Research ArticleArticle
Elevated Expression of the NLRP3 Inflammasome and Its Correlation with Disease Activity in Adult-onset Still Disease
Chia-Wei Hsieh, Yi-Ming Chen, Chi-Chen Lin, Kuo-Tung Tang, Hsin-Hua Chen, Wei-Ting Hung, Kuo-Lung Lai and Der-Yuan Chen
The Journal of Rheumatology May 2017, jrheum.161354; DOI: https://doi.org/10.3899/jrheum.161354
Chia-Wei Hsieh
From the Division of Allergy, Immunology and Rheumatology, and the Department of Medical Education and Research, Taichung Veterans General Hospital, and PhD Program in Translational Medicine, and Institute of Biomedical Science and Rong Hsing Research Center for Translational Medicine, National Chung Hsing University, Taichung; Faculty of Medicine, National Yang Ming University, Taipei, Taiwan. Supported by a grant (NSC-101-2314-B-010-030-MY3) from the National Science Council, Taiwan. C.W. Hsieh, MD, Division of Allergy, Immunology and Rheumatology, Taichung Veterans General Hospital, and PhD Program in Translational Medicine, National Chung Hsing University; Y.M. Chen, MD, PhD, Division of Allergy, Immunology and Rheumatology, Taichung Veterans General Hospital, and Department of Medical Education and Research, Taichung Veterans General Hospital, and Faculty of Medicine, National Yang Ming University, and PhD Program in Translational Medicine, National Chung Hsing University; C.C. Lin, PhD, PhD Program in Translational Medicine, National Chung Hsing University, and Institute of Biomedical Science and Rong Hsing Research Center for Translational Medicine, National Chung Hsing University; K.T. Tang, MD, Division of Allergy, Immunology and Rheumatology, Taichung Veterans General Hospital, and PhD Program in Translational Medicine, National Chung Hsing University; H.H. Chen, MD, PhD, Division of Allergy, Immunology and Rheumatology, Taichung Veterans General Hospital, and Department of Medical Education and Research, Taichung Veterans General Hospital, and Faculty of Medicine, National Yang Ming University; W.T. Hung, MD, Division of Allergy, Immunology and Rheumatology, Taichung Veterans General Hospital, and Department of Medical Education and Research, Taichung Veterans General Hospital; K.L. Lai, MD, Division of Allergy, Immunology and Rheumatology, Taichung Veterans General Hospital, and Institute of Biomedical Science and Rong Hsing Research Center for Translational Medicine, National Chung Hsing University; D.Y. Chen, MD, PhD, Division of Allergy, Immunology and Rheumatology, Taichung Veterans General Hospital, and Department of Medical Education and Research, Taichung Veterans General Hospital, and Faculty of Medicine, National Yang Ming University, and PhD Program in Translational Medicine, National Chung Hsing University, and Institute of Biomedical Science and Rong Hsing Research Center for Translational Medicine, National Chung Hsing University. Dr. Y.M. Chen and C.C. Lin contributed equally to this work. Address correspondence to Dr. D.Y. Chen, Department of Medical Education and Research, Taichung Veterans General Hospital, No. 1650, Sec. 4, Taiwan Boulevard, Taichung 40705, Taiwan. E-mail: dychen@vghtc.gov.tw. Accepted for publication April 7, 2017.
