Research ArticleArticle
HLA-DRB1 Shared Epitope Alleles and Disease Activity Are Correlated with Reduced T Cell Receptor Repertoire Diversity in CD4+ T Cells in Rheumatoid Arthritis
Keiichi Sakurai, Kazuyoshi Ishigaki, Hirofumi Shoda, Yasuo Nagafuchi, Yumi Tsuchida, Shuji Sumitomo, Hiroko Kanda, Akari Suzuki, Yuta Kochi, Kazuhiko Yamamoto and Keishi Fujio
The Journal of Rheumatology April 2018, jrheum.170909; DOI: https://doi.org/10.3899/jrheum.170909
Keiichi Sakurai
From the Department of Allergy and Rheumatology, Graduate School of Medicine, The University of Tokyo, Tokyo; Laboratory for Autoimmune Diseases, RIKEN Center for Integrative Medical Sciences, Yokohama City, Kanagawa, Japan. Supported by the Ministry of Health, Labor, and Welfare, the Ministry of Education, Culture, Sports, Science, and Technology (KAKENHI) Grantin- Aid for Scientific Research (C, 26461462), as well as by a Grant-in-Aid for Scientific Research (S, 23229007) from the Japan Society for the Promotion of Science. K.Y. received financial support or fees from Astellas, BMS, MitsubishiTanabe, Pfizer, Ayumi, Takeda, Chugai, Eisai, Taisho Toyama, UCB, and ImmunoFuture. K.F. received financial support or fees from Astellas, BMS, MitsubishiTanabe, Pfizer, Ayumi, Takeda, Chugai, Eisai, Taisho Toyama, Eli Lilly, and UCB. K. Sakurai, MD, PhD, Department of Allergy and Rheumatology, Graduate School of Medicine, The University of Tokyo; K. Ishigaki, MD, PhD, Laboratory for Autoimmune Diseases, RIKEN Center for Integrative Medical Sciences; H. Shoda, MD, PhD, Department of Allergy and Rheumatology, Graduate School of Medicine, The University of Tokyo; Y. Nagafuchi, MD, PhD, Department of Allergy and Rheumatology, Graduate School of Medicine, The University of Tokyo; Y. Tsuchida, MD, PhD, Department of Allergy and Rheumatology, Graduate School of Medicine, The University of Tokyo; S. Sumitomo, MD, PhD, Department of Allergy and Rheumatology, Graduate School of Medicine, The University of Tokyo; H. Kanda, MD, PhD, Department of Allergy and Rheumatology, Graduate School of Medicine, The University of Tokyo; A. Suzuki, PhD, Laboratory for Autoimmune Diseases, RIKEN Center for Integrative Medical Sciences; Y. Kochi, MD, PhD, Laboratory for Autoimmune Diseases, RIKEN Center for Integrative Medical Sciences; K. Yamamoto, MD, PhD, Department of Allergy and Rheumatology, Graduate School of Medicine, The University of Tokyo, and Laboratory for Autoimmune Diseases, RIKEN Center for Integrative Medical Sciences; K. Fujio, MD, PhD, Department of Allergy and Rheumatology, Graduate School of Medicine, The University of Tokyo. Address correspondence to Dr. K. Fujio, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-0033, Japan. E-mail: kfujio-tky@umin.ac.jp. Accepted for publication January 24, 2018.
