Research ArticleArticle
Safety and Efficacy of SBI-087, a Subcutaneous Agent for B Cell Depletion, in Patients with Active Rheumatoid Arthritis: Results from a Phase II Randomized, Double-blind, Placebo-controlled Study
Nemanja Damjanov, Malgorzata Tlustochowicz, Jacob Aelion, Maria Greenwald, Annette Diehl, Indranil Bhattacharya, Elena Peeva, Sandeep Menon and Ian Gourley
The Journal of Rheumatology October 2016, jrheum.160146; DOI: https://doi.org/10.3899/jrheum.160146
Nemanja Damjanov
From Belgrade University School of Medicine, Belgrade, Serbia; Wojskowy Instytut Medyczny, Warsaw, Poland; Arthritis Clinic and West Tennessee Research Institute, Jackson, Tennessee; Desert Medical Advances, Palm Desert, California; Pfizer, Collegeville, Pennsylvania; Pfizer, Cambridge, Massachusetts; Janssen, Spring House, Pennsylvania, USA. Funded by Pfizer. Drs. Diehl, Bhattacharya, Peeva, and Menon are employees of Pfizer and own stock in Pfizer. Dr. Gourley is an employee of Janssen. N. Damjanov, MD, PhD, University of Belgrade School of Medicine; M. Tlustochowicz, MD, PhD, Wojskowy Instytut Medyczny; J. Aelion, MD, Arthritis Clinic and West Tennessee Research Institute; M. Greenwald, MD, Desert Medical Advances; A. Diehl, MPH, MBA, Pfizer; I. Bhattacharya, PhD, Pfizer; E. Peeva, MD, Pfizer; S. Menon, PhD, Pfizer; I. Gourley, MD, Janssen. Address correspondence to Dr. N. Damjanov, Rheumatology Department, Institute of Rheumatology, 11000 Belgrade, Resavska 69, Serbia. E-mail: nemanjadamjanov@yahoo.com. Accepted for publication August 25, 2016.
Malgorzata Tlustochowicz
From Belgrade University School of Medicine, Belgrade, Serbia; Wojskowy Instytut Medyczny, Warsaw, Poland; Arthritis Clinic and West Tennessee Research Institute, Jackson, Tennessee; Desert Medical Advances, Palm Desert, California; Pfizer, Collegeville, Pennsylvania; Pfizer, Cambridge, Massachusetts; Janssen, Spring House, Pennsylvania, USA. Funded by Pfizer. Drs. Diehl, Bhattacharya, Peeva, and Menon are employees of Pfizer and own stock in Pfizer. Dr. Gourley is an employee of Janssen. N. Damjanov, MD, PhD, University of Belgrade School of Medicine; M. Tlustochowicz, MD, PhD, Wojskowy Instytut Medyczny; J. Aelion, MD, Arthritis Clinic and West Tennessee Research Institute; M. Greenwald, MD, Desert Medical Advances; A. Diehl, MPH, MBA, Pfizer; I. Bhattacharya, PhD, Pfizer; E. Peeva, MD, Pfizer; S. Menon, PhD, Pfizer; I. Gourley, MD, Janssen. Address correspondence to Dr. N. Damjanov, Rheumatology Department, Institute of Rheumatology, 11000 Belgrade, Resavska 69, Serbia. E-mail: nemanjadamjanov@yahoo.com. Accepted for publication August 25, 2016.
Jacob Aelion
From Belgrade University School of Medicine, Belgrade, Serbia; Wojskowy Instytut Medyczny, Warsaw, Poland; Arthritis Clinic and West Tennessee Research Institute, Jackson, Tennessee; Desert Medical Advances, Palm Desert, California; Pfizer, Collegeville, Pennsylvania; Pfizer, Cambridge, Massachusetts; Janssen, Spring House, Pennsylvania, USA. Funded by Pfizer. Drs. Diehl, Bhattacharya, Peeva, and Menon are employees of Pfizer and own stock in Pfizer. Dr. Gourley is an employee of Janssen. N. Damjanov, MD, PhD, University of Belgrade School of Medicine; M. Tlustochowicz, MD, PhD, Wojskowy Instytut Medyczny; J. Aelion, MD, Arthritis Clinic and West Tennessee Research Institute; M. Greenwald, MD, Desert Medical Advances; A. Diehl, MPH, MBA, Pfizer; I. Bhattacharya, PhD, Pfizer; E. Peeva, MD, Pfizer; S. Menon, PhD, Pfizer; I. Gourley, MD, Janssen. Address correspondence to Dr. N. Damjanov, Rheumatology Department, Institute of Rheumatology, 11000 Belgrade, Resavska 69, Serbia. E-mail: nemanjadamjanov@yahoo.com. Accepted for publication August 25, 2016.
