Research ArticleArticle
Rituximab in the Treatment of Interstitial Lung Disease Associated with Antisynthetase Syndrome: A Multicenter Retrospective Case Review
Tracy J. Doyle, Namrata Dhillon, Rachna Madan, Fernanda Cabral, Elaine A. Fletcher, Diane C. Koontz, Rohit Aggarwal, Juan C. Osorio, Ivan O. Rosas, Chester V. Oddis and Paul F. Dellaripa
The Journal of Rheumatology April 2018, jrheum.170541; DOI: https://doi.org/10.3899/jrheum.170541
Tracy J. Doyle
From the Departments of Medicine and Radiology, Brigham and Women’s Hospital, Boston, Massachusetts; Departments of Medicine and Radiology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA. Supported by the US National Institutes of Health (grant number 1 K23 HL119558 to TJD). T.J. Doyle, MD, MPH, Pulmonary and Critical Care Division, Brigham and Women’s Hospital, Harvard Medical School; N. Dhillon, MD, Division of Rheumatology and Clinical Immunology, University of Pittsburgh School of Medicine; R. Madan, MD, Department of Radiology, Brigham and Women’s Hospital; F. Cabral, MD, Department of Radiology, Brigham and Women’s Hospital; E.A. Fletcher, Pulmonary and Critical Care Division, Brigham and Women’s Hospital, Harvard Medical School; D.C. Koontz, BS, Division of Rheumatology and Clinical Immunology, University of Pittsburgh School of Medicine; R. Aggarwal, MD, MS, Division of Rheumatology and Clinical Immunology, University of Pittsburgh School of Medicine; J.C. Osorio, MD, Pulmonary and Critical Care Division, Brigham and Women’s Hospital, Harvard Medical School; I.O. Rosas, MD, Pulmonary and Critical Care Division, Brigham and Women’s Hospital, Harvard Medical School; C.V. Oddis, MD, Division of Rheumatology and Clinical Immunology, University of Pittsburgh School of Medicine; P.F. Dellaripa, MD, Division of Rheumatology, Immunology and Allergy, Brigham and Women’s Hospital. Address correspondence to Dr. P.F. Dellaripa, Division of Rheumatology, Immunology and Allergy, Department of Medicine, Brigham and Women’s Hospital, Harvard Medical School, 75 Francis St., Boston, Massachusetts 02115, USA. E-mail: pdellaripa@partners.org. Accepted for publication November 15, 2017.
Namrata Dhillon
From the Departments of Medicine and Radiology, Brigham and Women’s Hospital, Boston, Massachusetts; Departments of Medicine and Radiology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA. Supported by the US National Institutes of Health (grant number 1 K23 HL119558 to TJD). T.J. Doyle, MD, MPH, Pulmonary and Critical Care Division, Brigham and Women’s Hospital, Harvard Medical School; N. Dhillon, MD, Division of Rheumatology and Clinical Immunology, University of Pittsburgh School of Medicine; R. Madan, MD, Department of Radiology, Brigham and Women’s Hospital; F. Cabral, MD, Department of Radiology, Brigham and Women’s Hospital; E.A. Fletcher, Pulmonary and Critical Care Division, Brigham and Women’s Hospital, Harvard Medical School; D.C. Koontz, BS, Division of Rheumatology and Clinical Immunology, University of Pittsburgh School of Medicine; R. Aggarwal, MD, MS, Division of Rheumatology and Clinical Immunology, University of Pittsburgh School of Medicine; J.C. Osorio, MD, Pulmonary and Critical Care Division, Brigham and Women’s Hospital, Harvard Medical School; I.O. Rosas, MD, Pulmonary and Critical Care Division, Brigham and Women’s Hospital, Harvard Medical School; C.V. Oddis, MD, Division of Rheumatology and Clinical Immunology, University of Pittsburgh School of Medicine; P.F. Dellaripa, MD, Division of Rheumatology, Immunology and Allergy, Brigham and Women’s Hospital. Address correspondence to Dr. P.F. Dellaripa, Division of Rheumatology, Immunology and Allergy, Department of Medicine, Brigham and Women’s Hospital, Harvard Medical School, 75 Francis St., Boston, Massachusetts 02115, USA. E-mail: pdellaripa@partners.org. Accepted for publication November 15, 2017.
