Research ArticleArticle
Open Access
Effects of Longterm Treatment with Bosentan and Iloprost on Nailfold Absolute Capillary Number, Fingertip Blood Perfusion, and Clinical Status in Systemic Sclerosis
Amelia Chiara Trombetta, Carmen Pizzorni, Barbara Ruaro, Sabrina Paolino, Alberto Sulli, Vanessa Smith and Maurizio Cutolo
The Journal of Rheumatology October 2016, jrheum.160592; DOI: https://doi.org/10.3899/jrheum.160592
Amelia Chiara Trombetta
From the Research Laboratory and Academic Division of Clinical Rheumatology, Department of Internal Medicine, University of Genoa, Genoa, Italy; Department of Rheumatology, Ghent University Hospital, Ghent University, Ghent, Belgium. V. Smith is supported by a research grant of the Research Foundation — Flanders (Belgium; FWO; Grant number: 1.5.217.13N) and is Senior Clinical Investigator of the Research Foundation — Flanders (Belgium; FWO). A.C. Trombetta, MD, PhD, Trainee in Clinical and Experimental Immunology, Research Laboratory and Academic Division of Clinical Rheumatology, Department of Internal Medicine, University of Genoa; C. Pizzorni, MD, PhD, Assistant Professor of Rheumatology, Research Laboratory and Academic Division of Clinical Rheumatology, Department of Internal Medicine, University of Genoa; B. Ruaro, MD, Trainee in Rheumatology, Research Laboratory and Academic Division of Clinical Rheumatology, Department of Internal Medicine, University of Genoa; S. Paolino, MD, Assistant Professor of Rheumatology, Research Laboratory and Academic Division of Clinical Rheumatology, Department of Internal Medicine, University of Genoa; A. Sulli, MD, Associate Professor of Rheumatology, Research Laboratory and Academic Division of Clinical Rheumatology, Department of Internal Medicine, University of Genoa; V. Smith, MD, PhD, Associate Professor of Rheumatology, Head of Clinics in Rheumatology, Ghent University Hospital, Ghent University; M. Cutolo, MD, Full Professor of Rheumatology, Research Laboratory and Academic Division of Clinical Rheumatology, Department of Internal Medicine, University of Genoa. Address correspondence to Dr. M. Cutolo, Research Laboratory and Academic Division of Clinical Rheumatology, Department of Internal Medicine, IRCCS San Martino AOU, University of Genoa, Viale Benedetto XV n. 6, 16132 Genoa, Italy. E-mail: mcutolo@unige.it. Full Release article. For details see Reprints/Permissions at jrheum.org. Accepted for publication August 25, 2016.
Carmen Pizzorni
From the Research Laboratory and Academic Division of Clinical Rheumatology, Department of Internal Medicine, University of Genoa, Genoa, Italy; Department of Rheumatology, Ghent University Hospital, Ghent University, Ghent, Belgium. V. Smith is supported by a research grant of the Research Foundation — Flanders (Belgium; FWO; Grant number: 1.5.217.13N) and is Senior Clinical Investigator of the Research Foundation — Flanders (Belgium; FWO). A.C. Trombetta, MD, PhD, Trainee in Clinical and Experimental Immunology, Research Laboratory and Academic Division of Clinical Rheumatology, Department of Internal Medicine, University of Genoa; C. Pizzorni, MD, PhD, Assistant Professor of Rheumatology, Research Laboratory and Academic Division of Clinical Rheumatology, Department of Internal Medicine, University of Genoa; B. Ruaro, MD, Trainee in Rheumatology, Research Laboratory and Academic Division of Clinical Rheumatology, Department of Internal Medicine, University of Genoa; S. Paolino, MD, Assistant Professor of Rheumatology, Research Laboratory and Academic Division of Clinical Rheumatology, Department of Internal Medicine, University of Genoa; A. Sulli, MD, Associate Professor of Rheumatology, Research Laboratory and Academic Division of Clinical Rheumatology, Department of Internal Medicine, University of Genoa; V. Smith, MD, PhD, Associate Professor of Rheumatology, Head of Clinics in Rheumatology, Ghent University Hospital, Ghent University; M. Cutolo, MD, Full Professor of Rheumatology, Research Laboratory and Academic Division of Clinical Rheumatology, Department of Internal Medicine, University of Genoa. Address correspondence to Dr. M. Cutolo, Research Laboratory and Academic Division of Clinical Rheumatology, Department of Internal Medicine, IRCCS San Martino AOU, University of Genoa, Viale Benedetto XV n. 6, 16132 Genoa, Italy. E-mail: mcutolo@unige.it. Full Release article. For details see Reprints/Permissions at jrheum.org. Accepted for publication August 25, 2016.