Maria Greenwald
From Belgrade University School of Medicine, Belgrade, Serbia; Wojskowy Instytut Medyczny, Warsaw, Poland; Arthritis Clinic and West Tennessee Research Institute, Jackson, Tennessee; Desert Medical Advances, Palm Desert, California; Pfizer, Collegeville, Pennsylvania; Pfizer, Cambridge, Massachusetts; Janssen, Spring House, Pennsylvania, USA. Funded by Pfizer. Drs. Diehl, Bhattacharya, Peeva, and Menon are employees of Pfizer and own stock in Pfizer. Dr. Gourley is an employee of Janssen. N. Damjanov, MD, PhD, University of Belgrade School of Medicine; M. Tlustochowicz, MD, PhD, Wojskowy Instytut Medyczny; J. Aelion, MD, Arthritis Clinic and West Tennessee Research Institute; M. Greenwald, MD, Desert Medical Advances; A. Diehl, MPH, MBA, Pfizer; I. Bhattacharya, PhD, Pfizer; E. Peeva, MD, Pfizer; S. Menon, PhD, Pfizer; I. Gourley, MD, Janssen. Address correspondence to Dr. N. Damjanov, Rheumatology Department, Institute of Rheumatology, 11000 Belgrade, Resavska 69, Serbia. E-mail: nemanjadamjanov@yahoo.com. Accepted for publication August 25, 2016.
Annette Diehl
From Belgrade University School of Medicine, Belgrade, Serbia; Wojskowy Instytut Medyczny, Warsaw, Poland; Arthritis Clinic and West Tennessee Research Institute, Jackson, Tennessee; Desert Medical Advances, Palm Desert, California; Pfizer, Collegeville, Pennsylvania; Pfizer, Cambridge, Massachusetts; Janssen, Spring House, Pennsylvania, USA. Funded by Pfizer. Drs. Diehl, Bhattacharya, Peeva, and Menon are employees of Pfizer and own stock in Pfizer. Dr. Gourley is an employee of Janssen. N. Damjanov, MD, PhD, University of Belgrade School of Medicine; M. Tlustochowicz, MD, PhD, Wojskowy Instytut Medyczny; J. Aelion, MD, Arthritis Clinic and West Tennessee Research Institute; M. Greenwald, MD, Desert Medical Advances; A. Diehl, MPH, MBA, Pfizer; I. Bhattacharya, PhD, Pfizer; E. Peeva, MD, Pfizer; S. Menon, PhD, Pfizer; I. Gourley, MD, Janssen. Address correspondence to Dr. N. Damjanov, Rheumatology Department, Institute of Rheumatology, 11000 Belgrade, Resavska 69, Serbia. E-mail: nemanjadamjanov@yahoo.com. Accepted for publication August 25, 2016.
Indranil Bhattacharya
From Belgrade University School of Medicine, Belgrade, Serbia; Wojskowy Instytut Medyczny, Warsaw, Poland; Arthritis Clinic and West Tennessee Research Institute, Jackson, Tennessee; Desert Medical Advances, Palm Desert, California; Pfizer, Collegeville, Pennsylvania; Pfizer, Cambridge, Massachusetts; Janssen, Spring House, Pennsylvania, USA. Funded by Pfizer. Drs. Diehl, Bhattacharya, Peeva, and Menon are employees of Pfizer and own stock in Pfizer. Dr. Gourley is an employee of Janssen. N. Damjanov, MD, PhD, University of Belgrade School of Medicine; M. Tlustochowicz, MD, PhD, Wojskowy Instytut Medyczny; J. Aelion, MD, Arthritis Clinic and West Tennessee Research Institute; M. Greenwald, MD, Desert Medical Advances; A. Diehl, MPH, MBA, Pfizer; I. Bhattacharya, PhD, Pfizer; E. Peeva, MD, Pfizer; S. Menon, PhD, Pfizer; I. Gourley, MD, Janssen. Address correspondence to Dr. N. Damjanov, Rheumatology Department, Institute of Rheumatology, 11000 Belgrade, Resavska 69, Serbia. E-mail: nemanjadamjanov@yahoo.com. Accepted for publication August 25, 2016.
