Research ArticleArticle
Longterm Outcome of Patients with Primary Antiphospholipid Syndrome: A Retrospective Multicenter Study
Mara Taraborelli, Rossella Reggia, Francesca Dall’Ara, Micaela Fredi, Laura Andreoli, Maria Gerosa, Ariela Hoxha, Laura Massaro, Marta Tonello, Nathalie Costedoat-Chalumeau, Patrice Cacoub, Franco Franceschini, Pier Luigi Meroni, Jean Charles Piette, Amelia Ruffatti, Guido Valesini, Eon Nigel Harris and Angela Tincani
The Journal of Rheumatology June 2017, jrheum.161364; DOI: https://doi.org/10.3899/jrheum.161364
Mara Taraborelli
From the Rheumatology and Clinical Immunology Department, Spedali Civili and University of Brescia, Brescia; Division of Rheumatology, Department of Clinical Sciences and Community Health, Ospedale Gaetano Pini, University of Milan, Milan; Rheumatology Unit, Department of Medicine - DIMED, University of Padua, Padua; Internal Medicine and Medical Specialties Department, Policlinico Umberto I, La Sapienza University of Rome, Rome, Italy; AP-HP, Hôpital Cochin, Centre de référence maladies auto-immunes et systémiques rares, Service de Médecine Interne; AP-HP, Hospital Pitié-Salpêtrière, Centre de référence maladies auto-immunes et systémiques rares, Service de Médecine Interne, Pierre et Marie Curie Paris VI University, Paris, France; University of the West Indies, Kingston, Jamaica. M. Taraborelli, MD, Rheumatology and Clinical Immunology Department, Spedali Civili and University of Brescia; R. Reggia, MD, Rheumatology and Clinical Immunology Department, Spedali Civili and University of Brescia; F. Dall’Ara, MD, Rheumatology and Clinical Immunology Department, Spedali Civili and University of Brescia; M. Fredi, MD, Rheumatology and Clinical Immunology Department, Spedali Civili and University of Brescia; L. Andreoli, MD, PhD, Rheumatology and Clinical Immunology Department, Spedali Civili and University of Brescia; M. Gerosa, MD, PhD, Division of Rheumatology, Department of Clinical Sciences and Community Health, Ospedale Gaetano Pini, University of Milan; A. Hoxha, MD, PhD, Rheumatology Unit, Department of Medicine - DIMED, University of Padua; L. Massaro, MD, Internal Medicine and Medical Specialties Department, Policlinico Umberto I, La Sapienza University of Rome; M. Tonello, BSc, PhD, Rheumatology Unit, Department of Medicine - DIMED, University of Padua; N. Costedoat-Chalumeau, MD, PhD, AP-HP, Hôpital Cochin, Centre de référence maladies auto-immunes et systémiques rares, Service de Médecine Interne; P. Cacoub, MD, PhD, AP-HP, Hospital Pitié-Salpêtrière, Centre de référence maladies auto-immunes et systémiques rares, Service de Médecine Interne, Pierre et Marie Curie Paris VI University; F. Franceschini, MD, Rheumatology and Clinical Immunology Department, Spedali Civili and University of Brescia; P.L. Meroni, MD, Division of Rheumatology, Department of Clinical Sciences and Community Health, Ospedale Gaetano Pini, University of Milan; J.C. Piette, MD, PhD, AP-HP, Hospital Pitié-Salpêtrière, Centre de référence maladies auto-immunes et systémiques rares, Service de Médecine Interne, Pierre et Marie Curie Paris VI University; A. Ruffatti, MD, PhD, Rheumatology Unit, Department of Medicine - DIMED, University of Padua; G. Valesini, MD, Internal Medicine and Medical Specialties Department, Policlinico Umberto I, La Sapienza University of Rome; E.N. Harris, MPhil, MD, DM, Vice Chancellor Emeritus, University of the West Indies; A. Tincani, MD, Rheumatology and Clinical Immunology Department, Spedali Civili and University of Brescia. Drs. Taraborelli, Reggia, and Dall’Ara contributed equally to this paper. Address correspondence to Dr. A. Tincani, Rheumatology and Clinical Immunology Unit, Spedali Civili of Brescia, Piazzale Spedali Civili 1, 25123 Brescia, Italy. E-mail: angela.tincani@unibs.it. Accepted for publication April 12, 2017.
Rossella Reggia
From the Rheumatology and Clinical Immunology Department, Spedali Civili and University of Brescia, Brescia; Division of Rheumatology, Department of Clinical Sciences and Community Health, Ospedale Gaetano Pini, University of Milan, Milan; Rheumatology Unit, Department of Medicine - DIMED, University of Padua, Padua; Internal Medicine and Medical Specialties Department, Policlinico Umberto I, La Sapienza University of Rome, Rome, Italy; AP-HP, Hôpital Cochin, Centre de référence maladies auto-immunes et systémiques rares, Service de Médecine Interne; AP-HP, Hospital Pitié-Salpêtrière, Centre de référence maladies auto-immunes et systémiques rares, Service de Médecine Interne, Pierre et Marie Curie Paris VI University, Paris, France; University of the West Indies, Kingston, Jamaica. M. Taraborelli, MD, Rheumatology and Clinical Immunology Department, Spedali Civili and University of Brescia; R. Reggia, MD, Rheumatology and Clinical Immunology Department, Spedali Civili and University of Brescia; F. Dall’Ara, MD, Rheumatology and Clinical Immunology Department, Spedali Civili and University of Brescia; M. Fredi, MD, Rheumatology and Clinical Immunology Department, Spedali Civili and University of Brescia; L. Andreoli, MD, PhD, Rheumatology and Clinical Immunology Department, Spedali Civili and University of Brescia; M. Gerosa, MD, PhD, Division of Rheumatology, Department of Clinical Sciences and Community Health, Ospedale Gaetano Pini, University of Milan; A. Hoxha, MD, PhD, Rheumatology Unit, Department of Medicine - DIMED, University of Padua; L. Massaro, MD, Internal Medicine and Medical Specialties Department, Policlinico Umberto I, La Sapienza University of Rome; M. Tonello, BSc, PhD, Rheumatology Unit, Department of Medicine - DIMED, University of Padua; N. Costedoat-Chalumeau, MD, PhD, AP-HP, Hôpital Cochin, Centre de référence maladies auto-immunes et systémiques rares, Service de Médecine Interne; P. Cacoub, MD, PhD, AP-HP, Hospital Pitié-Salpêtrière, Centre de référence maladies auto-immunes et systémiques rares, Service de Médecine Interne, Pierre et Marie Curie Paris VI University; F. Franceschini, MD, Rheumatology and Clinical Immunology Department, Spedali Civili and University of Brescia; P.L. Meroni, MD, Division of Rheumatology, Department of Clinical Sciences and Community Health, Ospedale Gaetano Pini, University of Milan; J.C. Piette, MD, PhD, AP-HP, Hospital Pitié-Salpêtrière, Centre de référence maladies auto-immunes et systémiques rares, Service de Médecine Interne, Pierre et Marie Curie Paris VI University; A. Ruffatti, MD, PhD, Rheumatology Unit, Department of Medicine - DIMED, University of Padua; G. Valesini, MD, Internal Medicine and Medical Specialties Department, Policlinico Umberto I, La Sapienza University of Rome; E.N. Harris, MPhil, MD, DM, Vice Chancellor Emeritus, University of the West Indies; A. Tincani, MD, Rheumatology and Clinical Immunology Department, Spedali Civili and University of Brescia. Drs. Taraborelli, Reggia, and Dall’Ara contributed equally to this paper. Address correspondence to Dr. A. Tincani, Rheumatology and Clinical Immunology Unit, Spedali Civili of Brescia, Piazzale Spedali Civili 1, 25123 Brescia, Italy. E-mail: angela.tincani@unibs.it. Accepted for publication April 12, 2017.
