Research ArticleArticle
Efficacy of Continuous Interleukin 1 Blockade in Mevalonate Kinase Deficiency: A Multicenter Retrospective Study in 13 Adult Patients and Literature Review
Samuel Deshayes, Sophie Georgin-Lavialle, Arnaud Hot, Cécile-Audrey Durel, Eric Hachulla, Nicolas Rouanes, Sylvain Audia, Thomas Le Gallou, Pierre Quartier, Geoffrey Urbanski, Laurent Messer, Stéphane Klein, Hubert de Boysson, Boris Bienvenu, Gilles Grateau and Achille Aouba
The Journal of Rheumatology January 2018, jrheum.170684; DOI: https://doi.org/10.3899/jrheum.170684
Samuel Deshayes
From the Department of Internal Medicine, Université Caen Normandie, Medical School, CHU de Caen, Caen; Department of Internal Medicine, Tenon Hospital, University Pierre and Marie Curie-Paris 6; Department of Pediatric Immunology, Hematology and Rheumatology, Hôpital Necker, Paris; Department of Internal Medicine, Edouard Herriot Hospital, Lyon; Department of Internal Medicine, Claude Huriez Hospital, University of Lille, Lille; Department of Internal Medicine, CH de Périgueux, Périgueux; Department of Internal Medicine and Clinical Immunology, CHU de Dijon, Dijon; Department of Internal Medicine, CHU de Rennes, Rennes; Department of Internal Medicine and Vascular Diseases, CHU d’Angers, Angers; Department of Rheumatology, CH de Colmar, Colmar, France. S. Deshayes, MD, CHU de Caen, Department of Internal Medicine, Université Caen Normandie, Medical School; S. Georgin-Lavialle, MD, PhD, Tenon Hospital, Department of Internal Medicine, University Pierre and Marie Curie-Paris 6; A. Hot, MD, PhD, Edouard Herriot Hospital, Department of Internal Medicine; C.A. Durel, MD, Edouard Herriot Hospital, Department of Internal Medicine; E. Hachulla, MD, PhD, Claude Huriez Hospital, Department of Internal Medicine, University of Lille; N. Rouanes, MD, CH de Périgueux, Department of Internal Medicine; S. Audia, MD, PhD, CHU de Dijon, Department of Internal Medicine and Clinical Immunology; T. Le Gallou, MD, CHU de Rennes, Department of Internal Medicine; P. Quartier, MD, PhD, Hôpital Necker, Department of Pediatric Immunology, Hematology and Rheumatology; G. Urbanski, MD, CHU d’Angers, Department of Internal Medicine and Vascular Diseases; L. Messer, MD, CH de Colmar, Department of Rheumatology; S. Klein, MD, CHU de Caen, Department of Internal Medicine, Université Caen Normandie, Medical School; H. de Boysson, MD, CHU de Caen, Department of Internal Medicine, Université Caen Normandie, Medical School; B. Bienvenu, MD, PhD, CHU de Caen, Department of Internal Medicine, Université Caen Normandie, Medical School; G. Grateau, MD, PhD, Tenon Hospital, Department of Internal Medicine, University Pierre and Marie Curie-Paris 6; A. Aouba, MD, PhD, CHU de Caen, Department of Internal Medicine, Université Caen Normandie, Medical School. Address correspondence to Dr. A. Aouba, Department of Internal Medicine and Clinical Immunology, CHU Côte de Nacre, Université Basse Normandie, Avenue de la Côte de Nacre, 14000 Caen, France. E-mail: aouba-a@chu-caen.fr. Accepted for publication November 15, 2017.
Sophie Georgin-Lavialle
From the Department of Internal Medicine, Université Caen Normandie, Medical School, CHU de Caen, Caen; Department of Internal Medicine, Tenon Hospital, University Pierre and Marie Curie-Paris 6; Department of Pediatric Immunology, Hematology and Rheumatology, Hôpital Necker, Paris; Department of Internal Medicine, Edouard Herriot Hospital, Lyon; Department of Internal Medicine, Claude Huriez Hospital, University of Lille, Lille; Department of Internal Medicine, CH de Périgueux, Périgueux; Department of Internal Medicine and Clinical Immunology, CHU de Dijon, Dijon; Department of Internal Medicine, CHU de Rennes, Rennes; Department of Internal Medicine and Vascular Diseases, CHU d’Angers, Angers; Department of Rheumatology, CH de Colmar, Colmar, France. S. Deshayes, MD, CHU de Caen, Department of Internal Medicine, Université Caen Normandie, Medical School; S. Georgin-Lavialle, MD, PhD, Tenon Hospital, Department of Internal Medicine, University Pierre and Marie Curie-Paris 6; A. Hot, MD, PhD, Edouard Herriot Hospital, Department of Internal Medicine; C.A. Durel, MD, Edouard Herriot Hospital, Department of Internal Medicine; E. Hachulla, MD, PhD, Claude Huriez Hospital, Department of Internal Medicine, University of Lille; N. Rouanes, MD, CH de Périgueux, Department of Internal Medicine; S. Audia, MD, PhD, CHU de Dijon, Department of Internal Medicine and Clinical Immunology; T. Le Gallou, MD, CHU de Rennes, Department of Internal Medicine; P. Quartier, MD, PhD, Hôpital Necker, Department of Pediatric Immunology, Hematology and Rheumatology; G. Urbanski, MD, CHU d’Angers, Department of Internal Medicine and Vascular Diseases; L. Messer, MD, CH de Colmar, Department of Rheumatology; S. Klein, MD, CHU de Caen, Department of Internal Medicine, Université Caen Normandie, Medical School; H. de Boysson, MD, CHU de Caen, Department of Internal Medicine, Université Caen Normandie, Medical School; B. Bienvenu, MD, PhD, CHU de Caen, Department of Internal Medicine, Université Caen Normandie, Medical School; G. Grateau, MD, PhD, Tenon Hospital, Department of Internal Medicine, University Pierre and Marie Curie-Paris 6; A. Aouba, MD, PhD, CHU de Caen, Department of Internal Medicine, Université Caen Normandie, Medical School. Address correspondence to Dr. A. Aouba, Department of Internal Medicine and Clinical Immunology, CHU Côte de Nacre, Université Basse Normandie, Avenue de la Côte de Nacre, 14000 Caen, France. E-mail: aouba-a@chu-caen.fr. Accepted for publication November 15, 2017.