Yi-Ming Chen
From the Division of Allergy, Immunology and Rheumatology, and the Department of Medical Education and Research, Taichung Veterans General Hospital, and PhD Program in Translational Medicine, and Institute of Biomedical Science and Rong Hsing Research Center for Translational Medicine, National Chung Hsing University, Taichung; Faculty of Medicine, National Yang Ming University, Taipei, Taiwan. Supported by a grant (NSC-101-2314-B-010-030-MY3) from the National Science Council, Taiwan. C.W. Hsieh, MD, Division of Allergy, Immunology and Rheumatology, Taichung Veterans General Hospital, and PhD Program in Translational Medicine, National Chung Hsing University; Y.M. Chen, MD, PhD, Division of Allergy, Immunology and Rheumatology, Taichung Veterans General Hospital, and Department of Medical Education and Research, Taichung Veterans General Hospital, and Faculty of Medicine, National Yang Ming University, and PhD Program in Translational Medicine, National Chung Hsing University; C.C. Lin, PhD, PhD Program in Translational Medicine, National Chung Hsing University, and Institute of Biomedical Science and Rong Hsing Research Center for Translational Medicine, National Chung Hsing University; K.T. Tang, MD, Division of Allergy, Immunology and Rheumatology, Taichung Veterans General Hospital, and PhD Program in Translational Medicine, National Chung Hsing University; H.H. Chen, MD, PhD, Division of Allergy, Immunology and Rheumatology, Taichung Veterans General Hospital, and Department of Medical Education and Research, Taichung Veterans General Hospital, and Faculty of Medicine, National Yang Ming University; W.T. Hung, MD, Division of Allergy, Immunology and Rheumatology, Taichung Veterans General Hospital, and Department of Medical Education and Research, Taichung Veterans General Hospital; K.L. Lai, MD, Division of Allergy, Immunology and Rheumatology, Taichung Veterans General Hospital, and Institute of Biomedical Science and Rong Hsing Research Center for Translational Medicine, National Chung Hsing University; D.Y. Chen, MD, PhD, Division of Allergy, Immunology and Rheumatology, Taichung Veterans General Hospital, and Department of Medical Education and Research, Taichung Veterans General Hospital, and Faculty of Medicine, National Yang Ming University, and PhD Program in Translational Medicine, National Chung Hsing University, and Institute of Biomedical Science and Rong Hsing Research Center for Translational Medicine, National Chung Hsing University. Dr. Y.M. Chen and C.C. Lin contributed equally to this work. Address correspondence to Dr. D.Y. Chen, Department of Medical Education and Research, Taichung Veterans General Hospital, No. 1650, Sec. 4, Taiwan Boulevard, Taichung 40705, Taiwan. E-mail: dychen@vghtc.gov.tw. Accepted for publication April 7, 2017.
Chi-Chen Lin
From the Division of Allergy, Immunology and Rheumatology, and the Department of Medical Education and Research, Taichung Veterans General Hospital, and PhD Program in Translational Medicine, and Institute of Biomedical Science and Rong Hsing Research Center for Translational Medicine, National Chung Hsing University, Taichung; Faculty of Medicine, National Yang Ming University, Taipei, Taiwan. Supported by a grant (NSC-101-2314-B-010-030-MY3) from the National Science Council, Taiwan. C.W. Hsieh, MD, Division of Allergy, Immunology and Rheumatology, Taichung Veterans General Hospital, and PhD Program in Translational Medicine, National Chung Hsing University; Y.M. Chen, MD, PhD, Division of Allergy, Immunology and Rheumatology, Taichung Veterans General Hospital, and Department of Medical Education and Research, Taichung Veterans General Hospital, and Faculty of Medicine, National Yang Ming University, and PhD Program in Translational Medicine, National Chung Hsing University; C.C. Lin, PhD, PhD Program in Translational Medicine, National Chung Hsing University, and Institute of Biomedical Science and Rong Hsing Research Center for Translational Medicine, National Chung Hsing University; K.T. Tang, MD, Division of Allergy, Immunology and Rheumatology, Taichung Veterans General Hospital, and PhD Program in Translational Medicine, National Chung Hsing University; H.H. Chen, MD, PhD, Division of Allergy, Immunology and Rheumatology, Taichung Veterans General Hospital, and Department of Medical Education and Research, Taichung Veterans General Hospital, and Faculty of Medicine, National Yang Ming University; W.T. Hung, MD, Division of Allergy, Immunology and Rheumatology, Taichung Veterans General Hospital, and Department of Medical Education and Research, Taichung Veterans General Hospital; K.L. Lai, MD, Division of Allergy, Immunology and Rheumatology, Taichung Veterans General Hospital, and Institute of Biomedical Science and Rong Hsing Research Center for Translational Medicine, National Chung Hsing University; D.Y. Chen, MD, PhD, Division of Allergy, Immunology and Rheumatology, Taichung Veterans General Hospital, and Department of Medical Education and Research, Taichung Veterans General Hospital, and Faculty of Medicine, National Yang Ming University, and PhD Program in Translational Medicine, National Chung Hsing University, and Institute of Biomedical Science and Rong Hsing Research Center for Translational Medicine, National Chung Hsing University. Dr. Y.M. Chen and C.C. Lin contributed equally to this work. Address correspondence to Dr. D.Y. Chen, Department of Medical Education and Research, Taichung Veterans General Hospital, No. 1650, Sec. 4, Taiwan Boulevard, Taichung 40705, Taiwan. E-mail: dychen@vghtc.gov.tw. Accepted for publication April 7, 2017.