Rachna Madan
From the Departments of Medicine and Radiology, Brigham and Women’s Hospital, Boston, Massachusetts; Departments of Medicine and Radiology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA. Supported by the US National Institutes of Health (grant number 1 K23 HL119558 to TJD). T.J. Doyle, MD, MPH, Pulmonary and Critical Care Division, Brigham and Women’s Hospital, Harvard Medical School; N. Dhillon, MD, Division of Rheumatology and Clinical Immunology, University of Pittsburgh School of Medicine; R. Madan, MD, Department of Radiology, Brigham and Women’s Hospital; F. Cabral, MD, Department of Radiology, Brigham and Women’s Hospital; E.A. Fletcher, Pulmonary and Critical Care Division, Brigham and Women’s Hospital, Harvard Medical School; D.C. Koontz, BS, Division of Rheumatology and Clinical Immunology, University of Pittsburgh School of Medicine; R. Aggarwal, MD, MS, Division of Rheumatology and Clinical Immunology, University of Pittsburgh School of Medicine; J.C. Osorio, MD, Pulmonary and Critical Care Division, Brigham and Women’s Hospital, Harvard Medical School; I.O. Rosas, MD, Pulmonary and Critical Care Division, Brigham and Women’s Hospital, Harvard Medical School; C.V. Oddis, MD, Division of Rheumatology and Clinical Immunology, University of Pittsburgh School of Medicine; P.F. Dellaripa, MD, Division of Rheumatology, Immunology and Allergy, Brigham and Women’s Hospital. Address correspondence to Dr. P.F. Dellaripa, Division of Rheumatology, Immunology and Allergy, Department of Medicine, Brigham and Women’s Hospital, Harvard Medical School, 75 Francis St., Boston, Massachusetts 02115, USA. E-mail: pdellaripa@partners.org. Accepted for publication November 15, 2017.
Fernanda Cabral
From the Departments of Medicine and Radiology, Brigham and Women’s Hospital, Boston, Massachusetts; Departments of Medicine and Radiology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA. Supported by the US National Institutes of Health (grant number 1 K23 HL119558 to TJD). T.J. Doyle, MD, MPH, Pulmonary and Critical Care Division, Brigham and Women’s Hospital, Harvard Medical School; N. Dhillon, MD, Division of Rheumatology and Clinical Immunology, University of Pittsburgh School of Medicine; R. Madan, MD, Department of Radiology, Brigham and Women’s Hospital; F. Cabral, MD, Department of Radiology, Brigham and Women’s Hospital; E.A. Fletcher, Pulmonary and Critical Care Division, Brigham and Women’s Hospital, Harvard Medical School; D.C. Koontz, BS, Division of Rheumatology and Clinical Immunology, University of Pittsburgh School of Medicine; R. Aggarwal, MD, MS, Division of Rheumatology and Clinical Immunology, University of Pittsburgh School of Medicine; J.C. Osorio, MD, Pulmonary and Critical Care Division, Brigham and Women’s Hospital, Harvard Medical School; I.O. Rosas, MD, Pulmonary and Critical Care Division, Brigham and Women’s Hospital, Harvard Medical School; C.V. Oddis, MD, Division of Rheumatology and Clinical Immunology, University of Pittsburgh School of Medicine; P.F. Dellaripa, MD, Division of Rheumatology, Immunology and Allergy, Brigham and Women’s Hospital. Address correspondence to Dr. P.F. Dellaripa, Division of Rheumatology, Immunology and Allergy, Department of Medicine, Brigham and Women’s Hospital, Harvard Medical School, 75 Francis St., Boston, Massachusetts 02115, USA. E-mail: pdellaripa@partners.org. Accepted for publication November 15, 2017.