Kazuyoshi Ishigaki
From the Department of Allergy and Rheumatology, Graduate School of Medicine, The University of Tokyo, Tokyo; Laboratory for Autoimmune Diseases, RIKEN Center for Integrative Medical Sciences, Yokohama City, Kanagawa, Japan. Supported by the Ministry of Health, Labor, and Welfare, the Ministry of Education, Culture, Sports, Science, and Technology (KAKENHI) Grantin- Aid for Scientific Research (C, 26461462), as well as by a Grant-in-Aid for Scientific Research (S, 23229007) from the Japan Society for the Promotion of Science. K.Y. received financial support or fees from Astellas, BMS, MitsubishiTanabe, Pfizer, Ayumi, Takeda, Chugai, Eisai, Taisho Toyama, UCB, and ImmunoFuture. K.F. received financial support or fees from Astellas, BMS, MitsubishiTanabe, Pfizer, Ayumi, Takeda, Chugai, Eisai, Taisho Toyama, Eli Lilly, and UCB. K. Sakurai, MD, PhD, Department of Allergy and Rheumatology, Graduate School of Medicine, The University of Tokyo; K. Ishigaki, MD, PhD, Laboratory for Autoimmune Diseases, RIKEN Center for Integrative Medical Sciences; H. Shoda, MD, PhD, Department of Allergy and Rheumatology, Graduate School of Medicine, The University of Tokyo; Y. Nagafuchi, MD, PhD, Department of Allergy and Rheumatology, Graduate School of Medicine, The University of Tokyo; Y. Tsuchida, MD, PhD, Department of Allergy and Rheumatology, Graduate School of Medicine, The University of Tokyo; S. Sumitomo, MD, PhD, Department of Allergy and Rheumatology, Graduate School of Medicine, The University of Tokyo; H. Kanda, MD, PhD, Department of Allergy and Rheumatology, Graduate School of Medicine, The University of Tokyo; A. Suzuki, PhD, Laboratory for Autoimmune Diseases, RIKEN Center for Integrative Medical Sciences; Y. Kochi, MD, PhD, Laboratory for Autoimmune Diseases, RIKEN Center for Integrative Medical Sciences; K. Yamamoto, MD, PhD, Department of Allergy and Rheumatology, Graduate School of Medicine, The University of Tokyo, and Laboratory for Autoimmune Diseases, RIKEN Center for Integrative Medical Sciences; K. Fujio, MD, PhD, Department of Allergy and Rheumatology, Graduate School of Medicine, The University of Tokyo. Address correspondence to Dr. K. Fujio, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-0033, Japan. E-mail: kfujio-tky@umin.ac.jp. Accepted for publication January 24, 2018.
Hirofumi Shoda
From the Department of Allergy and Rheumatology, Graduate School of Medicine, The University of Tokyo, Tokyo; Laboratory for Autoimmune Diseases, RIKEN Center for Integrative Medical Sciences, Yokohama City, Kanagawa, Japan. Supported by the Ministry of Health, Labor, and Welfare, the Ministry of Education, Culture, Sports, Science, and Technology (KAKENHI) Grantin- Aid for Scientific Research (C, 26461462), as well as by a Grant-in-Aid for Scientific Research (S, 23229007) from the Japan Society for the Promotion of Science. K.Y. received financial support or fees from Astellas, BMS, MitsubishiTanabe, Pfizer, Ayumi, Takeda, Chugai, Eisai, Taisho Toyama, UCB, and ImmunoFuture. K.F. received financial support or fees from Astellas, BMS, MitsubishiTanabe, Pfizer, Ayumi, Takeda, Chugai, Eisai, Taisho Toyama, Eli Lilly, and UCB. K. Sakurai, MD, PhD, Department of Allergy and Rheumatology, Graduate School of Medicine, The University of Tokyo; K. Ishigaki, MD, PhD, Laboratory for Autoimmune Diseases, RIKEN Center for Integrative Medical Sciences; H. Shoda, MD, PhD, Department of Allergy and Rheumatology, Graduate School of Medicine, The University of Tokyo; Y. Nagafuchi, MD, PhD, Department of Allergy and Rheumatology, Graduate School of Medicine, The University of Tokyo; Y. Tsuchida, MD, PhD, Department of Allergy and Rheumatology, Graduate School of Medicine, The University of Tokyo; S. Sumitomo, MD, PhD, Department of Allergy and Rheumatology, Graduate School of Medicine, The University of Tokyo; H. Kanda, MD, PhD, Department of Allergy and Rheumatology, Graduate School of Medicine, The University of Tokyo; A. Suzuki, PhD, Laboratory for Autoimmune Diseases, RIKEN Center for Integrative Medical Sciences; Y. Kochi, MD, PhD, Laboratory for Autoimmune Diseases, RIKEN Center for Integrative Medical Sciences; K. Yamamoto, MD, PhD, Department of Allergy and Rheumatology, Graduate School of Medicine, The University of Tokyo, and Laboratory for Autoimmune Diseases, RIKEN Center for Integrative Medical Sciences; K. Fujio, MD, PhD, Department of Allergy and Rheumatology, Graduate School of Medicine, The University of Tokyo. Address correspondence to Dr. K. Fujio, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-0033, Japan. E-mail: kfujio-tky@umin.ac.jp. Accepted for publication January 24, 2018.