Francesca Dall’Ara
From the Rheumatology and Clinical Immunology Department, Spedali Civili and University of Brescia, Brescia; Division of Rheumatology, Department of Clinical Sciences and Community Health, Ospedale Gaetano Pini, University of Milan, Milan; Rheumatology Unit, Department of Medicine - DIMED, University of Padua, Padua; Internal Medicine and Medical Specialties Department, Policlinico Umberto I, La Sapienza University of Rome, Rome, Italy; AP-HP, Hôpital Cochin, Centre de référence maladies auto-immunes et systémiques rares, Service de Médecine Interne; AP-HP, Hospital Pitié-Salpêtrière, Centre de référence maladies auto-immunes et systémiques rares, Service de Médecine Interne, Pierre et Marie Curie Paris VI University, Paris, France; University of the West Indies, Kingston, Jamaica. M. Taraborelli, MD, Rheumatology and Clinical Immunology Department, Spedali Civili and University of Brescia; R. Reggia, MD, Rheumatology and Clinical Immunology Department, Spedali Civili and University of Brescia; F. Dall’Ara, MD, Rheumatology and Clinical Immunology Department, Spedali Civili and University of Brescia; M. Fredi, MD, Rheumatology and Clinical Immunology Department, Spedali Civili and University of Brescia; L. Andreoli, MD, PhD, Rheumatology and Clinical Immunology Department, Spedali Civili and University of Brescia; M. Gerosa, MD, PhD, Division of Rheumatology, Department of Clinical Sciences and Community Health, Ospedale Gaetano Pini, University of Milan; A. Hoxha, MD, PhD, Rheumatology Unit, Department of Medicine - DIMED, University of Padua; L. Massaro, MD, Internal Medicine and Medical Specialties Department, Policlinico Umberto I, La Sapienza University of Rome; M. Tonello, BSc, PhD, Rheumatology Unit, Department of Medicine - DIMED, University of Padua; N. Costedoat-Chalumeau, MD, PhD, AP-HP, Hôpital Cochin, Centre de référence maladies auto-immunes et systémiques rares, Service de Médecine Interne; P. Cacoub, MD, PhD, AP-HP, Hospital Pitié-Salpêtrière, Centre de référence maladies auto-immunes et systémiques rares, Service de Médecine Interne, Pierre et Marie Curie Paris VI University; F. Franceschini, MD, Rheumatology and Clinical Immunology Department, Spedali Civili and University of Brescia; P.L. Meroni, MD, Division of Rheumatology, Department of Clinical Sciences and Community Health, Ospedale Gaetano Pini, University of Milan; J.C. Piette, MD, PhD, AP-HP, Hospital Pitié-Salpêtrière, Centre de référence maladies auto-immunes et systémiques rares, Service de Médecine Interne, Pierre et Marie Curie Paris VI University; A. Ruffatti, MD, PhD, Rheumatology Unit, Department of Medicine - DIMED, University of Padua; G. Valesini, MD, Internal Medicine and Medical Specialties Department, Policlinico Umberto I, La Sapienza University of Rome; E.N. Harris, MPhil, MD, DM, Vice Chancellor Emeritus, University of the West Indies; A. Tincani, MD, Rheumatology and Clinical Immunology Department, Spedali Civili and University of Brescia. Drs. Taraborelli, Reggia, and Dall’Ara contributed equally to this paper. Address correspondence to Dr. A. Tincani, Rheumatology and Clinical Immunology Unit, Spedali Civili of Brescia, Piazzale Spedali Civili 1, 25123 Brescia, Italy. E-mail: angela.tincani@unibs.it. Accepted for publication April 12, 2017.
Micaela Fredi
From the Rheumatology and Clinical Immunology Department, Spedali Civili and University of Brescia, Brescia; Division of Rheumatology, Department of Clinical Sciences and Community Health, Ospedale Gaetano Pini, University of Milan, Milan; Rheumatology Unit, Department of Medicine - DIMED, University of Padua, Padua; Internal Medicine and Medical Specialties Department, Policlinico Umberto I, La Sapienza University of Rome, Rome, Italy; AP-HP, Hôpital Cochin, Centre de référence maladies auto-immunes et systémiques rares, Service de Médecine Interne; AP-HP, Hospital Pitié-Salpêtrière, Centre de référence maladies auto-immunes et systémiques rares, Service de Médecine Interne, Pierre et Marie Curie Paris VI University, Paris, France; University of the West Indies, Kingston, Jamaica. M. Taraborelli, MD, Rheumatology and Clinical Immunology Department, Spedali Civili and University of Brescia; R. Reggia, MD, Rheumatology and Clinical Immunology Department, Spedali Civili and University of Brescia; F. Dall’Ara, MD, Rheumatology and Clinical Immunology Department, Spedali Civili and University of Brescia; M. Fredi, MD, Rheumatology and Clinical Immunology Department, Spedali Civili and University of Brescia; L. Andreoli, MD, PhD, Rheumatology and Clinical Immunology Department, Spedali Civili and University of Brescia; M. Gerosa, MD, PhD, Division of Rheumatology, Department of Clinical Sciences and Community Health, Ospedale Gaetano Pini, University of Milan; A. Hoxha, MD, PhD, Rheumatology Unit, Department of Medicine - DIMED, University of Padua; L. Massaro, MD, Internal Medicine and Medical Specialties Department, Policlinico Umberto I, La Sapienza University of Rome; M. Tonello, BSc, PhD, Rheumatology Unit, Department of Medicine - DIMED, University of Padua; N. Costedoat-Chalumeau, MD, PhD, AP-HP, Hôpital Cochin, Centre de référence maladies auto-immunes et systémiques rares, Service de Médecine Interne; P. Cacoub, MD, PhD, AP-HP, Hospital Pitié-Salpêtrière, Centre de référence maladies auto-immunes et systémiques rares, Service de Médecine Interne, Pierre et Marie Curie Paris VI University; F. Franceschini, MD, Rheumatology and Clinical Immunology Department, Spedali Civili and University of Brescia; P.L. Meroni, MD, Division of Rheumatology, Department of Clinical Sciences and Community Health, Ospedale Gaetano Pini, University of Milan; J.C. Piette, MD, PhD, AP-HP, Hospital Pitié-Salpêtrière, Centre de référence maladies auto-immunes et systémiques rares, Service de Médecine Interne, Pierre et Marie Curie Paris VI University; A. Ruffatti, MD, PhD, Rheumatology Unit, Department of Medicine - DIMED, University of Padua; G. Valesini, MD, Internal Medicine and Medical Specialties Department, Policlinico Umberto I, La Sapienza University of Rome; E.N. Harris, MPhil, MD, DM, Vice Chancellor Emeritus, University of the West Indies; A. Tincani, MD, Rheumatology and Clinical Immunology Department, Spedali Civili and University of Brescia. Drs. Taraborelli, Reggia, and Dall’Ara contributed equally to this paper. Address correspondence to Dr. A. Tincani, Rheumatology and Clinical Immunology Unit, Spedali Civili of Brescia, Piazzale Spedali Civili 1, 25123 Brescia, Italy. E-mail: angela.tincani@unibs.it. Accepted for publication April 12, 2017.
Laura Andreoli
From the Rheumatology and Clinical Immunology Department, Spedali Civili and University of Brescia, Brescia; Division of Rheumatology, Department of Clinical Sciences and Community Health, Ospedale Gaetano Pini, University of Milan, Milan; Rheumatology Unit, Department of Medicine - DIMED, University of Padua, Padua; Internal Medicine and Medical Specialties Department, Policlinico Umberto I, La Sapienza University of Rome, Rome, Italy; AP-HP, Hôpital Cochin, Centre de référence maladies auto-immunes et systémiques rares, Service de Médecine Interne; AP-HP, Hospital Pitié-Salpêtrière, Centre de référence maladies auto-immunes et systémiques rares, Service de Médecine Interne, Pierre et Marie Curie Paris VI University, Paris, France; University of the West Indies, Kingston, Jamaica. M. Taraborelli, MD, Rheumatology and Clinical Immunology Department, Spedali Civili and University of Brescia; R. Reggia, MD, Rheumatology and Clinical Immunology Department, Spedali Civili and University of Brescia; F. Dall’Ara, MD, Rheumatology and Clinical Immunology Department, Spedali Civili and University of Brescia; M. Fredi, MD, Rheumatology and Clinical Immunology Department, Spedali Civili and University of Brescia; L. Andreoli, MD, PhD, Rheumatology and Clinical Immunology Department, Spedali Civili and University of Brescia; M. Gerosa, MD, PhD, Division of Rheumatology, Department of Clinical Sciences and Community Health, Ospedale Gaetano Pini, University of Milan; A. Hoxha, MD, PhD, Rheumatology Unit, Department of Medicine - DIMED, University of Padua; L. Massaro, MD, Internal Medicine and Medical Specialties Department, Policlinico Umberto I, La Sapienza University of Rome; M. Tonello, BSc, PhD, Rheumatology Unit, Department of Medicine - DIMED, University of Padua; N. Costedoat-Chalumeau, MD, PhD, AP-HP, Hôpital Cochin, Centre de référence maladies auto-immunes et systémiques rares, Service de Médecine Interne; P. Cacoub, MD, PhD, AP-HP, Hospital Pitié-Salpêtrière, Centre de référence maladies auto-immunes et systémiques rares, Service de Médecine Interne, Pierre et Marie Curie Paris VI University; F. Franceschini, MD, Rheumatology and Clinical Immunology Department, Spedali Civili and University of Brescia; P.L. Meroni, MD, Division of Rheumatology, Department of Clinical Sciences and Community Health, Ospedale Gaetano Pini, University of Milan; J.C. Piette, MD, PhD, AP-HP, Hospital Pitié-Salpêtrière, Centre de référence maladies auto-immunes et systémiques rares, Service de Médecine Interne, Pierre et Marie Curie Paris VI University; A. Ruffatti, MD, PhD, Rheumatology Unit, Department of Medicine - DIMED, University of Padua; G. Valesini, MD, Internal Medicine and Medical Specialties Department, Policlinico Umberto I, La Sapienza University of Rome; E.N. Harris, MPhil, MD, DM, Vice Chancellor Emeritus, University of the West Indies; A. Tincani, MD, Rheumatology and Clinical Immunology Department, Spedali Civili and University of Brescia. Drs. Taraborelli, Reggia, and Dall’Ara contributed equally to this paper. Address correspondence to Dr. A. Tincani, Rheumatology and Clinical Immunology Unit, Spedali Civili of Brescia, Piazzale Spedali Civili 1, 25123 Brescia, Italy. E-mail: angela.tincani@unibs.it. Accepted for publication April 12, 2017.
