Research ArticleArticle
The OMERACT Core Domain Set for Outcome Measures for Clinical Trials in Polymyalgia Rheumatica
Sarah L. Mackie, Helen Twohig, Lorna M. Neill, Eileen Harrison, Beverley Shea, Rachel J. Black, Tanaz A. Kermani, Peter A. Merkel, Christian D. Mallen, Frank Buttgereit, Chetan Mukhtyar, Lee S. Simon and Catherine L. Hill on behalf of the OMERACT PMR Working Group
The Journal of Rheumatology August 2017, jrheum.161109; DOI: https://doi.org/10.3899/jrheum.161109
Sarah L. Mackie
From the Leeds Institute of Rheumatic and Musculoskeletal Medicine (LIRMM), University of Leeds, and UK National Institute for Health Research (NIHR), Leeds; Academic Unit of Primary Medical Care, University of Sheffield, Sheffield; PMR-GCA Scotland, Dundee; PMRGCA North East, Gateshead; Primary Care and Health Sciences, Keele University, Keele; Norfolk and Norwich University Hospital, Norwich, UK; Ottawa Hospital Research Institute and School of Epidemiology, Public Health and Preventative Medicine, University of Ottawa, Ottawa, Ontario, Canada; Discipline of Medicine, The University of Adelaide; Rheumatology Unit, The Queen Elizabeth Hospital, Adelaide, Australia; Division of Rheumatology, University of California Los Angeles (UCLA), Los Angeles, California; Division of Rheumatology and Department of Biostatistics and Epidemiology, University of Pennsylvania, Philadelphia, Pennsylvania; SDG LLC, Cambridge, Massachusetts, USA; Department of Rheumatology and Clinical Immunology, Charite University Hospital Berlin, Berlin, Germany. Supported by the NIHR Clinician Scientist Fellowship to Sarah Mackie; unrestricted grant from Horizon Pharmaceuticals. Rachel Black is the recipient of an Australian Rheumatology Association Outcome Measures in Rheumatology (OMERACT) Fellowship 2016. Financial support for patient travel was received from the OMERACT charity DINORA, which received an unrestricted grant from Horizon Pharmaceuticals. S.L. Mackie, BM, BCh, PhD, Associate Clinical Professor and Honorary Consultant Rheumatologist, LIRM, University of Leeds; H. Twohig, MBChB, General Practitioner, Academic Unit of Primary Medical Care, University of Sheffield; L.M. Neill, BSc, PMR-GCA Scotland and OMERACT Patient Research Partner; E. Harrison, BSc, PMR-GCA North East and OMERACT Patient Research Partner; B. Shea, PhD, Senior Methodologist and Adjunct Professor, Ottawa Hospital Research Institute and School of Epidemiology, Public Health and Preventative Medicine, University of Ottawa; R.J. Black, MBBS, Consultant Rheumatologist and Clinical Lecturer, Discipline of Medicine, The University of Adelaide; T.A. Kermani, MD, MS, Assistant Clinical Professor, Division of Rheumatology, UCLA; P.A. Merkel, MD, MPH, Professor of Medicine and Epidemiology, Division of Rheumatology and Department of Biostatistics and Epidemiology, University of Pennsylvania; C.D. Mallen, PhD, NIHR Research Professor in General Practice, Arthritis Research UK Primary Care Centre, Research Institute for Primary Care, Keele University; F. Buttgereit, MD, Professor of Rheumatology, Department of Rheumatology and Clinical Immunology, Charite University Hospital Berlin; C. Mukhtyar, MD, Consultant Rheumatologist, Norfolk and Norwich University Hospital; L.S. Simon, MD, Principal, SDG LLC; C.L. Hill, MD, Clinical Professor and Consultant Rheumatologist, Discipline of Medicine, The University of Adelaide, and Rheumatology Unit, The Queen Elizabeth Hospital. Address correspondence to Dr. S.L. Mackie, Leeds Institute of Rheumatic and Musculoskeletal Medicine, Chapel Allerton Hospital, Leeds, West Yorkshire LS7 4SA, UK. E-mail: s.l.mackie@leeds.ac.uk. Accepted for publication May 12, 2017.
Helen Twohig
From the Leeds Institute of Rheumatic and Musculoskeletal Medicine (LIRMM), University of Leeds, and UK National Institute for Health Research (NIHR), Leeds; Academic Unit of Primary Medical Care, University of Sheffield, Sheffield; PMR-GCA Scotland, Dundee; PMRGCA North East, Gateshead; Primary Care and Health Sciences, Keele University, Keele; Norfolk and Norwich University Hospital, Norwich, UK; Ottawa Hospital Research Institute and School of Epidemiology, Public Health and Preventative Medicine, University of Ottawa, Ottawa, Ontario, Canada; Discipline of Medicine, The University of Adelaide; Rheumatology Unit, The Queen Elizabeth Hospital, Adelaide, Australia; Division of Rheumatology, University of California Los Angeles (UCLA), Los Angeles, California; Division of Rheumatology and Department of Biostatistics and Epidemiology, University of Pennsylvania, Philadelphia, Pennsylvania; SDG LLC, Cambridge, Massachusetts, USA; Department of Rheumatology and Clinical Immunology, Charite University Hospital Berlin, Berlin, Germany. Supported by the NIHR Clinician Scientist Fellowship to Sarah Mackie; unrestricted grant from Horizon Pharmaceuticals. Rachel Black is the recipient of an Australian Rheumatology Association Outcome Measures in Rheumatology (OMERACT) Fellowship 2016. Financial support for patient travel was received from the OMERACT charity DINORA, which received an unrestricted grant from Horizon Pharmaceuticals. S.L. Mackie, BM, BCh, PhD, Associate Clinical Professor and Honorary Consultant Rheumatologist, LIRM, University of Leeds; H. Twohig, MBChB, General Practitioner, Academic Unit of Primary Medical Care, University of Sheffield; L.M. Neill, BSc, PMR-GCA Scotland and OMERACT Patient Research Partner; E. Harrison, BSc, PMR-GCA North East and OMERACT Patient Research Partner; B. Shea, PhD, Senior Methodologist and Adjunct Professor, Ottawa Hospital Research Institute and School of Epidemiology, Public Health and Preventative Medicine, University of Ottawa; R.J. Black, MBBS, Consultant Rheumatologist and Clinical Lecturer, Discipline of Medicine, The University of Adelaide; T.A. Kermani, MD, MS, Assistant Clinical Professor, Division of Rheumatology, UCLA; P.A. Merkel, MD, MPH, Professor of Medicine and Epidemiology, Division of Rheumatology and Department of Biostatistics and Epidemiology, University of Pennsylvania; C.D. Mallen, PhD, NIHR Research Professor in General Practice, Arthritis Research UK Primary Care Centre, Research Institute for Primary Care, Keele University; F. Buttgereit, MD, Professor of Rheumatology, Department of Rheumatology and Clinical Immunology, Charite University Hospital Berlin; C. Mukhtyar, MD, Consultant Rheumatologist, Norfolk and Norwich University Hospital; L.S. Simon, MD, Principal, SDG LLC; C.L. Hill, MD, Clinical Professor and Consultant Rheumatologist, Discipline of Medicine, The University of Adelaide, and Rheumatology Unit, The Queen Elizabeth Hospital. Address correspondence to Dr. S.L. Mackie, Leeds Institute of Rheumatic and Musculoskeletal Medicine, Chapel Allerton Hospital, Leeds, West Yorkshire LS7 4SA, UK. E-mail: s.l.mackie@leeds.ac.uk. Accepted for publication May 12, 2017.
