Research ArticleArticle
Prevalence of Anti-infliximab Antibodies and Their Associated Co-factors in Children with Refractory Arthritis and/or Uveitis: A Retrospective Longitudinal Cohort Study
Florence A. Aeschlimann, Felix Angst, Kevin D. Hofer, Elvira Cannizzaro Schneider, Silke Schroeder-Kohler, Roger Lauener, Desirée van der Kleij, Theo Rispens and Rotraud K. Saurenmann
The Journal of Rheumatology January 2017, jrheum.160072; DOI: https://doi.org/10.3899/jrheum.160072
Florence A. Aeschlimann
From the Department of Rheumatology, University Children’s Hospital, Zurich; RehaClinic Bad Zurzach, Bad Zurzach; Department of Pediatrics, Ostschweizer Kinderspital, St. Gallen, Switzerland; Laboratory for Biologicals, Sanquin; Department of Immunopathology, Sanquin Research; Landsteiner Academic Medical Centre, Amsterdam, the Netherlands; Department of Pediatrics, Kantonsspital Winterthur, Winterthur, Switzerland. Laboratory testing was funded by miscellaneous donations collected in the research fund of the rheumatology department, University Children’s Hospital, Zurich. T. Rispens received a research grant from Genmab. F.A. Aeschlimann, MD, rheumatology fellow, currently at the Division of Rheumatology, The Hospital for Sick Children, Toronto, Ontario, Canada; F. Angst, MD, MPH, RehaClinic Bad Zurzach; K.D. Hofer, medical student, Department of Rheumatology, University Children’s Hospital; E. Cannizzaro Schneider, MD, staff pediatric rheumatologist, Department of Rheumatology, University Children’s Hospital; S. Schroeder-Kohler, MD, staff pediatric rheumatologist, Department of Rheumatology, University Children’s Hospital; R. Lauener, MD, Professor, head of pediatric department, Ostschweizer Kinderspital; D. van der Kleij, PhD, head of Laboratory for Biologicals, Sanquin; T. Rispens, PhD, Department of Immunopathology, Sanquin Research, and Landsteiner Laboratory Academic Medical Centre; R.K. Saurenmann, MD, Professor, head of pediatric department, pediatric rheumatologist, Department of Rheumatology, University Children’s Hospital, and Kantonsspital Winterthur. Address correspondence to Dr. R.K. Saurenmann, University Children’s Hospital Zurich, 8032 Zurich, Switzerland. E-mail: traudel.saurenmann@kispi.uzh.ch. Accepted for publication November 24, 2016.
Felix Angst
From the Department of Rheumatology, University Children’s Hospital, Zurich; RehaClinic Bad Zurzach, Bad Zurzach; Department of Pediatrics, Ostschweizer Kinderspital, St. Gallen, Switzerland; Laboratory for Biologicals, Sanquin; Department of Immunopathology, Sanquin Research; Landsteiner Academic Medical Centre, Amsterdam, the Netherlands; Department of Pediatrics, Kantonsspital Winterthur, Winterthur, Switzerland. Laboratory testing was funded by miscellaneous donations collected in the research fund of the rheumatology department, University Children’s Hospital, Zurich. T. Rispens received a research grant from Genmab. F.A. Aeschlimann, MD, rheumatology fellow, currently at the Division of Rheumatology, The Hospital for Sick Children, Toronto, Ontario, Canada; F. Angst, MD, MPH, RehaClinic Bad Zurzach; K.D. Hofer, medical student, Department of Rheumatology, University Children’s Hospital; E. Cannizzaro Schneider, MD, staff pediatric rheumatologist, Department of Rheumatology, University Children’s Hospital; S. Schroeder-Kohler, MD, staff pediatric rheumatologist, Department of Rheumatology, University Children’s Hospital; R. Lauener, MD, Professor, head of pediatric department, Ostschweizer Kinderspital; D. van der Kleij, PhD, head of Laboratory for Biologicals, Sanquin; T. Rispens, PhD, Department of Immunopathology, Sanquin Research, and Landsteiner Laboratory Academic Medical Centre; R.K. Saurenmann, MD, Professor, head of pediatric department, pediatric rheumatologist, Department of Rheumatology, University Children’s Hospital, and Kantonsspital Winterthur. Address correspondence to Dr. R.K. Saurenmann, University Children’s Hospital Zurich, 8032 Zurich, Switzerland. E-mail: traudel.saurenmann@kispi.uzh.ch. Accepted for publication November 24, 2016.
