Research ArticleArticle
Whole-body Magnetic Resonance Imaging in Axial Spondyloarthritis: Reduction of Sacroiliac, Spinal, and Entheseal Inflammation in a Placebo-controlled Trial of Adalimumab
Simon Krabbe, Mikkel Østergaard, Iris Eshed, Inge J. Sørensen, Bente Jensen, Jakob M. Møller, Lone Balding, Ole R. Madsen, Karsten Asmussen, Grith Eng, Niklas R. Jørgensen and Susanne J. Pedersen
The Journal of Rheumatology February 2018, jrheum.170408; DOI: https://doi.org/10.3899/jrheum.170408
Simon Krabbe
From the Copenhagen Center for Arthritis Research, Center for Rheumatology and Spine Diseases, and Department of Clinical Biochemistry, Rigshospitalet, Glostrup; Department of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen; Center for Rheumatology and Spine Diseases, Frederiksberg Hospital, Frederiksberg; Department of Radiology, Copenhagen University Hospital Herlev, Herlev; Center for Rheumatology and Spine Diseases, Copenhagen University Hospital Gentofte, Hellerup; Department of Rheumatology, Zealand University Hospital, Køge; Odense Patient Data Explorative Network (OPEN), Odense University Hospital/Institute of Clinical Research, Odense, Denmark; Department of Diagnostic Imaging, Sheba Medical Center (affiliated with the Sackler School of Medicine, Tel Aviv University), Ramat Gan, Israel. The work was supported by AbbVie. AbbVie had no role in the study design or in the collection, analysis, or interpretation of the data, the writing of the manuscript, or the decision to submit the manuscript for publication; publication of this article was not contingent upon approval by AbbVie. SK had a grant from The Danish Rheumatism Association (A3866). S. Krabbe, MD, Copenhagen Center for Arthritis Research, Center for Rheumatology and Spine Diseases, Rigshospitalet, and Department of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen; M. Østergaard, MD, PhD, DMSc, Copenhagen Center for Arthritis Research, Center for Rheumatology and Spine Diseases, Rigshospitalet, and Department of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen; I. Eshed, MD, Department of Diagnostic Imaging, Sheba Medical Center; I.J. Sørensen, MD, PhD, Copenhagen Center for Arthritis Research, Center for Rheumatology and Spine Diseases, Rigshospitalet, and Department of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen; B. Jensen, MD, Center for Rheumatology and Spine Diseases, Frederiksberg Hospital; J.M. Møller, Radiographer, Department of Radiology, Copenhagen University Hospital Herlev; L. Balding, MD, Department of Radiology, Copenhagen University Hospital Herlev; O.R. Madsen, MD, PhD, DMSc, Center for Rheumatology and Spine Diseases, Copenhagen University Hospital Gentofte; K. Asmussen, MD, PhD, Center for Rheumatology and Spine Diseases, Frederiksberg Hospital; G. Eng, MD, PhD, Department of Rheumatology, Zealand University Hospital Køge; N.R. Jørgensen, MD, PhD, DMSc, Department of Clinical Biochemistry, Rigshospitalet, and OPEN, Odense University Hospital/Institute of Clinical Research; S.J. Pedersen, MD, PhD, Copenhagen Center for Arthritis Research, Center for Rheumatology and Spine Diseases, Rigshospitalet, and Center for Rheumatology and Spine Diseases, Copenhagen University Hospital Gentofte. Address correspondence to Dr. S. Krabbe, Copenhagen Center for Arthritis Research, Center for Rheumatology and Spine Diseases, Rigshospitalet, Glostrup, Valdemar Hansens Vej 17, DK-2600 Glostrup, Denmark. E-mail: simonkrabbe@gmail.com. Accepted for publication November 17, 2017.
Mikkel Østergaard
From the Copenhagen Center for Arthritis Research, Center for Rheumatology and Spine Diseases, and Department of Clinical Biochemistry, Rigshospitalet, Glostrup; Department of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen; Center for Rheumatology and Spine Diseases, Frederiksberg Hospital, Frederiksberg; Department of Radiology, Copenhagen University Hospital Herlev, Herlev; Center for Rheumatology and Spine Diseases, Copenhagen University Hospital Gentofte, Hellerup; Department of Rheumatology, Zealand University Hospital, Køge; Odense Patient Data Explorative Network (OPEN), Odense University Hospital/Institute of Clinical Research, Odense, Denmark; Department of Diagnostic Imaging, Sheba Medical Center (affiliated with the Sackler School of Medicine, Tel Aviv University), Ramat Gan, Israel. The work was supported by AbbVie. AbbVie had no role in the study design or in the collection, analysis, or interpretation of the data, the writing of the manuscript, or the decision to submit the manuscript for publication; publication of this article was not contingent upon approval by AbbVie. SK had a grant from The Danish Rheumatism Association (A3866). S. Krabbe, MD, Copenhagen Center for Arthritis Research, Center for Rheumatology and Spine Diseases, Rigshospitalet, and Department of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen; M. Østergaard, MD, PhD, DMSc, Copenhagen Center for Arthritis Research, Center for Rheumatology and Spine Diseases, Rigshospitalet, and Department of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen; I. Eshed, MD, Department of Diagnostic Imaging, Sheba Medical Center; I.J. Sørensen, MD, PhD, Copenhagen Center for Arthritis Research, Center for Rheumatology and Spine Diseases, Rigshospitalet, and Department of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen; B. Jensen, MD, Center for Rheumatology and Spine Diseases, Frederiksberg Hospital; J.M. Møller, Radiographer, Department of Radiology, Copenhagen University Hospital Herlev; L. Balding, MD, Department of Radiology, Copenhagen University Hospital Herlev; O.R. Madsen, MD, PhD, DMSc, Center for Rheumatology and Spine Diseases, Copenhagen University Hospital Gentofte; K. Asmussen, MD, PhD, Center for Rheumatology and Spine Diseases, Frederiksberg Hospital; G. Eng, MD, PhD, Department of Rheumatology, Zealand University Hospital Køge; N.R. Jørgensen, MD, PhD, DMSc, Department of Clinical Biochemistry, Rigshospitalet, and OPEN, Odense University Hospital/Institute of Clinical Research; S.J. Pedersen, MD, PhD, Copenhagen Center for Arthritis Research, Center for Rheumatology and Spine Diseases, Rigshospitalet, and Center for Rheumatology and Spine Diseases, Copenhagen University Hospital Gentofte. Address correspondence to Dr. S. Krabbe, Copenhagen Center for Arthritis Research, Center for Rheumatology and Spine Diseases, Rigshospitalet, Glostrup, Valdemar Hansens Vej 17, DK-2600 Glostrup, Denmark. E-mail: simonkrabbe@gmail.com. Accepted for publication November 17, 2017.