Lorna M. Neill
From the Leeds Institute of Rheumatic and Musculoskeletal Medicine (LIRMM), University of Leeds, and UK National Institute for Health Research (NIHR), Leeds; Academic Unit of Primary Medical Care, University of Sheffield, Sheffield; PMR-GCA Scotland, Dundee; PMRGCA North East, Gateshead; Primary Care and Health Sciences, Keele University, Keele; Norfolk and Norwich University Hospital, Norwich, UK; Ottawa Hospital Research Institute and School of Epidemiology, Public Health and Preventative Medicine, University of Ottawa, Ottawa, Ontario, Canada; Discipline of Medicine, The University of Adelaide; Rheumatology Unit, The Queen Elizabeth Hospital, Adelaide, Australia; Division of Rheumatology, University of California Los Angeles (UCLA), Los Angeles, California; Division of Rheumatology and Department of Biostatistics and Epidemiology, University of Pennsylvania, Philadelphia, Pennsylvania; SDG LLC, Cambridge, Massachusetts, USA; Department of Rheumatology and Clinical Immunology, Charite University Hospital Berlin, Berlin, Germany. Supported by the NIHR Clinician Scientist Fellowship to Sarah Mackie; unrestricted grant from Horizon Pharmaceuticals. Rachel Black is the recipient of an Australian Rheumatology Association Outcome Measures in Rheumatology (OMERACT) Fellowship 2016. Financial support for patient travel was received from the OMERACT charity DINORA, which received an unrestricted grant from Horizon Pharmaceuticals. S.L. Mackie, BM, BCh, PhD, Associate Clinical Professor and Honorary Consultant Rheumatologist, LIRM, University of Leeds; H. Twohig, MBChB, General Practitioner, Academic Unit of Primary Medical Care, University of Sheffield; L.M. Neill, BSc, PMR-GCA Scotland and OMERACT Patient Research Partner; E. Harrison, BSc, PMR-GCA North East and OMERACT Patient Research Partner; B. Shea, PhD, Senior Methodologist and Adjunct Professor, Ottawa Hospital Research Institute and School of Epidemiology, Public Health and Preventative Medicine, University of Ottawa; R.J. Black, MBBS, Consultant Rheumatologist and Clinical Lecturer, Discipline of Medicine, The University of Adelaide; T.A. Kermani, MD, MS, Assistant Clinical Professor, Division of Rheumatology, UCLA; P.A. Merkel, MD, MPH, Professor of Medicine and Epidemiology, Division of Rheumatology and Department of Biostatistics and Epidemiology, University of Pennsylvania; C.D. Mallen, PhD, NIHR Research Professor in General Practice, Arthritis Research UK Primary Care Centre, Research Institute for Primary Care, Keele University; F. Buttgereit, MD, Professor of Rheumatology, Department of Rheumatology and Clinical Immunology, Charite University Hospital Berlin; C. Mukhtyar, MD, Consultant Rheumatologist, Norfolk and Norwich University Hospital; L.S. Simon, MD, Principal, SDG LLC; C.L. Hill, MD, Clinical Professor and Consultant Rheumatologist, Discipline of Medicine, The University of Adelaide, and Rheumatology Unit, The Queen Elizabeth Hospital. Address correspondence to Dr. S.L. Mackie, Leeds Institute of Rheumatic and Musculoskeletal Medicine, Chapel Allerton Hospital, Leeds, West Yorkshire LS7 4SA, UK. E-mail: s.l.mackie@leeds.ac.uk. Accepted for publication May 12, 2017.
