Research ArticleArticle
Clinical Utility of YKL-40 in Polymyositis/dermatomyositis-associated Interstitial Lung Disease
Hironao Hozumi, Tomoyuki Fujisawa, Noriyuki Enomoto, Ran Nakashima, Yasunori Enomoto, Yuzo Suzuki, Masato Kono, Masato Karayama, Kazuki Furuhashi, Akihiro Murakami, Naoki Inui, Yutaro Nakamura, Tsuneyo Mimori and Takafumi Suda
The Journal of Rheumatology July 2017, jrheum.170373; DOI: https://doi.org/10.3899/jrheum.170373
Hironao Hozumi
From the Second Division, Department of Internal Medicine, Hamamatsu University School of Medicine; Department of Clinical Pharmacology and Therapeutics, Hamamatsu University School of Medicine, Hamamatsu; Department of Rheumatology and Clinical Immunology, Graduate School of Medicine, Kyoto University, Kyoto; Department of IVD Development, Medical and Biological Laboratories Co. Ltd., Ina, Japan. Supported by a grant from the Japan Society for the Promotion of Science (JP16K19449 to H.H.). H. Hozumi, MD, PhD, Research Associate, Second Division, Department of Internal Medicine, Hamamatsu University School of Medicine; T. Fujisawa, MD, PhD, Research Associate, Second Division, Department of Internal Medicine, Hamamatsu University School of Medicine; N. Enomoto, MD, PhD, Lecturer, Second Division, Department of Internal Medicine, Hamamatsu University School of Medicine; R. Nakashima, MD, PhD, Research Associate, Department of Rheumatology and Clinical Immunology, Graduate School of Medicine, Kyoto University; Y. Enomoto, MD, Second Division, Department of Internal Medicine, Hamamatsu University School of Medicine; Y. Suzuki, MD, PhD, Research Associate, Second Division, Department of Internal Medicine, Hamamatsu University School of Medicine; M. Kono, MD, PhD, Research Associate, Second Division, Department of Internal Medicine, Hamamatsu University School of Medicine; M. Karayama, MD, PhD, Lecturer, Second Division, Department of Internal Medicine, Hamamatsu University School of Medicine; K. Furuhashi, MD, PhD, Research Associate, Second Division, Department of Internal Medicine, Hamamatsu University School of Medicine; A. Murakami, PhD, Department of IVD Development, Medical and Biological Laboratories Co. Ltd.; N. Inui, MD, PhD, Assistant Professor, Department of Clinical Pharmacology and Therapeutics, Hamamatsu University School of Medicine; Y. Nakamura, MD, PhD, Lecturer, Second Division, Department of Internal Medicine, Hamamatsu University School of Medicine; T. Mimori, MD, PhD, Professor, Department of Rheumatology and Clinical Immunology, Graduate School of Medicine, Kyoto University; T. Suda, MD, PhD, Professor, Second Division, Department of Internal Medicine, Hamamatsu University School of Medicine. Address correspondence to Dr. H. Hozumi, Second Division, Department of Internal Medicine, Hamamatsu University School of Medicine, 1-20-1 Handayama Higashiku, Hamamatsu 431-3192, Japan. E-mail: jubilooreoresagi@yahoo.co.jp, hozumi@hama-med.ac.jp.Accepted for publication May 13, 2017.
Tomoyuki Fujisawa
From the Second Division, Department of Internal Medicine, Hamamatsu University School of Medicine; Department of Clinical Pharmacology and Therapeutics, Hamamatsu University School of Medicine, Hamamatsu; Department of Rheumatology and Clinical Immunology, Graduate School of Medicine, Kyoto University, Kyoto; Department of IVD Development, Medical and Biological Laboratories Co. Ltd., Ina, Japan. Supported by a grant from the Japan Society for the Promotion of Science (JP16K19449 to H.H.). H. Hozumi, MD, PhD, Research Associate, Second Division, Department of Internal Medicine, Hamamatsu University School of Medicine; T. Fujisawa, MD, PhD, Research Associate, Second Division, Department of Internal Medicine, Hamamatsu University School of Medicine; N. Enomoto, MD, PhD, Lecturer, Second Division, Department of Internal Medicine, Hamamatsu University School of Medicine; R. Nakashima, MD, PhD, Research Associate, Department of Rheumatology and Clinical Immunology, Graduate School of Medicine, Kyoto University; Y. Enomoto, MD, Second Division, Department of Internal Medicine, Hamamatsu University School of Medicine; Y. Suzuki, MD, PhD, Research Associate, Second Division, Department of Internal Medicine, Hamamatsu University School of Medicine; M. Kono, MD, PhD, Research Associate, Second Division, Department of Internal Medicine, Hamamatsu University School of Medicine; M. Karayama, MD, PhD, Lecturer, Second Division, Department of Internal Medicine, Hamamatsu University School of Medicine; K. Furuhashi, MD, PhD, Research Associate, Second Division, Department of Internal Medicine, Hamamatsu University School of Medicine; A. Murakami, PhD, Department of IVD Development, Medical and Biological Laboratories Co. Ltd.; N. Inui, MD, PhD, Assistant Professor, Department of Clinical Pharmacology and Therapeutics, Hamamatsu University School of Medicine; Y. Nakamura, MD, PhD, Lecturer, Second Division, Department of Internal Medicine, Hamamatsu University School of Medicine; T. Mimori, MD, PhD, Professor, Department of Rheumatology and Clinical Immunology, Graduate School of Medicine, Kyoto University; T. Suda, MD, PhD, Professor, Second Division, Department of Internal Medicine, Hamamatsu University School of Medicine. Address correspondence to Dr. H. Hozumi, Second Division, Department of Internal Medicine, Hamamatsu University School of Medicine, 1-20-1 Handayama Higashiku, Hamamatsu 431-3192, Japan. E-mail: jubilooreoresagi@yahoo.co.jp, hozumi@hama-med.ac.jp.Accepted for publication May 13, 2017.