Barbara Ruaro
From the Research Laboratory and Academic Division of Clinical Rheumatology, Department of Internal Medicine, University of Genoa, Genoa, Italy; Department of Rheumatology, Ghent University Hospital, Ghent University, Ghent, Belgium. V. Smith is supported by a research grant of the Research Foundation — Flanders (Belgium; FWO; Grant number: 1.5.217.13N) and is Senior Clinical Investigator of the Research Foundation — Flanders (Belgium; FWO). A.C. Trombetta, MD, PhD, Trainee in Clinical and Experimental Immunology, Research Laboratory and Academic Division of Clinical Rheumatology, Department of Internal Medicine, University of Genoa; C. Pizzorni, MD, PhD, Assistant Professor of Rheumatology, Research Laboratory and Academic Division of Clinical Rheumatology, Department of Internal Medicine, University of Genoa; B. Ruaro, MD, Trainee in Rheumatology, Research Laboratory and Academic Division of Clinical Rheumatology, Department of Internal Medicine, University of Genoa; S. Paolino, MD, Assistant Professor of Rheumatology, Research Laboratory and Academic Division of Clinical Rheumatology, Department of Internal Medicine, University of Genoa; A. Sulli, MD, Associate Professor of Rheumatology, Research Laboratory and Academic Division of Clinical Rheumatology, Department of Internal Medicine, University of Genoa; V. Smith, MD, PhD, Associate Professor of Rheumatology, Head of Clinics in Rheumatology, Ghent University Hospital, Ghent University; M. Cutolo, MD, Full Professor of Rheumatology, Research Laboratory and Academic Division of Clinical Rheumatology, Department of Internal Medicine, University of Genoa. Address correspondence to Dr. M. Cutolo, Research Laboratory and Academic Division of Clinical Rheumatology, Department of Internal Medicine, IRCCS San Martino AOU, University of Genoa, Viale Benedetto XV n. 6, 16132 Genoa, Italy. E-mail: mcutolo@unige.it. Full Release article. For details see Reprints/Permissions at jrheum.org. Accepted for publication August 25, 2016.
Sabrina Paolino
From the Research Laboratory and Academic Division of Clinical Rheumatology, Department of Internal Medicine, University of Genoa, Genoa, Italy; Department of Rheumatology, Ghent University Hospital, Ghent University, Ghent, Belgium. V. Smith is supported by a research grant of the Research Foundation — Flanders (Belgium; FWO; Grant number: 1.5.217.13N) and is Senior Clinical Investigator of the Research Foundation — Flanders (Belgium; FWO). A.C. Trombetta, MD, PhD, Trainee in Clinical and Experimental Immunology, Research Laboratory and Academic Division of Clinical Rheumatology, Department of Internal Medicine, University of Genoa; C. Pizzorni, MD, PhD, Assistant Professor of Rheumatology, Research Laboratory and Academic Division of Clinical Rheumatology, Department of Internal Medicine, University of Genoa; B. Ruaro, MD, Trainee in Rheumatology, Research Laboratory and Academic Division of Clinical Rheumatology, Department of Internal Medicine, University of Genoa; S. Paolino, MD, Assistant Professor of Rheumatology, Research Laboratory and Academic Division of Clinical Rheumatology, Department of Internal Medicine, University of Genoa; A. Sulli, MD, Associate Professor of Rheumatology, Research Laboratory and Academic Division of Clinical Rheumatology, Department of Internal Medicine, University of Genoa; V. Smith, MD, PhD, Associate Professor of Rheumatology, Head of Clinics in Rheumatology, Ghent University Hospital, Ghent University; M. Cutolo, MD, Full Professor of Rheumatology, Research Laboratory and Academic Division of Clinical Rheumatology, Department of Internal Medicine, University of Genoa. Address correspondence to Dr. M. Cutolo, Research Laboratory and Academic Division of Clinical Rheumatology, Department of Internal Medicine, IRCCS San Martino AOU, University of Genoa, Viale Benedetto XV n. 6, 16132 Genoa, Italy. E-mail: mcutolo@unige.it. Full Release article. For details see Reprints/Permissions at jrheum.org. Accepted for publication August 25, 2016.