Maria Gerosa
From the Rheumatology and Clinical Immunology Department, Spedali Civili and University of Brescia, Brescia; Division of Rheumatology, Department of Clinical Sciences and Community Health, Ospedale Gaetano Pini, University of Milan, Milan; Rheumatology Unit, Department of Medicine - DIMED, University of Padua, Padua; Internal Medicine and Medical Specialties Department, Policlinico Umberto I, La Sapienza University of Rome, Rome, Italy; AP-HP, Hôpital Cochin, Centre de référence maladies auto-immunes et systémiques rares, Service de Médecine Interne; AP-HP, Hospital Pitié-Salpêtrière, Centre de référence maladies auto-immunes et systémiques rares, Service de Médecine Interne, Pierre et Marie Curie Paris VI University, Paris, France; University of the West Indies, Kingston, Jamaica. M. Taraborelli, MD, Rheumatology and Clinical Immunology Department, Spedali Civili and University of Brescia; R. Reggia, MD, Rheumatology and Clinical Immunology Department, Spedali Civili and University of Brescia; F. Dall’Ara, MD, Rheumatology and Clinical Immunology Department, Spedali Civili and University of Brescia; M. Fredi, MD, Rheumatology and Clinical Immunology Department, Spedali Civili and University of Brescia; L. Andreoli, MD, PhD, Rheumatology and Clinical Immunology Department, Spedali Civili and University of Brescia; M. Gerosa, MD, PhD, Division of Rheumatology, Department of Clinical Sciences and Community Health, Ospedale Gaetano Pini, University of Milan; A. Hoxha, MD, PhD, Rheumatology Unit, Department of Medicine - DIMED, University of Padua; L. Massaro, MD, Internal Medicine and Medical Specialties Department, Policlinico Umberto I, La Sapienza University of Rome; M. Tonello, BSc, PhD, Rheumatology Unit, Department of Medicine - DIMED, University of Padua; N. Costedoat-Chalumeau, MD, PhD, AP-HP, Hôpital Cochin, Centre de référence maladies auto-immunes et systémiques rares, Service de Médecine Interne; P. Cacoub, MD, PhD, AP-HP, Hospital Pitié-Salpêtrière, Centre de référence maladies auto-immunes et systémiques rares, Service de Médecine Interne, Pierre et Marie Curie Paris VI University; F. Franceschini, MD, Rheumatology and Clinical Immunology Department, Spedali Civili and University of Brescia; P.L. Meroni, MD, Division of Rheumatology, Department of Clinical Sciences and Community Health, Ospedale Gaetano Pini, University of Milan; J.C. Piette, MD, PhD, AP-HP, Hospital Pitié-Salpêtrière, Centre de référence maladies auto-immunes et systémiques rares, Service de Médecine Interne, Pierre et Marie Curie Paris VI University; A. Ruffatti, MD, PhD, Rheumatology Unit, Department of Medicine - DIMED, University of Padua; G. Valesini, MD, Internal Medicine and Medical Specialties Department, Policlinico Umberto I, La Sapienza University of Rome; E.N. Harris, MPhil, MD, DM, Vice Chancellor Emeritus, University of the West Indies; A. Tincani, MD, Rheumatology and Clinical Immunology Department, Spedali Civili and University of Brescia. Drs. Taraborelli, Reggia, and Dall’Ara contributed equally to this paper. Address correspondence to Dr. A. Tincani, Rheumatology and Clinical Immunology Unit, Spedali Civili of Brescia, Piazzale Spedali Civili 1, 25123 Brescia, Italy. E-mail: angela.tincani@unibs.it. Accepted for publication April 12, 2017.
Ariela Hoxha
From the Rheumatology and Clinical Immunology Department, Spedali Civili and University of Brescia, Brescia; Division of Rheumatology, Department of Clinical Sciences and Community Health, Ospedale Gaetano Pini, University of Milan, Milan; Rheumatology Unit, Department of Medicine - DIMED, University of Padua, Padua; Internal Medicine and Medical Specialties Department, Policlinico Umberto I, La Sapienza University of Rome, Rome, Italy; AP-HP, Hôpital Cochin, Centre de référence maladies auto-immunes et systémiques rares, Service de Médecine Interne; AP-HP, Hospital Pitié-Salpêtrière, Centre de référence maladies auto-immunes et systémiques rares, Service de Médecine Interne, Pierre et Marie Curie Paris VI University, Paris, France; University of the West Indies, Kingston, Jamaica. M. Taraborelli, MD, Rheumatology and Clinical Immunology Department, Spedali Civili and University of Brescia; R. Reggia, MD, Rheumatology and Clinical Immunology Department, Spedali Civili and University of Brescia; F. Dall’Ara, MD, Rheumatology and Clinical Immunology Department, Spedali Civili and University of Brescia; M. Fredi, MD, Rheumatology and Clinical Immunology Department, Spedali Civili and University of Brescia; L. Andreoli, MD, PhD, Rheumatology and Clinical Immunology Department, Spedali Civili and University of Brescia; M. Gerosa, MD, PhD, Division of Rheumatology, Department of Clinical Sciences and Community Health, Ospedale Gaetano Pini, University of Milan; A. Hoxha, MD, PhD, Rheumatology Unit, Department of Medicine - DIMED, University of Padua; L. Massaro, MD, Internal Medicine and Medical Specialties Department, Policlinico Umberto I, La Sapienza University of Rome; M. Tonello, BSc, PhD, Rheumatology Unit, Department of Medicine - DIMED, University of Padua; N. Costedoat-Chalumeau, MD, PhD, AP-HP, Hôpital Cochin, Centre de référence maladies auto-immunes et systémiques rares, Service de Médecine Interne; P. Cacoub, MD, PhD, AP-HP, Hospital Pitié-Salpêtrière, Centre de référence maladies auto-immunes et systémiques rares, Service de Médecine Interne, Pierre et Marie Curie Paris VI University; F. Franceschini, MD, Rheumatology and Clinical Immunology Department, Spedali Civili and University of Brescia; P.L. Meroni, MD, Division of Rheumatology, Department of Clinical Sciences and Community Health, Ospedale Gaetano Pini, University of Milan; J.C. Piette, MD, PhD, AP-HP, Hospital Pitié-Salpêtrière, Centre de référence maladies auto-immunes et systémiques rares, Service de Médecine Interne, Pierre et Marie Curie Paris VI University; A. Ruffatti, MD, PhD, Rheumatology Unit, Department of Medicine - DIMED, University of Padua; G. Valesini, MD, Internal Medicine and Medical Specialties Department, Policlinico Umberto I, La Sapienza University of Rome; E.N. Harris, MPhil, MD, DM, Vice Chancellor Emeritus, University of the West Indies; A. Tincani, MD, Rheumatology and Clinical Immunology Department, Spedali Civili and University of Brescia. Drs. Taraborelli, Reggia, and Dall’Ara contributed equally to this paper. Address correspondence to Dr. A. Tincani, Rheumatology and Clinical Immunology Unit, Spedali Civili of Brescia, Piazzale Spedali Civili 1, 25123 Brescia, Italy. E-mail: angela.tincani@unibs.it. Accepted for publication April 12, 2017.