Noriyuki Enomoto
From the Second Division, Department of Internal Medicine, Hamamatsu University School of Medicine; Department of Clinical Pharmacology and Therapeutics, Hamamatsu University School of Medicine, Hamamatsu; Department of Rheumatology and Clinical Immunology, Graduate School of Medicine, Kyoto University, Kyoto; Department of IVD Development, Medical and Biological Laboratories Co. Ltd., Ina, Japan. Supported by a grant from the Japan Society for the Promotion of Science (JP16K19449 to H.H.). H. Hozumi, MD, PhD, Research Associate, Second Division, Department of Internal Medicine, Hamamatsu University School of Medicine; T. Fujisawa, MD, PhD, Research Associate, Second Division, Department of Internal Medicine, Hamamatsu University School of Medicine; N. Enomoto, MD, PhD, Lecturer, Second Division, Department of Internal Medicine, Hamamatsu University School of Medicine; R. Nakashima, MD, PhD, Research Associate, Department of Rheumatology and Clinical Immunology, Graduate School of Medicine, Kyoto University; Y. Enomoto, MD, Second Division, Department of Internal Medicine, Hamamatsu University School of Medicine; Y. Suzuki, MD, PhD, Research Associate, Second Division, Department of Internal Medicine, Hamamatsu University School of Medicine; M. Kono, MD, PhD, Research Associate, Second Division, Department of Internal Medicine, Hamamatsu University School of Medicine; M. Karayama, MD, PhD, Lecturer, Second Division, Department of Internal Medicine, Hamamatsu University School of Medicine; K. Furuhashi, MD, PhD, Research Associate, Second Division, Department of Internal Medicine, Hamamatsu University School of Medicine; A. Murakami, PhD, Department of IVD Development, Medical and Biological Laboratories Co. Ltd.; N. Inui, MD, PhD, Assistant Professor, Department of Clinical Pharmacology and Therapeutics, Hamamatsu University School of Medicine; Y. Nakamura, MD, PhD, Lecturer, Second Division, Department of Internal Medicine, Hamamatsu University School of Medicine; T. Mimori, MD, PhD, Professor, Department of Rheumatology and Clinical Immunology, Graduate School of Medicine, Kyoto University; T. Suda, MD, PhD, Professor, Second Division, Department of Internal Medicine, Hamamatsu University School of Medicine. Address correspondence to Dr. H. Hozumi, Second Division, Department of Internal Medicine, Hamamatsu University School of Medicine, 1-20-1 Handayama Higashiku, Hamamatsu 431-3192, Japan. E-mail: jubilooreoresagi@yahoo.co.jp, hozumi@hama-med.ac.jp.Accepted for publication May 13, 2017.
Ran Nakashima
From the Second Division, Department of Internal Medicine, Hamamatsu University School of Medicine; Department of Clinical Pharmacology and Therapeutics, Hamamatsu University School of Medicine, Hamamatsu; Department of Rheumatology and Clinical Immunology, Graduate School of Medicine, Kyoto University, Kyoto; Department of IVD Development, Medical and Biological Laboratories Co. Ltd., Ina, Japan. Supported by a grant from the Japan Society for the Promotion of Science (JP16K19449 to H.H.). H. Hozumi, MD, PhD, Research Associate, Second Division, Department of Internal Medicine, Hamamatsu University School of Medicine; T. Fujisawa, MD, PhD, Research Associate, Second Division, Department of Internal Medicine, Hamamatsu University School of Medicine; N. Enomoto, MD, PhD, Lecturer, Second Division, Department of Internal Medicine, Hamamatsu University School of Medicine; R. Nakashima, MD, PhD, Research Associate, Department of Rheumatology and Clinical Immunology, Graduate School of Medicine, Kyoto University; Y. Enomoto, MD, Second Division, Department of Internal Medicine, Hamamatsu University School of Medicine; Y. Suzuki, MD, PhD, Research Associate, Second Division, Department of Internal Medicine, Hamamatsu University School of Medicine; M. Kono, MD, PhD, Research Associate, Second Division, Department of Internal Medicine, Hamamatsu University School of Medicine; M. Karayama, MD, PhD, Lecturer, Second Division, Department of Internal Medicine, Hamamatsu University School of Medicine; K. Furuhashi, MD, PhD, Research Associate, Second Division, Department of Internal Medicine, Hamamatsu University School of Medicine; A. Murakami, PhD, Department of IVD Development, Medical and Biological Laboratories Co. Ltd.; N. Inui, MD, PhD, Assistant Professor, Department of Clinical Pharmacology and Therapeutics, Hamamatsu University School of Medicine; Y. Nakamura, MD, PhD, Lecturer, Second Division, Department of Internal Medicine, Hamamatsu University School of Medicine; T. Mimori, MD, PhD, Professor, Department of Rheumatology and Clinical Immunology, Graduate School of Medicine, Kyoto University; T. Suda, MD, PhD, Professor, Second Division, Department of Internal Medicine, Hamamatsu University School of Medicine. Address correspondence to Dr. H. Hozumi, Second Division, Department of Internal Medicine, Hamamatsu University School of Medicine, 1-20-1 Handayama Higashiku, Hamamatsu 431-3192, Japan. E-mail: jubilooreoresagi@yahoo.co.jp, hozumi@hama-med.ac.jp.Accepted for publication May 13, 2017.