Eileen Harrison
From the Leeds Institute of Rheumatic and Musculoskeletal Medicine (LIRMM), University of Leeds, and UK National Institute for Health Research (NIHR), Leeds; Academic Unit of Primary Medical Care, University of Sheffield, Sheffield; PMR-GCA Scotland, Dundee; PMRGCA North East, Gateshead; Primary Care and Health Sciences, Keele University, Keele; Norfolk and Norwich University Hospital, Norwich, UK; Ottawa Hospital Research Institute and School of Epidemiology, Public Health and Preventative Medicine, University of Ottawa, Ottawa, Ontario, Canada; Discipline of Medicine, The University of Adelaide; Rheumatology Unit, The Queen Elizabeth Hospital, Adelaide, Australia; Division of Rheumatology, University of California Los Angeles (UCLA), Los Angeles, California; Division of Rheumatology and Department of Biostatistics and Epidemiology, University of Pennsylvania, Philadelphia, Pennsylvania; SDG LLC, Cambridge, Massachusetts, USA; Department of Rheumatology and Clinical Immunology, Charite University Hospital Berlin, Berlin, Germany. Supported by the NIHR Clinician Scientist Fellowship to Sarah Mackie; unrestricted grant from Horizon Pharmaceuticals. Rachel Black is the recipient of an Australian Rheumatology Association Outcome Measures in Rheumatology (OMERACT) Fellowship 2016. Financial support for patient travel was received from the OMERACT charity DINORA, which received an unrestricted grant from Horizon Pharmaceuticals. S.L. Mackie, BM, BCh, PhD, Associate Clinical Professor and Honorary Consultant Rheumatologist, LIRM, University of Leeds; H. Twohig, MBChB, General Practitioner, Academic Unit of Primary Medical Care, University of Sheffield; L.M. Neill, BSc, PMR-GCA Scotland and OMERACT Patient Research Partner; E. Harrison, BSc, PMR-GCA North East and OMERACT Patient Research Partner; B. Shea, PhD, Senior Methodologist and Adjunct Professor, Ottawa Hospital Research Institute and School of Epidemiology, Public Health and Preventative Medicine, University of Ottawa; R.J. Black, MBBS, Consultant Rheumatologist and Clinical Lecturer, Discipline of Medicine, The University of Adelaide; T.A. Kermani, MD, MS, Assistant Clinical Professor, Division of Rheumatology, UCLA; P.A. Merkel, MD, MPH, Professor of Medicine and Epidemiology, Division of Rheumatology and Department of Biostatistics and Epidemiology, University of Pennsylvania; C.D. Mallen, PhD, NIHR Research Professor in General Practice, Arthritis Research UK Primary Care Centre, Research Institute for Primary Care, Keele University; F. Buttgereit, MD, Professor of Rheumatology, Department of Rheumatology and Clinical Immunology, Charite University Hospital Berlin; C. Mukhtyar, MD, Consultant Rheumatologist, Norfolk and Norwich University Hospital; L.S. Simon, MD, Principal, SDG LLC; C.L. Hill, MD, Clinical Professor and Consultant Rheumatologist, Discipline of Medicine, The University of Adelaide, and Rheumatology Unit, The Queen Elizabeth Hospital. Address correspondence to Dr. S.L. Mackie, Leeds Institute of Rheumatic and Musculoskeletal Medicine, Chapel Allerton Hospital, Leeds, West Yorkshire LS7 4SA, UK. E-mail: s.l.mackie@leeds.ac.uk. Accepted for publication May 12, 2017.
Beverley Shea
From the Leeds Institute of Rheumatic and Musculoskeletal Medicine (LIRMM), University of Leeds, and UK National Institute for Health Research (NIHR), Leeds; Academic Unit of Primary Medical Care, University of Sheffield, Sheffield; PMR-GCA Scotland, Dundee; PMRGCA North East, Gateshead; Primary Care and Health Sciences, Keele University, Keele; Norfolk and Norwich University Hospital, Norwich, UK; Ottawa Hospital Research Institute and School of Epidemiology, Public Health and Preventative Medicine, University of Ottawa, Ottawa, Ontario, Canada; Discipline of Medicine, The University of Adelaide; Rheumatology Unit, The Queen Elizabeth Hospital, Adelaide, Australia; Division of Rheumatology, University of California Los Angeles (UCLA), Los Angeles, California; Division of Rheumatology and Department of Biostatistics and Epidemiology, University of Pennsylvania, Philadelphia, Pennsylvania; SDG LLC, Cambridge, Massachusetts, USA; Department of Rheumatology and Clinical Immunology, Charite University Hospital Berlin, Berlin, Germany. Supported by the NIHR Clinician Scientist Fellowship to Sarah Mackie; unrestricted grant from Horizon Pharmaceuticals. Rachel Black is the recipient of an Australian Rheumatology Association Outcome Measures in Rheumatology (OMERACT) Fellowship 2016. Financial support for patient travel was received from the OMERACT charity DINORA, which received an unrestricted grant from Horizon Pharmaceuticals. S.L. Mackie, BM, BCh, PhD, Associate Clinical Professor and Honorary Consultant Rheumatologist, LIRM, University of Leeds; H. Twohig, MBChB, General Practitioner, Academic Unit of Primary Medical Care, University of Sheffield; L.M. Neill, BSc, PMR-GCA Scotland and OMERACT Patient Research Partner; E. Harrison, BSc, PMR-GCA North East and OMERACT Patient Research Partner; B. Shea, PhD, Senior Methodologist and Adjunct Professor, Ottawa Hospital Research Institute and School of Epidemiology, Public Health and Preventative Medicine, University of Ottawa; R.J. Black, MBBS, Consultant Rheumatologist and Clinical Lecturer, Discipline of Medicine, The University of Adelaide; T.A. Kermani, MD, MS, Assistant Clinical Professor, Division of Rheumatology, UCLA; P.A. Merkel, MD, MPH, Professor of Medicine and Epidemiology, Division of Rheumatology and Department of Biostatistics and Epidemiology, University of Pennsylvania; C.D. Mallen, PhD, NIHR Research Professor in General Practice, Arthritis Research UK Primary Care Centre, Research Institute for Primary Care, Keele University; F. Buttgereit, MD, Professor of Rheumatology, Department of Rheumatology and Clinical Immunology, Charite University Hospital Berlin; C. Mukhtyar, MD, Consultant Rheumatologist, Norfolk and Norwich University Hospital; L.S. Simon, MD, Principal, SDG LLC; C.L. Hill, MD, Clinical Professor and Consultant Rheumatologist, Discipline of Medicine, The University of Adelaide, and Rheumatology Unit, The Queen Elizabeth Hospital. Address correspondence to Dr. S.L. Mackie, Leeds Institute of Rheumatic and Musculoskeletal Medicine, Chapel Allerton Hospital, Leeds, West Yorkshire LS7 4SA, UK. E-mail: s.l.mackie@leeds.ac.uk. Accepted for publication May 12, 2017.
