Research ArticleArticle
HLA-DRB1 Alleles as Genetic Risk Factors for the Development of Anti-MDA5 Antibodies in Patients with Dermatomyositis
Zhiyong Chen, Yan Wang, Masataka Kuwana, Xue Xu, Wei Hu, Xuebing Feng, Hong Wang, Akinori Kimura and Lingyun Sun
The Journal of Rheumatology July 2017, jrheum.170165; DOI: https://doi.org/10.3899/jrheum.170165
Zhiyong Chen
From the Department of Rheumatology and Immunology, and Department of Clinical Laboratory, the Affiliated Drum Tower Hospital, Nanjing University Medical School, Nanjing, China; Department of Allergy and Rheumatology, Nippon Medical School Graduate School of Medicine; Department of Molecular Pathogenesis, Medical Research Institute, Tokyo Medical and Dental University, Tokyo, Japan. Supported by the National Natural Science Foundation of China (to ZC, NO. 81302556). Key Project supported by Medical Science and Technology Development Foundation, Nanjing Department of Health (to ZC, NO. ZKX16039). Z. Chen, MD, PhD, Department of Rheumatology and Immunology, the Affiliated Drum Tower Hospital, Nanjing University Medical School; Y. Wang, MD, Department of Rheumatology and Immunology, the Affiliated Drum Tower Hospital, Nanjing University Medical School; M. Kuwana, MD, PhD, Department of Allergy and Rheumatology, Nippon Medical School Graduate School of Medicine; X. Xu, MD, PhD, Department of Rheumatology and Immunology, the Affiliated Drum Tower Hospital, Nanjing University Medical School; W. Hu, MD, Department of Clinical Laboratory, the Affiliated Drum Tower Hospital, Nanjing University Medical School; X. Feng, MD, PhD, Department of Rheumatology and Immunology, the Affiliated Drum Tower Hospital, Nanjing University Medical School; H. Wang, MD, Department of Rheumatology and Immunology, the Affiliated Drum Tower Hospital, Nanjing University Medical School; A. Kimura, MD, PhD, Department of Molecular Pathogenesis, Medical Research Institute, Tokyo Medical and Dental University; L. Sun, MD, PhD, Department of Rheumatology and Immunology, the Affiliated Drum Tower Hospital, Nanjing University Medical School. Address correspondence to Dr. A. Kimura, Department of Molecular Pathogenesis, Medical Research Institute, Tokyo Medical and Dental University, 1-5-45 Yushima, Bunkyo-ku, Tokyo 113-8510, Japan. E-mail: akitis@mri.tmd.ac.jp; or Dr. L. Sun, Department of Rheumatology and Immunology, Drum Tower Clinical College of Nanjing Medical University, 321 Zhongshan Road, Nanjing, 210008, China. E-mail: lingyunsun2012@163.com. Accepted for publication May 25, 2017.
Yan Wang
From the Department of Rheumatology and Immunology, and Department of Clinical Laboratory, the Affiliated Drum Tower Hospital, Nanjing University Medical School, Nanjing, China; Department of Allergy and Rheumatology, Nippon Medical School Graduate School of Medicine; Department of Molecular Pathogenesis, Medical Research Institute, Tokyo Medical and Dental University, Tokyo, Japan. Supported by the National Natural Science Foundation of China (to ZC, NO. 81302556). Key Project supported by Medical Science and Technology Development Foundation, Nanjing Department of Health (to ZC, NO. ZKX16039). Z. Chen, MD, PhD, Department of Rheumatology and Immunology, the Affiliated Drum Tower Hospital, Nanjing University Medical School; Y. Wang, MD, Department of Rheumatology and Immunology, the Affiliated Drum Tower Hospital, Nanjing University Medical School; M. Kuwana, MD, PhD, Department of Allergy and Rheumatology, Nippon Medical School Graduate School of Medicine; X. Xu, MD, PhD, Department of Rheumatology and Immunology, the Affiliated Drum Tower Hospital, Nanjing University Medical School; W. Hu, MD, Department of Clinical Laboratory, the Affiliated Drum Tower Hospital, Nanjing University Medical School; X. Feng, MD, PhD, Department of Rheumatology and Immunology, the Affiliated Drum Tower Hospital, Nanjing University Medical School; H. Wang, MD, Department of Rheumatology and Immunology, the Affiliated Drum Tower Hospital, Nanjing University Medical School; A. Kimura, MD, PhD, Department of Molecular Pathogenesis, Medical Research Institute, Tokyo Medical and Dental University; L. Sun, MD, PhD, Department of Rheumatology and Immunology, the Affiliated Drum Tower Hospital, Nanjing University Medical School. Address correspondence to Dr. A. Kimura, Department of Molecular Pathogenesis, Medical Research Institute, Tokyo Medical and Dental University, 1-5-45 Yushima, Bunkyo-ku, Tokyo 113-8510, Japan. E-mail: akitis@mri.tmd.ac.jp; or Dr. L. Sun, Department of Rheumatology and Immunology, Drum Tower Clinical College of Nanjing Medical University, 321 Zhongshan Road, Nanjing, 210008, China. E-mail: lingyunsun2012@163.com. Accepted for publication May 25, 2017.
