Research ArticleArticle
Poor Predictive Value of Isolated Adventitial and Periadventitial Infiltrates in Temporal Artery Biopsies for Diagnosis of Giant Cell Arteritis
Claire Le Pendu, Véronique Meignin, Solange Gonzalez-Chiappe, Adrian Hij, Françoise Galateau-Sallé and Alfred Mahr
The Journal of Rheumatology May 2017, jrheum.170061; DOI: https://doi.org/10.3899/jrheum.170061
Claire Le Pendu
From the Department of Internal Medicine, Unit for Systemic Diseases (UF07), and Department of Pathology, and Department of Internal Medicine, Unit for Autoimmune and Vascular Diseases (UF04), Saint-Louis University Hospital; ECSTRA Team, Epidemiology and Biostatistics, Sorbonne Paris Cité Research Center UMR 1153, INSERM, Paris; Department of Pathology, University Hospital Caen, Caen; Department of Biopathology, Léon-Bérard Cancer Center, Lyon, France. C. Le Pendu, MD, Department of Internal Medicine, Unit for Systemic Diseases (UF07), Saint-Louis University Hospital; V. Meignin, MD, Department of Pathology, Saint-Louis University Hospital; S. Gonzalez-Chiappe, MD, MPH, Department of Internal Medicine, Unit for Systemic Diseases (UF07), Saint-Louis University Hospital; A. Hij, MD, Department of Internal Medicine, Unit for Autoimmune and Vascular Diseases (UF04), Saint-Louis University Hospital; F. Galateau-Sallé, MD, PhD, Department of Pathology, University Hospital Caen, and Department of Biopathology, Léon-Bérard Cancer Center; A. Mahr, MD, MPH, PhD, Department of Internal Medicine, Unit for Systemic Diseases (UF07), Saint-Louis University Hospital, and ECSTRA Team, Epidemiology and Biostatistics, Sorbonne Paris Cité Research Center UMR 1153, INSERM. Address correspondence to Professor A. Mahr, Department of Internal Medicine, Hospital Saint-Louis, AP-HP, 1 avenue Claude-Vellefaux, 75475 Paris Cedex 10, France. E-mail: alfred.mahr@aphp.fr. Accepted for publication March 17, 2017.
Véronique Meignin
From the Department of Internal Medicine, Unit for Systemic Diseases (UF07), and Department of Pathology, and Department of Internal Medicine, Unit for Autoimmune and Vascular Diseases (UF04), Saint-Louis University Hospital; ECSTRA Team, Epidemiology and Biostatistics, Sorbonne Paris Cité Research Center UMR 1153, INSERM, Paris; Department of Pathology, University Hospital Caen, Caen; Department of Biopathology, Léon-Bérard Cancer Center, Lyon, France. C. Le Pendu, MD, Department of Internal Medicine, Unit for Systemic Diseases (UF07), Saint-Louis University Hospital; V. Meignin, MD, Department of Pathology, Saint-Louis University Hospital; S. Gonzalez-Chiappe, MD, MPH, Department of Internal Medicine, Unit for Systemic Diseases (UF07), Saint-Louis University Hospital; A. Hij, MD, Department of Internal Medicine, Unit for Autoimmune and Vascular Diseases (UF04), Saint-Louis University Hospital; F. Galateau-Sallé, MD, PhD, Department of Pathology, University Hospital Caen, and Department of Biopathology, Léon-Bérard Cancer Center; A. Mahr, MD, MPH, PhD, Department of Internal Medicine, Unit for Systemic Diseases (UF07), Saint-Louis University Hospital, and ECSTRA Team, Epidemiology and Biostatistics, Sorbonne Paris Cité Research Center UMR 1153, INSERM. Address correspondence to Professor A. Mahr, Department of Internal Medicine, Hospital Saint-Louis, AP-HP, 1 avenue Claude-Vellefaux, 75475 Paris Cedex 10, France. E-mail: alfred.mahr@aphp.fr. Accepted for publication March 17, 2017.