Laura Massaro
From the Rheumatology and Clinical Immunology Department, Spedali Civili and University of Brescia, Brescia; Division of Rheumatology, Department of Clinical Sciences and Community Health, Ospedale Gaetano Pini, University of Milan, Milan; Rheumatology Unit, Department of Medicine - DIMED, University of Padua, Padua; Internal Medicine and Medical Specialties Department, Policlinico Umberto I, La Sapienza University of Rome, Rome, Italy; AP-HP, Hôpital Cochin, Centre de référence maladies auto-immunes et systémiques rares, Service de Médecine Interne; AP-HP, Hospital Pitié-Salpêtrière, Centre de référence maladies auto-immunes et systémiques rares, Service de Médecine Interne, Pierre et Marie Curie Paris VI University, Paris, France; University of the West Indies, Kingston, Jamaica. M. Taraborelli, MD, Rheumatology and Clinical Immunology Department, Spedali Civili and University of Brescia; R. Reggia, MD, Rheumatology and Clinical Immunology Department, Spedali Civili and University of Brescia; F. Dall’Ara, MD, Rheumatology and Clinical Immunology Department, Spedali Civili and University of Brescia; M. Fredi, MD, Rheumatology and Clinical Immunology Department, Spedali Civili and University of Brescia; L. Andreoli, MD, PhD, Rheumatology and Clinical Immunology Department, Spedali Civili and University of Brescia; M. Gerosa, MD, PhD, Division of Rheumatology, Department of Clinical Sciences and Community Health, Ospedale Gaetano Pini, University of Milan; A. Hoxha, MD, PhD, Rheumatology Unit, Department of Medicine - DIMED, University of Padua; L. Massaro, MD, Internal Medicine and Medical Specialties Department, Policlinico Umberto I, La Sapienza University of Rome; M. Tonello, BSc, PhD, Rheumatology Unit, Department of Medicine - DIMED, University of Padua; N. Costedoat-Chalumeau, MD, PhD, AP-HP, Hôpital Cochin, Centre de référence maladies auto-immunes et systémiques rares, Service de Médecine Interne; P. Cacoub, MD, PhD, AP-HP, Hospital Pitié-Salpêtrière, Centre de référence maladies auto-immunes et systémiques rares, Service de Médecine Interne, Pierre et Marie Curie Paris VI University; F. Franceschini, MD, Rheumatology and Clinical Immunology Department, Spedali Civili and University of Brescia; P.L. Meroni, MD, Division of Rheumatology, Department of Clinical Sciences and Community Health, Ospedale Gaetano Pini, University of Milan; J.C. Piette, MD, PhD, AP-HP, Hospital Pitié-Salpêtrière, Centre de référence maladies auto-immunes et systémiques rares, Service de Médecine Interne, Pierre et Marie Curie Paris VI University; A. Ruffatti, MD, PhD, Rheumatology Unit, Department of Medicine - DIMED, University of Padua; G. Valesini, MD, Internal Medicine and Medical Specialties Department, Policlinico Umberto I, La Sapienza University of Rome; E.N. Harris, MPhil, MD, DM, Vice Chancellor Emeritus, University of the West Indies; A. Tincani, MD, Rheumatology and Clinical Immunology Department, Spedali Civili and University of Brescia. Drs. Taraborelli, Reggia, and Dall’Ara contributed equally to this paper. Address correspondence to Dr. A. Tincani, Rheumatology and Clinical Immunology Unit, Spedali Civili of Brescia, Piazzale Spedali Civili 1, 25123 Brescia, Italy. E-mail: angela.tincani@unibs.it. Accepted for publication April 12, 2017.
Marta Tonello
From the Rheumatology and Clinical Immunology Department, Spedali Civili and University of Brescia, Brescia; Division of Rheumatology, Department of Clinical Sciences and Community Health, Ospedale Gaetano Pini, University of Milan, Milan; Rheumatology Unit, Department of Medicine - DIMED, University of Padua, Padua; Internal Medicine and Medical Specialties Department, Policlinico Umberto I, La Sapienza University of Rome, Rome, Italy; AP-HP, Hôpital Cochin, Centre de référence maladies auto-immunes et systémiques rares, Service de Médecine Interne; AP-HP, Hospital Pitié-Salpêtrière, Centre de référence maladies auto-immunes et systémiques rares, Service de Médecine Interne, Pierre et Marie Curie Paris VI University, Paris, France; University of the West Indies, Kingston, Jamaica. M. Taraborelli, MD, Rheumatology and Clinical Immunology Department, Spedali Civili and University of Brescia; R. Reggia, MD, Rheumatology and Clinical Immunology Department, Spedali Civili and University of Brescia; F. Dall’Ara, MD, Rheumatology and Clinical Immunology Department, Spedali Civili and University of Brescia; M. Fredi, MD, Rheumatology and Clinical Immunology Department, Spedali Civili and University of Brescia; L. Andreoli, MD, PhD, Rheumatology and Clinical Immunology Department, Spedali Civili and University of Brescia; M. Gerosa, MD, PhD, Division of Rheumatology, Department of Clinical Sciences and Community Health, Ospedale Gaetano Pini, University of Milan; A. Hoxha, MD, PhD, Rheumatology Unit, Department of Medicine - DIMED, University of Padua; L. Massaro, MD, Internal Medicine and Medical Specialties Department, Policlinico Umberto I, La Sapienza University of Rome; M. Tonello, BSc, PhD, Rheumatology Unit, Department of Medicine - DIMED, University of Padua; N. Costedoat-Chalumeau, MD, PhD, AP-HP, Hôpital Cochin, Centre de référence maladies auto-immunes et systémiques rares, Service de Médecine Interne; P. Cacoub, MD, PhD, AP-HP, Hospital Pitié-Salpêtrière, Centre de référence maladies auto-immunes et systémiques rares, Service de Médecine Interne, Pierre et Marie Curie Paris VI University; F. Franceschini, MD, Rheumatology and Clinical Immunology Department, Spedali Civili and University of Brescia; P.L. Meroni, MD, Division of Rheumatology, Department of Clinical Sciences and Community Health, Ospedale Gaetano Pini, University of Milan; J.C. Piette, MD, PhD, AP-HP, Hospital Pitié-Salpêtrière, Centre de référence maladies auto-immunes et systémiques rares, Service de Médecine Interne, Pierre et Marie Curie Paris VI University; A. Ruffatti, MD, PhD, Rheumatology Unit, Department of Medicine - DIMED, University of Padua; G. Valesini, MD, Internal Medicine and Medical Specialties Department, Policlinico Umberto I, La Sapienza University of Rome; E.N. Harris, MPhil, MD, DM, Vice Chancellor Emeritus, University of the West Indies; A. Tincani, MD, Rheumatology and Clinical Immunology Department, Spedali Civili and University of Brescia. Drs. Taraborelli, Reggia, and Dall’Ara contributed equally to this paper. Address correspondence to Dr. A. Tincani, Rheumatology and Clinical Immunology Unit, Spedali Civili of Brescia, Piazzale Spedali Civili 1, 25123 Brescia, Italy. E-mail: angela.tincani@unibs.it. Accepted for publication April 12, 2017.
Nathalie Costedoat-Chalumeau
From the Rheumatology and Clinical Immunology Department, Spedali Civili and University of Brescia, Brescia; Division of Rheumatology, Department of Clinical Sciences and Community Health, Ospedale Gaetano Pini, University of Milan, Milan; Rheumatology Unit, Department of Medicine - DIMED, University of Padua, Padua; Internal Medicine and Medical Specialties Department, Policlinico Umberto I, La Sapienza University of Rome, Rome, Italy; AP-HP, Hôpital Cochin, Centre de référence maladies auto-immunes et systémiques rares, Service de Médecine Interne; AP-HP, Hospital Pitié-Salpêtrière, Centre de référence maladies auto-immunes et systémiques rares, Service de Médecine Interne, Pierre et Marie Curie Paris VI University, Paris, France; University of the West Indies, Kingston, Jamaica. M. Taraborelli, MD, Rheumatology and Clinical Immunology Department, Spedali Civili and University of Brescia; R. Reggia, MD, Rheumatology and Clinical Immunology Department, Spedali Civili and University of Brescia; F. Dall’Ara, MD, Rheumatology and Clinical Immunology Department, Spedali Civili and University of Brescia; M. Fredi, MD, Rheumatology and Clinical Immunology Department, Spedali Civili and University of Brescia; L. Andreoli, MD, PhD, Rheumatology and Clinical Immunology Department, Spedali Civili and University of Brescia; M. Gerosa, MD, PhD, Division of Rheumatology, Department of Clinical Sciences and Community Health, Ospedale Gaetano Pini, University of Milan; A. Hoxha, MD, PhD, Rheumatology Unit, Department of Medicine - DIMED, University of Padua; L. Massaro, MD, Internal Medicine and Medical Specialties Department, Policlinico Umberto I, La Sapienza University of Rome; M. Tonello, BSc, PhD, Rheumatology Unit, Department of Medicine - DIMED, University of Padua; N. Costedoat-Chalumeau, MD, PhD, AP-HP, Hôpital Cochin, Centre de référence maladies auto-immunes et systémiques rares, Service de Médecine Interne; P. Cacoub, MD, PhD, AP-HP, Hospital Pitié-Salpêtrière, Centre de référence maladies auto-immunes et systémiques rares, Service de Médecine Interne, Pierre et Marie Curie Paris VI University; F. Franceschini, MD, Rheumatology and Clinical Immunology Department, Spedali Civili and University of Brescia; P.L. Meroni, MD, Division of Rheumatology, Department of Clinical Sciences and Community Health, Ospedale Gaetano Pini, University of Milan; J.C. Piette, MD, PhD, AP-HP, Hospital Pitié-Salpêtrière, Centre de référence maladies auto-immunes et systémiques rares, Service de Médecine Interne, Pierre et Marie Curie Paris VI University; A. Ruffatti, MD, PhD, Rheumatology Unit, Department of Medicine - DIMED, University of Padua; G. Valesini, MD, Internal Medicine and Medical Specialties Department, Policlinico Umberto I, La Sapienza University of Rome; E.N. Harris, MPhil, MD, DM, Vice Chancellor Emeritus, University of the West Indies; A. Tincani, MD, Rheumatology and Clinical Immunology Department, Spedali Civili and University of Brescia. Drs. Taraborelli, Reggia, and Dall’Ara contributed equally to this paper. Address correspondence to Dr. A. Tincani, Rheumatology and Clinical Immunology Unit, Spedali Civili of Brescia, Piazzale Spedali Civili 1, 25123 Brescia, Italy. E-mail: angela.tincani@unibs.it. Accepted for publication April 12, 2017.
