Research ArticleArticle
Longterm Safety and Efficacy of Subcutaneous Abatacept in Patients with Rheumatoid Arthritis: 5-year Results from a Phase IIIb Trial
Mark C. Genovese, César Pacheco-Tena, Arturo Covarrubias, Gustavo Leon, Eduardo Mysler, Mauro Keiserman, Robert M. Valente, Peter Nash, J. Abraham Simon-Campos, Jane Box, Clarence W. Legerton III, Evgeny Nasonov, Patrick Durez, Ayanbola Elegbe, Robert Wong, Xiaohui Li, Subhashis Banerjee and Rieke Alten
The Journal of Rheumatology April 2018, jrheum.170344; DOI: https://doi.org/10.3899/jrheum.170344
Mark C. Genovese
From Stanford University, Palo Alto, California; Arthritis Center of Nebraska, Lincoln, Nebraska; Box Arthritis and Rheumatology of the Carolinas, Charlotte, North Carolina; Low Country Rheumatology, Charleston, South Carolina; Bristol-Myers Squibb, Princeton, New Jersey, USA; Universidad Autónoma de Chihuahua, Chihuahua; Unidad Reumatológica Las Américas S.C.P., Mérida; Köhler & Milstein Research, Mérida, Mexico; Instituto De Ginecología Y Reproducción, Lima, Peru; Organización Médica de Investigación, Buenos Aires, Argentina; Pontifical Catholic University, Porto Alegre, Brazil; University of Queensland, Brisbane, Australia; Russian Academy of Medical Sciences, Moscow, Russia; Cliniques Universitaires Saint-Luc; Université Catholique de Louvain, Brussels, Belgium; Schlosspark-Klinik University Medicine, Berlin, Germany. This study was sponsored by Bristol-Myers Squibb. Dr. R.M. Valente received grant/research support from Novartis, Bristol- Myers Squibb, Pfizer, and Lilly. Dr. P. Nash received grant/research support, and speakers’ bureau and consulting fees from Bristol-Myers Squibb. Dr. C.W. Legerton received grant/research support from AbbVie, Ablynx, Acerta, Amgen, AstraZeneca, Celgene, GSK, Janssen, Lilly, Bristol-Myers Squibb, Pfizer, Novartis, Sandoz, UCB Pharma, Daiichi Sankyo, ChemoCentryx, and Boehringer Ingelheim, and speakers’ bureau fees from Celgene, Amgen, and Novartis. Dr. A. Elegbe, Dr. R. Wong, Dr. X. Li, and Dr. S. Banerjee are shareholders and employees of Bristol-Myers Squibb. M.C. Genovese, MD, Stanford University; C. Pacheco-Tena, MD, PhD, Universidad Autónoma de Chihuahua; A. Covarrubias, MD, Unidad Reumatológica Las Américas S.C.P.; G. Leon, MD, Instituto De Ginecología Y Reproducción; E. Mysler, MD, Organización Médica de Investigación; M. Keiserman, MD, Pontifical Catholic University; R.M. Valente, MD, Arthritis Center of Nebraska; P. Nash, MBBS (Hons), FRACP, University of Queensland; J.A. Simon-Campos, PhD, Köhler & Milstein Research; J. Box, MD, Box Arthritis and Rheumatology of the Carolinas; C.W. Legerton III, MD, Low Country Rheumatology; E. Nasonov, PhD, Russian Academy of Medical Sciences; P. Durez, MD, Cliniques Universitaires Saint-Luc, Université Catholique de Louvain; A. Elegbe, PhD, Bristol-Myers Squibb; R. Wong, MD, Bristol-Myers Squibb; X. Li, PhD, Bristol-Myers Squibb; S. Banerjee, MD, Bristol-Myers Squibb; R. Alten, MD, PhD, Schlosspark-Klinik University Medicine. Address correspondence to Dr. M.C. Genovese, Stanford University, Division of Immunology and Rheumatology, 1000 Welch Road #203, Palo Alto, California 94304, USA. E-mail: genovese@stanford.edu. Accepted for publication December 18, 2017.
César Pacheco-Tena
From Stanford University, Palo Alto, California; Arthritis Center of Nebraska, Lincoln, Nebraska; Box Arthritis and Rheumatology of the Carolinas, Charlotte, North Carolina; Low Country Rheumatology, Charleston, South Carolina; Bristol-Myers Squibb, Princeton, New Jersey, USA; Universidad Autónoma de Chihuahua, Chihuahua; Unidad Reumatológica Las Américas S.C.P., Mérida; Köhler & Milstein Research, Mérida, Mexico; Instituto De Ginecología Y Reproducción, Lima, Peru; Organización Médica de Investigación, Buenos Aires, Argentina; Pontifical Catholic University, Porto Alegre, Brazil; University of Queensland, Brisbane, Australia; Russian Academy of Medical Sciences, Moscow, Russia; Cliniques Universitaires Saint-Luc; Université Catholique de Louvain, Brussels, Belgium; Schlosspark-Klinik University Medicine, Berlin, Germany. This study was sponsored by Bristol-Myers Squibb. Dr. R.M. Valente received grant/research support from Novartis, Bristol- Myers Squibb, Pfizer, and Lilly. Dr. P. Nash received grant/research support, and speakers’ bureau and consulting fees from Bristol-Myers Squibb. Dr. C.W. Legerton received grant/research support from AbbVie, Ablynx, Acerta, Amgen, AstraZeneca, Celgene, GSK, Janssen, Lilly, Bristol-Myers Squibb, Pfizer, Novartis, Sandoz, UCB Pharma, Daiichi Sankyo, ChemoCentryx, and Boehringer Ingelheim, and speakers’ bureau fees from Celgene, Amgen, and Novartis. Dr. A. Elegbe, Dr. R. Wong, Dr. X. Li, and Dr. S. Banerjee are shareholders and employees of Bristol-Myers Squibb. M.C. Genovese, MD, Stanford University; C. Pacheco-Tena, MD, PhD, Universidad Autónoma de Chihuahua; A. Covarrubias, MD, Unidad Reumatológica Las Américas S.C.P.; G. Leon, MD, Instituto De Ginecología Y Reproducción; E. Mysler, MD, Organización Médica de Investigación; M. Keiserman, MD, Pontifical Catholic University; R.M. Valente, MD, Arthritis Center of Nebraska; P. Nash, MBBS (Hons), FRACP, University of Queensland; J.A. Simon-Campos, PhD, Köhler & Milstein Research; J. Box, MD, Box Arthritis and Rheumatology of the Carolinas; C.W. Legerton III, MD, Low Country Rheumatology; E. Nasonov, PhD, Russian Academy of Medical Sciences; P. Durez, MD, Cliniques Universitaires Saint-Luc, Université Catholique de Louvain; A. Elegbe, PhD, Bristol-Myers Squibb; R. Wong, MD, Bristol-Myers Squibb; X. Li, PhD, Bristol-Myers Squibb; S. Banerjee, MD, Bristol-Myers Squibb; R. Alten, MD, PhD, Schlosspark-Klinik University Medicine. Address correspondence to Dr. M.C. Genovese, Stanford University, Division of Immunology and Rheumatology, 1000 Welch Road #203, Palo Alto, California 94304, USA. E-mail: genovese@stanford.edu. Accepted for publication December 18, 2017.
