Istituto Giannina Gaslini, Pediatria II, Rheumatologia, PRINTO Coordinating Centre; F. De Benedetti, MD, PhD, IRCCS Ospedale Pediatrico Bambino Gesù. Address correspondence to Dr. F. De Benedetti, IRCCS Ospedale Pediatrico Bambino Gesù, Piazza S. Onofrio 4, 00165 Rome, Italy. E-mail: fabrizio.debenedetti@opbg.net. Full Release Article. For details see Reprints and Permissions at jrheum.org. Accepted for publication February 16, 2018.
Flavio Sztajnbok
From Genentech, San Francisco; Consultant, Santa Monica, California, USA; Division of Rheumatology, Department of Pediatrics, University of Cincinnati, Cincinnati Children’s Hospital Medical Center (CCHMC), Pediatric Rheumatology Collaborative Study Group (PRCSG) Coordinating Center, Cincinnati, Ohio, USA; Paediatric Rheumatology Department, Hospital Universitario La Fe, Valencia, Spain; Pediatric Department, V.A. Nasonova Research Institute of Rheumatology; Department of Pediatric Rheumatology, Hospital of Childhood Diseases, JCA-UNIT, Sechenov Moscow Medical Academy, Moscow, Russia; Department of Pediatrics, Hospital Universitario Dr. J.E. González, Universidad Autónoma de Nuevo, Monterrey, Mexico; Universidade Federal do Rio de Janeiro, Instituto de Puericultura e Pediatria Martagao Gesteira (IPPMG); Hospital Universitario Pedro Ernesto, Nucleo de Estudos da Saúde do Adolescente, Universidade do Estado do Rio de Janeiro, Rio de Janeiro, Brazil; Wojewodzki Szpital Dzieciecy, Oddzial Pediatrii, Hematologii Onkologii i Reumatologii, Bydgoszcz, Poland; Department of Pediatrics, Alberta Children’s Hospital and University of Calgary, Calgary, Alberta, Canada; Klinikum Bremen-Mitte, Professor Hess-Kinderklinik, Pädiatrische Intensivmedizin, Bremen, Germany; Rheumatology Unit, Department of Woman and Child Health, University of Padua, Padua; Istituto Giannina Gaslini, Pediatria II, Rheumatologia, Paediatric Rheumatology International Trials Organisation (PRINTO) Coordinating Centre, Genoa; Institute for Research and Health Care (IRCCS) Ospedale Pediatrico Bambino Gesù, Rome, Italy; Royal Children’s Hospital, Pediatric Rheumatology, Melbourne, Victoria; Department of Rheumatology, Sydney Children’s Hospital Network, Randwick and Westmead, Sydney, Australia; Roche Products Ltd., Welwyn Garden City, UK. The study was funded by F. Hoffmann-La Roche Ltd. Writing and editorial services were provided by ApotheCom and funded by F. Hoffmann-La Roche Ltd. K.N. Bharucha is an employee of Genentech. H.I. Brunner reports funding from F. Hoffmann-La Roche Ltd. She is employed by CCHMC, which served as the North American PRCSG Coordinating Center. She is on the speaker’s bureau of Genentech and serves as a consultant. I. Nikishina reports other funding from F. Hoffmann-La Roche Ltd. K. Kobusinska reports other funding from F. Hoffmann-La Roche Ltd. H. Schmeling reports grants from F. Hoffmann-La Roche Ltd., Janssen, Pfizer, and UCB Biosciences GmbH. J. Frane was a consultant for Genentech and has been employed as a consultant or an employee of Roche/Genentech. C. Wells is an employee of and owns shares in Roche. F. De Benedetti reports grants from Novartis, Roche, Pfizer, and Sanofi. K.N. Bharucha, PhD, MD, Genentech; H.I. Brunner, MD, MSc, Division of Rheumatology, Department of Pediatrics, University of Cincinnati, CCHMC, PRCSG Coordinating Center; I. Calvo Penadés, MD, PhD, Paediatric Rheumatology Department, Hospital Universitario La Fe; I. Nikishina, MD, PhD, Pediatric Department, V.A. Nasonova Research Institute of Rheumatology; N. Rubio-Pérez, MD, Department of Pediatrics, Hospital Universitario Dr. J.E. González, Universidad Autónoma de Nuevo; S. Oliveira, MD, Universidade Federal do Rio de Janeiro, IPPMG; K. Kobusinska, MD, Wojewodzki Szpital Dzieciecy, Oddzial Pediatrii, Hematologii Onkologii i Reumatologii; H. Schmeling, MD, Department of Pediatrics, Alberta Children’s Hospital and University of Calgary; F. Sztajnbok, MD, Hospital Universitario Pedro Ernesto, Nucleo de Estudos da Saúde do Adolescente, Universidade do Estado do Rio de Janeiro; F. Weller-Heinemann, MD, Klinikum Bremen-Mitte, Professor Hess-Kinderklinik, Pädiatrische Intensivmedizin; E. Zholobova, MD, Department of Pediatric Rheumatology, Hospital of Childhood Diseases, JCA-UNIT, Sechenov Moscow Medical Academy; F. Zulian, MD, Rheumatology Unit, Department of Woman and Child Health, University of Padua; R. Allen, MD, Royal Children’s Hospital, Pediatric Rheumatology; J. Chaitow, MD, Department of Rheumatology, Sydney Children’s Hospital Network; J. Frane, PhD, Consultant; C. Wells, Roche Products Ltd.; N. Ruperto, MD, MPH, Istituto Giannina Gaslini, Pediatria II, Rheumatologia, PRINTO Coordinating Centre; F. De Benedetti, MD, PhD, IRCCS Ospedale Pediatrico Bambino Gesù. Address correspondence to Dr. F. De Benedetti, IRCCS Ospedale Pediatrico Bambino Gesù, Piazza S. Onofrio 4, 00165 Rome, Italy. E-mail: fabrizio.debenedetti@opbg.net. Full Release Article. For details see Reprints and Permissions at jrheum.org. Accepted for publication February 16, 2018.