Patrice Cacoub
From the Rheumatology and Clinical Immunology Department, Spedali Civili and University of Brescia, Brescia; Division of Rheumatology, Department of Clinical Sciences and Community Health, Ospedale Gaetano Pini, University of Milan, Milan; Rheumatology Unit, Department of Medicine - DIMED, University of Padua, Padua; Internal Medicine and Medical Specialties Department, Policlinico Umberto I, La Sapienza University of Rome, Rome, Italy; AP-HP, Hôpital Cochin, Centre de référence maladies auto-immunes et systémiques rares, Service de Médecine Interne; AP-HP, Hospital Pitié-Salpêtrière, Centre de référence maladies auto-immunes et systémiques rares, Service de Médecine Interne, Pierre et Marie Curie Paris VI University, Paris, France; University of the West Indies, Kingston, Jamaica. M. Taraborelli, MD, Rheumatology and Clinical Immunology Department, Spedali Civili and University of Brescia; R. Reggia, MD, Rheumatology and Clinical Immunology Department, Spedali Civili and University of Brescia; F. Dall’Ara, MD, Rheumatology and Clinical Immunology Department, Spedali Civili and University of Brescia; M. Fredi, MD, Rheumatology and Clinical Immunology Department, Spedali Civili and University of Brescia; L. Andreoli, MD, PhD, Rheumatology and Clinical Immunology Department, Spedali Civili and University of Brescia; M. Gerosa, MD, PhD, Division of Rheumatology, Department of Clinical Sciences and Community Health, Ospedale Gaetano Pini, University of Milan; A. Hoxha, MD, PhD, Rheumatology Unit, Department of Medicine - DIMED, University of Padua; L. Massaro, MD, Internal Medicine and Medical Specialties Department, Policlinico Umberto I, La Sapienza University of Rome; M. Tonello, BSc, PhD, Rheumatology Unit, Department of Medicine - DIMED, University of Padua; N. Costedoat-Chalumeau, MD, PhD, AP-HP, Hôpital Cochin, Centre de référence maladies auto-immunes et systémiques rares, Service de Médecine Interne; P. Cacoub, MD, PhD, AP-HP, Hospital Pitié-Salpêtrière, Centre de référence maladies auto-immunes et systémiques rares, Service de Médecine Interne, Pierre et Marie Curie Paris VI University; F. Franceschini, MD, Rheumatology and Clinical Immunology Department, Spedali Civili and University of Brescia; P.L. Meroni, MD, Division of Rheumatology, Department of Clinical Sciences and Community Health, Ospedale Gaetano Pini, University of Milan; J.C. Piette, MD, PhD, AP-HP, Hospital Pitié-Salpêtrière, Centre de référence maladies auto-immunes et systémiques rares, Service de Médecine Interne, Pierre et Marie Curie Paris VI University; A. Ruffatti, MD, PhD, Rheumatology Unit, Department of Medicine - DIMED, University of Padua; G. Valesini, MD, Internal Medicine and Medical Specialties Department, Policlinico Umberto I, La Sapienza University of Rome; E.N. Harris, MPhil, MD, DM, Vice Chancellor Emeritus, University of the West Indies; A. Tincani, MD, Rheumatology and Clinical Immunology Department, Spedali Civili and University of Brescia. Drs. Taraborelli, Reggia, and Dall’Ara contributed equally to this paper. Address correspondence to Dr. A. Tincani, Rheumatology and Clinical Immunology Unit, Spedali Civili of Brescia, Piazzale Spedali Civili 1, 25123 Brescia, Italy. E-mail: angela.tincani@unibs.it. Accepted for publication April 12, 2017.
Franco Franceschini
From the Rheumatology and Clinical Immunology Department, Spedali Civili and University of Brescia, Brescia; Division of Rheumatology, Department of Clinical Sciences and Community Health, Ospedale Gaetano Pini, University of Milan, Milan; Rheumatology Unit, Department of Medicine - DIMED, University of Padua, Padua; Internal Medicine and Medical Specialties Department, Policlinico Umberto I, La Sapienza University of Rome, Rome, Italy; AP-HP, Hôpital Cochin, Centre de référence maladies auto-immunes et systémiques rares, Service de Médecine Interne; AP-HP, Hospital Pitié-Salpêtrière, Centre de référence maladies auto-immunes et systémiques rares, Service de Médecine Interne, Pierre et Marie Curie Paris VI University, Paris, France; University of the West Indies, Kingston, Jamaica. M. Taraborelli, MD, Rheumatology and Clinical Immunology Department, Spedali Civili and University of Brescia; R. Reggia, MD, Rheumatology and Clinical Immunology Department, Spedali Civili and University of Brescia; F. Dall’Ara, MD, Rheumatology and Clinical Immunology Department, Spedali Civili and University of Brescia; M. Fredi, MD, Rheumatology and Clinical Immunology Department, Spedali Civili and University of Brescia; L. Andreoli, MD, PhD, Rheumatology and Clinical Immunology Department, Spedali Civili and University of Brescia; M. Gerosa, MD, PhD, Division of Rheumatology, Department of Clinical Sciences and Community Health, Ospedale Gaetano Pini, University of Milan; A. Hoxha, MD, PhD, Rheumatology Unit, Department of Medicine - DIMED, University of Padua; L. Massaro, MD, Internal Medicine and Medical Specialties Department, Policlinico Umberto I, La Sapienza University of Rome; M. Tonello, BSc, PhD, Rheumatology Unit, Department of Medicine - DIMED, University of Padua; N. Costedoat-Chalumeau, MD, PhD, AP-HP, Hôpital Cochin, Centre de référence maladies auto-immunes et systémiques rares, Service de Médecine Interne; P. Cacoub, MD, PhD, AP-HP, Hospital Pitié-Salpêtrière, Centre de référence maladies auto-immunes et systémiques rares, Service de Médecine Interne, Pierre et Marie Curie Paris VI University; F. Franceschini, MD, Rheumatology and Clinical Immunology Department, Spedali Civili and University of Brescia; P.L. Meroni, MD, Division of Rheumatology, Department of Clinical Sciences and Community Health, Ospedale Gaetano Pini, University of Milan; J.C. Piette, MD, PhD, AP-HP, Hospital Pitié-Salpêtrière, Centre de référence maladies auto-immunes et systémiques rares, Service de Médecine Interne, Pierre et Marie Curie Paris VI University; A. Ruffatti, MD, PhD, Rheumatology Unit, Department of Medicine - DIMED, University of Padua; G. Valesini, MD, Internal Medicine and Medical Specialties Department, Policlinico Umberto I, La Sapienza University of Rome; E.N. Harris, MPhil, MD, DM, Vice Chancellor Emeritus, University of the West Indies; A. Tincani, MD, Rheumatology and Clinical Immunology Department, Spedali Civili and University of Brescia. Drs. Taraborelli, Reggia, and Dall’Ara contributed equally to this paper. Address correspondence to Dr. A. Tincani, Rheumatology and Clinical Immunology Unit, Spedali Civili of Brescia, Piazzale Spedali Civili 1, 25123 Brescia, Italy. E-mail: angela.tincani@unibs.it. Accepted for publication April 12, 2017.