Rachel J. Black
From the Leeds Institute of Rheumatic and Musculoskeletal Medicine (LIRMM), University of Leeds, and UK National Institute for Health Research (NIHR), Leeds; Academic Unit of Primary Medical Care, University of Sheffield, Sheffield; PMR-GCA Scotland, Dundee; PMRGCA North East, Gateshead; Primary Care and Health Sciences, Keele University, Keele; Norfolk and Norwich University Hospital, Norwich, UK; Ottawa Hospital Research Institute and School of Epidemiology, Public Health and Preventative Medicine, University of Ottawa, Ottawa, Ontario, Canada; Discipline of Medicine, The University of Adelaide; Rheumatology Unit, The Queen Elizabeth Hospital, Adelaide, Australia; Division of Rheumatology, University of California Los Angeles (UCLA), Los Angeles, California; Division of Rheumatology and Department of Biostatistics and Epidemiology, University of Pennsylvania, Philadelphia, Pennsylvania; SDG LLC, Cambridge, Massachusetts, USA; Department of Rheumatology and Clinical Immunology, Charite University Hospital Berlin, Berlin, Germany. Supported by the NIHR Clinician Scientist Fellowship to Sarah Mackie; unrestricted grant from Horizon Pharmaceuticals. Rachel Black is the recipient of an Australian Rheumatology Association Outcome Measures in Rheumatology (OMERACT) Fellowship 2016. Financial support for patient travel was received from the OMERACT charity DINORA, which received an unrestricted grant from Horizon Pharmaceuticals. S.L. Mackie, BM, BCh, PhD, Associate Clinical Professor and Honorary Consultant Rheumatologist, LIRM, University of Leeds; H. Twohig, MBChB, General Practitioner, Academic Unit of Primary Medical Care, University of Sheffield; L.M. Neill, BSc, PMR-GCA Scotland and OMERACT Patient Research Partner; E. Harrison, BSc, PMR-GCA North East and OMERACT Patient Research Partner; B. Shea, PhD, Senior Methodologist and Adjunct Professor, Ottawa Hospital Research Institute and School of Epidemiology, Public Health and Preventative Medicine, University of Ottawa; R.J. Black, MBBS, Consultant Rheumatologist and Clinical Lecturer, Discipline of Medicine, The University of Adelaide; T.A. Kermani, MD, MS, Assistant Clinical Professor, Division of Rheumatology, UCLA; P.A. Merkel, MD, MPH, Professor of Medicine and Epidemiology, Division of Rheumatology and Department of Biostatistics and Epidemiology, University of Pennsylvania; C.D. Mallen, PhD, NIHR Research Professor in General Practice, Arthritis Research UK Primary Care Centre, Research Institute for Primary Care, Keele University; F. Buttgereit, MD, Professor of Rheumatology, Department of Rheumatology and Clinical Immunology, Charite University Hospital Berlin; C. Mukhtyar, MD, Consultant Rheumatologist, Norfolk and Norwich University Hospital; L.S. Simon, MD, Principal, SDG LLC; C.L. Hill, MD, Clinical Professor and Consultant Rheumatologist, Discipline of Medicine, The University of Adelaide, and Rheumatology Unit, The Queen Elizabeth Hospital. Address correspondence to Dr. S.L. Mackie, Leeds Institute of Rheumatic and Musculoskeletal Medicine, Chapel Allerton Hospital, Leeds, West Yorkshire LS7 4SA, UK. E-mail: s.l.mackie@leeds.ac.uk. Accepted for publication May 12, 2017.
Tanaz A. Kermani
From the Leeds Institute of Rheumatic and Musculoskeletal Medicine (LIRMM), University of Leeds, and UK National Institute for Health Research (NIHR), Leeds; Academic Unit of Primary Medical Care, University of Sheffield, Sheffield; PMR-GCA Scotland, Dundee; PMRGCA North East, Gateshead; Primary Care and Health Sciences, Keele University, Keele; Norfolk and Norwich University Hospital, Norwich, UK; Ottawa Hospital Research Institute and School of Epidemiology, Public Health and Preventative Medicine, University of Ottawa, Ottawa, Ontario, Canada; Discipline of Medicine, The University of Adelaide; Rheumatology Unit, The Queen Elizabeth Hospital, Adelaide, Australia; Division of Rheumatology, University of California Los Angeles (UCLA), Los Angeles, California; Division of Rheumatology and Department of Biostatistics and Epidemiology, University of Pennsylvania, Philadelphia, Pennsylvania; SDG LLC, Cambridge, Massachusetts, USA; Department of Rheumatology and Clinical Immunology, Charite University Hospital Berlin, Berlin, Germany. Supported by the NIHR Clinician Scientist Fellowship to Sarah Mackie; unrestricted grant from Horizon Pharmaceuticals. Rachel Black is the recipient of an Australian Rheumatology Association Outcome Measures in Rheumatology (OMERACT) Fellowship 2016. Financial support for patient travel was received from the OMERACT charity DINORA, which received an unrestricted grant from Horizon Pharmaceuticals. S.L. Mackie, BM, BCh, PhD, Associate Clinical Professor and Honorary Consultant Rheumatologist, LIRM, University of Leeds; H. Twohig, MBChB, General Practitioner, Academic Unit of Primary Medical Care, University of Sheffield; L.M. Neill, BSc, PMR-GCA Scotland and OMERACT Patient Research Partner; E. Harrison, BSc, PMR-GCA North East and OMERACT Patient Research Partner; B. Shea, PhD, Senior Methodologist and Adjunct Professor, Ottawa Hospital Research Institute and School of Epidemiology, Public Health and Preventative Medicine, University of Ottawa; R.J. Black, MBBS, Consultant Rheumatologist and Clinical Lecturer, Discipline of Medicine, The University of Adelaide; T.A. Kermani, MD, MS, Assistant Clinical Professor, Division of Rheumatology, UCLA; P.A. Merkel, MD, MPH, Professor of Medicine and Epidemiology, Division of Rheumatology and Department of Biostatistics and Epidemiology, University of Pennsylvania; C.D. Mallen, PhD, NIHR Research Professor in General Practice, Arthritis Research UK Primary Care Centre, Research Institute for Primary Care, Keele University; F. Buttgereit, MD, Professor of Rheumatology, Department of Rheumatology and Clinical Immunology, Charite University Hospital Berlin; C. Mukhtyar, MD, Consultant Rheumatologist, Norfolk and Norwich University Hospital; L.S. Simon, MD, Principal, SDG LLC; C.L. Hill, MD, Clinical Professor and Consultant Rheumatologist, Discipline of Medicine, The University of Adelaide, and Rheumatology Unit, The Queen Elizabeth Hospital. Address correspondence to Dr. S.L. Mackie, Leeds Institute of Rheumatic and Musculoskeletal Medicine, Chapel Allerton Hospital, Leeds, West Yorkshire LS7 4SA, UK. E-mail: s.l.mackie@leeds.ac.uk. Accepted for publication May 12, 2017.