Arnaud Hot
From the Department of Internal Medicine, Université Caen Normandie, Medical School, CHU de Caen, Caen; Department of Internal Medicine, Tenon Hospital, University Pierre and Marie Curie-Paris 6; Department of Pediatric Immunology, Hematology and Rheumatology, Hôpital Necker, Paris; Department of Internal Medicine, Edouard Herriot Hospital, Lyon; Department of Internal Medicine, Claude Huriez Hospital, University of Lille, Lille; Department of Internal Medicine, CH de Périgueux, Périgueux; Department of Internal Medicine and Clinical Immunology, CHU de Dijon, Dijon; Department of Internal Medicine, CHU de Rennes, Rennes; Department of Internal Medicine and Vascular Diseases, CHU d’Angers, Angers; Department of Rheumatology, CH de Colmar, Colmar, France. S. Deshayes, MD, CHU de Caen, Department of Internal Medicine, Université Caen Normandie, Medical School; S. Georgin-Lavialle, MD, PhD, Tenon Hospital, Department of Internal Medicine, University Pierre and Marie Curie-Paris 6; A. Hot, MD, PhD, Edouard Herriot Hospital, Department of Internal Medicine; C.A. Durel, MD, Edouard Herriot Hospital, Department of Internal Medicine; E. Hachulla, MD, PhD, Claude Huriez Hospital, Department of Internal Medicine, University of Lille; N. Rouanes, MD, CH de Périgueux, Department of Internal Medicine; S. Audia, MD, PhD, CHU de Dijon, Department of Internal Medicine and Clinical Immunology; T. Le Gallou, MD, CHU de Rennes, Department of Internal Medicine; P. Quartier, MD, PhD, Hôpital Necker, Department of Pediatric Immunology, Hematology and Rheumatology; G. Urbanski, MD, CHU d’Angers, Department of Internal Medicine and Vascular Diseases; L. Messer, MD, CH de Colmar, Department of Rheumatology; S. Klein, MD, CHU de Caen, Department of Internal Medicine, Université Caen Normandie, Medical School; H. de Boysson, MD, CHU de Caen, Department of Internal Medicine, Université Caen Normandie, Medical School; B. Bienvenu, MD, PhD, CHU de Caen, Department of Internal Medicine, Université Caen Normandie, Medical School; G. Grateau, MD, PhD, Tenon Hospital, Department of Internal Medicine, University Pierre and Marie Curie-Paris 6; A. Aouba, MD, PhD, CHU de Caen, Department of Internal Medicine, Université Caen Normandie, Medical School. Address correspondence to Dr. A. Aouba, Department of Internal Medicine and Clinical Immunology, CHU Côte de Nacre, Université Basse Normandie, Avenue de la Côte de Nacre, 14000 Caen, France. E-mail: aouba-a@chu-caen.fr. Accepted for publication November 15, 2017.
Cécile-Audrey Durel
From the Department of Internal Medicine, Université Caen Normandie, Medical School, CHU de Caen, Caen; Department of Internal Medicine, Tenon Hospital, University Pierre and Marie Curie-Paris 6; Department of Pediatric Immunology, Hematology and Rheumatology, Hôpital Necker, Paris; Department of Internal Medicine, Edouard Herriot Hospital, Lyon; Department of Internal Medicine, Claude Huriez Hospital, University of Lille, Lille; Department of Internal Medicine, CH de Périgueux, Périgueux; Department of Internal Medicine and Clinical Immunology, CHU de Dijon, Dijon; Department of Internal Medicine, CHU de Rennes, Rennes; Department of Internal Medicine and Vascular Diseases, CHU d’Angers, Angers; Department of Rheumatology, CH de Colmar, Colmar, France. S. Deshayes, MD, CHU de Caen, Department of Internal Medicine, Université Caen Normandie, Medical School; S. Georgin-Lavialle, MD, PhD, Tenon Hospital, Department of Internal Medicine, University Pierre and Marie Curie-Paris 6; A. Hot, MD, PhD, Edouard Herriot Hospital, Department of Internal Medicine; C.A. Durel, MD, Edouard Herriot Hospital, Department of Internal Medicine; E. Hachulla, MD, PhD, Claude Huriez Hospital, Department of Internal Medicine, University of Lille; N. Rouanes, MD, CH de Périgueux, Department of Internal Medicine; S. Audia, MD, PhD, CHU de Dijon, Department of Internal Medicine and Clinical Immunology; T. Le Gallou, MD, CHU de Rennes, Department of Internal Medicine; P. Quartier, MD, PhD, Hôpital Necker, Department of Pediatric Immunology, Hematology and Rheumatology; G. Urbanski, MD, CHU d’Angers, Department of Internal Medicine and Vascular Diseases; L. Messer, MD, CH de Colmar, Department of Rheumatology; S. Klein, MD, CHU de Caen, Department of Internal Medicine, Université Caen Normandie, Medical School; H. de Boysson, MD, CHU de Caen, Department of Internal Medicine, Université Caen Normandie, Medical School; B. Bienvenu, MD, PhD, CHU de Caen, Department of Internal Medicine, Université Caen Normandie, Medical School; G. Grateau, MD, PhD, Tenon Hospital, Department of Internal Medicine, University Pierre and Marie Curie-Paris 6; A. Aouba, MD, PhD, CHU de Caen, Department of Internal Medicine, Université Caen Normandie, Medical School. Address correspondence to Dr. A. Aouba, Department of Internal Medicine and Clinical Immunology, CHU Côte de Nacre, Université Basse Normandie, Avenue de la Côte de Nacre, 14000 Caen, France. E-mail: aouba-a@chu-caen.fr. Accepted for publication November 15, 2017.