Pier Luigi Meroni
From the Rheumatology and Clinical Immunology Department, Spedali Civili and University of Brescia, Brescia; Division of Rheumatology, Department of Clinical Sciences and Community Health, Ospedale Gaetano Pini, University of Milan, Milan; Rheumatology Unit, Department of Medicine - DIMED, University of Padua, Padua; Internal Medicine and Medical Specialties Department, Policlinico Umberto I, La Sapienza University of Rome, Rome, Italy; AP-HP, Hôpital Cochin, Centre de référence maladies auto-immunes et systémiques rares, Service de Médecine Interne; AP-HP, Hospital Pitié-Salpêtrière, Centre de référence maladies auto-immunes et systémiques rares, Service de Médecine Interne, Pierre et Marie Curie Paris VI University, Paris, France; University of the West Indies, Kingston, Jamaica. M. Taraborelli, MD, Rheumatology and Clinical Immunology Department, Spedali Civili and University of Brescia; R. Reggia, MD, Rheumatology and Clinical Immunology Department, Spedali Civili and University of Brescia; F. Dall’Ara, MD, Rheumatology and Clinical Immunology Department, Spedali Civili and University of Brescia; M. Fredi, MD, Rheumatology and Clinical Immunology Department, Spedali Civili and University of Brescia; L. Andreoli, MD, PhD, Rheumatology and Clinical Immunology Department, Spedali Civili and University of Brescia; M. Gerosa, MD, PhD, Division of Rheumatology, Department of Clinical Sciences and Community Health, Ospedale Gaetano Pini, University of Milan; A. Hoxha, MD, PhD, Rheumatology Unit, Department of Medicine - DIMED, University of Padua; L. Massaro, MD, Internal Medicine and Medical Specialties Department, Policlinico Umberto I, La Sapienza University of Rome; M. Tonello, BSc, PhD, Rheumatology Unit, Department of Medicine - DIMED, University of Padua; N. Costedoat-Chalumeau, MD, PhD, AP-HP, Hôpital Cochin, Centre de référence maladies auto-immunes et systémiques rares, Service de Médecine Interne; P. Cacoub, MD, PhD, AP-HP, Hospital Pitié-Salpêtrière, Centre de référence maladies auto-immunes et systémiques rares, Service de Médecine Interne, Pierre et Marie Curie Paris VI University; F. Franceschini, MD, Rheumatology and Clinical Immunology Department, Spedali Civili and University of Brescia; P.L. Meroni, MD, Division of Rheumatology, Department of Clinical Sciences and Community Health, Ospedale Gaetano Pini, University of Milan; J.C. Piette, MD, PhD, AP-HP, Hospital Pitié-Salpêtrière, Centre de référence maladies auto-immunes et systémiques rares, Service de Médecine Interne, Pierre et Marie Curie Paris VI University; A. Ruffatti, MD, PhD, Rheumatology Unit, Department of Medicine - DIMED, University of Padua; G. Valesini, MD, Internal Medicine and Medical Specialties Department, Policlinico Umberto I, La Sapienza University of Rome; E.N. Harris, MPhil, MD, DM, Vice Chancellor Emeritus, University of the West Indies; A. Tincani, MD, Rheumatology and Clinical Immunology Department, Spedali Civili and University of Brescia. Drs. Taraborelli, Reggia, and Dall’Ara contributed equally to this paper. Address correspondence to Dr. A. Tincani, Rheumatology and Clinical Immunology Unit, Spedali Civili of Brescia, Piazzale Spedali Civili 1, 25123 Brescia, Italy. E-mail: angela.tincani@unibs.it. Accepted for publication April 12, 2017.
Jean Charles Piette
From the Rheumatology and Clinical Immunology Department, Spedali Civili and University of Brescia, Brescia; Division of Rheumatology, Department of Clinical Sciences and Community Health, Ospedale Gaetano Pini, University of Milan, Milan; Rheumatology Unit, Department of Medicine - DIMED, University of Padua, Padua; Internal Medicine and Medical Specialties Department, Policlinico Umberto I, La Sapienza University of Rome, Rome, Italy; AP-HP, Hôpital Cochin, Centre de référence maladies auto-immunes et systémiques rares, Service de Médecine Interne; AP-HP, Hospital Pitié-Salpêtrière, Centre de référence maladies auto-immunes et systémiques rares, Service de Médecine Interne, Pierre et Marie Curie Paris VI University, Paris, France; University of the West Indies, Kingston, Jamaica. M. Taraborelli, MD, Rheumatology and Clinical Immunology Department, Spedali Civili and University of Brescia; R. Reggia, MD, Rheumatology and Clinical Immunology Department, Spedali Civili and University of Brescia; F. Dall’Ara, MD, Rheumatology and Clinical Immunology Department, Spedali Civili and University of Brescia; M. Fredi, MD, Rheumatology and Clinical Immunology Department, Spedali Civili and University of Brescia; L. Andreoli, MD, PhD, Rheumatology and Clinical Immunology Department, Spedali Civili and University of Brescia; M. Gerosa, MD, PhD, Division of Rheumatology, Department of Clinical Sciences and Community Health, Ospedale Gaetano Pini, University of Milan; A. Hoxha, MD, PhD, Rheumatology Unit, Department of Medicine - DIMED, University of Padua; L. Massaro, MD, Internal Medicine and Medical Specialties Department, Policlinico Umberto I, La Sapienza University of Rome; M. Tonello, BSc, PhD, Rheumatology Unit, Department of Medicine - DIMED, University of Padua; N. Costedoat-Chalumeau, MD, PhD, AP-HP, Hôpital Cochin, Centre de référence maladies auto-immunes et systémiques rares, Service de Médecine Interne; P. Cacoub, MD, PhD, AP-HP, Hospital Pitié-Salpêtrière, Centre de référence maladies auto-immunes et systémiques rares, Service de Médecine Interne, Pierre et Marie Curie Paris VI University; F. Franceschini, MD, Rheumatology and Clinical Immunology Department, Spedali Civili and University of Brescia; P.L. Meroni, MD, Division of Rheumatology, Department of Clinical Sciences and Community Health, Ospedale Gaetano Pini, University of Milan; J.C. Piette, MD, PhD, AP-HP, Hospital Pitié-Salpêtrière, Centre de référence maladies auto-immunes et systémiques rares, Service de Médecine Interne, Pierre et Marie Curie Paris VI University; A. Ruffatti, MD, PhD, Rheumatology Unit, Department of Medicine - DIMED, University of Padua; G. Valesini, MD, Internal Medicine and Medical Specialties Department, Policlinico Umberto I, La Sapienza University of Rome; E.N. Harris, MPhil, MD, DM, Vice Chancellor Emeritus, University of the West Indies; A. Tincani, MD, Rheumatology and Clinical Immunology Department, Spedali Civili and University of Brescia. Drs. Taraborelli, Reggia, and Dall’Ara contributed equally to this paper. Address correspondence to Dr. A. Tincani, Rheumatology and Clinical Immunology Unit, Spedali Civili of Brescia, Piazzale Spedali Civili 1, 25123 Brescia, Italy. E-mail: angela.tincani@unibs.it. Accepted for publication April 12, 2017.
Amelia Ruffatti
From the Rheumatology and Clinical Immunology Department, Spedali Civili and University of Brescia, Brescia; Division of Rheumatology, Department of Clinical Sciences and Community Health, Ospedale Gaetano Pini, University of Milan, Milan; Rheumatology Unit, Department of Medicine - DIMED, University of Padua, Padua; Internal Medicine and Medical Specialties Department, Policlinico Umberto I, La Sapienza University of Rome, Rome, Italy; AP-HP, Hôpital Cochin, Centre de référence maladies auto-immunes et systémiques rares, Service de Médecine Interne; AP-HP, Hospital Pitié-Salpêtrière, Centre de référence maladies auto-immunes et systémiques rares, Service de Médecine Interne, Pierre et Marie Curie Paris VI University, Paris, France; University of the West Indies, Kingston, Jamaica. M. Taraborelli, MD, Rheumatology and Clinical Immunology Department, Spedali Civili and University of Brescia; R. Reggia, MD, Rheumatology and Clinical Immunology Department, Spedali Civili and University of Brescia; F. Dall’Ara, MD, Rheumatology and Clinical Immunology Department, Spedali Civili and University of Brescia; M. Fredi, MD, Rheumatology and Clinical Immunology Department, Spedali Civili and University of Brescia; L. Andreoli, MD, PhD, Rheumatology and Clinical Immunology Department, Spedali Civili and University of Brescia; M. Gerosa, MD, PhD, Division of Rheumatology, Department of Clinical Sciences and Community Health, Ospedale Gaetano Pini, University of Milan; A. Hoxha, MD, PhD, Rheumatology Unit, Department of Medicine - DIMED, University of Padua; L. Massaro, MD, Internal Medicine and Medical Specialties Department, Policlinico Umberto I, La Sapienza University of Rome; M. Tonello, BSc, PhD, Rheumatology Unit, Department of Medicine - DIMED, University of Padua; N. Costedoat-Chalumeau, MD, PhD, AP-HP, Hôpital Cochin, Centre de référence maladies auto-immunes et systémiques rares, Service de Médecine Interne; P. Cacoub, MD, PhD, AP-HP, Hospital Pitié-Salpêtrière, Centre de référence maladies auto-immunes et systémiques rares, Service de Médecine Interne, Pierre et Marie Curie Paris VI University; F. Franceschini, MD, Rheumatology and Clinical Immunology Department, Spedali Civili and University of Brescia; P.L. Meroni, MD, Division of Rheumatology, Department of Clinical Sciences and Community Health, Ospedale Gaetano Pini, University of Milan; J.C. Piette, MD, PhD, AP-HP, Hospital Pitié-Salpêtrière, Centre de référence maladies auto-immunes et systémiques rares, Service de Médecine Interne, Pierre et Marie Curie Paris VI University; A. Ruffatti, MD, PhD, Rheumatology Unit, Department of Medicine - DIMED, University of Padua; G. Valesini, MD, Internal Medicine and Medical Specialties Department, Policlinico Umberto I, La Sapienza University of Rome; E.N. Harris, MPhil, MD, DM, Vice Chancellor Emeritus, University of the West Indies; A. Tincani, MD, Rheumatology and Clinical Immunology Department, Spedali Civili and University of Brescia. Drs. Taraborelli, Reggia, and Dall’Ara contributed equally to this paper. Address correspondence to Dr. A. Tincani, Rheumatology and Clinical Immunology Unit, Spedali Civili of Brescia, Piazzale Spedali Civili 1, 25123 Brescia, Italy. E-mail: angela.tincani@unibs.it. Accepted for publication April 12, 2017.