Frank Weller-Heinemann
From Genentech, San Francisco; Consultant, Santa Monica, California, USA; Division of Rheumatology, Department of Pediatrics, University of Cincinnati, Cincinnati Children’s Hospital Medical Center (CCHMC), Pediatric Rheumatology Collaborative Study Group (PRCSG) Coordinating Center, Cincinnati, Ohio, USA; Paediatric Rheumatology Department, Hospital Universitario La Fe, Valencia, Spain; Pediatric Department, V.A. Nasonova Research Institute of Rheumatology; Department of Pediatric Rheumatology, Hospital of Childhood Diseases, JCA-UNIT, Sechenov Moscow Medical Academy, Moscow, Russia; Department of Pediatrics, Hospital Universitario Dr. J.E. González, Universidad Autónoma de Nuevo, Monterrey, Mexico; Universidade Federal do Rio de Janeiro, Instituto de Puericultura e Pediatria Martagao Gesteira (IPPMG); Hospital Universitario Pedro Ernesto, Nucleo de Estudos da Saúde do Adolescente, Universidade do Estado do Rio de Janeiro, Rio de Janeiro, Brazil; Wojewodzki Szpital Dzieciecy, Oddzial Pediatrii, Hematologii Onkologii i Reumatologii, Bydgoszcz, Poland; Department of Pediatrics, Alberta Children’s Hospital and University of Calgary, Calgary, Alberta, Canada; Klinikum Bremen-Mitte, Professor Hess-Kinderklinik, Pädiatrische Intensivmedizin, Bremen, Germany; Rheumatology Unit, Department of Woman and Child Health, University of Padua, Padua; Istituto Giannina Gaslini, Pediatria II, Rheumatologia, Paediatric Rheumatology International Trials Organisation (PRINTO) Coordinating Centre, Genoa; Institute for Research and Health Care (IRCCS) Ospedale Pediatrico Bambino Gesù, Rome, Italy; Royal Children’s Hospital, Pediatric Rheumatology, Melbourne, Victoria; Department of Rheumatology, Sydney Children’s Hospital Network, Randwick and Westmead, Sydney, Australia; Roche Products Ltd., Welwyn Garden City, UK. The study was funded by F. Hoffmann-La Roche Ltd. Writing and editorial services were provided by ApotheCom and funded by F. Hoffmann-La Roche Ltd. K.N. Bharucha is an employee of Genentech. H.I. Brunner reports funding from F. Hoffmann-La Roche Ltd. She is employed by CCHMC, which served as the North American PRCSG Coordinating Center. She is on the speaker’s bureau of Genentech and serves as a consultant. I. Nikishina reports other funding from F. Hoffmann-La Roche Ltd. K. Kobusinska reports other funding from F. Hoffmann-La Roche Ltd. H. Schmeling reports grants from F. Hoffmann-La Roche Ltd., Janssen, Pfizer, and UCB Biosciences GmbH. J. Frane was a consultant for Genentech and has been employed as a consultant or an employee of Roche/Genentech. C. Wells is an employee of and owns shares in Roche. F. De Benedetti reports grants from Novartis, Roche, Pfizer, and Sanofi. K.N. Bharucha, PhD, MD, Genentech; H.I. Brunner, MD, MSc, Division of Rheumatology, Department of Pediatrics, University of Cincinnati, CCHMC, PRCSG Coordinating Center; I. Calvo Penadés, MD, PhD, Paediatric Rheumatology Department, Hospital Universitario La Fe; I. Nikishina, MD, PhD, Pediatric Department, V.A. Nasonova Research Institute of Rheumatology; N. Rubio-Pérez, MD, Department of Pediatrics, Hospital Universitario Dr. J.E. González, Universidad Autónoma de Nuevo; S. Oliveira, MD, Universidade Federal do Rio de Janeiro, IPPMG; K. Kobusinska, MD, Wojewodzki Szpital Dzieciecy, Oddzial Pediatrii, Hematologii Onkologii i Reumatologii; H. Schmeling, MD, Department of Pediatrics, Alberta Children’s Hospital and University of Calgary; F. Sztajnbok, MD, Hospital Universitario Pedro Ernesto, Nucleo de Estudos da Saúde do Adolescente, Universidade do Estado do Rio de Janeiro; F. Weller-Heinemann, MD, Klinikum Bremen-Mitte, Professor Hess-Kinderklinik, Pädiatrische Intensivmedizin; E. Zholobova, MD, Department of Pediatric Rheumatology, Hospital of Childhood Diseases, JCA-UNIT, Sechenov Moscow Medical Academy; F. Zulian, MD, Rheumatology Unit, Department of Woman and Child Health, University of Padua; R. Allen, MD, Royal Children’s Hospital, Pediatric Rheumatology; J. Chaitow, MD, Department of Rheumatology, Sydney Children’s Hospital Network; J. Frane, PhD, Consultant; C. Wells, Roche Products Ltd.; N. Ruperto, MD, MPH, Istituto Giannina Gaslini, Pediatria II, Rheumatologia, PRINTO Coordinating Centre; F. De Benedetti, MD, PhD, IRCCS Ospedale Pediatrico Bambino Gesù. Address correspondence to Dr. F. De Benedetti, IRCCS Ospedale Pediatrico Bambino Gesù, Piazza S. Onofrio 4, 00165 Rome, Italy. E-mail: fabrizio.debenedetti@opbg.net. Full Release Article. For details see Reprints and Permissions at jrheum.org. Accepted for publication February 16, 2018.
Elena Zholobova
From Genentech, San Francisco; Consultant, Santa Monica, California, USA; Division of Rheumatology, Department of Pediatrics, University of Cincinnati, Cincinnati Children’s Hospital Medical Center (CCHMC), Pediatric Rheumatology Collaborative Study Group (PRCSG) Coordinating Center, Cincinnati, Ohio, USA; Paediatric Rheumatology Department, Hospital Universitario La Fe, Valencia, Spain; Pediatric Department, V.A. Nasonova Research Institute of Rheumatology; Department of Pediatric Rheumatology, Hospital of Childhood Diseases, JCA-UNIT, Sechenov Moscow Medical Academy, Moscow, Russia; Department of Pediatrics, Hospital Universitario Dr. J.E. González, Universidad Autónoma de Nuevo, Monterrey, Mexico; Universidade Federal do Rio de Janeiro, Instituto de Puericultura e Pediatria Martagao Gesteira (IPPMG); Hospital Universitario Pedro Ernesto, Nucleo de Estudos da Saúde do Adolescente, Universidade do Estado do Rio de Janeiro, Rio de Janeiro, Brazil; Wojewodzki Szpital Dzieciecy, Oddzial Pediatrii, Hematologii Onkologii i Reumatologii, Bydgoszcz, Poland; Department of Pediatrics, Alberta Children’s Hospital and University of Calgary, Calgary, Alberta, Canada; Klinikum Bremen-Mitte, Professor Hess-Kinderklinik, Pädiatrische Intensivmedizin, Bremen, Germany; Rheumatology Unit, Department of Woman and Child Health, University of Padua, Padua; Istituto Giannina Gaslini, Pediatria II, Rheumatologia, Paediatric Rheumatology International Trials Organisation (PRINTO) Coordinating Centre, Genoa; Institute for Research and Health Care (IRCCS) Ospedale Pediatrico Bambino Gesù, Rome, Italy; Royal Children’s Hospital, Pediatric Rheumatology, Melbourne, Victoria; Department of Rheumatology, Sydney Children’s Hospital Network, Randwick and Westmead, Sydney, Australia; Roche Products Ltd., Welwyn Garden City, UK. The study was funded by F. Hoffmann-La Roche Ltd. Writing and editorial services were provided by ApotheCom and funded by F. Hoffmann-La Roche Ltd. K.N. Bharucha is an employee of Genentech. H.I. Brunner reports funding from F. Hoffmann-La Roche Ltd. She is employed by CCHMC, which served as the North American PRCSG Coordinating Center. She is on the speaker’s bureau of Genentech and serves as a consultant. I. Nikishina reports other funding from F. Hoffmann-La Roche Ltd. K. Kobusinska reports other funding from F. Hoffmann-La Roche Ltd. H. Schmeling reports grants from F. Hoffmann-La Roche Ltd., Janssen, Pfizer, and UCB Biosciences GmbH. J. Frane was a consultant for Genentech and has been employed as a consultant or an employee of Roche/Genentech. C. Wells is an employee of and owns shares in Roche. F. De Benedetti reports grants from Novartis, Roche, Pfizer, and Sanofi. K.N. Bharucha, PhD, MD, Genentech; H.I. Brunner, MD, MSc, Division of Rheumatology, Department of Pediatrics, University of Cincinnati, CCHMC, PRCSG Coordinating Center; I. Calvo Penadés, MD, PhD, Paediatric Rheumatology Department, Hospital Universitario La Fe; I. Nikishina, MD, PhD, Pediatric Department, V.A. Nasonova Research Institute of Rheumatology; N. Rubio-Pérez, MD, Department of Pediatrics, Hospital Universitario Dr. J.E. González, Universidad Autónoma de Nuevo; S. Oliveira, MD, Universidade Federal do Rio de Janeiro, IPPMG; K. Kobusinska, MD, Wojewodzki Szpital Dzieciecy, Oddzial Pediatrii, Hematologii Onkologii i Reumatologii; H. Schmeling, MD, Department of Pediatrics, Alberta Children’s Hospital and University of Calgary; F. Sztajnbok, MD, Hospital Universitario Pedro Ernesto, Nucleo de Estudos da Saúde do Adolescente, Universidade do Estado do Rio de Janeiro; F. Weller-Heinemann, MD, Klinikum Bremen-Mitte, Professor Hess-Kinderklinik, Pädiatrische Intensivmedizin; E. Zholobova, MD, Department of Pediatric Rheumatology, Hospital of Childhood Diseases, JCA-UNIT, Sechenov Moscow Medical Academy; F. Zulian, MD, Rheumatology Unit, Department of Woman and Child Health, University of Padua; R. Allen, MD, Royal Children’s Hospital, Pediatric Rheumatology; J. Chaitow, MD, Department of Rheumatology, Sydney Children’s Hospital Network; J. Frane, PhD, Consultant; C. Wells, Roche Products Ltd.; N. Ruperto, MD, MPH, Istituto Giannina Gaslini, Pediatria II, Rheumatologia, PRINTO Coordinating Centre; F. De Benedetti, MD, PhD, IRCCS Ospedale Pediatrico Bambino Gesù. Address correspondence to Dr. F. De Benedetti, IRCCS Ospedale Pediatrico Bambino Gesù, Piazza S. Onofrio 4, 00165 Rome, Italy. E-mail: fabrizio.debenedetti@opbg.net. Full Release Article. For details see Reprints and Permissions at jrheum.org. Accepted for publication February 16, 2018.