Solange Gonzalez-Chiappe
From the Department of Internal Medicine, Unit for Systemic Diseases (UF07), and Department of Pathology, and Department of Internal Medicine, Unit for Autoimmune and Vascular Diseases (UF04), Saint-Louis University Hospital; ECSTRA Team, Epidemiology and Biostatistics, Sorbonne Paris Cité Research Center UMR 1153, INSERM, Paris; Department of Pathology, University Hospital Caen, Caen; Department of Biopathology, Léon-Bérard Cancer Center, Lyon, France. C. Le Pendu, MD, Department of Internal Medicine, Unit for Systemic Diseases (UF07), Saint-Louis University Hospital; V. Meignin, MD, Department of Pathology, Saint-Louis University Hospital; S. Gonzalez-Chiappe, MD, MPH, Department of Internal Medicine, Unit for Systemic Diseases (UF07), Saint-Louis University Hospital; A. Hij, MD, Department of Internal Medicine, Unit for Autoimmune and Vascular Diseases (UF04), Saint-Louis University Hospital; F. Galateau-Sallé, MD, PhD, Department of Pathology, University Hospital Caen, and Department of Biopathology, Léon-Bérard Cancer Center; A. Mahr, MD, MPH, PhD, Department of Internal Medicine, Unit for Systemic Diseases (UF07), Saint-Louis University Hospital, and ECSTRA Team, Epidemiology and Biostatistics, Sorbonne Paris Cité Research Center UMR 1153, INSERM. Address correspondence to Professor A. Mahr, Department of Internal Medicine, Hospital Saint-Louis, AP-HP, 1 avenue Claude-Vellefaux, 75475 Paris Cedex 10, France. E-mail: alfred.mahr@aphp.fr. Accepted for publication March 17, 2017.
Adrian Hij
From the Department of Internal Medicine, Unit for Systemic Diseases (UF07), and Department of Pathology, and Department of Internal Medicine, Unit for Autoimmune and Vascular Diseases (UF04), Saint-Louis University Hospital; ECSTRA Team, Epidemiology and Biostatistics, Sorbonne Paris Cité Research Center UMR 1153, INSERM, Paris; Department of Pathology, University Hospital Caen, Caen; Department of Biopathology, Léon-Bérard Cancer Center, Lyon, France. C. Le Pendu, MD, Department of Internal Medicine, Unit for Systemic Diseases (UF07), Saint-Louis University Hospital; V. Meignin, MD, Department of Pathology, Saint-Louis University Hospital; S. Gonzalez-Chiappe, MD, MPH, Department of Internal Medicine, Unit for Systemic Diseases (UF07), Saint-Louis University Hospital; A. Hij, MD, Department of Internal Medicine, Unit for Autoimmune and Vascular Diseases (UF04), Saint-Louis University Hospital; F. Galateau-Sallé, MD, PhD, Department of Pathology, University Hospital Caen, and Department of Biopathology, Léon-Bérard Cancer Center; A. Mahr, MD, MPH, PhD, Department of Internal Medicine, Unit for Systemic Diseases (UF07), Saint-Louis University Hospital, and ECSTRA Team, Epidemiology and Biostatistics, Sorbonne Paris Cité Research Center UMR 1153, INSERM. Address correspondence to Professor A. Mahr, Department of Internal Medicine, Hospital Saint-Louis, AP-HP, 1 avenue Claude-Vellefaux, 75475 Paris Cedex 10, France. E-mail: alfred.mahr@aphp.fr. Accepted for publication March 17, 2017.
Françoise Galateau-Sallé
From the Department of Internal Medicine, Unit for Systemic Diseases (UF07), and Department of Pathology, and Department of Internal Medicine, Unit for Autoimmune and Vascular Diseases (UF04), Saint-Louis University Hospital; ECSTRA Team, Epidemiology and Biostatistics, Sorbonne Paris Cité Research Center UMR 1153, INSERM, Paris; Department of Pathology, University Hospital Caen, Caen; Department of Biopathology, Léon-Bérard Cancer Center, Lyon, France. C. Le Pendu, MD, Department of Internal Medicine, Unit for Systemic Diseases (UF07), Saint-Louis University Hospital; V. Meignin, MD, Department of Pathology, Saint-Louis University Hospital; S. Gonzalez-Chiappe, MD, MPH, Department of Internal Medicine, Unit for Systemic Diseases (UF07), Saint-Louis University Hospital; A. Hij, MD, Department of Internal Medicine, Unit for Autoimmune and Vascular Diseases (UF04), Saint-Louis University Hospital; F. Galateau-Sallé, MD, PhD, Department of Pathology, University Hospital Caen, and Department of Biopathology, Léon-Bérard Cancer Center; A. Mahr, MD, MPH, PhD, Department of Internal Medicine, Unit for Systemic Diseases (UF07), Saint-Louis University Hospital, and ECSTRA Team, Epidemiology and Biostatistics, Sorbonne Paris Cité Research Center UMR 1153, INSERM. Address correspondence to Professor A. Mahr, Department of Internal Medicine, Hospital Saint-Louis, AP-HP, 1 avenue Claude-Vellefaux, 75475 Paris Cedex 10, France. E-mail: alfred.mahr@aphp.fr. Accepted for publication March 17, 2017.
