Research ArticleArticle
Risk Factors for Relapse of Antineutrophil Cytoplasmic Antibody-associated Vasculitis in Japan: A Nationwide, Prospective Cohort Study
Akinori Hara, Takashi Wada, Ken-ei Sada, Koichi Amano, Hiroaki Dobashi, Masayoshi Harigai, Yoshinari Takasaki, Hidehiro Yamada, Hitoshi Hasegawa, Taichi Hayashi, Shouichi Fujimoto, Eri Muso, Tamihiro Kawakami, Sakae Homma, Masaharu Yoshida, Junichi Hirahashi, Noriyoshi Ogawa, Satoshi Ito, Hirofumi Makino and Yoshihiro Arimura for the Research Committee on Intractable Vasculitides and the Strategic Study Group to Establish the Evidence for Intractable Vasculitis Guideline
The Journal of Rheumatology February 2018, jrheum.170508; DOI: https://doi.org/10.3899/jrheum.170508
Akinori Hara
From the Department of Environmental and Preventive Medicine, and Department of Nephrology and Laboratory Medicine, Faculty of Medicine, Institute of Medical, Pharmaceutical and Health Sciences, Kanazawa University, Kanazawa; Department of Nephrology, Rheumatology, Endocrinology and Metabolism, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama; Department of Rheumatology and Clinical Immunology, Saitama Medical Center, Saitama; Division of Endocrinology and Metabolism, Hematology, Rheumatology and Respiratory Medicine, Department of Internal Medicine, Faculty of Medicine, Kagawa University, Kagawa; Division of Rheumatology and Allergology, Departments of Internal Medicine and Dermatology, St. Marianna University School of Medicine, Kawasaki; Department of Hematology, Clinical Immunology and Infectious Diseases, Ehime University Graduate School of Medicine, Matsuyama; Department of Rheumatology, Faculty of Medicine, University of Tsukuba, Tsukuba; Department of Hemovascular Medicine and Artificial Organs, Faculty of Medicine, University of Miyazaki, Miyazaki; Center for Nephrology and Urology, Division of Nephrology and Dialysis, Kitano Hospital, Tazuke Kofukai Medical Research Institute, Osaka; Third Department of Internal Medicine, Division of Immunology and Rheumatology, Hamamatsu University School of Medicine, Hamamatsu; Division of Rheumatology, Niigata Rheumatic Center, Shibata; Department of Pharmacovigilance, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University; Department of Internal Medicine and Rheumatology, Juntendo University School of Medicine; Department of Respiratory Medicine, Toho University Omori Medical Center; Division of Nephrology, Tokyo Medical University Hachioji Medical Center; Department of Nephrology and Endocrinology, Graduate School of Medicine, The University of Tokyo; Nephrology and Rheumatology, First Department of Internal Medicine, Kyorin University School of Medicine, Tokyo, Japan. Supported by grants for Research on Rare and Intractable Diseases, the Ministry of Health, Labor and Welfare, Japan (nannti-ippann-044), and the Study Group for Strategic Exploration of Drug Seeds for ANCA-associated Vasculitis and Construction of Clinical Evidence from the Japan Agency for Medical Research and Development (16ek0109121h0002). A. Hara, MD, PhD, Department of Environmental and Preventive Medicine, Kanazawa University; T. Wada, MD, PhD, Department of Nephrology and Laboratory Medicine, Faculty of Medicine, Institute of Medical, Pharmaceutical and Health Sciences, Kanazawa University; K. Sada, MD, PhD, Department of Nephrology, Rheumatology, Endocrinology and Metabolism, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences; K. Amano, MD, PhD, Department of Rheumatology and Clinical Immunology, Saitama Medical Center; H. Dobashi, MD, PhD, Division of Endocrinology and Metabolism, Hematology, Rheumatology and Respiratory Medicine, Department of Internal Medicine, Faculty of Medicine, Kagawa University; M. Harigai, MD, PhD, Department of Pharmacovigilance, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University; Y. Takasaki, MD, PhD, Department of Internal Medicine and Rheumatology, Juntendo University School of Medicine; H. Yamada, MD, PhD, Division of Rheumatology and Allergology, Department of Internal Medicine, St. Marianna University School of Medicine; H. Hasegawa, MD, PhD, Department of Hematology, Clinical Immunology and Infectious Diseases, Ehime University Graduate School of Medicine; T. Hayashi, MD, PhD, Department of Rheumatology, Faculty of Medicine, University of Tsukuba; S. Fujimoto, MD, PhD, Department of Hemovascular Medicine and Artificial Organs, Faculty of Medicine, University of Miyazaki; E. Muso, MD, PhD, Center for Nephrology and Urology, Division of Nephrology and Dialysis, Kitano Hospital, Tazuke Kofukai Medical Research Institute; T. Kawakami, MD, PhD, Department of Dermatology, St. Marianna University School of Medicine; S. Homma, MD, PhD, Department of Respiratory Medicine, Toho University Omori Medical Center; M. Yoshida, MD, PhD, Division of Nephrology, Tokyo Medical University, Hachioji Medical Center; J. Hirahashi, MD, PhD, Department of Nephrology and Endocrinology, Graduate School of Medicine, The University of Tokyo; N. Ogawa, MD, PhD, Third Department of Internal Medicine, Division of Immunology and Rheumatology, Hamamatsu University School of Medicine; S. Ito, MD, PhD, Division of Rheumatology, Niigata Rheumatic Center; H. Makino, MD, PhD, Department of Nephrology, Rheumatology, Endocrinology and Metabolism, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences; Y. Arimura, MD, PhD, Nephrology and Rheumatology, First Department of Internal Medicine, Kyorin University School of Medicine. Address correspondence to Dr. T. Wada, Department of Nephrology and Laboratory Medicine, Institute of Medical, Pharmaceutical and Health Sciences, Faculty of Medicine, Kanazawa University, 13-1 Takara-machi, Kanazawa 920-8641, Japan. E-mail: twada@m-kanazawa.jp. Accepted for publication November 6, 2017.
Takashi Wada
From the Department of Environmental and Preventive Medicine, and Department of Nephrology and Laboratory Medicine, Faculty of Medicine, Institute of Medical, Pharmaceutical and Health Sciences, Kanazawa University, Kanazawa; Department of Nephrology, Rheumatology, Endocrinology and Metabolism, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama; Department of Rheumatology and Clinical Immunology, Saitama Medical Center, Saitama; Division of Endocrinology and Metabolism, Hematology, Rheumatology and Respiratory Medicine, Department of Internal Medicine, Faculty of Medicine, Kagawa University, Kagawa; Division of Rheumatology and Allergology, Departments of Internal Medicine and Dermatology, St. Marianna University School of Medicine, Kawasaki; Department of Hematology, Clinical Immunology and Infectious Diseases, Ehime University Graduate School of Medicine, Matsuyama; Department of Rheumatology, Faculty of Medicine, University of Tsukuba, Tsukuba; Department of Hemovascular Medicine and Artificial Organs, Faculty of Medicine, University of Miyazaki, Miyazaki; Center for Nephrology and Urology, Division of Nephrology and Dialysis, Kitano Hospital, Tazuke Kofukai Medical Research Institute, Osaka; Third Department of Internal Medicine, Division of Immunology and Rheumatology, Hamamatsu University School of Medicine, Hamamatsu; Division of Rheumatology, Niigata Rheumatic Center, Shibata; Department of Pharmacovigilance, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University; Department of Internal Medicine and Rheumatology, Juntendo University School of Medicine; Department of Respiratory Medicine, Toho University Omori Medical Center; Division of Nephrology, Tokyo Medical University Hachioji Medical Center; Department of Nephrology and Endocrinology, Graduate School of Medicine, The University of Tokyo; Nephrology and Rheumatology, First Department of Internal Medicine, Kyorin University School of Medicine, Tokyo, Japan. Supported by grants for Research on Rare and Intractable Diseases, the Ministry of Health, Labor and Welfare, Japan (nannti-ippann-044), and the Study Group for Strategic Exploration of Drug Seeds for ANCA-associated Vasculitis and Construction of Clinical Evidence from the Japan Agency for Medical Research and Development (16ek0109121h0002). A. Hara, MD, PhD, Department of Environmental and Preventive Medicine, Kanazawa University; T. Wada, MD, PhD, Department of Nephrology and Laboratory Medicine, Faculty of Medicine, Institute of Medical, Pharmaceutical and Health Sciences, Kanazawa University; K. Sada, MD, PhD, Department of Nephrology, Rheumatology, Endocrinology and Metabolism, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences; K. Amano, MD, PhD, Department of Rheumatology and Clinical Immunology, Saitama Medical Center; H. Dobashi, MD, PhD, Division of Endocrinology and Metabolism, Hematology, Rheumatology and Respiratory Medicine, Department of Internal Medicine, Faculty of Medicine, Kagawa University; M. Harigai, MD, PhD, Department of Pharmacovigilance, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University; Y. Takasaki, MD, PhD, Department of Internal Medicine and Rheumatology, Juntendo University School of Medicine; H. Yamada, MD, PhD, Division of Rheumatology and Allergology, Department of Internal Medicine, St. Marianna University School of Medicine; H. Hasegawa, MD, PhD, Department of Hematology, Clinical Immunology and Infectious Diseases, Ehime University Graduate School of Medicine; T. Hayashi, MD, PhD, Department of Rheumatology, Faculty of Medicine, University of Tsukuba; S. Fujimoto, MD, PhD, Department of Hemovascular Medicine and Artificial Organs, Faculty of Medicine, University of Miyazaki; E. Muso, MD, PhD, Center for Nephrology and Urology, Division of Nephrology and Dialysis, Kitano Hospital, Tazuke Kofukai Medical Research Institute; T. Kawakami, MD, PhD, Department of Dermatology, St. Marianna University School of Medicine; S. Homma, MD, PhD, Department of Respiratory Medicine, Toho University Omori Medical Center; M. Yoshida, MD, PhD, Division of Nephrology, Tokyo Medical University, Hachioji Medical Center; J. Hirahashi, MD, PhD, Department of Nephrology and Endocrinology, Graduate School of Medicine, The University of Tokyo; N. Ogawa, MD, PhD, Third Department of Internal Medicine, Division of Immunology and Rheumatology, Hamamatsu University School of Medicine; S. Ito, MD, PhD, Division of Rheumatology, Niigata Rheumatic Center; H. Makino, MD, PhD, Department of Nephrology, Rheumatology, Endocrinology and Metabolism, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences; Y. Arimura, MD, PhD, Nephrology and Rheumatology, First Department of Internal Medicine, Kyorin University School of Medicine. Address correspondence to Dr. T. Wada, Department of Nephrology and Laboratory Medicine, Institute of Medical, Pharmaceutical and Health Sciences, Faculty of Medicine, Kanazawa University, 13-1 Takara-machi, Kanazawa 920-8641, Japan. E-mail: twada@m-kanazawa.jp. Accepted for publication November 6, 2017.