Francesco Zulian
From Genentech, San Francisco; Consultant, Santa Monica, California, USA; Division of Rheumatology, Department of Pediatrics, University of Cincinnati, Cincinnati Children’s Hospital Medical Center (CCHMC), Pediatric Rheumatology Collaborative Study Group (PRCSG) Coordinating Center, Cincinnati, Ohio, USA; Paediatric Rheumatology Department, Hospital Universitario La Fe, Valencia, Spain; Pediatric Department, V.A. Nasonova Research Institute of Rheumatology; Department of Pediatric Rheumatology, Hospital of Childhood Diseases, JCA-UNIT, Sechenov Moscow Medical Academy, Moscow, Russia; Department of Pediatrics, Hospital Universitario Dr. J.E. González, Universidad Autónoma de Nuevo, Monterrey, Mexico; Universidade Federal do Rio de Janeiro, Instituto de Puericultura e Pediatria Martagao Gesteira (IPPMG); Hospital Universitario Pedro Ernesto, Nucleo de Estudos da Saúde do Adolescente, Universidade do Estado do Rio de Janeiro, Rio de Janeiro, Brazil; Wojewodzki Szpital Dzieciecy, Oddzial Pediatrii, Hematologii Onkologii i Reumatologii, Bydgoszcz, Poland; Department of Pediatrics, Alberta Children’s Hospital and University of Calgary, Calgary, Alberta, Canada; Klinikum Bremen-Mitte, Professor Hess-Kinderklinik, Pädiatrische Intensivmedizin, Bremen, Germany; Rheumatology Unit, Department of Woman and Child Health, University of Padua, Padua; Istituto Giannina Gaslini, Pediatria II, Rheumatologia, Paediatric Rheumatology International Trials Organisation (PRINTO) Coordinating Centre, Genoa; Institute for Research and Health Care (IRCCS) Ospedale Pediatrico Bambino Gesù, Rome, Italy; Royal Children’s Hospital, Pediatric Rheumatology, Melbourne, Victoria; Department of Rheumatology, Sydney Children’s Hospital Network, Randwick and Westmead, Sydney, Australia; Roche Products Ltd., Welwyn Garden City, UK. The study was funded by F. Hoffmann-La Roche Ltd. Writing and editorial services were provided by ApotheCom and funded by F. Hoffmann-La Roche Ltd. K.N. Bharucha is an employee of Genentech. H.I. Brunner reports funding from F. Hoffmann-La Roche Ltd. She is employed by CCHMC, which served as the North American PRCSG Coordinating Center. She is on the speaker’s bureau of Genentech and serves as a consultant. I. Nikishina reports other funding from F. Hoffmann-La Roche Ltd. K. Kobusinska reports other funding from F. Hoffmann-La Roche Ltd. H. Schmeling reports grants from F. Hoffmann-La Roche Ltd., Janssen, Pfizer, and UCB Biosciences GmbH. J. Frane was a consultant for Genentech and has been employed as a consultant or an employee of Roche/Genentech. C. Wells is an employee of and owns shares in Roche. F. De Benedetti reports grants from Novartis, Roche, Pfizer, and Sanofi. K.N. Bharucha, PhD, MD, Genentech; H.I. Brunner, MD, MSc, Division of Rheumatology, Department of Pediatrics, University of Cincinnati, CCHMC, PRCSG Coordinating Center; I. Calvo Penadés, MD, PhD, Paediatric Rheumatology Department, Hospital Universitario La Fe; I. Nikishina, MD, PhD, Pediatric Department, V.A. Nasonova Research Institute of Rheumatology; N. Rubio-Pérez, MD, Department of Pediatrics, Hospital Universitario Dr. J.E. González, Universidad Autónoma de Nuevo; S. Oliveira, MD, Universidade Federal do Rio de Janeiro, IPPMG; K. Kobusinska, MD, Wojewodzki Szpital Dzieciecy, Oddzial Pediatrii, Hematologii Onkologii i Reumatologii; H. Schmeling, MD, Department of Pediatrics, Alberta Children’s Hospital and University of Calgary; F. Sztajnbok, MD, Hospital Universitario Pedro Ernesto, Nucleo de Estudos da Saúde do Adolescente, Universidade do Estado do Rio de Janeiro; F. Weller-Heinemann, MD, Klinikum Bremen-Mitte, Professor Hess-Kinderklinik, Pädiatrische Intensivmedizin; E. Zholobova, MD, Department of Pediatric Rheumatology, Hospital of Childhood Diseases, JCA-UNIT, Sechenov Moscow Medical Academy; F. Zulian, MD, Rheumatology Unit, Department of Woman and Child Health, University of Padua; R. Allen, MD, Royal Children’s Hospital, Pediatric Rheumatology; J. Chaitow, MD, Department of Rheumatology, Sydney Children’s Hospital Network; J. Frane, PhD, Consultant; C. Wells, Roche Products Ltd.; N. Ruperto, MD, MPH, Istituto Giannina Gaslini, Pediatria II, Rheumatologia, PRINTO Coordinating Centre; F. De Benedetti, MD, PhD, IRCCS Ospedale Pediatrico Bambino Gesù. Address correspondence to Dr. F. De Benedetti, IRCCS Ospedale Pediatrico Bambino Gesù, Piazza S. Onofrio 4, 00165 Rome, Italy. E-mail: fabrizio.debenedetti@opbg.net. Full Release Article. For details see Reprints and Permissions at jrheum.org. Accepted for publication February 16, 2018.