Arturo Covarrubias
From Stanford University, Palo Alto, California; Arthritis Center of Nebraska, Lincoln, Nebraska; Box Arthritis and Rheumatology of the Carolinas, Charlotte, North Carolina; Low Country Rheumatology, Charleston, South Carolina; Bristol-Myers Squibb, Princeton, New Jersey, USA; Universidad Autónoma de Chihuahua, Chihuahua; Unidad Reumatológica Las Américas S.C.P., Mérida; Köhler & Milstein Research, Mérida, Mexico; Instituto De Ginecología Y Reproducción, Lima, Peru; Organización Médica de Investigación, Buenos Aires, Argentina; Pontifical Catholic University, Porto Alegre, Brazil; University of Queensland, Brisbane, Australia; Russian Academy of Medical Sciences, Moscow, Russia; Cliniques Universitaires Saint-Luc; Université Catholique de Louvain, Brussels, Belgium; Schlosspark-Klinik University Medicine, Berlin, Germany. This study was sponsored by Bristol-Myers Squibb. Dr. R.M. Valente received grant/research support from Novartis, Bristol- Myers Squibb, Pfizer, and Lilly. Dr. P. Nash received grant/research support, and speakers’ bureau and consulting fees from Bristol-Myers Squibb. Dr. C.W. Legerton received grant/research support from AbbVie, Ablynx, Acerta, Amgen, AstraZeneca, Celgene, GSK, Janssen, Lilly, Bristol-Myers Squibb, Pfizer, Novartis, Sandoz, UCB Pharma, Daiichi Sankyo, ChemoCentryx, and Boehringer Ingelheim, and speakers’ bureau fees from Celgene, Amgen, and Novartis. Dr. A. Elegbe, Dr. R. Wong, Dr. X. Li, and Dr. S. Banerjee are shareholders and employees of Bristol-Myers Squibb. M.C. Genovese, MD, Stanford University; C. Pacheco-Tena, MD, PhD, Universidad Autónoma de Chihuahua; A. Covarrubias, MD, Unidad Reumatológica Las Américas S.C.P.; G. Leon, MD, Instituto De Ginecología Y Reproducción; E. Mysler, MD, Organización Médica de Investigación; M. Keiserman, MD, Pontifical Catholic University; R.M. Valente, MD, Arthritis Center of Nebraska; P. Nash, MBBS (Hons), FRACP, University of Queensland; J.A. Simon-Campos, PhD, Köhler & Milstein Research; J. Box, MD, Box Arthritis and Rheumatology of the Carolinas; C.W. Legerton III, MD, Low Country Rheumatology; E. Nasonov, PhD, Russian Academy of Medical Sciences; P. Durez, MD, Cliniques Universitaires Saint-Luc, Université Catholique de Louvain; A. Elegbe, PhD, Bristol-Myers Squibb; R. Wong, MD, Bristol-Myers Squibb; X. Li, PhD, Bristol-Myers Squibb; S. Banerjee, MD, Bristol-Myers Squibb; R. Alten, MD, PhD, Schlosspark-Klinik University Medicine. Address correspondence to Dr. M.C. Genovese, Stanford University, Division of Immunology and Rheumatology, 1000 Welch Road #203, Palo Alto, California 94304, USA. E-mail: genovese@stanford.edu. Accepted for publication December 18, 2017.
Gustavo Leon
From Stanford University, Palo Alto, California; Arthritis Center of Nebraska, Lincoln, Nebraska; Box Arthritis and Rheumatology of the Carolinas, Charlotte, North Carolina; Low Country Rheumatology, Charleston, South Carolina; Bristol-Myers Squibb, Princeton, New Jersey, USA; Universidad Autónoma de Chihuahua, Chihuahua; Unidad Reumatológica Las Américas S.C.P., Mérida; Köhler & Milstein Research, Mérida, Mexico; Instituto De Ginecología Y Reproducción, Lima, Peru; Organización Médica de Investigación, Buenos Aires, Argentina; Pontifical Catholic University, Porto Alegre, Brazil; University of Queensland, Brisbane, Australia; Russian Academy of Medical Sciences, Moscow, Russia; Cliniques Universitaires Saint-Luc; Université Catholique de Louvain, Brussels, Belgium; Schlosspark-Klinik University Medicine, Berlin, Germany. This study was sponsored by Bristol-Myers Squibb. Dr. R.M. Valente received grant/research support from Novartis, Bristol- Myers Squibb, Pfizer, and Lilly. Dr. P. Nash received grant/research support, and speakers’ bureau and consulting fees from Bristol-Myers Squibb. Dr. C.W. Legerton received grant/research support from AbbVie, Ablynx, Acerta, Amgen, AstraZeneca, Celgene, GSK, Janssen, Lilly, Bristol-Myers Squibb, Pfizer, Novartis, Sandoz, UCB Pharma, Daiichi Sankyo, ChemoCentryx, and Boehringer Ingelheim, and speakers’ bureau fees from Celgene, Amgen, and Novartis. Dr. A. Elegbe, Dr. R. Wong, Dr. X. Li, and Dr. S. Banerjee are shareholders and employees of Bristol-Myers Squibb. M.C. Genovese, MD, Stanford University; C. Pacheco-Tena, MD, PhD, Universidad Autónoma de Chihuahua; A. Covarrubias, MD, Unidad Reumatológica Las Américas S.C.P.; G. Leon, MD, Instituto De Ginecología Y Reproducción; E. Mysler, MD, Organización Médica de Investigación; M. Keiserman, MD, Pontifical Catholic University; R.M. Valente, MD, Arthritis Center of Nebraska; P. Nash, MBBS (Hons), FRACP, University of Queensland; J.A. Simon-Campos, PhD, Köhler & Milstein Research; J. Box, MD, Box Arthritis and Rheumatology of the Carolinas; C.W. Legerton III, MD, Low Country Rheumatology; E. Nasonov, PhD, Russian Academy of Medical Sciences; P. Durez, MD, Cliniques Universitaires Saint-Luc, Université Catholique de Louvain; A. Elegbe, PhD, Bristol-Myers Squibb; R. Wong, MD, Bristol-Myers Squibb; X. Li, PhD, Bristol-Myers Squibb; S. Banerjee, MD, Bristol-Myers Squibb; R. Alten, MD, PhD, Schlosspark-Klinik University Medicine. Address correspondence to Dr. M.C. Genovese, Stanford University, Division of Immunology and Rheumatology, 1000 Welch Road #203, Palo Alto, California 94304, USA. E-mail: genovese@stanford.edu. Accepted for publication December 18, 2017.