Masataka Kuwana
From the Department of Rheumatology and Immunology, and Department of Clinical Laboratory, the Affiliated Drum Tower Hospital, Nanjing University Medical School, Nanjing, China; Department of Allergy and Rheumatology, Nippon Medical School Graduate School of Medicine; Department of Molecular Pathogenesis, Medical Research Institute, Tokyo Medical and Dental University, Tokyo, Japan. Supported by the National Natural Science Foundation of China (to ZC, NO. 81302556). Key Project supported by Medical Science and Technology Development Foundation, Nanjing Department of Health (to ZC, NO. ZKX16039). Z. Chen, MD, PhD, Department of Rheumatology and Immunology, the Affiliated Drum Tower Hospital, Nanjing University Medical School; Y. Wang, MD, Department of Rheumatology and Immunology, the Affiliated Drum Tower Hospital, Nanjing University Medical School; M. Kuwana, MD, PhD, Department of Allergy and Rheumatology, Nippon Medical School Graduate School of Medicine; X. Xu, MD, PhD, Department of Rheumatology and Immunology, the Affiliated Drum Tower Hospital, Nanjing University Medical School; W. Hu, MD, Department of Clinical Laboratory, the Affiliated Drum Tower Hospital, Nanjing University Medical School; X. Feng, MD, PhD, Department of Rheumatology and Immunology, the Affiliated Drum Tower Hospital, Nanjing University Medical School; H. Wang, MD, Department of Rheumatology and Immunology, the Affiliated Drum Tower Hospital, Nanjing University Medical School; A. Kimura, MD, PhD, Department of Molecular Pathogenesis, Medical Research Institute, Tokyo Medical and Dental University; L. Sun, MD, PhD, Department of Rheumatology and Immunology, the Affiliated Drum Tower Hospital, Nanjing University Medical School. Address correspondence to Dr. A. Kimura, Department of Molecular Pathogenesis, Medical Research Institute, Tokyo Medical and Dental University, 1-5-45 Yushima, Bunkyo-ku, Tokyo 113-8510, Japan. E-mail: akitis@mri.tmd.ac.jp; or Dr. L. Sun, Department of Rheumatology and Immunology, Drum Tower Clinical College of Nanjing Medical University, 321 Zhongshan Road, Nanjing, 210008, China. E-mail: lingyunsun2012@163.com. Accepted for publication May 25, 2017.
Xue Xu
From the Department of Rheumatology and Immunology, and Department of Clinical Laboratory, the Affiliated Drum Tower Hospital, Nanjing University Medical School, Nanjing, China; Department of Allergy and Rheumatology, Nippon Medical School Graduate School of Medicine; Department of Molecular Pathogenesis, Medical Research Institute, Tokyo Medical and Dental University, Tokyo, Japan. Supported by the National Natural Science Foundation of China (to ZC, NO. 81302556). Key Project supported by Medical Science and Technology Development Foundation, Nanjing Department of Health (to ZC, NO. ZKX16039). Z. Chen, MD, PhD, Department of Rheumatology and Immunology, the Affiliated Drum Tower Hospital, Nanjing University Medical School; Y. Wang, MD, Department of Rheumatology and Immunology, the Affiliated Drum Tower Hospital, Nanjing University Medical School; M. Kuwana, MD, PhD, Department of Allergy and Rheumatology, Nippon Medical School Graduate School of Medicine; X. Xu, MD, PhD, Department of Rheumatology and Immunology, the Affiliated Drum Tower Hospital, Nanjing University Medical School; W. Hu, MD, Department of Clinical Laboratory, the Affiliated Drum Tower Hospital, Nanjing University Medical School; X. Feng, MD, PhD, Department of Rheumatology and Immunology, the Affiliated Drum Tower Hospital, Nanjing University Medical School; H. Wang, MD, Department of Rheumatology and Immunology, the Affiliated Drum Tower Hospital, Nanjing University Medical School; A. Kimura, MD, PhD, Department of Molecular Pathogenesis, Medical Research Institute, Tokyo Medical and Dental University; L. Sun, MD, PhD, Department of Rheumatology and Immunology, the Affiliated Drum Tower Hospital, Nanjing University Medical School. Address correspondence to Dr. A. Kimura, Department of Molecular Pathogenesis, Medical Research Institute, Tokyo Medical and Dental University, 1-5-45 Yushima, Bunkyo-ku, Tokyo 113-8510, Japan. E-mail: akitis@mri.tmd.ac.jp; or Dr. L. Sun, Department of Rheumatology and Immunology, Drum Tower Clinical College of Nanjing Medical University, 321 Zhongshan Road, Nanjing, 210008, China. E-mail: lingyunsun2012@163.com. Accepted for publication May 25, 2017.