Eric Hachulla
From the Department of Internal Medicine, Université Caen Normandie, Medical School, CHU de Caen, Caen; Department of Internal Medicine, Tenon Hospital, University Pierre and Marie Curie-Paris 6; Department of Pediatric Immunology, Hematology and Rheumatology, Hôpital Necker, Paris; Department of Internal Medicine, Edouard Herriot Hospital, Lyon; Department of Internal Medicine, Claude Huriez Hospital, University of Lille, Lille; Department of Internal Medicine, CH de Périgueux, Périgueux; Department of Internal Medicine and Clinical Immunology, CHU de Dijon, Dijon; Department of Internal Medicine, CHU de Rennes, Rennes; Department of Internal Medicine and Vascular Diseases, CHU d’Angers, Angers; Department of Rheumatology, CH de Colmar, Colmar, France. S. Deshayes, MD, CHU de Caen, Department of Internal Medicine, Université Caen Normandie, Medical School; S. Georgin-Lavialle, MD, PhD, Tenon Hospital, Department of Internal Medicine, University Pierre and Marie Curie-Paris 6; A. Hot, MD, PhD, Edouard Herriot Hospital, Department of Internal Medicine; C.A. Durel, MD, Edouard Herriot Hospital, Department of Internal Medicine; E. Hachulla, MD, PhD, Claude Huriez Hospital, Department of Internal Medicine, University of Lille; N. Rouanes, MD, CH de Périgueux, Department of Internal Medicine; S. Audia, MD, PhD, CHU de Dijon, Department of Internal Medicine and Clinical Immunology; T. Le Gallou, MD, CHU de Rennes, Department of Internal Medicine; P. Quartier, MD, PhD, Hôpital Necker, Department of Pediatric Immunology, Hematology and Rheumatology; G. Urbanski, MD, CHU d’Angers, Department of Internal Medicine and Vascular Diseases; L. Messer, MD, CH de Colmar, Department of Rheumatology; S. Klein, MD, CHU de Caen, Department of Internal Medicine, Université Caen Normandie, Medical School; H. de Boysson, MD, CHU de Caen, Department of Internal Medicine, Université Caen Normandie, Medical School; B. Bienvenu, MD, PhD, CHU de Caen, Department of Internal Medicine, Université Caen Normandie, Medical School; G. Grateau, MD, PhD, Tenon Hospital, Department of Internal Medicine, University Pierre and Marie Curie-Paris 6; A. Aouba, MD, PhD, CHU de Caen, Department of Internal Medicine, Université Caen Normandie, Medical School. Address correspondence to Dr. A. Aouba, Department of Internal Medicine and Clinical Immunology, CHU Côte de Nacre, Université Basse Normandie, Avenue de la Côte de Nacre, 14000 Caen, France. E-mail: aouba-a@chu-caen.fr. Accepted for publication November 15, 2017.
Nicolas Rouanes
From the Department of Internal Medicine, Université Caen Normandie, Medical School, CHU de Caen, Caen; Department of Internal Medicine, Tenon Hospital, University Pierre and Marie Curie-Paris 6; Department of Pediatric Immunology, Hematology and Rheumatology, Hôpital Necker, Paris; Department of Internal Medicine, Edouard Herriot Hospital, Lyon; Department of Internal Medicine, Claude Huriez Hospital, University of Lille, Lille; Department of Internal Medicine, CH de Périgueux, Périgueux; Department of Internal Medicine and Clinical Immunology, CHU de Dijon, Dijon; Department of Internal Medicine, CHU de Rennes, Rennes; Department of Internal Medicine and Vascular Diseases, CHU d’Angers, Angers; Department of Rheumatology, CH de Colmar, Colmar, France. S. Deshayes, MD, CHU de Caen, Department of Internal Medicine, Université Caen Normandie, Medical School; S. Georgin-Lavialle, MD, PhD, Tenon Hospital, Department of Internal Medicine, University Pierre and Marie Curie-Paris 6; A. Hot, MD, PhD, Edouard Herriot Hospital, Department of Internal Medicine; C.A. Durel, MD, Edouard Herriot Hospital, Department of Internal Medicine; E. Hachulla, MD, PhD, Claude Huriez Hospital, Department of Internal Medicine, University of Lille; N. Rouanes, MD, CH de Périgueux, Department of Internal Medicine; S. Audia, MD, PhD, CHU de Dijon, Department of Internal Medicine and Clinical Immunology; T. Le Gallou, MD, CHU de Rennes, Department of Internal Medicine; P. Quartier, MD, PhD, Hôpital Necker, Department of Pediatric Immunology, Hematology and Rheumatology; G. Urbanski, MD, CHU d’Angers, Department of Internal Medicine and Vascular Diseases; L. Messer, MD, CH de Colmar, Department of Rheumatology; S. Klein, MD, CHU de Caen, Department of Internal Medicine, Université Caen Normandie, Medical School; H. de Boysson, MD, CHU de Caen, Department of Internal Medicine, Université Caen Normandie, Medical School; B. Bienvenu, MD, PhD, CHU de Caen, Department of Internal Medicine, Université Caen Normandie, Medical School; G. Grateau, MD, PhD, Tenon Hospital, Department of Internal Medicine, University Pierre and Marie Curie-Paris 6; A. Aouba, MD, PhD, CHU de Caen, Department of Internal Medicine, Université Caen Normandie, Medical School. Address correspondence to Dr. A. Aouba, Department of Internal Medicine and Clinical Immunology, CHU Côte de Nacre, Université Basse Normandie, Avenue de la Côte de Nacre, 14000 Caen, France. E-mail: aouba-a@chu-caen.fr. Accepted for publication November 15, 2017.