Guido Valesini
From the Rheumatology and Clinical Immunology Department, Spedali Civili and University of Brescia, Brescia; Division of Rheumatology, Department of Clinical Sciences and Community Health, Ospedale Gaetano Pini, University of Milan, Milan; Rheumatology Unit, Department of Medicine - DIMED, University of Padua, Padua; Internal Medicine and Medical Specialties Department, Policlinico Umberto I, La Sapienza University of Rome, Rome, Italy; AP-HP, Hôpital Cochin, Centre de référence maladies auto-immunes et systémiques rares, Service de Médecine Interne; AP-HP, Hospital Pitié-Salpêtrière, Centre de référence maladies auto-immunes et systémiques rares, Service de Médecine Interne, Pierre et Marie Curie Paris VI University, Paris, France; University of the West Indies, Kingston, Jamaica. M. Taraborelli, MD, Rheumatology and Clinical Immunology Department, Spedali Civili and University of Brescia; R. Reggia, MD, Rheumatology and Clinical Immunology Department, Spedali Civili and University of Brescia; F. Dall’Ara, MD, Rheumatology and Clinical Immunology Department, Spedali Civili and University of Brescia; M. Fredi, MD, Rheumatology and Clinical Immunology Department, Spedali Civili and University of Brescia; L. Andreoli, MD, PhD, Rheumatology and Clinical Immunology Department, Spedali Civili and University of Brescia; M. Gerosa, MD, PhD, Division of Rheumatology, Department of Clinical Sciences and Community Health, Ospedale Gaetano Pini, University of Milan; A. Hoxha, MD, PhD, Rheumatology Unit, Department of Medicine - DIMED, University of Padua; L. Massaro, MD, Internal Medicine and Medical Specialties Department, Policlinico Umberto I, La Sapienza University of Rome; M. Tonello, BSc, PhD, Rheumatology Unit, Department of Medicine - DIMED, University of Padua; N. Costedoat-Chalumeau, MD, PhD, AP-HP, Hôpital Cochin, Centre de référence maladies auto-immunes et systémiques rares, Service de Médecine Interne; P. Cacoub, MD, PhD, AP-HP, Hospital Pitié-Salpêtrière, Centre de référence maladies auto-immunes et systémiques rares, Service de Médecine Interne, Pierre et Marie Curie Paris VI University; F. Franceschini, MD, Rheumatology and Clinical Immunology Department, Spedali Civili and University of Brescia; P.L. Meroni, MD, Division of Rheumatology, Department of Clinical Sciences and Community Health, Ospedale Gaetano Pini, University of Milan; J.C. Piette, MD, PhD, AP-HP, Hospital Pitié-Salpêtrière, Centre de référence maladies auto-immunes et systémiques rares, Service de Médecine Interne, Pierre et Marie Curie Paris VI University; A. Ruffatti, MD, PhD, Rheumatology Unit, Department of Medicine - DIMED, University of Padua; G. Valesini, MD, Internal Medicine and Medical Specialties Department, Policlinico Umberto I, La Sapienza University of Rome; E.N. Harris, MPhil, MD, DM, Vice Chancellor Emeritus, University of the West Indies; A. Tincani, MD, Rheumatology and Clinical Immunology Department, Spedali Civili and University of Brescia. Drs. Taraborelli, Reggia, and Dall’Ara contributed equally to this paper. Address correspondence to Dr. A. Tincani, Rheumatology and Clinical Immunology Unit, Spedali Civili of Brescia, Piazzale Spedali Civili 1, 25123 Brescia, Italy. E-mail: angela.tincani@unibs.it. Accepted for publication April 12, 2017.
Eon Nigel Harris
From the Rheumatology and Clinical Immunology Department, Spedali Civili and University of Brescia, Brescia; Division of Rheumatology, Department of Clinical Sciences and Community Health, Ospedale Gaetano Pini, University of Milan, Milan; Rheumatology Unit, Department of Medicine - DIMED, University of Padua, Padua; Internal Medicine and Medical Specialties Department, Policlinico Umberto I, La Sapienza University of Rome, Rome, Italy; AP-HP, Hôpital Cochin, Centre de référence maladies auto-immunes et systémiques rares, Service de Médecine Interne; AP-HP, Hospital Pitié-Salpêtrière, Centre de référence maladies auto-immunes et systémiques rares, Service de Médecine Interne, Pierre et Marie Curie Paris VI University, Paris, France; University of the West Indies, Kingston, Jamaica. M. Taraborelli, MD, Rheumatology and Clinical Immunology Department, Spedali Civili and University of Brescia; R. Reggia, MD, Rheumatology and Clinical Immunology Department, Spedali Civili and University of Brescia; F. Dall’Ara, MD, Rheumatology and Clinical Immunology Department, Spedali Civili and University of Brescia; M. Fredi, MD, Rheumatology and Clinical Immunology Department, Spedali Civili and University of Brescia; L. Andreoli, MD, PhD, Rheumatology and Clinical Immunology Department, Spedali Civili and University of Brescia; M. Gerosa, MD, PhD, Division of Rheumatology, Department of Clinical Sciences and Community Health, Ospedale Gaetano Pini, University of Milan; A. Hoxha, MD, PhD, Rheumatology Unit, Department of Medicine - DIMED, University of Padua; L. Massaro, MD, Internal Medicine and Medical Specialties Department, Policlinico Umberto I, La Sapienza University of Rome; M. Tonello, BSc, PhD, Rheumatology Unit, Department of Medicine - DIMED, University of Padua; N. Costedoat-Chalumeau, MD, PhD, AP-HP, Hôpital Cochin, Centre de référence maladies auto-immunes et systémiques rares, Service de Médecine Interne; P. Cacoub, MD, PhD, AP-HP, Hospital Pitié-Salpêtrière, Centre de référence maladies auto-immunes et systémiques rares, Service de Médecine Interne, Pierre et Marie Curie Paris VI University; F. Franceschini, MD, Rheumatology and Clinical Immunology Department, Spedali Civili and University of Brescia; P.L. Meroni, MD, Division of Rheumatology, Department of Clinical Sciences and Community Health, Ospedale Gaetano Pini, University of Milan; J.C. Piette, MD, PhD, AP-HP, Hospital Pitié-Salpêtrière, Centre de référence maladies auto-immunes et systémiques rares, Service de Médecine Interne, Pierre et Marie Curie Paris VI University; A. Ruffatti, MD, PhD, Rheumatology Unit, Department of Medicine - DIMED, University of Padua; G. Valesini, MD, Internal Medicine and Medical Specialties Department, Policlinico Umberto I, La Sapienza University of Rome; E.N. Harris, MPhil, MD, DM, Vice Chancellor Emeritus, University of the West Indies; A. Tincani, MD, Rheumatology and Clinical Immunology Department, Spedali Civili and University of Brescia. Drs. Taraborelli, Reggia, and Dall’Ara contributed equally to this paper. Address correspondence to Dr. A. Tincani, Rheumatology and Clinical Immunology Unit, Spedali Civili of Brescia, Piazzale Spedali Civili 1, 25123 Brescia, Italy. E-mail: angela.tincani@unibs.it. Accepted for publication April 12, 2017.
