Research ArticleArticle
Synoviocytes-derived Interleukin 35 Potentiates B Cell Response in Patients with Osteoarthritis and Rheumatoid Arthritis
Ngar-Woon Kam, Dehua Liu, Zhe Cai, Wah-Yan Mak, Chun-Kwok Wong, Kwok-Hing Chiu, Kam-Yiu Wong, Wai-Leuk Tsang and Lai-Shan Tam
The Journal of Rheumatology December 2017, jrheum.161363; DOI: https://doi.org/10.3899/jrheum.161363
Ngar-Woon Kam
From the Department of Medicine and Therapeutics, and Department of Chemical Pathology, and Institute of Chinese Medicine and State Key Laboratory of Phytochemistry and Plant Resources in West China, The Chinese University of Hong Kong; Department of Orthopaedics and Traumatology, Prince of Wales Hospital; Department of Orthopaedics and Traumatology, Princess Margaret Hospital; Department of Orthopaedics and Traumatology, Pamela Youde Nethersole Eastern Hospital, Hong Kong, China. Supported by The Hong Kong Society of Rheumatology project fund. N.W. Kam, PhD, Department of Medicine and Therapeutics, The Chinese University of Hong Kong; D. Liu, MPhil, Institute of Chinese Medicine and State Key Laboratory of Phytochemistry and Plant Resources in West China, The Chinese University of Hong Kong; Z. Cai, PhD, Department of Chemical Pathology, The Chinese University of Hong Kong; W.Y. Mak, BSc, Department of Medicine and Therapeutics, The Chinese University of Hong Kong; C.K. Wong, PhD, Institute of Chinese Medicine and State Key Laboratory of Phytochemistry and Plant Resources in West China, The Chinese University of Hong Kong, and Department of Chemical Pathology, The Chinese University of Hong Kong; K.H. Chiu, FRCS, Department of Orthopaedics and Traumatology, Prince of Wales Hospital; K.Y. Wong, FRCS, Department of Orthopaedics and Traumatology, Princess Margaret Hospital; W.L. Tsang, FRCS, Department of Orthopaedics and Traumatology, Pamela Youde Nethersole Eastern Hospital; L.S. Tam, MD, Department of Medicine and Therapeutics, The Chinese University of Hong Kong. Address correspondence to Dr. L.S. Tam, Department of Medicine and Therapeutics, Prince of Wales Hospital, The Chinese University of Hong Kong, Shatin, Hong Kong, China. E-mail: lstam@cuhk.edu.hk. Accepted for publication September 29, 2017.
Dehua Liu
From the Department of Medicine and Therapeutics, and Department of Chemical Pathology, and Institute of Chinese Medicine and State Key Laboratory of Phytochemistry and Plant Resources in West China, The Chinese University of Hong Kong; Department of Orthopaedics and Traumatology, Prince of Wales Hospital; Department of Orthopaedics and Traumatology, Princess Margaret Hospital; Department of Orthopaedics and Traumatology, Pamela Youde Nethersole Eastern Hospital, Hong Kong, China. Supported by The Hong Kong Society of Rheumatology project fund. N.W. Kam, PhD, Department of Medicine and Therapeutics, The Chinese University of Hong Kong; D. Liu, MPhil, Institute of Chinese Medicine and State Key Laboratory of Phytochemistry and Plant Resources in West China, The Chinese University of Hong Kong; Z. Cai, PhD, Department of Chemical Pathology, The Chinese University of Hong Kong; W.Y. Mak, BSc, Department of Medicine and Therapeutics, The Chinese University of Hong Kong; C.K. Wong, PhD, Institute of Chinese Medicine and State Key Laboratory of Phytochemistry and Plant Resources in West China, The Chinese University of Hong Kong, and Department of Chemical Pathology, The Chinese University of Hong Kong; K.H. Chiu, FRCS, Department of Orthopaedics and Traumatology, Prince of Wales Hospital; K.Y. Wong, FRCS, Department of Orthopaedics and Traumatology, Princess Margaret Hospital; W.L. Tsang, FRCS, Department of Orthopaedics and Traumatology, Pamela Youde Nethersole Eastern Hospital; L.S. Tam, MD, Department of Medicine and Therapeutics, The Chinese University of Hong Kong. Address correspondence to Dr. L.S. Tam, Department of Medicine and Therapeutics, Prince of Wales Hospital, The Chinese University of Hong Kong, Shatin, Hong Kong, China. E-mail: lstam@cuhk.edu.hk. Accepted for publication September 29, 2017.