Yasuo Nagafuchi
From the Department of Allergy and Rheumatology, Graduate School of Medicine, The University of Tokyo, Tokyo; Laboratory for Autoimmune Diseases, RIKEN Center for Integrative Medical Sciences, Yokohama City, Kanagawa, Japan. Supported by the Ministry of Health, Labor, and Welfare, the Ministry of Education, Culture, Sports, Science, and Technology (KAKENHI) Grantin- Aid for Scientific Research (C, 26461462), as well as by a Grant-in-Aid for Scientific Research (S, 23229007) from the Japan Society for the Promotion of Science. K.Y. received financial support or fees from Astellas, BMS, MitsubishiTanabe, Pfizer, Ayumi, Takeda, Chugai, Eisai, Taisho Toyama, UCB, and ImmunoFuture. K.F. received financial support or fees from Astellas, BMS, MitsubishiTanabe, Pfizer, Ayumi, Takeda, Chugai, Eisai, Taisho Toyama, Eli Lilly, and UCB. K. Sakurai, MD, PhD, Department of Allergy and Rheumatology, Graduate School of Medicine, The University of Tokyo; K. Ishigaki, MD, PhD, Laboratory for Autoimmune Diseases, RIKEN Center for Integrative Medical Sciences; H. Shoda, MD, PhD, Department of Allergy and Rheumatology, Graduate School of Medicine, The University of Tokyo; Y. Nagafuchi, MD, PhD, Department of Allergy and Rheumatology, Graduate School of Medicine, The University of Tokyo; Y. Tsuchida, MD, PhD, Department of Allergy and Rheumatology, Graduate School of Medicine, The University of Tokyo; S. Sumitomo, MD, PhD, Department of Allergy and Rheumatology, Graduate School of Medicine, The University of Tokyo; H. Kanda, MD, PhD, Department of Allergy and Rheumatology, Graduate School of Medicine, The University of Tokyo; A. Suzuki, PhD, Laboratory for Autoimmune Diseases, RIKEN Center for Integrative Medical Sciences; Y. Kochi, MD, PhD, Laboratory for Autoimmune Diseases, RIKEN Center for Integrative Medical Sciences; K. Yamamoto, MD, PhD, Department of Allergy and Rheumatology, Graduate School of Medicine, The University of Tokyo, and Laboratory for Autoimmune Diseases, RIKEN Center for Integrative Medical Sciences; K. Fujio, MD, PhD, Department of Allergy and Rheumatology, Graduate School of Medicine, The University of Tokyo. Address correspondence to Dr. K. Fujio, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-0033, Japan. E-mail: kfujio-tky@umin.ac.jp. Accepted for publication January 24, 2018.
