Research ArticleArticle
Alarmin S100A9 Induces Proinflammatory and Catabolic Effects Predominantly in the M1 Macrophages of Human Osteoarthritic Synovium
Martijn H. van den Bosch, Arjen B. Blom, Rik F. Schelbergen, Marije I. Koenders, Fons A. van de Loo, Wim B. van den Berg, Thomas Vogl, Johannes Roth, Peter M. van der Kraan and Peter L. van Lent
The Journal of Rheumatology August 2016, jrheum.160270; DOI: https://doi.org/10.3899/jrheum.160270
Martijn H. van den Bosch
From Experimental Rheumatology, Radboud University Medical Center, Nijmegen, the Netherlands; Institute of Immunology, University of Münster, Münster, Germany. Financially supported by grants from the Dutch Arthritis Foundation (grant numbers 07-2-301 and 08-1-309). M.H. van den Bosch, MSc, Experimental Rheumatology, Radboud University Medical Center; A.B. Blom, PhD, Experimental Rheumatology, Radboud University Medical Center; R.F. Schelbergen, PhD, Experimental Rheumatology, Radboud University Medical Center; M.I. Koenders, PhD, Experimental Rheumatology, Radboud University Medical Center; F.A. van de Loo, PhD, Experimental Rheumatology, Radboud University Medical Center; W.B. van den Berg, PhD, Professor, Experimental Rheumatology, Radboud University Medical Center; T. Vogl, PhD, Professor, Institute of Immunology, University of Muenster; J. Roth, PhD, Professor, Institute of Immunology, University of Münster; P.M. van der Kraan, PhD, Experimental Rheumatology, Radboud University Medical Center; P.L. van Lent, PhD, Experimental Rheumatology, Radboud University Medical Center. Address correspondence to Dr. P.L. van Lent, Radboud University Medical Center, Geert Grooteplein 28, 6525 GA Nijmegen, the Netherlands. E-mail: peter.vanlent@radboudumc.nl. Accepted for publication June 27, 2016.
Arjen B. Blom
From Experimental Rheumatology, Radboud University Medical Center, Nijmegen, the Netherlands; Institute of Immunology, University of Münster, Münster, Germany. Financially supported by grants from the Dutch Arthritis Foundation (grant numbers 07-2-301 and 08-1-309). M.H. van den Bosch, MSc, Experimental Rheumatology, Radboud University Medical Center; A.B. Blom, PhD, Experimental Rheumatology, Radboud University Medical Center; R.F. Schelbergen, PhD, Experimental Rheumatology, Radboud University Medical Center; M.I. Koenders, PhD, Experimental Rheumatology, Radboud University Medical Center; F.A. van de Loo, PhD, Experimental Rheumatology, Radboud University Medical Center; W.B. van den Berg, PhD, Professor, Experimental Rheumatology, Radboud University Medical Center; T. Vogl, PhD, Professor, Institute of Immunology, University of Muenster; J. Roth, PhD, Professor, Institute of Immunology, University of Münster; P.M. van der Kraan, PhD, Experimental Rheumatology, Radboud University Medical Center; P.L. van Lent, PhD, Experimental Rheumatology, Radboud University Medical Center. Address correspondence to Dr. P.L. van Lent, Radboud University Medical Center, Geert Grooteplein 28, 6525 GA Nijmegen, the Netherlands. E-mail: peter.vanlent@radboudumc.nl. Accepted for publication June 27, 2016.