Alberto Sulli
From the Research Laboratory and Academic Division of Clinical Rheumatology, Department of Internal Medicine, University of Genoa, Genoa, Italy; Department of Rheumatology, Ghent University Hospital, Ghent University, Ghent, Belgium. V. Smith is supported by a research grant of the Research Foundation — Flanders (Belgium; FWO; Grant number: 1.5.217.13N) and is Senior Clinical Investigator of the Research Foundation — Flanders (Belgium; FWO). A.C. Trombetta, MD, PhD, Trainee in Clinical and Experimental Immunology, Research Laboratory and Academic Division of Clinical Rheumatology, Department of Internal Medicine, University of Genoa; C. Pizzorni, MD, PhD, Assistant Professor of Rheumatology, Research Laboratory and Academic Division of Clinical Rheumatology, Department of Internal Medicine, University of Genoa; B. Ruaro, MD, Trainee in Rheumatology, Research Laboratory and Academic Division of Clinical Rheumatology, Department of Internal Medicine, University of Genoa; S. Paolino, MD, Assistant Professor of Rheumatology, Research Laboratory and Academic Division of Clinical Rheumatology, Department of Internal Medicine, University of Genoa; A. Sulli, MD, Associate Professor of Rheumatology, Research Laboratory and Academic Division of Clinical Rheumatology, Department of Internal Medicine, University of Genoa; V. Smith, MD, PhD, Associate Professor of Rheumatology, Head of Clinics in Rheumatology, Ghent University Hospital, Ghent University; M. Cutolo, MD, Full Professor of Rheumatology, Research Laboratory and Academic Division of Clinical Rheumatology, Department of Internal Medicine, University of Genoa. Address correspondence to Dr. M. Cutolo, Research Laboratory and Academic Division of Clinical Rheumatology, Department of Internal Medicine, IRCCS San Martino AOU, University of Genoa, Viale Benedetto XV n. 6, 16132 Genoa, Italy. E-mail: mcutolo@unige.it. Full Release article. For details see Reprints/Permissions at jrheum.org. Accepted for publication August 25, 2016.
Vanessa Smith
From the Research Laboratory and Academic Division of Clinical Rheumatology, Department of Internal Medicine, University of Genoa, Genoa, Italy; Department of Rheumatology, Ghent University Hospital, Ghent University, Ghent, Belgium. V. Smith is supported by a research grant of the Research Foundation — Flanders (Belgium; FWO; Grant number: 1.5.217.13N) and is Senior Clinical Investigator of the Research Foundation — Flanders (Belgium; FWO). A.C. Trombetta, MD, PhD, Trainee in Clinical and Experimental Immunology, Research Laboratory and Academic Division of Clinical Rheumatology, Department of Internal Medicine, University of Genoa; C. Pizzorni, MD, PhD, Assistant Professor of Rheumatology, Research Laboratory and Academic Division of Clinical Rheumatology, Department of Internal Medicine, University of Genoa; B. Ruaro, MD, Trainee in Rheumatology, Research Laboratory and Academic Division of Clinical Rheumatology, Department of Internal Medicine, University of Genoa; S. Paolino, MD, Assistant Professor of Rheumatology, Research Laboratory and Academic Division of Clinical Rheumatology, Department of Internal Medicine, University of Genoa; A. Sulli, MD, Associate Professor of Rheumatology, Research Laboratory and Academic Division of Clinical Rheumatology, Department of Internal Medicine, University of Genoa; V. Smith, MD, PhD, Associate Professor of Rheumatology, Head of Clinics in Rheumatology, Ghent University Hospital, Ghent University; M. Cutolo, MD, Full Professor of Rheumatology, Research Laboratory and Academic Division of Clinical Rheumatology, Department of Internal Medicine, University of Genoa. Address correspondence to Dr. M. Cutolo, Research Laboratory and Academic Division of Clinical Rheumatology, Department of Internal Medicine, IRCCS San Martino AOU, University of Genoa, Viale Benedetto XV n. 6, 16132 Genoa, Italy. E-mail: mcutolo@unige.it. Full Release article. For details see Reprints/Permissions at jrheum.org. Accepted for publication August 25, 2016.
