Research ArticleArticle
Rebound in Measures of Disease Activity and Symptoms in Corrona Registry Patients with Psoriatic Arthritis Who Discontinue Tumor Necrosis Factor Inhibitor Therapy after Achieving Low Disease Activity
Leslie R. Harrold, Bradley S. Stolshek, Sabrina Rebello, David H. Collier, Alex Mutebi, Sally W. Wade, Wendi Malley, Jeffrey D. Greenberg and Carol J. Etzel
The Journal of Rheumatology October 2017, jrheum.161567; DOI: https://doi.org/10.3899/jrheum.161567
Leslie R. Harrold
From Corrona LLC, Southborough; Department of Medicine, University of Massachusetts Medical School, Worcester, Massachusetts; Amgen Inc., Thousand Oaks, California; Wade Outcomes Research and Consulting, Salt Lake City, Utah; New York University School of Medicine, New York, New York; Department of Epidemiology, University of Texas, MD Anderson Cancer Center, Houston, Texas, USA. Sponsored by Corrona LLC. Corrona LLC has been supported through contracted subscriptions in the last 2 years by AbbVie, Amgen, BMS, Crescendo, Eli Lilly and Company, Genentech, GSK, Horizon Pharma USA, Janssen, Momenta Pharmaceuticals, Novartis, Pfizer, Roche, and UCB. LRH is an employee and shareholder of Corrona LLC, and has a research grant to the University of Massachusetts Medical School from Pfizer. BSS, DHC, and AM are employees and shareholders of Amgen Inc. SR and WM are employees of Corrona LLC. SWW is a consultant of Amgen Inc. JDG is an employee and shareholder of Corrona LLC, and a consultant of Eli Lilly, Genentech, Janssen, Novartis, and Pfizer. CJE is an employee of Corrona LLC and an advisory board member for Merck. L.R. Harrold, MD, MPH, Corrona LLC, and Department of Medicine, University of Massachusetts Medical School; B.S. Stolshek, PharmD, Amgen Inc.; S. Rebello, MPH, Corrona LLC; D.H. Collier, MD, Amgen Inc.; A. Mutebi, PhD, Amgen Inc.; S.W. Wade, MPH, Wade Outcomes Research and Consulting; W. Malley, MS, Corrona LLC, and New York University School of Medicine; J.D. Greenberg, MD, MPH, Corrona LLC; C.J. Etzel, PhD, Corrona LLC, and Department of Epidemiology, University of Texas, MD Anderson Cancer Center. Address correspondence to Dr. L.R. Harrold, University of Massachusetts Medical School, Medicine, 55 Lake Ave. North, Worcester, Massachusetts 01655, USA. E-mail: Leslie.Harrold@umassmed.edu. Accepted for publication July 19, 2017.
Bradley S. Stolshek
From Corrona LLC, Southborough; Department of Medicine, University of Massachusetts Medical School, Worcester, Massachusetts; Amgen Inc., Thousand Oaks, California; Wade Outcomes Research and Consulting, Salt Lake City, Utah; New York University School of Medicine, New York, New York; Department of Epidemiology, University of Texas, MD Anderson Cancer Center, Houston, Texas, USA. Sponsored by Corrona LLC. Corrona LLC has been supported through contracted subscriptions in the last 2 years by AbbVie, Amgen, BMS, Crescendo, Eli Lilly and Company, Genentech, GSK, Horizon Pharma USA, Janssen, Momenta Pharmaceuticals, Novartis, Pfizer, Roche, and UCB. LRH is an employee and shareholder of Corrona LLC, and has a research grant to the University of Massachusetts Medical School from Pfizer. BSS, DHC, and AM are employees and shareholders of Amgen Inc. SR and WM are employees of Corrona LLC. SWW is a consultant of Amgen Inc. JDG is an employee and shareholder of Corrona LLC, and a consultant of Eli Lilly, Genentech, Janssen, Novartis, and Pfizer. CJE is an employee of Corrona LLC and an advisory board member for Merck. L.R. Harrold, MD, MPH, Corrona LLC, and Department of Medicine, University of Massachusetts Medical School; B.S. Stolshek, PharmD, Amgen Inc.; S. Rebello, MPH, Corrona LLC; D.H. Collier, MD, Amgen Inc.; A. Mutebi, PhD, Amgen Inc.; S.W. Wade, MPH, Wade Outcomes Research and Consulting; W. Malley, MS, Corrona LLC, and New York University School of Medicine; J.D. Greenberg, MD, MPH, Corrona LLC; C.J. Etzel, PhD, Corrona LLC, and Department of Epidemiology, University of Texas, MD Anderson Cancer Center. Address correspondence to Dr. L.R. Harrold, University of Massachusetts Medical School, Medicine, 55 Lake Ave. North, Worcester, Massachusetts 01655, USA. E-mail: Leslie.Harrold@umassmed.edu. Accepted for publication July 19, 2017.