Yasunori Enomoto
From the Second Division, Department of Internal Medicine, Hamamatsu University School of Medicine; Department of Clinical Pharmacology and Therapeutics, Hamamatsu University School of Medicine, Hamamatsu; Department of Rheumatology and Clinical Immunology, Graduate School of Medicine, Kyoto University, Kyoto; Department of IVD Development, Medical and Biological Laboratories Co. Ltd., Ina, Japan. Supported by a grant from the Japan Society for the Promotion of Science (JP16K19449 to H.H.). H. Hozumi, MD, PhD, Research Associate, Second Division, Department of Internal Medicine, Hamamatsu University School of Medicine; T. Fujisawa, MD, PhD, Research Associate, Second Division, Department of Internal Medicine, Hamamatsu University School of Medicine; N. Enomoto, MD, PhD, Lecturer, Second Division, Department of Internal Medicine, Hamamatsu University School of Medicine; R. Nakashima, MD, PhD, Research Associate, Department of Rheumatology and Clinical Immunology, Graduate School of Medicine, Kyoto University; Y. Enomoto, MD, Second Division, Department of Internal Medicine, Hamamatsu University School of Medicine; Y. Suzuki, MD, PhD, Research Associate, Second Division, Department of Internal Medicine, Hamamatsu University School of Medicine; M. Kono, MD, PhD, Research Associate, Second Division, Department of Internal Medicine, Hamamatsu University School of Medicine; M. Karayama, MD, PhD, Lecturer, Second Division, Department of Internal Medicine, Hamamatsu University School of Medicine; K. Furuhashi, MD, PhD, Research Associate, Second Division, Department of Internal Medicine, Hamamatsu University School of Medicine; A. Murakami, PhD, Department of IVD Development, Medical and Biological Laboratories Co. Ltd.; N. Inui, MD, PhD, Assistant Professor, Department of Clinical Pharmacology and Therapeutics, Hamamatsu University School of Medicine; Y. Nakamura, MD, PhD, Lecturer, Second Division, Department of Internal Medicine, Hamamatsu University School of Medicine; T. Mimori, MD, PhD, Professor, Department of Rheumatology and Clinical Immunology, Graduate School of Medicine, Kyoto University; T. Suda, MD, PhD, Professor, Second Division, Department of Internal Medicine, Hamamatsu University School of Medicine. Address correspondence to Dr. H. Hozumi, Second Division, Department of Internal Medicine, Hamamatsu University School of Medicine, 1-20-1 Handayama Higashiku, Hamamatsu 431-3192, Japan. E-mail: jubilooreoresagi@yahoo.co.jp, hozumi@hama-med.ac.jp.Accepted for publication May 13, 2017.
Yuzo Suzuki
From the Second Division, Department of Internal Medicine, Hamamatsu University School of Medicine; Department of Clinical Pharmacology and Therapeutics, Hamamatsu University School of Medicine, Hamamatsu; Department of Rheumatology and Clinical Immunology, Graduate School of Medicine, Kyoto University, Kyoto; Department of IVD Development, Medical and Biological Laboratories Co. Ltd., Ina, Japan. Supported by a grant from the Japan Society for the Promotion of Science (JP16K19449 to H.H.). H. Hozumi, MD, PhD, Research Associate, Second Division, Department of Internal Medicine, Hamamatsu University School of Medicine; T. Fujisawa, MD, PhD, Research Associate, Second Division, Department of Internal Medicine, Hamamatsu University School of Medicine; N. Enomoto, MD, PhD, Lecturer, Second Division, Department of Internal Medicine, Hamamatsu University School of Medicine; R. Nakashima, MD, PhD, Research Associate, Department of Rheumatology and Clinical Immunology, Graduate School of Medicine, Kyoto University; Y. Enomoto, MD, Second Division, Department of Internal Medicine, Hamamatsu University School of Medicine; Y. Suzuki, MD, PhD, Research Associate, Second Division, Department of Internal Medicine, Hamamatsu University School of Medicine; M. Kono, MD, PhD, Research Associate, Second Division, Department of Internal Medicine, Hamamatsu University School of Medicine; M. Karayama, MD, PhD, Lecturer, Second Division, Department of Internal Medicine, Hamamatsu University School of Medicine; K. Furuhashi, MD, PhD, Research Associate, Second Division, Department of Internal Medicine, Hamamatsu University School of Medicine; A. Murakami, PhD, Department of IVD Development, Medical and Biological Laboratories Co. Ltd.; N. Inui, MD, PhD, Assistant Professor, Department of Clinical Pharmacology and Therapeutics, Hamamatsu University School of Medicine; Y. Nakamura, MD, PhD, Lecturer, Second Division, Department of Internal Medicine, Hamamatsu University School of Medicine; T. Mimori, MD, PhD, Professor, Department of Rheumatology and Clinical Immunology, Graduate School of Medicine, Kyoto University; T. Suda, MD, PhD, Professor, Second Division, Department of Internal Medicine, Hamamatsu University School of Medicine. Address correspondence to Dr. H. Hozumi, Second Division, Department of Internal Medicine, Hamamatsu University School of Medicine, 1-20-1 Handayama Higashiku, Hamamatsu 431-3192, Japan. E-mail: jubilooreoresagi@yahoo.co.jp, hozumi@hama-med.ac.jp.Accepted for publication May 13, 2017.