Ken-ei Sada
From the Department of Environmental and Preventive Medicine, and Department of Nephrology and Laboratory Medicine, Faculty of Medicine, Institute of Medical, Pharmaceutical and Health Sciences, Kanazawa University, Kanazawa; Department of Nephrology, Rheumatology, Endocrinology and Metabolism, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama; Department of Rheumatology and Clinical Immunology, Saitama Medical Center, Saitama; Division of Endocrinology and Metabolism, Hematology, Rheumatology and Respiratory Medicine, Department of Internal Medicine, Faculty of Medicine, Kagawa University, Kagawa; Division of Rheumatology and Allergology, Departments of Internal Medicine and Dermatology, St. Marianna University School of Medicine, Kawasaki; Department of Hematology, Clinical Immunology and Infectious Diseases, Ehime University Graduate School of Medicine, Matsuyama; Department of Rheumatology, Faculty of Medicine, University of Tsukuba, Tsukuba; Department of Hemovascular Medicine and Artificial Organs, Faculty of Medicine, University of Miyazaki, Miyazaki; Center for Nephrology and Urology, Division of Nephrology and Dialysis, Kitano Hospital, Tazuke Kofukai Medical Research Institute, Osaka; Third Department of Internal Medicine, Division of Immunology and Rheumatology, Hamamatsu University School of Medicine, Hamamatsu; Division of Rheumatology, Niigata Rheumatic Center, Shibata; Department of Pharmacovigilance, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University; Department of Internal Medicine and Rheumatology, Juntendo University School of Medicine; Department of Respiratory Medicine, Toho University Omori Medical Center; Division of Nephrology, Tokyo Medical University Hachioji Medical Center; Department of Nephrology and Endocrinology, Graduate School of Medicine, The University of Tokyo; Nephrology and Rheumatology, First Department of Internal Medicine, Kyorin University School of Medicine, Tokyo, Japan. Supported by grants for Research on Rare and Intractable Diseases, the Ministry of Health, Labor and Welfare, Japan (nannti-ippann-044), and the Study Group for Strategic Exploration of Drug Seeds for ANCA-associated Vasculitis and Construction of Clinical Evidence from the Japan Agency for Medical Research and Development (16ek0109121h0002). A. Hara, MD, PhD, Department of Environmental and Preventive Medicine, Kanazawa University; T. Wada, MD, PhD, Department of Nephrology and Laboratory Medicine, Faculty of Medicine, Institute of Medical, Pharmaceutical and Health Sciences, Kanazawa University; K. Sada, MD, PhD, Department of Nephrology, Rheumatology, Endocrinology and Metabolism, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences; K. Amano, MD, PhD, Department of Rheumatology and Clinical Immunology, Saitama Medical Center; H. Dobashi, MD, PhD, Division of Endocrinology and Metabolism, Hematology, Rheumatology and Respiratory Medicine, Department of Internal Medicine, Faculty of Medicine, Kagawa University; M. Harigai, MD, PhD, Department of Pharmacovigilance, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University; Y. Takasaki, MD, PhD, Department of Internal Medicine and Rheumatology, Juntendo University School of Medicine; H. Yamada, MD, PhD, Division of Rheumatology and Allergology, Department of Internal Medicine, St. Marianna University School of Medicine; H. Hasegawa, MD, PhD, Department of Hematology, Clinical Immunology and Infectious Diseases, Ehime University Graduate School of Medicine; T. Hayashi, MD, PhD, Department of Rheumatology, Faculty of Medicine, University of Tsukuba; S. Fujimoto, MD, PhD, Department of Hemovascular Medicine and Artificial Organs, Faculty of Medicine, University of Miyazaki; E. Muso, MD, PhD, Center for Nephrology and Urology, Division of Nephrology and Dialysis, Kitano Hospital, Tazuke Kofukai Medical Research Institute; T. Kawakami, MD, PhD, Department of Dermatology, St. Marianna University School of Medicine; S. Homma, MD, PhD, Department of Respiratory Medicine, Toho University Omori Medical Center; M. Yoshida, MD, PhD, Division of Nephrology, Tokyo Medical University, Hachioji Medical Center; J. Hirahashi, MD, PhD, Department of Nephrology and Endocrinology, Graduate School of Medicine, The University of Tokyo; N. Ogawa, MD, PhD, Third Department of Internal Medicine, Division of Immunology and Rheumatology, Hamamatsu University School of Medicine; S. Ito, MD, PhD, Division of Rheumatology, Niigata Rheumatic Center; H. Makino, MD, PhD, Department of Nephrology, Rheumatology, Endocrinology and Metabolism, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences; Y. Arimura, MD, PhD, Nephrology and Rheumatology, First Department of Internal Medicine, Kyorin University School of Medicine. Address correspondence to Dr. T. Wada, Department of Nephrology and Laboratory Medicine, Institute of Medical, Pharmaceutical and Health Sciences, Faculty of Medicine, Kanazawa University, 13-1 Takara-machi, Kanazawa 920-8641, Japan. E-mail: twada@m-kanazawa.jp. Accepted for publication November 6, 2017.
Koichi Amano
From the Department of Environmental and Preventive Medicine, and Department of Nephrology and Laboratory Medicine, Faculty of Medicine, Institute of Medical, Pharmaceutical and Health Sciences, Kanazawa University, Kanazawa; Department of Nephrology, Rheumatology, Endocrinology and Metabolism, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama; Department of Rheumatology and Clinical Immunology, Saitama Medical Center, Saitama; Division of Endocrinology and Metabolism, Hematology, Rheumatology and Respiratory Medicine, Department of Internal Medicine, Faculty of Medicine, Kagawa University, Kagawa; Division of Rheumatology and Allergology, Departments of Internal Medicine and Dermatology, St. Marianna University School of Medicine, Kawasaki; Department of Hematology, Clinical Immunology and Infectious Diseases, Ehime University Graduate School of Medicine, Matsuyama; Department of Rheumatology, Faculty of Medicine, University of Tsukuba, Tsukuba; Department of Hemovascular Medicine and Artificial Organs, Faculty of Medicine, University of Miyazaki, Miyazaki; Center for Nephrology and Urology, Division of Nephrology and Dialysis, Kitano Hospital, Tazuke Kofukai Medical Research Institute, Osaka; Third Department of Internal Medicine, Division of Immunology and Rheumatology, Hamamatsu University School of Medicine, Hamamatsu; Division of Rheumatology, Niigata Rheumatic Center, Shibata; Department of Pharmacovigilance, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University; Department of Internal Medicine and Rheumatology, Juntendo University School of Medicine; Department of Respiratory Medicine, Toho University Omori Medical Center; Division of Nephrology, Tokyo Medical University Hachioji Medical Center; Department of Nephrology and Endocrinology, Graduate School of Medicine, The University of Tokyo; Nephrology and Rheumatology, First Department of Internal Medicine, Kyorin University School of Medicine, Tokyo, Japan. Supported by grants for Research on Rare and Intractable Diseases, the Ministry of Health, Labor and Welfare, Japan (nannti-ippann-044), and the Study Group for Strategic Exploration of Drug Seeds for ANCA-associated Vasculitis and Construction of Clinical Evidence from the Japan Agency for Medical Research and Development (16ek0109121h0002). A. Hara, MD, PhD, Department of Environmental and Preventive Medicine, Kanazawa University; T. Wada, MD, PhD, Department of Nephrology and Laboratory Medicine, Faculty of Medicine, Institute of Medical, Pharmaceutical and Health Sciences, Kanazawa University; K. Sada, MD, PhD, Department of Nephrology, Rheumatology, Endocrinology and Metabolism, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences; K. Amano, MD, PhD, Department of Rheumatology and Clinical Immunology, Saitama Medical Center; H. Dobashi, MD, PhD, Division of Endocrinology and Metabolism, Hematology, Rheumatology and Respiratory Medicine, Department of Internal Medicine, Faculty of Medicine, Kagawa University; M. Harigai, MD, PhD, Department of Pharmacovigilance, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University; Y. Takasaki, MD, PhD, Department of Internal Medicine and Rheumatology, Juntendo University School of Medicine; H. Yamada, MD, PhD, Division of Rheumatology and Allergology, Department of Internal Medicine, St. Marianna University School of Medicine; H. Hasegawa, MD, PhD, Department of Hematology, Clinical Immunology and Infectious Diseases, Ehime University Graduate School of Medicine; T. Hayashi, MD, PhD, Department of Rheumatology, Faculty of Medicine, University of Tsukuba; S. Fujimoto, MD, PhD, Department of Hemovascular Medicine and Artificial Organs, Faculty of Medicine, University of Miyazaki; E. Muso, MD, PhD, Center for Nephrology and Urology, Division of Nephrology and Dialysis, Kitano Hospital, Tazuke Kofukai Medical Research Institute; T. Kawakami, MD, PhD, Department of Dermatology, St. Marianna University School of Medicine; S. Homma, MD, PhD, Department of Respiratory Medicine, Toho University Omori Medical Center; M. Yoshida, MD, PhD, Division of Nephrology, Tokyo Medical University, Hachioji Medical Center; J. Hirahashi, MD, PhD, Department of Nephrology and Endocrinology, Graduate School of Medicine, The University of Tokyo; N. Ogawa, MD, PhD, Third Department of Internal Medicine, Division of Immunology and Rheumatology, Hamamatsu University School of Medicine; S. Ito, MD, PhD, Division of Rheumatology, Niigata Rheumatic Center; H. Makino, MD, PhD, Department of Nephrology, Rheumatology, Endocrinology and Metabolism, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences; Y. Arimura, MD, PhD, Nephrology and Rheumatology, First Department of Internal Medicine, Kyorin University School of Medicine. Address correspondence to Dr. T. Wada, Department of Nephrology and Laboratory Medicine, Institute of Medical, Pharmaceutical and Health Sciences, Faculty of Medicine, Kanazawa University, 13-1 Takara-machi, Kanazawa 920-8641, Japan. E-mail: twada@m-kanazawa.jp. Accepted for publication November 6, 2017.
Hiroaki Dobashi
From the Department of Environmental and Preventive Medicine, and Department of Nephrology and Laboratory Medicine, Faculty of Medicine, Institute of Medical, Pharmaceutical and Health Sciences, Kanazawa University, Kanazawa; Department of Nephrology, Rheumatology, Endocrinology and Metabolism, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama; Department of Rheumatology and Clinical Immunology, Saitama Medical Center, Saitama; Division of Endocrinology and Metabolism, Hematology, Rheumatology and Respiratory Medicine, Department of Internal Medicine, Faculty of Medicine, Kagawa University, Kagawa; Division of Rheumatology and Allergology, Departments of Internal Medicine and Dermatology, St. Marianna University School of Medicine, Kawasaki; Department of Hematology, Clinical Immunology and Infectious Diseases, Ehime University Graduate School of Medicine, Matsuyama; Department of Rheumatology, Faculty of Medicine, University of Tsukuba, Tsukuba; Department of Hemovascular Medicine and Artificial Organs, Faculty of Medicine, University of Miyazaki, Miyazaki; Center for Nephrology and Urology, Division of Nephrology and Dialysis, Kitano Hospital, Tazuke Kofukai Medical Research Institute, Osaka; Third Department of Internal Medicine, Division of Immunology and Rheumatology, Hamamatsu University School of Medicine, Hamamatsu; Division of Rheumatology, Niigata Rheumatic Center, Shibata; Department of Pharmacovigilance, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University; Department of Internal Medicine and Rheumatology, Juntendo University School of Medicine; Department of Respiratory Medicine, Toho University Omori Medical Center; Division of Nephrology, Tokyo Medical University Hachioji Medical Center; Department of Nephrology and Endocrinology, Graduate School of Medicine, The University of Tokyo; Nephrology and Rheumatology, First Department of Internal Medicine, Kyorin University School of Medicine, Tokyo, Japan. Supported by grants for Research on Rare and Intractable Diseases, the Ministry of Health, Labor and Welfare, Japan (nannti-ippann-044), and the Study Group for Strategic Exploration of Drug Seeds for ANCA-associated Vasculitis and Construction of Clinical Evidence from the Japan Agency for Medical Research and Development (16ek0109121h0002). A. Hara, MD, PhD, Department of Environmental and Preventive Medicine, Kanazawa University; T. Wada, MD, PhD, Department of Nephrology and Laboratory Medicine, Faculty of Medicine, Institute of Medical, Pharmaceutical and Health Sciences, Kanazawa University; K. Sada, MD, PhD, Department of Nephrology, Rheumatology, Endocrinology and Metabolism, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences; K. Amano, MD, PhD, Department of Rheumatology and Clinical Immunology, Saitama Medical Center; H. Dobashi, MD, PhD, Division of Endocrinology and Metabolism, Hematology, Rheumatology and Respiratory Medicine, Department of Internal Medicine, Faculty of Medicine, Kagawa University; M. Harigai, MD, PhD, Department of Pharmacovigilance, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University; Y. Takasaki, MD, PhD, Department of Internal Medicine and Rheumatology, Juntendo University School of Medicine; H. Yamada, MD, PhD, Division of Rheumatology and Allergology, Department of Internal Medicine, St. Marianna University School of Medicine; H. Hasegawa, MD, PhD, Department of Hematology, Clinical Immunology and Infectious Diseases, Ehime University Graduate School of Medicine; T. Hayashi, MD, PhD, Department of Rheumatology, Faculty of Medicine, University of Tsukuba; S. Fujimoto, MD, PhD, Department of Hemovascular Medicine and Artificial Organs, Faculty of Medicine, University of Miyazaki; E. Muso, MD, PhD, Center for Nephrology and Urology, Division of Nephrology and Dialysis, Kitano Hospital, Tazuke Kofukai Medical Research Institute; T. Kawakami, MD, PhD, Department of Dermatology, St. Marianna University School of Medicine; S. Homma, MD, PhD, Department of Respiratory Medicine, Toho University Omori Medical Center; M. Yoshida, MD, PhD, Division of Nephrology, Tokyo Medical University, Hachioji Medical Center; J. Hirahashi, MD, PhD, Department of Nephrology and Endocrinology, Graduate School of Medicine, The University of Tokyo; N. Ogawa, MD, PhD, Third Department of Internal Medicine, Division of Immunology and Rheumatology, Hamamatsu University School of Medicine; S. Ito, MD, PhD, Division of Rheumatology, Niigata Rheumatic Center; H. Makino, MD, PhD, Department of Nephrology, Rheumatology, Endocrinology and Metabolism, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences; Y. Arimura, MD, PhD, Nephrology and Rheumatology, First Department of Internal Medicine, Kyorin University School of Medicine. Address correspondence to Dr. T. Wada, Department of Nephrology and Laboratory Medicine, Institute of Medical, Pharmaceutical and Health Sciences, Faculty of Medicine, Kanazawa University, 13-1 Takara-machi, Kanazawa 920-8641, Japan. E-mail: twada@m-kanazawa.jp. Accepted for publication November 6, 2017.