Iris Eshed
From the Copenhagen Center for Arthritis Research, Center for Rheumatology and Spine Diseases, and Department of Clinical Biochemistry, Rigshospitalet, Glostrup; Department of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen; Center for Rheumatology and Spine Diseases, Frederiksberg Hospital, Frederiksberg; Department of Radiology, Copenhagen University Hospital Herlev, Herlev; Center for Rheumatology and Spine Diseases, Copenhagen University Hospital Gentofte, Hellerup; Department of Rheumatology, Zealand University Hospital, Køge; Odense Patient Data Explorative Network (OPEN), Odense University Hospital/Institute of Clinical Research, Odense, Denmark; Department of Diagnostic Imaging, Sheba Medical Center (affiliated with the Sackler School of Medicine, Tel Aviv University), Ramat Gan, Israel. The work was supported by AbbVie. AbbVie had no role in the study design or in the collection, analysis, or interpretation of the data, the writing of the manuscript, or the decision to submit the manuscript for publication; publication of this article was not contingent upon approval by AbbVie. SK had a grant from The Danish Rheumatism Association (A3866). S. Krabbe, MD, Copenhagen Center for Arthritis Research, Center for Rheumatology and Spine Diseases, Rigshospitalet, and Department of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen; M. Østergaard, MD, PhD, DMSc, Copenhagen Center for Arthritis Research, Center for Rheumatology and Spine Diseases, Rigshospitalet, and Department of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen; I. Eshed, MD, Department of Diagnostic Imaging, Sheba Medical Center; I.J. Sørensen, MD, PhD, Copenhagen Center for Arthritis Research, Center for Rheumatology and Spine Diseases, Rigshospitalet, and Department of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen; B. Jensen, MD, Center for Rheumatology and Spine Diseases, Frederiksberg Hospital; J.M. Møller, Radiographer, Department of Radiology, Copenhagen University Hospital Herlev; L. Balding, MD, Department of Radiology, Copenhagen University Hospital Herlev; O.R. Madsen, MD, PhD, DMSc, Center for Rheumatology and Spine Diseases, Copenhagen University Hospital Gentofte; K. Asmussen, MD, PhD, Center for Rheumatology and Spine Diseases, Frederiksberg Hospital; G. Eng, MD, PhD, Department of Rheumatology, Zealand University Hospital Køge; N.R. Jørgensen, MD, PhD, DMSc, Department of Clinical Biochemistry, Rigshospitalet, and OPEN, Odense University Hospital/Institute of Clinical Research; S.J. Pedersen, MD, PhD, Copenhagen Center for Arthritis Research, Center for Rheumatology and Spine Diseases, Rigshospitalet, and Center for Rheumatology and Spine Diseases, Copenhagen University Hospital Gentofte. Address correspondence to Dr. S. Krabbe, Copenhagen Center for Arthritis Research, Center for Rheumatology and Spine Diseases, Rigshospitalet, Glostrup, Valdemar Hansens Vej 17, DK-2600 Glostrup, Denmark. E-mail: simonkrabbe@gmail.com. Accepted for publication November 17, 2017.