Elaine A. Fletcher
From the Departments of Medicine and Radiology, Brigham and Women’s Hospital, Boston, Massachusetts; Departments of Medicine and Radiology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA. Supported by the US National Institutes of Health (grant number 1 K23 HL119558 to TJD). T.J. Doyle, MD, MPH, Pulmonary and Critical Care Division, Brigham and Women’s Hospital, Harvard Medical School; N. Dhillon, MD, Division of Rheumatology and Clinical Immunology, University of Pittsburgh School of Medicine; R. Madan, MD, Department of Radiology, Brigham and Women’s Hospital; F. Cabral, MD, Department of Radiology, Brigham and Women’s Hospital; E.A. Fletcher, Pulmonary and Critical Care Division, Brigham and Women’s Hospital, Harvard Medical School; D.C. Koontz, BS, Division of Rheumatology and Clinical Immunology, University of Pittsburgh School of Medicine; R. Aggarwal, MD, MS, Division of Rheumatology and Clinical Immunology, University of Pittsburgh School of Medicine; J.C. Osorio, MD, Pulmonary and Critical Care Division, Brigham and Women’s Hospital, Harvard Medical School; I.O. Rosas, MD, Pulmonary and Critical Care Division, Brigham and Women’s Hospital, Harvard Medical School; C.V. Oddis, MD, Division of Rheumatology and Clinical Immunology, University of Pittsburgh School of Medicine; P.F. Dellaripa, MD, Division of Rheumatology, Immunology and Allergy, Brigham and Women’s Hospital. Address correspondence to Dr. P.F. Dellaripa, Division of Rheumatology, Immunology and Allergy, Department of Medicine, Brigham and Women’s Hospital, Harvard Medical School, 75 Francis St., Boston, Massachusetts 02115, USA. E-mail: pdellaripa@partners.org. Accepted for publication November 15, 2017.
Diane C. Koontz
From the Departments of Medicine and Radiology, Brigham and Women’s Hospital, Boston, Massachusetts; Departments of Medicine and Radiology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA. Supported by the US National Institutes of Health (grant number 1 K23 HL119558 to TJD). T.J. Doyle, MD, MPH, Pulmonary and Critical Care Division, Brigham and Women’s Hospital, Harvard Medical School; N. Dhillon, MD, Division of Rheumatology and Clinical Immunology, University of Pittsburgh School of Medicine; R. Madan, MD, Department of Radiology, Brigham and Women’s Hospital; F. Cabral, MD, Department of Radiology, Brigham and Women’s Hospital; E.A. Fletcher, Pulmonary and Critical Care Division, Brigham and Women’s Hospital, Harvard Medical School; D.C. Koontz, BS, Division of Rheumatology and Clinical Immunology, University of Pittsburgh School of Medicine; R. Aggarwal, MD, MS, Division of Rheumatology and Clinical Immunology, University of Pittsburgh School of Medicine; J.C. Osorio, MD, Pulmonary and Critical Care Division, Brigham and Women’s Hospital, Harvard Medical School; I.O. Rosas, MD, Pulmonary and Critical Care Division, Brigham and Women’s Hospital, Harvard Medical School; C.V. Oddis, MD, Division of Rheumatology and Clinical Immunology, University of Pittsburgh School of Medicine; P.F. Dellaripa, MD, Division of Rheumatology, Immunology and Allergy, Brigham and Women’s Hospital. Address correspondence to Dr. P.F. Dellaripa, Division of Rheumatology, Immunology and Allergy, Department of Medicine, Brigham and Women’s Hospital, Harvard Medical School, 75 Francis St., Boston, Massachusetts 02115, USA. E-mail: pdellaripa@partners.org. Accepted for publication November 15, 2017.