Masayoshi Harigai
From the Department of Environmental and Preventive Medicine, and Department of Nephrology and Laboratory Medicine, Faculty of Medicine, Institute of Medical, Pharmaceutical and Health Sciences, Kanazawa University, Kanazawa; Department of Nephrology, Rheumatology, Endocrinology and Metabolism, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama; Department of Rheumatology and Clinical Immunology, Saitama Medical Center, Saitama; Division of Endocrinology and Metabolism, Hematology, Rheumatology and Respiratory Medicine, Department of Internal Medicine, Faculty of Medicine, Kagawa University, Kagawa; Division of Rheumatology and Allergology, Departments of Internal Medicine and Dermatology, St. Marianna University School of Medicine, Kawasaki; Department of Hematology, Clinical Immunology and Infectious Diseases, Ehime University Graduate School of Medicine, Matsuyama; Department of Rheumatology, Faculty of Medicine, University of Tsukuba, Tsukuba; Department of Hemovascular Medicine and Artificial Organs, Faculty of Medicine, University of Miyazaki, Miyazaki; Center for Nephrology and Urology, Division of Nephrology and Dialysis, Kitano Hospital, Tazuke Kofukai Medical Research Institute, Osaka; Third Department of Internal Medicine, Division of Immunology and Rheumatology, Hamamatsu University School of Medicine, Hamamatsu; Division of Rheumatology, Niigata Rheumatic Center, Shibata; Department of Pharmacovigilance, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University; Department of Internal Medicine and Rheumatology, Juntendo University School of Medicine; Department of Respiratory Medicine, Toho University Omori Medical Center; Division of Nephrology, Tokyo Medical University Hachioji Medical Center; Department of Nephrology and Endocrinology, Graduate School of Medicine, The University of Tokyo; Nephrology and Rheumatology, First Department of Internal Medicine, Kyorin University School of Medicine, Tokyo, Japan. Supported by grants for Research on Rare and Intractable Diseases, the Ministry of Health, Labor and Welfare, Japan (nannti-ippann-044), and the Study Group for Strategic Exploration of Drug Seeds for ANCA-associated Vasculitis and Construction of Clinical Evidence from the Japan Agency for Medical Research and Development (16ek0109121h0002). A. Hara, MD, PhD, Department of Environmental and Preventive Medicine, Kanazawa University; T. Wada, MD, PhD, Department of Nephrology and Laboratory Medicine, Faculty of Medicine, Institute of Medical, Pharmaceutical and Health Sciences, Kanazawa University; K. Sada, MD, PhD, Department of Nephrology, Rheumatology, Endocrinology and Metabolism, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences; K. Amano, MD, PhD, Department of Rheumatology and Clinical Immunology, Saitama Medical Center; H. Dobashi, MD, PhD, Division of Endocrinology and Metabolism, Hematology, Rheumatology and Respiratory Medicine, Department of Internal Medicine, Faculty of Medicine, Kagawa University; M. Harigai, MD, PhD, Department of Pharmacovigilance, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University; Y. Takasaki, MD, PhD, Department of Internal Medicine and Rheumatology, Juntendo University School of Medicine; H. Yamada, MD, PhD, Division of Rheumatology and Allergology, Department of Internal Medicine, St. Marianna University School of Medicine; H. Hasegawa, MD, PhD, Department of Hematology, Clinical Immunology and Infectious Diseases, Ehime University Graduate School of Medicine; T. Hayashi, MD, PhD, Department of Rheumatology, Faculty of Medicine, University of Tsukuba; S. Fujimoto, MD, PhD, Department of Hemovascular Medicine and Artificial Organs, Faculty of Medicine, University of Miyazaki; E. Muso, MD, PhD, Center for Nephrology and Urology, Division of Nephrology and Dialysis, Kitano Hospital, Tazuke Kofukai Medical Research Institute; T. Kawakami, MD, PhD, Department of Dermatology, St. Marianna University School of Medicine; S. Homma, MD, PhD, Department of Respiratory Medicine, Toho University Omori Medical Center; M. Yoshida, MD, PhD, Division of Nephrology, Tokyo Medical University, Hachioji Medical Center; J. Hirahashi, MD, PhD, Department of Nephrology and Endocrinology, Graduate School of Medicine, The University of Tokyo; N. Ogawa, MD, PhD, Third Department of Internal Medicine, Division of Immunology and Rheumatology, Hamamatsu University School of Medicine; S. Ito, MD, PhD, Division of Rheumatology, Niigata Rheumatic Center; H. Makino, MD, PhD, Department of Nephrology, Rheumatology, Endocrinology and Metabolism, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences; Y. Arimura, MD, PhD, Nephrology and Rheumatology, First Department of Internal Medicine, Kyorin University School of Medicine. Address correspondence to Dr. T. Wada, Department of Nephrology and Laboratory Medicine, Institute of Medical, Pharmaceutical and Health Sciences, Faculty of Medicine, Kanazawa University, 13-1 Takara-machi, Kanazawa 920-8641, Japan. E-mail: twada@m-kanazawa.jp. Accepted for publication November 6, 2017.
Yoshinari Takasaki
From the Department of Environmental and Preventive Medicine, and Department of Nephrology and Laboratory Medicine, Faculty of Medicine, Institute of Medical, Pharmaceutical and Health Sciences, Kanazawa University, Kanazawa; Department of Nephrology, Rheumatology, Endocrinology and Metabolism, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama; Department of Rheumatology and Clinical Immunology, Saitama Medical Center, Saitama; Division of Endocrinology and Metabolism, Hematology, Rheumatology and Respiratory Medicine, Department of Internal Medicine, Faculty of Medicine, Kagawa University, Kagawa; Division of Rheumatology and Allergology, Departments of Internal Medicine and Dermatology, St. Marianna University School of Medicine, Kawasaki; Department of Hematology, Clinical Immunology and Infectious Diseases, Ehime University Graduate School of Medicine, Matsuyama; Department of Rheumatology, Faculty of Medicine, University of Tsukuba, Tsukuba; Department of Hemovascular Medicine and Artificial Organs, Faculty of Medicine, University of Miyazaki, Miyazaki; Center for Nephrology and Urology, Division of Nephrology and Dialysis, Kitano Hospital, Tazuke Kofukai Medical Research Institute, Osaka; Third Department of Internal Medicine, Division of Immunology and Rheumatology, Hamamatsu University School of Medicine, Hamamatsu; Division of Rheumatology, Niigata Rheumatic Center, Shibata; Department of Pharmacovigilance, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University; Department of Internal Medicine and Rheumatology, Juntendo University School of Medicine; Department of Respiratory Medicine, Toho University Omori Medical Center; Division of Nephrology, Tokyo Medical University Hachioji Medical Center; Department of Nephrology and Endocrinology, Graduate School of Medicine, The University of Tokyo; Nephrology and Rheumatology, First Department of Internal Medicine, Kyorin University School of Medicine, Tokyo, Japan. Supported by grants for Research on Rare and Intractable Diseases, the Ministry of Health, Labor and Welfare, Japan (nannti-ippann-044), and the Study Group for Strategic Exploration of Drug Seeds for ANCA-associated Vasculitis and Construction of Clinical Evidence from the Japan Agency for Medical Research and Development (16ek0109121h0002). A. Hara, MD, PhD, Department of Environmental and Preventive Medicine, Kanazawa University; T. Wada, MD, PhD, Department of Nephrology and Laboratory Medicine, Faculty of Medicine, Institute of Medical, Pharmaceutical and Health Sciences, Kanazawa University; K. Sada, MD, PhD, Department of Nephrology, Rheumatology, Endocrinology and Metabolism, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences; K. Amano, MD, PhD, Department of Rheumatology and Clinical Immunology, Saitama Medical Center; H. Dobashi, MD, PhD, Division of Endocrinology and Metabolism, Hematology, Rheumatology and Respiratory Medicine, Department of Internal Medicine, Faculty of Medicine, Kagawa University; M. Harigai, MD, PhD, Department of Pharmacovigilance, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University; Y. Takasaki, MD, PhD, Department of Internal Medicine and Rheumatology, Juntendo University School of Medicine; H. Yamada, MD, PhD, Division of Rheumatology and Allergology, Department of Internal Medicine, St. Marianna University School of Medicine; H. Hasegawa, MD, PhD, Department of Hematology, Clinical Immunology and Infectious Diseases, Ehime University Graduate School of Medicine; T. Hayashi, MD, PhD, Department of Rheumatology, Faculty of Medicine, University of Tsukuba; S. Fujimoto, MD, PhD, Department of Hemovascular Medicine and Artificial Organs, Faculty of Medicine, University of Miyazaki; E. Muso, MD, PhD, Center for Nephrology and Urology, Division of Nephrology and Dialysis, Kitano Hospital, Tazuke Kofukai Medical Research Institute; T. Kawakami, MD, PhD, Department of Dermatology, St. Marianna University School of Medicine; S. Homma, MD, PhD, Department of Respiratory Medicine, Toho University Omori Medical Center; M. Yoshida, MD, PhD, Division of Nephrology, Tokyo Medical University, Hachioji Medical Center; J. Hirahashi, MD, PhD, Department of Nephrology and Endocrinology, Graduate School of Medicine, The University of Tokyo; N. Ogawa, MD, PhD, Third Department of Internal Medicine, Division of Immunology and Rheumatology, Hamamatsu University School of Medicine; S. Ito, MD, PhD, Division of Rheumatology, Niigata Rheumatic Center; H. Makino, MD, PhD, Department of Nephrology, Rheumatology, Endocrinology and Metabolism, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences; Y. Arimura, MD, PhD, Nephrology and Rheumatology, First Department of Internal Medicine, Kyorin University School of Medicine. Address correspondence to Dr. T. Wada, Department of Nephrology and Laboratory Medicine, Institute of Medical, Pharmaceutical and Health Sciences, Faculty of Medicine, Kanazawa University, 13-1 Takara-machi, Kanazawa 920-8641, Japan. E-mail: twada@m-kanazawa.jp. Accepted for publication November 6, 2017.
Hidehiro Yamada
From the Department of Environmental and Preventive Medicine, and Department of Nephrology and Laboratory Medicine, Faculty of Medicine, Institute of Medical, Pharmaceutical and Health Sciences, Kanazawa University, Kanazawa; Department of Nephrology, Rheumatology, Endocrinology and Metabolism, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama; Department of Rheumatology and Clinical Immunology, Saitama Medical Center, Saitama; Division of Endocrinology and Metabolism, Hematology, Rheumatology and Respiratory Medicine, Department of Internal Medicine, Faculty of Medicine, Kagawa University, Kagawa; Division of Rheumatology and Allergology, Departments of Internal Medicine and Dermatology, St. Marianna University School of Medicine, Kawasaki; Department of Hematology, Clinical Immunology and Infectious Diseases, Ehime University Graduate School of Medicine, Matsuyama; Department of Rheumatology, Faculty of Medicine, University of Tsukuba, Tsukuba; Department of Hemovascular Medicine and Artificial Organs, Faculty of Medicine, University of Miyazaki, Miyazaki; Center for Nephrology and Urology, Division of Nephrology and Dialysis, Kitano Hospital, Tazuke Kofukai Medical Research Institute, Osaka; Third Department of Internal Medicine, Division of Immunology and Rheumatology, Hamamatsu University School of Medicine, Hamamatsu; Division of Rheumatology, Niigata Rheumatic Center, Shibata; Department of Pharmacovigilance, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University; Department of Internal Medicine and Rheumatology, Juntendo University School of Medicine; Department of Respiratory Medicine, Toho University Omori Medical Center; Division of Nephrology, Tokyo Medical University Hachioji Medical Center; Department of Nephrology and Endocrinology, Graduate School of Medicine, The University of Tokyo; Nephrology and Rheumatology, First Department of Internal Medicine, Kyorin University School of Medicine, Tokyo, Japan. Supported by grants for Research on Rare and Intractable Diseases, the Ministry of Health, Labor and Welfare, Japan (nannti-ippann-044), and the Study Group for Strategic Exploration of Drug Seeds for ANCA-associated Vasculitis and Construction of Clinical Evidence from the Japan Agency for Medical Research and Development (16ek0109121h0002). A. Hara, MD, PhD, Department of Environmental and Preventive Medicine, Kanazawa University; T. Wada, MD, PhD, Department of Nephrology and Laboratory Medicine, Faculty of Medicine, Institute of Medical, Pharmaceutical and Health Sciences, Kanazawa University; K. Sada, MD, PhD, Department of Nephrology, Rheumatology, Endocrinology and Metabolism, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences; K. Amano, MD, PhD, Department of Rheumatology and Clinical Immunology, Saitama Medical Center; H. Dobashi, MD, PhD, Division of Endocrinology and Metabolism, Hematology, Rheumatology and Respiratory Medicine, Department of Internal Medicine, Faculty of Medicine, Kagawa University; M. Harigai, MD, PhD, Department of Pharmacovigilance, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University; Y. Takasaki, MD, PhD, Department of Internal Medicine and Rheumatology, Juntendo University School of Medicine; H. Yamada, MD, PhD, Division of Rheumatology and Allergology, Department of Internal Medicine, St. Marianna University School of Medicine; H. Hasegawa, MD, PhD, Department of Hematology, Clinical Immunology and Infectious Diseases, Ehime University Graduate School of Medicine; T. Hayashi, MD, PhD, Department of Rheumatology, Faculty of Medicine, University of Tsukuba; S. Fujimoto, MD, PhD, Department of Hemovascular Medicine and Artificial Organs, Faculty of Medicine, University of Miyazaki; E. Muso, MD, PhD, Center for Nephrology and Urology, Division of Nephrology and Dialysis, Kitano Hospital, Tazuke Kofukai Medical Research Institute; T. Kawakami, MD, PhD, Department of Dermatology, St. Marianna University School of Medicine; S. Homma, MD, PhD, Department of Respiratory Medicine, Toho University Omori Medical Center; M. Yoshida, MD, PhD, Division of Nephrology, Tokyo Medical University, Hachioji Medical Center; J. Hirahashi, MD, PhD, Department of Nephrology and Endocrinology, Graduate School of Medicine, The University of Tokyo; N. Ogawa, MD, PhD, Third Department of Internal Medicine, Division of Immunology and Rheumatology, Hamamatsu University School of Medicine; S. Ito, MD, PhD, Division of Rheumatology, Niigata Rheumatic Center; H. Makino, MD, PhD, Department of Nephrology, Rheumatology, Endocrinology and Metabolism, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences; Y. Arimura, MD, PhD, Nephrology and Rheumatology, First Department of Internal Medicine, Kyorin University School of Medicine. Address correspondence to Dr. T. Wada, Department of Nephrology and Laboratory Medicine, Institute of Medical, Pharmaceutical and Health Sciences, Faculty of Medicine, Kanazawa University, 13-1 Takara-machi, Kanazawa 920-8641, Japan. E-mail: twada@m-kanazawa.jp. Accepted for publication November 6, 2017.