Sabrina Rebello
From Corrona LLC, Southborough; Department of Medicine, University of Massachusetts Medical School, Worcester, Massachusetts; Amgen Inc., Thousand Oaks, California; Wade Outcomes Research and Consulting, Salt Lake City, Utah; New York University School of Medicine, New York, New York; Department of Epidemiology, University of Texas, MD Anderson Cancer Center, Houston, Texas, USA. Sponsored by Corrona LLC. Corrona LLC has been supported through contracted subscriptions in the last 2 years by AbbVie, Amgen, BMS, Crescendo, Eli Lilly and Company, Genentech, GSK, Horizon Pharma USA, Janssen, Momenta Pharmaceuticals, Novartis, Pfizer, Roche, and UCB. LRH is an employee and shareholder of Corrona LLC, and has a research grant to the University of Massachusetts Medical School from Pfizer. BSS, DHC, and AM are employees and shareholders of Amgen Inc. SR and WM are employees of Corrona LLC. SWW is a consultant of Amgen Inc. JDG is an employee and shareholder of Corrona LLC, and a consultant of Eli Lilly, Genentech, Janssen, Novartis, and Pfizer. CJE is an employee of Corrona LLC and an advisory board member for Merck. L.R. Harrold, MD, MPH, Corrona LLC, and Department of Medicine, University of Massachusetts Medical School; B.S. Stolshek, PharmD, Amgen Inc.; S. Rebello, MPH, Corrona LLC; D.H. Collier, MD, Amgen Inc.; A. Mutebi, PhD, Amgen Inc.; S.W. Wade, MPH, Wade Outcomes Research and Consulting; W. Malley, MS, Corrona LLC, and New York University School of Medicine; J.D. Greenberg, MD, MPH, Corrona LLC; C.J. Etzel, PhD, Corrona LLC, and Department of Epidemiology, University of Texas, MD Anderson Cancer Center. Address correspondence to Dr. L.R. Harrold, University of Massachusetts Medical School, Medicine, 55 Lake Ave. North, Worcester, Massachusetts 01655, USA. E-mail: Leslie.Harrold@umassmed.edu. Accepted for publication July 19, 2017.
David H. Collier
From Corrona LLC, Southborough; Department of Medicine, University of Massachusetts Medical School, Worcester, Massachusetts; Amgen Inc., Thousand Oaks, California; Wade Outcomes Research and Consulting, Salt Lake City, Utah; New York University School of Medicine, New York, New York; Department of Epidemiology, University of Texas, MD Anderson Cancer Center, Houston, Texas, USA. Sponsored by Corrona LLC. Corrona LLC has been supported through contracted subscriptions in the last 2 years by AbbVie, Amgen, BMS, Crescendo, Eli Lilly and Company, Genentech, GSK, Horizon Pharma USA, Janssen, Momenta Pharmaceuticals, Novartis, Pfizer, Roche, and UCB. LRH is an employee and shareholder of Corrona LLC, and has a research grant to the University of Massachusetts Medical School from Pfizer. BSS, DHC, and AM are employees and shareholders of Amgen Inc. SR and WM are employees of Corrona LLC. SWW is a consultant of Amgen Inc. JDG is an employee and shareholder of Corrona LLC, and a consultant of Eli Lilly, Genentech, Janssen, Novartis, and Pfizer. CJE is an employee of Corrona LLC and an advisory board member for Merck. L.R. Harrold, MD, MPH, Corrona LLC, and Department of Medicine, University of Massachusetts Medical School; B.S. Stolshek, PharmD, Amgen Inc.; S. Rebello, MPH, Corrona LLC; D.H. Collier, MD, Amgen Inc.; A. Mutebi, PhD, Amgen Inc.; S.W. Wade, MPH, Wade Outcomes Research and Consulting; W. Malley, MS, Corrona LLC, and New York University School of Medicine; J.D. Greenberg, MD, MPH, Corrona LLC; C.J. Etzel, PhD, Corrona LLC, and Department of Epidemiology, University of Texas, MD Anderson Cancer Center. Address correspondence to Dr. L.R. Harrold, University of Massachusetts Medical School, Medicine, 55 Lake Ave. North, Worcester, Massachusetts 01655, USA. E-mail: Leslie.Harrold@umassmed.edu. Accepted for publication July 19, 2017.