Inge J. Sørensen
From the Copenhagen Center for Arthritis Research, Center for Rheumatology and Spine Diseases, and Department of Clinical Biochemistry, Rigshospitalet, Glostrup; Department of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen; Center for Rheumatology and Spine Diseases, Frederiksberg Hospital, Frederiksberg; Department of Radiology, Copenhagen University Hospital Herlev, Herlev; Center for Rheumatology and Spine Diseases, Copenhagen University Hospital Gentofte, Hellerup; Department of Rheumatology, Zealand University Hospital, Køge; Odense Patient Data Explorative Network (OPEN), Odense University Hospital/Institute of Clinical Research, Odense, Denmark; Department of Diagnostic Imaging, Sheba Medical Center (affiliated with the Sackler School of Medicine, Tel Aviv University), Ramat Gan, Israel. The work was supported by AbbVie. AbbVie had no role in the study design or in the collection, analysis, or interpretation of the data, the writing of the manuscript, or the decision to submit the manuscript for publication; publication of this article was not contingent upon approval by AbbVie. SK had a grant from The Danish Rheumatism Association (A3866). S. Krabbe, MD, Copenhagen Center for Arthritis Research, Center for Rheumatology and Spine Diseases, Rigshospitalet, and Department of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen; M. Østergaard, MD, PhD, DMSc, Copenhagen Center for Arthritis Research, Center for Rheumatology and Spine Diseases, Rigshospitalet, and Department of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen; I. Eshed, MD, Department of Diagnostic Imaging, Sheba Medical Center; I.J. Sørensen, MD, PhD, Copenhagen Center for Arthritis Research, Center for Rheumatology and Spine Diseases, Rigshospitalet, and Department of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen; B. Jensen, MD, Center for Rheumatology and Spine Diseases, Frederiksberg Hospital; J.M. Møller, Radiographer, Department of Radiology, Copenhagen University Hospital Herlev; L. Balding, MD, Department of Radiology, Copenhagen University Hospital Herlev; O.R. Madsen, MD, PhD, DMSc, Center for Rheumatology and Spine Diseases, Copenhagen University Hospital Gentofte; K. Asmussen, MD, PhD, Center for Rheumatology and Spine Diseases, Frederiksberg Hospital; G. Eng, MD, PhD, Department of Rheumatology, Zealand University Hospital Køge; N.R. Jørgensen, MD, PhD, DMSc, Department of Clinical Biochemistry, Rigshospitalet, and OPEN, Odense University Hospital/Institute of Clinical Research; S.J. Pedersen, MD, PhD, Copenhagen Center for Arthritis Research, Center for Rheumatology and Spine Diseases, Rigshospitalet, and Center for Rheumatology and Spine Diseases, Copenhagen University Hospital Gentofte. Address correspondence to Dr. S. Krabbe, Copenhagen Center for Arthritis Research, Center for Rheumatology and Spine Diseases, Rigshospitalet, Glostrup, Valdemar Hansens Vej 17, DK-2600 Glostrup, Denmark. E-mail: simonkrabbe@gmail.com. Accepted for publication November 17, 2017.
Bente Jensen
From the Copenhagen Center for Arthritis Research, Center for Rheumatology and Spine Diseases, and Department of Clinical Biochemistry, Rigshospitalet, Glostrup; Department of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen; Center for Rheumatology and Spine Diseases, Frederiksberg Hospital, Frederiksberg; Department of Radiology, Copenhagen University Hospital Herlev, Herlev; Center for Rheumatology and Spine Diseases, Copenhagen University Hospital Gentofte, Hellerup; Department of Rheumatology, Zealand University Hospital, Køge; Odense Patient Data Explorative Network (OPEN), Odense University Hospital/Institute of Clinical Research, Odense, Denmark; Department of Diagnostic Imaging, Sheba Medical Center (affiliated with the Sackler School of Medicine, Tel Aviv University), Ramat Gan, Israel. The work was supported by AbbVie. AbbVie had no role in the study design or in the collection, analysis, or interpretation of the data, the writing of the manuscript, or the decision to submit the manuscript for publication; publication of this article was not contingent upon approval by AbbVie. SK had a grant from The Danish Rheumatism Association (A3866). S. Krabbe, MD, Copenhagen Center for Arthritis Research, Center for Rheumatology and Spine Diseases, Rigshospitalet, and Department of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen; M. Østergaard, MD, PhD, DMSc, Copenhagen Center for Arthritis Research, Center for Rheumatology and Spine Diseases, Rigshospitalet, and Department of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen; I. Eshed, MD, Department of Diagnostic Imaging, Sheba Medical Center; I.J. Sørensen, MD, PhD, Copenhagen Center for Arthritis Research, Center for Rheumatology and Spine Diseases, Rigshospitalet, and Department of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen; B. Jensen, MD, Center for Rheumatology and Spine Diseases, Frederiksberg Hospital; J.M. Møller, Radiographer, Department of Radiology, Copenhagen University Hospital Herlev; L. Balding, MD, Department of Radiology, Copenhagen University Hospital Herlev; O.R. Madsen, MD, PhD, DMSc, Center for Rheumatology and Spine Diseases, Copenhagen University Hospital Gentofte; K. Asmussen, MD, PhD, Center for Rheumatology and Spine Diseases, Frederiksberg Hospital; G. Eng, MD, PhD, Department of Rheumatology, Zealand University Hospital Køge; N.R. Jørgensen, MD, PhD, DMSc, Department of Clinical Biochemistry, Rigshospitalet, and OPEN, Odense University Hospital/Institute of Clinical Research; S.J. Pedersen, MD, PhD, Copenhagen Center for Arthritis Research, Center for Rheumatology and Spine Diseases, Rigshospitalet, and Center for Rheumatology and Spine Diseases, Copenhagen University Hospital Gentofte. Address correspondence to Dr. S. Krabbe, Copenhagen Center for Arthritis Research, Center for Rheumatology and Spine Diseases, Rigshospitalet, Glostrup, Valdemar Hansens Vej 17, DK-2600 Glostrup, Denmark. E-mail: simonkrabbe@gmail.com. Accepted for publication November 17, 2017.