Masato Kono
From the Second Division, Department of Internal Medicine, Hamamatsu University School of Medicine; Department of Clinical Pharmacology and Therapeutics, Hamamatsu University School of Medicine, Hamamatsu; Department of Rheumatology and Clinical Immunology, Graduate School of Medicine, Kyoto University, Kyoto; Department of IVD Development, Medical and Biological Laboratories Co. Ltd., Ina, Japan. Supported by a grant from the Japan Society for the Promotion of Science (JP16K19449 to H.H.). H. Hozumi, MD, PhD, Research Associate, Second Division, Department of Internal Medicine, Hamamatsu University School of Medicine; T. Fujisawa, MD, PhD, Research Associate, Second Division, Department of Internal Medicine, Hamamatsu University School of Medicine; N. Enomoto, MD, PhD, Lecturer, Second Division, Department of Internal Medicine, Hamamatsu University School of Medicine; R. Nakashima, MD, PhD, Research Associate, Department of Rheumatology and Clinical Immunology, Graduate School of Medicine, Kyoto University; Y. Enomoto, MD, Second Division, Department of Internal Medicine, Hamamatsu University School of Medicine; Y. Suzuki, MD, PhD, Research Associate, Second Division, Department of Internal Medicine, Hamamatsu University School of Medicine; M. Kono, MD, PhD, Research Associate, Second Division, Department of Internal Medicine, Hamamatsu University School of Medicine; M. Karayama, MD, PhD, Lecturer, Second Division, Department of Internal Medicine, Hamamatsu University School of Medicine; K. Furuhashi, MD, PhD, Research Associate, Second Division, Department of Internal Medicine, Hamamatsu University School of Medicine; A. Murakami, PhD, Department of IVD Development, Medical and Biological Laboratories Co. Ltd.; N. Inui, MD, PhD, Assistant Professor, Department of Clinical Pharmacology and Therapeutics, Hamamatsu University School of Medicine; Y. Nakamura, MD, PhD, Lecturer, Second Division, Department of Internal Medicine, Hamamatsu University School of Medicine; T. Mimori, MD, PhD, Professor, Department of Rheumatology and Clinical Immunology, Graduate School of Medicine, Kyoto University; T. Suda, MD, PhD, Professor, Second Division, Department of Internal Medicine, Hamamatsu University School of Medicine. Address correspondence to Dr. H. Hozumi, Second Division, Department of Internal Medicine, Hamamatsu University School of Medicine, 1-20-1 Handayama Higashiku, Hamamatsu 431-3192, Japan. E-mail: jubilooreoresagi@yahoo.co.jp, hozumi@hama-med.ac.jp.Accepted for publication May 13, 2017.