Kevin D. Hofer
From the Department of Rheumatology, University Children’s Hospital, Zurich; RehaClinic Bad Zurzach, Bad Zurzach; Department of Pediatrics, Ostschweizer Kinderspital, St. Gallen, Switzerland; Laboratory for Biologicals, Sanquin; Department of Immunopathology, Sanquin Research; Landsteiner Academic Medical Centre, Amsterdam, the Netherlands; Department of Pediatrics, Kantonsspital Winterthur, Winterthur, Switzerland. Laboratory testing was funded by miscellaneous donations collected in the research fund of the rheumatology department, University Children’s Hospital, Zurich. T. Rispens received a research grant from Genmab. F.A. Aeschlimann, MD, rheumatology fellow, currently at the Division of Rheumatology, The Hospital for Sick Children, Toronto, Ontario, Canada; F. Angst, MD, MPH, RehaClinic Bad Zurzach; K.D. Hofer, medical student, Department of Rheumatology, University Children’s Hospital; E. Cannizzaro Schneider, MD, staff pediatric rheumatologist, Department of Rheumatology, University Children’s Hospital; S. Schroeder-Kohler, MD, staff pediatric rheumatologist, Department of Rheumatology, University Children’s Hospital; R. Lauener, MD, Professor, head of pediatric department, Ostschweizer Kinderspital; D. van der Kleij, PhD, head of Laboratory for Biologicals, Sanquin; T. Rispens, PhD, Department of Immunopathology, Sanquin Research, and Landsteiner Laboratory Academic Medical Centre; R.K. Saurenmann, MD, Professor, head of pediatric department, pediatric rheumatologist, Department of Rheumatology, University Children’s Hospital, and Kantonsspital Winterthur. Address correspondence to Dr. R.K. Saurenmann, University Children’s Hospital Zurich, 8032 Zurich, Switzerland. E-mail: traudel.saurenmann@kispi.uzh.ch. Accepted for publication November 24, 2016.
Elvira Cannizzaro Schneider
From the Department of Rheumatology, University Children’s Hospital, Zurich; RehaClinic Bad Zurzach, Bad Zurzach; Department of Pediatrics, Ostschweizer Kinderspital, St. Gallen, Switzerland; Laboratory for Biologicals, Sanquin; Department of Immunopathology, Sanquin Research; Landsteiner Academic Medical Centre, Amsterdam, the Netherlands; Department of Pediatrics, Kantonsspital Winterthur, Winterthur, Switzerland. Laboratory testing was funded by miscellaneous donations collected in the research fund of the rheumatology department, University Children’s Hospital, Zurich. T. Rispens received a research grant from Genmab. F.A. Aeschlimann, MD, rheumatology fellow, currently at the Division of Rheumatology, The Hospital for Sick Children, Toronto, Ontario, Canada; F. Angst, MD, MPH, RehaClinic Bad Zurzach; K.D. Hofer, medical student, Department of Rheumatology, University Children’s Hospital; E. Cannizzaro Schneider, MD, staff pediatric rheumatologist, Department of Rheumatology, University Children’s Hospital; S. Schroeder-Kohler, MD, staff pediatric rheumatologist, Department of Rheumatology, University Children’s Hospital; R. Lauener, MD, Professor, head of pediatric department, Ostschweizer Kinderspital; D. van der Kleij, PhD, head of Laboratory for Biologicals, Sanquin; T. Rispens, PhD, Department of Immunopathology, Sanquin Research, and Landsteiner Laboratory Academic Medical Centre; R.K. Saurenmann, MD, Professor, head of pediatric department, pediatric rheumatologist, Department of Rheumatology, University Children’s Hospital, and Kantonsspital Winterthur. Address correspondence to Dr. R.K. Saurenmann, University Children’s Hospital Zurich, 8032 Zurich, Switzerland. E-mail: traudel.saurenmann@kispi.uzh.ch. Accepted for publication November 24, 2016.