Jakob M. Møller
From the Copenhagen Center for Arthritis Research, Center for Rheumatology and Spine Diseases, and Department of Clinical Biochemistry, Rigshospitalet, Glostrup; Department of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen; Center for Rheumatology and Spine Diseases, Frederiksberg Hospital, Frederiksberg; Department of Radiology, Copenhagen University Hospital Herlev, Herlev; Center for Rheumatology and Spine Diseases, Copenhagen University Hospital Gentofte, Hellerup; Department of Rheumatology, Zealand University Hospital, Køge; Odense Patient Data Explorative Network (OPEN), Odense University Hospital/Institute of Clinical Research, Odense, Denmark; Department of Diagnostic Imaging, Sheba Medical Center (affiliated with the Sackler School of Medicine, Tel Aviv University), Ramat Gan, Israel. The work was supported by AbbVie. AbbVie had no role in the study design or in the collection, analysis, or interpretation of the data, the writing of the manuscript, or the decision to submit the manuscript for publication; publication of this article was not contingent upon approval by AbbVie. SK had a grant from The Danish Rheumatism Association (A3866). S. Krabbe, MD, Copenhagen Center for Arthritis Research, Center for Rheumatology and Spine Diseases, Rigshospitalet, and Department of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen; M. Østergaard, MD, PhD, DMSc, Copenhagen Center for Arthritis Research, Center for Rheumatology and Spine Diseases, Rigshospitalet, and Department of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen; I. Eshed, MD, Department of Diagnostic Imaging, Sheba Medical Center; I.J. Sørensen, MD, PhD, Copenhagen Center for Arthritis Research, Center for Rheumatology and Spine Diseases, Rigshospitalet, and Department of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen; B. Jensen, MD, Center for Rheumatology and Spine Diseases, Frederiksberg Hospital; J.M. Møller, Radiographer, Department of Radiology, Copenhagen University Hospital Herlev; L. Balding, MD, Department of Radiology, Copenhagen University Hospital Herlev; O.R. Madsen, MD, PhD, DMSc, Center for Rheumatology and Spine Diseases, Copenhagen University Hospital Gentofte; K. Asmussen, MD, PhD, Center for Rheumatology and Spine Diseases, Frederiksberg Hospital; G. Eng, MD, PhD, Department of Rheumatology, Zealand University Hospital Køge; N.R. Jørgensen, MD, PhD, DMSc, Department of Clinical Biochemistry, Rigshospitalet, and OPEN, Odense University Hospital/Institute of Clinical Research; S.J. Pedersen, MD, PhD, Copenhagen Center for Arthritis Research, Center for Rheumatology and Spine Diseases, Rigshospitalet, and Center for Rheumatology and Spine Diseases, Copenhagen University Hospital Gentofte. Address correspondence to Dr. S. Krabbe, Copenhagen Center for Arthritis Research, Center for Rheumatology and Spine Diseases, Rigshospitalet, Glostrup, Valdemar Hansens Vej 17, DK-2600 Glostrup, Denmark. E-mail: simonkrabbe@gmail.com. Accepted for publication November 17, 2017.
Lone Balding
From the Copenhagen Center for Arthritis Research, Center for Rheumatology and Spine Diseases, and Department of Clinical Biochemistry, Rigshospitalet, Glostrup; Department of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen; Center for Rheumatology and Spine Diseases, Frederiksberg Hospital, Frederiksberg; Department of Radiology, Copenhagen University Hospital Herlev, Herlev; Center for Rheumatology and Spine Diseases, Copenhagen University Hospital Gentofte, Hellerup; Department of Rheumatology, Zealand University Hospital, Køge; Odense Patient Data Explorative Network (OPEN), Odense University Hospital/Institute of Clinical Research, Odense, Denmark; Department of Diagnostic Imaging, Sheba Medical Center (affiliated with the Sackler School of Medicine, Tel Aviv University), Ramat Gan, Israel. The work was supported by AbbVie. AbbVie had no role in the study design or in the collection, analysis, or interpretation of the data, the writing of the manuscript, or the decision to submit the manuscript for publication; publication of this article was not contingent upon approval by AbbVie. SK had a grant from The Danish Rheumatism Association (A3866). S. Krabbe, MD, Copenhagen Center for Arthritis Research, Center for Rheumatology and Spine Diseases, Rigshospitalet, and Department of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen; M. Østergaard, MD, PhD, DMSc, Copenhagen Center for Arthritis Research, Center for Rheumatology and Spine Diseases, Rigshospitalet, and Department of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen; I. Eshed, MD, Department of Diagnostic Imaging, Sheba Medical Center; I.J. Sørensen, MD, PhD, Copenhagen Center for Arthritis Research, Center for Rheumatology and Spine Diseases, Rigshospitalet, and Department of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen; B. Jensen, MD, Center for Rheumatology and Spine Diseases, Frederiksberg Hospital; J.M. Møller, Radiographer, Department of Radiology, Copenhagen University Hospital Herlev; L. Balding, MD, Department of Radiology, Copenhagen University Hospital Herlev; O.R. Madsen, MD, PhD, DMSc, Center for Rheumatology and Spine Diseases, Copenhagen University Hospital Gentofte; K. Asmussen, MD, PhD, Center for Rheumatology and Spine Diseases, Frederiksberg Hospital; G. Eng, MD, PhD, Department of Rheumatology, Zealand University Hospital Køge; N.R. Jørgensen, MD, PhD, DMSc, Department of Clinical Biochemistry, Rigshospitalet, and OPEN, Odense University Hospital/Institute of Clinical Research; S.J. Pedersen, MD, PhD, Copenhagen Center for Arthritis Research, Center for Rheumatology and Spine Diseases, Rigshospitalet, and Center for Rheumatology and Spine Diseases, Copenhagen University Hospital Gentofte. Address correspondence to Dr. S. Krabbe, Copenhagen Center for Arthritis Research, Center for Rheumatology and Spine Diseases, Rigshospitalet, Glostrup, Valdemar Hansens Vej 17, DK-2600 Glostrup, Denmark. E-mail: simonkrabbe@gmail.com. Accepted for publication November 17, 2017.