Zhe Cai
From the Department of Medicine and Therapeutics, and Department of Chemical Pathology, and Institute of Chinese Medicine and State Key Laboratory of Phytochemistry and Plant Resources in West China, The Chinese University of Hong Kong; Department of Orthopaedics and Traumatology, Prince of Wales Hospital; Department of Orthopaedics and Traumatology, Princess Margaret Hospital; Department of Orthopaedics and Traumatology, Pamela Youde Nethersole Eastern Hospital, Hong Kong, China. Supported by The Hong Kong Society of Rheumatology project fund. N.W. Kam, PhD, Department of Medicine and Therapeutics, The Chinese University of Hong Kong; D. Liu, MPhil, Institute of Chinese Medicine and State Key Laboratory of Phytochemistry and Plant Resources in West China, The Chinese University of Hong Kong; Z. Cai, PhD, Department of Chemical Pathology, The Chinese University of Hong Kong; W.Y. Mak, BSc, Department of Medicine and Therapeutics, The Chinese University of Hong Kong; C.K. Wong, PhD, Institute of Chinese Medicine and State Key Laboratory of Phytochemistry and Plant Resources in West China, The Chinese University of Hong Kong, and Department of Chemical Pathology, The Chinese University of Hong Kong; K.H. Chiu, FRCS, Department of Orthopaedics and Traumatology, Prince of Wales Hospital; K.Y. Wong, FRCS, Department of Orthopaedics and Traumatology, Princess Margaret Hospital; W.L. Tsang, FRCS, Department of Orthopaedics and Traumatology, Pamela Youde Nethersole Eastern Hospital; L.S. Tam, MD, Department of Medicine and Therapeutics, The Chinese University of Hong Kong. Address correspondence to Dr. L.S. Tam, Department of Medicine and Therapeutics, Prince of Wales Hospital, The Chinese University of Hong Kong, Shatin, Hong Kong, China. E-mail: lstam@cuhk.edu.hk. Accepted for publication September 29, 2017.
Wah-Yan Mak
From the Department of Medicine and Therapeutics, and Department of Chemical Pathology, and Institute of Chinese Medicine and State Key Laboratory of Phytochemistry and Plant Resources in West China, The Chinese University of Hong Kong; Department of Orthopaedics and Traumatology, Prince of Wales Hospital; Department of Orthopaedics and Traumatology, Princess Margaret Hospital; Department of Orthopaedics and Traumatology, Pamela Youde Nethersole Eastern Hospital, Hong Kong, China. Supported by The Hong Kong Society of Rheumatology project fund. N.W. Kam, PhD, Department of Medicine and Therapeutics, The Chinese University of Hong Kong; D. Liu, MPhil, Institute of Chinese Medicine and State Key Laboratory of Phytochemistry and Plant Resources in West China, The Chinese University of Hong Kong; Z. Cai, PhD, Department of Chemical Pathology, The Chinese University of Hong Kong; W.Y. Mak, BSc, Department of Medicine and Therapeutics, The Chinese University of Hong Kong; C.K. Wong, PhD, Institute of Chinese Medicine and State Key Laboratory of Phytochemistry and Plant Resources in West China, The Chinese University of Hong Kong, and Department of Chemical Pathology, The Chinese University of Hong Kong; K.H. Chiu, FRCS, Department of Orthopaedics and Traumatology, Prince of Wales Hospital; K.Y. Wong, FRCS, Department of Orthopaedics and Traumatology, Princess Margaret Hospital; W.L. Tsang, FRCS, Department of Orthopaedics and Traumatology, Pamela Youde Nethersole Eastern Hospital; L.S. Tam, MD, Department of Medicine and Therapeutics, The Chinese University of Hong Kong. Address correspondence to Dr. L.S. Tam, Department of Medicine and Therapeutics, Prince of Wales Hospital, The Chinese University of Hong Kong, Shatin, Hong Kong, China. E-mail: lstam@cuhk.edu.hk. Accepted for publication September 29, 2017.