Alfred Mahr
From the Department of Internal Medicine, Unit for Systemic Diseases (UF07), and Department of Pathology, and Department of Internal Medicine, Unit for Autoimmune and Vascular Diseases (UF04), Saint-Louis University Hospital; ECSTRA Team, Epidemiology and Biostatistics, Sorbonne Paris Cité Research Center UMR 1153, INSERM, Paris; Department of Pathology, University Hospital Caen, Caen; Department of Biopathology, Léon-Bérard Cancer Center, Lyon, France. C. Le Pendu, MD, Department of Internal Medicine, Unit for Systemic Diseases (UF07), Saint-Louis University Hospital; V. Meignin, MD, Department of Pathology, Saint-Louis University Hospital; S. Gonzalez-Chiappe, MD, MPH, Department of Internal Medicine, Unit for Systemic Diseases (UF07), Saint-Louis University Hospital; A. Hij, MD, Department of Internal Medicine, Unit for Autoimmune and Vascular Diseases (UF04), Saint-Louis University Hospital; F. Galateau-Sallé, MD, PhD, Department of Pathology, University Hospital Caen, and Department of Biopathology, Léon-Bérard Cancer Center; A. Mahr, MD, MPH, PhD, Department of Internal Medicine, Unit for Systemic Diseases (UF07), Saint-Louis University Hospital, and ECSTRA Team, Epidemiology and Biostatistics, Sorbonne Paris Cité Research Center UMR 1153, INSERM. Address correspondence to Professor A. Mahr, Department of Internal Medicine, Hospital Saint-Louis, AP-HP, 1 avenue Claude-Vellefaux, 75475 Paris Cedex 10, France. E-mail: alfred.mahr@aphp.fr. Accepted for publication March 17, 2017.
Abstract
Objective We investigated the diagnostic value of inflammation limited to the adventitia (ILA), and isolated vasa vasorum or small-vessel vasculitis (VVV, SVV) in temporal artery biopsies (TAB) for giant cell arteritis (GCA).
Methods Two pathologists reviewed consecutive first TAB. Using the clinical diagnoses as the gold standard, positive predictive values (PPV) were calculated.
Results Among the 75 patients without classic TAB features of GCA, 8 had GCA diagnoses. The PPV of ILA, VVV, and SVV seen by either or both pathologists were 17%, 0%, and 7%, and 17%, 0%, and 10%, respectively.
Conclusion (Peri)adventitial infiltrates in TAB poorly predict GCA.
In this issue
The Journal of Rheumatology
Vol. 51, Issue 3
1 Mar 2024
Poor Predictive Value of Isolated Adventitial and Periadventitial Infiltrates in Temporal Artery Biopsies for Diagnosis of Giant Cell Arteritis
Claire Le Pendu, Véronique Meignin, Solange Gonzalez-Chiappe, Adrian Hij, Françoise Galateau-Sallé, Alfred Mahr
The Journal of Rheumatology May 2017, jrheum.170061; DOI: 10.3899/jrheum.170061
Poor Predictive Value of Isolated Adventitial and Periadventitial Infiltrates in Temporal Artery Biopsies for Diagnosis of Giant Cell Arteritis
Claire Le Pendu, Véronique Meignin, Solange Gonzalez-Chiappe, Adrian Hij, Françoise Galateau-Sallé, Alfred Mahr
The Journal of Rheumatology May 2017, jrheum.170061; DOI: 10.3899/jrheum.170061