Eduardo Mysler
From Stanford University, Palo Alto, California; Arthritis Center of Nebraska, Lincoln, Nebraska; Box Arthritis and Rheumatology of the Carolinas, Charlotte, North Carolina; Low Country Rheumatology, Charleston, South Carolina; Bristol-Myers Squibb, Princeton, New Jersey, USA; Universidad Autónoma de Chihuahua, Chihuahua; Unidad Reumatológica Las Américas S.C.P., Mérida; Köhler & Milstein Research, Mérida, Mexico; Instituto De Ginecología Y Reproducción, Lima, Peru; Organización Médica de Investigación, Buenos Aires, Argentina; Pontifical Catholic University, Porto Alegre, Brazil; University of Queensland, Brisbane, Australia; Russian Academy of Medical Sciences, Moscow, Russia; Cliniques Universitaires Saint-Luc; Université Catholique de Louvain, Brussels, Belgium; Schlosspark-Klinik University Medicine, Berlin, Germany. This study was sponsored by Bristol-Myers Squibb. Dr. R.M. Valente received grant/research support from Novartis, Bristol- Myers Squibb, Pfizer, and Lilly. Dr. P. Nash received grant/research support, and speakers’ bureau and consulting fees from Bristol-Myers Squibb. Dr. C.W. Legerton received grant/research support from AbbVie, Ablynx, Acerta, Amgen, AstraZeneca, Celgene, GSK, Janssen, Lilly, Bristol-Myers Squibb, Pfizer, Novartis, Sandoz, UCB Pharma, Daiichi Sankyo, ChemoCentryx, and Boehringer Ingelheim, and speakers’ bureau fees from Celgene, Amgen, and Novartis. Dr. A. Elegbe, Dr. R. Wong, Dr. X. Li, and Dr. S. Banerjee are shareholders and employees of Bristol-Myers Squibb. M.C. Genovese, MD, Stanford University; C. Pacheco-Tena, MD, PhD, Universidad Autónoma de Chihuahua; A. Covarrubias, MD, Unidad Reumatológica Las Américas S.C.P.; G. Leon, MD, Instituto De Ginecología Y Reproducción; E. Mysler, MD, Organización Médica de Investigación; M. Keiserman, MD, Pontifical Catholic University; R.M. Valente, MD, Arthritis Center of Nebraska; P. Nash, MBBS (Hons), FRACP, University of Queensland; J.A. Simon-Campos, PhD, Köhler & Milstein Research; J. Box, MD, Box Arthritis and Rheumatology of the Carolinas; C.W. Legerton III, MD, Low Country Rheumatology; E. Nasonov, PhD, Russian Academy of Medical Sciences; P. Durez, MD, Cliniques Universitaires Saint-Luc, Université Catholique de Louvain; A. Elegbe, PhD, Bristol-Myers Squibb; R. Wong, MD, Bristol-Myers Squibb; X. Li, PhD, Bristol-Myers Squibb; S. Banerjee, MD, Bristol-Myers Squibb; R. Alten, MD, PhD, Schlosspark-Klinik University Medicine. Address correspondence to Dr. M.C. Genovese, Stanford University, Division of Immunology and Rheumatology, 1000 Welch Road #203, Palo Alto, California 94304, USA. E-mail: genovese@stanford.edu. Accepted for publication December 18, 2017.
Mauro Keiserman
From Stanford University, Palo Alto, California; Arthritis Center of Nebraska, Lincoln, Nebraska; Box Arthritis and Rheumatology of the Carolinas, Charlotte, North Carolina; Low Country Rheumatology, Charleston, South Carolina; Bristol-Myers Squibb, Princeton, New Jersey, USA; Universidad Autónoma de Chihuahua, Chihuahua; Unidad Reumatológica Las Américas S.C.P., Mérida; Köhler & Milstein Research, Mérida, Mexico; Instituto De Ginecología Y Reproducción, Lima, Peru; Organización Médica de Investigación, Buenos Aires, Argentina; Pontifical Catholic University, Porto Alegre, Brazil; University of Queensland, Brisbane, Australia; Russian Academy of Medical Sciences, Moscow, Russia; Cliniques Universitaires Saint-Luc; Université Catholique de Louvain, Brussels, Belgium; Schlosspark-Klinik University Medicine, Berlin, Germany. This study was sponsored by Bristol-Myers Squibb. Dr. R.M. Valente received grant/research support from Novartis, Bristol- Myers Squibb, Pfizer, and Lilly. Dr. P. Nash received grant/research support, and speakers’ bureau and consulting fees from Bristol-Myers Squibb. Dr. C.W. Legerton received grant/research support from AbbVie, Ablynx, Acerta, Amgen, AstraZeneca, Celgene, GSK, Janssen, Lilly, Bristol-Myers Squibb, Pfizer, Novartis, Sandoz, UCB Pharma, Daiichi Sankyo, ChemoCentryx, and Boehringer Ingelheim, and speakers’ bureau fees from Celgene, Amgen, and Novartis. Dr. A. Elegbe, Dr. R. Wong, Dr. X. Li, and Dr. S. Banerjee are shareholders and employees of Bristol-Myers Squibb. M.C. Genovese, MD, Stanford University; C. Pacheco-Tena, MD, PhD, Universidad Autónoma de Chihuahua; A. Covarrubias, MD, Unidad Reumatológica Las Américas S.C.P.; G. Leon, MD, Instituto De Ginecología Y Reproducción; E. Mysler, MD, Organización Médica de Investigación; M. Keiserman, MD, Pontifical Catholic University; R.M. Valente, MD, Arthritis Center of Nebraska; P. Nash, MBBS (Hons), FRACP, University of Queensland; J.A. Simon-Campos, PhD, Köhler & Milstein Research; J. Box, MD, Box Arthritis and Rheumatology of the Carolinas; C.W. Legerton III, MD, Low Country Rheumatology; E. Nasonov, PhD, Russian Academy of Medical Sciences; P. Durez, MD, Cliniques Universitaires Saint-Luc, Université Catholique de Louvain; A. Elegbe, PhD, Bristol-Myers Squibb; R. Wong, MD, Bristol-Myers Squibb; X. Li, PhD, Bristol-Myers Squibb; S. Banerjee, MD, Bristol-Myers Squibb; R. Alten, MD, PhD, Schlosspark-Klinik University Medicine. Address correspondence to Dr. M.C. Genovese, Stanford University, Division of Immunology and Rheumatology, 1000 Welch Road #203, Palo Alto, California 94304, USA. E-mail: genovese@stanford.edu. Accepted for publication December 18, 2017.
Robert M. Valente
From Stanford University, Palo Alto, California; Arthritis Center of Nebraska, Lincoln, Nebraska; Box Arthritis and Rheumatology of the Carolinas, Charlotte, North Carolina; Low Country Rheumatology, Charleston, South Carolina; Bristol-Myers Squibb, Princeton, New Jersey, USA; Universidad Autónoma de Chihuahua, Chihuahua; Unidad Reumatológica Las Américas S.C.P., Mérida; Köhler & Milstein Research, Mérida, Mexico; Instituto De Ginecología Y Reproducción, Lima, Peru; Organización Médica de Investigación, Buenos Aires, Argentina; Pontifical Catholic University, Porto Alegre, Brazil; University of Queensland, Brisbane, Australia; Russian Academy of Medical Sciences, Moscow, Russia; Cliniques Universitaires Saint-Luc; Université Catholique de Louvain, Brussels, Belgium; Schlosspark-Klinik University Medicine, Berlin, Germany. This study was sponsored by Bristol-Myers Squibb. Dr. R.M. Valente received grant/research support from Novartis, Bristol- Myers Squibb, Pfizer, and Lilly. Dr. P. Nash received grant/research support, and speakers’ bureau and consulting fees from Bristol-Myers Squibb. Dr. C.W. Legerton received grant/research support from AbbVie, Ablynx, Acerta, Amgen, AstraZeneca, Celgene, GSK, Janssen, Lilly, Bristol-Myers Squibb, Pfizer, Novartis, Sandoz, UCB Pharma, Daiichi Sankyo, ChemoCentryx, and Boehringer Ingelheim, and speakers’ bureau fees from Celgene, Amgen, and Novartis. Dr. A. Elegbe, Dr. R. Wong, Dr. X. Li, and Dr. S. Banerjee are shareholders and employees of Bristol-Myers Squibb. M.C. Genovese, MD, Stanford University; C. Pacheco-Tena, MD, PhD, Universidad Autónoma de Chihuahua; A. Covarrubias, MD, Unidad Reumatológica Las Américas S.C.P.; G. Leon, MD, Instituto De Ginecología Y Reproducción; E. Mysler, MD, Organización Médica de Investigación; M. Keiserman, MD, Pontifical Catholic University; R.M. Valente, MD, Arthritis Center of Nebraska; P. Nash, MBBS (Hons), FRACP, University of Queensland; J.A. Simon-Campos, PhD, Köhler & Milstein Research; J. Box, MD, Box Arthritis and Rheumatology of the Carolinas; C.W. Legerton III, MD, Low Country Rheumatology; E. Nasonov, PhD, Russian Academy of Medical Sciences; P. Durez, MD, Cliniques Universitaires Saint-Luc, Université Catholique de Louvain; A. Elegbe, PhD, Bristol-Myers Squibb; R. Wong, MD, Bristol-Myers Squibb; X. Li, PhD, Bristol-Myers Squibb; S. Banerjee, MD, Bristol-Myers Squibb; R. Alten, MD, PhD, Schlosspark-Klinik University Medicine. Address correspondence to Dr. M.C. Genovese, Stanford University, Division of Immunology and Rheumatology, 1000 Welch Road #203, Palo Alto, California 94304, USA. E-mail: genovese@stanford.edu. Accepted for publication December 18, 2017.
