Research ArticleArticle
Relationship Between Polymorphisms in Methotrexate Pathway Genes and Outcome of Methotrexate Treatment in a Cohort of 119 Patients with Juvenile Idiopathic Arthritis
Mojca Zajc Avramovič, Vita Dolžan, Nataša Toplak, Meta Accetto, Lara Lusa and Tadej Avčin
The Journal of Rheumatology June 2017, jrheum.160950; DOI: https://doi.org/10.3899/jrheum.160950
Mojca Zajc Avramovič
From the Department of Allergology, Rheumatology and Clinical Immunology, Children’s Hospital, University Medical Centre Ljubljana; Institute of Biochemistry, and Department of Pediatrics, and Institute for Biostatistics and Medical Informatics, Medical Faculty, University of Ljubljana, Ljubljana, Slovenia. Partially supported by the Slovenian Research Agency grants L3-4150, P3-0343, and P1-0170, and by the University Medical Center Ljubljana research grant 20140208. M. Zajc Avramovič, MD, Department of Allergology, Rheumatology and Clinical Immunology, Children’s Hospital, University Medical Centre Ljubljana; V. Dolžan, MD, PhD, Institute of Biochemistry, Medical Faculty, University of Ljubljana; N. Toplak, MD, PhD, Department of Allergology, Rheumatology and Clinical Immunology, Children’s Hospital, University Medical Centre Ljubljana, and Department of Pediatrics, Medical faculty, University of Ljubljana; M. Accetto, MD, Department of Allergology, Rheumatology and Clinical Immunology, Children’s Hospital, University Medical Centre Ljubljana; L. Lusa, PhD, Institute for Biostatistics and Medical Informatics, Medical Faculty, University of Ljubljana; T. Avčin, MD, PhD, Department of Allergology, Rheumatology and Clinical Immunology, Children’s Hospital, University Medical Centre Ljubljana, and Department of Pediatrics, Medical faculty, University of Ljubljana. Address correspondence to Dr. T. Avčin, Department of Allergology, Rheumatology and Clinical Immunology, Children’s Hospital, Bohoričeva 20, 1000 Ljubljana, Slovenia. E-mail: tadej.avcin@kclj.si. Accepted for publication April 5, 2017.
Vita Dolžan
From the Department of Allergology, Rheumatology and Clinical Immunology, Children’s Hospital, University Medical Centre Ljubljana; Institute of Biochemistry, and Department of Pediatrics, and Institute for Biostatistics and Medical Informatics, Medical Faculty, University of Ljubljana, Ljubljana, Slovenia. Partially supported by the Slovenian Research Agency grants L3-4150, P3-0343, and P1-0170, and by the University Medical Center Ljubljana research grant 20140208. M. Zajc Avramovič, MD, Department of Allergology, Rheumatology and Clinical Immunology, Children’s Hospital, University Medical Centre Ljubljana; V. Dolžan, MD, PhD, Institute of Biochemistry, Medical Faculty, University of Ljubljana; N. Toplak, MD, PhD, Department of Allergology, Rheumatology and Clinical Immunology, Children’s Hospital, University Medical Centre Ljubljana, and Department of Pediatrics, Medical faculty, University of Ljubljana; M. Accetto, MD, Department of Allergology, Rheumatology and Clinical Immunology, Children’s Hospital, University Medical Centre Ljubljana; L. Lusa, PhD, Institute for Biostatistics and Medical Informatics, Medical Faculty, University of Ljubljana; T. Avčin, MD, PhD, Department of Allergology, Rheumatology and Clinical Immunology, Children’s Hospital, University Medical Centre Ljubljana, and Department of Pediatrics, Medical faculty, University of Ljubljana. Address correspondence to Dr. T. Avčin, Department of Allergology, Rheumatology and Clinical Immunology, Children’s Hospital, Bohoričeva 20, 1000 Ljubljana, Slovenia. E-mail: tadej.avcin@kclj.si. Accepted for publication April 5, 2017.