Sylvain Audia
From the Department of Internal Medicine, Université Caen Normandie, Medical School, CHU de Caen, Caen; Department of Internal Medicine, Tenon Hospital, University Pierre and Marie Curie-Paris 6; Department of Pediatric Immunology, Hematology and Rheumatology, Hôpital Necker, Paris; Department of Internal Medicine, Edouard Herriot Hospital, Lyon; Department of Internal Medicine, Claude Huriez Hospital, University of Lille, Lille; Department of Internal Medicine, CH de Périgueux, Périgueux; Department of Internal Medicine and Clinical Immunology, CHU de Dijon, Dijon; Department of Internal Medicine, CHU de Rennes, Rennes; Department of Internal Medicine and Vascular Diseases, CHU d’Angers, Angers; Department of Rheumatology, CH de Colmar, Colmar, France. S. Deshayes, MD, CHU de Caen, Department of Internal Medicine, Université Caen Normandie, Medical School; S. Georgin-Lavialle, MD, PhD, Tenon Hospital, Department of Internal Medicine, University Pierre and Marie Curie-Paris 6; A. Hot, MD, PhD, Edouard Herriot Hospital, Department of Internal Medicine; C.A. Durel, MD, Edouard Herriot Hospital, Department of Internal Medicine; E. Hachulla, MD, PhD, Claude Huriez Hospital, Department of Internal Medicine, University of Lille; N. Rouanes, MD, CH de Périgueux, Department of Internal Medicine; S. Audia, MD, PhD, CHU de Dijon, Department of Internal Medicine and Clinical Immunology; T. Le Gallou, MD, CHU de Rennes, Department of Internal Medicine; P. Quartier, MD, PhD, Hôpital Necker, Department of Pediatric Immunology, Hematology and Rheumatology; G. Urbanski, MD, CHU d’Angers, Department of Internal Medicine and Vascular Diseases; L. Messer, MD, CH de Colmar, Department of Rheumatology; S. Klein, MD, CHU de Caen, Department of Internal Medicine, Université Caen Normandie, Medical School; H. de Boysson, MD, CHU de Caen, Department of Internal Medicine, Université Caen Normandie, Medical School; B. Bienvenu, MD, PhD, CHU de Caen, Department of Internal Medicine, Université Caen Normandie, Medical School; G. Grateau, MD, PhD, Tenon Hospital, Department of Internal Medicine, University Pierre and Marie Curie-Paris 6; A. Aouba, MD, PhD, CHU de Caen, Department of Internal Medicine, Université Caen Normandie, Medical School. Address correspondence to Dr. A. Aouba, Department of Internal Medicine and Clinical Immunology, CHU Côte de Nacre, Université Basse Normandie, Avenue de la Côte de Nacre, 14000 Caen, France. E-mail: aouba-a@chu-caen.fr. Accepted for publication November 15, 2017.
Thomas Le Gallou
From the Department of Internal Medicine, Université Caen Normandie, Medical School, CHU de Caen, Caen; Department of Internal Medicine, Tenon Hospital, University Pierre and Marie Curie-Paris 6; Department of Pediatric Immunology, Hematology and Rheumatology, Hôpital Necker, Paris; Department of Internal Medicine, Edouard Herriot Hospital, Lyon; Department of Internal Medicine, Claude Huriez Hospital, University of Lille, Lille; Department of Internal Medicine, CH de Périgueux, Périgueux; Department of Internal Medicine and Clinical Immunology, CHU de Dijon, Dijon; Department of Internal Medicine, CHU de Rennes, Rennes; Department of Internal Medicine and Vascular Diseases, CHU d’Angers, Angers; Department of Rheumatology, CH de Colmar, Colmar, France. S. Deshayes, MD, CHU de Caen, Department of Internal Medicine, Université Caen Normandie, Medical School; S. Georgin-Lavialle, MD, PhD, Tenon Hospital, Department of Internal Medicine, University Pierre and Marie Curie-Paris 6; A. Hot, MD, PhD, Edouard Herriot Hospital, Department of Internal Medicine; C.A. Durel, MD, Edouard Herriot Hospital, Department of Internal Medicine; E. Hachulla, MD, PhD, Claude Huriez Hospital, Department of Internal Medicine, University of Lille; N. Rouanes, MD, CH de Périgueux, Department of Internal Medicine; S. Audia, MD, PhD, CHU de Dijon, Department of Internal Medicine and Clinical Immunology; T. Le Gallou, MD, CHU de Rennes, Department of Internal Medicine; P. Quartier, MD, PhD, Hôpital Necker, Department of Pediatric Immunology, Hematology and Rheumatology; G. Urbanski, MD, CHU d’Angers, Department of Internal Medicine and Vascular Diseases; L. Messer, MD, CH de Colmar, Department of Rheumatology; S. Klein, MD, CHU de Caen, Department of Internal Medicine, Université Caen Normandie, Medical School; H. de Boysson, MD, CHU de Caen, Department of Internal Medicine, Université Caen Normandie, Medical School; B. Bienvenu, MD, PhD, CHU de Caen, Department of Internal Medicine, Université Caen Normandie, Medical School; G. Grateau, MD, PhD, Tenon Hospital, Department of Internal Medicine, University Pierre and Marie Curie-Paris 6; A. Aouba, MD, PhD, CHU de Caen, Department of Internal Medicine, Université Caen Normandie, Medical School. Address correspondence to Dr. A. Aouba, Department of Internal Medicine and Clinical Immunology, CHU Côte de Nacre, Université Basse Normandie, Avenue de la Côte de Nacre, 14000 Caen, France. E-mail: aouba-a@chu-caen.fr. Accepted for publication November 15, 2017.