Peter Nash
From Stanford University, Palo Alto, California; Arthritis Center of Nebraska, Lincoln, Nebraska; Box Arthritis and Rheumatology of the Carolinas, Charlotte, North Carolina; Low Country Rheumatology, Charleston, South Carolina; Bristol-Myers Squibb, Princeton, New Jersey, USA; Universidad Autónoma de Chihuahua, Chihuahua; Unidad Reumatológica Las Américas S.C.P., Mérida; Köhler & Milstein Research, Mérida, Mexico; Instituto De Ginecología Y Reproducción, Lima, Peru; Organización Médica de Investigación, Buenos Aires, Argentina; Pontifical Catholic University, Porto Alegre, Brazil; University of Queensland, Brisbane, Australia; Russian Academy of Medical Sciences, Moscow, Russia; Cliniques Universitaires Saint-Luc; Université Catholique de Louvain, Brussels, Belgium; Schlosspark-Klinik University Medicine, Berlin, Germany. This study was sponsored by Bristol-Myers Squibb. Dr. R.M. Valente received grant/research support from Novartis, Bristol- Myers Squibb, Pfizer, and Lilly. Dr. P. Nash received grant/research support, and speakers’ bureau and consulting fees from Bristol-Myers Squibb. Dr. C.W. Legerton received grant/research support from AbbVie, Ablynx, Acerta, Amgen, AstraZeneca, Celgene, GSK, Janssen, Lilly, Bristol-Myers Squibb, Pfizer, Novartis, Sandoz, UCB Pharma, Daiichi Sankyo, ChemoCentryx, and Boehringer Ingelheim, and speakers’ bureau fees from Celgene, Amgen, and Novartis. Dr. A. Elegbe, Dr. R. Wong, Dr. X. Li, and Dr. S. Banerjee are shareholders and employees of Bristol-Myers Squibb. M.C. Genovese, MD, Stanford University; C. Pacheco-Tena, MD, PhD, Universidad Autónoma de Chihuahua; A. Covarrubias, MD, Unidad Reumatológica Las Américas S.C.P.; G. Leon, MD, Instituto De Ginecología Y Reproducción; E. Mysler, MD, Organización Médica de Investigación; M. Keiserman, MD, Pontifical Catholic University; R.M. Valente, MD, Arthritis Center of Nebraska; P. Nash, MBBS (Hons), FRACP, University of Queensland; J.A. Simon-Campos, PhD, Köhler & Milstein Research; J. Box, MD, Box Arthritis and Rheumatology of the Carolinas; C.W. Legerton III, MD, Low Country Rheumatology; E. Nasonov, PhD, Russian Academy of Medical Sciences; P. Durez, MD, Cliniques Universitaires Saint-Luc, Université Catholique de Louvain; A. Elegbe, PhD, Bristol-Myers Squibb; R. Wong, MD, Bristol-Myers Squibb; X. Li, PhD, Bristol-Myers Squibb; S. Banerjee, MD, Bristol-Myers Squibb; R. Alten, MD, PhD, Schlosspark-Klinik University Medicine. Address correspondence to Dr. M.C. Genovese, Stanford University, Division of Immunology and Rheumatology, 1000 Welch Road #203, Palo Alto, California 94304, USA. E-mail: genovese@stanford.edu. Accepted for publication December 18, 2017.
J. Abraham Simon-Campos
From Stanford University, Palo Alto, California; Arthritis Center of Nebraska, Lincoln, Nebraska; Box Arthritis and Rheumatology of the Carolinas, Charlotte, North Carolina; Low Country Rheumatology, Charleston, South Carolina; Bristol-Myers Squibb, Princeton, New Jersey, USA; Universidad Autónoma de Chihuahua, Chihuahua; Unidad Reumatológica Las Américas S.C.P., Mérida; Köhler & Milstein Research, Mérida, Mexico; Instituto De Ginecología Y Reproducción, Lima, Peru; Organización Médica de Investigación, Buenos Aires, Argentina; Pontifical Catholic University, Porto Alegre, Brazil; University of Queensland, Brisbane, Australia; Russian Academy of Medical Sciences, Moscow, Russia; Cliniques Universitaires Saint-Luc; Université Catholique de Louvain, Brussels, Belgium; Schlosspark-Klinik University Medicine, Berlin, Germany. This study was sponsored by Bristol-Myers Squibb. Dr. R.M. Valente received grant/research support from Novartis, Bristol- Myers Squibb, Pfizer, and Lilly. Dr. P. Nash received grant/research support, and speakers’ bureau and consulting fees from Bristol-Myers Squibb. Dr. C.W. Legerton received grant/research support from AbbVie, Ablynx, Acerta, Amgen, AstraZeneca, Celgene, GSK, Janssen, Lilly, Bristol-Myers Squibb, Pfizer, Novartis, Sandoz, UCB Pharma, Daiichi Sankyo, ChemoCentryx, and Boehringer Ingelheim, and speakers’ bureau fees from Celgene, Amgen, and Novartis. Dr. A. Elegbe, Dr. R. Wong, Dr. X. Li, and Dr. S. Banerjee are shareholders and employees of Bristol-Myers Squibb. M.C. Genovese, MD, Stanford University; C. Pacheco-Tena, MD, PhD, Universidad Autónoma de Chihuahua; A. Covarrubias, MD, Unidad Reumatológica Las Américas S.C.P.; G. Leon, MD, Instituto De Ginecología Y Reproducción; E. Mysler, MD, Organización Médica de Investigación; M. Keiserman, MD, Pontifical Catholic University; R.M. Valente, MD, Arthritis Center of Nebraska; P. Nash, MBBS (Hons), FRACP, University of Queensland; J.A. Simon-Campos, PhD, Köhler & Milstein Research; J. Box, MD, Box Arthritis and Rheumatology of the Carolinas; C.W. Legerton III, MD, Low Country Rheumatology; E. Nasonov, PhD, Russian Academy of Medical Sciences; P. Durez, MD, Cliniques Universitaires Saint-Luc, Université Catholique de Louvain; A. Elegbe, PhD, Bristol-Myers Squibb; R. Wong, MD, Bristol-Myers Squibb; X. Li, PhD, Bristol-Myers Squibb; S. Banerjee, MD, Bristol-Myers Squibb; R. Alten, MD, PhD, Schlosspark-Klinik University Medicine. Address correspondence to Dr. M.C. Genovese, Stanford University, Division of Immunology and Rheumatology, 1000 Welch Road #203, Palo Alto, California 94304, USA. E-mail: genovese@stanford.edu. Accepted for publication December 18, 2017.