Kuo-Tung Tang
From the Division of Allergy, Immunology and Rheumatology, and the Department of Medical Education and Research, Taichung Veterans General Hospital, and PhD Program in Translational Medicine, and Institute of Biomedical Science and Rong Hsing Research Center for Translational Medicine, National Chung Hsing University, Taichung; Faculty of Medicine, National Yang Ming University, Taipei, Taiwan. Supported by a grant (NSC-101-2314-B-010-030-MY3) from the National Science Council, Taiwan. C.W. Hsieh, MD, Division of Allergy, Immunology and Rheumatology, Taichung Veterans General Hospital, and PhD Program in Translational Medicine, National Chung Hsing University; Y.M. Chen, MD, PhD, Division of Allergy, Immunology and Rheumatology, Taichung Veterans General Hospital, and Department of Medical Education and Research, Taichung Veterans General Hospital, and Faculty of Medicine, National Yang Ming University, and PhD Program in Translational Medicine, National Chung Hsing University; C.C. Lin, PhD, PhD Program in Translational Medicine, National Chung Hsing University, and Institute of Biomedical Science and Rong Hsing Research Center for Translational Medicine, National Chung Hsing University; K.T. Tang, MD, Division of Allergy, Immunology and Rheumatology, Taichung Veterans General Hospital, and PhD Program in Translational Medicine, National Chung Hsing University; H.H. Chen, MD, PhD, Division of Allergy, Immunology and Rheumatology, Taichung Veterans General Hospital, and Department of Medical Education and Research, Taichung Veterans General Hospital, and Faculty of Medicine, National Yang Ming University; W.T. Hung, MD, Division of Allergy, Immunology and Rheumatology, Taichung Veterans General Hospital, and Department of Medical Education and Research, Taichung Veterans General Hospital; K.L. Lai, MD, Division of Allergy, Immunology and Rheumatology, Taichung Veterans General Hospital, and Institute of Biomedical Science and Rong Hsing Research Center for Translational Medicine, National Chung Hsing University; D.Y. Chen, MD, PhD, Division of Allergy, Immunology and Rheumatology, Taichung Veterans General Hospital, and Department of Medical Education and Research, Taichung Veterans General Hospital, and Faculty of Medicine, National Yang Ming University, and PhD Program in Translational Medicine, National Chung Hsing University, and Institute of Biomedical Science and Rong Hsing Research Center for Translational Medicine, National Chung Hsing University. Dr. Y.M. Chen and C.C. Lin contributed equally to this work. Address correspondence to Dr. D.Y. Chen, Department of Medical Education and Research, Taichung Veterans General Hospital, No. 1650, Sec. 4, Taiwan Boulevard, Taichung 40705, Taiwan. E-mail: dychen@vghtc.gov.tw. Accepted for publication April 7, 2017.