Masato Karayama
From the Second Division, Department of Internal Medicine, Hamamatsu University School of Medicine; Department of Clinical Pharmacology and Therapeutics, Hamamatsu University School of Medicine, Hamamatsu; Department of Rheumatology and Clinical Immunology, Graduate School of Medicine, Kyoto University, Kyoto; Department of IVD Development, Medical and Biological Laboratories Co. Ltd., Ina, Japan. Supported by a grant from the Japan Society for the Promotion of Science (JP16K19449 to H.H.). H. Hozumi, MD, PhD, Research Associate, Second Division, Department of Internal Medicine, Hamamatsu University School of Medicine; T. Fujisawa, MD, PhD, Research Associate, Second Division, Department of Internal Medicine, Hamamatsu University School of Medicine; N. Enomoto, MD, PhD, Lecturer, Second Division, Department of Internal Medicine, Hamamatsu University School of Medicine; R. Nakashima, MD, PhD, Research Associate, Department of Rheumatology and Clinical Immunology, Graduate School of Medicine, Kyoto University; Y. Enomoto, MD, Second Division, Department of Internal Medicine, Hamamatsu University School of Medicine; Y. Suzuki, MD, PhD, Research Associate, Second Division, Department of Internal Medicine, Hamamatsu University School of Medicine; M. Kono, MD, PhD, Research Associate, Second Division, Department of Internal Medicine, Hamamatsu University School of Medicine; M. Karayama, MD, PhD, Lecturer, Second Division, Department of Internal Medicine, Hamamatsu University School of Medicine; K. Furuhashi, MD, PhD, Research Associate, Second Division, Department of Internal Medicine, Hamamatsu University School of Medicine; A. Murakami, PhD, Department of IVD Development, Medical and Biological Laboratories Co. Ltd.; N. Inui, MD, PhD, Assistant Professor, Department of Clinical Pharmacology and Therapeutics, Hamamatsu University School of Medicine; Y. Nakamura, MD, PhD, Lecturer, Second Division, Department of Internal Medicine, Hamamatsu University School of Medicine; T. Mimori, MD, PhD, Professor, Department of Rheumatology and Clinical Immunology, Graduate School of Medicine, Kyoto University; T. Suda, MD, PhD, Professor, Second Division, Department of Internal Medicine, Hamamatsu University School of Medicine. Address correspondence to Dr. H. Hozumi, Second Division, Department of Internal Medicine, Hamamatsu University School of Medicine, 1-20-1 Handayama Higashiku, Hamamatsu 431-3192, Japan. E-mail: jubilooreoresagi@yahoo.co.jp, hozumi@hama-med.ac.jp.Accepted for publication May 13, 2017.
Kazuki Furuhashi
From the Second Division, Department of Internal Medicine, Hamamatsu University School of Medicine; Department of Clinical Pharmacology and Therapeutics, Hamamatsu University School of Medicine, Hamamatsu; Department of Rheumatology and Clinical Immunology, Graduate School of Medicine, Kyoto University, Kyoto; Department of IVD Development, Medical and Biological Laboratories Co. Ltd., Ina, Japan. Supported by a grant from the Japan Society for the Promotion of Science (JP16K19449 to H.H.). H. Hozumi, MD, PhD, Research Associate, Second Division, Department of Internal Medicine, Hamamatsu University School of Medicine; T. Fujisawa, MD, PhD, Research Associate, Second Division, Department of Internal Medicine, Hamamatsu University School of Medicine; N. Enomoto, MD, PhD, Lecturer, Second Division, Department of Internal Medicine, Hamamatsu University School of Medicine; R. Nakashima, MD, PhD, Research Associate, Department of Rheumatology and Clinical Immunology, Graduate School of Medicine, Kyoto University; Y. Enomoto, MD, Second Division, Department of Internal Medicine, Hamamatsu University School of Medicine; Y. Suzuki, MD, PhD, Research Associate, Second Division, Department of Internal Medicine, Hamamatsu University School of Medicine; M. Kono, MD, PhD, Research Associate, Second Division, Department of Internal Medicine, Hamamatsu University School of Medicine; M. Karayama, MD, PhD, Lecturer, Second Division, Department of Internal Medicine, Hamamatsu University School of Medicine; K. Furuhashi, MD, PhD, Research Associate, Second Division, Department of Internal Medicine, Hamamatsu University School of Medicine; A. Murakami, PhD, Department of IVD Development, Medical and Biological Laboratories Co. Ltd.; N. Inui, MD, PhD, Assistant Professor, Department of Clinical Pharmacology and Therapeutics, Hamamatsu University School of Medicine; Y. Nakamura, MD, PhD, Lecturer, Second Division, Department of Internal Medicine, Hamamatsu University School of Medicine; T. Mimori, MD, PhD, Professor, Department of Rheumatology and Clinical Immunology, Graduate School of Medicine, Kyoto University; T. Suda, MD, PhD, Professor, Second Division, Department of Internal Medicine, Hamamatsu University School of Medicine. Address correspondence to Dr. H. Hozumi, Second Division, Department of Internal Medicine, Hamamatsu University School of Medicine, 1-20-1 Handayama Higashiku, Hamamatsu 431-3192, Japan. E-mail: jubilooreoresagi@yahoo.co.jp, hozumi@hama-med.ac.jp.Accepted for publication May 13, 2017.
