Research ArticleArticle
Longterm Retention Rate and Risk Factors for Adalimumab Discontinuation Due To Efficacy and Safety in Japanese Patients with Rheumatoid Arthritis: An Observational Cohort Study
Yosuke Hattori, Toshihisa Kojima, Atsushi Kaneko, Daihei Kida, Yuji Hirano, Takayoshi Fujibayashi, Kenya Terabe, Yuichiro Yabe, Hiroyuki Miyake, Takefumi Kato, Hideki Takagi, Masatoshi Hayashi, Takayasu Ito, Yasuhide Kanayama, Takeshi Oguchi, Nobunori Takahashi, Hisato Ishikawa, Koji Funahashi and Naoki Ishiguro
The Journal of Rheumatology June 2016, jrheum.151006; DOI: https://doi.org/10.3899/jrheum.151006
Yosuke Hattori
From the National Hospital Organization Nagoya Medical Center, Orthopedic Surgery and Rheumatology; Orthopedic Surgery, Nagoya University Graduate School of Medicine; Orthopedic Surgery, Nagoya Central Hospital; Ito Seikeigeka; Orthopedic Surgery and Rheumatology, Toyota Kosei Hospital; Orthopedic Surgery, Japanese Red Cross Nagoya Daiichi Hospital, Nagoya; Rheumatology, Toyohashi Municipal Hospital, Toyohashi; Orthopedic Surgery, Konan Kosei Hospital, Konan; Rheumatology, Japan Community Healthcare Organization Tokyo Shinjuku Medical Center, Tokyo; Orthopedic Surgery, Ichinomiya Municipal Hospital, Ichinomiya; Kato Clinic, Okazaki; Rheumatology, Nagano Red Cross Hospital, Nagano; Orthopedic Surgery, Anjo Kosei Hospital, Anjo, Japan. Y. Hattori, MD, PhD, Orthopedic Surgery and Rheumatology, National Hospital Organization Nagoya Medical Center; T. Kojima, MD, PhD, Department of Orthopedic Surgery, School of Medicine, Nagoya University; A. Kaneko, MD, Orthopedic Surgery and Rheumatology, National Hospital Organization Nagoya Medical Center; D. Kida, MD, PhD, Orthopedic Surgery and Rheumatology, National Hospital Organization Nagoya Medical Center; Y. Hirano, MD, PhD, Rheumatology Toyohashi Municipal Hospital; T. Fujibayashi, MD, PhD, Orthopedic Surgery, Konan Kosei Hospital; K. Terabe, MD, PhD, Orthopedic Surgery, Nagoya University Graduate School of Medicine; Y. Yabe, MD, PhD, Rheumatology, Japan Community Healthcare Organization Tokyo Shinjuku Medical Center; H. Miyake, MD, PhD, Orthopedic Surgery, Ichinomiya Municipal Hospital; T. Kato, MD, PhD, Kato Clinic; H. Takagi, MD, PhD, Orthopedic Surgery, Nagoya Central Hospital; M. Hayashi, MD, PhD, Rheumatology, Nagano Red Cross Hospital; T. Ito, MD, PhD, Ito Seikeigeka; Y. Kanayama, MD, PhD, Orthopedic Surgery and Rheumatology, Toyota Kosei Hospital; T. Oguchi, MD, PhD, Orthopedic Surgery, Anjo Kosei Hospital; N. Takahashi, MD, PhD, Orthopedic Surgery, Nagoya University Graduate School of Medicine; H. Ishikawa, MD, PhD, Orthopedic Surgery, Japanese Red Cross Nagoya Daiichi Hospital; K. Funahashi, MD, PhD, Orthopedic Surgery, Nagoya University Graduate School of Medicine; N. Ishiguro, MD, PhD, Orthopedic Surgery, Nagoya University Graduate School of Medicine. Address correspondence to Dr. Y. Hattori, National Hospital Organization Nagoya Medical Center, Orthopedic Surgery and Rheumatology, 4-1-1 Sannomaru, Naka-ku, Nagoya, Aichi 460-000, Japan. E-mail: yosuke-h@med.nagoya-u.ac.jp. Accepted for publication April 27, 2016.