Alex Mutebi
From Corrona LLC, Southborough; Department of Medicine, University of Massachusetts Medical School, Worcester, Massachusetts; Amgen Inc., Thousand Oaks, California; Wade Outcomes Research and Consulting, Salt Lake City, Utah; New York University School of Medicine, New York, New York; Department of Epidemiology, University of Texas, MD Anderson Cancer Center, Houston, Texas, USA. Sponsored by Corrona LLC. Corrona LLC has been supported through contracted subscriptions in the last 2 years by AbbVie, Amgen, BMS, Crescendo, Eli Lilly and Company, Genentech, GSK, Horizon Pharma USA, Janssen, Momenta Pharmaceuticals, Novartis, Pfizer, Roche, and UCB. LRH is an employee and shareholder of Corrona LLC, and has a research grant to the University of Massachusetts Medical School from Pfizer. BSS, DHC, and AM are employees and shareholders of Amgen Inc. SR and WM are employees of Corrona LLC. SWW is a consultant of Amgen Inc. JDG is an employee and shareholder of Corrona LLC, and a consultant of Eli Lilly, Genentech, Janssen, Novartis, and Pfizer. CJE is an employee of Corrona LLC and an advisory board member for Merck. L.R. Harrold, MD, MPH, Corrona LLC, and Department of Medicine, University of Massachusetts Medical School; B.S. Stolshek, PharmD, Amgen Inc.; S. Rebello, MPH, Corrona LLC; D.H. Collier, MD, Amgen Inc.; A. Mutebi, PhD, Amgen Inc.; S.W. Wade, MPH, Wade Outcomes Research and Consulting; W. Malley, MS, Corrona LLC, and New York University School of Medicine; J.D. Greenberg, MD, MPH, Corrona LLC; C.J. Etzel, PhD, Corrona LLC, and Department of Epidemiology, University of Texas, MD Anderson Cancer Center. Address correspondence to Dr. L.R. Harrold, University of Massachusetts Medical School, Medicine, 55 Lake Ave. North, Worcester, Massachusetts 01655, USA. E-mail: Leslie.Harrold@umassmed.edu. Accepted for publication July 19, 2017.
Sally W. Wade
From Corrona LLC, Southborough; Department of Medicine, University of Massachusetts Medical School, Worcester, Massachusetts; Amgen Inc., Thousand Oaks, California; Wade Outcomes Research and Consulting, Salt Lake City, Utah; New York University School of Medicine, New York, New York; Department of Epidemiology, University of Texas, MD Anderson Cancer Center, Houston, Texas, USA. Sponsored by Corrona LLC. Corrona LLC has been supported through contracted subscriptions in the last 2 years by AbbVie, Amgen, BMS, Crescendo, Eli Lilly and Company, Genentech, GSK, Horizon Pharma USA, Janssen, Momenta Pharmaceuticals, Novartis, Pfizer, Roche, and UCB. LRH is an employee and shareholder of Corrona LLC, and has a research grant to the University of Massachusetts Medical School from Pfizer. BSS, DHC, and AM are employees and shareholders of Amgen Inc. SR and WM are employees of Corrona LLC. SWW is a consultant of Amgen Inc. JDG is an employee and shareholder of Corrona LLC, and a consultant of Eli Lilly, Genentech, Janssen, Novartis, and Pfizer. CJE is an employee of Corrona LLC and an advisory board member for Merck. L.R. Harrold, MD, MPH, Corrona LLC, and Department of Medicine, University of Massachusetts Medical School; B.S. Stolshek, PharmD, Amgen Inc.; S. Rebello, MPH, Corrona LLC; D.H. Collier, MD, Amgen Inc.; A. Mutebi, PhD, Amgen Inc.; S.W. Wade, MPH, Wade Outcomes Research and Consulting; W. Malley, MS, Corrona LLC, and New York University School of Medicine; J.D. Greenberg, MD, MPH, Corrona LLC; C.J. Etzel, PhD, Corrona LLC, and Department of Epidemiology, University of Texas, MD Anderson Cancer Center. Address correspondence to Dr. L.R. Harrold, University of Massachusetts Medical School, Medicine, 55 Lake Ave. North, Worcester, Massachusetts 01655, USA. E-mail: Leslie.Harrold@umassmed.edu. Accepted for publication July 19, 2017.