Jane Box
From Stanford University, Palo Alto, California; Arthritis Center of Nebraska, Lincoln, Nebraska; Box Arthritis and Rheumatology of the Carolinas, Charlotte, North Carolina; Low Country Rheumatology, Charleston, South Carolina; Bristol-Myers Squibb, Princeton, New Jersey, USA; Universidad Autónoma de Chihuahua, Chihuahua; Unidad Reumatológica Las Américas S.C.P., Mérida; Köhler & Milstein Research, Mérida, Mexico; Instituto De Ginecología Y Reproducción, Lima, Peru; Organización Médica de Investigación, Buenos Aires, Argentina; Pontifical Catholic University, Porto Alegre, Brazil; University of Queensland, Brisbane, Australia; Russian Academy of Medical Sciences, Moscow, Russia; Cliniques Universitaires Saint-Luc; Université Catholique de Louvain, Brussels, Belgium; Schlosspark-Klinik University Medicine, Berlin, Germany. This study was sponsored by Bristol-Myers Squibb. Dr. R.M. Valente received grant/research support from Novartis, Bristol- Myers Squibb, Pfizer, and Lilly. Dr. P. Nash received grant/research support, and speakers’ bureau and consulting fees from Bristol-Myers Squibb. Dr. C.W. Legerton received grant/research support from AbbVie, Ablynx, Acerta, Amgen, AstraZeneca, Celgene, GSK, Janssen, Lilly, Bristol-Myers Squibb, Pfizer, Novartis, Sandoz, UCB Pharma, Daiichi Sankyo, ChemoCentryx, and Boehringer Ingelheim, and speakers’ bureau fees from Celgene, Amgen, and Novartis. Dr. A. Elegbe, Dr. R. Wong, Dr. X. Li, and Dr. S. Banerjee are shareholders and employees of Bristol-Myers Squibb. M.C. Genovese, MD, Stanford University; C. Pacheco-Tena, MD, PhD, Universidad Autónoma de Chihuahua; A. Covarrubias, MD, Unidad Reumatológica Las Américas S.C.P.; G. Leon, MD, Instituto De Ginecología Y Reproducción; E. Mysler, MD, Organización Médica de Investigación; M. Keiserman, MD, Pontifical Catholic University; R.M. Valente, MD, Arthritis Center of Nebraska; P. Nash, MBBS (Hons), FRACP, University of Queensland; J.A. Simon-Campos, PhD, Köhler & Milstein Research; J. Box, MD, Box Arthritis and Rheumatology of the Carolinas; C.W. Legerton III, MD, Low Country Rheumatology; E. Nasonov, PhD, Russian Academy of Medical Sciences; P. Durez, MD, Cliniques Universitaires Saint-Luc, Université Catholique de Louvain; A. Elegbe, PhD, Bristol-Myers Squibb; R. Wong, MD, Bristol-Myers Squibb; X. Li, PhD, Bristol-Myers Squibb; S. Banerjee, MD, Bristol-Myers Squibb; R. Alten, MD, PhD, Schlosspark-Klinik University Medicine. Address correspondence to Dr. M.C. Genovese, Stanford University, Division of Immunology and Rheumatology, 1000 Welch Road #203, Palo Alto, California 94304, USA. E-mail: genovese@stanford.edu. Accepted for publication December 18, 2017.
Clarence W. Legerton III
From Stanford University, Palo Alto, California; Arthritis Center of Nebraska, Lincoln, Nebraska; Box Arthritis and Rheumatology of the Carolinas, Charlotte, North Carolina; Low Country Rheumatology, Charleston, South Carolina; Bristol-Myers Squibb, Princeton, New Jersey, USA; Universidad Autónoma de Chihuahua, Chihuahua; Unidad Reumatológica Las Américas S.C.P., Mérida; Köhler & Milstein Research, Mérida, Mexico; Instituto De Ginecología Y Reproducción, Lima, Peru; Organización Médica de Investigación, Buenos Aires, Argentina; Pontifical Catholic University, Porto Alegre, Brazil; University of Queensland, Brisbane, Australia; Russian Academy of Medical Sciences, Moscow, Russia; Cliniques Universitaires Saint-Luc; Université Catholique de Louvain, Brussels, Belgium; Schlosspark-Klinik University Medicine, Berlin, Germany. This study was sponsored by Bristol-Myers Squibb. Dr. R.M. Valente received grant/research support from Novartis, Bristol- Myers Squibb, Pfizer, and Lilly. Dr. P. Nash received grant/research support, and speakers’ bureau and consulting fees from Bristol-Myers Squibb. Dr. C.W. Legerton received grant/research support from AbbVie, Ablynx, Acerta, Amgen, AstraZeneca, Celgene, GSK, Janssen, Lilly, Bristol-Myers Squibb, Pfizer, Novartis, Sandoz, UCB Pharma, Daiichi Sankyo, ChemoCentryx, and Boehringer Ingelheim, and speakers’ bureau fees from Celgene, Amgen, and Novartis. Dr. A. Elegbe, Dr. R. Wong, Dr. X. Li, and Dr. S. Banerjee are shareholders and employees of Bristol-Myers Squibb. M.C. Genovese, MD, Stanford University; C. Pacheco-Tena, MD, PhD, Universidad Autónoma de Chihuahua; A. Covarrubias, MD, Unidad Reumatológica Las Américas S.C.P.; G. Leon, MD, Instituto De Ginecología Y Reproducción; E. Mysler, MD, Organización Médica de Investigación; M. Keiserman, MD, Pontifical Catholic University; R.M. Valente, MD, Arthritis Center of Nebraska; P. Nash, MBBS (Hons), FRACP, University of Queensland; J.A. Simon-Campos, PhD, Köhler & Milstein Research; J. Box, MD, Box Arthritis and Rheumatology of the Carolinas; C.W. Legerton III, MD, Low Country Rheumatology; E. Nasonov, PhD, Russian Academy of Medical Sciences; P. Durez, MD, Cliniques Universitaires Saint-Luc, Université Catholique de Louvain; A. Elegbe, PhD, Bristol-Myers Squibb; R. Wong, MD, Bristol-Myers Squibb; X. Li, PhD, Bristol-Myers Squibb; S. Banerjee, MD, Bristol-Myers Squibb; R. Alten, MD, PhD, Schlosspark-Klinik University Medicine. Address correspondence to Dr. M.C. Genovese, Stanford University, Division of Immunology and Rheumatology, 1000 Welch Road #203, Palo Alto, California 94304, USA. E-mail: genovese@stanford.edu. Accepted for publication December 18, 2017.