Toshihisa Kojima
From the National Hospital Organization Nagoya Medical Center, Orthopedic Surgery and Rheumatology; Orthopedic Surgery, Nagoya University Graduate School of Medicine; Orthopedic Surgery, Nagoya Central Hospital; Ito Seikeigeka; Orthopedic Surgery and Rheumatology, Toyota Kosei Hospital; Orthopedic Surgery, Japanese Red Cross Nagoya Daiichi Hospital, Nagoya; Rheumatology, Toyohashi Municipal Hospital, Toyohashi; Orthopedic Surgery, Konan Kosei Hospital, Konan; Rheumatology, Japan Community Healthcare Organization Tokyo Shinjuku Medical Center, Tokyo; Orthopedic Surgery, Ichinomiya Municipal Hospital, Ichinomiya; Kato Clinic, Okazaki; Rheumatology, Nagano Red Cross Hospital, Nagano; Orthopedic Surgery, Anjo Kosei Hospital, Anjo, Japan. Y. Hattori, MD, PhD, Orthopedic Surgery and Rheumatology, National Hospital Organization Nagoya Medical Center; T. Kojima, MD, PhD, Department of Orthopedic Surgery, School of Medicine, Nagoya University; A. Kaneko, MD, Orthopedic Surgery and Rheumatology, National Hospital Organization Nagoya Medical Center; D. Kida, MD, PhD, Orthopedic Surgery and Rheumatology, National Hospital Organization Nagoya Medical Center; Y. Hirano, MD, PhD, Rheumatology Toyohashi Municipal Hospital; T. Fujibayashi, MD, PhD, Orthopedic Surgery, Konan Kosei Hospital; K. Terabe, MD, PhD, Orthopedic Surgery, Nagoya University Graduate School of Medicine; Y. Yabe, MD, PhD, Rheumatology, Japan Community Healthcare Organization Tokyo Shinjuku Medical Center; H. Miyake, MD, PhD, Orthopedic Surgery, Ichinomiya Municipal Hospital; T. Kato, MD, PhD, Kato Clinic; H. Takagi, MD, PhD, Orthopedic Surgery, Nagoya Central Hospital; M. Hayashi, MD, PhD, Rheumatology, Nagano Red Cross Hospital; T. Ito, MD, PhD, Ito Seikeigeka; Y. Kanayama, MD, PhD, Orthopedic Surgery and Rheumatology, Toyota Kosei Hospital; T. Oguchi, MD, PhD, Orthopedic Surgery, Anjo Kosei Hospital; N. Takahashi, MD, PhD, Orthopedic Surgery, Nagoya University Graduate School of Medicine; H. Ishikawa, MD, PhD, Orthopedic Surgery, Japanese Red Cross Nagoya Daiichi Hospital; K. Funahashi, MD, PhD, Orthopedic Surgery, Nagoya University Graduate School of Medicine; N. Ishiguro, MD, PhD, Orthopedic Surgery, Nagoya University Graduate School of Medicine. Address correspondence to Dr. Y. Hattori, National Hospital Organization Nagoya Medical Center, Orthopedic Surgery and Rheumatology, 4-1-1 Sannomaru, Naka-ku, Nagoya, Aichi 460-000, Japan. E-mail: yosuke-h@med.nagoya-u.ac.jp. Accepted for publication April 27, 2016.
Atsushi Kaneko
From the National Hospital Organization Nagoya Medical Center, Orthopedic Surgery and Rheumatology; Orthopedic Surgery, Nagoya University Graduate School of Medicine; Orthopedic Surgery, Nagoya Central Hospital; Ito Seikeigeka; Orthopedic Surgery and Rheumatology, Toyota Kosei Hospital; Orthopedic Surgery, Japanese Red Cross Nagoya Daiichi Hospital, Nagoya; Rheumatology, Toyohashi Municipal Hospital, Toyohashi; Orthopedic Surgery, Konan Kosei Hospital, Konan; Rheumatology, Japan Community Healthcare Organization Tokyo Shinjuku Medical Center, Tokyo; Orthopedic Surgery, Ichinomiya Municipal Hospital, Ichinomiya; Kato Clinic, Okazaki; Rheumatology, Nagano Red Cross Hospital, Nagano; Orthopedic Surgery, Anjo Kosei Hospital, Anjo, Japan. Y. Hattori, MD, PhD, Orthopedic Surgery and Rheumatology, National Hospital Organization Nagoya Medical Center; T. Kojima, MD, PhD, Department of Orthopedic Surgery, School of Medicine, Nagoya University; A. Kaneko, MD, Orthopedic Surgery and Rheumatology, National Hospital Organization Nagoya Medical Center; D. Kida, MD, PhD, Orthopedic Surgery and Rheumatology, National Hospital Organization Nagoya Medical Center; Y. Hirano, MD, PhD, Rheumatology Toyohashi Municipal Hospital; T. Fujibayashi, MD, PhD, Orthopedic