Chun-Kwok Wong
From the Department of Medicine and Therapeutics, and Department of Chemical Pathology, and Institute of Chinese Medicine and State Key Laboratory of Phytochemistry and Plant Resources in West China, The Chinese University of Hong Kong; Department of Orthopaedics and Traumatology, Prince of Wales Hospital; Department of Orthopaedics and Traumatology, Princess Margaret Hospital; Department of Orthopaedics and Traumatology, Pamela Youde Nethersole Eastern Hospital, Hong Kong, China. Supported by The Hong Kong Society of Rheumatology project fund. N.W. Kam, PhD, Department of Medicine and Therapeutics, The Chinese University of Hong Kong; D. Liu, MPhil, Institute of Chinese Medicine and State Key Laboratory of Phytochemistry and Plant Resources in West China, The Chinese University of Hong Kong; Z. Cai, PhD, Department of Chemical Pathology, The Chinese University of Hong Kong; W.Y. Mak, BSc, Department of Medicine and Therapeutics, The Chinese University of Hong Kong; C.K. Wong, PhD, Institute of Chinese Medicine and State Key Laboratory of Phytochemistry and Plant Resources in West China, The Chinese University of Hong Kong, and Department of Chemical Pathology, The Chinese University of Hong Kong; K.H. Chiu, FRCS, Department of Orthopaedics and Traumatology, Prince of Wales Hospital; K.Y. Wong, FRCS, Department of Orthopaedics and Traumatology, Princess Margaret Hospital; W.L. Tsang, FRCS, Department of Orthopaedics and Traumatology, Pamela Youde Nethersole Eastern Hospital; L.S. Tam, MD, Department of Medicine and Therapeutics, The Chinese University of Hong Kong. Address correspondence to Dr. L.S. Tam, Department of Medicine and Therapeutics, Prince of Wales Hospital, The Chinese University of Hong Kong, Shatin, Hong Kong, China. E-mail: lstam@cuhk.edu.hk. Accepted for publication September 29, 2017.
Kwok-Hing Chiu
From the Department of Medicine and Therapeutics, and Department of Chemical Pathology, and Institute of Chinese Medicine and State Key Laboratory of Phytochemistry and Plant Resources in West China, The Chinese University of Hong Kong; Department of Orthopaedics and Traumatology, Prince of Wales Hospital; Department of Orthopaedics and Traumatology, Princess Margaret Hospital; Department of Orthopaedics and Traumatology, Pamela Youde Nethersole Eastern Hospital, Hong Kong, China. Supported by The Hong Kong Society of Rheumatology project fund. N.W. Kam, PhD, Department of Medicine and Therapeutics, The Chinese University of Hong Kong; D. Liu, MPhil, Institute of Chinese Medicine and State Key Laboratory of Phytochemistry and Plant Resources in West China, The Chinese University of Hong Kong; Z. Cai, PhD, Department of Chemical Pathology, The Chinese University of Hong Kong; W.Y. Mak, BSc, Department of Medicine and Therapeutics, The Chinese University of Hong Kong; C.K. Wong, PhD, Institute of Chinese Medicine and State Key Laboratory of Phytochemistry and Plant Resources in West China, The Chinese University of Hong Kong, and Department of Chemical Pathology, The Chinese University of Hong Kong; K.H. Chiu, FRCS, Department of Orthopaedics and Traumatology, Prince of Wales Hospital; K.Y. Wong, FRCS, Department of Orthopaedics and Traumatology, Princess Margaret Hospital; W.L. Tsang, FRCS, Department of Orthopaedics and Traumatology, Pamela Youde Nethersole Eastern Hospital; L.S. Tam, MD, Department of Medicine and Therapeutics, The Chinese University of Hong Kong. Address correspondence to Dr. L.S. Tam, Department of Medicine and Therapeutics, Prince of Wales Hospital, The Chinese University of Hong Kong, Shatin, Hong Kong, China. E-mail: lstam@cuhk.edu.hk. Accepted for publication September 29, 2017.