Rik F. Schelbergen
From Experimental Rheumatology, Radboud University Medical Center, Nijmegen, the Netherlands; Institute of Immunology, University of Münster, Münster, Germany. Financially supported by grants from the Dutch Arthritis Foundation (grant numbers 07-2-301 and 08-1-309). M.H. van den Bosch, MSc, Experimental Rheumatology, Radboud University Medical Center; A.B. Blom, PhD, Experimental Rheumatology, Radboud University Medical Center; R.F. Schelbergen, PhD, Experimental Rheumatology, Radboud University Medical Center; M.I. Koenders, PhD, Experimental Rheumatology, Radboud University Medical Center; F.A. van de Loo, PhD, Experimental Rheumatology, Radboud University Medical Center; W.B. van den Berg, PhD, Professor, Experimental Rheumatology, Radboud University Medical Center; T. Vogl, PhD, Professor, Institute of Immunology, University of Muenster; J. Roth, PhD, Professor, Institute of Immunology, University of Münster; P.M. van der Kraan, PhD, Experimental Rheumatology, Radboud University Medical Center; P.L. van Lent, PhD, Experimental Rheumatology, Radboud University Medical Center. Address correspondence to Dr. P.L. van Lent, Radboud University Medical Center, Geert Grooteplein 28, 6525 GA Nijmegen, the Netherlands. E-mail: peter.vanlent@radboudumc.nl. Accepted for publication June 27, 2016.
Marije I. Koenders
From Experimental Rheumatology, Radboud University Medical Center, Nijmegen, the Netherlands; Institute of Immunology, University of Münster, Münster, Germany. Financially supported by grants from the Dutch Arthritis Foundation (grant numbers 07-2-301 and 08-1-309). M.H. van den Bosch, MSc, Experimental Rheumatology, Radboud University Medical Center; A.B. Blom, PhD, Experimental Rheumatology, Radboud University Medical Center; R.F. Schelbergen, PhD, Experimental Rheumatology, Radboud University Medical Center; M.I. Koenders, PhD, Experimental Rheumatology, Radboud University Medical Center; F.A. van de Loo, PhD, Experimental Rheumatology, Radboud University Medical Center; W.B. van den Berg, PhD, Professor, Experimental Rheumatology, Radboud University Medical Center; T. Vogl, PhD, Professor, Institute of Immunology, University of Muenster; J. Roth, PhD, Professor, Institute of Immunology, University of Münster; P.M. van der Kraan, PhD, Experimental Rheumatology, Radboud University Medical Center; P.L. van Lent, PhD, Experimental Rheumatology, Radboud University Medical Center. Address correspondence to Dr. P.L. van Lent, Radboud University Medical Center, Geert Grooteplein 28, 6525 GA Nijmegen, the Netherlands. E-mail: peter.vanlent@radboudumc.nl. Accepted for publication June 27, 2016.
Fons A. van de Loo
From Experimental Rheumatology, Radboud University Medical Center, Nijmegen, the Netherlands; Institute of Immunology, University of Münster, Münster, Germany. Financially supported by grants from the Dutch Arthritis Foundation (grant numbers 07-2-301 and 08-1-309). M.H. van den Bosch, MSc, Experimental Rheumatology, Radboud University Medical Center; A.B. Blom, PhD, Experimental Rheumatology, Radboud University Medical Center; R.F. Schelbergen, PhD, Experimental Rheumatology, Radboud University Medical Center; M.I. Koenders, PhD, Experimental Rheumatology, Radboud University Medical Center; F.A. van de Loo, PhD, Experimental Rheumatology, Radboud University Medical Center; W.B. van den Berg, PhD, Professor, Experimental Rheumatology, Radboud University Medical Center; T. Vogl, PhD, Professor, Institute of Immunology, University of Muenster; J. Roth, PhD, Professor, Institute of Immunology, University of Münster; P.M. van der Kraan, PhD, Experimental Rheumatology, Radboud University Medical Center; P.L. van Lent, PhD, Experimental Rheumatology, Radboud University Medical Center. Address correspondence to Dr. P.L. van Lent, Radboud University Medical Center, Geert Grooteplein 28, 6525 GA Nijmegen, the Netherlands. E-mail: peter.vanlent@radboudumc.nl. Accepted for publication June 27, 2016.