Akihiro Murakami
From the Second Division, Department of Internal Medicine, Hamamatsu University School of Medicine; Department of Clinical Pharmacology and Therapeutics, Hamamatsu University School of Medicine, Hamamatsu; Department of Rheumatology and Clinical Immunology, Graduate School of Medicine, Kyoto University, Kyoto; Department of IVD Development, Medical and Biological Laboratories Co. Ltd., Ina, Japan. Supported by a grant from the Japan Society for the Promotion of Science (JP16K19449 to H.H.). H. Hozumi, MD, PhD, Research Associate, Second Division, Department of Internal Medicine, Hamamatsu University School of Medicine; T. Fujisawa, MD, PhD, Research Associate, Second Division, Department of Internal Medicine, Hamamatsu University School of Medicine; N. Enomoto, MD, PhD, Lecturer, Second Division, Department of Internal Medicine, Hamamatsu University School of Medicine; R. Nakashima, MD, PhD, Research Associate, Department of Rheumatology and Clinical Immunology, Graduate School of Medicine, Kyoto University; Y. Enomoto, MD, Second Division, Department of Internal Medicine, Hamamatsu University School of Medicine; Y. Suzuki, MD, PhD, Research Associate, Second Division, Department of Internal Medicine, Hamamatsu University School of Medicine; M. Kono, MD, PhD, Research Associate, Second Division, Department of Internal Medicine, Hamamatsu University School of Medicine; M. Karayama, MD, PhD, Lecturer, Second Division, Department of Internal Medicine, Hamamatsu University School of Medicine; K. Furuhashi, MD, PhD, Research Associate, Second Division, Department of Internal Medicine, Hamamatsu University School of Medicine; A. Murakami, PhD, Department of IVD Development, Medical and Biological Laboratories Co. Ltd.; N. Inui, MD, PhD, Assistant Professor, Department of Clinical Pharmacology and Therapeutics, Hamamatsu University School of Medicine; Y. Nakamura, MD, PhD, Lecturer, Second Division, Department of Internal Medicine, Hamamatsu University School of Medicine; T. Mimori, MD, PhD, Professor, Department of Rheumatology and Clinical Immunology, Graduate School of Medicine, Kyoto University; T. Suda, MD, PhD, Professor, Second Division, Department of Internal Medicine, Hamamatsu University School of Medicine. Address correspondence to Dr. H. Hozumi, Second Division, Department of Internal Medicine, Hamamatsu University School of Medicine, 1-20-1 Handayama Higashiku, Hamamatsu 431-3192, Japan. E-mail: jubilooreoresagi@yahoo.co.jp, hozumi@hama-med.ac.jp.Accepted for publication May 13, 2017.
Naoki Inui
From the Second Division, Department of Internal Medicine, Hamamatsu University School of Medicine; Department of Clinical Pharmacology and Therapeutics, Hamamatsu University School of Medicine, Hamamatsu; Department of Rheumatology and Clinical Immunology, Graduate School of Medicine, Kyoto University, Kyoto; Department of IVD Development, Medical and Biological Laboratories Co. Ltd., Ina, Japan. Supported by a grant from the Japan Society for the Promotion of Science (JP16K19449 to H.H.). H. Hozumi, MD, PhD, Research Associate, Second Division, Department of Internal Medicine, Hamamatsu University School of Medicine; T. Fujisawa, MD, PhD, Research Associate, Second Division, Department of Internal Medicine, Hamamatsu University School of Medicine; N. Enomoto, MD, PhD, Lecturer, Second Division, Department of Internal Medicine, Hamamatsu University School of Medicine; R. Nakashima, MD, PhD, Research Associate, Department of Rheumatology and Clinical Immunology, Graduate School of Medicine, Kyoto University; Y. Enomoto, MD, Second Division, Department of Internal Medicine, Hamamatsu University School of Medicine; Y. Suzuki, MD, PhD, Research Associate, Second Division, Department of Internal Medicine, Hamamatsu University School of Medicine; M. Kono, MD, PhD, Research Associate, Second Division, Department of Internal Medicine, Hamamatsu University School of Medicine; M. Karayama, MD, PhD, Lecturer, Second Division, Department of Internal Medicine, Hamamatsu University School of Medicine; K. Furuhashi, MD, PhD, Research Associate, Second Division, Department of Internal Medicine, Hamamatsu University School of Medicine; A. Murakami, PhD, Department of IVD Development, Medical and Biological Laboratories Co. Ltd.; N. Inui, MD, PhD, Assistant Professor, Department of Clinical Pharmacology and Therapeutics, Hamamatsu University School of Medicine; Y. Nakamura, MD, PhD, Lecturer, Second Division, Department of Internal Medicine, Hamamatsu University School of Medicine; T. Mimori, MD, PhD, Professor, Department of Rheumatology and Clinical Immunology, Graduate School of Medicine, Kyoto University; T. Suda, MD, PhD, Professor, Second Division, Department of Internal Medicine, Hamamatsu University School of Medicine. Address correspondence to Dr. H. Hozumi, Second Division, Department of Internal Medicine, Hamamatsu University School of Medicine, 1-20-1 Handayama Higashiku, Hamamatsu 431-3192, Japan. E-mail: jubilooreoresagi@yahoo.co.jp, hozumi@hama-med.ac.jp.Accepted for publication May 13, 2017.