Pierre Quartier
From the Department of Internal Medicine, Université Caen Normandie, Medical School, CHU de Caen, Caen; Department of Internal Medicine, Tenon Hospital, University Pierre and Marie Curie-Paris 6; Department of Pediatric Immunology, Hematology and Rheumatology, Hôpital Necker, Paris; Department of Internal Medicine, Edouard Herriot Hospital, Lyon; Department of Internal Medicine, Claude Huriez Hospital, University of Lille, Lille; Department of Internal Medicine, CH de Périgueux, Périgueux; Department of Internal Medicine and Clinical Immunology, CHU de Dijon, Dijon; Department of Internal Medicine, CHU de Rennes, Rennes; Department of Internal Medicine and Vascular Diseases, CHU d’Angers, Angers; Department of Rheumatology, CH de Colmar, Colmar, France. S. Deshayes, MD, CHU de Caen, Department of Internal Medicine, Université Caen Normandie, Medical School; S. Georgin-Lavialle, MD, PhD, Tenon Hospital, Department of Internal Medicine, University Pierre and Marie Curie-Paris 6; A. Hot, MD, PhD, Edouard Herriot Hospital, Department of Internal Medicine; C.A. Durel, MD, Edouard Herriot Hospital, Department of Internal Medicine; E. Hachulla, MD, PhD, Claude Huriez Hospital, Department of Internal Medicine, University of Lille; N. Rouanes, MD, CH de Périgueux, Department of Internal Medicine; S. Audia, MD, PhD, CHU de Dijon, Department of Internal Medicine and Clinical Immunology; T. Le Gallou, MD, CHU de Rennes, Department of Internal Medicine; P. Quartier, MD, PhD, Hôpital Necker, Department of Pediatric Immunology, Hematology and Rheumatology; G. Urbanski, MD, CHU d’Angers, Department of Internal Medicine and Vascular Diseases; L. Messer, MD, CH de Colmar, Department of Rheumatology; S. Klein, MD, CHU de Caen, Department of Internal Medicine, Université Caen Normandie, Medical School; H. de Boysson, MD, CHU de Caen, Department of Internal Medicine, Université Caen Normandie, Medical School; B. Bienvenu, MD, PhD, CHU de Caen, Department of Internal Medicine, Université Caen Normandie, Medical School; G. Grateau, MD, PhD, Tenon Hospital, Department of Internal Medicine, University Pierre and Marie Curie-Paris 6; A. Aouba, MD, PhD, CHU de Caen, Department of Internal Medicine, Université Caen Normandie, Medical School. Address correspondence to Dr. A. Aouba, Department of Internal Medicine and Clinical Immunology, CHU Côte de Nacre, Université Basse Normandie, Avenue de la Côte de Nacre, 14000 Caen, France. E-mail: aouba-a@chu-caen.fr. Accepted for publication November 15, 2017.
Geoffrey Urbanski
From the Department of Internal Medicine, Université Caen Normandie, Medical School, CHU de Caen, Caen; Department of Internal Medicine, Tenon Hospital, University Pierre and Marie Curie-Paris 6; Department of Pediatric Immunology, Hematology and Rheumatology, Hôpital Necker, Paris; Department of Internal Medicine, Edouard Herriot Hospital, Lyon; Department of Internal Medicine, Claude Huriez Hospital, University of Lille, Lille; Department of Internal Medicine, CH de Périgueux, Périgueux; Department of Internal Medicine and Clinical Immunology, CHU de Dijon, Dijon; Department of Internal Medicine, CHU de Rennes, Rennes; Department of Internal Medicine and Vascular Diseases, CHU d’Angers, Angers; Department of Rheumatology, CH de Colmar, Colmar, France. S. Deshayes, MD, CHU de Caen, Department of Internal Medicine, Université Caen Normandie, Medical School; S. Georgin-Lavialle, MD, PhD, Tenon Hospital, Department of Internal Medicine, University Pierre and Marie Curie-Paris 6; A. Hot, MD, PhD, Edouard Herriot Hospital, Department of Internal Medicine; C.A. Durel, MD, Edouard Herriot Hospital, Department of Internal Medicine; E. Hachulla, MD, PhD, Claude Huriez Hospital, Department of Internal Medicine, University of Lille; N. Rouanes, MD, CH de Périgueux, Department of Internal Medicine; S. Audia, MD, PhD, CHU de Dijon, Department of Internal Medicine and Clinical Immunology; T. Le Gallou, MD, CHU de Rennes, Department of Internal Medicine; P. Quartier, MD, PhD, Hôpital Necker, Department of Pediatric Immunology, Hematology and Rheumatology; G. Urbanski, MD, CHU d’Angers, Department of Internal Medicine and Vascular Diseases; L. Messer, MD, CH de Colmar, Department of Rheumatology; S. Klein, MD, CHU de Caen, Department of Internal Medicine, Université Caen Normandie, Medical School; H. de Boysson, MD, CHU de Caen, Department of Internal Medicine, Université Caen Normandie, Medical School; B. Bienvenu, MD, PhD, CHU de Caen, Department of Internal Medicine, Université Caen Normandie, Medical School; G. Grateau, MD, PhD, Tenon Hospital, Department of Internal Medicine, University Pierre and Marie Curie-Paris 6; A. Aouba, MD, PhD, CHU de Caen, Department of Internal Medicine, Université Caen Normandie, Medical School. Address correspondence to Dr. A. Aouba, Department of Internal Medicine and Clinical Immunology, CHU Côte de Nacre, Université Basse Normandie, Avenue de la Côte de Nacre, 14000 Caen, France. E-mail: aouba-a@chu-caen.fr. Accepted for publication November 15, 2017.