Rohit Aggarwal
From the Departments of Medicine and Radiology, Brigham and Women’s Hospital, Boston, Massachusetts; Departments of Medicine and Radiology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA. Supported by the US National Institutes of Health (grant number 1 K23 HL119558 to TJD). T.J. Doyle, MD, MPH, Pulmonary and Critical Care Division, Brigham and Women’s Hospital, Harvard Medical School; N. Dhillon, MD, Division of Rheumatology and Clinical Immunology, University of Pittsburgh School of Medicine; R. Madan, MD, Department of Radiology, Brigham and Women’s Hospital; F. Cabral, MD, Department of Radiology, Brigham and Women’s Hospital; E.A. Fletcher, Pulmonary and Critical Care Division, Brigham and Women’s Hospital, Harvard Medical School; D.C. Koontz, BS, Division of Rheumatology and Clinical Immunology, University of Pittsburgh School of Medicine; R. Aggarwal, MD, MS, Division of Rheumatology and Clinical Immunology, University of Pittsburgh School of Medicine; J.C. Osorio, MD, Pulmonary and Critical Care Division, Brigham and Women’s Hospital, Harvard Medical School; I.O. Rosas, MD, Pulmonary and Critical Care Division, Brigham and Women’s Hospital, Harvard Medical School; C.V. Oddis, MD, Division of Rheumatology and Clinical Immunology, University of Pittsburgh School of Medicine; P.F. Dellaripa, MD, Division of Rheumatology, Immunology and Allergy, Brigham and Women’s Hospital. Address correspondence to Dr. P.F. Dellaripa, Division of Rheumatology, Immunology and Allergy, Department of Medicine, Brigham and Women’s Hospital, Harvard Medical School, 75 Francis St., Boston, Massachusetts 02115, USA. E-mail: pdellaripa@partners.org. Accepted for publication November 15, 2017.
Juan C. Osorio
From the Departments of Medicine and Radiology, Brigham and Women’s Hospital, Boston, Massachusetts; Departments of Medicine and Radiology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA. Supported by the US National Institutes of Health (grant number 1 K23 HL119558 to TJD). T.J. Doyle, MD, MPH, Pulmonary and Critical Care Division, Brigham and Women’s Hospital, Harvard Medical School; N. Dhillon, MD, Division of Rheumatology and Clinical Immunology, University of Pittsburgh School of Medicine; R. Madan, MD, Department of Radiology, Brigham and Women’s Hospital; F. Cabral, MD, Department of Radiology, Brigham and Women’s Hospital; E.A. Fletcher, Pulmonary and Critical Care Division, Brigham and Women’s Hospital, Harvard Medical School; D.C. Koontz, BS, Division of Rheumatology and Clinical Immunology, University of Pittsburgh School of Medicine; R. Aggarwal, MD, MS, Division of Rheumatology and Clinical Immunology, University of Pittsburgh School of Medicine; J.C. Osorio, MD, Pulmonary and Critical Care Division, Brigham and Women’s Hospital, Harvard Medical School; I.O. Rosas, MD, Pulmonary and Critical Care Division, Brigham and Women’s Hospital, Harvard Medical School; C.V. Oddis, MD, Division of Rheumatology and Clinical Immunology, University of Pittsburgh School of Medicine; P.F. Dellaripa, MD, Division of Rheumatology, Immunology and Allergy, Brigham and Women’s Hospital. Address correspondence to Dr. P.F. Dellaripa, Division of Rheumatology, Immunology and Allergy, Department of Medicine, Brigham and Women’s Hospital, Harvard Medical School, 75 Francis St., Boston, Massachusetts 02115, USA. E-mail: pdellaripa@partners.org. Accepted for publication November 15, 2017.