Wei Hu
From the Department of Rheumatology and Immunology, and Department of Clinical Laboratory, the Affiliated Drum Tower Hospital, Nanjing University Medical School, Nanjing, China; Department of Allergy and Rheumatology, Nippon Medical School Graduate School of Medicine; Department of Molecular Pathogenesis, Medical Research Institute, Tokyo Medical and Dental University, Tokyo, Japan. Supported by the National Natural Science Foundation of China (to ZC, NO. 81302556). Key Project supported by Medical Science and Technology Development Foundation, Nanjing Department of Health (to ZC, NO. ZKX16039). Z. Chen, MD, PhD, Department of Rheumatology and Immunology, the Affiliated Drum Tower Hospital, Nanjing University Medical School; Y. Wang, MD, Department of Rheumatology and Immunology, the Affiliated Drum Tower Hospital, Nanjing University Medical School; M. Kuwana, MD, PhD, Department of Allergy and Rheumatology, Nippon Medical School Graduate School of Medicine; X. Xu, MD, PhD, Department of Rheumatology and Immunology, the Affiliated Drum Tower Hospital, Nanjing University Medical School; W. Hu, MD, Department of Clinical Laboratory, the Affiliated Drum Tower Hospital, Nanjing University Medical School; X. Feng, MD, PhD, Department of Rheumatology and Immunology, the Affiliated Drum Tower Hospital, Nanjing University Medical School; H. Wang, MD, Department of Rheumatology and Immunology, the Affiliated Drum Tower Hospital, Nanjing University Medical School; A. Kimura, MD, PhD, Department of Molecular Pathogenesis, Medical Research Institute, Tokyo Medical and Dental University; L. Sun, MD, PhD, Department of Rheumatology and Immunology, the Affiliated Drum Tower Hospital, Nanjing University Medical School. Address correspondence to Dr. A. Kimura, Department of Molecular Pathogenesis, Medical Research Institute, Tokyo Medical and Dental University, 1-5-45 Yushima, Bunkyo-ku, Tokyo 113-8510, Japan. E-mail: akitis@mri.tmd.ac.jp; or Dr. L. Sun, Department of Rheumatology and Immunology, Drum Tower Clinical College of Nanjing Medical University, 321 Zhongshan Road, Nanjing, 210008, China. E-mail: lingyunsun2012@163.com. Accepted for publication May 25, 2017.
Xuebing Feng
From the Department of Rheumatology and Immunology, and Department of Clinical Laboratory, the Affiliated Drum Tower Hospital, Nanjing University Medical School, Nanjing, China; Department of Allergy and Rheumatology, Nippon Medical School Graduate School of Medicine; Department of Molecular Pathogenesis, Medical Research Institute, Tokyo Medical and Dental University, Tokyo, Japan. Supported by the National Natural Science Foundation of China (to ZC, NO. 81302556). Key Project supported by Medical Science and Technology Development Foundation, Nanjing Department of Health (to ZC, NO. ZKX16039). Z. Chen, MD, PhD, Department of Rheumatology and Immunology, the Affiliated Drum Tower Hospital, Nanjing University Medical School; Y. Wang, MD, Department of Rheumatology and Immunology, the Affiliated Drum Tower Hospital, Nanjing University Medical School; M. Kuwana, MD, PhD, Department of Allergy and Rheumatology, Nippon Medical School Graduate School of Medicine; X. Xu, MD, PhD, Department of Rheumatology and Immunology, the Affiliated Drum Tower Hospital, Nanjing University Medical School; W. Hu, MD, Department of Clinical Laboratory, the Affiliated Drum Tower Hospital, Nanjing University Medical School; X. Feng, MD, PhD, Department of Rheumatology and Immunology, the Affiliated Drum Tower Hospital, Nanjing University Medical School; H. Wang, MD, Department of Rheumatology and Immunology, the Affiliated Drum Tower Hospital, Nanjing University Medical School; A. Kimura, MD, PhD, Department of Molecular Pathogenesis, Medical Research Institute, Tokyo Medical and Dental University; L. Sun, MD, PhD, Department of Rheumatology and Immunology, the Affiliated Drum Tower Hospital, Nanjing University Medical School. Address correspondence to Dr. A. Kimura, Department of Molecular Pathogenesis, Medical Research Institute, Tokyo Medical and Dental University, 1-5-45 Yushima, Bunkyo-ku, Tokyo 113-8510, Japan. E-mail: akitis@mri.tmd.ac.jp; or Dr. L. Sun, Department of Rheumatology and Immunology, Drum Tower Clinical College of Nanjing Medical University, 321 Zhongshan Road, Nanjing, 210008, China. E-mail: lingyunsun2012@163.com. Accepted for publication May 25, 2017.