Laurent Messer
From the Department of Internal Medicine, Université Caen Normandie, Medical School, CHU de Caen, Caen; Department of Internal Medicine, Tenon Hospital, University Pierre and Marie Curie-Paris 6; Department of Pediatric Immunology, Hematology and Rheumatology, Hôpital Necker, Paris; Department of Internal Medicine, Edouard Herriot Hospital, Lyon; Department of Internal Medicine, Claude Huriez Hospital, University of Lille, Lille; Department of Internal Medicine, CH de Périgueux, Périgueux; Department of Internal Medicine and Clinical Immunology, CHU de Dijon, Dijon; Department of Internal Medicine, CHU de Rennes, Rennes; Department of Internal Medicine and Vascular Diseases, CHU d’Angers, Angers; Department of Rheumatology, CH de Colmar, Colmar, France. S. Deshayes, MD, CHU de Caen, Department of Internal Medicine, Université Caen Normandie, Medical School; S. Georgin-Lavialle, MD, PhD, Tenon Hospital, Department of Internal Medicine, University Pierre and Marie Curie-Paris 6; A. Hot, MD, PhD, Edouard Herriot Hospital, Department of Internal Medicine; C.A. Durel, MD, Edouard Herriot Hospital, Department of Internal Medicine; E. Hachulla, MD, PhD, Claude Huriez Hospital, Department of Internal Medicine, University of Lille; N. Rouanes, MD, CH de Périgueux, Department of Internal Medicine; S. Audia, MD, PhD, CHU de Dijon, Department of Internal Medicine and Clinical Immunology; T. Le Gallou, MD, CHU de Rennes, Department of Internal Medicine; P. Quartier, MD, PhD, Hôpital Necker, Department of Pediatric Immunology, Hematology and Rheumatology; G. Urbanski, MD, CHU d’Angers, Department of Internal Medicine and Vascular Diseases; L. Messer, MD, CH de Colmar, Department of Rheumatology; S. Klein, MD, CHU de Caen, Department of Internal Medicine, Université Caen Normandie, Medical School; H. de Boysson, MD, CHU de Caen, Department of Internal Medicine, Université Caen Normandie, Medical School; B. Bienvenu, MD, PhD, CHU de Caen, Department of Internal Medicine, Université Caen Normandie, Medical School; G. Grateau, MD, PhD, Tenon Hospital, Department of Internal Medicine, University Pierre and Marie Curie-Paris 6; A. Aouba, MD, PhD, CHU de Caen, Department of Internal Medicine, Université Caen Normandie, Medical School. Address correspondence to Dr. A. Aouba, Department of Internal Medicine and Clinical Immunology, CHU Côte de Nacre, Université Basse Normandie, Avenue de la Côte de Nacre, 14000 Caen, France. E-mail: aouba-a@chu-caen.fr. Accepted for publication November 15, 2017.
Stéphane Klein
From the Department of Internal Medicine, Université Caen Normandie, Medical School, CHU de Caen, Caen; Department of Internal Medicine, Tenon Hospital, University Pierre and Marie Curie-Paris 6; Department of Pediatric Immunology, Hematology and Rheumatology, Hôpital Necker, Paris; Department of Internal Medicine, Edouard Herriot Hospital, Lyon; Department of Internal Medicine, Claude Huriez Hospital, University of Lille, Lille; Department of Internal Medicine, CH de Périgueux, Périgueux; Department of Internal Medicine and Clinical Immunology, CHU de Dijon, Dijon; Department of Internal Medicine, CHU de Rennes, Rennes; Department of Internal Medicine and Vascular Diseases, CHU d’Angers, Angers; Department of Rheumatology, CH de Colmar, Colmar, France. S. Deshayes, MD, CHU de Caen, Department of Internal Medicine, Université Caen Normandie, Medical School; S. Georgin-Lavialle, MD, PhD, Tenon Hospital, Department of Internal Medicine, University Pierre and Marie Curie-Paris 6; A. Hot, MD, PhD, Edouard Herriot Hospital, Department of Internal Medicine; C.A. Durel, MD, Edouard Herriot Hospital, Department of Internal Medicine; E. Hachulla, MD, PhD, Claude Huriez Hospital, Department of Internal Medicine, University of Lille; N. Rouanes, MD, CH de Périgueux, Department of Internal Medicine; S. Audia, MD, PhD, CHU de Dijon, Department of Internal Medicine and Clinical Immunology; T. Le Gallou, MD, CHU de Rennes, Department of Internal Medicine; P. Quartier, MD, PhD, Hôpital Necker, Department of Pediatric Immunology, Hematology and Rheumatology; G. Urbanski, MD, CHU d’Angers, Department of Internal Medicine and Vascular Diseases; L. Messer, MD, CH de Colmar, Department of Rheumatology; S. Klein, MD, CHU de Caen, Department of Internal Medicine, Université Caen Normandie, Medical School; H. de Boysson, MD, CHU de Caen, Department of Internal Medicine, Université Caen Normandie, Medical School; B. Bienvenu, MD, PhD, CHU de Caen, Department of Internal Medicine, Université Caen Normandie, Medical School; G. Grateau, MD, PhD, Tenon Hospital, Department of Internal Medicine, University Pierre and Marie Curie-Paris 6; A. Aouba, MD, PhD, CHU de Caen, Department of Internal Medicine, Université Caen Normandie, Medical School. Address correspondence to Dr. A. Aouba, Department of Internal Medicine and Clinical Immunology, CHU Côte de Nacre, Université Basse Normandie, Avenue de la Côte de Nacre, 14000 Caen, France. E-mail: aouba-a@chu-caen.fr. Accepted for publication November 15, 2017.