Surgery, Konan Kosei Hospital; K. Terabe, MD, PhD, Orthopedic Surgery, Nagoya University Graduate School of Medicine; Y. Yabe, MD, PhD, Rheumatology, Japan Community Healthcare Organization Tokyo Shinjuku Medical Center; H. Miyake, MD, PhD, Orthopedic Surgery, Ichinomiya Municipal Hospital; T. Kato, MD, PhD, Kato Clinic; H. Takagi, MD, PhD, Orthopedic Surgery, Nagoya Central Hospital; M. Hayashi, MD, PhD, Rheumatology, Nagano Red Cross Hospital; T. Ito, MD, PhD, Ito Seikeigeka; Y. Kanayama, MD, PhD, Orthopedic Surgery and Rheumatology, Toyota Kosei Hospital; T. Oguchi, MD, PhD, Orthopedic Surgery, Anjo Kosei Hospital; N. Takahashi, MD, PhD, Orthopedic Surgery, Nagoya University Graduate School of Medicine; H. Ishikawa, MD, PhD, Orthopedic Surgery, Japanese Red Cross Nagoya Daiichi Hospital; K. Funahashi, MD, PhD, Orthopedic Surgery, Nagoya University Graduate School of Medicine; N. Ishiguro, MD, PhD, Orthopedic Surgery, Nagoya University Graduate School of Medicine. Address correspondence to Dr. Y. Hattori, National Hospital Organization Nagoya Medical Center, Orthopedic Surgery and Rheumatology, 4-1-1 Sannomaru, Naka-ku, Nagoya, Aichi 460-000, Japan. E-mail: yosuke-h@med.nagoya-u.ac.jp. Accepted for publication April 27, 2016.
Daihei Kida
From the National Hospital Organization Nagoya Medical Center, Orthopedic Surgery and Rheumatology; Orthopedic Surgery, Nagoya University Graduate School of Medicine; Orthopedic Surgery, Nagoya Central Hospital; Ito Seikeigeka; Orthopedic Surgery and Rheumatology, Toyota Kosei Hospital; Orthopedic Surgery, Japanese Red Cross Nagoya Daiichi Hospital, Nagoya; Rheumatology, Toyohashi Municipal Hospital, Toyohashi; Orthopedic Surgery, Konan Kosei Hospital, Konan; Rheumatology, Japan Community Healthcare Organization Tokyo Shinjuku Medical Center, Tokyo; Orthopedic Surgery, Ichinomiya Municipal Hospital, Ichinomiya; Kato Clinic, Okazaki; Rheumatology, Nagano Red Cross Hospital, Nagano; Orthopedic Surgery, Anjo Kosei Hospital, Anjo, Japan. Y. Hattori, MD, PhD, Orthopedic Surgery and Rheumatology, National Hospital Organization Nagoya Medical Center; T. Kojima, MD, PhD, Department of Orthopedic Surgery, School of Medicine, Nagoya University; A. Kaneko, MD, Orthopedic Surgery and Rheumatology, National Hospital Organization Nagoya Medical Center; D. Kida, MD, PhD, Orthopedic Surgery and Rheumatology, National Hospital Organization Nagoya Medical Center; Y. Hirano, MD, PhD, Rheumatology Toyohashi Municipal Hospital; T. Fujibayashi, MD, PhD, Orthopedic Surgery, Konan Kosei Hospital; K. Terabe, MD, PhD, Orthopedic Surgery, Nagoya University Graduate School of Medicine; Y. Yabe, MD, PhD, Rheumatology, Japan Community Healthcare Organization Tokyo Shinjuku Medical Center; H. Miyake, MD, PhD, Orthopedic Surgery, Ichinomiya Municipal Hospital; T. Kato, MD, PhD, Kato Clinic; H. Takagi, MD, PhD, Orthopedic Surgery, Nagoya Central Hospital; M. Hayashi, MD, PhD, Rheumatology, Nagano Red Cross Hospital; T. Ito, MD, PhD, Ito Seikeigeka; Y. Kanayama, MD, PhD, Orthopedic Surgery and Rheumatology, Toyota Kosei Hospital; T. Oguchi, MD, PhD, Orthopedic Surgery, Anjo Kosei Hospital; N. Takahashi, MD, PhD, Orthopedic Surgery, Nagoya University Graduate School of Medicine; H. Ishikawa, MD, PhD, Orthopedic Surgery, Japanese Red Cross Nagoya Daiichi Hospital; K. Funahashi, MD, PhD, Orthopedic Surgery, Nagoya University Graduate School of Medicine; N. Ishiguro, MD, PhD, Orthopedic Surgery, Nagoya University Graduate School of Medicine. Address correspondence to Dr. Y. Hattori, National Hospital Organization Nagoya Medical Center, Orthopedic Surgery and Rheumatology, 4-1-1 Sannomaru, Naka-ku, Nagoya, Aichi 460-000, Japan. E-mail: yosuke-h@med.nagoya-u.ac.jp. Accepted for publication April 27, 2016.