Kam-Yiu Wong
From the Department of Medicine and Therapeutics, and Department of Chemical Pathology, and Institute of Chinese Medicine and State Key Laboratory of Phytochemistry and Plant Resources in West China, The Chinese University of Hong Kong; Department of Orthopaedics and Traumatology, Prince of Wales Hospital; Department of Orthopaedics and Traumatology, Princess Margaret Hospital; Department of Orthopaedics and Traumatology, Pamela Youde Nethersole Eastern Hospital, Hong Kong, China. Supported by The Hong Kong Society of Rheumatology project fund. N.W. Kam, PhD, Department of Medicine and Therapeutics, The Chinese University of Hong Kong; D. Liu, MPhil, Institute of Chinese Medicine and State Key Laboratory of Phytochemistry and Plant Resources in West China, The Chinese University of Hong Kong; Z. Cai, PhD, Department of Chemical Pathology, The Chinese University of Hong Kong; W.Y. Mak, BSc, Department of Medicine and Therapeutics, The Chinese University of Hong Kong; C.K. Wong, PhD, Institute of Chinese Medicine and State Key Laboratory of Phytochemistry and Plant Resources in West China, The Chinese University of Hong Kong, and Department of Chemical Pathology, The Chinese University of Hong Kong; K.H. Chiu, FRCS, Department of Orthopaedics and Traumatology, Prince of Wales Hospital; K.Y. Wong, FRCS, Department of Orthopaedics and Traumatology, Princess Margaret Hospital; W.L. Tsang, FRCS, Department of Orthopaedics and Traumatology, Pamela Youde Nethersole Eastern Hospital; L.S. Tam, MD, Department of Medicine and Therapeutics, The Chinese University of Hong Kong. Address correspondence to Dr. L.S. Tam, Department of Medicine and Therapeutics, Prince of Wales Hospital, The Chinese University of Hong Kong, Shatin, Hong Kong, China. E-mail: lstam@cuhk.edu.hk. Accepted for publication September 29, 2017.
Wai-Leuk Tsang
From the Department of Medicine and Therapeutics, and Department of Chemical Pathology, and Institute of Chinese Medicine and State Key Laboratory of Phytochemistry and Plant Resources in West China, The Chinese University of Hong Kong; Department of Orthopaedics and Traumatology, Prince of Wales Hospital; Department of Orthopaedics and Traumatology, Princess Margaret Hospital; Department of Orthopaedics and Traumatology, Pamela Youde Nethersole Eastern Hospital, Hong Kong, China. Supported by The Hong Kong Society of Rheumatology project fund. N.W. Kam, PhD, Department of Medicine and Therapeutics, The Chinese University of Hong Kong; D. Liu, MPhil, Institute of Chinese Medicine and State Key Laboratory of Phytochemistry and Plant Resources in West China, The Chinese University of Hong Kong; Z. Cai, PhD, Department of Chemical Pathology, The Chinese University of Hong Kong; W.Y. Mak, BSc, Department of Medicine and Therapeutics, The Chinese University of Hong Kong; C.K. Wong, PhD, Institute of Chinese Medicine and State Key Laboratory of Phytochemistry and Plant Resources in West China, The Chinese University of Hong Kong, and Department of Chemical Pathology, The Chinese University of Hong Kong; K.H. Chiu, FRCS, Department of Orthopaedics and Traumatology, Prince of Wales Hospital; K.Y. Wong, FRCS, Department of Orthopaedics and Traumatology, Princess Margaret Hospital; W.L. Tsang, FRCS, Department of Orthopaedics and Traumatology, Pamela Youde Nethersole Eastern Hospital; L.S. Tam, MD, Department of Medicine and Therapeutics, The Chinese University of Hong Kong. Address correspondence to Dr. L.S. Tam, Department of Medicine and Therapeutics, Prince of Wales Hospital, The Chinese University of Hong Kong, Shatin, Hong Kong, China. E-mail: lstam@cuhk.edu.hk. Accepted for publication September 29, 2017.