Roger Allen
From Genentech, San Francisco; Consultant, Santa Monica, California, USA; Division of Rheumatology, Department of Pediatrics, University of Cincinnati, Cincinnati Children’s Hospital Medical Center (CCHMC), Pediatric Rheumatology Collaborative Study Group (PRCSG) Coordinating Center, Cincinnati, Ohio, USA; Paediatric Rheumatology Department, Hospital Universitario La Fe, Valencia, Spain; Pediatric Department, V.A. Nasonova Research Institute of Rheumatology; Department of Pediatric Rheumatology, Hospital of Childhood Diseases, JCA-UNIT, Sechenov Moscow Medical Academy, Moscow, Russia; Department of Pediatrics, Hospital Universitario Dr. J.E. González, Universidad Autónoma de Nuevo, Monterrey, Mexico; Universidade Federal do Rio de Janeiro, Instituto de Puericultura e Pediatria Martagao Gesteira (IPPMG); Hospital Universitario Pedro Ernesto, Nucleo de Estudos da Saúde do Adolescente, Universidade do Estado do Rio de Janeiro, Rio de Janeiro, Brazil; Wojewodzki Szpital Dzieciecy, Oddzial Pediatrii, Hematologii Onkologii i Reumatologii, Bydgoszcz, Poland; Department of Pediatrics, Alberta Children’s Hospital and University of Calgary, Calgary, Alberta, Canada; Klinikum Bremen-Mitte, Professor Hess-Kinderklinik, Pädiatrische Intensivmedizin, Bremen, Germany; Rheumatology Unit, Department of Woman and Child Health, University of Padua, Padua; Istituto Giannina Gaslini, Pediatria II, Rheumatologia, Paediatric Rheumatology International Trials Organisation (PRINTO) Coordinating Centre, Genoa; Institute for Research and Health Care (IRCCS) Ospedale Pediatrico Bambino Gesù, Rome, Italy; Royal Children’s Hospital, Pediatric Rheumatology, Melbourne, Victoria; Department of Rheumatology, Sydney Children’s Hospital Network, Randwick and Westmead, Sydney, Australia; Roche Products Ltd., Welwyn Garden City, UK. The study was funded by F. Hoffmann-La Roche Ltd. Writing and editorial services were provided by ApotheCom and funded by F. Hoffmann-La Roche Ltd. K.N. Bharucha is an employee of Genentech. H.I. Brunner reports funding from F. Hoffmann-La Roche Ltd. She is employed by CCHMC, which served as the North American PRCSG Coordinating Center. She is on the speaker’s bureau of Genentech and serves as a consultant. I. Nikishina reports other funding from F. Hoffmann-La Roche Ltd. K. Kobusinska reports other funding from F. Hoffmann-La Roche Ltd. H. Schmeling reports grants from F. Hoffmann-La Roche Ltd., Janssen, Pfizer, and UCB Biosciences GmbH. J. Frane was a consultant for Genentech and has been employed as a consultant or an employee of Roche/Genentech. C. Wells is an employee of and owns shares in Roche. F. De Benedetti reports grants from Novartis, Roche, Pfizer, and Sanofi. K.N. Bharucha, PhD, MD, Genentech; H.I. Brunner, MD, MSc, Division of Rheumatology, Department of Pediatrics, University of Cincinnati, CCHMC, PRCSG Coordinating Center; I. Calvo Penadés, MD, PhD, Paediatric Rheumatology Department, Hospital Universitario La Fe; I. Nikishina, MD, PhD, Pediatric Department, V.A. Nasonova Research Institute of Rheumatology; N. Rubio-Pérez, MD, Department of Pediatrics, Hospital Universitario Dr. J.E. González, Universidad Autónoma de Nuevo; S. Oliveira, MD, Universidade Federal do Rio de Janeiro, IPPMG; K. Kobusinska, MD, Wojewodzki Szpital Dzieciecy, Oddzial Pediatrii, Hematologii Onkologii i Reumatologii; H. Schmeling, MD, Department of Pediatrics, Alberta Children’s Hospital and University of Calgary; F. Sztajnbok, MD, Hospital Universitario Pedro Ernesto, Nucleo de Estudos da Saúde do Adolescente, Universidade do Estado do Rio de Janeiro; F. Weller-Heinemann, MD, Klinikum Bremen-Mitte, Professor Hess-Kinderklinik, Pädiatrische Intensivmedizin; E. Zholobova, MD, Department of Pediatric Rheumatology, Hospital of Childhood Diseases, JCA-UNIT, Sechenov Moscow Medical Academy; F. Zulian, MD, Rheumatology Unit, Department of Woman and Child Health, University of Padua; R. Allen, MD, Royal Children’s Hospital, Pediatric Rheumatology; J. Chaitow, MD, Department of Rheumatology, Sydney Children’s Hospital Network; J. Frane, PhD, Consultant; C. Wells, Roche Products Ltd.; N. Ruperto, MD, MPH, Istituto Giannina Gaslini, Pediatria II, Rheumatologia, PRINTO Coordinating Centre; F. De Benedetti, MD, PhD, IRCCS Ospedale Pediatrico Bambino Gesù. Address correspondence to Dr. F. De Benedetti, IRCCS Ospedale Pediatrico Bambino Gesù, Piazza S. Onofrio 4, 00165 Rome, Italy. E-mail: fabrizio.debenedetti@opbg.net. Full Release Article. For details see Reprints and Permissions at jrheum.org. Accepted for publication February 16, 2018.
Jeffrey Chaitow
From Genentech, San Francisco; Consultant, Santa Monica, California, USA; Division of Rheumatology, Department of Pediatrics, University of Cincinnati, Cincinnati Children’s Hospital Medical Center (CCHMC), Pediatric Rheumatology Collaborative Study Group (PRCSG) Coordinating Center, Cincinnati, Ohio, USA; Paediatric Rheumatology Department, Hospital Universitario La Fe, Valencia, Spain; Pediatric Department, V.A. Nasonova Research Institute of Rheumatology; Department of Pediatric Rheumatology, Hospital of Childhood Diseases, JCA-UNIT, Sechenov Moscow Medical Academy, Moscow, Russia; Department of Pediatrics, Hospital Universitario Dr. J.E. González, Universidad Autónoma de Nuevo, Monterrey, Mexico; Universidade Federal do Rio de Janeiro, Instituto de Puericultura e Pediatria Martagao Gesteira (IPPMG); Hospital Universitario Pedro Ernesto, Nucleo de Estudos da Saúde do Adolescente, Universidade do Estado do Rio de Janeiro, Rio de Janeiro, Brazil; Wojewodzki Szpital Dzieciecy, Oddzial Pediatrii, Hematologii Onkologii i Reumatologii, Bydgoszcz, Poland; Department of Pediatrics, Alberta Children’s Hospital and University of Calgary, Calgary, Alberta, Canada; Klinikum Bremen-Mitte, Professor Hess-Kinderklinik, Pädiatrische Intensivmedizin, Bremen, Germany; Rheumatology Unit, Department of Woman and Child Health, University of Padua, Padua; Istituto Giannina Gaslini, Pediatria II, Rheumatologia, Paediatric Rheumatology International Trials Organisation (PRINTO) Coordinating Centre, Genoa; Institute for Research and Health Care (IRCCS) Ospedale Pediatrico Bambino Gesù, Rome, Italy; Royal Children’s Hospital, Pediatric Rheumatology, Melbourne, Victoria; Department of Rheumatology, Sydney Children’s Hospital Network, Randwick and Westmead, Sydney, Australia; Roche Products Ltd., Welwyn Garden City, UK. The study was funded by F. Hoffmann-La Roche Ltd. Writing and editorial services were provided by ApotheCom and funded by F. Hoffmann-La Roche Ltd. K.N. Bharucha is an employee of Genentech. H.I. Brunner reports funding from F. Hoffmann-La Roche Ltd. She is employed by CCHMC, which served as the North American PRCSG Coordinating Center. She is on the speaker’s bureau of Genentech and serves as a consultant. I. Nikishina reports other funding from F. Hoffmann-La Roche Ltd. K. Kobusinska reports other funding from F. Hoffmann-La Roche Ltd. H. Schmeling reports grants from F. Hoffmann-La Roche Ltd., Janssen, Pfizer, and UCB Biosciences GmbH. J. Frane was a consultant for Genentech and has been employed as a consultant or an employee of Roche/Genentech. C. Wells is an employee of and owns shares in Roche. F. De Benedetti reports grants from Novartis, Roche, Pfizer, and Sanofi. K.N. Bharucha, PhD, MD, Genentech; H.I. Brunner, MD, MSc, Division of Rheumatology, Department of Pediatrics, University of Cincinnati, CCHMC, PRCSG Coordinating Center; I. Calvo Penadés, MD, PhD, Paediatric Rheumatology Department, Hospital Universitario La Fe; I. Nikishina, MD, PhD, Pediatric Department, V.A. Nasonova Research Institute of Rheumatology; N. Rubio-Pérez, MD, Department of Pediatrics, Hospital Universitario Dr. J.E. González, Universidad Autónoma de Nuevo; S. Oliveira, MD, Universidade Federal do Rio de Janeiro, IPPMG; K. Kobusinska, MD, Wojewodzki Szpital Dzieciecy, Oddzial Pediatrii, Hematologii Onkologii i Reumatologii; H. Schmeling, MD, Department of Pediatrics, Alberta Children’s Hospital and University of Calgary; F. Sztajnbok, MD, Hospital Universitario Pedro Ernesto, Nucleo de Estudos da Saúde do Adolescente, Universidade do Estado do Rio de Janeiro; F. Weller-Heinemann, MD, Klinikum Bremen-Mitte, Professor Hess-Kinderklinik, Pädiatrische Intensivmedizin; E. Zholobova, MD, Department of Pediatric Rheumatology, Hospital of Childhood Diseases, JCA-UNIT, Sechenov Moscow Medical Academy; F. Zulian, MD, Rheumatology Unit, Department of Woman and Child Health, University of Padua; R. Allen, MD, Royal Children’s Hospital, Pediatric Rheumatology; J. Chaitow, MD, Department of Rheumatology, Sydney Children’s Hospital Network; J. Frane, PhD, Consultant; C. Wells, Roche Products Ltd.; N. Ruperto, MD, MPH, Istituto Giannina Gaslini, Pediatria II, Rheumatologia, PRINTO Coordinating Centre; F. De Benedetti, MD, PhD, IRCCS Ospedale Pediatrico Bambino Gesù. Address correspondence to Dr. F. De Benedetti, IRCCS Ospedale Pediatrico Bambino Gesù, Piazza S. Onofrio 4, 00165 Rome, Italy. E-mail: fabrizio.debenedetti@opbg.net. Full Release Article. For details see Reprints and Permissions at jrheum.org. Accepted for publication February 16, 2018.