Hitoshi Hasegawa
From the Department of Environmental and Preventive Medicine, and Department of Nephrology and Laboratory Medicine, Faculty of Medicine, Institute of Medical, Pharmaceutical and Health Sciences, Kanazawa University, Kanazawa; Department of Nephrology, Rheumatology, Endocrinology and Metabolism, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama; Department of Rheumatology and Clinical Immunology, Saitama Medical Center, Saitama; Division of Endocrinology and Metabolism, Hematology, Rheumatology and Respiratory Medicine, Department of Internal Medicine, Faculty of Medicine, Kagawa University, Kagawa; Division of Rheumatology and Allergology, Departments of Internal Medicine and Dermatology, St. Marianna University School of Medicine, Kawasaki; Department of Hematology, Clinical Immunology and Infectious Diseases, Ehime University Graduate School of Medicine, Matsuyama; Department of Rheumatology, Faculty of Medicine, University of Tsukuba, Tsukuba; Department of Hemovascular Medicine and Artificial Organs, Faculty of Medicine, University of Miyazaki, Miyazaki; Center for Nephrology and Urology, Division of Nephrology and Dialysis, Kitano Hospital, Tazuke Kofukai Medical Research Institute, Osaka; Third Department of Internal Medicine, Division of Immunology and Rheumatology, Hamamatsu University School of Medicine, Hamamatsu; Division of Rheumatology, Niigata Rheumatic Center, Shibata; Department of Pharmacovigilance, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University; Department of Internal Medicine and Rheumatology, Juntendo University School of Medicine; Department of Respiratory Medicine, Toho University Omori Medical Center; Division of Nephrology, Tokyo Medical University Hachioji Medical Center; Department of Nephrology and Endocrinology, Graduate School of Medicine, The University of Tokyo; Nephrology and Rheumatology, First Department of Internal Medicine, Kyorin University School of Medicine, Tokyo, Japan. Supported by grants for Research on Rare and Intractable Diseases, the Ministry of Health, Labor and Welfare, Japan (nannti-ippann-044), and the Study Group for Strategic Exploration of Drug Seeds for ANCA-associated Vasculitis and Construction of Clinical Evidence from the Japan Agency for Medical Research and Development (16ek0109121h0002). A. Hara, MD, PhD, Department of Environmental and Preventive Medicine, Kanazawa University; T. Wada, MD, PhD, Department of Nephrology and Laboratory Medicine, Faculty of Medicine, Institute of Medical, Pharmaceutical and Health Sciences, Kanazawa University; K. Sada, MD, PhD, Department of Nephrology, Rheumatology, Endocrinology and Metabolism, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences; K. Amano, MD, PhD, Department of Rheumatology and Clinical Immunology, Saitama Medical Center; H. Dobashi, MD, PhD, Division of Endocrinology and Metabolism, Hematology, Rheumatology and Respiratory Medicine, Department of Internal Medicine, Faculty of Medicine, Kagawa University; M. Harigai, MD, PhD, Department of Pharmacovigilance, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University; Y. Takasaki, MD, PhD, Department of Internal Medicine and Rheumatology, Juntendo University School of Medicine; H. Yamada, MD, PhD, Division of Rheumatology and Allergology, Department of Internal Medicine, St. Marianna University School of Medicine; H. Hasegawa, MD, PhD, Department of Hematology, Clinical Immunology and Infectious Diseases, Ehime University Graduate School of Medicine; T. Hayashi, MD, PhD, Department of Rheumatology, Faculty of Medicine, University of Tsukuba; S. Fujimoto, MD, PhD, Department of Hemovascular Medicine and Artificial Organs, Faculty of Medicine, University of Miyazaki; E. Muso, MD, PhD, Center for Nephrology and Urology, Division of Nephrology and Dialysis, Kitano Hospital, Tazuke Kofukai Medical Research Institute; T. Kawakami, MD, PhD, Department of Dermatology, St. Marianna University School of Medicine; S. Homma, MD, PhD, Department of Respiratory Medicine, Toho University Omori Medical Center; M. Yoshida, MD, PhD, Division of Nephrology, Tokyo Medical University, Hachioji Medical Center; J. Hirahashi, MD, PhD, Department of Nephrology and Endocrinology, Graduate School of Medicine, The University of Tokyo; N. Ogawa, MD, PhD, Third Department of Internal Medicine, Division of Immunology and Rheumatology, Hamamatsu University School of Medicine; S. Ito, MD, PhD, Division of Rheumatology, Niigata Rheumatic Center; H. Makino, MD, PhD, Department of Nephrology, Rheumatology, Endocrinology and Metabolism, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences; Y. Arimura, MD, PhD, Nephrology and Rheumatology, First Department of Internal Medicine, Kyorin University School of Medicine. Address correspondence to Dr. T. Wada, Department of Nephrology and Laboratory Medicine, Institute of Medical, Pharmaceutical and Health Sciences, Faculty of Medicine, Kanazawa University, 13-1 Takara-machi, Kanazawa 920-8641, Japan. E-mail: twada@m-kanazawa.jp. Accepted for publication November 6, 2017.
Taichi Hayashi
From the Department of Environmental and Preventive Medicine, and Department of Nephrology and Laboratory Medicine, Faculty of Medicine, Institute of Medical, Pharmaceutical and Health Sciences, Kanazawa University, Kanazawa; Department of Nephrology, Rheumatology, Endocrinology and Metabolism, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama; Department of Rheumatology and Clinical Immunology, Saitama Medical Center, Saitama; Division of Endocrinology and Metabolism, Hematology, Rheumatology and Respiratory Medicine, Department of Internal Medicine, Faculty of Medicine, Kagawa University, Kagawa; Division of Rheumatology and Allergology, Departments of Internal Medicine and Dermatology, St. Marianna University School of Medicine, Kawasaki; Department of Hematology, Clinical Immunology and Infectious Diseases, Ehime University Graduate School of Medicine, Matsuyama; Department of Rheumatology, Faculty of Medicine, University of Tsukuba, Tsukuba; Department of Hemovascular Medicine and Artificial Organs, Faculty of Medicine, University of Miyazaki, Miyazaki; Center for Nephrology and Urology, Division of Nephrology and Dialysis, Kitano Hospital, Tazuke Kofukai Medical Research Institute, Osaka; Third Department of Internal Medicine, Division of Immunology and Rheumatology, Hamamatsu University School of Medicine, Hamamatsu; Division of Rheumatology, Niigata Rheumatic Center, Shibata; Department of Pharmacovigilance, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University; Department of Internal Medicine and Rheumatology, Juntendo University School of Medicine; Department of Respiratory Medicine, Toho University Omori Medical Center; Division of Nephrology, Tokyo Medical University Hachioji Medical Center; Department of Nephrology and Endocrinology, Graduate School of Medicine, The University of Tokyo; Nephrology and Rheumatology, First Department of Internal Medicine, Kyorin University School of Medicine, Tokyo, Japan. Supported by grants for Research on Rare and Intractable Diseases, the Ministry of Health, Labor and Welfare, Japan (nannti-ippann-044), and the Study Group for Strategic Exploration of Drug Seeds for ANCA-associated Vasculitis and Construction of Clinical Evidence from the Japan Agency for Medical Research and Development (16ek0109121h0002). A. Hara, MD, PhD, Department of Environmental and Preventive Medicine, Kanazawa University; T. Wada, MD, PhD, Department of Nephrology and Laboratory Medicine, Faculty of Medicine, Institute of Medical, Pharmaceutical and Health Sciences, Kanazawa University; K. Sada, MD, PhD, Department of Nephrology, Rheumatology, Endocrinology and Metabolism, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences; K. Amano, MD, PhD, Department of Rheumatology and Clinical Immunology, Saitama Medical Center; H. Dobashi, MD, PhD, Division of Endocrinology and Metabolism, Hematology, Rheumatology and Respiratory Medicine, Department of Internal Medicine, Faculty of Medicine, Kagawa University; M. Harigai, MD, PhD, Department of Pharmacovigilance, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University; Y. Takasaki, MD, PhD, Department of Internal Medicine and Rheumatology, Juntendo University School of Medicine; H. Yamada, MD, PhD, Division of Rheumatology and Allergology, Department of Internal Medicine, St. Marianna University School of Medicine; H. Hasegawa, MD, PhD, Department of Hematology, Clinical Immunology and Infectious Diseases, Ehime University Graduate School of Medicine; T. Hayashi, MD, PhD, Department of Rheumatology, Faculty of Medicine, University of Tsukuba; S. Fujimoto, MD, PhD, Department of Hemovascular Medicine and Artificial Organs, Faculty of Medicine, University of Miyazaki; E. Muso, MD, PhD, Center for Nephrology and Urology, Division of Nephrology and Dialysis, Kitano Hospital, Tazuke Kofukai Medical Research Institute; T. Kawakami, MD, PhD, Department of Dermatology, St. Marianna University School of Medicine; S. Homma, MD, PhD, Department of Respiratory Medicine, Toho University Omori Medical Center; M. Yoshida, MD, PhD, Division of Nephrology, Tokyo Medical University, Hachioji Medical Center; J. Hirahashi, MD, PhD, Department of Nephrology and Endocrinology, Graduate School of Medicine, The University of Tokyo; N. Ogawa, MD, PhD, Third Department of Internal Medicine, Division of Immunology and Rheumatology, Hamamatsu University School of Medicine; S. Ito, MD, PhD, Division of Rheumatology, Niigata Rheumatic Center; H. Makino, MD, PhD, Department of Nephrology, Rheumatology, Endocrinology and Metabolism, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences; Y. Arimura, MD, PhD, Nephrology and Rheumatology, First Department of Internal Medicine, Kyorin University School of Medicine. Address correspondence to Dr. T. Wada, Department of Nephrology and Laboratory Medicine, Institute of Medical, Pharmaceutical and Health Sciences, Faculty of Medicine, Kanazawa University, 13-1 Takara-machi, Kanazawa 920-8641, Japan. E-mail: twada@m-kanazawa.jp. Accepted for publication November 6, 2017.