Nataša Toplak
From the Department of Allergology, Rheumatology and Clinical Immunology, Children’s Hospital, University Medical Centre Ljubljana; Institute of Biochemistry, and Department of Pediatrics, and Institute for Biostatistics and Medical Informatics, Medical Faculty, University of Ljubljana, Ljubljana, Slovenia. Partially supported by the Slovenian Research Agency grants L3-4150, P3-0343, and P1-0170, and by the University Medical Center Ljubljana research grant 20140208. M. Zajc Avramovič, MD, Department of Allergology, Rheumatology and Clinical Immunology, Children’s Hospital, University Medical Centre Ljubljana; V. Dolžan, MD, PhD, Institute of Biochemistry, Medical Faculty, University of Ljubljana; N. Toplak, MD, PhD, Department of Allergology, Rheumatology and Clinical Immunology, Children’s Hospital, University Medical Centre Ljubljana, and Department of Pediatrics, Medical faculty, University of Ljubljana; M. Accetto, MD, Department of Allergology, Rheumatology and Clinical Immunology, Children’s Hospital, University Medical Centre Ljubljana; L. Lusa, PhD, Institute for Biostatistics and Medical Informatics, Medical Faculty, University of Ljubljana; T. Avčin, MD, PhD, Department of Allergology, Rheumatology and Clinical Immunology, Children’s Hospital, University Medical Centre Ljubljana, and Department of Pediatrics, Medical faculty, University of Ljubljana. Address correspondence to Dr. T. Avčin, Department of Allergology, Rheumatology and Clinical Immunology, Children’s Hospital, Bohoričeva 20, 1000 Ljubljana, Slovenia. E-mail: tadej.avcin@kclj.si. Accepted for publication April 5, 2017.
Meta Accetto
From the Department of Allergology, Rheumatology and Clinical Immunology, Children’s Hospital, University Medical Centre Ljubljana; Institute of Biochemistry, and Department of Pediatrics, and Institute for Biostatistics and Medical Informatics, Medical Faculty, University of Ljubljana, Ljubljana, Slovenia. Partially supported by the Slovenian Research Agency grants L3-4150, P3-0343, and P1-0170, and by the University Medical Center Ljubljana research grant 20140208. M. Zajc Avramovič, MD, Department of Allergology, Rheumatology and Clinical Immunology, Children’s Hospital, University Medical Centre Ljubljana; V. Dolžan, MD, PhD, Institute of Biochemistry, Medical Faculty, University of Ljubljana; N. Toplak, MD, PhD, Department of Allergology, Rheumatology and Clinical Immunology, Children’s Hospital, University Medical Centre Ljubljana, and Department of Pediatrics, Medical faculty, University of Ljubljana; M. Accetto, MD, Department of Allergology, Rheumatology and Clinical Immunology, Children’s Hospital, University Medical Centre Ljubljana; L. Lusa, PhD, Institute for Biostatistics and Medical Informatics, Medical Faculty, University of Ljubljana; T. Avčin, MD, PhD, Department of Allergology, Rheumatology and Clinical Immunology, Children’s Hospital, University Medical Centre Ljubljana, and Department of Pediatrics, Medical faculty, University of Ljubljana. Address correspondence to Dr. T. Avčin, Department of Allergology, Rheumatology and Clinical Immunology, Children’s Hospital, Bohoričeva 20, 1000 Ljubljana, Slovenia. E-mail: tadej.avcin@kclj.si. Accepted for publication April 5, 2017.