Evgeny Nasonov
From Stanford University, Palo Alto, California; Arthritis Center of Nebraska, Lincoln, Nebraska; Box Arthritis and Rheumatology of the Carolinas, Charlotte, North Carolina; Low Country Rheumatology, Charleston, South Carolina; Bristol-Myers Squibb, Princeton, New Jersey, USA; Universidad Autónoma de Chihuahua, Chihuahua; Unidad Reumatológica Las Américas S.C.P., Mérida; Köhler & Milstein Research, Mérida, Mexico; Instituto De Ginecología Y Reproducción, Lima, Peru; Organización Médica de Investigación, Buenos Aires, Argentina; Pontifical Catholic University, Porto Alegre, Brazil; University of Queensland, Brisbane, Australia; Russian Academy of Medical Sciences, Moscow, Russia; Cliniques Universitaires Saint-Luc; Université Catholique de Louvain, Brussels, Belgium; Schlosspark-Klinik University Medicine, Berlin, Germany. This study was sponsored by Bristol-Myers Squibb. Dr. R.M. Valente received grant/research support from Novartis, Bristol- Myers Squibb, Pfizer, and Lilly. Dr. P. Nash received grant/research support, and speakers’ bureau and consulting fees from Bristol-Myers Squibb. Dr. C.W. Legerton received grant/research support from AbbVie, Ablynx, Acerta, Amgen, AstraZeneca, Celgene, GSK, Janssen, Lilly, Bristol-Myers Squibb, Pfizer, Novartis, Sandoz, UCB Pharma, Daiichi Sankyo, ChemoCentryx, and Boehringer Ingelheim, and speakers’ bureau fees from Celgene, Amgen, and Novartis. Dr. A. Elegbe, Dr. R. Wong, Dr. X. Li, and Dr. S. Banerjee are shareholders and employees of Bristol-Myers Squibb. M.C. Genovese, MD, Stanford University; C. Pacheco-Tena, MD, PhD, Universidad Autónoma de Chihuahua; A. Covarrubias, MD, Unidad Reumatológica Las Américas S.C.P.; G. Leon, MD, Instituto De Ginecología Y Reproducción; E. Mysler, MD, Organización Médica de Investigación; M. Keiserman, MD, Pontifical Catholic University; R.M. Valente, MD, Arthritis Center of Nebraska; P. Nash, MBBS (Hons), FRACP, University of Queensland; J.A. Simon-Campos, PhD, Köhler & Milstein Research; J. Box, MD, Box Arthritis and Rheumatology of the Carolinas; C.W. Legerton III, MD, Low Country Rheumatology; E. Nasonov, PhD, Russian Academy of Medical Sciences; P. Durez, MD, Cliniques Universitaires Saint-Luc, Université Catholique de Louvain; A. Elegbe, PhD, Bristol-Myers Squibb; R. Wong, MD, Bristol-Myers Squibb; X. Li, PhD, Bristol-Myers Squibb; S. Banerjee, MD, Bristol-Myers Squibb; R. Alten, MD, PhD, Schlosspark-Klinik University Medicine. Address correspondence to Dr. M.C. Genovese, Stanford University, Division of Immunology and Rheumatology, 1000 Welch Road #203, Palo Alto, California 94304, USA. E-mail: genovese@stanford.edu. Accepted for publication December 18, 2017.
Patrick Durez
From Stanford University, Palo Alto, California; Arthritis Center of Nebraska, Lincoln, Nebraska; Box Arthritis and Rheumatology of the Carolinas, Charlotte, North Carolina; Low Country Rheumatology, Charleston, South Carolina; Bristol-Myers Squibb, Princeton, New Jersey, USA; Universidad Autónoma de Chihuahua, Chihuahua; Unidad Reumatológica Las Américas S.C.P., Mérida; Köhler & Milstein Research, Mérida, Mexico; Instituto De Ginecología Y Reproducción, Lima, Peru; Organización Médica de Investigación, Buenos Aires, Argentina; Pontifical Catholic University, Porto Alegre, Brazil; University of Queensland, Brisbane, Australia; Russian Academy of Medical Sciences, Moscow, Russia; Cliniques Universitaires Saint-Luc; Université Catholique de Louvain, Brussels, Belgium; Schlosspark-Klinik University Medicine, Berlin, Germany. This study was sponsored by Bristol-Myers Squibb. Dr. R.M. Valente received grant/research support from Novartis, Bristol- Myers Squibb, Pfizer, and Lilly. Dr. P. Nash received grant/research support, and speakers’ bureau and consulting fees from Bristol-Myers Squibb. Dr. C.W. Legerton received grant/research support from AbbVie, Ablynx, Acerta, Amgen, AstraZeneca, Celgene, GSK, Janssen, Lilly, Bristol-Myers Squibb, Pfizer, Novartis, Sandoz, UCB Pharma, Daiichi Sankyo, ChemoCentryx, and Boehringer Ingelheim, and speakers’ bureau fees from Celgene, Amgen, and Novartis. Dr. A. Elegbe, Dr. R. Wong, Dr. X. Li, and Dr. S. Banerjee are shareholders and employees of Bristol-Myers Squibb. M.C. Genovese, MD, Stanford University; C. Pacheco-Tena, MD, PhD, Universidad Autónoma de Chihuahua; A. Covarrubias, MD, Unidad Reumatológica Las Américas S.C.P.; G. Leon, MD, Instituto De Ginecología Y Reproducción; E. Mysler, MD, Organización Médica de Investigación; M. Keiserman, MD, Pontifical Catholic University; R.M. Valente, MD, Arthritis Center of Nebraska; P. Nash, MBBS (Hons), FRACP, University of Queensland; J.A. Simon-Campos, PhD, Köhler & Milstein Research; J. Box, MD, Box Arthritis and Rheumatology of the Carolinas; C.W. Legerton III, MD, Low Country Rheumatology; E. Nasonov, PhD, Russian Academy of Medical Sciences; P. Durez, MD, Cliniques Universitaires Saint-Luc, Université Catholique de Louvain; A. Elegbe, PhD, Bristol-Myers Squibb; R. Wong, MD, Bristol-Myers Squibb; X. Li, PhD, Bristol-Myers Squibb; S. Banerjee, MD, Bristol-Myers Squibb; R. Alten, MD, PhD, Schlosspark-Klinik University Medicine. Address correspondence to Dr. M.C. Genovese, Stanford University, Division of Immunology and Rheumatology, 1000 Welch Road #203, Palo Alto, California 94304, USA. E-mail: genovese@stanford.edu. Accepted for publication December 18, 2017.
Ayanbola Elegbe
From Stanford University, Palo Alto, California; Arthritis Center of Nebraska, Lincoln, Nebraska; Box Arthritis and Rheumatology of the Carolinas, Charlotte, North Carolina; Low Country Rheumatology, Charleston, South Carolina; Bristol-Myers Squibb, Princeton, New Jersey, USA; Universidad Autónoma de Chihuahua, Chihuahua; Unidad Reumatológica Las Américas S.C.P., Mérida; Köhler & Milstein Research, Mérida, Mexico; Instituto De Ginecología Y Reproducción, Lima, Peru; Organización Médica de Investigación, Buenos Aires, Argentina; Pontifical Catholic University, Porto Alegre, Brazil; University of Queensland, Brisbane, Australia; Russian Academy of Medical Sciences, Moscow, Russia; Cliniques Universitaires Saint-Luc; Université Catholique de Louvain, Brussels, Belgium; Schlosspark-Klinik University Medicine, Berlin, Germany. This study was sponsored by Bristol-Myers Squibb. Dr. R.M. Valente received grant/research support from Novartis, Bristol- Myers Squibb, Pfizer, and Lilly. Dr. P. Nash received grant/research support, and speakers’ bureau and consulting fees from Bristol-Myers Squibb. Dr. C.W. Legerton received grant/research support from AbbVie, Ablynx, Acerta, Amgen, AstraZeneca, Celgene, GSK, Janssen, Lilly, Bristol-Myers Squibb, Pfizer, Novartis, Sandoz, UCB Pharma, Daiichi Sankyo, ChemoCentryx, and Boehringer Ingelheim, and speakers’ bureau fees from Celgene, Amgen, and Novartis. Dr. A. Elegbe, Dr. R. Wong, Dr. X. Li, and Dr. S. Banerjee are shareholders and employees of Bristol-Myers Squibb. M.C. Genovese, MD, Stanford University; C. Pacheco-Tena, MD, PhD, Universidad Autónoma de Chihuahua; A. Covarrubias, MD, Unidad Reumatológica Las Américas S.C.P.; G. Leon, MD, Instituto De Ginecología Y Reproducción; E. Mysler, MD, Organización Médica de Investigación; M. Keiserman, MD, Pontifical Catholic University; R.M. Valente, MD, Arthritis Center of Nebraska; P. Nash, MBBS (Hons), FRACP, University of Queensland; J.A. Simon-Campos, PhD, Köhler & Milstein Research; J. Box, MD, Box Arthritis and Rheumatology of the Carolinas; C.W. Legerton III, MD, Low Country Rheumatology; E. Nasonov, PhD, Russian Academy of Medical Sciences; P. Durez, MD, Cliniques Universitaires Saint-Luc, Université Catholique de Louvain; A. Elegbe, PhD, Bristol-Myers Squibb; R. Wong, MD, Bristol-Myers Squibb; X. Li, PhD, Bristol-Myers Squibb; S. Banerjee, MD, Bristol-Myers Squibb; R. Alten, MD, PhD, Schlosspark-Klinik University Medicine. Address correspondence to Dr. M.C. Genovese, Stanford University, Division of Immunology and Rheumatology, 1000 Welch Road #203, Palo Alto, California 94304, USA. E-mail: genovese@stanford.edu. Accepted for publication December 18, 2017.