Shouichi Fujimoto
From the Department of Environmental and Preventive Medicine, and Department of Nephrology and Laboratory Medicine, Faculty of Medicine, Institute of Medical, Pharmaceutical and Health Sciences, Kanazawa University, Kanazawa; Department of Nephrology, Rheumatology, Endocrinology and Metabolism, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama; Department of Rheumatology and Clinical Immunology, Saitama Medical Center, Saitama; Division of Endocrinology and Metabolism, Hematology, Rheumatology and Respiratory Medicine, Department of Internal Medicine, Faculty of Medicine, Kagawa University, Kagawa; Division of Rheumatology and Allergology, Departments of Internal Medicine and Dermatology, St. Marianna University School of Medicine, Kawasaki; Department of Hematology, Clinical Immunology and Infectious Diseases, Ehime University Graduate School of Medicine, Matsuyama; Department of Rheumatology, Faculty of Medicine, University of Tsukuba, Tsukuba; Department of Hemovascular Medicine and Artificial Organs, Faculty of Medicine, University of Miyazaki, Miyazaki; Center for Nephrology and Urology, Division of Nephrology and Dialysis, Kitano Hospital, Tazuke Kofukai Medical Research Institute, Osaka; Third Department of Internal Medicine, Division of Immunology and Rheumatology, Hamamatsu University School of Medicine, Hamamatsu; Division of Rheumatology, Niigata Rheumatic Center, Shibata; Department of Pharmacovigilance, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University; Department of Internal Medicine and Rheumatology, Juntendo University School of Medicine; Department of Respiratory Medicine, Toho University Omori Medical Center; Division of Nephrology, Tokyo Medical University Hachioji Medical Center; Department of Nephrology and Endocrinology, Graduate School of Medicine, The University of Tokyo; Nephrology and Rheumatology, First Department of Internal Medicine, Kyorin University School of Medicine, Tokyo, Japan. Supported by grants for Research on Rare and Intractable Diseases, the Ministry of Health, Labor and Welfare, Japan (nannti-ippann-044), and the Study Group for Strategic Exploration of Drug Seeds for ANCA-associated Vasculitis and Construction of Clinical Evidence from the Japan Agency for Medical Research and Development (16ek0109121h0002). A. Hara, MD, PhD, Department of Environmental and Preventive Medicine, Kanazawa University; T. Wada, MD, PhD, Department of Nephrology and Laboratory Medicine, Faculty of Medicine, Institute of Medical, Pharmaceutical and Health Sciences, Kanazawa University; K. Sada, MD, PhD, Department of Nephrology, Rheumatology, Endocrinology and Metabolism, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences; K. Amano, MD, PhD, Department of Rheumatology and Clinical Immunology, Saitama Medical Center; H. Dobashi, MD, PhD, Division of Endocrinology and Metabolism, Hematology, Rheumatology and Respiratory Medicine, Department of Internal Medicine, Faculty of Medicine, Kagawa University; M. Harigai, MD, PhD, Department of Pharmacovigilance, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University; Y. Takasaki, MD, PhD, Department of Internal Medicine and Rheumatology, Juntendo University School of Medicine; H. Yamada, MD, PhD, Division of Rheumatology and Allergology, Department of Internal Medicine, St. Marianna University School of Medicine; H. Hasegawa, MD, PhD, Department of Hematology, Clinical Immunology and Infectious Diseases, Ehime University Graduate School of Medicine; T. Hayashi, MD, PhD, Department of Rheumatology, Faculty of Medicine, University of Tsukuba; S. Fujimoto, MD, PhD, Department of Hemovascular Medicine and Artificial Organs, Faculty of Medicine, University of Miyazaki; E. Muso, MD, PhD, Center for Nephrology and Urology, Division of Nephrology and Dialysis, Kitano Hospital, Tazuke Kofukai Medical Research Institute; T. Kawakami, MD, PhD, Department of Dermatology, St. Marianna University School of Medicine; S. Homma, MD, PhD, Department of Respiratory Medicine, Toho University Omori Medical Center; M. Yoshida, MD, PhD, Division of Nephrology, Tokyo Medical University, Hachioji Medical Center; J. Hirahashi, MD, PhD, Department of Nephrology and Endocrinology, Graduate School of Medicine, The University of Tokyo; N. Ogawa, MD, PhD, Third Department of Internal Medicine, Division of Immunology and Rheumatology, Hamamatsu University School of Medicine; S. Ito, MD, PhD, Division of Rheumatology, Niigata Rheumatic Center; H. Makino, MD, PhD, Department of Nephrology, Rheumatology, Endocrinology and Metabolism, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences; Y. Arimura, MD, PhD, Nephrology and Rheumatology, First Department of Internal Medicine, Kyorin University School of Medicine. Address correspondence to Dr. T. Wada, Department of Nephrology and Laboratory Medicine, Institute of Medical, Pharmaceutical and Health Sciences, Faculty of Medicine, Kanazawa University, 13-1 Takara-machi, Kanazawa 920-8641, Japan. E-mail: twada@m-kanazawa.jp. Accepted for publication November 6, 2017.
Eri Muso
From the Department of Environmental and Preventive Medicine, and Department of Nephrology and Laboratory Medicine, Faculty of Medicine, Institute of Medical, Pharmaceutical and Health Sciences, Kanazawa University, Kanazawa; Department of Nephrology, Rheumatology, Endocrinology and Metabolism, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama; Department of Rheumatology and Clinical Immunology, Saitama Medical Center, Saitama; Division of Endocrinology and Metabolism, Hematology, Rheumatology and Respiratory Medicine, Department of Internal Medicine, Faculty of Medicine, Kagawa University, Kagawa; Division of Rheumatology and Allergology, Departments of Internal Medicine and Dermatology, St. Marianna University School of Medicine, Kawasaki; Department of Hematology, Clinical Immunology and Infectious Diseases, Ehime University Graduate School of Medicine, Matsuyama; Department of Rheumatology, Faculty of Medicine, University of Tsukuba, Tsukuba; Department of Hemovascular Medicine and Artificial Organs, Faculty of Medicine, University of Miyazaki, Miyazaki; Center for Nephrology and Urology, Division of Nephrology and Dialysis, Kitano Hospital, Tazuke Kofukai Medical Research Institute, Osaka; Third Department of Internal Medicine, Division of Immunology and Rheumatology, Hamamatsu University School of Medicine, Hamamatsu; Division of Rheumatology, Niigata Rheumatic Center, Shibata; Department of Pharmacovigilance, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University; Department of Internal Medicine and Rheumatology, Juntendo University School of Medicine; Department of Respiratory Medicine, Toho University Omori Medical Center; Division of Nephrology, Tokyo Medical University Hachioji Medical Center; Department of Nephrology and Endocrinology, Graduate School of Medicine, The University of Tokyo; Nephrology and Rheumatology, First Department of Internal Medicine, Kyorin University School of Medicine, Tokyo, Japan. Supported by grants for Research on Rare and Intractable Diseases, the Ministry of Health, Labor and Welfare, Japan (nannti-ippann-044), and the Study Group for Strategic Exploration of Drug Seeds for ANCA-associated Vasculitis and Construction of Clinical Evidence from the Japan Agency for Medical Research and Development (16ek0109121h0002). A. Hara, MD, PhD, Department of Environmental and Preventive Medicine, Kanazawa University; T. Wada, MD, PhD, Department of Nephrology and Laboratory Medicine, Faculty of Medicine, Institute of Medical, Pharmaceutical and Health Sciences, Kanazawa University; K. Sada, MD, PhD, Department of Nephrology, Rheumatology, Endocrinology and Metabolism, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences; K. Amano, MD, PhD, Department of Rheumatology and Clinical Immunology, Saitama Medical Center; H. Dobashi, MD, PhD, Division of Endocrinology and Metabolism, Hematology, Rheumatology and Respiratory Medicine, Department of Internal Medicine, Faculty of Medicine, Kagawa University; M. Harigai, MD, PhD, Department of Pharmacovigilance, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University; Y. Takasaki, MD, PhD, Department of Internal Medicine and Rheumatology, Juntendo University School of Medicine; H. Yamada, MD, PhD, Division of Rheumatology and Allergology, Department of Internal Medicine, St. Marianna University School of Medicine; H. Hasegawa, MD, PhD, Department of Hematology, Clinical Immunology and Infectious Diseases, Ehime University Graduate School of Medicine; T. Hayashi, MD, PhD, Department of Rheumatology, Faculty of Medicine, University of Tsukuba; S. Fujimoto, MD, PhD, Department of Hemovascular Medicine and Artificial Organs, Faculty of Medicine, University of Miyazaki; E. Muso, MD, PhD, Center for Nephrology and Urology, Division of Nephrology and Dialysis, Kitano Hospital, Tazuke Kofukai Medical Research Institute; T. Kawakami, MD, PhD, Department of Dermatology, St. Marianna University School of Medicine; S. Homma, MD, PhD, Department of Respiratory Medicine, Toho University Omori Medical Center; M. Yoshida, MD, PhD, Division of Nephrology, Tokyo Medical University, Hachioji Medical Center; J. Hirahashi, MD, PhD, Department of Nephrology and Endocrinology, Graduate School of Medicine, The University of Tokyo; N. Ogawa, MD, PhD, Third Department of Internal Medicine, Division of Immunology and Rheumatology, Hamamatsu University School of Medicine; S. Ito, MD, PhD, Division of Rheumatology, Niigata Rheumatic Center; H. Makino, MD, PhD, Department of Nephrology, Rheumatology, Endocrinology and Metabolism, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences; Y. Arimura, MD, PhD, Nephrology and Rheumatology, First Department of Internal Medicine, Kyorin University School of Medicine. Address correspondence to Dr. T. Wada, Department of Nephrology and Laboratory Medicine, Institute of Medical, Pharmaceutical and Health Sciences, Faculty of Medicine, Kanazawa University, 13-1 Takara-machi, Kanazawa 920-8641, Japan. E-mail: twada@m-kanazawa.jp. Accepted for publication November 6, 2017.
Tamihiro Kawakami
From the Department of Environmental and Preventive Medicine, and Department of Nephrology and Laboratory Medicine, Faculty of Medicine, Institute of Medical, Pharmaceutical and Health Sciences, Kanazawa University, Kanazawa; Department of Nephrology, Rheumatology, Endocrinology and Metabolism, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama; Department of Rheumatology and Clinical Immunology, Saitama Medical Center, Saitama; Division of Endocrinology and Metabolism, Hematology, Rheumatology and Respiratory Medicine, Department of Internal Medicine, Faculty of Medicine, Kagawa University, Kagawa; Division of Rheumatology and Allergology, Departments of Internal Medicine and Dermatology, St. Marianna University School of Medicine, Kawasaki; Department of Hematology, Clinical Immunology and Infectious Diseases, Ehime University Graduate School of Medicine, Matsuyama; Department of Rheumatology, Faculty of Medicine, University of Tsukuba, Tsukuba; Department of Hemovascular Medicine and Artificial Organs, Faculty of Medicine, University of Miyazaki, Miyazaki; Center for Nephrology and Urology, Division of Nephrology and Dialysis, Kitano Hospital, Tazuke Kofukai Medical Research Institute, Osaka; Third Department of Internal Medicine, Division of Immunology and Rheumatology, Hamamatsu University School of Medicine, Hamamatsu; Division of Rheumatology, Niigata Rheumatic Center, Shibata; Department of Pharmacovigilance, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University; Department of Internal Medicine and Rheumatology, Juntendo University School of Medicine; Department of Respiratory Medicine, Toho University Omori Medical Center; Division of Nephrology, Tokyo Medical University Hachioji Medical Center; Department of Nephrology and Endocrinology, Graduate School of Medicine, The University of Tokyo; Nephrology and Rheumatology, First Department of Internal Medicine, Kyorin University School of Medicine, Tokyo, Japan. Supported by grants for Research on Rare and Intractable Diseases, the Ministry of Health, Labor and Welfare, Japan (nannti-ippann-044), and the Study Group for Strategic Exploration of Drug Seeds for ANCA-associated Vasculitis and Construction of Clinical Evidence from the Japan Agency for Medical Research and Development (16ek0109121h0002). A. Hara, MD, PhD, Department of Environmental and Preventive Medicine, Kanazawa University; T. Wada, MD, PhD, Department of Nephrology and Laboratory Medicine, Faculty of Medicine, Institute of Medical, Pharmaceutical and Health Sciences, Kanazawa University; K. Sada, MD, PhD, Department of Nephrology, Rheumatology, Endocrinology and Metabolism, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences; K. Amano, MD, PhD, Department of Rheumatology and Clinical Immunology, Saitama Medical Center; H. Dobashi, MD, PhD, Division of Endocrinology and Metabolism, Hematology, Rheumatology and Respiratory Medicine, Department of Internal Medicine, Faculty of Medicine, Kagawa University; M. Harigai, MD, PhD, Department of Pharmacovigilance, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University; Y. Takasaki, MD, PhD, Department of Internal Medicine and Rheumatology, Juntendo University School of Medicine; H. Yamada, MD, PhD, Division of Rheumatology and Allergology, Department of Internal Medicine, St. Marianna University School of Medicine; H. Hasegawa, MD, PhD, Department of Hematology, Clinical Immunology and Infectious Diseases, Ehime University Graduate School of Medicine; T. Hayashi, MD, PhD, Department of Rheumatology, Faculty of Medicine, University of Tsukuba; S. Fujimoto, MD, PhD, Department of Hemovascular Medicine and Artificial Organs, Faculty of Medicine, University of Miyazaki; E. Muso, MD, PhD, Center for Nephrology and Urology, Division of Nephrology and Dialysis, Kitano Hospital, Tazuke Kofukai Medical Research Institute; T. Kawakami, MD, PhD, Department of Dermatology, St. Marianna University School of Medicine; S. Homma, MD, PhD, Department of Respiratory Medicine, Toho University Omori Medical Center; M. Yoshida, MD, PhD, Division of Nephrology, Tokyo Medical University, Hachioji Medical Center; J. Hirahashi, MD, PhD, Department of Nephrology and Endocrinology, Graduate School of Medicine, The University of Tokyo; N. Ogawa, MD, PhD, Third Department of Internal Medicine, Division of Immunology and Rheumatology, Hamamatsu University School of Medicine; S. Ito, MD, PhD, Division of Rheumatology, Niigata Rheumatic Center; H. Makino, MD, PhD, Department of Nephrology, Rheumatology, Endocrinology and Metabolism, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences; Y. Arimura, MD, PhD, Nephrology and Rheumatology, First Department of Internal Medicine, Kyorin University School of Medicine. Address correspondence to Dr. T. Wada, Department of Nephrology and Laboratory Medicine, Institute of Medical, Pharmaceutical and Health Sciences, Faculty of Medicine, Kanazawa University, 13-1 Takara-machi, Kanazawa 920-8641, Japan. E-mail: twada@m-kanazawa.jp. Accepted for publication November 6, 2017.