Peter A. Merkel
From the Leeds Institute of Rheumatic and Musculoskeletal Medicine (LIRMM), University of Leeds, and UK National Institute for Health Research (NIHR), Leeds; Academic Unit of Primary Medical Care, University of Sheffield, Sheffield; PMR-GCA Scotland, Dundee; PMRGCA North East, Gateshead; Primary Care and Health Sciences, Keele University, Keele; Norfolk and Norwich University Hospital, Norwich, UK; Ottawa Hospital Research Institute and School of Epidemiology, Public Health and Preventative Medicine, University of Ottawa, Ottawa, Ontario, Canada; Discipline of Medicine, The University of Adelaide; Rheumatology Unit, The Queen Elizabeth Hospital, Adelaide, Australia; Division of Rheumatology, University of California Los Angeles (UCLA), Los Angeles, California; Division of Rheumatology and Department of Biostatistics and Epidemiology, University of Pennsylvania, Philadelphia, Pennsylvania; SDG LLC, Cambridge, Massachusetts, USA; Department of Rheumatology and Clinical Immunology, Charite University Hospital Berlin, Berlin, Germany. Supported by the NIHR Clinician Scientist Fellowship to Sarah Mackie; unrestricted grant from Horizon Pharmaceuticals. Rachel Black is the recipient of an Australian Rheumatology Association Outcome Measures in Rheumatology (OMERACT) Fellowship 2016. Financial support for patient travel was received from the OMERACT charity DINORA, which received an unrestricted grant from Horizon Pharmaceuticals. S.L. Mackie, BM, BCh, PhD, Associate Clinical Professor and Honorary Consultant Rheumatologist, LIRM, University of Leeds; H. Twohig, MBChB, General Practitioner, Academic Unit of Primary Medical Care, University of Sheffield; L.M. Neill, BSc, PMR-GCA Scotland and OMERACT Patient Research Partner; E. Harrison, BSc, PMR-GCA North East and OMERACT Patient Research Partner; B. Shea, PhD, Senior Methodologist and Adjunct Professor, Ottawa Hospital Research Institute and School of Epidemiology, Public Health and Preventative Medicine, University of Ottawa; R.J. Black, MBBS, Consultant Rheumatologist and Clinical Lecturer, Discipline of Medicine, The University of Adelaide; T.A. Kermani, MD, MS, Assistant Clinical Professor, Division of Rheumatology, UCLA; P.A. Merkel, MD, MPH, Professor of Medicine and Epidemiology, Division of Rheumatology and Department of Biostatistics and Epidemiology, University of Pennsylvania; C.D. Mallen, PhD, NIHR Research Professor in General Practice, Arthritis Research UK Primary Care Centre, Research Institute for Primary Care, Keele University; F. Buttgereit, MD, Professor of Rheumatology, Department of Rheumatology and Clinical Immunology, Charite University Hospital Berlin; C. Mukhtyar, MD, Consultant Rheumatologist, Norfolk and Norwich University Hospital; L.S. Simon, MD, Principal, SDG LLC; C.L. Hill, MD, Clinical Professor and Consultant Rheumatologist, Discipline of Medicine, The University of Adelaide, and Rheumatology Unit, The Queen Elizabeth Hospital. Address correspondence to Dr. S.L. Mackie, Leeds Institute of Rheumatic and Musculoskeletal Medicine, Chapel Allerton Hospital, Leeds, West Yorkshire LS7 4SA, UK. E-mail: s.l.mackie@leeds.ac.uk. Accepted for publication May 12, 2017.