Angela Tincani
From the Rheumatology and Clinical Immunology Department, Spedali Civili and University of Brescia, Brescia; Division of Rheumatology, Department of Clinical Sciences and Community Health, Ospedale Gaetano Pini, University of Milan, Milan; Rheumatology Unit, Department of Medicine - DIMED, University of Padua, Padua; Internal Medicine and Medical Specialties Department, Policlinico Umberto I, La Sapienza University of Rome, Rome, Italy; AP-HP, Hôpital Cochin, Centre de référence maladies auto-immunes et systémiques rares, Service de Médecine Interne; AP-HP, Hospital Pitié-Salpêtrière, Centre de référence maladies auto-immunes et systémiques rares, Service de Médecine Interne, Pierre et Marie Curie Paris VI University, Paris, France; University of the West Indies, Kingston, Jamaica. M. Taraborelli, MD, Rheumatology and Clinical Immunology Department, Spedali Civili and University of Brescia; R. Reggia, MD, Rheumatology and Clinical Immunology Department, Spedali Civili and University of Brescia; F. Dall’Ara, MD, Rheumatology and Clinical Immunology Department, Spedali Civili and University of Brescia; M. Fredi, MD, Rheumatology and Clinical Immunology Department, Spedali Civili and University of Brescia; L. Andreoli, MD, PhD, Rheumatology and Clinical Immunology Department, Spedali Civili and University of Brescia; M. Gerosa, MD, PhD, Division of Rheumatology, Department of Clinical Sciences and Community Health, Ospedale Gaetano Pini, University of Milan; A. Hoxha, MD, PhD, Rheumatology Unit, Department of Medicine - DIMED, University of Padua; L. Massaro, MD, Internal Medicine and Medical Specialties Department, Policlinico Umberto I, La Sapienza University of Rome; M. Tonello, BSc, PhD, Rheumatology Unit, Department of Medicine - DIMED, University of Padua; N. Costedoat-Chalumeau, MD, PhD, AP-HP, Hôpital Cochin, Centre de référence maladies auto-immunes et systémiques rares, Service de Médecine Interne; P. Cacoub, MD, PhD, AP-HP, Hospital Pitié-Salpêtrière, Centre de référence maladies auto-immunes et systémiques rares, Service de Médecine Interne, Pierre et Marie Curie Paris VI University; F. Franceschini, MD, Rheumatology and Clinical Immunology Department, Spedali Civili and University of Brescia; P.L. Meroni, MD, Division of Rheumatology, Department of Clinical Sciences and Community Health, Ospedale Gaetano Pini, University of Milan; J.C. Piette, MD, PhD, AP-HP, Hospital Pitié-Salpêtrière, Centre de référence maladies auto-immunes et systémiques rares, Service de Médecine Interne, Pierre et Marie Curie Paris VI University; A. Ruffatti, MD, PhD, Rheumatology Unit, Department of Medicine - DIMED, University of Padua; G. Valesini, MD, Internal Medicine and Medical Specialties Department, Policlinico Umberto I, La Sapienza University of Rome; E.N. Harris, MPhil, MD, DM, Vice Chancellor Emeritus, University of the West Indies; A. Tincani, MD, Rheumatology and Clinical Immunology Department, Spedali Civili and University of Brescia. Drs. Taraborelli, Reggia, and Dall’Ara contributed equally to this paper. Address correspondence to Dr. A. Tincani, Rheumatology and Clinical Immunology Unit, Spedali Civili of Brescia, Piazzale Spedali Civili 1, 25123 Brescia, Italy. E-mail: angela.tincani@unibs.it. Accepted for publication April 12, 2017.
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- Published online June 1, 2017.
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- Mara Taraborelli,
- Rossella Reggia,
- Francesca Dall’Ara,
- Micaela Fredi,
- Laura Andreoli,
- Maria Gerosa,
- Ariela Hoxha,
- Laura Massaro,
- Marta Tonello,
- Nathalie Costedoat-Chalumeau,
- Patrice Cacoub,
- Franco Franceschini,
- Pier Luigi Meroni,
- Jean Charles Piette,
- Amelia Ruffatti,
- Guido Valesini,
- Eon Nigel Harris and
- Angela Tincani
- From the Rheumatology and Clinical Immunology Department, Spedali Civili and University of Brescia, Brescia; Division of Rheumatology, Department of Clinical Sciences and Community Health, Ospedale Gaetano Pini, University of Milan, Milan; Rheumatology Unit, Department of Medicine - DIMED, University of Padua, Padua; Internal Medicine and Medical Specialties Department, Policlinico Umberto I, La Sapienza University of Rome, Rome, Italy; AP-HP, Hôpital Cochin, Centre de référence maladies auto-immunes et systémiques rares, Service de Médecine Interne; AP-HP, Hospital Pitié-Salpêtrière, Centre de référence maladies auto-immunes et systémiques rares, Service de Médecine Interne, Pierre et Marie Curie Paris VI University, Paris, France; University of the West Indies, Kingston, Jamaica.
M. Taraborelli, MD, Rheumatology and Clinical Immunology Department, Spedali Civili and University of Brescia; R. Reggia, MD, Rheumatology and Clinical Immunology Department, Spedali Civili and University of Brescia; F. Dall’Ara, MD, Rheumatology and Clinical Immunology Department, Spedali Civili and University of Brescia; M. Fredi, MD, Rheumatology and Clinical Immunology Department, Spedali Civili and University of Brescia; L. Andreoli, MD, PhD, Rheumatology and Clinical Immunology Department, Spedali Civili and University of Brescia; M. Gerosa, MD, PhD, Division of Rheumatology, Department of Clinical Sciences and Community Health, Ospedale Gaetano Pini, University of Milan; A. Hoxha, MD, PhD, Rheumatology Unit, Department of Medicine - DIMED, University of Padua; L. Massaro, MD, Internal Medicine and Medical Specialties Department, Policlinico Umberto I, La Sapienza University of Rome; M. Tonello, BSc, PhD, Rheumatology Unit, Department of Medicine - DIMED, University of Padua; N. Costedoat-Chalumeau, MD, PhD, AP-HP, Hôpital Cochin, Centre de référence maladies auto-immunes et systémiques rares, Service de Médecine Interne; P. Cacoub, MD, PhD, AP-HP, Hospital Pitié-Salpêtrière, Centre de référence maladies auto-immunes et systémiques rares, Service de Médecine Interne, Pierre et Marie Curie Paris VI University; F. Franceschini, MD, Rheumatology and Clinical Immunology Department, Spedali Civili and University of Brescia; P.L. Meroni, MD, Division of Rheumatology, Department of Clinical Sciences and Community Health, Ospedale Gaetano Pini, University of Milan; J.C. Piette, MD, PhD, AP-HP, Hospital Pitié-Salpêtrière, Centre de référence maladies auto-immunes et systémiques rares, Service de Médecine Interne, Pierre et Marie Curie Paris VI University; A. Ruffatti, MD, PhD, Rheumatology Unit, Department of Medicine - DIMED, University of Padua; G. Valesini, MD, Internal Medicine and Medical Specialties Department, Policlinico Umberto I, La Sapienza University of Rome; E.N. Harris, MPhil, MD, DM, Vice Chancellor Emeritus, University of the West Indies; A. Tincani, MD, Rheumatology and Clinical Immunology Department, Spedali Civili and University of Brescia. Drs. Taraborelli, Reggia, and Dall’Ara contributed equally to this paper.
Address correspondence to Dr. A. Tincani, Rheumatology and Clinical Immunology Unit, Spedali Civili of Brescia, Piazzale Spedali Civili 1, 25123 Brescia, Italy. E-mail: angela.tincani@unibs.it.
Accepted for publication April 12, 2017.
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In this issue
The Journal of Rheumatology
Vol. 51, Issue 4
1 Apr 2024
Longterm Outcome of Patients with Primary Antiphospholipid Syndrome: A Retrospective Multicenter Study
Mara Taraborelli, Rossella Reggia, Francesca Dall’Ara, Micaela Fredi, Laura Andreoli, Maria Gerosa, Ariela Hoxha, Laura Massaro, Marta Tonello, Nathalie Costedoat-Chalumeau, Patrice Cacoub, Franco Franceschini, Pier Luigi Meroni, Jean Charles Piette, Amelia Ruffatti, Guido Valesini, Eon Nigel Harris, Angela Tincani
The Journal of Rheumatology Jun 2017, jrheum.161364; DOI: 10.3899/jrheum.161364
Longterm Outcome of Patients with Primary Antiphospholipid Syndrome: A Retrospective Multicenter Study
Mara Taraborelli, Rossella Reggia, Francesca Dall’Ara, Micaela Fredi, Laura Andreoli, Maria Gerosa, Ariela Hoxha, Laura Massaro, Marta Tonello, Nathalie Costedoat-Chalumeau, Patrice Cacoub, Franco Franceschini, Pier Luigi Meroni, Jean Charles Piette, Amelia Ruffatti, Guido Valesini, Eon Nigel Harris, Angela Tincani
The Journal of Rheumatology Jun 2017, jrheum.161364; DOI: 10.3899/jrheum.161364