James Frane
From Genentech, San Francisco; Consultant, Santa Monica, California, USA; Division of Rheumatology, Department of Pediatrics, University of Cincinnati, Cincinnati Children’s Hospital Medical Center (CCHMC), Pediatric Rheumatology Collaborative Study Group (PRCSG) Coordinating Center, Cincinnati, Ohio, USA; Paediatric Rheumatology Department, Hospital Universitario La Fe, Valencia, Spain; Pediatric Department, V.A. Nasonova Research Institute of Rheumatology; Department of Pediatric Rheumatology, Hospital of Childhood Diseases, JCA-UNIT, Sechenov Moscow Medical Academy, Moscow, Russia; Department of Pediatrics, Hospital Universitario Dr. J.E. González, Universidad Autónoma de Nuevo, Monterrey, Mexico; Universidade Federal do Rio de Janeiro, Instituto de Puericultura e Pediatria Martagao Gesteira (IPPMG); Hospital Universitario Pedro Ernesto, Nucleo de Estudos da Saúde do Adolescente, Universidade do Estado do Rio de Janeiro, Rio de Janeiro, Brazil; Wojewodzki Szpital Dzieciecy, Oddzial Pediatrii, Hematologii Onkologii i Reumatologii, Bydgoszcz, Poland; Department of Pediatrics, Alberta Children’s Hospital and University of Calgary, Calgary, Alberta, Canada; Klinikum Bremen-Mitte, Professor Hess-Kinderklinik, Pädiatrische Intensivmedizin, Bremen, Germany; Rheumatology Unit, Department of Woman and Child Health, University of Padua, Padua; Istituto Giannina Gaslini, Pediatria II, Rheumatologia, Paediatric Rheumatology International Trials Organisation (PRINTO) Coordinating Centre, Genoa; Institute for Research and Health Care (IRCCS) Ospedale Pediatrico Bambino Gesù, Rome, Italy; Royal Children’s Hospital, Pediatric Rheumatology, Melbourne, Victoria; Department of Rheumatology, Sydney Children’s Hospital Network, Randwick and Westmead, Sydney, Australia; Roche Products Ltd., Welwyn Garden City, UK. The study was funded by F. Hoffmann-La Roche Ltd. Writing and editorial services were provided by ApotheCom and funded by F. Hoffmann-La Roche Ltd. K.N. Bharucha is an employee of Genentech. H.I. Brunner reports funding from F. Hoffmann-La Roche Ltd. She is employed by CCHMC, which served as the North American PRCSG Coordinating Center. She is on the speaker’s bureau of Genentech and serves as a consultant. I. Nikishina reports other funding from F. Hoffmann-La Roche Ltd. K. Kobusinska reports other funding from F. Hoffmann-La Roche Ltd. H. Schmeling reports grants from F. Hoffmann-La Roche Ltd., Janssen, Pfizer, and UCB Biosciences GmbH. J. Frane was a consultant for Genentech and has been employed as a consultant or an employee of Roche/Genentech. C. Wells is an employee of and owns shares in Roche. F. De Benedetti reports grants from Novartis, Roche, Pfizer, and Sanofi. K.N. Bharucha, PhD, MD, Genentech; H.I. Brunner, MD, MSc, Division of Rheumatology, Department of Pediatrics, University of Cincinnati, CCHMC, PRCSG Coordinating Center; I. Calvo Penadés, MD, PhD, Paediatric Rheumatology Department, Hospital Universitario La Fe; I. Nikishina, MD, PhD, Pediatric Department, V.A. Nasonova Research Institute of Rheumatology; N. Rubio-Pérez, MD, Department of Pediatrics, Hospital Universitario Dr. J.E. González, Universidad Autónoma de Nuevo; S. Oliveira, MD, Universidade Federal do Rio de Janeiro, IPPMG; K. Kobusinska, MD, Wojewodzki Szpital Dzieciecy, Oddzial Pediatrii, Hematologii Onkologii i Reumatologii; H. Schmeling, MD, Department of Pediatrics, Alberta Children’s Hospital and University of Calgary; F. Sztajnbok, MD, Hospital Universitario Pedro Ernesto, Nucleo de Estudos da Saúde do Adolescente, Universidade do Estado do Rio de Janeiro; F. Weller-Heinemann, MD, Klinikum Bremen-Mitte, Professor Hess-Kinderklinik, Pädiatrische Intensivmedizin; E. Zholobova, MD, Department of Pediatric Rheumatology, Hospital of Childhood Diseases, JCA-UNIT, Sechenov Moscow Medical Academy; F. Zulian, MD, Rheumatology Unit, Department of Woman and Child Health, University of Padua; R. Allen, MD, Royal Children’s Hospital, Pediatric Rheumatology; J. Chaitow, MD, Department of Rheumatology, Sydney Children’s Hospital Network; J. Frane, PhD, Consultant; C. Wells, Roche Products Ltd.; N. Ruperto, MD, MPH, Istituto Giannina Gaslini, Pediatria II, Rheumatologia, PRINTO Coordinating Centre; F. De Benedetti, MD, PhD, IRCCS Ospedale Pediatrico Bambino Gesù. Address correspondence to Dr. F. De Benedetti, IRCCS Ospedale Pediatrico Bambino Gesù, Piazza S. Onofrio 4, 00165 Rome, Italy. E-mail: fabrizio.debenedetti@opbg.net. Full Release Article. For details see Reprints and Permissions at jrheum.org. Accepted for publication February 16, 2018.