Ole R. Madsen
From the Copenhagen Center for Arthritis Research, Center for Rheumatology and Spine Diseases, and Department of Clinical Biochemistry, Rigshospitalet, Glostrup; Department of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen; Center for Rheumatology and Spine Diseases, Frederiksberg Hospital, Frederiksberg; Department of Radiology, Copenhagen University Hospital Herlev, Herlev; Center for Rheumatology and Spine Diseases, Copenhagen University Hospital Gentofte, Hellerup; Department of Rheumatology, Zealand University Hospital, Køge; Odense Patient Data Explorative Network (OPEN), Odense University Hospital/Institute of Clinical Research, Odense, Denmark; Department of Diagnostic Imaging, Sheba Medical Center (affiliated with the Sackler School of Medicine, Tel Aviv University), Ramat Gan, Israel. The work was supported by AbbVie. AbbVie had no role in the study design or in the collection, analysis, or interpretation of the data, the writing of the manuscript, or the decision to submit the manuscript for publication; publication of this article was not contingent upon approval by AbbVie. SK had a grant from The Danish Rheumatism Association (A3866). S. Krabbe, MD, Copenhagen Center for Arthritis Research, Center for Rheumatology and Spine Diseases, Rigshospitalet, and Department of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen; M. Østergaard, MD, PhD, DMSc, Copenhagen Center for Arthritis Research, Center for Rheumatology and Spine Diseases, Rigshospitalet, and Department of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen; I. Eshed, MD, Department of Diagnostic Imaging, Sheba Medical Center; I.J. Sørensen, MD, PhD, Copenhagen Center for Arthritis Research, Center for Rheumatology and Spine Diseases, Rigshospitalet, and Department of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen; B. Jensen, MD, Center for Rheumatology and Spine Diseases, Frederiksberg Hospital; J.M. Møller, Radiographer, Department of Radiology, Copenhagen University Hospital Herlev; L. Balding, MD, Department of Radiology, Copenhagen University Hospital Herlev; O.R. Madsen, MD, PhD, DMSc, Center for Rheumatology and Spine Diseases, Copenhagen University Hospital Gentofte; K. Asmussen, MD, PhD, Center for Rheumatology and Spine Diseases, Frederiksberg Hospital; G. Eng, MD, PhD, Department of Rheumatology, Zealand University Hospital Køge; N.R. Jørgensen, MD, PhD, DMSc, Department of Clinical Biochemistry, Rigshospitalet, and OPEN, Odense University Hospital/Institute of Clinical Research; S.J. Pedersen, MD, PhD, Copenhagen Center for Arthritis Research, Center for Rheumatology and Spine Diseases, Rigshospitalet, and Center for Rheumatology and Spine Diseases, Copenhagen University Hospital Gentofte. Address correspondence to Dr. S. Krabbe, Copenhagen Center for Arthritis Research, Center for Rheumatology and Spine Diseases, Rigshospitalet, Glostrup, Valdemar Hansens Vej 17, DK-2600 Glostrup, Denmark. E-mail: simonkrabbe@gmail.com. Accepted for publication November 17, 2017.