Hubert de Boysson
From the Department of Internal Medicine, Université Caen Normandie, Medical School, CHU de Caen, Caen; Department of Internal Medicine, Tenon Hospital, University Pierre and Marie Curie-Paris 6; Department of Pediatric Immunology, Hematology and Rheumatology, Hôpital Necker, Paris; Department of Internal Medicine, Edouard Herriot Hospital, Lyon; Department of Internal Medicine, Claude Huriez Hospital, University of Lille, Lille; Department of Internal Medicine, CH de Périgueux, Périgueux; Department of Internal Medicine and Clinical Immunology, CHU de Dijon, Dijon; Department of Internal Medicine, CHU de Rennes, Rennes; Department of Internal Medicine and Vascular Diseases, CHU d’Angers, Angers; Department of Rheumatology, CH de Colmar, Colmar, France. S. Deshayes, MD, CHU de Caen, Department of Internal Medicine, Université Caen Normandie, Medical School; S. Georgin-Lavialle, MD, PhD, Tenon Hospital, Department of Internal Medicine, University Pierre and Marie Curie-Paris 6; A. Hot, MD, PhD, Edouard Herriot Hospital, Department of Internal Medicine; C.A. Durel, MD, Edouard Herriot Hospital, Department of Internal Medicine; E. Hachulla, MD, PhD, Claude Huriez Hospital, Department of Internal Medicine, University of Lille; N. Rouanes, MD, CH de Périgueux, Department of Internal Medicine; S. Audia, MD, PhD, CHU de Dijon, Department of Internal Medicine and Clinical Immunology; T. Le Gallou, MD, CHU de Rennes, Department of Internal Medicine; P. Quartier, MD, PhD, Hôpital Necker, Department of Pediatric Immunology, Hematology and Rheumatology; G. Urbanski, MD, CHU d’Angers, Department of Internal Medicine and Vascular Diseases; L. Messer, MD, CH de Colmar, Department of Rheumatology; S. Klein, MD, CHU de Caen, Department of Internal Medicine, Université Caen Normandie, Medical School; H. de Boysson, MD, CHU de Caen, Department of Internal Medicine, Université Caen Normandie, Medical School; B. Bienvenu, MD, PhD, CHU de Caen, Department of Internal Medicine, Université Caen Normandie, Medical School; G. Grateau, MD, PhD, Tenon Hospital, Department of Internal Medicine, University Pierre and Marie Curie-Paris 6; A. Aouba, MD, PhD, CHU de Caen, Department of Internal Medicine, Université Caen Normandie, Medical School. Address correspondence to Dr. A. Aouba, Department of Internal Medicine and Clinical Immunology, CHU Côte de Nacre, Université Basse Normandie, Avenue de la Côte de Nacre, 14000 Caen, France. E-mail: aouba-a@chu-caen.fr. Accepted for publication November 15, 2017.
Boris Bienvenu
From the Department of Internal Medicine, Université Caen Normandie, Medical School, CHU de Caen, Caen; Department of Internal Medicine, Tenon Hospital, University Pierre and Marie Curie-Paris 6; Department of Pediatric Immunology, Hematology and Rheumatology, Hôpital Necker, Paris; Department of Internal Medicine, Edouard Herriot Hospital, Lyon; Department of Internal Medicine, Claude Huriez Hospital, University of Lille, Lille; Department of Internal Medicine, CH de Périgueux, Périgueux; Department of Internal Medicine and Clinical Immunology, CHU de Dijon, Dijon; Department of Internal Medicine, CHU de Rennes, Rennes; Department of Internal Medicine and Vascular Diseases, CHU d’Angers, Angers; Department of Rheumatology, CH de Colmar, Colmar, France. S. Deshayes, MD, CHU de Caen, Department of Internal Medicine, Université Caen Normandie, Medical School; S. Georgin-Lavialle, MD, PhD, Tenon Hospital, Department of Internal Medicine, University Pierre and Marie Curie-Paris 6; A. Hot, MD, PhD, Edouard Herriot Hospital, Department of Internal Medicine; C.A. Durel, MD, Edouard Herriot Hospital, Department of Internal Medicine; E. Hachulla, MD, PhD, Claude Huriez Hospital, Department of Internal Medicine, University of Lille; N. Rouanes, MD, CH de Périgueux, Department of Internal Medicine; S. Audia, MD, PhD, CHU de Dijon, Department of Internal Medicine and Clinical Immunology; T. Le Gallou, MD, CHU de Rennes, Department of Internal Medicine; P. Quartier, MD, PhD, Hôpital Necker, Department of Pediatric Immunology, Hematology and Rheumatology; G. Urbanski, MD, CHU d’Angers, Department of Internal Medicine and Vascular Diseases; L. Messer, MD, CH de Colmar, Department of Rheumatology; S. Klein, MD, CHU de Caen, Department of Internal Medicine, Université Caen Normandie, Medical School; H. de Boysson, MD, CHU de Caen, Department of Internal Medicine, Université Caen Normandie, Medical School; B. Bienvenu, MD, PhD, CHU de Caen, Department of Internal Medicine, Université Caen Normandie, Medical School; G. Grateau, MD, PhD, Tenon Hospital, Department of Internal Medicine, University Pierre and Marie Curie-Paris 6; A. Aouba, MD, PhD, CHU de Caen, Department of Internal Medicine, Université Caen Normandie, Medical School. Address correspondence to Dr. A. Aouba, Department of Internal Medicine and Clinical Immunology, CHU Côte de Nacre, Université Basse Normandie, Avenue de la Côte de Nacre, 14000 Caen, France. E-mail: aouba-a@chu-caen.fr. Accepted for publication November 15, 2017.
Gilles Grateau
From the Department of Internal Medicine, Université Caen Normandie, Medical School, CHU de Caen, Caen; Department of Internal Medicine, Tenon Hospital, University Pierre and Marie Curie-Paris 6; Department of Pediatric Immunology, Hematology and Rheumatology, Hôpital Necker, Paris; Department of Internal Medicine, Edouard Herriot Hospital, Lyon; Department of Internal Medicine, Claude Huriez Hospital, University of Lille, Lille; Department of Internal Medicine, CH de Périgueux, Périgueux; Department of Internal Medicine and Clinical Immunology, CHU de Dijon, Dijon; Department of Internal Medicine, CHU de Rennes, Rennes; Department of Internal Medicine and Vascular Diseases, CHU d’Angers, Angers; Department of Rheumatology, CH de Colmar, Colmar, France. S. Deshayes, MD, CHU de Caen, Department of Internal Medicine, Université Caen Normandie, Medical School; S. Georgin-Lavialle, MD, PhD, Tenon Hospital, Department of Internal Medicine, University Pierre and Marie Curie-Paris 6; A. Hot, MD, PhD, Edouard Herriot Hospital, Department of Internal Medicine; C.A. Durel, MD, Edouard Herriot Hospital, Department of Internal Medicine; E. Hachulla, MD, PhD, Claude Huriez Hospital, Department of Internal Medicine, University of Lille; N. Rouanes, MD, CH de Périgueux, Department of Internal Medicine; S. Audia, MD, PhD, CHU de Dijon, Department of Internal Medicine and Clinical Immunology; T. Le Gallou, MD, CHU de Rennes, Department of Internal Medicine; P. Quartier, MD, PhD, Hôpital Necker, Department of Pediatric Immunology, Hematology and Rheumatology; G. Urbanski, MD, CHU d’Angers, Department of Internal Medicine and Vascular Diseases; L. Messer, MD, CH de Colmar, Department of Rheumatology; S. Klein, MD, CHU de Caen, Department of Internal Medicine, Université Caen Normandie, Medical School; H. de Boysson, MD, CHU de Caen, Department of Internal Medicine, Université Caen Normandie, Medical School; B. Bienvenu, MD, PhD, CHU de Caen, Department of Internal Medicine, Université Caen Normandie, Medical School; G. Grateau, MD, PhD, Tenon Hospital, Department of Internal Medicine, University Pierre and Marie Curie-Paris 6; A. Aouba, MD, PhD, CHU de Caen, Department of Internal Medicine, Université Caen Normandie, Medical School. Address correspondence to Dr. A. Aouba, Department of Internal Medicine and Clinical Immunology, CHU Côte de Nacre, Université Basse Normandie, Avenue de la Côte de Nacre, 14000 Caen, France. E-mail: aouba-a@chu-caen.fr. Accepted for publication November 15, 2017.