Hong Wang
From the Department of Rheumatology and Immunology, and Department of Clinical Laboratory, the Affiliated Drum Tower Hospital, Nanjing University Medical School, Nanjing, China; Department of Allergy and Rheumatology, Nippon Medical School Graduate School of Medicine; Department of Molecular Pathogenesis, Medical Research Institute, Tokyo Medical and Dental University, Tokyo, Japan. Supported by the National Natural Science Foundation of China (to ZC, NO. 81302556). Key Project supported by Medical Science and Technology Development Foundation, Nanjing Department of Health (to ZC, NO. ZKX16039). Z. Chen, MD, PhD, Department of Rheumatology and Immunology, the Affiliated Drum Tower Hospital, Nanjing University Medical School; Y. Wang, MD, Department of Rheumatology and Immunology, the Affiliated Drum Tower Hospital, Nanjing University Medical School; M. Kuwana, MD, PhD, Department of Allergy and Rheumatology, Nippon Medical School Graduate School of Medicine; X. Xu, MD, PhD, Department of Rheumatology and Immunology, the Affiliated Drum Tower Hospital, Nanjing University Medical School; W. Hu, MD, Department of Clinical Laboratory, the Affiliated Drum Tower Hospital, Nanjing University Medical School; X. Feng, MD, PhD, Department of Rheumatology and Immunology, the Affiliated Drum Tower Hospital, Nanjing University Medical School; H. Wang, MD, Department of Rheumatology and Immunology, the Affiliated Drum Tower Hospital, Nanjing University Medical School; A. Kimura, MD, PhD, Department of Molecular Pathogenesis, Medical Research Institute, Tokyo Medical and Dental University; L. Sun, MD, PhD, Department of Rheumatology and Immunology, the Affiliated Drum Tower Hospital, Nanjing University Medical School. Address correspondence to Dr. A. Kimura, Department of Molecular Pathogenesis, Medical Research Institute, Tokyo Medical and Dental University, 1-5-45 Yushima, Bunkyo-ku, Tokyo 113-8510, Japan. E-mail: akitis@mri.tmd.ac.jp; or Dr. L. Sun, Department of Rheumatology and Immunology, Drum Tower Clinical College of Nanjing Medical University, 321 Zhongshan Road, Nanjing, 210008, China. E-mail: lingyunsun2012@163.com. Accepted for publication May 25, 2017.
Akinori Kimura
From the Department of Rheumatology and Immunology, and Department of Clinical Laboratory, the Affiliated Drum Tower Hospital, Nanjing University Medical School, Nanjing, China; Department of Allergy and Rheumatology, Nippon Medical School Graduate School of Medicine; Department of Molecular Pathogenesis, Medical Research Institute, Tokyo Medical and Dental University, Tokyo, Japan. Supported by the National Natural Science Foundation of China (to ZC, NO. 81302556). Key Project supported by Medical Science and Technology Development Foundation, Nanjing Department of Health (to ZC, NO. ZKX16039). Z. Chen, MD, PhD, Department of Rheumatology and Immunology, the Affiliated Drum Tower Hospital, Nanjing University Medical School; Y. Wang, MD, Department of Rheumatology and Immunology, the Affiliated Drum Tower Hospital, Nanjing University Medical School; M. Kuwana, MD, PhD, Department of Allergy and Rheumatology, Nippon Medical School Graduate School of Medicine; X. Xu, MD, PhD, Department of Rheumatology and Immunology, the Affiliated Drum Tower Hospital, Nanjing University Medical School; W. Hu, MD, Department of Clinical Laboratory, the Affiliated Drum Tower Hospital, Nanjing University Medical School; X. Feng, MD, PhD, Department of Rheumatology and Immunology, the Affiliated Drum Tower Hospital, Nanjing University Medical School; H. Wang, MD, Department of Rheumatology and Immunology, the Affiliated Drum Tower Hospital, Nanjing University Medical School; A. Kimura, MD, PhD, Department of Molecular Pathogenesis, Medical Research Institute, Tokyo Medical and Dental University; L. Sun, MD, PhD, Department of Rheumatology and Immunology, the Affiliated Drum Tower Hospital, Nanjing University Medical School. Address correspondence to Dr. A. Kimura, Department of Molecular Pathogenesis, Medical Research Institute, Tokyo Medical and Dental University, 1-5-45 Yushima, Bunkyo-ku, Tokyo 113-8510, Japan. E-mail: akitis@mri.tmd.ac.jp; or Dr. L. Sun, Department of Rheumatology and Immunology, Drum Tower Clinical College of Nanjing Medical University, 321 Zhongshan Road, Nanjing, 210008, China. E-mail: lingyunsun2012@163.com. Accepted for publication May 25, 2017.