Yuji Hirano
From the National Hospital Organization Nagoya Medical Center, Orthopedic Surgery and Rheumatology; Orthopedic Surgery, Nagoya University Graduate School of Medicine; Orthopedic Surgery, Nagoya Central Hospital; Ito Seikeigeka; Orthopedic Surgery and Rheumatology, Toyota Kosei Hospital; Orthopedic Surgery, Japanese Red Cross Nagoya Daiichi Hospital, Nagoya; Rheumatology, Toyohashi Municipal Hospital, Toyohashi; Orthopedic Surgery, Konan Kosei Hospital, Konan; Rheumatology, Japan Community Healthcare Organization Tokyo Shinjuku Medical Center, Tokyo; Orthopedic Surgery, Ichinomiya Municipal Hospital, Ichinomiya; Kato Clinic, Okazaki; Rheumatology, Nagano Red Cross Hospital, Nagano; Orthopedic Surgery, Anjo Kosei Hospital, Anjo, Japan. Y. Hattori, MD, PhD, Orthopedic Surgery and Rheumatology, National Hospital Organization Nagoya Medical Center; T. Kojima, MD, PhD, Department of Orthopedic Surgery, School of Medicine, Nagoya University; A. Kaneko, MD, Orthopedic Surgery and Rheumatology, National Hospital Organization Nagoya Medical Center; D. Kida, MD, PhD, Orthopedic Surgery and Rheumatology, National Hospital Organization Nagoya Medical Center; Y. Hirano, MD, PhD, Rheumatology Toyohashi Municipal Hospital; T. Fujibayashi, MD, PhD, Orthopedic Surgery, Konan Kosei Hospital; K. Terabe, MD, PhD, Orthopedic Surgery, Nagoya University Graduate School of Medicine; Y. Yabe, MD, PhD, Rheumatology, Japan Community Healthcare Organization Tokyo Shinjuku Medical Center; H. Miyake, MD, PhD, Orthopedic Surgery, Ichinomiya Municipal Hospital; T. Kato, MD, PhD, Kato Clinic; H. Takagi, MD, PhD, Orthopedic Surgery, Nagoya Central Hospital; M. Hayashi, MD, PhD, Rheumatology, Nagano Red Cross Hospital; T. Ito, MD, PhD, Ito Seikeigeka; Y. Kanayama, MD, PhD, Orthopedic Surgery and Rheumatology, Toyota Kosei Hospital; T. Oguchi, MD, PhD, Orthopedic Surgery, Anjo Kosei Hospital; N. Takahashi, MD, PhD, Orthopedic Surgery, Nagoya University Graduate School of Medicine; H. Ishikawa, MD, PhD, Orthopedic Surgery, Japanese Red Cross Nagoya Daiichi Hospital; K. Funahashi, MD, PhD, Orthopedic Surgery, Nagoya University Graduate School of Medicine; N. Ishiguro, MD, PhD, Orthopedic Surgery, Nagoya University Graduate School of Medicine. Address correspondence to Dr. Y. Hattori, National Hospital Organization Nagoya Medical Center, Orthopedic Surgery and Rheumatology, 4-1-1 Sannomaru, Naka-ku, Nagoya, Aichi 460-000, Japan. E-mail: yosuke-h@med.nagoya-u.ac.jp. Accepted for publication April 27, 2016.