Achille Aouba
From the Department of Internal Medicine, Université Caen Normandie, Medical School, CHU de Caen, Caen; Department of Internal Medicine, Tenon Hospital, University Pierre and Marie Curie-Paris 6; Department of Pediatric Immunology, Hematology and Rheumatology, Hôpital Necker, Paris; Department of Internal Medicine, Edouard Herriot Hospital, Lyon; Department of Internal Medicine, Claude Huriez Hospital, University of Lille, Lille; Department of Internal Medicine, CH de Périgueux, Périgueux; Department of Internal Medicine and Clinical Immunology, CHU de Dijon, Dijon; Department of Internal Medicine, CHU de Rennes, Rennes; Department of Internal Medicine and Vascular Diseases, CHU d’Angers, Angers; Department of Rheumatology, CH de Colmar, Colmar, France. S. Deshayes, MD, CHU de Caen, Department of Internal Medicine, Université Caen Normandie, Medical School; S. Georgin-Lavialle, MD, PhD, Tenon Hospital, Department of Internal Medicine, University Pierre and Marie Curie-Paris 6; A. Hot, MD, PhD, Edouard Herriot Hospital, Department of Internal Medicine; C.A. Durel, MD, Edouard Herriot Hospital, Department of Internal Medicine; E. Hachulla, MD, PhD, Claude Huriez Hospital, Department of Internal Medicine, University of Lille; N. Rouanes, MD, CH de Périgueux, Department of Internal Medicine; S. Audia, MD, PhD, CHU de Dijon, Department of Internal Medicine and Clinical Immunology; T. Le Gallou, MD, CHU de Rennes, Department of Internal Medicine; P. Quartier, MD, PhD, Hôpital Necker, Department of Pediatric Immunology, Hematology and Rheumatology; G. Urbanski, MD, CHU d’Angers, Department of Internal Medicine and Vascular Diseases; L. Messer, MD, CH de Colmar, Department of Rheumatology; S. Klein, MD, CHU de Caen, Department of Internal Medicine, Université Caen Normandie, Medical School; H. de Boysson, MD, CHU de Caen, Department of Internal Medicine, Université Caen Normandie, Medical School; B. Bienvenu, MD, PhD, CHU de Caen, Department of Internal Medicine, Université Caen Normandie, Medical School; G. Grateau, MD, PhD, Tenon Hospital, Department of Internal Medicine, University Pierre and Marie Curie-Paris 6; A. Aouba, MD, PhD, CHU de Caen, Department of Internal Medicine, Université Caen Normandie, Medical School. Address correspondence to Dr. A. Aouba, Department of Internal Medicine and Clinical Immunology, CHU Côte de Nacre, Université Basse Normandie, Avenue de la Côte de Nacre, 14000 Caen, France. E-mail: aouba-a@chu-caen.fr. Accepted for publication November 15, 2017.
Abstract
Objective To report efficacy and tolerance of interleukin 1 blockade in adult patients with mevalonate kinase deficiency (MKD).
Methods We retrospectively collected data on 13 patients with MKD who had received anakinra (n = 10) and canakinumab (n = 7).
Results Anakinra resulted in complete or partial remission in 3/10 and 5/10 patients, respectively, and no efficacy in 2/10, but a switch to canakinumab led to partial remission. Canakinumab resulted in complete or partial remission in 3/7 and 4/7 patients, respectively.
Conclusion These data support frequent partial responses, showing a better response with canakinumab. The genotype and therapeutic outcomes correlation should help in the personalization of treatment.
In this issue
The Journal of Rheumatology
Vol. 51, Issue 3
1 Mar 2024
Efficacy of Continuous Interleukin 1 Blockade in Mevalonate Kinase Deficiency: A Multicenter Retrospective Study in 13 Adult Patients and Literature Review
Samuel Deshayes, Sophie Georgin-Lavialle, Arnaud Hot, Cécile-Audrey Durel, Eric Hachulla, Nicolas Rouanes, Sylvain Audia, Thomas Le Gallou, Pierre Quartier, Geoffrey Urbanski, Laurent Messer, Stéphane Klein, Hubert de Boysson, Boris Bienvenu, Gilles Grateau, Achille Aouba
The Journal of Rheumatology Jan 2018, jrheum.170684; DOI: 10.3899/jrheum.170684
Efficacy of Continuous Interleukin 1 Blockade in Mevalonate Kinase Deficiency: A Multicenter Retrospective Study in 13 Adult Patients and Literature Review
Samuel Deshayes, Sophie Georgin-Lavialle, Arnaud Hot, Cécile-Audrey Durel, Eric Hachulla, Nicolas Rouanes, Sylvain Audia, Thomas Le Gallou, Pierre Quartier, Geoffrey Urbanski, Laurent Messer, Stéphane Klein, Hubert de Boysson, Boris Bienvenu, Gilles Grateau, Achille Aouba
The Journal of Rheumatology Jan 2018, jrheum.170684; DOI: 10.3899/jrheum.170684