Yutaro Nakamura
From the Second Division, Department of Internal Medicine, Hamamatsu University School of Medicine; Department of Clinical Pharmacology and Therapeutics, Hamamatsu University School of Medicine, Hamamatsu; Department of Rheumatology and Clinical Immunology, Graduate School of Medicine, Kyoto University, Kyoto; Department of IVD Development, Medical and Biological Laboratories Co. Ltd., Ina, Japan. Supported by a grant from the Japan Society for the Promotion of Science (JP16K19449 to H.H.). H. Hozumi, MD, PhD, Research Associate, Second Division, Department of Internal Medicine, Hamamatsu University School of Medicine; T. Fujisawa, MD, PhD, Research Associate, Second Division, Department of Internal Medicine, Hamamatsu University School of Medicine; N. Enomoto, MD, PhD, Lecturer, Second Division, Department of Internal Medicine, Hamamatsu University School of Medicine; R. Nakashima, MD, PhD, Research Associate, Department of Rheumatology and Clinical Immunology, Graduate School of Medicine, Kyoto University; Y. Enomoto, MD, Second Division, Department of Internal Medicine, Hamamatsu University School of Medicine; Y. Suzuki, MD, PhD, Research Associate, Second Division, Department of Internal Medicine, Hamamatsu University School of Medicine; M. Kono, MD, PhD, Research Associate, Second Division, Department of Internal Medicine, Hamamatsu University School of Medicine; M. Karayama, MD, PhD, Lecturer, Second Division, Department of Internal Medicine, Hamamatsu University School of Medicine; K. Furuhashi, MD, PhD, Research Associate, Second Division, Department of Internal Medicine, Hamamatsu University School of Medicine; A. Murakami, PhD, Department of IVD Development, Medical and Biological Laboratories Co. Ltd.; N. Inui, MD, PhD, Assistant Professor, Department of Clinical Pharmacology and Therapeutics, Hamamatsu University School of Medicine; Y. Nakamura, MD, PhD, Lecturer, Second Division, Department of Internal Medicine, Hamamatsu University School of Medicine; T. Mimori, MD, PhD, Professor, Department of Rheumatology and Clinical Immunology, Graduate School of Medicine, Kyoto University; T. Suda, MD, PhD, Professor, Second Division, Department of Internal Medicine, Hamamatsu University School of Medicine. Address correspondence to Dr. H. Hozumi, Second Division, Department of Internal Medicine, Hamamatsu University School of Medicine, 1-20-1 Handayama Higashiku, Hamamatsu 431-3192, Japan. E-mail: jubilooreoresagi@yahoo.co.jp, hozumi@hama-med.ac.jp.Accepted for publication May 13, 2017.
Tsuneyo Mimori
From the Second Division, Department of Internal Medicine, Hamamatsu University School of Medicine; Department of Clinical Pharmacology and Therapeutics, Hamamatsu University School of Medicine, Hamamatsu; Department of Rheumatology and Clinical Immunology, Graduate School of Medicine, Kyoto University, Kyoto; Department of IVD Development, Medical and Biological Laboratories Co. Ltd., Ina, Japan. Supported by a grant from the Japan Society for the Promotion of Science (JP16K19449 to H.H.). H. Hozumi, MD, PhD, Research Associate, Second Division, Department of Internal Medicine, Hamamatsu University School of Medicine; T. Fujisawa, MD, PhD, Research Associate, Second Division, Department of Internal Medicine, Hamamatsu University School of Medicine; N. Enomoto, MD, PhD, Lecturer, Second Division, Department of Internal Medicine, Hamamatsu University School of Medicine; R. Nakashima, MD, PhD, Research Associate, Department of Rheumatology and Clinical Immunology, Graduate School of Medicine, Kyoto University; Y. Enomoto, MD, Second Division, Department of Internal Medicine, Hamamatsu University School of Medicine; Y. Suzuki, MD, PhD, Research Associate, Second Division, Department of Internal Medicine, Hamamatsu University School of Medicine; M. Kono, MD, PhD, Research Associate, Second Division, Department of Internal Medicine, Hamamatsu University School of Medicine; M. Karayama, MD, PhD, Lecturer, Second Division, Department of Internal Medicine, Hamamatsu University School of Medicine; K. Furuhashi, MD, PhD, Research Associate, Second Division, Department of Internal Medicine, Hamamatsu University School of Medicine; A. Murakami, PhD, Department of IVD Development, Medical and Biological Laboratories Co. Ltd.; N. Inui, MD, PhD, Assistant Professor, Department of Clinical Pharmacology and Therapeutics, Hamamatsu University School of Medicine; Y. Nakamura, MD, PhD, Lecturer, Second Division, Department of Internal Medicine, Hamamatsu University School of Medicine; T. Mimori, MD, PhD, Professor, Department of Rheumatology and Clinical Immunology, Graduate School of Medicine, Kyoto University; T. Suda, MD, PhD, Professor, Second Division, Department of Internal Medicine, Hamamatsu University School of Medicine. Address correspondence to Dr. H. Hozumi, Second Division, Department of Internal Medicine, Hamamatsu University School of Medicine, 1-20-1 Handayama Higashiku, Hamamatsu 431-3192, Japan. E-mail: jubilooreoresagi@yahoo.co.jp, hozumi@hama-med.ac.jp.Accepted for publication May 13, 2017.