Takayoshi Fujibayashi
From the National Hospital Organization Nagoya Medical Center, Orthopedic Surgery and Rheumatology; Orthopedic Surgery, Nagoya University Graduate School of Medicine; Orthopedic Surgery, Nagoya Central Hospital; Ito Seikeigeka; Orthopedic Surgery and Rheumatology, Toyota Kosei Hospital; Orthopedic Surgery, Japanese Red Cross Nagoya Daiichi Hospital, Nagoya; Rheumatology, Toyohashi Municipal Hospital, Toyohashi; Orthopedic Surgery, Konan Kosei Hospital, Konan; Rheumatology, Japan Community Healthcare Organization Tokyo Shinjuku Medical Center, Tokyo; Orthopedic Surgery, Ichinomiya Municipal Hospital, Ichinomiya; Kato Clinic, Okazaki; Rheumatology, Nagano Red Cross Hospital, Nagano; Orthopedic Surgery, Anjo Kosei Hospital, Anjo, Japan. Y. Hattori, MD, PhD, Orthopedic Surgery and Rheumatology, National Hospital Organization Nagoya Medical Center; T. Kojima, MD, PhD, Department of Orthopedic Surgery, School of Medicine, Nagoya University; A. Kaneko, MD, Orthopedic Surgery and Rheumatology, National Hospital Organization Nagoya Medical Center; D. Kida, MD, PhD, Orthopedic Surgery and Rheumatology, National Hospital Organization Nagoya Medical Center; Y. Hirano, MD, PhD, Rheumatology Toyohashi Municipal Hospital; T. Fujibayashi, MD, PhD, Orthopedic Surgery, Konan Kosei Hospital; K. Terabe, MD, PhD, Orthopedic Surgery, Nagoya University Graduate School of Medicine; Y. Yabe, MD, PhD, Rheumatology, Japan Community Healthcare Organization Tokyo Shinjuku Medical Center; H. Miyake, MD, PhD, Orthopedic Surgery, Ichinomiya Municipal Hospital; T. Kato, MD, PhD, Kato Clinic; H. Takagi, MD, PhD, Orthopedic Surgery, Nagoya Central Hospital; M. Hayashi, MD, PhD, Rheumatology, Nagano Red Cross Hospital; T. Ito, MD, PhD, Ito Seikeigeka; Y. Kanayama, MD, PhD, Orthopedic Surgery and Rheumatology, Toyota Kosei Hospital; T. Oguchi, MD, PhD, Orthopedic Surgery, Anjo Kosei Hospital; N. Takahashi, MD, PhD, Orthopedic Surgery, Nagoya University Graduate School of Medicine; H. Ishikawa, MD, PhD, Orthopedic Surgery, Japanese Red Cross Nagoya Daiichi Hospital; K. Funahashi, MD, PhD, Orthopedic Surgery, Nagoya University Graduate School of Medicine; N. Ishiguro, MD, PhD, Orthopedic Surgery, Nagoya University Graduate School of Medicine. Address correspondence to Dr. Y. Hattori, National Hospital Organization Nagoya Medical Center, Orthopedic Surgery and Rheumatology, 4-1-1 Sannomaru, Naka-ku, Nagoya, Aichi 460-000, Japan. E-mail: yosuke-h@med.nagoya-u.ac.jp. Accepted for publication April 27, 2016.