Elena Peeva
From Belgrade University School of Medicine, Belgrade, Serbia; Wojskowy Instytut Medyczny, Warsaw, Poland; Arthritis Clinic and West Tennessee Research Institute, Jackson, Tennessee; Desert Medical Advances, Palm Desert, California; Pfizer, Collegeville, Pennsylvania; Pfizer, Cambridge, Massachusetts; Janssen, Spring House, Pennsylvania, USA. Funded by Pfizer. Drs. Diehl, Bhattacharya, Peeva, and Menon are employees of Pfizer and own stock in Pfizer. Dr. Gourley is an employee of Janssen. N. Damjanov, MD, PhD, University of Belgrade School of Medicine; M. Tlustochowicz, MD, PhD, Wojskowy Instytut Medyczny; J. Aelion, MD, Arthritis Clinic and West Tennessee Research Institute; M. Greenwald, MD, Desert Medical Advances; A. Diehl, MPH, MBA, Pfizer; I. Bhattacharya, PhD, Pfizer; E. Peeva, MD, Pfizer; S. Menon, PhD, Pfizer; I. Gourley, MD, Janssen. Address correspondence to Dr. N. Damjanov, Rheumatology Department, Institute of Rheumatology, 11000 Belgrade, Resavska 69, Serbia. E-mail: nemanjadamjanov@yahoo.com. Accepted for publication August 25, 2016.
Sandeep Menon
From Belgrade University School of Medicine, Belgrade, Serbia; Wojskowy Instytut Medyczny, Warsaw, Poland; Arthritis Clinic and West Tennessee Research Institute, Jackson, Tennessee; Desert Medical Advances, Palm Desert, California; Pfizer, Collegeville, Pennsylvania; Pfizer, Cambridge, Massachusetts; Janssen, Spring House, Pennsylvania, USA. Funded by Pfizer. Drs. Diehl, Bhattacharya, Peeva, and Menon are employees of Pfizer and own stock in Pfizer. Dr. Gourley is an employee of Janssen. N. Damjanov, MD, PhD, University of Belgrade School of Medicine; M. Tlustochowicz, MD, PhD, Wojskowy Instytut Medyczny; J. Aelion, MD, Arthritis Clinic and West Tennessee Research Institute; M. Greenwald, MD, Desert Medical Advances; A. Diehl, MPH, MBA, Pfizer; I. Bhattacharya, PhD, Pfizer; E. Peeva, MD, Pfizer; S. Menon, PhD, Pfizer; I. Gourley, MD, Janssen. Address correspondence to Dr. N. Damjanov, Rheumatology Department, Institute of Rheumatology, 11000 Belgrade, Resavska 69, Serbia. E-mail: nemanjadamjanov@yahoo.com. Accepted for publication August 25, 2016.
Ian Gourley
From Belgrade University School of Medicine, Belgrade, Serbia; Wojskowy Instytut Medyczny, Warsaw, Poland; Arthritis Clinic and West Tennessee Research Institute, Jackson, Tennessee; Desert Medical Advances, Palm Desert, California; Pfizer, Collegeville, Pennsylvania; Pfizer, Cambridge, Massachusetts; Janssen, Spring House, Pennsylvania, USA. Funded by Pfizer. Drs. Diehl, Bhattacharya, Peeva, and Menon are employees of Pfizer and own stock in Pfizer. Dr. Gourley is an employee of Janssen. N. Damjanov, MD, PhD, University of Belgrade School of Medicine; M. Tlustochowicz, MD, PhD, Wojskowy Instytut Medyczny; J. Aelion, MD, Arthritis Clinic and West Tennessee Research Institute; M. Greenwald, MD, Desert Medical Advances; A. Diehl, MPH, MBA, Pfizer; I. Bhattacharya, PhD, Pfizer; E. Peeva, MD, Pfizer; S. Menon, PhD, Pfizer; I. Gourley, MD, Janssen. Address correspondence to Dr. N. Damjanov, Rheumatology Department, Institute of Rheumatology, 11000 Belgrade, Resavska 69, Serbia. E-mail: nemanjadamjanov@yahoo.com. Accepted for publication August 25, 2016.
In this issue
The Journal of Rheumatology
Vol. 51, Issue 4
1 Apr 2024
Safety and Efficacy of SBI-087, a Subcutaneous Agent for B Cell Depletion, in Patients with Active Rheumatoid Arthritis: Results from a Phase II Randomized, Double-blind, Placebo-controlled Study
Nemanja Damjanov, Malgorzata Tlustochowicz, Jacob Aelion, Maria Greenwald, Annette Diehl, Indranil Bhattacharya, Elena Peeva, Sandeep Menon, Ian Gourley
The Journal of Rheumatology Oct 2016, jrheum.160146; DOI: 10.3899/jrheum.160146
Safety and Efficacy of SBI-087, a Subcutaneous Agent for B Cell Depletion, in Patients with Active Rheumatoid Arthritis: Results from a Phase II Randomized, Double-blind, Placebo-controlled Study
Nemanja Damjanov, Malgorzata Tlustochowicz, Jacob Aelion, Maria Greenwald, Annette Diehl, Indranil Bhattacharya, Elena Peeva, Sandeep Menon, Ian Gourley
The Journal of Rheumatology Oct 2016, jrheum.160146; DOI: 10.3899/jrheum.160146