Chris Wells
From Genentech, San Francisco; Consultant, Santa Monica, California, USA; Division of Rheumatology, Department of Pediatrics, University of Cincinnati, Cincinnati Children’s Hospital Medical Center (CCHMC), Pediatric Rheumatology Collaborative Study Group (PRCSG) Coordinating Center, Cincinnati, Ohio, USA; Paediatric Rheumatology Department, Hospital Universitario La Fe, Valencia, Spain; Pediatric Department, V.A. Nasonova Research Institute of Rheumatology; Department of Pediatric Rheumatology, Hospital of Childhood Diseases, JCA-UNIT, Sechenov Moscow Medical Academy, Moscow, Russia; Department of Pediatrics, Hospital Universitario Dr. J.E. González, Universidad Autónoma de Nuevo, Monterrey, Mexico; Universidade Federal do Rio de Janeiro, Instituto de Puericultura e Pediatria Martagao Gesteira (IPPMG); Hospital Universitario Pedro Ernesto, Nucleo de Estudos da Saúde do Adolescente, Universidade do Estado do Rio de Janeiro, Rio de Janeiro, Brazil; Wojewodzki Szpital Dzieciecy, Oddzial Pediatrii, Hematologii Onkologii i Reumatologii, Bydgoszcz, Poland; Department of Pediatrics, Alberta Children’s Hospital and University of Calgary, Calgary, Alberta, Canada; Klinikum Bremen-Mitte, Professor Hess-Kinderklinik, Pädiatrische Intensivmedizin, Bremen, Germany; Rheumatology Unit, Department of Woman and Child Health, University of Padua, Padua; Istituto Giannina Gaslini, Pediatria II, Rheumatologia, Paediatric Rheumatology International Trials Organisation (PRINTO) Coordinating Centre, Genoa; Institute for Research and Health Care (IRCCS) Ospedale Pediatrico Bambino Gesù, Rome, Italy; Royal Children’s Hospital, Pediatric Rheumatology, Melbourne, Victoria; Department of Rheumatology, Sydney Children’s Hospital Network, Randwick and Westmead, Sydney, Australia; Roche Products Ltd., Welwyn Garden City, UK. The study was funded by F. Hoffmann-La Roche Ltd. Writing and editorial services were provided by ApotheCom and funded by F. Hoffmann-La Roche Ltd. K.N. Bharucha is an employee of Genentech. H.I. Brunner reports funding from F. Hoffmann-La Roche Ltd. She is employed by CCHMC, which served as the North American PRCSG Coordinating Center. She is on the speaker’s bureau of Genentech and serves as a consultant. I. Nikishina reports other funding from F. Hoffmann-La Roche Ltd. K. Kobusinska reports other funding from F. Hoffmann-La Roche Ltd. H. Schmeling reports grants from F. Hoffmann-La Roche Ltd., Janssen, Pfizer, and UCB Biosciences GmbH. J. Frane was a consultant for Genentech and has been employed as a consultant or an employee of Roche/Genentech. C. Wells is an employee of and owns shares in Roche. F. De Benedetti reports grants from Novartis, Roche, Pfizer, and Sanofi. K.N. Bharucha, PhD, MD, Genentech; H.I. Brunner, MD, MSc, Division of Rheumatology, Department of Pediatrics, University of Cincinnati, CCHMC, PRCSG Coordinating Center; I. Calvo Penadés, MD, PhD, Paediatric Rheumatology Department, Hospital Universitario La Fe; I. Nikishina, MD, PhD, Pediatric Department, V.A. Nasonova Research Institute of Rheumatology; N. Rubio-Pérez, MD, Department of Pediatrics, Hospital Universitario Dr. J.E. González, Universidad Autónoma de Nuevo; S. Oliveira, MD, Universidade Federal do Rio de Janeiro, IPPMG; K. Kobusinska, MD, Wojewodzki Szpital Dzieciecy, Oddzial Pediatrii, Hematologii Onkologii i Reumatologii; H. Schmeling, MD, Department of Pediatrics, Alberta Children’s Hospital and University of Calgary; F. Sztajnbok, MD, Hospital Universitario Pedro Ernesto, Nucleo de Estudos da Saúde do Adolescente, Universidade do Estado do Rio de Janeiro; F. Weller-Heinemann, MD, Klinikum Bremen-Mitte, Professor Hess-Kinderklinik, Pädiatrische Intensivmedizin; E. Zholobova, MD, Department of Pediatric Rheumatology, Hospital of Childhood Diseases, JCA-UNIT, Sechenov Moscow Medical Academy; F. Zulian, MD, Rheumatology Unit, Department of Woman and Child Health, University of Padua; R. Allen, MD, Royal Children’s Hospital, Pediatric Rheumatology; J. Chaitow, MD, Department of Rheumatology, Sydney Children’s Hospital Network; J. Frane, PhD, Consultant; C. Wells, Roche Products Ltd.; N. Ruperto, MD, MPH, Istituto Giannina Gaslini, Pediatria II, Rheumatologia, PRINTO Coordinating Centre; F. De Benedetti, MD, PhD, IRCCS Ospedale Pediatrico Bambino Gesù. Address correspondence to Dr. F. De Benedetti, IRCCS Ospedale Pediatrico Bambino Gesù, Piazza S. Onofrio 4, 00165 Rome, Italy. E-mail: fabrizio.debenedetti@opbg.net. Full Release Article. For details see Reprints and Permissions at jrheum.org. Accepted for publication February 16, 2018.
Nicolino Ruperto
From Genentech, San Francisco; Consultant, Santa Monica, California, USA; Division of Rheumatology, Department of Pediatrics, University of Cincinnati, Cincinnati Children’s Hospital Medical Center (CCHMC), Pediatric Rheumatology Collaborative Study Group (PRCSG) Coordinating Center, Cincinnati, Ohio, USA; Paediatric Rheumatology Department, Hospital Universitario La Fe, Valencia, Spain; Pediatric Department, V.A. Nasonova Research Institute of Rheumatology; Department of Pediatric Rheumatology, Hospital of Childhood Diseases, JCA-UNIT, Sechenov Moscow Medical Academy, Moscow, Russia; Department of Pediatrics, Hospital Universitario Dr. J.E. González, Universidad Autónoma de Nuevo, Monterrey, Mexico; Universidade Federal do Rio de Janeiro, Instituto de Puericultura e Pediatria Martagao Gesteira (IPPMG); Hospital Universitario Pedro Ernesto, Nucleo de Estudos da Saúde do Adolescente, Universidade do Estado do Rio de Janeiro, Rio de Janeiro, Brazil; Wojewodzki Szpital Dzieciecy, Oddzial Pediatrii, Hematologii Onkologii i Reumatologii, Bydgoszcz, Poland; Department of Pediatrics, Alberta Children’s Hospital and University of Calgary, Calgary, Alberta, Canada; Klinikum Bremen-Mitte, Professor Hess-Kinderklinik, Pädiatrische Intensivmedizin, Bremen, Germany; Rheumatology Unit, Department of Woman and Child Health, University of Padua, Padua; Istituto Giannina Gaslini, Pediatria II, Rheumatologia, Paediatric Rheumatology International Trials Organisation (PRINTO) Coordinating Centre, Genoa; Institute for Research and Health Care (IRCCS) Ospedale Pediatrico Bambino Gesù, Rome, Italy; Royal Children’s Hospital, Pediatric Rheumatology, Melbourne, Victoria; Department of Rheumatology, Sydney Children’s Hospital Network, Randwick and Westmead, Sydney, Australia; Roche Products Ltd., Welwyn Garden City, UK. The study was funded by F. Hoffmann-La Roche Ltd. Writing and editorial services were provided by ApotheCom and funded by F. Hoffmann-La Roche Ltd. K.N. Bharucha is an employee of Genentech. H.I. Brunner reports funding from F. Hoffmann-La Roche Ltd. She is employed by CCHMC, which served as the North American PRCSG Coordinating Center. She is on the speaker’s bureau of Genentech and serves as a consultant. I. Nikishina reports other funding from F. Hoffmann-La