Silke Schroeder-Kohler
From the Department of Rheumatology, University Children’s Hospital, Zurich; RehaClinic Bad Zurzach, Bad Zurzach; Department of Pediatrics, Ostschweizer Kinderspital, St. Gallen, Switzerland; Laboratory for Biologicals, Sanquin; Department of Immunopathology, Sanquin Research; Landsteiner Academic Medical Centre, Amsterdam, the Netherlands; Department of Pediatrics, Kantonsspital Winterthur, Winterthur, Switzerland. Laboratory testing was funded by miscellaneous donations collected in the research fund of the rheumatology department, University Children’s Hospital, Zurich. T. Rispens received a research grant from Genmab. F.A. Aeschlimann, MD, rheumatology fellow, currently at the Division of Rheumatology, The Hospital for Sick Children, Toronto, Ontario, Canada; F. Angst, MD, MPH, RehaClinic Bad Zurzach; K.D. Hofer, medical student, Department of Rheumatology, University Children’s Hospital; E. Cannizzaro Schneider, MD, staff pediatric rheumatologist, Department of Rheumatology, University Children’s Hospital; S. Schroeder-Kohler, MD, staff pediatric rheumatologist, Department of Rheumatology, University Children’s Hospital; R. Lauener, MD, Professor, head of pediatric department, Ostschweizer Kinderspital; D. van der Kleij, PhD, head of Laboratory for Biologicals, Sanquin; T. Rispens, PhD, Department of Immunopathology, Sanquin Research, and Landsteiner Laboratory Academic Medical Centre; R.K. Saurenmann, MD, Professor, head of pediatric department, pediatric rheumatologist, Department of Rheumatology, University Children’s Hospital, and Kantonsspital Winterthur. Address correspondence to Dr. R.K. Saurenmann, University Children’s Hospital Zurich, 8032 Zurich, Switzerland. E-mail: traudel.saurenmann@kispi.uzh.ch. Accepted for publication November 24, 2016.
Roger Lauener
From the Department of Rheumatology, University Children’s Hospital, Zurich; RehaClinic Bad Zurzach, Bad Zurzach; Department of Pediatrics, Ostschweizer Kinderspital, St. Gallen, Switzerland; Laboratory for Biologicals, Sanquin; Department of Immunopathology, Sanquin Research; Landsteiner Academic Medical Centre, Amsterdam, the Netherlands; Department of Pediatrics, Kantonsspital Winterthur, Winterthur, Switzerland. Laboratory testing was funded by miscellaneous donations collected in the research fund of the rheumatology department, University Children’s Hospital, Zurich. T. Rispens received a research grant from Genmab. F.A. Aeschlimann, MD, rheumatology fellow, currently at the Division of Rheumatology, The Hospital for Sick Children, Toronto, Ontario, Canada; F. Angst, MD, MPH, RehaClinic Bad Zurzach; K.D. Hofer, medical student, Department of Rheumatology, University Children’s Hospital; E. Cannizzaro Schneider, MD, staff pediatric rheumatologist, Department of Rheumatology, University Children’s Hospital; S. Schroeder-Kohler, MD, staff pediatric rheumatologist, Department of Rheumatology, University Children’s Hospital; R. Lauener, MD, Professor, head of pediatric department, Ostschweizer Kinderspital; D. van der Kleij, PhD, head of Laboratory for Biologicals, Sanquin; T. Rispens, PhD, Department of Immunopathology, Sanquin Research, and Landsteiner Laboratory Academic Medical Centre; R.K. Saurenmann, MD, Professor, head of pediatric department, pediatric rheumatologist, Department of Rheumatology, University Children’s Hospital, and Kantonsspital Winterthur. Address correspondence to Dr. R.K. Saurenmann, University Children’s Hospital Zurich, 8032 Zurich, Switzerland. E-mail: traudel.saurenmann@kispi.uzh.ch. Accepted for publication November 24, 2016.