Christian D. Mallen
From the Leeds Institute of Rheumatic and Musculoskeletal Medicine (LIRMM), University of Leeds, and UK National Institute for Health Research (NIHR), Leeds; Academic Unit of Primary Medical Care, University of Sheffield, Sheffield; PMR-GCA Scotland, Dundee; PMRGCA North East, Gateshead; Primary Care and Health Sciences, Keele University, Keele; Norfolk and Norwich University Hospital, Norwich, UK; Ottawa Hospital Research Institute and School of Epidemiology, Public Health and Preventative Medicine, University of Ottawa, Ottawa, Ontario, Canada; Discipline of Medicine, The University of Adelaide; Rheumatology Unit, The Queen Elizabeth Hospital, Adelaide, Australia; Division of Rheumatology, University of California Los Angeles (UCLA), Los Angeles, California; Division of Rheumatology and Department of Biostatistics and Epidemiology, University of Pennsylvania, Philadelphia, Pennsylvania; SDG LLC, Cambridge, Massachusetts, USA; Department of Rheumatology and Clinical Immunology, Charite University Hospital Berlin, Berlin, Germany. Supported by the NIHR Clinician Scientist Fellowship to Sarah Mackie; unrestricted grant from Horizon Pharmaceuticals. Rachel Black is the recipient of an Australian Rheumatology Association Outcome Measures in Rheumatology (OMERACT) Fellowship 2016. Financial support for patient travel was received from the OMERACT charity DINORA, which received an unrestricted grant from Horizon Pharmaceuticals. S.L. Mackie, BM, BCh, PhD, Associate Clinical Professor and Honorary Consultant Rheumatologist, LIRM, University of Leeds; H. Twohig, MBChB, General Practitioner, Academic Unit of Primary Medical Care, University of Sheffield; L.M. Neill, BSc, PMR-GCA Scotland and OMERACT Patient Research Partner; E. Harrison, BSc, PMR-GCA North East and OMERACT Patient Research Partner; B. Shea, PhD, Senior Methodologist and Adjunct Professor, Ottawa Hospital Research Institute and School of Epidemiology, Public Health and Preventative Medicine, University of Ottawa; R.J. Black, MBBS, Consultant Rheumatologist and Clinical Lecturer, Discipline of Medicine, The University of Adelaide; T.A. Kermani, MD, MS, Assistant Clinical Professor, Division of Rheumatology, UCLA; P.A. Merkel, MD, MPH, Professor of Medicine and Epidemiology, Division of Rheumatology and Department of Biostatistics and Epidemiology, University of Pennsylvania; C.D. Mallen, PhD, NIHR Research Professor in General Practice, Arthritis Research UK Primary Care Centre, Research Institute for Primary Care, Keele University; F. Buttgereit, MD, Professor of Rheumatology, Department of Rheumatology and Clinical Immunology, Charite University Hospital Berlin; C. Mukhtyar, MD, Consultant Rheumatologist, Norfolk and Norwich University Hospital; L.S. Simon, MD, Principal, SDG LLC; C.L. Hill, MD, Clinical Professor and Consultant Rheumatologist, Discipline of Medicine, The University of Adelaide, and Rheumatology Unit, The Queen Elizabeth Hospital. Address correspondence to Dr. S.L. Mackie, Leeds Institute of Rheumatic and Musculoskeletal Medicine, Chapel Allerton Hospital, Leeds, West Yorkshire LS7 4SA, UK. E-mail: s.l.mackie@leeds.ac.uk. Accepted for publication May 12, 2017.
Frank Buttgereit
From the Leeds Institute of Rheumatic and Musculoskeletal Medicine (LIRMM), University of Leeds, and UK National Institute for Health Research (NIHR), Leeds; Academic Unit of Primary Medical Care, University of Sheffield, Sheffield; PMR-GCA Scotland, Dundee; PMRGCA North East, Gateshead; Primary Care and Health Sciences, Keele University, Keele; Norfolk and Norwich University Hospital, Norwich, UK; Ottawa Hospital Research Institute and School of Epidemiology, Public Health and Preventative Medicine, University of Ottawa, Ottawa, Ontario, Canada; Discipline of Medicine, The University of Adelaide; Rheumatology Unit, The Queen Elizabeth Hospital, Adelaide, Australia; Division of Rheumatology, University of California Los Angeles (UCLA), Los Angeles, California; Division of Rheumatology and Department of Biostatistics and Epidemiology, University of Pennsylvania, Philadelphia, Pennsylvania; SDG LLC, Cambridge, Massachusetts, USA; Department of Rheumatology and Clinical Immunology, Charite University Hospital Berlin, Berlin, Germany. Supported by the NIHR Clinician Scientist Fellowship to Sarah Mackie; unrestricted grant from Horizon Pharmaceuticals. Rachel Black is the recipient of an Australian Rheumatology Association Outcome Measures in Rheumatology (OMERACT) Fellowship 2016. Financial support for patient travel was received from the OMERACT charity DINORA, which received an unrestricted grant from Horizon Pharmaceuticals. S.L. Mackie, BM, BCh, PhD, Associate Clinical Professor and Honorary Consultant Rheumatologist, LIRM, University of Leeds; H. Twohig, MBChB, General Practitioner, Academic Unit of Primary Medical Care, University of Sheffield; L.M. Neill, BSc, PMR-GCA Scotland and OMERACT Patient Research Partner; E. Harrison, BSc, PMR-GCA North East and OMERACT Patient Research Partner; B. Shea, PhD, Senior Methodologist and Adjunct Professor, Ottawa Hospital Research Institute and School of Epidemiology, Public Health and Preventative Medicine, University of Ottawa; R.J. Black, MBBS, Consultant Rheumatologist and Clinical Lecturer, Discipline of Medicine, The University of Adelaide; T.A. Kermani, MD, MS, Assistant Clinical Professor, Division of Rheumatology, UCLA; P.A. Merkel, MD, MPH, Professor of Medicine and Epidemiology, Division of Rheumatology and Department of Biostatistics and Epidemiology, University of Pennsylvania; C.D. Mallen, PhD, NIHR Research Professor in General Practice, Arthritis Research UK Primary Care Centre, Research Institute for Primary Care, Keele University; F. Buttgereit, MD, Professor of Rheumatology, Department of Rheumatology and Clinical Immunology, Charite University Hospital Berlin; C. Mukhtyar, MD, Consultant Rheumatologist, Norfolk and Norwich University Hospital; L.S. Simon, MD, Principal, SDG LLC; C.L. Hill, MD, Clinical Professor and Consultant Rheumatologist, Discipline of Medicine, The University of Adelaide, and Rheumatology Unit, The Queen Elizabeth Hospital. Address correspondence to Dr. S.L. Mackie, Leeds Institute of Rheumatic and Musculoskeletal Medicine, Chapel Allerton Hospital, Leeds, West Yorkshire LS7 4SA, UK. E-mail: s.l.mackie@leeds.ac.uk. Accepted for publication May 12, 2017.