Ivan O. Rosas
From the Departments of Medicine and Radiology, Brigham and Women’s Hospital, Boston, Massachusetts; Departments of Medicine and Radiology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA. Supported by the US National Institutes of Health (grant number 1 K23 HL119558 to TJD). T.J. Doyle, MD, MPH, Pulmonary and Critical Care Division, Brigham and Women’s Hospital, Harvard Medical School; N. Dhillon, MD, Division of Rheumatology and Clinical Immunology, University of Pittsburgh School of Medicine; R. Madan, MD, Department of Radiology, Brigham and Women’s Hospital; F. Cabral, MD, Department of Radiology, Brigham and Women’s Hospital; E.A. Fletcher, Pulmonary and Critical Care Division, Brigham and Women’s Hospital, Harvard Medical School; D.C. Koontz, BS, Division of Rheumatology and Clinical Immunology, University of Pittsburgh School of Medicine; R. Aggarwal, MD, MS, Division of Rheumatology and Clinical Immunology, University of Pittsburgh School of Medicine; J.C. Osorio, MD, Pulmonary and Critical Care Division, Brigham and Women’s Hospital, Harvard Medical School; I.O. Rosas, MD, Pulmonary and Critical Care Division, Brigham and Women’s Hospital, Harvard Medical School; C.V. Oddis, MD, Division of Rheumatology and Clinical Immunology, University of Pittsburgh School of Medicine; P.F. Dellaripa, MD, Division of Rheumatology, Immunology and Allergy, Brigham and Women’s Hospital. Address correspondence to Dr. P.F. Dellaripa, Division of Rheumatology, Immunology and Allergy, Department of Medicine, Brigham and Women’s Hospital, Harvard Medical School, 75 Francis St., Boston, Massachusetts 02115, USA. E-mail: pdellaripa@partners.org. Accepted for publication November 15, 2017.
Chester V. Oddis
From the Departments of Medicine and Radiology, Brigham and Women’s Hospital, Boston, Massachusetts; Departments of Medicine and Radiology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA. Supported by the US National Institutes of Health (grant number 1 K23 HL119558 to TJD). T.J. Doyle, MD, MPH, Pulmonary and Critical Care Division, Brigham and Women’s Hospital, Harvard Medical School; N. Dhillon, MD, Division of Rheumatology and Clinical Immunology, University of Pittsburgh School of Medicine; R. Madan, MD, Department of Radiology, Brigham and Women’s Hospital; F. Cabral, MD, Department of Radiology, Brigham and Women’s Hospital; E.A. Fletcher, Pulmonary and Critical Care Division, Brigham and Women’s Hospital, Harvard Medical School; D.C. Koontz, BS, Division of Rheumatology and Clinical Immunology, University of Pittsburgh School of Medicine; R. Aggarwal, MD, MS, Division of Rheumatology and Clinical Immunology, University of Pittsburgh School of Medicine; J.C. Osorio, MD, Pulmonary and Critical Care Division, Brigham and Women’s Hospital, Harvard Medical School; I.O. Rosas, MD, Pulmonary and Critical Care Division, Brigham and Women’s Hospital, Harvard Medical School; C.V. Oddis, MD, Division of Rheumatology and Clinical Immunology, University of Pittsburgh School of Medicine; P.F. Dellaripa, MD, Division of Rheumatology, Immunology and Allergy, Brigham and Women’s Hospital. Address correspondence to Dr. P.F. Dellaripa, Division of Rheumatology, Immunology and Allergy, Department of Medicine, Brigham and Women’s Hospital, Harvard Medical School, 75 Francis St., Boston, Massachusetts 02115, USA. E-mail: pdellaripa@partners.org. Accepted for publication November 15, 2017.
Paul F. Dellaripa
From the Departments of Medicine and Radiology, Brigham and Women’s Hospital, Boston, Massachusetts; Departments of Medicine and Radiology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA. Supported by the US National Institutes of Health (grant number 1 K23 HL119558 to TJD). T.J. Doyle, MD, MPH, Pulmonary and Critical Care Division, Brigham and Women’s Hospital, Harvard Medical School; N. Dhillon, MD, Division of Rheumatology and Clinical Immunology, University of Pittsburgh School of Medicine; R. Madan, MD, Department of Radiology, Brigham and Women’s Hospital; F. Cabral, MD, Department of Radiology, Brigham and Women’s Hospital; E.A. Fletcher, Pulmonary and Critical Care Division, Brigham and Women’s Hospital, Harvard Medical School; D.C. Koontz, BS, Division of Rheumatology and Clinical Immunology, University of Pittsburgh School of Medicine; R. Aggarwal, MD, MS, Division of Rheumatology and Clinical Immunology, University of Pittsburgh School of Medicine; J.C. Osorio, MD, Pulmonary and Critical Care Division, Brigham and Women’s Hospital, Harvard Medical School; I.O. Rosas, MD, Pulmonary and Critical Care Division, Brigham and Women’s Hospital, Harvard Medical School; C.V. Oddis, MD, Division of Rheumatology and Clinical Immunology, University of Pittsburgh School of Medicine; P.F. Dellaripa, MD, Division of Rheumatology, Immunology and Allergy, Brigham and Women’s Hospital. Address correspondence to Dr. P.F. Dellaripa, Division of Rheumatology, Immunology and Allergy, Department of Medicine, Brigham and Women’s Hospital, Harvard Medical School, 75 Francis St., Boston, Massachusetts 02115, USA. E-mail: pdellaripa@partners.org. Accepted for publication November 15, 2017.