Sakae Homma
From the Department of Environmental and Preventive Medicine, and Department of Nephrology and Laboratory Medicine, Faculty of Medicine, Institute of Medical, Pharmaceutical and Health Sciences, Kanazawa University, Kanazawa; Department of Nephrology, Rheumatology, Endocrinology and Metabolism, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama; Department of Rheumatology and Clinical Immunology, Saitama Medical Center, Saitama; Division of Endocrinology and Metabolism, Hematology, Rheumatology and Respiratory Medicine, Department of Internal Medicine, Faculty of Medicine, Kagawa University, Kagawa; Division of Rheumatology and Allergology, Departments of Internal Medicine and Dermatology, St. Marianna University School of Medicine, Kawasaki; Department of Hematology, Clinical Immunology and Infectious Diseases, Ehime University Graduate School of Medicine, Matsuyama; Department of Rheumatology, Faculty of Medicine, University of Tsukuba, Tsukuba; Department of Hemovascular Medicine and Artificial Organs, Faculty of Medicine, University of Miyazaki, Miyazaki; Center for Nephrology and Urology, Division of Nephrology and Dialysis, Kitano Hospital, Tazuke Kofukai Medical Research Institute, Osaka; Third Department of Internal Medicine, Division of Immunology and Rheumatology, Hamamatsu University School of Medicine, Hamamatsu; Division of Rheumatology, Niigata Rheumatic Center, Shibata; Department of Pharmacovigilance, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University; Department of Internal Medicine and Rheumatology, Juntendo University School of Medicine; Department of Respiratory Medicine, Toho University Omori Medical Center; Division of Nephrology, Tokyo Medical University Hachioji Medical Center; Department of Nephrology and Endocrinology, Graduate School of Medicine, The University of Tokyo; Nephrology and Rheumatology, First Department of Internal Medicine, Kyorin University School of Medicine, Tokyo, Japan. Supported by grants for Research on Rare and Intractable Diseases, the Ministry of Health, Labor and Welfare, Japan (nannti-ippann-044), and the Study Group for Strategic Exploration of Drug Seeds for ANCA-associated Vasculitis and Construction of Clinical Evidence from the Japan Agency for Medical Research and Development (16ek0109121h0002). A. Hara, MD, PhD, Department of Environmental and Preventive Medicine, Kanazawa University; T. Wada, MD, PhD, Department of Nephrology and Laboratory Medicine, Faculty of Medicine, Institute of Medical, Pharmaceutical and Health Sciences, Kanazawa University; K. Sada, MD, PhD, Department of Nephrology, Rheumatology, Endocrinology and Metabolism, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences; K. Amano, MD, PhD, Department of Rheumatology and Clinical Immunology, Saitama Medical Center; H. Dobashi, MD, PhD, Division of Endocrinology and Metabolism, Hematology, Rheumatology and Respiratory Medicine, Department of Internal Medicine, Faculty of Medicine, Kagawa University; M. Harigai, MD, PhD, Department of Pharmacovigilance, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University; Y. Takasaki, MD, PhD, Department of Internal Medicine and Rheumatology, Juntendo University School of Medicine; H. Yamada, MD, PhD, Division of Rheumatology and Allergology, Department of Internal Medicine, St. Marianna University School of Medicine; H. Hasegawa, MD, PhD, Department of Hematology, Clinical Immunology and Infectious Diseases, Ehime University Graduate School of Medicine; T. Hayashi, MD, PhD, Department of Rheumatology, Faculty of Medicine, University of Tsukuba; S. Fujimoto, MD, PhD, Department of Hemovascular Medicine and Artificial Organs, Faculty of Medicine, University of Miyazaki; E. Muso, MD, PhD, Center for Nephrology and Urology, Division of Nephrology and Dialysis, Kitano Hospital, Tazuke Kofukai Medical Research Institute; T. Kawakami, MD, PhD, Department of Dermatology, St. Marianna University School of Medicine; S. Homma, MD, PhD, Department of Respiratory Medicine, Toho University Omori Medical Center; M. Yoshida, MD, PhD, Division of Nephrology, Tokyo Medical University, Hachioji Medical Center; J. Hirahashi, MD, PhD, Department of Nephrology and Endocrinology, Graduate School of Medicine, The University of Tokyo; N. Ogawa, MD, PhD, Third Department of Internal Medicine, Division of Immunology and Rheumatology, Hamamatsu University School of Medicine; S. Ito, MD, PhD, Division of Rheumatology, Niigata Rheumatic Center; H. Makino, MD, PhD, Department of Nephrology, Rheumatology, Endocrinology and Metabolism, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences; Y. Arimura, MD, PhD, Nephrology and Rheumatology, First Department of Internal Medicine, Kyorin University School of Medicine. Address correspondence to Dr. T. Wada, Department of Nephrology and Laboratory Medicine, Institute of Medical, Pharmaceutical and Health Sciences, Faculty of Medicine, Kanazawa University, 13-1 Takara-machi, Kanazawa 920-8641, Japan. E-mail: twada@m-kanazawa.jp. Accepted for publication November 6, 2017.
Masaharu Yoshida
From the Department of Environmental and Preventive Medicine, and Department of Nephrology and Laboratory Medicine, Faculty of Medicine, Institute of Medical, Pharmaceutical and Health Sciences, Kanazawa University, Kanazawa; Department of Nephrology, Rheumatology, Endocrinology and Metabolism, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama; Department of Rheumatology and Clinical Immunology, Saitama Medical Center, Saitama; Division of Endocrinology and Metabolism, Hematology, Rheumatology and Respiratory Medicine, Department of Internal Medicine, Faculty of Medicine, Kagawa University, Kagawa; Division of Rheumatology and Allergology, Departments of Internal Medicine and Dermatology, St. Marianna University School of Medicine, Kawasaki; Department of Hematology, Clinical Immunology and Infectious Diseases, Ehime University Graduate School of Medicine, Matsuyama; Department of Rheumatology, Faculty of Medicine, University of Tsukuba, Tsukuba; Department of Hemovascular Medicine and Artificial Organs, Faculty of Medicine, University of Miyazaki, Miyazaki; Center for Nephrology and Urology, Division of Nephrology and Dialysis, Kitano Hospital, Tazuke Kofukai Medical Research Institute, Osaka; Third Department of Internal Medicine, Division of Immunology and Rheumatology, Hamamatsu University School of Medicine, Hamamatsu; Division of Rheumatology, Niigata Rheumatic Center, Shibata; Department of Pharmacovigilance, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University; Department of Internal Medicine and Rheumatology, Juntendo University School of Medicine; Department of Respiratory Medicine, Toho University Omori Medical Center; Division of Nephrology, Tokyo Medical University Hachioji Medical Center; Department of Nephrology and Endocrinology, Graduate School of Medicine, The University of Tokyo; Nephrology and Rheumatology, First Department of Internal Medicine, Kyorin University School of Medicine, Tokyo, Japan. Supported by grants for Research on Rare and Intractable Diseases, the Ministry of Health, Labor and Welfare, Japan (nannti-ippann-044), and the Study Group for Strategic Exploration of Drug Seeds for ANCA-associated Vasculitis and Construction of Clinical Evidence from the Japan Agency for Medical Research and Development (16ek0109121h0002). A. Hara, MD, PhD, Department of Environmental and Preventive Medicine, Kanazawa University; T. Wada, MD, PhD, Department of Nephrology and Laboratory Medicine, Faculty of Medicine, Institute of Medical, Pharmaceutical and Health Sciences, Kanazawa University; K. Sada, MD, PhD, Department of Nephrology, Rheumatology, Endocrinology and Metabolism, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences; K. Amano, MD, PhD, Department of Rheumatology and Clinical Immunology, Saitama Medical Center; H. Dobashi, MD, PhD, Division of Endocrinology and Metabolism, Hematology, Rheumatology and Respiratory Medicine, Department of Internal Medicine, Faculty of Medicine, Kagawa University; M. Harigai, MD, PhD, Department of Pharmacovigilance, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University; Y. Takasaki, MD, PhD, Department of Internal Medicine and Rheumatology, Juntendo University School of Medicine; H. Yamada, MD, PhD, Division of Rheumatology and Allergology, Department of Internal Medicine, St. Marianna University School of Medicine; H. Hasegawa, MD, PhD, Department of Hematology, Clinical Immunology and Infectious Diseases, Ehime University Graduate School of Medicine; T. Hayashi, MD, PhD, Department of Rheumatology, Faculty of Medicine, University of Tsukuba; S. Fujimoto, MD, PhD, Department of Hemovascular Medicine and Artificial Organs, Faculty of Medicine, University of Miyazaki; E. Muso, MD, PhD, Center for Nephrology and Urology, Division of Nephrology and Dialysis, Kitano Hospital, Tazuke Kofukai Medical Research Institute; T. Kawakami, MD, PhD, Department of Dermatology, St. Marianna University School of Medicine; S. Homma, MD, PhD, Department of Respiratory Medicine, Toho University Omori Medical Center; M. Yoshida, MD, PhD, Division of Nephrology, Tokyo Medical University, Hachioji Medical Center; J. Hirahashi, MD, PhD, Department of Nephrology and Endocrinology, Graduate School of Medicine, The University of Tokyo; N. Ogawa, MD, PhD, Third Department of Internal Medicine, Division of Immunology and Rheumatology, Hamamatsu University School of Medicine; S. Ito, MD, PhD, Division of Rheumatology, Niigata Rheumatic Center; H. Makino, MD, PhD, Department of Nephrology, Rheumatology, Endocrinology and Metabolism, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences; Y. Arimura, MD, PhD, Nephrology and Rheumatology, First Department of Internal Medicine, Kyorin University School of Medicine. Address correspondence to Dr. T. Wada, Department of Nephrology and Laboratory Medicine, Institute of Medical, Pharmaceutical and Health Sciences, Faculty of Medicine, Kanazawa University, 13-1 Takara-machi, Kanazawa 920-8641, Japan. E-mail: twada@m-kanazawa.jp. Accepted for publication November 6, 2017.