Desirée van der Kleij
From the Department of Rheumatology, University Children’s Hospital, Zurich; RehaClinic Bad Zurzach, Bad Zurzach; Department of Pediatrics, Ostschweizer Kinderspital, St. Gallen, Switzerland; Laboratory for Biologicals, Sanquin; Department of Immunopathology, Sanquin Research; Landsteiner Academic Medical Centre, Amsterdam, the Netherlands; Department of Pediatrics, Kantonsspital Winterthur, Winterthur, Switzerland. Laboratory testing was funded by miscellaneous donations collected in the research fund of the rheumatology department, University Children’s Hospital, Zurich. T. Rispens received a research grant from Genmab. F.A. Aeschlimann, MD, rheumatology fellow, currently at the Division of Rheumatology, The Hospital for Sick Children, Toronto, Ontario, Canada; F. Angst, MD, MPH, RehaClinic Bad Zurzach; K.D. Hofer, medical student, Department of Rheumatology, University Children’s Hospital; E. Cannizzaro Schneider, MD, staff pediatric rheumatologist, Department of Rheumatology, University Children’s Hospital; S. Schroeder-Kohler, MD, staff pediatric rheumatologist, Department of Rheumatology, University Children’s Hospital; R. Lauener, MD, Professor, head of pediatric department, Ostschweizer Kinderspital; D. van der Kleij, PhD, head of Laboratory for Biologicals, Sanquin; T. Rispens, PhD, Department of Immunopathology, Sanquin Research, and Landsteiner Laboratory Academic Medical Centre; R.K. Saurenmann, MD, Professor, head of pediatric department, pediatric rheumatologist, Department of Rheumatology, University Children’s Hospital, and Kantonsspital Winterthur. Address correspondence to Dr. R.K. Saurenmann, University Children’s Hospital Zurich, 8032 Zurich, Switzerland. E-mail: traudel.saurenmann@kispi.uzh.ch. Accepted for publication November 24, 2016.
Theo Rispens
From the Department of Rheumatology, University Children’s Hospital, Zurich; RehaClinic Bad Zurzach, Bad Zurzach; Department of Pediatrics, Ostschweizer Kinderspital, St. Gallen, Switzerland; Laboratory for Biologicals, Sanquin; Department of Immunopathology, Sanquin Research; Landsteiner Academic Medical Centre, Amsterdam, the Netherlands; Department of Pediatrics, Kantonsspital Winterthur, Winterthur, Switzerland. Laboratory testing was funded by miscellaneous donations collected in the research fund of the rheumatology department, University Children’s Hospital, Zurich. T. Rispens received a research grant from Genmab. F.A. Aeschlimann, MD, rheumatology fellow, currently at the Division of Rheumatology, The Hospital for Sick Children, Toronto, Ontario, Canada; F. Angst, MD, MPH, RehaClinic Bad Zurzach; K.D. Hofer, medical student, Department of Rheumatology, University Children’s Hospital; E. Cannizzaro Schneider, MD, staff pediatric rheumatologist, Department of Rheumatology, University Children’s Hospital; S. Schroeder-Kohler, MD, staff pediatric rheumatologist, Department of Rheumatology, University Children’s Hospital; R. Lauener, MD, Professor, head of pediatric department, Ostschweizer Kinderspital; D. van der Kleij, PhD, head of Laboratory for Biologicals, Sanquin; T. Rispens, PhD, Department of Immunopathology, Sanquin Research, and Landsteiner Laboratory Academic Medical Centre; R.K. Saurenmann, MD, Professor, head of pediatric department, pediatric rheumatologist, Department of Rheumatology, University Children’s Hospital, and Kantonsspital Winterthur. Address correspondence to Dr. R.K. Saurenmann, University Children’s Hospital Zurich, 8032 Zurich, Switzerland. E-mail: traudel.saurenmann@kispi.uzh.ch. Accepted for publication November 24, 2016.