Kenya Terabe
From the National Hospital Organization Nagoya Medical Center, Orthopedic Surgery and Rheumatology; Orthopedic Surgery, Nagoya University Graduate School of Medicine; Orthopedic Surgery, Nagoya Central Hospital; Ito Seikeigeka; Orthopedic Surgery and Rheumatology, Toyota Kosei Hospital; Orthopedic Surgery, Japanese Red Cross Nagoya Daiichi Hospital, Nagoya; Rheumatology, Toyohashi Municipal Hospital, Toyohashi; Orthopedic Surgery, Konan Kosei Hospital, Konan; Rheumatology, Japan Community Healthcare Organization Tokyo Shinjuku Medical Center, Tokyo; Orthopedic Surgery, Ichinomiya Municipal Hospital, Ichinomiya; Kato Clinic, Okazaki; Rheumatology, Nagano Red Cross Hospital, Nagano; Orthopedic Surgery, Anjo Kosei Hospital, Anjo, Japan. Y. Hattori, MD, PhD, Orthopedic Surgery and Rheumatology, National Hospital Organization Nagoya Medical Center; T. Kojima, MD, PhD, Department of Orthopedic Surgery, School of Medicine, Nagoya University; A. Kaneko, MD, Orthopedic Surgery and Rheumatology, National Hospital Organization Nagoya Medical Center; D. Kida, MD, PhD, Orthopedic Surgery and Rheumatology, National Hospital Organization Nagoya Medical Center; Y. Hirano, MD, PhD, Rheumatology Toyohashi Municipal Hospital; T. Fujibayashi, MD, PhD, Orthopedic Surgery, Konan Kosei Hospital; K. Terabe, MD, PhD, Orthopedic Surgery, Nagoya University Graduate School of Medicine; Y. Yabe, MD, PhD, Rheumatology, Japan Community Healthcare Organization Tokyo Shinjuku Medical Center; H. Miyake, MD, PhD, Orthopedic Surgery, Ichinomiya Municipal Hospital; T. Kato, MD, PhD, Kato Clinic; H. Takagi, MD, PhD, Orthopedic Surgery, Nagoya Central Hospital; M. Hayashi, MD, PhD, Rheumatology, Nagano Red Cross Hospital; T. Ito, MD, PhD, Ito Seikeigeka; Y. Kanayama, MD, PhD, Orthopedic Surgery and Rheumatology, Toyota Kosei Hospital; T. Oguchi, MD, PhD, Orthopedic Surgery, Anjo Kosei Hospital; N. Takahashi, MD, PhD, Orthopedic Surgery, Nagoya University Graduate School of Medicine; H. Ishikawa, MD, PhD, Orthopedic Surgery, Japanese Red Cross Nagoya Daiichi Hospital; K. Funahashi, MD, PhD, Orthopedic Surgery, Nagoya University Graduate School of Medicine; N. Ishiguro, MD, PhD, Orthopedic Surgery, Nagoya University Graduate School of Medicine. Address correspondence to Dr. Y. Hattori, National Hospital Organization Nagoya Medical Center, Orthopedic Surgery and Rheumatology, 4-1-1 Sannomaru, Naka-ku, Nagoya, Aichi 460-000, Japan. E-mail: yosuke-h@med.nagoya-u.ac.jp. Accepted for publication April 27, 2016.
Yuichiro Yabe
From the National Hospital Organization Nagoya Medical Center, Orthopedic Surgery and Rheumatology; Orthopedic Surgery, Nagoya University Graduate School of Medicine; Orthopedic Surgery, Nagoya Central Hospital; Ito Seikeigeka; Orthopedic Surgery and Rheumatology, Toyota Kosei Hospital; Orthopedic Surgery, Japanese Red Cross Nagoya Daiichi Hospital, Nagoya; Rheumatology, Toyohashi Municipal Hospital, Toyohashi; Orthopedic Surgery, Konan Kosei Hospital, Konan; Rheumatology, Japan Community Healthcare Organization Tokyo Shinjuku Medical Center, Tokyo; Orthopedic Surgery, Ichinomiya Municipal Hospital, Ichinomiya; Kato Clinic, Okazaki; Rheumatology, Nagano Red Cross Hospital, Nagano; Orthopedic Surgery, Anjo Kosei Hospital, Anjo, Japan. Y. Hattori, MD, PhD, Orthopedic Surgery and Rheumatology, National Hospital Organization Nagoya Medical Center; T. Kojima, MD, PhD, Department of Orthopedic Surgery, School of Medicine, Nagoya University; A. Kaneko, MD, Orthopedic Surgery and Rheumatology, National Hospital Organization Nagoya Medical Center; D. Kida, MD, PhD, Orthopedic Surgery and Rheumatology, National Hospital Organization Nagoya Medical Center; Y. Hirano, MD, PhD, Rheumatology Toyohashi Municipal Hospital; T. Fujibayashi, MD, PhD, Orthopedic Surgery, Konan Kosei Hospital; K. Terabe, MD, PhD, Orthopedic Surgery, Nagoya University Graduate School of Medicine; Y. Yabe, MD, PhD, Rheumatology, Japan Community Healthcare Organization Tokyo Shinjuku Medical Center; H. Miyake, MD, PhD, Orthopedic Surgery, Ichinomiya Municipal Hospital; T. Kato, MD, PhD, Kato Clinic; H. Takagi, MD, PhD, Orthopedic Surgery, Nagoya Central Hospital; M. Hayashi, MD, PhD, Rheumatology, Nagano Red Cross Hospital; T. Ito, MD, PhD, Ito Seikeigeka; Y. Kanayama, MD, PhD, Orthopedic Surgery and Rheumatology, Toyota Kosei Hospital; T. Oguchi, MD, PhD, Orthopedic Surgery, Anjo Kosei Hospital; N. Takahashi, MD, PhD, Orthopedic Surgery, Nagoya University Graduate School of Medicine; H. Ishikawa, MD, PhD, Orthopedic Surgery, Japanese Red Cross Nagoya Daiichi Hospital; K. Funahashi, MD, PhD, Orthopedic Surgery, Nagoya University Graduate School of Medicine; N. Ishiguro, MD, PhD, Orthopedic Surgery, Nagoya University Graduate School of Medicine. Address correspondence to Dr. Y. Hattori, National Hospital Organization Nagoya Medical Center, Orthopedic Surgery and Rheumatology, 4-1-1 Sannomaru, Naka-ku, Nagoya, Aichi 460-000, Japan. E-mail: yosuke-h@med.nagoya-u.ac.jp. Accepted for publication April 27, 2016.