Wendi Malley
From Corrona LLC, Southborough; Department of Medicine, University of Massachusetts Medical School, Worcester, Massachusetts; Amgen Inc., Thousand Oaks, California; Wade Outcomes Research and Consulting, Salt Lake City, Utah; New York University School of Medicine, New York, New York; Department of Epidemiology, University of Texas, MD Anderson Cancer Center, Houston, Texas, USA. Sponsored by Corrona LLC. Corrona LLC has been supported through contracted subscriptions in the last 2 years by AbbVie, Amgen, BMS, Crescendo, Eli Lilly and Company, Genentech, GSK, Horizon Pharma USA, Janssen, Momenta Pharmaceuticals, Novartis, Pfizer, Roche, and UCB. LRH is an employee and shareholder of Corrona LLC, and has a research grant to the University of Massachusetts Medical School from Pfizer. BSS, DHC, and AM are employees and shareholders of Amgen Inc. SR and WM are employees of Corrona LLC. SWW is a consultant of Amgen Inc. JDG is an employee and shareholder of Corrona LLC, and a consultant of Eli Lilly, Genentech, Janssen, Novartis, and Pfizer. CJE is an employee of Corrona LLC and an advisory board member for Merck. L.R. Harrold, MD, MPH, Corrona LLC, and Department of Medicine, University of Massachusetts Medical School; B.S. Stolshek, PharmD, Amgen Inc.; S. Rebello, MPH, Corrona LLC; D.H. Collier, MD, Amgen Inc.; A. Mutebi, PhD, Amgen Inc.; S.W. Wade, MPH, Wade Outcomes Research and Consulting; W. Malley, MS, Corrona LLC, and New York University School of Medicine; J.D. Greenberg, MD, MPH, Corrona LLC; C.J. Etzel, PhD, Corrona LLC, and Department of Epidemiology, University of Texas, MD Anderson Cancer Center. Address correspondence to Dr. L.R. Harrold, University of Massachusetts Medical School, Medicine, 55 Lake Ave. North, Worcester, Massachusetts 01655, USA. E-mail: Leslie.Harrold@umassmed.edu. Accepted for publication July 19, 2017.
Jeffrey D. Greenberg
From Corrona LLC, Southborough; Department of Medicine, University of Massachusetts Medical School, Worcester, Massachusetts; Amgen Inc., Thousand Oaks, California; Wade Outcomes Research and Consulting, Salt Lake City, Utah; New York University School of Medicine, New York, New York; Department of Epidemiology, University of Texas, MD Anderson Cancer Center, Houston, Texas, USA. Sponsored by Corrona LLC. Corrona LLC has been supported through contracted subscriptions in the last 2 years by AbbVie, Amgen, BMS, Crescendo, Eli Lilly and Company, Genentech, GSK, Horizon Pharma USA, Janssen, Momenta Pharmaceuticals, Novartis, Pfizer, Roche, and UCB. LRH is an employee and shareholder of Corrona LLC, and has a research grant to the University of Massachusetts Medical School from Pfizer. BSS, DHC, and AM are employees and shareholders of Amgen Inc. SR and WM are employees of Corrona LLC. SWW is a consultant of Amgen Inc. JDG is an employee and shareholder of Corrona LLC, and a consultant of Eli Lilly, Genentech, Janssen, Novartis, and Pfizer. CJE is an employee of Corrona LLC and an advisory board member for Merck. L.R. Harrold, MD, MPH, Corrona LLC, and Department of Medicine, University of Massachusetts Medical School; B.S. Stolshek, PharmD, Amgen Inc.; S. Rebello, MPH, Corrona LLC; D.H. Collier, MD, Amgen Inc.; A. Mutebi, PhD, Amgen Inc.; S.W. Wade, MPH, Wade Outcomes Research and Consulting; W. Malley, MS, Corrona LLC, and New York University School of Medicine; J.D. Greenberg, MD, MPH, Corrona LLC; C.J. Etzel, PhD, Corrona LLC, and Department of Epidemiology, University of Texas, MD Anderson Cancer Center. Address correspondence to Dr. L.R. Harrold, University of Massachusetts Medical School, Medicine, 55 Lake Ave. North, Worcester, Massachusetts 01655, USA. E-mail: Leslie.Harrold@umassmed.edu. Accepted for publication July 19, 2017.