Robert Wong
From Stanford University, Palo Alto, California; Arthritis Center of Nebraska, Lincoln, Nebraska; Box Arthritis and Rheumatology of the Carolinas, Charlotte, North Carolina; Low Country Rheumatology, Charleston, South Carolina; Bristol-Myers Squibb, Princeton, New Jersey, USA; Universidad Autónoma de Chihuahua, Chihuahua; Unidad Reumatológica Las Américas S.C.P., Mérida; Köhler & Milstein Research, Mérida, Mexico; Instituto De Ginecología Y Reproducción, Lima, Peru; Organización Médica de Investigación, Buenos Aires, Argentina; Pontifical Catholic University, Porto Alegre, Brazil; University of Queensland, Brisbane, Australia; Russian Academy of Medical Sciences, Moscow, Russia; Cliniques Universitaires Saint-Luc; Université Catholique de Louvain, Brussels, Belgium; Schlosspark-Klinik University Medicine, Berlin, Germany. This study was sponsored by Bristol-Myers Squibb. Dr. R.M. Valente received grant/research support from Novartis, Bristol- Myers Squibb, Pfizer, and Lilly. Dr. P. Nash received grant/research support, and speakers’ bureau and consulting fees from Bristol-Myers Squibb. Dr. C.W. Legerton received grant/research support from AbbVie, Ablynx, Acerta, Amgen, AstraZeneca, Celgene, GSK, Janssen, Lilly, Bristol-Myers Squibb, Pfizer, Novartis, Sandoz, UCB Pharma, Daiichi Sankyo, ChemoCentryx, and Boehringer Ingelheim, and speakers’ bureau fees from Celgene, Amgen, and Novartis. Dr. A. Elegbe, Dr. R. Wong, Dr. X. Li, and Dr. S. Banerjee are shareholders and employees of Bristol-Myers Squibb. M.C. Genovese, MD, Stanford University; C. Pacheco-Tena, MD, PhD, Universidad Autónoma de Chihuahua; A. Covarrubias, MD, Unidad Reumatológica Las Américas S.C.P.; G. Leon, MD, Instituto De Ginecología Y Reproducción; E. Mysler, MD, Organización Médica de Investigación; M. Keiserman, MD, Pontifical Catholic University; R.M. Valente, MD, Arthritis Center of Nebraska; P. Nash, MBBS (Hons), FRACP, University of Queensland; J.A. Simon-Campos, PhD, Köhler & Milstein Research; J. Box, MD, Box Arthritis and Rheumatology of the Carolinas; C.W. Legerton III, MD, Low Country Rheumatology; E. Nasonov, PhD, Russian Academy of Medical Sciences; P. Durez, MD, Cliniques Universitaires Saint-Luc, Université Catholique de Louvain; A. Elegbe, PhD, Bristol-Myers Squibb; R. Wong, MD, Bristol-Myers Squibb; X. Li, PhD, Bristol-Myers Squibb; S. Banerjee, MD, Bristol-Myers Squibb; R. Alten, MD, PhD, Schlosspark-Klinik University Medicine. Address correspondence to Dr. M.C. Genovese, Stanford University, Division of Immunology and Rheumatology, 1000 Welch Road #203, Palo Alto, California 94304, USA. E-mail: genovese@stanford.edu. Accepted for publication December 18, 2017.
Xiaohui Li
From Stanford University, Palo Alto, California; Arthritis Center of Nebraska, Lincoln, Nebraska; Box Arthritis and Rheumatology of the Carolinas, Charlotte, North Carolina; Low Country Rheumatology, Charleston, South Carolina; Bristol-Myers Squibb, Princeton, New Jersey, USA; Universidad Autónoma de Chihuahua, Chihuahua; Unidad Reumatológica Las Américas S.C.P., Mérida; Köhler & Milstein Research, Mérida, Mexico; Instituto De Ginecología Y Reproducción, Lima, Peru; Organización Médica de Investigación, Buenos Aires, Argentina; Pontifical Catholic University, Porto Alegre, Brazil; University of Queensland, Brisbane, Australia; Russian Academy of Medical Sciences, Moscow, Russia; Cliniques Universitaires Saint-Luc; Université Catholique de Louvain, Brussels, Belgium; Schlosspark-Klinik University Medicine, Berlin, Germany. This study was sponsored by Bristol-Myers Squibb. Dr. R.M. Valente received grant/research support from Novartis, Bristol- Myers Squibb, Pfizer, and Lilly. Dr. P. Nash received grant/research support, and speakers’ bureau and consulting fees from Bristol-Myers Squibb. Dr. C.W. Legerton received grant/research support from AbbVie, Ablynx, Acerta, Amgen, AstraZeneca, Celgene, GSK, Janssen, Lilly, Bristol-Myers Squibb, Pfizer, Novartis, Sandoz, UCB Pharma, Daiichi Sankyo, ChemoCentryx, and Boehringer Ingelheim, and speakers’ bureau fees from Celgene, Amgen, and Novartis. Dr. A. Elegbe, Dr. R. Wong, Dr. X. Li, and Dr. S. Banerjee are shareholders and employees of Bristol-Myers Squibb. M.C. Genovese, MD, Stanford University; C. Pacheco-Tena, MD, PhD, Universidad Autónoma de Chihuahua; A. Covarrubias, MD, Unidad Reumatológica Las Américas S.C.P.; G. Leon, MD, Instituto De Ginecología Y Reproducción; E. Mysler, MD, Organización Médica de Investigación; M. Keiserman, MD, Pontifical Catholic University; R.M. Valente, MD, Arthritis Center of Nebraska; P. Nash, MBBS (Hons), FRACP, University of Queensland; J.A. Simon-Campos, PhD, Köhler & Milstein Research; J. Box, MD, Box Arthritis and Rheumatology of the Carolinas; C.W. Legerton III, MD, Low Country Rheumatology; E. Nasonov, PhD, Russian Academy of Medical Sciences; P. Durez, MD, Cliniques Universitaires Saint-Luc, Université Catholique de Louvain; A. Elegbe, PhD, Bristol-Myers Squibb; R. Wong, MD, Bristol-Myers Squibb; X. Li, PhD, Bristol-Myers Squibb; S. Banerjee, MD, Bristol-Myers Squibb; R. Alten, MD, PhD, Schlosspark-Klinik University Medicine. Address correspondence to Dr. M.C. Genovese, Stanford University, Division of Immunology and Rheumatology, 1000 Welch Road #203, Palo Alto, California 94304, USA. E-mail: genovese@stanford.edu. Accepted for publication December 18, 2017.