Junichi Hirahashi
From the Department of Environmental and Preventive Medicine, and Department of Nephrology and Laboratory Medicine, Faculty of Medicine, Institute of Medical, Pharmaceutical and Health Sciences, Kanazawa University, Kanazawa; Department of Nephrology, Rheumatology, Endocrinology and Metabolism, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama; Department of Rheumatology and Clinical Immunology, Saitama Medical Center, Saitama; Division of Endocrinology and Metabolism, Hematology, Rheumatology and Respiratory Medicine, Department of Internal Medicine, Faculty of Medicine, Kagawa University, Kagawa; Division of Rheumatology and Allergology, Departments of Internal Medicine and Dermatology, St. Marianna University School of Medicine, Kawasaki; Department of Hematology, Clinical Immunology and Infectious Diseases, Ehime University Graduate School of Medicine, Matsuyama; Department of Rheumatology, Faculty of Medicine, University of Tsukuba, Tsukuba; Department of Hemovascular Medicine and Artificial Organs, Faculty of Medicine, University of Miyazaki, Miyazaki; Center for Nephrology and Urology, Division of Nephrology and Dialysis, Kitano Hospital, Tazuke Kofukai Medical Research Institute, Osaka; Third Department of Internal Medicine, Division of Immunology and Rheumatology, Hamamatsu University School of Medicine, Hamamatsu; Division of Rheumatology, Niigata Rheumatic Center, Shibata; Department of Pharmacovigilance, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University; Department of Internal Medicine and Rheumatology, Juntendo University School of Medicine; Department of Respiratory Medicine, Toho University Omori Medical Center; Division of Nephrology, Tokyo Medical University Hachioji Medical Center; Department of Nephrology and Endocrinology, Graduate School of Medicine, The University of Tokyo; Nephrology and Rheumatology, First Department of Internal Medicine, Kyorin University School of Medicine, Tokyo, Japan. Supported by grants for Research on Rare and Intractable Diseases, the Ministry of Health, Labor and Welfare, Japan (nannti-ippann-044), and the Study Group for Strategic Exploration of Drug Seeds for ANCA-associated Vasculitis and Construction of Clinical Evidence from the Japan Agency for Medical Research and Development (16ek0109121h0002). A. Hara, MD, PhD, Department of Environmental and Preventive Medicine, Kanazawa University; T. Wada, MD, PhD, Department of Nephrology and Laboratory Medicine, Faculty of Medicine, Institute of Medical, Pharmaceutical and Health Sciences, Kanazawa University; K. Sada, MD, PhD, Department of Nephrology, Rheumatology, Endocrinology and Metabolism, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences; K. Amano, MD, PhD, Department of Rheumatology and Clinical Immunology, Saitama Medical Center; H. Dobashi, MD, PhD, Division of Endocrinology and Metabolism, Hematology, Rheumatology and Respiratory Medicine, Department of Internal Medicine, Faculty of Medicine, Kagawa University; M. Harigai, MD, PhD, Department of Pharmacovigilance, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University; Y. Takasaki, MD, PhD, Department of Internal Medicine and Rheumatology, Juntendo University School of Medicine; H. Yamada, MD, PhD, Division of Rheumatology and Allergology, Department of Internal Medicine, St. Marianna University School of Medicine; H. Hasegawa, MD, PhD, Department of Hematology, Clinical Immunology and Infectious Diseases, Ehime University Graduate School of Medicine; T. Hayashi, MD, PhD, Department of Rheumatology, Faculty of Medicine, University of Tsukuba; S. Fujimoto, MD, PhD, Department of Hemovascular Medicine and Artificial Organs, Faculty of Medicine, University of Miyazaki; E. Muso, MD, PhD, Center for Nephrology and Urology, Division of Nephrology and Dialysis, Kitano Hospital, Tazuke Kofukai Medical Research Institute; T. Kawakami, MD, PhD, Department of Dermatology, St. Marianna University School of Medicine; S. Homma, MD, PhD, Department of Respiratory Medicine, Toho University Omori Medical Center; M. Yoshida, MD, PhD, Division of Nephrology, Tokyo Medical University, Hachioji Medical Center; J. Hirahashi, MD, PhD, Department of Nephrology and Endocrinology, Graduate School of Medicine, The University of Tokyo; N. Ogawa, MD, PhD, Third Department of Internal Medicine, Division of Immunology and Rheumatology, Hamamatsu University School of Medicine; S. Ito, MD, PhD, Division of Rheumatology, Niigata Rheumatic Center; H. Makino, MD, PhD, Department of Nephrology, Rheumatology, Endocrinology and Metabolism, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences; Y. Arimura, MD, PhD, Nephrology and Rheumatology, First Department of Internal Medicine, Kyorin University School of Medicine. Address correspondence to Dr. T. Wada, Department of Nephrology and Laboratory Medicine, Institute of Medical, Pharmaceutical and Health Sciences, Faculty of Medicine, Kanazawa University, 13-1 Takara-machi, Kanazawa 920-8641, Japan. E-mail: twada@m-kanazawa.jp. Accepted for publication November 6, 2017.
Noriyoshi Ogawa
From the Department of Environmental and Preventive Medicine, and Department of Nephrology and Laboratory Medicine, Faculty of Medicine, Institute of Medical, Pharmaceutical and Health Sciences, Kanazawa University, Kanazawa; Department of Nephrology, Rheumatology, Endocrinology and Metabolism, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama; Department of Rheumatology and Clinical Immunology, Saitama Medical Center, Saitama; Division of Endocrinology and Metabolism, Hematology, Rheumatology and Respiratory Medicine, Department of Internal Medicine, Faculty of Medicine, Kagawa University, Kagawa; Division of Rheumatology and Allergology, Departments of Internal Medicine and Dermatology, St. Marianna University School of Medicine, Kawasaki; Department of Hematology, Clinical Immunology and Infectious Diseases, Ehime University Graduate School of Medicine, Matsuyama; Department of Rheumatology, Faculty of Medicine, University of Tsukuba, Tsukuba; Department of Hemovascular Medicine and Artificial Organs, Faculty of Medicine, University of Miyazaki, Miyazaki; Center for Nephrology and Urology, Division of Nephrology and Dialysis, Kitano Hospital, Tazuke Kofukai Medical Research Institute, Osaka; Third Department of Internal Medicine, Division of Immunology and Rheumatology, Hamamatsu University School of Medicine, Hamamatsu; Division of Rheumatology, Niigata Rheumatic Center, Shibata; Department of Pharmacovigilance, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University; Department of Internal Medicine and Rheumatology, Juntendo University School of Medicine; Department of Respiratory Medicine, Toho University Omori Medical Center; Division of Nephrology, Tokyo Medical University Hachioji Medical Center; Department of Nephrology and Endocrinology, Graduate School of Medicine, The University of Tokyo; Nephrology and Rheumatology, First Department of Internal Medicine, Kyorin University School of Medicine, Tokyo, Japan. Supported by grants for Research on Rare and Intractable Diseases, the Ministry of Health, Labor and Welfare, Japan (nannti-ippann-044), and the Study Group for Strategic Exploration of Drug Seeds for ANCA-associated Vasculitis and Construction of Clinical Evidence from the Japan Agency for Medical Research and Development (16ek0109121h0002). A. Hara, MD, PhD, Department of Environmental and Preventive Medicine, Kanazawa University; T. Wada, MD, PhD, Department of Nephrology and Laboratory Medicine, Faculty of Medicine, Institute of Medical, Pharmaceutical and Health Sciences, Kanazawa University; K. Sada, MD, PhD, Department of Nephrology, Rheumatology, Endocrinology and Metabolism, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences; K. Amano, MD, PhD, Department of Rheumatology and Clinical Immunology, Saitama Medical Center; H. Dobashi, MD, PhD, Division of Endocrinology and Metabolism, Hematology, Rheumatology and Respiratory Medicine, Department of Internal Medicine, Faculty of Medicine, Kagawa University; M. Harigai, MD, PhD, Department of Pharmacovigilance, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University; Y. Takasaki, MD, PhD, Department of Internal Medicine and Rheumatology, Juntendo University School of Medicine; H. Yamada, MD, PhD, Division of Rheumatology and Allergology, Department of Internal Medicine, St. Marianna University School of Medicine; H. Hasegawa, MD, PhD, Department of Hematology, Clinical Immunology and Infectious Diseases, Ehime University Graduate School of Medicine; T. Hayashi, MD, PhD, Department of Rheumatology, Faculty of Medicine, University of Tsukuba; S. Fujimoto, MD, PhD, Department of Hemovascular Medicine and Artificial Organs, Faculty of Medicine, University of Miyazaki; E. Muso, MD, PhD, Center for Nephrology and Urology, Division of Nephrology and Dialysis, Kitano Hospital, Tazuke Kofukai Medical Research Institute; T. Kawakami, MD, PhD, Department of Dermatology, St. Marianna University School of Medicine; S. Homma, MD, PhD, Department of Respiratory Medicine, Toho University Omori Medical Center; M. Yoshida, MD, PhD, Division of Nephrology, Tokyo Medical University, Hachioji Medical Center; J. Hirahashi, MD, PhD, Department of Nephrology and Endocrinology, Graduate School of Medicine, The University of Tokyo; N. Ogawa, MD, PhD, Third Department of Internal Medicine, Division of Immunology and Rheumatology, Hamamatsu University School of Medicine; S. Ito, MD, PhD, Division of Rheumatology, Niigata Rheumatic Center; H. Makino, MD, PhD, Department of Nephrology, Rheumatology, Endocrinology and Metabolism, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences; Y. Arimura, MD, PhD, Nephrology and Rheumatology, First Department of Internal Medicine, Kyorin University School of Medicine. Address correspondence to Dr. T. Wada, Department of Nephrology and Laboratory Medicine, Institute of Medical, Pharmaceutical and Health Sciences, Faculty of Medicine, Kanazawa University, 13-1 Takara-machi, Kanazawa 920-8641, Japan. E-mail: twada@m-kanazawa.jp. Accepted for publication November 6, 2017.
Satoshi Ito
From the Department of Environmental and Preventive Medicine, and Department of Nephrology and Laboratory Medicine, Faculty of Medicine, Institute of Medical, Pharmaceutical and Health Sciences, Kanazawa University, Kanazawa; Department of Nephrology, Rheumatology, Endocrinology and Metabolism, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama; Department of Rheumatology and Clinical Immunology, Saitama Medical Center, Saitama; Division of Endocrinology and Metabolism, Hematology, Rheumatology and Respiratory Medicine, Department of Internal Medicine, Faculty of Medicine, Kagawa University, Kagawa; Division of Rheumatology and Allergology, Departments of Internal Medicine and Dermatology, St. Marianna University School of Medicine, Kawasaki; Department of Hematology, Clinical Immunology and Infectious Diseases, Ehime University Graduate School of Medicine, Matsuyama; Department of Rheumatology, Faculty of Medicine, University of Tsukuba, Tsukuba; Department of Hemovascular Medicine and Artificial Organs, Faculty of Medicine, University of Miyazaki, Miyazaki; Center for Nephrology and Urology, Division of Nephrology and Dialysis, Kitano Hospital, Tazuke Kofukai Medical Research Institute, Osaka; Third Department of Internal Medicine, Division of Immunology and Rheumatology, Hamamatsu University School of Medicine, Hamamatsu; Division of Rheumatology, Niigata Rheumatic Center, Shibata; Department of Pharmacovigilance, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University; Department of Internal Medicine and Rheumatology, Juntendo University School of Medicine; Department of Respiratory Medicine, Toho University Omori Medical Center; Division of Nephrology, Tokyo Medical University Hachioji Medical Center; Department of Nephrology and Endocrinology, Graduate School of Medicine, The University of Tokyo; Nephrology and Rheumatology, First Department of Internal Medicine, Kyorin University School of Medicine, Tokyo, Japan. Supported by grants for Research on Rare and Intractable Diseases, the Ministry of Health, Labor and Welfare, Japan (nannti-ippann-044), and the Study Group for Strategic Exploration of Drug Seeds for ANCA-associated Vasculitis and Construction of Clinical Evidence from the Japan Agency for Medical Research and Development (16ek0109121h0002). A. Hara, MD, PhD, Department of Environmental and Preventive Medicine, Kanazawa University; T. Wada, MD, PhD, Department of Nephrology and Laboratory Medicine, Faculty of Medicine, Institute of Medical, Pharmaceutical and Health Sciences, Kanazawa University; K. Sada, MD, PhD, Department of Nephrology, Rheumatology, Endocrinology and Metabolism, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences; K. Amano, MD, PhD, Department of Rheumatology and Clinical Immunology, Saitama Medical Center; H. Dobashi, MD, PhD, Division of Endocrinology and Metabolism, Hematology, Rheumatology and Respiratory Medicine, Department of Internal Medicine, Faculty of Medicine, Kagawa University; M. Harigai, MD, PhD, Department of Pharmacovigilance, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University; Y. Takasaki, MD, PhD, Department of Internal Medicine and Rheumatology, Juntendo University School of Medicine; H. Yamada, MD, PhD, Division of Rheumatology and Allergology, Department of Internal Medicine, St. Marianna University School of Medicine; H. Hasegawa, MD, PhD, Department of Hematology, Clinical Immunology and Infectious Diseases, Ehime University Graduate School of Medicine; T. Hayashi, MD, PhD, Department of Rheumatology, Faculty of Medicine, University of Tsukuba; S. Fujimoto, MD, PhD, Department of Hemovascular Medicine and Artificial Organs, Faculty of Medicine, University of Miyazaki; E. Muso, MD, PhD, Center for Nephrology and Urology, Division of Nephrology and Dialysis, Kitano Hospital, Tazuke Kofukai Medical Research Institute; T. Kawakami, MD, PhD, Department of Dermatology, St. Marianna University School of Medicine; S. Homma, MD, PhD, Department of Respiratory Medicine, Toho University Omori Medical Center; M. Yoshida, MD, PhD, Division of Nephrology, Tokyo Medical University, Hachioji Medical Center; J. Hirahashi, MD, PhD, Department of Nephrology and Endocrinology, Graduate School of Medicine, The University of Tokyo; N. Ogawa, MD, PhD, Third Department of Internal Medicine, Division of Immunology and Rheumatology, Hamamatsu University School of Medicine; S. Ito, MD, PhD, Division of Rheumatology, Niigata Rheumatic Center; H. Makino, MD, PhD, Department of Nephrology, Rheumatology, Endocrinology and Metabolism, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences; Y. Arimura, MD, PhD, Nephrology and Rheumatology, First Department of Internal Medicine, Kyorin University School of Medicine. Address correspondence to Dr. T. Wada, Department of Nephrology and Laboratory Medicine, Institute of Medical, Pharmaceutical and Health Sciences, Faculty of Medicine, Kanazawa University, 13-1 Takara-machi, Kanazawa 920-8641, Japan. E-mail: twada@m-kanazawa.jp. Accepted for publication November 6, 2017.