Lai-Shan Tam
From the Department of Medicine and Therapeutics, and Department of Chemical Pathology, and Institute of Chinese Medicine and State Key Laboratory of Phytochemistry and Plant Resources in West China, The Chinese University of Hong Kong; Department of Orthopaedics and Traumatology, Prince of Wales Hospital; Department of Orthopaedics and Traumatology, Princess Margaret Hospital; Department of Orthopaedics and Traumatology, Pamela Youde Nethersole Eastern Hospital, Hong Kong, China. Supported by The Hong Kong Society of Rheumatology project fund. N.W. Kam, PhD, Department of Medicine and Therapeutics, The Chinese University of Hong Kong; D. Liu, MPhil, Institute of Chinese Medicine and State Key Laboratory of Phytochemistry and Plant Resources in West China, The Chinese University of Hong Kong; Z. Cai, PhD, Department of Chemical Pathology, The Chinese University of Hong Kong; W.Y. Mak, BSc, Department of Medicine and Therapeutics, The Chinese University of Hong Kong; C.K. Wong, PhD, Institute of Chinese Medicine and State Key Laboratory of Phytochemistry and Plant Resources in West China, The Chinese University of Hong Kong, and Department of Chemical Pathology, The Chinese University of Hong Kong; K.H. Chiu, FRCS, Department of Orthopaedics and Traumatology, Prince of Wales Hospital; K.Y. Wong, FRCS, Department of Orthopaedics and Traumatology, Princess Margaret Hospital; W.L. Tsang, FRCS, Department of Orthopaedics and Traumatology, Pamela Youde Nethersole Eastern Hospital; L.S. Tam, MD, Department of Medicine and Therapeutics, The Chinese University of Hong Kong. Address correspondence to Dr. L.S. Tam, Department of Medicine and Therapeutics, Prince of Wales Hospital, The Chinese University of Hong Kong, Shatin, Hong Kong, China. E-mail: lstam@cuhk.edu.hk. Accepted for publication September 29, 2017.
Data supplements
Data Supplement
Files in this Data Supplement:
In this issue
The Journal of Rheumatology
Vol. 51, Issue 3
1 Mar 2024
Synoviocytes-derived Interleukin 35 Potentiates B Cell Response in Patients with Osteoarthritis and Rheumatoid Arthritis
Ngar-Woon Kam, Dehua Liu, Zhe Cai, Wah-Yan Mak, Chun-Kwok Wong, Kwok-Hing Chiu, Kam-Yiu Wong, Wai-Leuk Tsang, Lai-Shan Tam
The Journal of Rheumatology Dec 2017, jrheum.161363; DOI: 10.3899/jrheum.161363
Synoviocytes-derived Interleukin 35 Potentiates B Cell Response in Patients with Osteoarthritis and Rheumatoid Arthritis
Ngar-Woon Kam, Dehua Liu, Zhe Cai, Wah-Yan Mak, Chun-Kwok Wong, Kwok-Hing Chiu, Kam-Yiu Wong, Wai-Leuk Tsang, Lai-Shan Tam
The Journal of Rheumatology Dec 2017, jrheum.161363; DOI: 10.3899/jrheum.161363