Wim B. van den Berg
From Experimental Rheumatology, Radboud University Medical Center, Nijmegen, the Netherlands; Institute of Immunology, University of Münster, Münster, Germany. Financially supported by grants from the Dutch Arthritis Foundation (grant numbers 07-2-301 and 08-1-309). M.H. van den Bosch, MSc, Experimental Rheumatology, Radboud University Medical Center; A.B. Blom, PhD, Experimental Rheumatology, Radboud University Medical Center; R.F. Schelbergen, PhD, Experimental Rheumatology, Radboud University Medical Center; M.I. Koenders, PhD, Experimental Rheumatology, Radboud University Medical Center; F.A. van de Loo, PhD, Experimental Rheumatology, Radboud University Medical Center; W.B. van den Berg, PhD, Professor, Experimental Rheumatology, Radboud University Medical Center; T. Vogl, PhD, Professor, Institute of Immunology, University of Muenster; J. Roth, PhD, Professor, Institute of Immunology, University of Münster; P.M. van der Kraan, PhD, Experimental Rheumatology, Radboud University Medical Center; P.L. van Lent, PhD, Experimental Rheumatology, Radboud University Medical Center. Address correspondence to Dr. P.L. van Lent, Radboud University Medical Center, Geert Grooteplein 28, 6525 GA Nijmegen, the Netherlands. E-mail: peter.vanlent@radboudumc.nl. Accepted for publication June 27, 2016.
Thomas Vogl
From Experimental Rheumatology, Radboud University Medical Center, Nijmegen, the Netherlands; Institute of Immunology, University of Münster, Münster, Germany. Financially supported by grants from the Dutch Arthritis Foundation (grant numbers 07-2-301 and 08-1-309). M.H. van den Bosch, MSc, Experimental Rheumatology, Radboud University Medical Center; A.B. Blom, PhD, Experimental Rheumatology, Radboud University Medical Center; R.F. Schelbergen, PhD, Experimental Rheumatology, Radboud University Medical Center; M.I. Koenders, PhD, Experimental Rheumatology, Radboud University Medical Center; F.A. van de Loo, PhD, Experimental Rheumatology, Radboud University Medical Center; W.B. van den Berg, PhD, Professor, Experimental Rheumatology, Radboud University Medical Center; T. Vogl, PhD, Professor, Institute of Immunology, University of Muenster; J. Roth, PhD, Professor, Institute of Immunology, University of Münster; P.M. van der Kraan, PhD, Experimental Rheumatology, Radboud University Medical Center; P.L. van Lent, PhD, Experimental Rheumatology, Radboud University Medical Center. Address correspondence to Dr. P.L. van Lent, Radboud University Medical Center, Geert Grooteplein 28, 6525 GA Nijmegen, the Netherlands. E-mail: peter.vanlent@radboudumc.nl. Accepted for publication June 27, 2016.
Johannes Roth
From Experimental Rheumatology, Radboud University Medical Center, Nijmegen, the Netherlands; Institute of Immunology, University of Münster, Münster, Germany. Financially supported by grants from the Dutch Arthritis Foundation (grant numbers 07-2-301 and 08-1-309). M.H. van den Bosch, MSc, Experimental Rheumatology, Radboud University Medical Center; A.B. Blom, PhD, Experimental Rheumatology, Radboud University Medical Center; R.F. Schelbergen, PhD, Experimental Rheumatology, Radboud University Medical Center; M.I. Koenders, PhD, Experimental Rheumatology, Radboud University Medical Center; F.A. van de Loo, PhD, Experimental Rheumatology, Radboud University Medical Center; W.B. van den Berg, PhD, Professor, Experimental Rheumatology, Radboud University Medical Center; T. Vogl, PhD, Professor, Institute of Immunology, University of Muenster; J. Roth, PhD, Professor, Institute of Immunology, University of Münster; P.M. van der Kraan, PhD, Experimental Rheumatology, Radboud University Medical Center; P.L. van Lent, PhD, Experimental Rheumatology, Radboud University Medical Center. Address correspondence to Dr. P.L. van Lent, Radboud University Medical Center, Geert Grooteplein 28, 6525 GA Nijmegen, the Netherlands. E-mail: peter.vanlent@radboudumc.nl. Accepted for publication June 27, 2016.