Yumi Tsuchida
From the Department of Allergy and Rheumatology, Graduate School of Medicine, The University of Tokyo, Tokyo; Laboratory for Autoimmune Diseases, RIKEN Center for Integrative Medical Sciences, Yokohama City, Kanagawa, Japan. Supported by the Ministry of Health, Labor, and Welfare, the Ministry of Education, Culture, Sports, Science, and Technology (KAKENHI) Grantin- Aid for Scientific Research (C, 26461462), as well as by a Grant-in-Aid for Scientific Research (S, 23229007) from the Japan Society for the Promotion of Science. K.Y. received financial support or fees from Astellas, BMS, MitsubishiTanabe, Pfizer, Ayumi, Takeda, Chugai, Eisai, Taisho Toyama, UCB, and ImmunoFuture. K.F. received financial support or fees from Astellas, BMS, MitsubishiTanabe, Pfizer, Ayumi, Takeda, Chugai, Eisai, Taisho Toyama, Eli Lilly, and UCB. K. Sakurai, MD, PhD, Department of Allergy and Rheumatology, Graduate School of Medicine, The University of Tokyo; K. Ishigaki, MD, PhD, Laboratory for Autoimmune Diseases, RIKEN Center for Integrative Medical Sciences; H. Shoda, MD, PhD, Department of Allergy and Rheumatology, Graduate School of Medicine, The University of Tokyo; Y. Nagafuchi, MD, PhD, Department of Allergy and Rheumatology, Graduate School of Medicine, The University of Tokyo; Y. Tsuchida, MD, PhD, Department of Allergy and Rheumatology, Graduate School of Medicine, The University of Tokyo; S. Sumitomo, MD, PhD, Department of Allergy and Rheumatology, Graduate School of Medicine, The University of Tokyo; H. Kanda, MD, PhD, Department of Allergy and Rheumatology, Graduate School of Medicine, The University of Tokyo; A. Suzuki, PhD, Laboratory for Autoimmune Diseases, RIKEN Center for Integrative Medical Sciences; Y. Kochi, MD, PhD, Laboratory for Autoimmune Diseases, RIKEN Center for Integrative Medical Sciences; K. Yamamoto, MD, PhD, Department of Allergy and Rheumatology, Graduate School of Medicine, The University of Tokyo, and Laboratory for Autoimmune Diseases, RIKEN Center for Integrative Medical Sciences; K. Fujio, MD, PhD, Department of Allergy and Rheumatology, Graduate School of Medicine, The University of Tokyo. Address correspondence to Dr. K. Fujio, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-0033, Japan. E-mail: kfujio-tky@umin.ac.jp. Accepted for publication January 24, 2018.
Shuji Sumitomo
From the Department of Allergy and Rheumatology, Graduate School of Medicine, The University of Tokyo, Tokyo; Laboratory for Autoimmune Diseases, RIKEN Center for Integrative Medical Sciences, Yokohama City, Kanagawa, Japan. Supported by the Ministry of Health, Labor, and Welfare, the Ministry of Education, Culture, Sports, Science, and Technology (KAKENHI) Grantin- Aid for Scientific Research (C, 26461462), as well as by a Grant-in-Aid for Scientific Research (S, 23229007) from the Japan Society for the Promotion of Science. K.Y. received financial support or fees from Astellas, BMS, MitsubishiTanabe, Pfizer, Ayumi, Takeda, Chugai, Eisai, Taisho Toyama, UCB, and ImmunoFuture. K.F. received financial support or fees from Astellas, BMS, MitsubishiTanabe, Pfizer, Ayumi, Takeda, Chugai, Eisai, Taisho Toyama, Eli Lilly, and UCB. K. Sakurai, MD, PhD, Department of Allergy and Rheumatology, Graduate School of Medicine, The University of Tokyo; K. Ishigaki, MD, PhD, Laboratory for Autoimmune Diseases, RIKEN Center for Integrative Medical Sciences; H. Shoda, MD, PhD, Department of Allergy and Rheumatology, Graduate School of Medicine, The University of Tokyo; Y. Nagafuchi, MD, PhD, Department of Allergy and Rheumatology, Graduate School of Medicine, The University of Tokyo; Y. Tsuchida, MD, PhD, Department of Allergy and Rheumatology, Graduate School of Medicine, The University of Tokyo; S. Sumitomo, MD, PhD, Department of Allergy and Rheumatology, Graduate School of Medicine, The University of Tokyo; H. Kanda, MD, PhD, Department of Allergy and Rheumatology, Graduate School of Medicine, The University of Tokyo; A. Suzuki, PhD, Laboratory for Autoimmune Diseases, RIKEN Center for Integrative Medical Sciences; Y. Kochi, MD, PhD, Laboratory for Autoimmune Diseases, RIKEN Center for Integrative Medical Sciences; K. Yamamoto, MD, PhD, Department of Allergy and Rheumatology, Graduate School of Medicine, The University of Tokyo, and Laboratory for Autoimmune Diseases, RIKEN Center for Integrative Medical Sciences; K. Fujio, MD, PhD, Department of Allergy and Rheumatology, Graduate School of Medicine, The University of Tokyo. Address correspondence to Dr. K. Fujio, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-0033, Japan. E-mail: kfujio-tky@umin.ac.jp. Accepted for publication January 24, 2018.