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- Published online April 1, 2018.
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© 2018 The Journal of Rheumatology
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- Tracy J. Doyle,
- Namrata Dhillon,
- Rachna Madan,
- Fernanda Cabral,
- Elaine A. Fletcher,
- Diane C. Koontz,
- Rohit Aggarwal,
- Juan C. Osorio,
- Ivan O. Rosas,
- Chester V. Oddis and
- Paul F. Dellaripa
- From the Departments of Medicine and Radiology, Brigham and Women’s Hospital, Boston, Massachusetts; Departments of Medicine and Radiology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA.
Supported by the US National Institutes of Health (grant number 1 K23 HL119558 to TJD).
T.J. Doyle, MD, MPH, Pulmonary and Critical Care Division, Brigham and Women’s Hospital, Harvard Medical School; N. Dhillon, MD, Division of Rheumatology and Clinical Immunology, University of Pittsburgh School of Medicine; R. Madan, MD, Department of Radiology, Brigham and Women’s Hospital; F. Cabral, MD, Department of Radiology, Brigham and Women’s Hospital; E.A. Fletcher, Pulmonary and Critical Care Division, Brigham and Women’s Hospital, Harvard Medical School; D.C. Koontz, BS, Division of Rheumatology and Clinical Immunology, University of Pittsburgh School of Medicine; R. Aggarwal, MD, MS, Division of Rheumatology and Clinical Immunology, University of Pittsburgh School of Medicine; J.C. Osorio, MD, Pulmonary and Critical Care Division, Brigham and Women’s Hospital, Harvard Medical School; I.O. Rosas, MD, Pulmonary and Critical Care Division, Brigham and Women’s Hospital, Harvard Medical School; C.V. Oddis, MD, Division of Rheumatology and Clinical Immunology, University of Pittsburgh School of Medicine; P.F. Dellaripa, MD, Division of Rheumatology, Immunology and Allergy, Brigham and Women’s Hospital.
Address correspondence to Dr. P.F. Dellaripa, Division of Rheumatology, Immunology and Allergy, Department of Medicine, Brigham and Women’s Hospital, Harvard Medical School, 75 Francis St., Boston, Massachusetts 02115, USA. E-mail: pdellaripa@partners.org.
Accepted for publication November 15, 2017.
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The Journal of Rheumatology
Vol. 51, Issue 4
1 Apr 2024
Rituximab in the Treatment of Interstitial Lung Disease Associated with Antisynthetase Syndrome: A Multicenter Retrospective Case Review
Tracy J. Doyle, Namrata Dhillon, Rachna Madan, Fernanda Cabral, Elaine A. Fletcher, Diane C. Koontz, Rohit Aggarwal, Juan C. Osorio, Ivan O. Rosas, Chester V. Oddis, Paul F. Dellaripa
The Journal of Rheumatology Apr 2018, jrheum.170541; DOI: 10.3899/jrheum.170541
Rituximab in the Treatment of Interstitial Lung Disease Associated with Antisynthetase Syndrome: A Multicenter Retrospective Case Review
Tracy J. Doyle, Namrata Dhillon, Rachna Madan, Fernanda Cabral, Elaine A. Fletcher, Diane C. Koontz, Rohit Aggarwal, Juan C. Osorio, Ivan O. Rosas, Chester V. Oddis, Paul F. Dellaripa
The Journal of Rheumatology Apr 2018, jrheum.170541; DOI: 10.3899/jrheum.170541