Karsten Asmussen
From the Copenhagen Center for Arthritis Research, Center for Rheumatology and Spine Diseases, and Department of Clinical Biochemistry, Rigshospitalet, Glostrup; Department of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen; Center for Rheumatology and Spine Diseases, Frederiksberg Hospital, Frederiksberg; Department of Radiology, Copenhagen University Hospital Herlev, Herlev; Center for Rheumatology and Spine Diseases, Copenhagen University Hospital Gentofte, Hellerup; Department of Rheumatology, Zealand University Hospital, Køge; Odense Patient Data Explorative Network (OPEN), Odense University Hospital/Institute of Clinical Research, Odense, Denmark; Department of Diagnostic Imaging, Sheba Medical Center (affiliated with the Sackler School of Medicine, Tel Aviv University), Ramat Gan, Israel. The work was supported by AbbVie. AbbVie had no role in the study design or in the collection, analysis, or interpretation of the data, the writing of the manuscript, or the decision to submit the manuscript for publication; publication of this article was not contingent upon approval by AbbVie. SK had a grant from The Danish Rheumatism Association (A3866). S. Krabbe, MD, Copenhagen Center for Arthritis Research, Center for Rheumatology and Spine Diseases, Rigshospitalet, and Department of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen; M. Østergaard, MD, PhD, DMSc, Copenhagen Center for Arthritis Research, Center for Rheumatology and Spine Diseases, Rigshospitalet, and Department of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen; I. Eshed, MD, Department of Diagnostic Imaging, Sheba Medical Center; I.J. Sørensen, MD, PhD, Copenhagen Center for Arthritis Research, Center for Rheumatology and Spine Diseases, Rigshospitalet, and Department of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen; B. Jensen, MD, Center for Rheumatology and Spine Diseases, Frederiksberg Hospital; J.M. Møller, Radiographer, Department of Radiology, Copenhagen University Hospital Herlev; L. Balding, MD, Department of Radiology, Copenhagen University Hospital Herlev; O.R. Madsen, MD, PhD, DMSc, Center for Rheumatology and Spine Diseases, Copenhagen University Hospital Gentofte; K. Asmussen, MD, PhD, Center for Rheumatology and Spine Diseases, Frederiksberg Hospital; G. Eng, MD, PhD, Department of Rheumatology, Zealand University Hospital Køge; N.R. Jørgensen, MD, PhD, DMSc, Department of Clinical Biochemistry, Rigshospitalet, and OPEN, Odense University Hospital/Institute of Clinical Research; S.J. Pedersen, MD, PhD, Copenhagen Center for Arthritis Research, Center for Rheumatology and Spine Diseases, Rigshospitalet, and Center for Rheumatology and Spine Diseases, Copenhagen University Hospital Gentofte. Address correspondence to Dr. S. Krabbe, Copenhagen Center for Arthritis Research, Center for Rheumatology and Spine Diseases, Rigshospitalet, Glostrup, Valdemar Hansens Vej 17, DK-2600 Glostrup, Denmark. E-mail: simonkrabbe@gmail.com. Accepted for publication November 17, 2017.
Grith Eng
From the Copenhagen Center for Arthritis Research, Center for Rheumatology and Spine Diseases, and Department of Clinical Biochemistry, Rigshospitalet, Glostrup; Department of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen; Center for Rheumatology and Spine Diseases, Frederiksberg Hospital, Frederiksberg; Department of Radiology, Copenhagen University Hospital Herlev, Herlev; Center for Rheumatology and Spine Diseases, Copenhagen University Hospital Gentofte, Hellerup; Department of Rheumatology, Zealand University Hospital, Køge; Odense Patient Data Explorative Network (OPEN), Odense University Hospital/Institute of Clinical Research, Odense, Denmark; Department of Diagnostic Imaging, Sheba Medical Center (affiliated with the Sackler School of Medicine, Tel Aviv University), Ramat Gan, Israel. The work was supported by AbbVie. AbbVie had no role in the study design or in the collection, analysis, or interpretation of the data, the writing of the manuscript, or the decision to submit the manuscript for publication; publication of this article was not contingent upon approval by AbbVie. SK had a grant from The Danish Rheumatism Association (A3866). S. Krabbe, MD, Copenhagen Center for Arthritis Research, Center for Rheumatology and Spine Diseases, Rigshospitalet, and Department of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen; M. Østergaard, MD, PhD, DMSc, Copenhagen Center for Arthritis Research, Center for Rheumatology and Spine Diseases, Rigshospitalet, and Department of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen; I. Eshed, MD, Department of Diagnostic Imaging, Sheba Medical Center; I.J. Sørensen, MD, PhD, Copenhagen Center for Arthritis Research, Center for Rheumatology and Spine Diseases, Rigshospitalet, and Department of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen; B. Jensen, MD, Center for Rheumatology and Spine Diseases, Frederiksberg Hospital; J.M. Møller, Radiographer, Department of Radiology, Copenhagen University Hospital Herlev; L. Balding, MD, Department of Radiology, Copenhagen University Hospital Herlev; O.R. Madsen, MD, PhD, DMSc, Center for Rheumatology and Spine Diseases, Copenhagen University Hospital Gentofte; K. Asmussen, MD, PhD, Center for Rheumatology and Spine Diseases, Frederiksberg Hospital; G. Eng, MD, PhD, Department of Rheumatology, Zealand University Hospital Køge; N.R. Jørgensen, MD, PhD, DMSc, Department of Clinical Biochemistry, Rigshospitalet, and OPEN, Odense University Hospital/Institute of Clinical Research; S.J. Pedersen, MD, PhD, Copenhagen Center for Arthritis Research, Center for Rheumatology and Spine Diseases, Rigshospitalet, and Center for Rheumatology and Spine Diseases, Copenhagen University Hospital Gentofte. Address correspondence to Dr. S. Krabbe, Copenhagen Center for Arthritis Research, Center for Rheumatology and Spine Diseases, Rigshospitalet, Glostrup, Valdemar Hansens Vej 17, DK-2600 Glostrup, Denmark. E-mail: simonkrabbe@gmail.com. Accepted for publication November 17, 2017.