Hiroko Kanda
From the Department of Allergy and Rheumatology, Graduate School of Medicine, The University of Tokyo, Tokyo; Laboratory for Autoimmune Diseases, RIKEN Center for Integrative Medical Sciences, Yokohama City, Kanagawa, Japan. Supported by the Ministry of Health, Labor, and Welfare, the Ministry of Education, Culture, Sports, Science, and Technology (KAKENHI) Grantin- Aid for Scientific Research (C, 26461462), as well as by a Grant-in-Aid for Scientific Research (S, 23229007) from the Japan Society for the Promotion of Science. K.Y. received financial support or fees from Astellas, BMS, MitsubishiTanabe, Pfizer, Ayumi, Takeda, Chugai, Eisai, Taisho Toyama, UCB, and ImmunoFuture. K.F. received financial support or fees from Astellas, BMS, MitsubishiTanabe, Pfizer, Ayumi, Takeda, Chugai, Eisai, Taisho Toyama, Eli Lilly, and UCB. K. Sakurai, MD, PhD, Department of Allergy and Rheumatology, Graduate School of Medicine, The University of Tokyo; K. Ishigaki, MD, PhD, Laboratory for Autoimmune Diseases, RIKEN Center for Integrative Medical Sciences; H. Shoda, MD, PhD, Department of Allergy and Rheumatology, Graduate School of Medicine, The University of Tokyo; Y. Nagafuchi, MD, PhD, Department of Allergy and Rheumatology, Graduate School of Medicine, The University of Tokyo; Y. Tsuchida, MD, PhD, Department of Allergy and Rheumatology, Graduate School of Medicine, The University of Tokyo; S. Sumitomo, MD, PhD, Department of Allergy and Rheumatology, Graduate School of Medicine, The University of Tokyo; H. Kanda, MD, PhD, Department of Allergy and Rheumatology, Graduate School of Medicine, The University of Tokyo; A. Suzuki, PhD, Laboratory for Autoimmune Diseases, RIKEN Center for Integrative Medical Sciences; Y. Kochi, MD, PhD, Laboratory for Autoimmune Diseases, RIKEN Center for Integrative Medical Sciences; K. Yamamoto, MD, PhD, Department of Allergy and Rheumatology, Graduate School of Medicine, The University of Tokyo, and Laboratory for Autoimmune Diseases, RIKEN Center for Integrative Medical Sciences; K. Fujio, MD, PhD, Department of Allergy and Rheumatology, Graduate School of Medicine, The University of Tokyo. Address correspondence to Dr. K. Fujio, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-0033, Japan. E-mail: kfujio-tky@umin.ac.jp. Accepted for publication January 24, 2018.