Peter M. van der Kraan
From Experimental Rheumatology, Radboud University Medical Center, Nijmegen, the Netherlands; Institute of Immunology, University of Münster, Münster, Germany. Financially supported by grants from the Dutch Arthritis Foundation (grant numbers 07-2-301 and 08-1-309). M.H. van den Bosch, MSc, Experimental Rheumatology, Radboud University Medical Center; A.B. Blom, PhD, Experimental Rheumatology, Radboud University Medical Center; R.F. Schelbergen, PhD, Experimental Rheumatology, Radboud University Medical Center; M.I. Koenders, PhD, Experimental Rheumatology, Radboud University Medical Center; F.A. van de Loo, PhD, Experimental Rheumatology, Radboud University Medical Center; W.B. van den Berg, PhD, Professor, Experimental Rheumatology, Radboud University Medical Center; T. Vogl, PhD, Professor, Institute of Immunology, University of Muenster; J. Roth, PhD, Professor, Institute of Immunology, University of Münster; P.M. van der Kraan, PhD, Experimental Rheumatology, Radboud University Medical Center; P.L. van Lent, PhD, Experimental Rheumatology, Radboud University Medical Center. Address correspondence to Dr. P.L. van Lent, Radboud University Medical Center, Geert Grooteplein 28, 6525 GA Nijmegen, the Netherlands. E-mail: peter.vanlent@radboudumc.nl. Accepted for publication June 27, 2016.
Peter L. van Lent
From Experimental Rheumatology, Radboud University Medical Center, Nijmegen, the Netherlands; Institute of Immunology, University of Münster, Münster, Germany. Financially supported by grants from the Dutch Arthritis Foundation (grant numbers 07-2-301 and 08-1-309). M.H. van den Bosch, MSc, Experimental Rheumatology, Radboud University Medical Center; A.B. Blom, PhD, Experimental Rheumatology, Radboud University Medical Center; R.F. Schelbergen, PhD, Experimental Rheumatology, Radboud University Medical Center; M.I. Koenders, PhD, Experimental Rheumatology, Radboud University Medical Center; F.A. van de Loo, PhD, Experimental Rheumatology, Radboud University Medical Center; W.B. van den Berg, PhD, Professor, Experimental Rheumatology, Radboud University Medical Center; T. Vogl, PhD, Professor, Institute of Immunology, University of Muenster; J. Roth, PhD, Professor, Institute of Immunology, University of Münster; P.M. van der Kraan, PhD, Experimental Rheumatology, Radboud University Medical Center; P.L. van Lent, PhD, Experimental Rheumatology, Radboud University Medical Center. Address correspondence to Dr. P.L. van Lent, Radboud University Medical Center, Geert Grooteplein 28, 6525 GA Nijmegen, the Netherlands. E-mail: peter.vanlent@radboudumc.nl. Accepted for publication June 27, 2016.
In this issue
The Journal of Rheumatology
Vol. 51, Issue 4
1 Apr 2024
Alarmin S100A9 Induces Proinflammatory and Catabolic Effects Predominantly in the M1 Macrophages of Human Osteoarthritic Synovium
Martijn H. van den Bosch, Arjen B. Blom, Rik F. Schelbergen, Marije I. Koenders, Fons A. van de Loo, Wim B. van den Berg, Thomas Vogl, Johannes Roth, Peter M. van der Kraan, Peter L. van Lent
The Journal of Rheumatology Aug 2016, jrheum.160270; DOI: 10.3899/jrheum.160270
Alarmin S100A9 Induces Proinflammatory and Catabolic Effects Predominantly in the M1 Macrophages of Human Osteoarthritic Synovium
Martijn H. van den Bosch, Arjen B. Blom, Rik F. Schelbergen, Marije I. Koenders, Fons A. van de Loo, Wim B. van den Berg, Thomas Vogl, Johannes Roth, Peter M. van der Kraan, Peter L. van Lent
The Journal of Rheumatology Aug 2016, jrheum.160270; DOI: 10.3899/jrheum.160270