Carol J. Etzel
From Corrona LLC, Southborough; Department of Medicine, University of Massachusetts Medical School, Worcester, Massachusetts; Amgen Inc., Thousand Oaks, California; Wade Outcomes Research and Consulting, Salt Lake City, Utah; New York University School of Medicine, New York, New York; Department of Epidemiology, University of Texas, MD Anderson Cancer Center, Houston, Texas, USA. Sponsored by Corrona LLC. Corrona LLC has been supported through contracted subscriptions in the last 2 years by AbbVie, Amgen, BMS, Crescendo, Eli Lilly and Company, Genentech, GSK, Horizon Pharma USA, Janssen, Momenta Pharmaceuticals, Novartis, Pfizer, Roche, and UCB. LRH is an employee and shareholder of Corrona LLC, and has a research grant to the University of Massachusetts Medical School from Pfizer. BSS, DHC, and AM are employees and shareholders of Amgen Inc. SR and WM are employees of Corrona LLC. SWW is a consultant of Amgen Inc. JDG is an employee and shareholder of Corrona LLC, and a consultant of Eli Lilly, Genentech, Janssen, Novartis, and Pfizer. CJE is an employee of Corrona LLC and an advisory board member for Merck. L.R. Harrold, MD, MPH, Corrona LLC, and Department of Medicine, University of Massachusetts Medical School; B.S. Stolshek, PharmD, Amgen Inc.; S. Rebello, MPH, Corrona LLC; D.H. Collier, MD, Amgen Inc.; A. Mutebi, PhD, Amgen Inc.; S.W. Wade, MPH, Wade Outcomes Research and Consulting; W. Malley, MS, Corrona LLC, and New York University School of Medicine; J.D. Greenberg, MD, MPH, Corrona LLC; C.J. Etzel, PhD, Corrona LLC, and Department of Epidemiology, University of Texas, MD Anderson Cancer Center. Address correspondence to Dr. L.R. Harrold, University of Massachusetts Medical School, Medicine, 55 Lake Ave. North, Worcester, Massachusetts 01655, USA. E-mail: Leslie.Harrold@umassmed.edu. Accepted for publication July 19, 2017.
Abstract
Objective Rebound may occur in patients with psoriatic arthritis (PsA) who discontinue TNF inhibitor (TNFi) therapy in low disease activity (LDA).
Methods Using physician and patient reports, we quantified rebound following TNFi discontinuation [defined as Clinical Disease Activity Index (CDAI) score > 10 or TNFi restart] and time to rebound in adults with PsA in LDA (CDAI score ≤ 10) at TNFi discontinuation.
Results Rebound occurred in 73% (69/94) of patients soon after discontinuation (median time to rebound 8.0 mos, 95% CI 6.0–12.0).
Conclusion Rebound occurred frequently in patients with PsA after TNFi discontinuation. TNFi discontinuation after achieving LDA should be carefully considered.
In this issue
The Journal of Rheumatology
Vol. 51, Issue 4
1 Apr 2024
Rebound in Measures of Disease Activity and Symptoms in Corrona Registry Patients with Psoriatic Arthritis Who Discontinue Tumor Necrosis Factor Inhibitor Therapy after Achieving Low Disease Activity
Leslie R. Harrold, Bradley S. Stolshek, Sabrina Rebello, David H. Collier, Alex Mutebi, Sally W. Wade, Wendi Malley, Jeffrey D. Greenberg, Carol J. Etzel
The Journal of Rheumatology Oct 2017, jrheum.161567; DOI: 10.3899/jrheum.161567
Rebound in Measures of Disease Activity and Symptoms in Corrona Registry Patients with Psoriatic Arthritis Who Discontinue Tumor Necrosis Factor Inhibitor Therapy after Achieving Low Disease Activity
Leslie R. Harrold, Bradley S. Stolshek, Sabrina Rebello, David H. Collier, Alex Mutebi, Sally W. Wade, Wendi Malley, Jeffrey D. Greenberg, Carol J. Etzel
The Journal of Rheumatology Oct 2017, jrheum.161567; DOI: 10.3899/jrheum.161567