Akari Suzuki
From the Department of Allergy and Rheumatology, Graduate School of Medicine, The University of Tokyo, Tokyo; Laboratory for Autoimmune Diseases, RIKEN Center for Integrative Medical Sciences, Yokohama City, Kanagawa, Japan. Supported by the Ministry of Health, Labor, and Welfare, the Ministry of Education, Culture, Sports, Science, and Technology (KAKENHI) Grantin- Aid for Scientific Research (C, 26461462), as well as by a Grant-in-Aid for Scientific Research (S, 23229007) from the Japan Society for the Promotion of Science. K.Y. received financial support or fees from Astellas, BMS, MitsubishiTanabe, Pfizer, Ayumi, Takeda, Chugai, Eisai, Taisho Toyama, UCB, and ImmunoFuture. K.F. received financial support or fees from Astellas, BMS, MitsubishiTanabe, Pfizer, Ayumi, Takeda, Chugai, Eisai, Taisho Toyama, Eli Lilly, and UCB. K. Sakurai, MD, PhD, Department of Allergy and Rheumatology, Graduate School of Medicine, The University of Tokyo; K. Ishigaki, MD, PhD, Laboratory for Autoimmune Diseases, RIKEN Center for Integrative Medical Sciences; H. Shoda, MD, PhD, Department of Allergy and Rheumatology, Graduate School of Medicine, The University of Tokyo; Y. Nagafuchi, MD, PhD, Department of Allergy and Rheumatology, Graduate School of Medicine, The University of Tokyo; Y. Tsuchida, MD, PhD, Department of Allergy and Rheumatology, Graduate School of Medicine, The University of Tokyo; S. Sumitomo, MD, PhD, Department of Allergy and Rheumatology, Graduate School of Medicine, The University of Tokyo; H. Kanda, MD, PhD, Department of Allergy and Rheumatology, Graduate School of Medicine, The University of Tokyo; A. Suzuki, PhD, Laboratory for Autoimmune Diseases, RIKEN Center for Integrative Medical Sciences; Y. Kochi, MD, PhD, Laboratory for Autoimmune Diseases, RIKEN Center for Integrative Medical Sciences; K. Yamamoto, MD, PhD, Department of Allergy and Rheumatology, Graduate School of Medicine, The University of Tokyo, and Laboratory for Autoimmune Diseases, RIKEN Center for Integrative Medical Sciences; K. Fujio, MD, PhD, Department of Allergy and Rheumatology, Graduate School of Medicine, The University of Tokyo. Address correspondence to Dr. K. Fujio, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-0033, Japan. E-mail: kfujio-tky@umin.ac.jp. Accepted for publication January 24, 2018.
Yuta Kochi
From the Department of Allergy and Rheumatology, Graduate School of Medicine, The University of Tokyo, Tokyo; Laboratory for Autoimmune Diseases, RIKEN Center for Integrative Medical Sciences, Yokohama City, Kanagawa, Japan. Supported by the Ministry of Health, Labor, and Welfare, the Ministry of Education, Culture, Sports, Science, and Technology (KAKENHI) Grantin- Aid for Scientific Research (C, 26461462), as well as by a Grant-in-Aid for Scientific Research (S, 23229007) from the Japan Society for the Promotion of Science. K.Y. received financial support or fees from Astellas, BMS, MitsubishiTanabe, Pfizer, Ayumi, Takeda, Chugai, Eisai, Taisho Toyama, UCB, and ImmunoFuture. K.F. received financial support or fees from Astellas, BMS, MitsubishiTanabe, Pfizer, Ayumi, Takeda, Chugai, Eisai, Taisho Toyama, Eli Lilly, and UCB. K. Sakurai, MD, PhD, Department of Allergy and Rheumatology, Graduate School of Medicine, The University of Tokyo; K. Ishigaki, MD, PhD, Laboratory for Autoimmune Diseases, RIKEN Center for Integrative Medical Sciences; H. Shoda, MD, PhD, Department of Allergy and Rheumatology, Graduate School of Medicine, The University of Tokyo; Y. Nagafuchi, MD, PhD, Department of Allergy and Rheumatology, Graduate School of Medicine, The University of Tokyo; Y. Tsuchida, MD, PhD, Department of Allergy and Rheumatology, Graduate School of Medicine, The University of Tokyo; S. Sumitomo, MD, PhD, Department of Allergy and Rheumatology, Graduate School of Medicine, The University of Tokyo; H. Kanda, MD, PhD, Department of Allergy and Rheumatology, Graduate School of Medicine, The University of Tokyo; A. Suzuki, PhD, Laboratory for Autoimmune Diseases, RIKEN Center for Integrative Medical Sciences; Y. Kochi, MD, PhD, Laboratory for Autoimmune Diseases, RIKEN Center for Integrative Medical Sciences; K. Yamamoto, MD, PhD, Department of Allergy and Rheumatology, Graduate School of Medicine, The University of Tokyo, and Laboratory for Autoimmune Diseases, RIKEN Center for Integrative Medical Sciences; K. Fujio, MD, PhD, Department of Allergy and Rheumatology, Graduate School of Medicine, The University of Tokyo. Address correspondence to Dr. K. Fujio, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-0033, Japan. E-mail: kfujio-tky@umin.ac.jp. Accepted for publication January 24, 2018.