Lingyun Sun
From the Department of Rheumatology and Immunology, and Department of Clinical Laboratory, the Affiliated Drum Tower Hospital, Nanjing University Medical School, Nanjing, China; Department of Allergy and Rheumatology, Nippon Medical School Graduate School of Medicine; Department of Molecular Pathogenesis, Medical Research Institute, Tokyo Medical and Dental University, Tokyo, Japan. Supported by the National Natural Science Foundation of China (to ZC, NO. 81302556). Key Project supported by Medical Science and Technology Development Foundation, Nanjing Department of Health (to ZC, NO. ZKX16039). Z. Chen, MD, PhD, Department of Rheumatology and Immunology, the Affiliated Drum Tower Hospital, Nanjing University Medical School; Y. Wang, MD, Department of Rheumatology and Immunology, the Affiliated Drum Tower Hospital, Nanjing University Medical School; M. Kuwana, MD, PhD, Department of Allergy and Rheumatology, Nippon Medical School Graduate School of Medicine; X. Xu, MD, PhD, Department of Rheumatology and Immunology, the Affiliated Drum Tower Hospital, Nanjing University Medical School; W. Hu, MD, Department of Clinical Laboratory, the Affiliated Drum Tower Hospital, Nanjing University Medical School; X. Feng, MD, PhD, Department of Rheumatology and Immunology, the Affiliated Drum Tower Hospital, Nanjing University Medical School; H. Wang, MD, Department of Rheumatology and Immunology, the Affiliated Drum Tower Hospital, Nanjing University Medical School; A. Kimura, MD, PhD, Department of Molecular Pathogenesis, Medical Research Institute, Tokyo Medical and Dental University; L. Sun, MD, PhD, Department of Rheumatology and Immunology, the Affiliated Drum Tower Hospital, Nanjing University Medical School. Address correspondence to Dr. A. Kimura, Department of Molecular Pathogenesis, Medical Research Institute, Tokyo Medical and Dental University, 1-5-45 Yushima, Bunkyo-ku, Tokyo 113-8510, Japan. E-mail: akitis@mri.tmd.ac.jp; or Dr. L. Sun, Department of Rheumatology and Immunology, Drum Tower Clinical College of Nanjing Medical University, 321 Zhongshan Road, Nanjing, 210008, China. E-mail: lingyunsun2012@163.com. Accepted for publication May 25, 2017.
Published eLetters
eLetters are comments published online only and are not peer-reviewed. Publication of eLetter submissions is not guaranteed, and all submissions are reviewed and edited at the discretion of The Journal's staff.
If you wish to publish Letters to the Editor or Correspondence, please submit through our online submission system ScholarOne Manuscripts.
Jump to comment:
No eLetters have been published for this article.
In this issue
The Journal of Rheumatology
Vol. 51, Issue 4
1 Apr 2024
HLA-DRB1 Alleles as Genetic Risk Factors for the Development of Anti-MDA5 Antibodies in Patients with Dermatomyositis
Zhiyong Chen, Yan Wang, Masataka Kuwana, Xue Xu, Wei Hu, Xuebing Feng, Hong Wang, Akinori Kimura, Lingyun Sun
The Journal of Rheumatology Jul 2017, jrheum.170165; DOI: 10.3899/jrheum.170165
HLA-DRB1 Alleles as Genetic Risk Factors for the Development of Anti-MDA5 Antibodies in Patients with Dermatomyositis
Zhiyong Chen, Yan Wang, Masataka Kuwana, Xue Xu, Wei Hu, Xuebing Feng, Hong Wang, Akinori Kimura, Lingyun Sun
The Journal of Rheumatology Jul 2017, jrheum.170165; DOI: 10.3899/jrheum.170165