Hirofumi Makino
From the Department of Environmental and Preventive Medicine, and Department of Nephrology and Laboratory Medicine, Faculty of Medicine, Institute of Medical, Pharmaceutical and Health Sciences, Kanazawa University, Kanazawa; Department of Nephrology, Rheumatology, Endocrinology and Metabolism, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama; Department of Rheumatology and Clinical Immunology, Saitama Medical Center, Saitama; Division of Endocrinology and Metabolism, Hematology, Rheumatology and Respiratory Medicine, Department of Internal Medicine, Faculty of Medicine, Kagawa University, Kagawa; Division of Rheumatology and Allergology, Departments of Internal Medicine and Dermatology, St. Marianna University School of Medicine, Kawasaki; Department of Hematology, Clinical Immunology and Infectious Diseases, Ehime University Graduate School of Medicine, Matsuyama; Department of Rheumatology, Faculty of Medicine, University of Tsukuba, Tsukuba; Department of Hemovascular Medicine and Artificial Organs, Faculty of Medicine, University of Miyazaki, Miyazaki; Center for Nephrology and Urology, Division of Nephrology and Dialysis, Kitano Hospital, Tazuke Kofukai Medical Research Institute, Osaka; Third Department of Internal Medicine, Division of Immunology and Rheumatology, Hamamatsu University School of Medicine, Hamamatsu; Division of Rheumatology, Niigata Rheumatic Center, Shibata; Department of Pharmacovigilance, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University; Department of Internal Medicine and Rheumatology, Juntendo University School of Medicine; Department of Respiratory Medicine, Toho University Omori Medical Center; Division of Nephrology, Tokyo Medical University Hachioji Medical Center; Department of Nephrology and Endocrinology, Graduate School of Medicine, The University of Tokyo; Nephrology and Rheumatology, First Department of Internal Medicine, Kyorin University School of Medicine, Tokyo, Japan. Supported by grants for Research on Rare and Intractable Diseases, the Ministry of Health, Labor and Welfare, Japan (nannti-ippann-044), and the Study Group for Strategic Exploration of Drug Seeds for ANCA-associated Vasculitis and Construction of Clinical Evidence from the Japan Agency for Medical Research and Development (16ek0109121h0002). A. Hara, MD, PhD, Department of Environmental and Preventive Medicine, Kanazawa University; T. Wada, MD, PhD, Department of Nephrology and Laboratory Medicine, Faculty of Medicine, Institute of Medical, Pharmaceutical and Health Sciences, Kanazawa University; K. Sada, MD, PhD, Department of Nephrology, Rheumatology, Endocrinology and Metabolism, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences; K. Amano, MD, PhD, Department of Rheumatology and Clinical Immunology, Saitama Medical Center; H. Dobashi, MD, PhD, Division of Endocrinology and Metabolism, Hematology, Rheumatology and Respiratory Medicine, Department of Internal Medicine, Faculty of Medicine, Kagawa University; M. Harigai, MD, PhD, Department of Pharmacovigilance, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University; Y. Takasaki, MD, PhD, Department of Internal Medicine and Rheumatology, Juntendo University School of Medicine; H. Yamada, MD, PhD, Division of Rheumatology and Allergology, Department of Internal Medicine, St. Marianna University School of Medicine; H. Hasegawa, MD, PhD, Department of Hematology, Clinical Immunology and Infectious Diseases, Ehime University Graduate School of Medicine; T. Hayashi, MD, PhD, Department of Rheumatology, Faculty of Medicine, University of Tsukuba; S. Fujimoto, MD, PhD, Department of Hemovascular Medicine and Artificial Organs, Faculty of Medicine, University of Miyazaki; E. Muso, MD, PhD, Center for Nephrology and Urology, Division of Nephrology and Dialysis, Kitano Hospital, Tazuke Kofukai Medical Research Institute; T. Kawakami, MD, PhD, Department of Dermatology, St. Marianna University School of Medicine; S. Homma, MD, PhD, Department of Respiratory Medicine, Toho University Omori Medical Center; M. Yoshida, MD, PhD, Division of Nephrology, Tokyo Medical University, Hachioji Medical Center; J. Hirahashi, MD, PhD, Department of Nephrology and Endocrinology, Graduate School of Medicine, The University of Tokyo; N. Ogawa, MD, PhD, Third Department of Internal Medicine, Division of Immunology and Rheumatology, Hamamatsu University School of Medicine; S. Ito, MD, PhD, Division of Rheumatology, Niigata Rheumatic Center; H. Makino, MD, PhD, Department of Nephrology, Rheumatology, Endocrinology and Metabolism, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences; Y. Arimura, MD, PhD, Nephrology and Rheumatology, First Department of Internal Medicine, Kyorin University School of Medicine. Address correspondence to Dr. T. Wada, Department of Nephrology and Laboratory Medicine, Institute of Medical, Pharmaceutical and Health Sciences, Faculty of Medicine, Kanazawa University, 13-1 Takara-machi, Kanazawa 920-8641, Japan. E-mail: twada@m-kanazawa.jp. Accepted for publication November 6, 2017.
Yoshihiro Arimura
From the Department of Environmental and Preventive Medicine, and Department of Nephrology and Laboratory Medicine, Faculty of Medicine, Institute of Medical, Pharmaceutical and Health Sciences, Kanazawa University, Kanazawa; Department of Nephrology, Rheumatology, Endocrinology and Metabolism, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama; Department of Rheumatology and Clinical Immunology, Saitama Medical Center, Saitama; Division of Endocrinology and Metabolism, Hematology, Rheumatology and Respiratory Medicine, Department of Internal Medicine, Faculty of Medicine, Kagawa University, Kagawa; Division of Rheumatology and Allergology, Departments of Internal Medicine and Dermatology, St. Marianna University School of Medicine, Kawasaki; Department of Hematology, Clinical Immunology and Infectious Diseases, Ehime University Graduate School of Medicine, Matsuyama; Department of Rheumatology, Faculty of Medicine, University of Tsukuba, Tsukuba; Department of Hemovascular Medicine and Artificial Organs, Faculty of Medicine, University of Miyazaki, Miyazaki; Center for Nephrology and Urology, Division of Nephrology and Dialysis, Kitano Hospital, Tazuke Kofukai Medical Research Institute, Osaka; Third Department of Internal Medicine, Division of Immunology and Rheumatology, Hamamatsu University School of Medicine, Hamamatsu; Division of Rheumatology, Niigata Rheumatic Center, Shibata; Department of Pharmacovigilance, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University; Department of Internal Medicine and Rheumatology, Juntendo University School of Medicine; Department of Respiratory Medicine, Toho University Omori Medical Center; Division of Nephrology, Tokyo Medical University Hachioji Medical Center; Department of Nephrology and Endocrinology, Graduate School of Medicine, The University of Tokyo; Nephrology and Rheumatology, First Department of Internal Medicine, Kyorin University School of Medicine, Tokyo, Japan. Supported by grants for Research on Rare and Intractable Diseases, the Ministry of Health, Labor and Welfare, Japan (nannti-ippann-044), and the Study Group for Strategic Exploration of Drug Seeds for ANCA-associated Vasculitis and Construction of Clinical Evidence from the Japan Agency for Medical Research and Development (16ek0109121h0002). A. Hara, MD, PhD, Department of Environmental and Preventive Medicine, Kanazawa University; T. Wada, MD, PhD, Department of Nephrology and Laboratory Medicine, Faculty of Medicine, Institute of Medical, Pharmaceutical and Health Sciences, Kanazawa University; K. Sada, MD, PhD, Department of Nephrology, Rheumatology, Endocrinology and Metabolism, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences; K. Amano, MD, PhD, Department of Rheumatology and Clinical Immunology, Saitama Medical Center; H. Dobashi, MD, PhD, Division of Endocrinology and Metabolism, Hematology, Rheumatology and Respiratory Medicine, Department of Internal Medicine, Faculty of Medicine, Kagawa University; M. Harigai, MD, PhD, Department of Pharmacovigilance, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University; Y. Takasaki, MD, PhD, Department of Internal Medicine and Rheumatology, Juntendo University School of Medicine; H. Yamada, MD, PhD, Division of Rheumatology and Allergology, Department of Internal Medicine, St. Marianna University School of Medicine; H. Hasegawa, MD, PhD, Department of Hematology, Clinical Immunology and Infectious Diseases, Ehime University Graduate School of Medicine; T. Hayashi, MD, PhD, Department of Rheumatology, Faculty of Medicine, University of Tsukuba; S. Fujimoto, MD, PhD, Department of Hemovascular Medicine and Artificial Organs, Faculty of Medicine, University of Miyazaki; E. Muso, MD, PhD, Center for Nephrology and Urology, Division of Nephrology and Dialysis, Kitano Hospital, Tazuke Kofukai Medical Research Institute; T. Kawakami, MD, PhD, Department of Dermatology, St. Marianna University School of Medicine; S. Homma, MD, PhD, Department of Respiratory Medicine, Toho University Omori Medical Center; M. Yoshida, MD, PhD, Division of Nephrology, Tokyo Medical University, Hachioji Medical Center; J. Hirahashi, MD, PhD, Department of Nephrology and Endocrinology, Graduate School of Medicine, The University of Tokyo; N. Ogawa, MD, PhD, Third Department of Internal Medicine, Division of Immunology and Rheumatology, Hamamatsu University School of Medicine; S. Ito, MD, PhD, Division of Rheumatology, Niigata Rheumatic Center; H. Makino, MD, PhD, Department of Nephrology, Rheumatology, Endocrinology and Metabolism, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences; Y. Arimura, MD, PhD, Nephrology and Rheumatology, First Department of Internal Medicine, Kyorin University School of Medicine. Address correspondence to Dr. T. Wada, Department of Nephrology and Laboratory Medicine, Institute of Medical, Pharmaceutical and Health Sciences, Faculty of Medicine, Kanazawa University, 13-1 Takara-machi, Kanazawa 920-8641, Japan. E-mail: twada@m-kanazawa.jp. Accepted for publication November 6, 2017.
In this issue
The Journal of Rheumatology
Vol. 51, Issue 4
1 Apr 2024
Risk Factors for Relapse of Antineutrophil Cytoplasmic Antibody-associated Vasculitis in Japan: A Nationwide, Prospective Cohort Study
Akinori Hara, Takashi Wada, Ken-ei Sada, Koichi Amano, Hiroaki Dobashi, Masayoshi Harigai, Yoshinari Takasaki, Hidehiro Yamada, Hitoshi Hasegawa, Taichi Hayashi, Shouichi Fujimoto, Eri Muso, Tamihiro Kawakami, Sakae Homma, Masaharu Yoshida, Junichi Hirahashi, Noriyoshi Ogawa, Satoshi Ito, Hirofumi Makino, Yoshihiro Arimura
The Journal of Rheumatology Feb 2018, jrheum.170508; DOI: 10.3899/jrheum.170508
Risk Factors for Relapse of Antineutrophil Cytoplasmic Antibody-associated Vasculitis in Japan: A Nationwide, Prospective Cohort Study
Akinori Hara, Takashi Wada, Ken-ei Sada, Koichi Amano, Hiroaki Dobashi, Masayoshi Harigai, Yoshinari Takasaki, Hidehiro Yamada, Hitoshi Hasegawa, Taichi Hayashi, Shouichi Fujimoto, Eri Muso, Tamihiro Kawakami, Sakae Homma, Masaharu Yoshida, Junichi Hirahashi, Noriyoshi Ogawa, Satoshi Ito, Hirofumi Makino, Yoshihiro Arimura
The Journal of Rheumatology Feb 2018, jrheum.170508; DOI: 10.3899/jrheum.170508