Roche Ltd. K. Kobusinska reports other funding from F. Hoffmann-La Roche Ltd. H. Schmeling reports grants from F. Hoffmann-La Roche Ltd., Janssen, Pfizer, and UCB Biosciences GmbH. J. Frane was a consultant for Genentech and has been employed as a consultant or an employee of Roche/Genentech. C. Wells is an employee of and owns shares in Roche. F. De Benedetti reports grants from Novartis, Roche, Pfizer, and Sanofi. K.N. Bharucha, PhD, MD, Genentech; H.I. Brunner, MD, MSc, Division of Rheumatology, Department of Pediatrics, University of Cincinnati, CCHMC, PRCSG Coordinating Center; I. Calvo Penadés, MD, PhD, Paediatric Rheumatology Department, Hospital Universitario La Fe; I. Nikishina, MD, PhD, Pediatric Department, V.A. Nasonova Research Institute of Rheumatology; N. Rubio-Pérez, MD, Department of Pediatrics, Hospital Universitario Dr. J.E. González, Universidad Autónoma de Nuevo; S. Oliveira, MD, Universidade Federal do Rio de Janeiro, IPPMG; K. Kobusinska, MD, Wojewodzki Szpital Dzieciecy, Oddzial Pediatrii, Hematologii Onkologii i Reumatologii; H. Schmeling, MD, Department of Pediatrics, Alberta Children’s Hospital and University of Calgary; F. Sztajnbok, MD, Hospital Universitario Pedro Ernesto, Nucleo de Estudos da Saúde do Adolescente, Universidade do Estado do Rio de Janeiro; F. Weller-Heinemann, MD, Klinikum Bremen-Mitte, Professor Hess-Kinderklinik, Pädiatrische Intensivmedizin; E. Zholobova, MD, Department of Pediatric Rheumatology, Hospital of Childhood Diseases, JCA-UNIT, Sechenov Moscow Medical Academy; F. Zulian, MD, Rheumatology Unit, Department of Woman and Child Health, University of Padua; R. Allen, MD, Royal Children’s Hospital, Pediatric Rheumatology; J. Chaitow, MD, Department of Rheumatology, Sydney Children’s Hospital Network; J. Frane, PhD, Consultant; C. Wells, Roche Products Ltd.; N. Ruperto, MD, MPH, Istituto Giannina Gaslini, Pediatria II, Rheumatologia, PRINTO Coordinating Centre; F. De Benedetti, MD, PhD, IRCCS Ospedale Pediatrico Bambino Gesù. Address correspondence to Dr. F. De Benedetti, IRCCS Ospedale Pediatrico Bambino Gesù, Piazza S. Onofrio 4, 00165 Rome, Italy. E-mail: fabrizio.debenedetti@opbg.net. Full Release Article. For details see Reprints and Permissions at jrheum.org. Accepted for publication February 16, 2018.
Fabrizio De Benedetti
From Genentech, San Francisco; Consultant, Santa Monica, California, USA; Division of Rheumatology, Department of Pediatrics, University of Cincinnati, Cincinnati Children’s Hospital Medical Center (CCHMC), Pediatric Rheumatology Collaborative Study Group (PRCSG) Coordinating Center, Cincinnati, Ohio, USA; Paediatric Rheumatology Department, Hospital Universitario La Fe, Valencia, Spain; Pediatric Department, V.A. Nasonova Research Institute of Rheumatology; Department of Pediatric Rheumatology, Hospital of Childhood Diseases, JCA-UNIT, Sechenov Moscow Medical Academy, Moscow, Russia; Department of Pediatrics, Hospital Universitario Dr. J.E. González, Universidad Autónoma de Nuevo, Monterrey, Mexico; Universidade Federal do Rio de Janeiro, Instituto de Puericultura e Pediatria Martagao Gesteira (IPPMG); Hospital Universitario Pedro Ernesto, Nucleo de Estudos da Saúde do Adolescente, Universidade do Estado do Rio de Janeiro, Rio de Janeiro, Brazil; Wojewodzki Szpital Dzieciecy, Oddzial Pediatrii, Hematologii Onkologii i Reumatologii, Bydgoszcz, Poland; Department of Pediatrics, Alberta Children’s Hospital and University of Calgary, Calgary, Alberta, Canada; Klinikum Bremen-Mitte, Professor Hess-Kinderklinik, Pädiatrische Intensivmedizin, Bremen, Germany; Rheumatology Unit, Department of Woman and Child Health, University of Padua, Padua; Istituto Giannina Gaslini, Pediatria II, Rheumatologia, Paediatric Rheumatology International Trials Organisation (PRINTO) Coordinating Centre, Genoa; Institute for Research and Health Care (IRCCS) Ospedale Pediatrico Bambino Gesù, Rome, Italy; Royal Children’s Hospital, Pediatric Rheumatology, Melbourne, Victoria; Department of Rheumatology, Sydney Children’s Hospital Network, Randwick and Westmead, Sydney, Australia; Roche Products Ltd., Welwyn Garden City, UK. The study was funded by F. Hoffmann-La Roche Ltd. Writing and editorial services were provided by ApotheCom and funded by F. Hoffmann-La Roche Ltd. K.N. Bharucha is an employee of Genentech. H.I. Brunner reports funding from F. Hoffmann-La Roche Ltd. She is employed by CCHMC, which served as the North American PRCSG Coordinating Center. She is on the speaker’s bureau of Genentech and serves as a consultant. I. Nikishina reports other funding from F. Hoffmann-La Roche Ltd. K. Kobusinska reports other funding from F. Hoffmann-La Roche Ltd. H. Schmeling reports grants from F. Hoffmann-La Roche Ltd., Janssen, Pfizer, and UCB Biosciences GmbH. J. Frane was a consultant for Genentech and has been employed as a consultant or an employee of Roche/Genentech. C. Wells is an employee of and owns shares in Roche. F. De Benedetti reports grants from Novartis, Roche, Pfizer, and Sanofi. K.N. Bharucha, PhD, MD, Genentech; H.I. Brunner, MD, MSc, Division of Rheumatology, Department of Pediatrics, University of Cincinnati, CCHMC, PRCSG Coordinating Center; I. Calvo Penadés, MD, PhD, Paediatric Rheumatology Department, Hospital Universitario La Fe; I. Nikishina, MD, PhD, Pediatric Department, V.A. Nasonova Research Institute of Rheumatology; N. Rubio-Pérez, MD, Department of Pediatrics, Hospital Universitario Dr. J.E. González, Universidad Autónoma de Nuevo; S. Oliveira, MD, Universidade Federal do Rio de Janeiro, IPPMG; K. Kobusinska, MD, Wojewodzki Szpital Dzieciecy, Oddzial Pediatrii, Hematologii Onkologii i Reumatologii; H. Schmeling, MD, Department of Pediatrics, Alberta Children’s Hospital and University of Calgary; F. Sztajnbok, MD, Hospital Universitario Pedro Ernesto, Nucleo de Estudos da Saúde do Adolescente, Universidade do Estado do Rio de Janeiro; F. Weller-Heinemann, MD, Klinikum Bremen-Mitte, Professor Hess-Kinderklinik, Pädiatrische Intensivmedizin; E. Zholobova, MD, Department of Pediatric Rheumatology, Hospital of Childhood Diseases, JCA-UNIT, Sechenov Moscow Medical Academy; F. Zulian, MD, Rheumatology Unit, Department of Woman and Child Health, University of Padua; R. Allen, MD, Royal Children’s Hospital, Pediatric Rheumatology; J. Chaitow, MD, Department of Rheumatology, Sydney Children’s Hospital Network; J. Frane, PhD, Consultant; C. Wells, Roche Products Ltd.; N. Ruperto, MD, MPH, Istituto Giannina Gaslini, Pediatria II, Rheumatologia, PRINTO Coordinating Centre; F. De Benedetti, MD, PhD, IRCCS Ospedale Pediatrico Bambino Gesù. Address correspondence to Dr. F. De Benedetti, IRCCS Ospedale Pediatrico Bambino Gesù, Piazza S. Onofrio 4, 00165 Rome, Italy. E-mail: fabrizio.debenedetti@opbg.net. Full Release Article. For details see Reprints and Permissions at jrheum.org. Accepted for publication February 16, 2018.