Hsin-Hua Chen
From the Division of Allergy, Immunology and Rheumatology, and the Department of Medical Education and Research, Taichung Veterans General Hospital, and PhD Program in Translational Medicine, and Institute of Biomedical Science and Rong Hsing Research Center for Translational Medicine, National Chung Hsing University, Taichung; Faculty of Medicine, National Yang Ming University, Taipei, Taiwan. Supported by a grant (NSC-101-2314-B-010-030-MY3) from the National Science Council, Taiwan. C.W. Hsieh, MD, Division of Allergy, Immunology and Rheumatology, Taichung Veterans General Hospital, and PhD Program in Translational Medicine, National Chung Hsing University; Y.M. Chen, MD, PhD, Division of Allergy, Immunology and Rheumatology, Taichung Veterans General Hospital, and Department of Medical Education and Research, Taichung Veterans General Hospital, and Faculty of Medicine, National Yang Ming University, and PhD Program in Translational Medicine, National Chung Hsing University; C.C. Lin, PhD, PhD Program in Translational Medicine, National Chung Hsing University, and Institute of Biomedical Science and Rong Hsing Research Center for Translational Medicine, National Chung Hsing University; K.T. Tang, MD, Division of Allergy, Immunology and Rheumatology, Taichung Veterans General Hospital, and PhD Program in Translational Medicine, National Chung Hsing University; H.H. Chen, MD, PhD, Division of Allergy, Immunology and Rheumatology, Taichung Veterans General Hospital, and Department of Medical Education and Research, Taichung Veterans General Hospital, and Faculty of Medicine, National Yang Ming University; W.T. Hung, MD, Division of Allergy, Immunology and Rheumatology, Taichung Veterans General Hospital, and Department of Medical Education and Research, Taichung Veterans General Hospital; K.L. Lai, MD, Division of Allergy, Immunology and Rheumatology, Taichung Veterans General Hospital, and Institute of Biomedical Science and Rong Hsing Research Center for Translational Medicine, National Chung Hsing University; D.Y. Chen, MD, PhD, Division of Allergy, Immunology and Rheumatology, Taichung Veterans General Hospital, and Department of Medical Education and Research, Taichung Veterans General Hospital, and Faculty of Medicine, National Yang Ming University, and PhD Program in Translational Medicine, National Chung Hsing University, and Institute of Biomedical Science and Rong Hsing Research Center for Translational Medicine, National Chung Hsing University. Dr. Y.M. Chen and C.C. Lin contributed equally to this work. Address correspondence to Dr. D.Y. Chen, Department of Medical Education and Research, Taichung Veterans General Hospital, No. 1650, Sec. 4, Taiwan Boulevard, Taichung 40705, Taiwan. E-mail: dychen@vghtc.gov.tw. Accepted for publication April 7, 2017.
Wei-Ting Hung
From the Division of Allergy, Immunology and Rheumatology, and the Department of Medical Education and Research, Taichung Veterans General Hospital, and PhD Program in Translational Medicine, and Institute of Biomedical Science and Rong Hsing Research Center for Translational Medicine, National Chung Hsing University, Taichung; Faculty of Medicine, National Yang Ming University, Taipei, Taiwan. Supported by a grant (NSC-101-2314-B-010-030-MY3) from the National Science Council, Taiwan. C.W. Hsieh, MD, Division of Allergy, Immunology and Rheumatology, Taichung Veterans General Hospital, and PhD Program in Translational Medicine, National Chung Hsing University; Y.M. Chen, MD, PhD, Division of Allergy, Immunology and Rheumatology, Taichung Veterans General Hospital, and Department of Medical Education and Research, Taichung Veterans General Hospital, and Faculty of Medicine, National Yang Ming University, and PhD Program in Translational Medicine, National Chung Hsing University; C.C. Lin, PhD, PhD Program in Translational Medicine, National Chung Hsing University, and Institute of Biomedical Science and Rong Hsing Research Center for Translational Medicine, National Chung Hsing University; K.T. Tang, MD, Division of Allergy, Immunology and Rheumatology, Taichung Veterans General Hospital, and PhD Program in Translational Medicine, National Chung Hsing University; H.H. Chen, MD, PhD, Division