Subhashis Banerjee
From Stanford University, Palo Alto, California; Arthritis Center of Nebraska, Lincoln, Nebraska; Box Arthritis and Rheumatology of the Carolinas, Charlotte, North Carolina; Low Country Rheumatology, Charleston, South Carolina; Bristol-Myers Squibb, Princeton, New Jersey, USA; Universidad Autónoma de Chihuahua, Chihuahua; Unidad Reumatológica Las Américas S.C.P., Mérida; Köhler & Milstein Research, Mérida, Mexico; Instituto De Ginecología Y Reproducción, Lima, Peru; Organización Médica de Investigación, Buenos Aires, Argentina; Pontifical Catholic University, Porto Alegre, Brazil; University of Queensland, Brisbane, Australia; Russian Academy of Medical Sciences, Moscow, Russia; Cliniques Universitaires Saint-Luc; Université Catholique de Louvain, Brussels, Belgium; Schlosspark-Klinik University Medicine, Berlin, Germany. This study was sponsored by Bristol-Myers Squibb. Dr. R.M. Valente received grant/research support from Novartis, Bristol- Myers Squibb, Pfizer, and Lilly. Dr. P. Nash received grant/research support, and speakers’ bureau and consulting fees from Bristol-Myers Squibb. Dr. C.W. Legerton received grant/research support from AbbVie, Ablynx, Acerta, Amgen, AstraZeneca, Celgene, GSK, Janssen, Lilly, Bristol-Myers Squibb, Pfizer, Novartis, Sandoz, UCB Pharma, Daiichi Sankyo, ChemoCentryx, and Boehringer Ingelheim, and speakers’ bureau fees from Celgene, Amgen, and Novartis. Dr. A. Elegbe, Dr. R. Wong, Dr. X. Li, and Dr. S. Banerjee are shareholders and employees of Bristol-Myers Squibb. M.C. Genovese, MD, Stanford University; C. Pacheco-Tena, MD, PhD, Universidad Autónoma de Chihuahua; A. Covarrubias, MD, Unidad Reumatológica Las Américas S.C.P.; G. Leon, MD, Instituto De Ginecología Y Reproducción; E. Mysler, MD, Organización Médica de Investigación; M. Keiserman, MD, Pontifical Catholic University; R.M. Valente, MD, Arthritis Center of Nebraska; P. Nash, MBBS (Hons), FRACP, University of Queensland; J.A. Simon-Campos, PhD, Köhler & Milstein Research; J. Box, MD, Box Arthritis and Rheumatology of the Carolinas; C.W. Legerton III, MD, Low Country Rheumatology; E. Nasonov, PhD, Russian Academy of Medical Sciences; P. Durez, MD, Cliniques Universitaires Saint-Luc, Université Catholique de Louvain; A. Elegbe, PhD, Bristol-Myers Squibb; R. Wong, MD, Bristol-Myers Squibb; X. Li, PhD, Bristol-Myers Squibb; S. Banerjee, MD, Bristol-Myers Squibb; R. Alten, MD, PhD, Schlosspark-Klinik University Medicine. Address correspondence to Dr. M.C. Genovese, Stanford University, Division of Immunology and Rheumatology, 1000 Welch Road #203, Palo Alto, California 94304, USA. E-mail: genovese@stanford.edu. Accepted for publication December 18, 2017.
Rieke Alten
From Stanford University, Palo Alto, California; Arthritis Center of Nebraska, Lincoln, Nebraska; Box Arthritis and Rheumatology of the Carolinas, Charlotte, North Carolina; Low Country Rheumatology, Charleston, South Carolina; Bristol-Myers Squibb, Princeton, New Jersey, USA; Universidad Autónoma de Chihuahua, Chihuahua; Unidad Reumatológica Las Américas S.C.P., Mérida; Köhler & Milstein Research, Mérida, Mexico; Instituto De Ginecología Y Reproducción, Lima, Peru; Organización Médica de Investigación, Buenos Aires, Argentina; Pontifical Catholic University, Porto Alegre, Brazil; University of Queensland, Brisbane, Australia; Russian Academy of Medical Sciences, Moscow, Russia; Cliniques Universitaires Saint-Luc; Université Catholique de Louvain, Brussels, Belgium; Schlosspark-Klinik University Medicine, Berlin, Germany. This study was sponsored by Bristol-Myers Squibb. Dr. R.M. Valente received grant/research support from Novartis, Bristol- Myers Squibb, Pfizer, and Lilly. Dr. P. Nash received grant/research support, and speakers’ bureau and consulting fees from Bristol-Myers Squibb. Dr. C.W. Legerton received grant/research support from AbbVie, Ablynx, Acerta, Amgen, AstraZeneca, Celgene, GSK, Janssen, Lilly, Bristol-Myers Squibb, Pfizer, Novartis, Sandoz, UCB Pharma, Daiichi Sankyo, ChemoCentryx, and Boehringer Ingelheim, and speakers’ bureau fees from Celgene, Amgen, and Novartis. Dr. A. Elegbe, Dr. R. Wong, Dr. X. Li, and Dr. S. Banerjee are shareholders and employees of Bristol-Myers Squibb. M.C. Genovese, MD, Stanford University; C. Pacheco-Tena, MD, PhD, Universidad Autónoma de Chihuahua; A. Covarrubias, MD, Unidad Reumatológica Las Américas S.C.P.; G. Leon, MD, Instituto De Ginecología Y Reproducción; E. Mysler, MD, Organización Médica de Investigación; M. Keiserman, MD, Pontifical Catholic University; R.M. Valente, MD, Arthritis Center of Nebraska; P. Nash, MBBS (Hons), FRACP, University of Queensland; J.A. Simon-Campos, PhD, Köhler & Milstein Research; J. Box, MD, Box Arthritis and Rheumatology of the Carolinas; C.W. Legerton III, MD, Low Country Rheumatology; E. Nasonov, PhD, Russian Academy of Medical Sciences; P. Durez, MD, Cliniques Universitaires Saint-Luc, Université Catholique de Louvain; A. Elegbe, PhD, Bristol-Myers Squibb; R. Wong, MD, Bristol-Myers Squibb; X. Li, PhD, Bristol-Myers Squibb; S. Banerjee, MD, Bristol-Myers Squibb; R. Alten, MD, PhD, Schlosspark-Klinik University Medicine. Address correspondence to Dr. M.C. Genovese, Stanford University, Division of Immunology and Rheumatology, 1000 Welch Road #203, Palo Alto, California 94304, USA. E-mail: genovese@stanford.edu. Accepted for publication December 18, 2017.
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The Journal of Rheumatology
Vol. 51, Issue 4
1 Apr 2024
Longterm Safety and Efficacy of Subcutaneous Abatacept in Patients with Rheumatoid Arthritis: 5-year Results from a Phase IIIb Trial
Mark C. Genovese, César Pacheco-Tena, Arturo Covarrubias, Gustavo Leon, Eduardo Mysler, Mauro Keiserman, Robert M. Valente, Peter Nash, J. Abraham Simon-Campos, Jane Box, Clarence W. Legerton, Evgeny Nasonov, Patrick Durez, Ayanbola Elegbe, Robert Wong, Xiaohui Li, Subhashis Banerjee, Rieke Alten
The Journal of Rheumatology Apr 2018, jrheum.170344; DOI: 10.3899/jrheum.170344
Longterm Safety and Efficacy of Subcutaneous Abatacept in Patients with Rheumatoid Arthritis: 5-year Results from a Phase IIIb Trial
Mark C. Genovese, César Pacheco-Tena, Arturo Covarrubias, Gustavo Leon, Eduardo Mysler, Mauro Keiserman, Robert M. Valente, Peter Nash, J. Abraham Simon-Campos, Jane Box, Clarence W. Legerton, Evgeny Nasonov, Patrick Durez, Ayanbola Elegbe, Robert Wong, Xiaohui Li, Subhashis Banerjee, Rieke Alten
The Journal of Rheumatology Apr 2018, jrheum.170344; DOI: 10.3899/jrheum.170344