Chetan Mukhtyar
From the Leeds Institute of Rheumatic and Musculoskeletal Medicine (LIRMM), University of Leeds, and UK National Institute for Health Research (NIHR), Leeds; Academic Unit of Primary Medical Care, University of Sheffield, Sheffield; PMR-GCA Scotland, Dundee; PMRGCA North East, Gateshead; Primary Care and Health Sciences, Keele University, Keele; Norfolk and Norwich University Hospital, Norwich, UK; Ottawa Hospital Research Institute and School of Epidemiology, Public Health and Preventative Medicine, University of Ottawa, Ottawa, Ontario, Canada; Discipline of Medicine, The University of Adelaide; Rheumatology Unit, The Queen Elizabeth Hospital, Adelaide, Australia; Division of Rheumatology, University of California Los Angeles (UCLA), Los Angeles, California; Division of Rheumatology and Department of Biostatistics and Epidemiology, University of Pennsylvania, Philadelphia, Pennsylvania; SDG LLC, Cambridge, Massachusetts, USA; Department of Rheumatology and Clinical Immunology, Charite University Hospital Berlin, Berlin, Germany. Supported by the NIHR Clinician Scientist Fellowship to Sarah Mackie; unrestricted grant from Horizon Pharmaceuticals. Rachel Black is the recipient of an Australian Rheumatology Association Outcome Measures in Rheumatology (OMERACT) Fellowship 2016. Financial support for patient travel was received from the OMERACT charity DINORA, which received an unrestricted grant from Horizon Pharmaceuticals. S.L. Mackie, BM, BCh, PhD, Associate Clinical Professor and Honorary Consultant Rheumatologist, LIRM, University of Leeds; H. Twohig, MBChB, General Practitioner, Academic Unit of Primary Medical Care, University of Sheffield; L.M. Neill, BSc, PMR-GCA Scotland and OMERACT Patient Research Partner; E. Harrison, BSc, PMR-GCA North East and OMERACT Patient Research Partner; B. Shea, PhD, Senior Methodologist and Adjunct Professor, Ottawa Hospital Research Institute and School of Epidemiology, Public Health and Preventative Medicine, University of Ottawa; R.J. Black, MBBS, Consultant Rheumatologist and Clinical Lecturer, Discipline of Medicine, The University of Adelaide; T.A. Kermani, MD, MS, Assistant Clinical Professor, Division of Rheumatology, UCLA; P.A. Merkel, MD, MPH, Professor of Medicine and Epidemiology, Division of Rheumatology and Department of Biostatistics and Epidemiology, University of Pennsylvania; C.D. Mallen, PhD, NIHR Research Professor in General Practice, Arthritis Research UK Primary Care Centre, Research Institute for Primary Care, Keele University; F. Buttgereit, MD, Professor of Rheumatology, Department of Rheumatology and Clinical Immunology, Charite University Hospital Berlin; C. Mukhtyar, MD, Consultant Rheumatologist, Norfolk and Norwich University Hospital; L.S. Simon, MD, Principal, SDG LLC; C.L. Hill, MD, Clinical Professor and Consultant Rheumatologist, Discipline of Medicine, The University of Adelaide, and Rheumatology Unit, The Queen Elizabeth Hospital. Address correspondence to Dr. S.L. Mackie, Leeds Institute of Rheumatic and Musculoskeletal Medicine, Chapel Allerton Hospital, Leeds, West Yorkshire LS7 4SA, UK. E-mail: s.l.mackie@leeds.ac.uk. Accepted for publication May 12, 2017.
Lee S. Simon
From the Leeds Institute of Rheumatic and Musculoskeletal Medicine (LIRMM), University of Leeds, and UK National Institute for Health Research (NIHR), Leeds; Academic Unit of Primary Medical Care, University of Sheffield, Sheffield; PMR-GCA Scotland, Dundee; PMRGCA North East, Gateshead; Primary Care and Health Sciences, Keele University, Keele; Norfolk and Norwich University Hospital, Norwich, UK; Ottawa Hospital Research Institute and School of Epidemiology, Public Health and Preventative Medicine, University of Ottawa, Ottawa, Ontario, Canada; Discipline of Medicine, The University of Adelaide; Rheumatology Unit, The Queen Elizabeth Hospital, Adelaide, Australia; Division of Rheumatology, University of California Los Angeles (UCLA), Los Angeles, California; Division of Rheumatology and Department of Biostatistics and Epidemiology, University of Pennsylvania, Philadelphia, Pennsylvania; SDG LLC, Cambridge, Massachusetts, USA; Department of Rheumatology and Clinical Immunology, Charite University Hospital Berlin, Berlin, Germany. Supported by the NIHR Clinician Scientist Fellowship to Sarah Mackie; unrestricted grant from Horizon Pharmaceuticals. Rachel Black is the recipient of an Australian Rheumatology Association Outcome Measures in Rheumatology (OMERACT) Fellowship 2016. Financial support for patient travel was received from the OMERACT charity DINORA, which received an unrestricted grant from Horizon Pharmaceuticals. S.L. Mackie, BM, BCh, PhD, Associate Clinical Professor and Honorary Consultant Rheumatologist, LIRM, University of Leeds; H. Twohig, MBChB, General Practitioner, Academic Unit of Primary Medical Care, University of Sheffield; L.M. Neill, BSc, PMR-GCA Scotland and OMERACT Patient Research Partner; E. Harrison, BSc, PMR-GCA North East and OMERACT Patient Research Partner; B. Shea, PhD, Senior Methodologist and Adjunct Professor, Ottawa Hospital Research Institute and School of Epidemiology, Public Health and Preventative Medicine, University of Ottawa; R.J. Black, MBBS, Consultant Rheumatologist and Clinical Lecturer, Discipline of Medicine, The University of Adelaide; T.A. Kermani, MD, MS, Assistant Clinical Professor, Division of Rheumatology, UCLA; P.A. Merkel, MD, MPH, Professor of Medicine and Epidemiology, Division of Rheumatology and Department of Biostatistics and Epidemiology, University of Pennsylvania; C.D. Mallen, PhD, NIHR Research Professor in General Practice, Arthritis Research UK Primary Care Centre, Research Institute for Primary Care, Keele University; F. Buttgereit, MD, Professor of Rheumatology, Department of Rheumatology and Clinical Immunology, Charite University Hospital Berlin; C. Mukhtyar, MD, Consultant Rheumatologist, Norfolk and Norwich University Hospital; L.S. Simon, MD, Principal, SDG LLC; C.L. Hill, MD, Clinical Professor and Consultant Rheumatologist, Discipline of Medicine, The University of Adelaide, and Rheumatology Unit, The Queen Elizabeth Hospital. Address correspondence to Dr. S.L. Mackie, Leeds Institute of Rheumatic and Musculoskeletal Medicine, Chapel Allerton Hospital, Leeds, West Yorkshire LS7 4SA, UK. E-mail: s.l.mackie@leeds.ac.uk. Accepted for publication May 12, 2017.