Kazuhiko Yamamoto
From the Department of Allergy and Rheumatology, Graduate School of Medicine, The University of Tokyo, Tokyo; Laboratory for Autoimmune Diseases, RIKEN Center for Integrative Medical Sciences, Yokohama City, Kanagawa, Japan. Supported by the Ministry of Health, Labor, and Welfare, the Ministry of Education, Culture, Sports, Science, and Technology (KAKENHI) Grantin- Aid for Scientific Research (C, 26461462), as well as by a Grant-in-Aid for Scientific Research (S, 23229007) from the Japan Society for the Promotion of Science. K.Y. received financial support or fees from Astellas, BMS, MitsubishiTanabe, Pfizer, Ayumi, Takeda, Chugai, Eisai, Taisho Toyama, UCB, and ImmunoFuture. K.F. received financial support or fees from Astellas, BMS, MitsubishiTanabe, Pfizer, Ayumi, Takeda, Chugai, Eisai, Taisho Toyama, Eli Lilly, and UCB. K. Sakurai, MD, PhD, Department of Allergy and Rheumatology, Graduate School of Medicine, The University of Tokyo; K. Ishigaki, MD, PhD, Laboratory for Autoimmune Diseases, RIKEN Center for Integrative Medical Sciences; H. Shoda, MD, PhD, Department of Allergy and Rheumatology, Graduate School of Medicine, The University of Tokyo; Y. Nagafuchi, MD, PhD, Department of Allergy and Rheumatology, Graduate School of Medicine, The University of Tokyo; Y. Tsuchida, MD, PhD, Department of Allergy and Rheumatology, Graduate School of Medicine, The University of Tokyo; S. Sumitomo, MD, PhD, Department of Allergy and Rheumatology, Graduate School of Medicine, The University of Tokyo; H. Kanda, MD, PhD, Department of Allergy and Rheumatology, Graduate School of Medicine, The University of Tokyo; A. Suzuki, PhD, Laboratory for Autoimmune Diseases, RIKEN Center for Integrative Medical Sciences; Y. Kochi, MD, PhD, Laboratory for Autoimmune Diseases, RIKEN Center for Integrative Medical Sciences; K. Yamamoto, MD, PhD, Department of Allergy and Rheumatology, Graduate School of Medicine, The University of Tokyo, and Laboratory for Autoimmune Diseases, RIKEN Center for Integrative Medical Sciences; K. Fujio, MD, PhD, Department of Allergy and Rheumatology, Graduate School of Medicine, The University of Tokyo. Address correspondence to Dr. K. Fujio, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-0033, Japan. E-mail: kfujio-tky@umin.ac.jp. Accepted for publication January 24, 2018.