Niklas R. Jørgensen
From the Copenhagen Center for Arthritis Research, Center for Rheumatology and Spine Diseases, and Department of Clinical Biochemistry, Rigshospitalet, Glostrup; Department of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen; Center for Rheumatology and Spine Diseases, Frederiksberg Hospital, Frederiksberg; Department of Radiology, Copenhagen University Hospital Herlev, Herlev; Center for Rheumatology and Spine Diseases, Copenhagen University Hospital Gentofte, Hellerup; Department of Rheumatology, Zealand University Hospital, Køge; Odense Patient Data Explorative Network (OPEN), Odense University Hospital/Institute of Clinical Research, Odense, Denmark; Department of Diagnostic Imaging, Sheba Medical Center (affiliated with the Sackler School of Medicine, Tel Aviv University), Ramat Gan, Israel. The work was supported by AbbVie. AbbVie had no role in the study design or in the collection, analysis, or interpretation of the data, the writing of the manuscript, or the decision to submit the manuscript for publication; publication of this article was not contingent upon approval by AbbVie. SK had a grant from The Danish Rheumatism Association (A3866). S. Krabbe, MD, Copenhagen Center for Arthritis Research, Center for Rheumatology and Spine Diseases, Rigshospitalet, and Department of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen; M. Østergaard, MD, PhD, DMSc, Copenhagen Center for Arthritis Research, Center for Rheumatology and Spine Diseases, Rigshospitalet, and Department of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen; I. Eshed, MD, Department of Diagnostic Imaging, Sheba Medical Center; I.J. Sørensen, MD, PhD, Copenhagen Center for Arthritis Research, Center for Rheumatology and Spine Diseases, Rigshospitalet, and Department of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen; B. Jensen, MD, Center for Rheumatology and Spine Diseases, Frederiksberg Hospital; J.M. Møller, Radiographer, Department of Radiology, Copenhagen University Hospital Herlev; L. Balding, MD, Department of Radiology, Copenhagen University Hospital Herlev; O.R. Madsen, MD, PhD, DMSc, Center for Rheumatology and Spine Diseases, Copenhagen University Hospital Gentofte; K. Asmussen, MD, PhD, Center for Rheumatology and Spine Diseases, Frederiksberg Hospital; G. Eng, MD, PhD, Department of Rheumatology, Zealand University Hospital Køge; N.R. Jørgensen, MD, PhD, DMSc, Department of Clinical Biochemistry, Rigshospitalet, and OPEN, Odense University Hospital/Institute of Clinical Research; S.J. Pedersen, MD, PhD, Copenhagen Center for Arthritis Research, Center for Rheumatology and Spine Diseases, Rigshospitalet, and Center for Rheumatology and Spine Diseases, Copenhagen University Hospital Gentofte. Address correspondence to Dr. S. Krabbe, Copenhagen Center for Arthritis Research, Center for Rheumatology and Spine Diseases, Rigshospitalet, Glostrup, Valdemar Hansens Vej 17, DK-2600 Glostrup, Denmark. E-mail: simonkrabbe@gmail.com. Accepted for publication November 17, 2017.
Susanne J. Pedersen
From the Copenhagen Center for Arthritis Research, Center for Rheumatology and Spine Diseases, and Department of Clinical Biochemistry, Rigshospitalet, Glostrup; Department of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen; Center for Rheumatology and Spine Diseases, Frederiksberg Hospital, Frederiksberg; Department of Radiology, Copenhagen University Hospital Herlev, Herlev; Center for Rheumatology and Spine Diseases, Copenhagen University Hospital Gentofte, Hellerup; Department of Rheumatology, Zealand University Hospital, Køge; Odense Patient Data Explorative Network (OPEN), Odense University Hospital/Institute of Clinical Research, Odense, Denmark; Department of Diagnostic Imaging, Sheba Medical Center (affiliated with the Sackler School of Medicine, Tel Aviv University), Ramat Gan, Israel. The work was supported by AbbVie. AbbVie had no role in the study design or in the collection, analysis, or interpretation of the data, the writing of the manuscript, or the decision to submit the manuscript for publication; publication of this article was not contingent upon approval by AbbVie. SK had a grant from The Danish Rheumatism Association (A3866). S. Krabbe, MD, Copenhagen Center for Arthritis Research, Center for Rheumatology and Spine Diseases, Rigshospitalet, and Department of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen; M. Østergaard, MD, PhD, DMSc, Copenhagen Center for Arthritis Research, Center for Rheumatology and Spine Diseases, Rigshospitalet, and Department of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen; I. Eshed, MD, Department of Diagnostic Imaging, Sheba Medical Center; I.J. Sørensen, MD, PhD, Copenhagen Center for Arthritis Research, Center for Rheumatology and Spine Diseases, Rigshospitalet, and Department of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen; B. Jensen, MD, Center for Rheumatology and Spine Diseases, Frederiksberg Hospital; J.M. Møller, Radiographer, Department of Radiology, Copenhagen University Hospital Herlev; L. Balding, MD, Department of Radiology, Copenhagen University Hospital Herlev; O.R. Madsen, MD, PhD, DMSc, Center for Rheumatology and Spine Diseases, Copenhagen University Hospital Gentofte; K. Asmussen, MD, PhD, Center for Rheumatology and Spine Diseases, Frederiksberg Hospital; G. Eng, MD, PhD, Department of Rheumatology, Zealand University Hospital Køge; N.R. Jørgensen, MD, PhD, DMSc, Department of Clinical Biochemistry, Rigshospitalet, and OPEN, Odense University Hospital/Institute of Clinical Research; S.J. Pedersen, MD, PhD, Copenhagen Center for Arthritis Research, Center for Rheumatology and Spine Diseases, Rigshospitalet, and Center for Rheumatology and Spine Diseases, Copenhagen University Hospital Gentofte. Address correspondence to Dr. S. Krabbe, Copenhagen Center for Arthritis Research, Center for Rheumatology and Spine Diseases, Rigshospitalet, Glostrup, Valdemar Hansens Vej 17, DK-2600 Glostrup, Denmark. E-mail: simonkrabbe@gmail.com. Accepted for publication November 17, 2017.