Takafumi Suda
From the Second Division, Department of Internal Medicine, Hamamatsu University School of Medicine; Department of Clinical Pharmacology and Therapeutics, Hamamatsu University School of Medicine, Hamamatsu; Department of Rheumatology and Clinical Immunology, Graduate School of Medicine, Kyoto University, Kyoto; Department of IVD Development, Medical and Biological Laboratories Co. Ltd., Ina, Japan. Supported by a grant from the Japan Society for the Promotion of Science (JP16K19449 to H.H.). H. Hozumi, MD, PhD, Research Associate, Second Division, Department of Internal Medicine, Hamamatsu University School of Medicine; T. Fujisawa, MD, PhD, Research Associate, Second Division, Department of Internal Medicine, Hamamatsu University School of Medicine; N. Enomoto, MD, PhD, Lecturer, Second Division, Department of Internal Medicine, Hamamatsu University School of Medicine; R. Nakashima, MD, PhD, Research Associate, Department of Rheumatology and Clinical Immunology, Graduate School of Medicine, Kyoto University; Y. Enomoto, MD, Second Division, Department of Internal Medicine, Hamamatsu University School of Medicine; Y. Suzuki, MD, PhD, Research Associate, Second Division, Department of Internal Medicine, Hamamatsu University School of Medicine; M. Kono, MD, PhD, Research Associate, Second Division, Department of Internal Medicine, Hamamatsu University School of Medicine; M. Karayama, MD, PhD, Lecturer, Second Division, Department of Internal Medicine, Hamamatsu University School of Medicine; K. Furuhashi, MD, PhD, Research Associate, Second Division, Department of Internal Medicine, Hamamatsu University School of Medicine; A. Murakami, PhD, Department of IVD Development, Medical and Biological Laboratories Co. Ltd.; N. Inui, MD, PhD, Assistant Professor, Department of Clinical Pharmacology and Therapeutics, Hamamatsu University School of Medicine; Y. Nakamura, MD, PhD, Lecturer, Second Division, Department of Internal Medicine, Hamamatsu University School of Medicine; T. Mimori, MD, PhD, Professor, Department of Rheumatology and Clinical Immunology, Graduate School of Medicine, Kyoto University; T. Suda, MD, PhD, Professor, Second Division, Department of Internal Medicine, Hamamatsu University School of Medicine. Address correspondence to Dr. H. Hozumi, Second Division, Department of Internal Medicine, Hamamatsu University School of Medicine, 1-20-1 Handayama Higashiku, Hamamatsu 431-3192, Japan. E-mail: jubilooreoresagi@yahoo.co.jp, hozumi@hama-med.ac.jp.Accepted for publication May 13, 2017.
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- Published online July 15, 2017.
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© 2017 The Journal of Rheumatology
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- Hironao Hozumi,
- Tomoyuki Fujisawa,
- Noriyuki Enomoto,
- Ran Nakashima,
- Yasunori Enomoto,
- Yuzo Suzuki,
- Masato Kono,
- Masato Karayama,
- Kazuki Furuhashi,
- Akihiro Murakami,
- Naoki Inui,
- Yutaro Nakamura,
- Tsuneyo Mimori and
- Takafumi Suda
- From the Second Division, Department of Internal Medicine, Hamamatsu University School of Medicine; Department of Clinical Pharmacology and Therapeutics, Hamamatsu University School of Medicine, Hamamatsu; Department of Rheumatology and Clinical Immunology, Graduate School of Medicine, Kyoto University, Kyoto; Department of IVD Development, Medical and Biological Laboratories Co. Ltd., Ina, Japan.
Supported by a grant from the Japan Society for the Promotion of Science (JP16K19449 to H.H.).
H. Hozumi, MD, PhD, Research Associate, Second Division, Department of Internal Medicine, Hamamatsu University School of Medicine; T. Fujisawa, MD, PhD, Research Associate, Second Division, Department of Internal Medicine, Hamamatsu University School of Medicine; N. Enomoto, MD, PhD, Lecturer, Second Division, Department of Internal Medicine, Hamamatsu University School of Medicine; R. Nakashima, MD, PhD, Research Associate, Department of Rheumatology and Clinical Immunology, Graduate School of Medicine, Kyoto University; Y. Enomoto, MD, Second Division, Department of Internal Medicine, Hamamatsu University School of Medicine; Y. Suzuki, MD, PhD, Research Associate, Second Division, Department of Internal Medicine, Hamamatsu University School of Medicine; M. Kono, MD, PhD, Research Associate, Second Division, Department of Internal Medicine, Hamamatsu University School of Medicine; M. Karayama, MD, PhD, Lecturer, Second Division, Department of Internal Medicine, Hamamatsu University School of Medicine; K. Furuhashi, MD, PhD, Research Associate, Second Division, Department of Internal Medicine, Hamamatsu University School of Medicine; A. Murakami, PhD, Department of IVD Development, Medical and Biological Laboratories Co. Ltd.; N. Inui, MD, PhD, Assistant Professor, Department of Clinical Pharmacology and Therapeutics, Hamamatsu University School of Medicine; Y. Nakamura, MD, PhD, Lecturer, Second Division, Department of Internal Medicine, Hamamatsu University School of Medicine; T. Mimori, MD, PhD, Professor, Department of Rheumatology and Clinical Immunology, Graduate School of Medicine, Kyoto University; T. Suda, MD, PhD, Professor, Second Division, Department of Internal Medicine, Hamamatsu University School of Medicine.
Address correspondence to Dr. H. Hozumi, Second Division, Department of Internal Medicine, Hamamatsu University School of Medicine, 1-20-1 Handayama Higashiku, Hamamatsu 431-3192, Japan. E-mail: jubilooreoresagi@yahoo.co.jp, hozumi@hama-med.ac.jp.
Accepted for publication May 13, 2017.
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The Journal of Rheumatology Jul 2017, jrheum.170373; DOI: 10.3899/jrheum.170373