Keishi Fujio
From the Department of Allergy and Rheumatology, Graduate School of Medicine, The University of Tokyo, Tokyo; Laboratory for Autoimmune Diseases, RIKEN Center for Integrative Medical Sciences, Yokohama City, Kanagawa, Japan. Supported by the Ministry of Health, Labor, and Welfare, the Ministry of Education, Culture, Sports, Science, and Technology (KAKENHI) Grantin- Aid for Scientific Research (C, 26461462), as well as by a Grant-in-Aid for Scientific Research (S, 23229007) from the Japan Society for the Promotion of Science. K.Y. received financial support or fees from Astellas, BMS, MitsubishiTanabe, Pfizer, Ayumi, Takeda, Chugai, Eisai, Taisho Toyama, UCB, and ImmunoFuture. K.F. received financial support or fees from Astellas, BMS, MitsubishiTanabe, Pfizer, Ayumi, Takeda, Chugai, Eisai, Taisho Toyama, Eli Lilly, and UCB. K. Sakurai, MD, PhD, Department of Allergy and Rheumatology, Graduate School of Medicine, The University of Tokyo; K. Ishigaki, MD, PhD, Laboratory for Autoimmune Diseases, RIKEN Center for Integrative Medical Sciences; H. Shoda, MD, PhD, Department of Allergy and Rheumatology, Graduate School of Medicine, The University of Tokyo; Y. Nagafuchi, MD, PhD, Department of Allergy and Rheumatology, Graduate School of Medicine, The University of Tokyo; Y. Tsuchida, MD, PhD, Department of Allergy and Rheumatology, Graduate School of Medicine, The University of Tokyo; S. Sumitomo, MD, PhD, Department of Allergy and Rheumatology, Graduate School of Medicine, The University of Tokyo; H. Kanda, MD, PhD, Department of Allergy and Rheumatology, Graduate School of Medicine, The University of Tokyo; A. Suzuki, PhD, Laboratory for Autoimmune Diseases, RIKEN Center for Integrative Medical Sciences; Y. Kochi, MD, PhD, Laboratory for Autoimmune Diseases, RIKEN Center for Integrative Medical Sciences; K. Yamamoto, MD, PhD, Department of Allergy and Rheumatology, Graduate School of Medicine, The University of Tokyo, and Laboratory for Autoimmune Diseases, RIKEN Center for Integrative Medical Sciences; K. Fujio, MD, PhD, Department of Allergy and Rheumatology, Graduate School of Medicine, The University of Tokyo. Address correspondence to Dr. K. Fujio, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-0033, Japan. E-mail: kfujio-tky@umin.ac.jp. Accepted for publication January 24, 2018.
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The Journal of Rheumatology
Vol. 51, Issue 4
1 Apr 2024
HLA-DRB1 Shared Epitope Alleles and Disease Activity Are Correlated with Reduced T Cell Receptor Repertoire Diversity in CD4+ T Cells in Rheumatoid Arthritis
Keiichi Sakurai, Kazuyoshi Ishigaki, Hirofumi Shoda, Yasuo Nagafuchi, Yumi Tsuchida, Shuji Sumitomo, Hiroko Kanda, Akari Suzuki, Yuta Kochi, Kazuhiko Yamamoto, Keishi Fujio
The Journal of Rheumatology Apr 2018, jrheum.170909; DOI: 10.3899/jrheum.170909
HLA-DRB1 Shared Epitope Alleles and Disease Activity Are Correlated with Reduced T Cell Receptor Repertoire Diversity in CD4+ T Cells in Rheumatoid Arthritis
Keiichi Sakurai, Kazuyoshi Ishigaki, Hirofumi Shoda, Yasuo Nagafuchi, Yumi Tsuchida, Shuji Sumitomo, Hiroko Kanda, Akari Suzuki, Yuta Kochi, Kazuhiko Yamamoto, Keishi Fujio
The Journal of Rheumatology Apr 2018, jrheum.170909; DOI: 10.3899/jrheum.170909