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- Published online February 15, 2018.
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© 2018 The Journal of Rheumatology
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- Simon Krabbe,
- Mikkel Østergaard,
- Iris Eshed,
- Inge J. Sørensen,
- Bente Jensen,
- Jakob M. Møller,
- Lone Balding,
- Ole R. Madsen,
- Karsten Asmussen,
- Grith Eng,
- Niklas R. Jørgensen and
- Susanne J. Pedersen
- From the Copenhagen Center for Arthritis Research, Center for Rheumatology and Spine Diseases, and Department of Clinical Biochemistry, Rigshospitalet, Glostrup; Department of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen; Center for Rheumatology and Spine Diseases, Frederiksberg Hospital, Frederiksberg; Department of Radiology, Copenhagen University Hospital Herlev, Herlev; Center for Rheumatology and Spine Diseases, Copenhagen University Hospital Gentofte, Hellerup; Department of Rheumatology, Zealand University Hospital, Køge; Odense Patient Data Explorative Network (OPEN), Odense University Hospital/Institute of Clinical Research, Odense, Denmark; Department of Diagnostic Imaging, Sheba Medical Center (affiliated with the Sackler School of Medicine, Tel Aviv University), Ramat Gan, Israel.
The work was supported by AbbVie. AbbVie had no role in the study design or in the collection, analysis, or interpretation of the data, the writing of the manuscript, or the decision to submit the manuscript for publication; publication of this article was not contingent upon approval by AbbVie.
SK had a grant from The Danish Rheumatism Association (A3866).
S. Krabbe, MD, Copenhagen Center for Arthritis Research, Center for Rheumatology and Spine Diseases, Rigshospitalet, and Department of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen; M. Østergaard, MD, PhD, DMSc, Copenhagen Center for Arthritis Research, Center for Rheumatology and Spine Diseases, Rigshospitalet, and Department of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen; I. Eshed, MD, Department of Diagnostic Imaging, Sheba Medical Center; I.J. Sørensen, MD, PhD, Copenhagen Center for Arthritis Research, Center for Rheumatology and Spine Diseases, Rigshospitalet, and Department of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen; B. Jensen, MD, Center for Rheumatology and Spine Diseases, Frederiksberg Hospital; J.M. Møller, Radiographer, Department of Radiology, Copenhagen University Hospital Herlev; L. Balding, MD, Department of Radiology, Copenhagen University Hospital Herlev; O.R. Madsen, MD, PhD, DMSc, Center for Rheumatology and Spine Diseases, Copenhagen University Hospital Gentofte; K. Asmussen, MD, PhD, Center for Rheumatology and Spine Diseases, Frederiksberg Hospital; G. Eng, MD, PhD, Department of Rheumatology, Zealand University Hospital Køge; N.R. Jørgensen, MD, PhD, DMSc, Department of Clinical Biochemistry, Rigshospitalet, and OPEN, Odense University Hospital/Institute of Clinical Research; S.J. Pedersen, MD, PhD, Copenhagen Center for Arthritis Research, Center for Rheumatology and Spine Diseases, Rigshospitalet, and Center for Rheumatology and Spine Diseases, Copenhagen University Hospital Gentofte.
Address correspondence to Dr. S. Krabbe, Copenhagen Center for Arthritis Research, Center for Rheumatology and Spine Diseases, Rigshospitalet, Glostrup, Valdemar Hansens Vej 17, DK-2600 Glostrup, Denmark. E-mail: simonkrabbe@gmail.com.
Accepted for publication November 17, 2017.
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In this issue
The Journal of Rheumatology
Vol. 51, Issue 4
1 Apr 2024
Whole-body Magnetic Resonance Imaging in Axial Spondyloarthritis: Reduction of Sacroiliac, Spinal, and Entheseal Inflammation in a Placebo-controlled Trial of Adalimumab
Simon Krabbe, Mikkel Østergaard, Iris Eshed, Inge J. Sørensen, Bente Jensen, Jakob M. Møller, Lone Balding, Ole R. Madsen, Karsten Asmussen, Grith Eng, Niklas R. Jørgensen, Susanne J. Pedersen
The Journal of Rheumatology Feb 2018, jrheum.170408; DOI: 10.3899/jrheum.170408
Whole-body Magnetic Resonance Imaging in Axial Spondyloarthritis: Reduction of Sacroiliac, Spinal, and Entheseal Inflammation in a Placebo-controlled Trial of Adalimumab
Simon Krabbe, Mikkel Østergaard, Iris Eshed, Inge J. Sørensen, Bente Jensen, Jakob M. Møller, Lone Balding, Ole R. Madsen, Karsten Asmussen, Grith Eng, Niklas R. Jørgensen, Susanne J. Pedersen
The Journal of Rheumatology Feb 2018, jrheum.170408; DOI: 10.3899/jrheum.170408