Rotraud K. Saurenmann
From the Department of Rheumatology, University Children’s Hospital, Zurich; RehaClinic Bad Zurzach, Bad Zurzach; Department of Pediatrics, Ostschweizer Kinderspital, St. Gallen, Switzerland; Laboratory for Biologicals, Sanquin; Department of Immunopathology, Sanquin Research; Landsteiner Academic Medical Centre, Amsterdam, the Netherlands; Department of Pediatrics, Kantonsspital Winterthur, Winterthur, Switzerland. Laboratory testing was funded by miscellaneous donations collected in the research fund of the rheumatology department, University Children’s Hospital, Zurich. T. Rispens received a research grant from Genmab. F.A. Aeschlimann, MD, rheumatology fellow, currently at the Division of Rheumatology, The Hospital for Sick Children, Toronto, Ontario, Canada; F. Angst, MD, MPH, RehaClinic Bad Zurzach; K.D. Hofer, medical student, Department of Rheumatology, University Children’s Hospital; E. Cannizzaro Schneider, MD, staff pediatric rheumatologist, Department of Rheumatology, University Children’s Hospital; S. Schroeder-Kohler, MD, staff pediatric rheumatologist, Department of Rheumatology, University Children’s Hospital; R. Lauener, MD, Professor, head of pediatric department, Ostschweizer Kinderspital; D. van der Kleij, PhD, head of Laboratory for Biologicals, Sanquin; T. Rispens, PhD, Department of Immunopathology, Sanquin Research, and Landsteiner Laboratory Academic Medical Centre; R.K. Saurenmann, MD, Professor, head of pediatric department, pediatric rheumatologist, Department of Rheumatology, University Children’s Hospital, and Kantonsspital Winterthur. Address correspondence to Dr. R.K. Saurenmann, University Children’s Hospital Zurich, 8032 Zurich, Switzerland. E-mail: traudel.saurenmann@kispi.uzh.ch. Accepted for publication November 24, 2016.
Published eLetters
eLetters are comments published online only and are not peer-reviewed. Publication of eLetter submissions is not guaranteed, and all submissions are reviewed and edited at the discretion of The Journal's staff.
If you wish to publish Letters to the Editor or Correspondence, please submit through our online submission system ScholarOne Manuscripts.
Jump to comment:
No eLetters have been published for this article.
In this issue
The Journal of Rheumatology
Vol. 51, Issue 4
1 Apr 2024
Prevalence of Anti-infliximab Antibodies and Their Associated Co-factors in Children with Refractory Arthritis and/or Uveitis: A Retrospective Longitudinal Cohort Study
Florence A. Aeschlimann, Felix Angst, Kevin D. Hofer, Elvira Cannizzaro Schneider, Silke Schroeder-Kohler, Roger Lauener, Desirée van der Kleij, Theo Rispens, Rotraud K. Saurenmann
The Journal of Rheumatology Jan 2017, jrheum.160072; DOI: 10.3899/jrheum.160072
Prevalence of Anti-infliximab Antibodies and Their Associated Co-factors in Children with Refractory Arthritis and/or Uveitis: A Retrospective Longitudinal Cohort Study
Florence A. Aeschlimann, Felix Angst, Kevin D. Hofer, Elvira Cannizzaro Schneider, Silke Schroeder-Kohler, Roger Lauener, Desirée van der Kleij, Theo Rispens, Rotraud K. Saurenmann
The Journal of Rheumatology Jan 2017, jrheum.160072; DOI: 10.3899/jrheum.160072