From Genentech, San Francisco; Consultant, Santa Monica, California, USA; Division of Rheumatology, Department of Pediatrics, University of Cincinnati, Cincinnati Children’s Hospital Medical Center (CCHMC), Pediatric Rheumatology Collaborative Study Group (PRCSG) Coordinating Center, Cincinnati, Ohio, USA; Paediatric Rheumatology Department, Hospital Universitario La Fe, Valencia, Spain; Pediatric Department, V.A. Nasonova Research Institute of Rheumatology; Department of Pediatric Rheumatology, Hospital of Childhood Diseases, JCA-UNIT, Sechenov Moscow Medical Academy, Moscow, Russia; Department of Pediatrics, Hospital Universitario Dr. J.E. González, Universidad Autónoma de Nuevo, Monterrey, Mexico; Universidade Federal do Rio de Janeiro, Instituto de Puericultura e Pediatria Martagao Gesteira (IPPMG); Hospital Universitario Pedro Ernesto, Nucleo de Estudos da Saúde do Adolescente, Universidade do Estado do Rio de Janeiro, Rio de Janeiro, Brazil; Wojewodzki Szpital Dzieciecy, Oddzial Pediatrii, Hematologii Onkologii i Reumatologii, Bydgoszcz, Poland; Department of Pediatrics, Alberta Children’s Hospital and University of Calgary, Calgary, Alberta, Canada; Klinikum Bremen-Mitte, Professor Hess-Kinderklinik, Pädiatrische Intensivmedizin, Bremen, Germany; Rheumatology Unit, Department of Woman and Child Health, University of Padua, Padua; Istituto Giannina Gaslini, Pediatria II, Rheumatologia, Paediatric Rheumatology International Trials Organisation (PRINTO) Coordinating Centre, Genoa; Institute for Research and Health Care (IRCCS) Ospedale Pediatrico Bambino Gesù, Rome, Italy; Royal Children’s Hospital, Pediatric Rheumatology, Melbourne, Victoria; Department of Rheumatology, Sydney Children’s Hospital Network, Randwick and Westmead, Sydney, Australia; Roche Products Ltd., Welwyn Garden City, UK. The study was funded by F. Hoffmann-La Roche Ltd. Writing and editorial services were provided by ApotheCom and funded by F. Hoffmann-La Roche Ltd. K.N. Bharucha is an employee of Genentech. H.I. Brunner reports funding from F. Hoffmann-La Roche Ltd. She is employed by CCHMC, which served as the North American PRCSG Coordinating Center. She is on the speaker’s bureau of Genentech and serves as a consultant. I. Nikishina reports other funding from F. Hoffmann-La Roche Ltd. K. Kobusinska reports other funding from F. Hoffmann-La Roche Ltd. H. Schmeling reports grants from F. Hoffmann-La Roche Ltd., Janssen, Pfizer, and UCB Biosciences GmbH. J. Frane was a consultant for Genentech and has been employed as a consultant or an employee of Roche/Genentech. C. Wells is an employee of and owns shares in Roche. F. De Benedetti reports grants from Novartis, Roche, Pfizer, and Sanofi. K.N. Bharucha, PhD, MD, Genentech; H.I. Brunner, MD, MSc, Division of Rheumatology, Department of Pediatrics, University of Cincinnati, CCHMC, PRCSG Coordinating Center; I. Calvo Penadés, MD, PhD, Paediatric Rheumatology Department, Hospital Universitario La Fe; I. Nikishina, MD, PhD, Pediatric Department, V.A. Nasonova Research Institute of Rheumatology; N. Rubio-Pérez, MD, Department of Pediatrics, Hospital Universitario Dr. J.E. González, Universidad Autónoma de Nuevo; S. Oliveira, MD, Universidade Federal do Rio de Janeiro, IPPMG; K. Kobusinska, MD, Wojewodzki Szpital Dzieciecy, Oddzial Pediatrii, Hematologii Onkologii i Reumatologii; H. Schmeling, MD, Department of Pediatrics, Alberta Children’s Hospital and University of Calgary; F. Sztajnbok, MD, Hospital Universitario Pedro Ernesto, Nucleo de Estudos da Saúde do Adolescente, Universidade do Estado do Rio de Janeiro; F. Weller-Heinemann, MD, Klinikum Bremen-Mitte, Professor Hess-Kinderklinik, Pädiatrische Intensivmedizin; E. Zholobova, MD, Department of Pediatric Rheumatology, Hospital of Childhood Diseases, JCA-UNIT, Sechenov Moscow Medical Academy; F. Zulian, MD, Rheumatology Unit, Department of Woman and Child Health, University of Padua; R. Allen, MD, Royal Children’s Hospital, Pediatric Rheumatology; J. Chaitow, MD, Department of Rheumatology, Sydney Children’s Hospital Network; J. Frane, PhD, Consultant; C. Wells, Roche Products Ltd.; N. Ruperto, MD, MPH, Istituto Giannina Gaslini, Pediatria II, Rheumatologia, PRINTO Coordinating Centre; F. De Benedetti, MD, PhD, IRCCS Ospedale Pediatrico Bambino Gesù. Address correspondence to Dr. F. De Benedetti, IRCCS Ospedale Pediatrico Bambino Gesù, Piazza S. Onofrio 4, 00165 Rome, Italy. E-mail: fabrizio.debenedetti@opbg.net. Full Release Article. For details see Reprints and Permissions at jrheum.org. Accepted for publication February 16, 2018.
In this issue
The Journal of Rheumatology
Vol. 51, Issue 4
1 Apr 2024
Growth During Tocilizumab Therapy for Polyarticular-course Juvenile Idiopathic Arthritis: 2-year Data from a Phase III Clinical Trial
Kamal N. Bharucha, Hermine I. Brunner, Inmaculada Calvo Penadés, Irina Nikishina, Nadina Rubio-Pérez, Sheila Oliveira, Katarzyna Kobusinska, Heinrike Schmeling, Flavio Sztajnbok, Frank Weller-Heinemann, Elena Zholobova, Francesco Zulian, Roger Allen, Jeffrey Chaitow, James Frane, Chris Wells, Nicolino Ruperto, Fabrizio De Benedetti, for the Paediatric Rheumatology International Trials Organisation and the Pediatric Rheumatology Collaborative Study Group
The Journal of Rheumatology Jul 2018, jrheum.170326; DOI: 10.3899/jrheum.170326
Growth During Tocilizumab Therapy for Polyarticular-course Juvenile Idiopathic Arthritis: 2-year Data from a Phase III Clinical Trial
Kamal N. Bharucha, Hermine I. Brunner, Inmaculada Calvo Penadés, Irina Nikishina, Nadina Rubio-Pérez, Sheila Oliveira, Katarzyna Kobusinska, Heinrike Schmeling, Flavio Sztajnbok, Frank Weller-Heinemann, Elena Zholobova, Francesco Zulian, Roger Allen, Jeffrey Chaitow, James Frane, Chris Wells, Nicolino Ruperto, Fabrizio De Benedetti, for the Paediatric Rheumatology International Trials Organisation and the Pediatric Rheumatology Collaborative Study Group
The Journal of Rheumatology Jul 2018, jrheum.170326; DOI: 10.3899/jrheum.170326