of Allergy, Immunology and Rheumatology, Taichung Veterans General Hospital, and Department of Medical Education and Research, Taichung Veterans General Hospital, and Faculty of Medicine, National Yang Ming University; W.T. Hung, MD, Division of Allergy, Immunology and Rheumatology, Taichung Veterans General Hospital, and Department of Medical Education and Research, Taichung Veterans General Hospital; K.L. Lai, MD, Division of Allergy, Immunology and Rheumatology, Taichung Veterans General Hospital, and Institute of Biomedical Science and Rong Hsing Research Center for Translational Medicine, National Chung Hsing University; D.Y. Chen, MD, PhD, Division of Allergy, Immunology and Rheumatology, Taichung Veterans General Hospital, and Department of Medical Education and Research, Taichung Veterans General Hospital, and Faculty of Medicine, National Yang Ming University, and PhD Program in Translational Medicine, National Chung Hsing University, and Institute of Biomedical Science and Rong Hsing Research Center for Translational Medicine, National Chung Hsing University. Dr. Y.M. Chen and C.C. Lin contributed equally to this work. Address correspondence to Dr. D.Y. Chen, Department of Medical Education and Research, Taichung Veterans General Hospital, No. 1650, Sec. 4, Taiwan Boulevard, Taichung 40705, Taiwan. E-mail: dychen@vghtc.gov.tw. Accepted for publication April 7, 2017.
Kuo-Lung Lai
From the Division of Allergy, Immunology and Rheumatology, and the Department of Medical Education and Research, Taichung Veterans General Hospital, and PhD Program in Translational Medicine, and Institute of Biomedical Science and Rong Hsing Research Center for Translational Medicine, National Chung Hsing University, Taichung; Faculty of Medicine, National Yang Ming University, Taipei, Taiwan. Supported by a grant (NSC-101-2314-B-010-030-MY3) from the National Science Council, Taiwan. C.W. Hsieh, MD, Division of Allergy, Immunology and Rheumatology, Taichung Veterans General Hospital, and PhD Program in Translational Medicine, National Chung Hsing University; Y.M. Chen, MD, PhD, Division of Allergy, Immunology and Rheumatology, Taichung Veterans General Hospital, and Department of Medical Education and Research, Taichung Veterans General Hospital, and Faculty of Medicine, National Yang Ming University, and PhD Program in Translational Medicine, National Chung Hsing University; C.C. Lin, PhD, PhD Program in Translational Medicine, National Chung Hsing University, and Institute of Biomedical Science and Rong Hsing Research Center for Translational Medicine, National Chung Hsing University; K.T. Tang, MD, Division of Allergy, Immunology and Rheumatology, Taichung Veterans General Hospital, and PhD Program in Translational Medicine, National Chung Hsing University; H.H. Chen, MD, PhD, Division of Allergy, Immunology and Rheumatology, Taichung Veterans General Hospital, and Department of Medical Education and Research, Taichung Veterans General Hospital, and Faculty of Medicine, National Yang Ming University; W.T. Hung, MD, Division of Allergy, Immunology and Rheumatology, Taichung Veterans General Hospital, and Department of Medical Education and Research, Taichung Veterans General Hospital; K.L. Lai, MD, Division of Allergy, Immunology and Rheumatology, Taichung Veterans General Hospital, and Institute of Biomedical Science and Rong Hsing Research Center for Translational Medicine, National Chung Hsing University; D.Y. Chen, MD, PhD, Division of Allergy, Immunology and Rheumatology, Taichung Veterans General Hospital, and Department of Medical Education and Research, Taichung Veterans General Hospital, and Faculty of Medicine, National Yang Ming University, and PhD Program in Translational Medicine, National Chung Hsing University, and Institute of Biomedical Science and Rong Hsing Research Center for Translational Medicine, National Chung Hsing University. Dr. Y.M. Chen and C.C. Lin contributed equally to this work. Address correspondence to Dr. D.Y. Chen, Department of Medical Education and Research, Taichung Veterans General Hospital, No. 1650, Sec. 4, Taiwan Boulevard, Taichung 40705, Taiwan. E-mail: dychen@vghtc.gov.tw. Accepted for publication April 7, 2017.