Catherine L. Hill
From the Leeds Institute of Rheumatic and Musculoskeletal Medicine (LIRMM), University of Leeds, and UK National Institute for Health Research (NIHR), Leeds; Academic Unit of Primary Medical Care, University of Sheffield, Sheffield; PMR-GCA Scotland, Dundee; PMRGCA North East, Gateshead; Primary Care and Health Sciences, Keele University, Keele; Norfolk and Norwich University Hospital, Norwich, UK; Ottawa Hospital Research Institute and School of Epidemiology, Public Health and Preventative Medicine, University of Ottawa, Ottawa, Ontario, Canada; Discipline of Medicine, The University of Adelaide; Rheumatology Unit, The Queen Elizabeth Hospital, Adelaide, Australia; Division of Rheumatology, University of California Los Angeles (UCLA), Los Angeles, California; Division of Rheumatology and Department of Biostatistics and Epidemiology, University of Pennsylvania, Philadelphia, Pennsylvania; SDG LLC, Cambridge, Massachusetts, USA; Department of Rheumatology and Clinical Immunology, Charite University Hospital Berlin, Berlin, Germany. Supported by the NIHR Clinician Scientist Fellowship to Sarah Mackie; unrestricted grant from Horizon Pharmaceuticals. Rachel Black is the recipient of an Australian Rheumatology Association Outcome Measures in Rheumatology (OMERACT) Fellowship 2016. Financial support for patient travel was received from the OMERACT charity DINORA, which received an unrestricted grant from Horizon Pharmaceuticals. S.L. Mackie, BM, BCh, PhD, Associate Clinical Professor and Honorary Consultant Rheumatologist, LIRM, University of Leeds; H. Twohig, MBChB, General Practitioner, Academic Unit of Primary Medical Care, University of Sheffield; L.M. Neill, BSc, PMR-GCA Scotland and OMERACT Patient Research Partner; E. Harrison, BSc, PMR-GCA North East and OMERACT Patient Research Partner; B. Shea, PhD, Senior Methodologist and Adjunct Professor, Ottawa Hospital Research Institute and School of Epidemiology, Public Health and Preventative Medicine, University of Ottawa; R.J. Black, MBBS, Consultant Rheumatologist and Clinical Lecturer, Discipline of Medicine, The University of Adelaide; T.A. Kermani, MD, MS, Assistant Clinical Professor, Division of Rheumatology, UCLA; P.A. Merkel, MD, MPH, Professor of Medicine and Epidemiology, Division of Rheumatology and Department of Biostatistics and Epidemiology, University of Pennsylvania; C.D. Mallen, PhD, NIHR Research Professor in General Practice, Arthritis Research UK Primary Care Centre, Research Institute for Primary Care, Keele University; F. Buttgereit, MD, Professor of Rheumatology, Department of Rheumatology and Clinical Immunology, Charite University Hospital Berlin; C. Mukhtyar, MD, Consultant Rheumatologist, Norfolk and Norwich University Hospital; L.S. Simon, MD, Principal, SDG LLC; C.L. Hill, MD, Clinical Professor and Consultant Rheumatologist, Discipline of Medicine, The University of Adelaide, and Rheumatology Unit, The Queen Elizabeth Hospital. Address correspondence to Dr. S.L. Mackie, Leeds Institute of Rheumatic and Musculoskeletal Medicine, Chapel Allerton Hospital, Leeds, West Yorkshire LS7 4SA, UK. E-mail: s.l.mackie@leeds.ac.uk. Accepted for publication May 12, 2017.
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In this issue
The Journal of Rheumatology
Vol. 51, Issue 3
1 Mar 2024
The OMERACT Core Domain Set for Outcome Measures for Clinical Trials in Polymyalgia Rheumatica
Sarah L. Mackie, Helen Twohig, Lorna M. Neill, Eileen Harrison, Beverley Shea, Rachel J. Black, Tanaz A. Kermani, Peter A. Merkel, Christian D. Mallen, Frank Buttgereit, Chetan Mukhtyar, Lee S. Simon, Catherine L. Hill
The Journal of Rheumatology Aug 2017, jrheum.161109; DOI: 10.3899/jrheum.161109
The OMERACT Core Domain Set for Outcome Measures for Clinical Trials in Polymyalgia Rheumatica
Sarah L. Mackie, Helen Twohig, Lorna M. Neill, Eileen Harrison, Beverley Shea, Rachel J. Black, Tanaz A. Kermani, Peter A. Merkel, Christian D. Mallen, Frank Buttgereit, Chetan Mukhtyar, Lee S. Simon, Catherine L. Hill
The Journal of Rheumatology Aug 2017, jrheum.161109; DOI: 10.3899/jrheum.161109