Maurizio Cutolo
From the Research Laboratory and Academic Division of Clinical Rheumatology, Department of Internal Medicine, University of Genoa, Genoa, Italy; Department of Rheumatology, Ghent University Hospital, Ghent University, Ghent, Belgium. V. Smith is supported by a research grant of the Research Foundation — Flanders (Belgium; FWO; Grant number: 1.5.217.13N) and is Senior Clinical Investigator of the Research Foundation — Flanders (Belgium; FWO). A.C. Trombetta, MD, PhD, Trainee in Clinical and Experimental Immunology, Research Laboratory and Academic Division of Clinical Rheumatology, Department of Internal Medicine, University of Genoa; C. Pizzorni, MD, PhD, Assistant Professor of Rheumatology, Research Laboratory and Academic Division of Clinical Rheumatology, Department of Internal Medicine, University of Genoa; B. Ruaro, MD, Trainee in Rheumatology, Research Laboratory and Academic Division of Clinical Rheumatology, Department of Internal Medicine, University of Genoa; S. Paolino, MD, Assistant Professor of Rheumatology, Research Laboratory and Academic Division of Clinical Rheumatology, Department of Internal Medicine, University of Genoa; A. Sulli, MD, Associate Professor of Rheumatology, Research Laboratory and Academic Division of Clinical Rheumatology, Department of Internal Medicine, University of Genoa; V. Smith, MD, PhD, Associate Professor of Rheumatology, Head of Clinics in Rheumatology, Ghent University Hospital, Ghent University; M. Cutolo, MD, Full Professor of Rheumatology, Research Laboratory and Academic Division of Clinical Rheumatology, Department of Internal Medicine, University of Genoa. Address correspondence to Dr. M. Cutolo, Research Laboratory and Academic Division of Clinical Rheumatology, Department of Internal Medicine, IRCCS San Martino AOU, University of Genoa, Viale Benedetto XV n. 6, 16132 Genoa, Italy. E-mail: mcutolo@unige.it. Full Release article. For details see Reprints/Permissions at jrheum.org. Accepted for publication August 25, 2016.
In this issue
The Journal of Rheumatology
Vol. 51, Issue 4
1 Apr 2024
Effects of Longterm Treatment with Bosentan and Iloprost on Nailfold Absolute Capillary Number, Fingertip Blood Perfusion, and Clinical Status in Systemic Sclerosis
Amelia Chiara Trombetta, Carmen Pizzorni, Barbara Ruaro, Sabrina Paolino, Alberto Sulli, Vanessa Smith, Maurizio Cutolo
The Journal of Rheumatology Oct 2016, jrheum.160592; DOI: 10.3899/jrheum.160592
Effects of Longterm Treatment with Bosentan and Iloprost on Nailfold Absolute Capillary Number, Fingertip Blood Perfusion, and Clinical Status in Systemic Sclerosis
Amelia Chiara Trombetta, Carmen Pizzorni, Barbara Ruaro, Sabrina Paolino, Alberto Sulli, Vanessa Smith, Maurizio Cutolo
The Journal of Rheumatology Oct 2016, jrheum.160592; DOI: 10.3899/jrheum.160592