Der-Yuan Chen
From the Division of Allergy, Immunology and Rheumatology, and the Department of Medical Education and Research, Taichung Veterans General Hospital, and PhD Program in Translational Medicine, and Institute of Biomedical Science and Rong Hsing Research Center for Translational Medicine, National Chung Hsing University, Taichung; Faculty of Medicine, National Yang Ming University, Taipei, Taiwan. Supported by a grant (NSC-101-2314-B-010-030-MY3) from the National Science Council, Taiwan. C.W. Hsieh, MD, Division of Allergy, Immunology and Rheumatology, Taichung Veterans General Hospital, and PhD Program in Translational Medicine, National Chung Hsing University; Y.M. Chen, MD, PhD, Division of Allergy, Immunology and Rheumatology, Taichung Veterans General Hospital, and Department of Medical Education and Research, Taichung Veterans General Hospital, and Faculty of Medicine, National Yang Ming University, and PhD Program in Translational Medicine, National Chung Hsing University; C.C. Lin, PhD, PhD Program in Translational Medicine, National Chung Hsing University, and Institute of Biomedical Science and Rong Hsing Research Center for Translational Medicine, National Chung Hsing University; K.T. Tang, MD, Division of Allergy, Immunology and Rheumatology, Taichung Veterans General Hospital, and PhD Program in Translational Medicine, National Chung Hsing University; H.H. Chen, MD, PhD, Division of Allergy, Immunology and Rheumatology, Taichung Veterans General Hospital, and Department of Medical Education and Research, Taichung Veterans General Hospital, and Faculty of Medicine, National Yang Ming University; W.T. Hung, MD, Division of Allergy, Immunology and Rheumatology, Taichung Veterans General Hospital, and Department of Medical Education and Research, Taichung Veterans General Hospital; K.L. Lai, MD, Division of Allergy, Immunology and Rheumatology, Taichung Veterans General Hospital, and Institute of Biomedical Science and Rong Hsing Research Center for Translational Medicine, National Chung Hsing University; D.Y. Chen, MD, PhD, Division of Allergy, Immunology and Rheumatology, Taichung Veterans General Hospital, and Department of Medical Education and Research, Taichung Veterans General Hospital, and Faculty of Medicine, National Yang Ming University, and PhD Program in Translational Medicine, National Chung Hsing University, and Institute of Biomedical Science and Rong Hsing Research Center for Translational Medicine, National Chung Hsing University. Dr. Y.M. Chen and C.C. Lin contributed equally to this work. Address correspondence to Dr. D.Y. Chen, Department of Medical Education and Research, Taichung Veterans General Hospital, No. 1650, Sec. 4, Taiwan Boulevard, Taichung 40705, Taiwan. E-mail: dychen@vghtc.gov.tw. Accepted for publication April 7, 2017.
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In this issue
The Journal of Rheumatology
Vol. 51, Issue 4
1 Apr 2024
Elevated Expression of the NLRP3 Inflammasome and Its Correlation with Disease Activity in Adult-onset Still Disease
Chia-Wei Hsieh, Yi-Ming Chen, Chi-Chen Lin, Kuo-Tung Tang, Hsin-Hua Chen, Wei-Ting Hung, Kuo-Lung Lai, Der-Yuan Chen
The Journal of Rheumatology May 2017, jrheum.161354; DOI: 10.3899/jrheum.161354
Elevated Expression of the NLRP3 Inflammasome and Its Correlation with Disease Activity in Adult-onset Still Disease
Chia-Wei Hsieh, Yi-Ming Chen, Chi-Chen Lin, Kuo-Tung Tang, Hsin-Hua Chen, Wei-Ting Hung, Kuo-Lung Lai, Der-Yuan Chen
The Journal of Rheumatology May 2017, jrheum.161354; DOI: 10.3899/jrheum.161354