Lara Lusa
From the Department of Allergology, Rheumatology and Clinical Immunology, Children’s Hospital, University Medical Centre Ljubljana; Institute of Biochemistry, and Department of Pediatrics, and Institute for Biostatistics and Medical Informatics, Medical Faculty, University of Ljubljana, Ljubljana, Slovenia. Partially supported by the Slovenian Research Agency grants L3-4150, P3-0343, and P1-0170, and by the University Medical Center Ljubljana research grant 20140208. M. Zajc Avramovič, MD, Department of Allergology, Rheumatology and Clinical Immunology, Children’s Hospital, University Medical Centre Ljubljana; V. Dolžan, MD, PhD, Institute of Biochemistry, Medical Faculty, University of Ljubljana; N. Toplak, MD, PhD, Department of Allergology, Rheumatology and Clinical Immunology, Children’s Hospital, University Medical Centre Ljubljana, and Department of Pediatrics, Medical faculty, University of Ljubljana; M. Accetto, MD, Department of Allergology, Rheumatology and Clinical Immunology, Children’s Hospital, University Medical Centre Ljubljana; L. Lusa, PhD, Institute for Biostatistics and Medical Informatics, Medical Faculty, University of Ljubljana; T. Avčin, MD, PhD, Department of Allergology, Rheumatology and Clinical Immunology, Children’s Hospital, University Medical Centre Ljubljana, and Department of Pediatrics, Medical faculty, University of Ljubljana. Address correspondence to Dr. T. Avčin, Department of Allergology, Rheumatology and Clinical Immunology, Children’s Hospital, Bohoričeva 20, 1000 Ljubljana, Slovenia. E-mail: tadej.avcin@kclj.si. Accepted for publication April 5, 2017.
Tadej Avčin
From the Department of Allergology, Rheumatology and Clinical Immunology, Children’s Hospital, University Medical Centre Ljubljana; Institute of Biochemistry, and Department of Pediatrics, and Institute for Biostatistics and Medical Informatics, Medical Faculty, University of Ljubljana, Ljubljana, Slovenia. Partially supported by the Slovenian Research Agency grants L3-4150, P3-0343, and P1-0170, and by the University Medical Center Ljubljana research grant 20140208. M. Zajc Avramovič, MD, Department of Allergology, Rheumatology and Clinical Immunology, Children’s Hospital, University Medical Centre Ljubljana; V. Dolžan, MD, PhD, Institute of Biochemistry, Medical Faculty, University of Ljubljana; N. Toplak, MD, PhD, Department of Allergology, Rheumatology and Clinical Immunology, Children’s Hospital, University Medical Centre Ljubljana, and Department of Pediatrics, Medical faculty, University of Ljubljana; M. Accetto, MD, Department of Allergology, Rheumatology and Clinical Immunology, Children’s Hospital, University Medical Centre Ljubljana; L. Lusa, PhD, Institute for Biostatistics and Medical Informatics, Medical Faculty, University of Ljubljana; T. Avčin, MD, PhD, Department of Allergology, Rheumatology and Clinical Immunology, Children’s Hospital, University Medical Centre Ljubljana, and Department of Pediatrics, Medical faculty, University of Ljubljana. Address correspondence to Dr. T. Avčin, Department of Allergology, Rheumatology and Clinical Immunology, Children’s Hospital, Bohoričeva 20, 1000 Ljubljana, Slovenia. E-mail: tadej.avcin@kclj.si. Accepted for publication April 5, 2017.
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The Journal of Rheumatology
Vol. 51, Issue 3
1 Mar 2024
Relationship Between Polymorphisms in Methotrexate Pathway Genes and Outcome of Methotrexate Treatment in a Cohort of 119 Patients with Juvenile Idiopathic Arthritis
Mojca Zajc Avramovič, Vita Dolžan, Nataša Toplak, Meta Accetto, Lara Lusa, Tadej Avčin
The Journal of Rheumatology Jun 2017, jrheum.160950; DOI: 10.3899/jrheum.160950
Relationship Between Polymorphisms in Methotrexate Pathway Genes and Outcome of Methotrexate Treatment in a Cohort of 119 Patients with Juvenile Idiopathic Arthritis
Mojca Zajc Avramovič, Vita Dolžan, Nataša Toplak, Meta Accetto, Lara Lusa, Tadej Avčin
The Journal of Rheumatology Jun 2017, jrheum.160950; DOI: 10.3899/jrheum.160950