Hiroyuki Miyake
From the National Hospital Organization Nagoya Medical Center, Orthopedic Surgery and Rheumatology; Orthopedic Surgery, Nagoya University Graduate School of Medicine; Orthopedic Surgery, Nagoya Central Hospital; Ito Seikeigeka; Orthopedic Surgery and Rheumatology, Toyota Kosei Hospital; Orthopedic Surgery, Japanese Red Cross Nagoya Daiichi Hospital, Nagoya; Rheumatology, Toyohashi Municipal Hospital, Toyohashi; Orthopedic Surgery, Konan Kosei Hospital, Konan; Rheumatology, Japan Community Healthcare Organization Tokyo Shinjuku Medical Center, Tokyo; Orthopedic Surgery, Ichinomiya Municipal Hospital, Ichinomiya; Kato Clinic, Okazaki; Rheumatology, Nagano Red Cross Hospital, Nagano; Orthopedic Surgery, Anjo Kosei Hospital, Anjo, Japan. Y. Hattori, MD, PhD, Orthopedic Surgery and Rheumatology, National Hospital Organization Nagoya Medical Center; T. Kojima, MD, PhD, Department of Orthopedic Surgery, School of Medicine, Nagoya University; A. Kaneko, MD, Orthopedic Surgery and Rheumatology, National Hospital Organization Nagoya Medical Center; D. Kida, MD, PhD, Orthopedic Surgery and Rheumatology, National Hospital Organization Nagoya Medical Center; Y. Hirano, MD, PhD, Rheumatology Toyohashi Municipal Hospital; T. Fujibayashi, MD, PhD, Orthopedic Surgery, Konan Kosei Hospital; K. Terabe, MD, PhD, Orthopedic Surgery, Nagoya University Graduate School of Medicine; Y. Yabe, MD, PhD, Rheumatology, Japan Community Healthcare Organization Tokyo Shinjuku Medical Center; H. Miyake, MD, PhD, Orthopedic Surgery, Ichinomiya Municipal Hospital; T. Kato, MD, PhD, Kato Clinic; H. Takagi, MD, PhD, Orthopedic Surgery, Nagoya Central Hospital; M. Hayashi, MD, PhD, Rheumatology, Nagano Red Cross Hospital; T. Ito, MD, PhD, Ito Seikeigeka; Y. Kanayama, MD, PhD, Orthopedic Surgery and Rheumatology, Toyota Kosei Hospital; T. Oguchi, MD, PhD, Orthopedic Surgery, Anjo Kosei Hospital; N. Takahashi, MD, PhD, Orthopedic Surgery, Nagoya University Graduate School of Medicine; H. Ishikawa, MD, PhD, Orthopedic Surgery, Japanese Red Cross Nagoya Daiichi Hospital; K. Funahashi, MD, PhD, Orthopedic Surgery, Nagoya University Graduate School of Medicine; N. Ishiguro, MD, PhD, Orthopedic Surgery, Nagoya University Graduate School of Medicine. Address correspondence to Dr. Y. Hattori, National Hospital Organization Nagoya Medical Center, Orthopedic Surgery and Rheumatology, 4-1-1 Sannomaru, Naka-ku, Nagoya, Aichi 460-000, Japan. E-mail: yosuke-h@med.nagoya-u.ac.jp. Accepted for publication April 27, 2016.
Takefumi Kato
From the National Hospital Organization Nagoya Medical Center, Orthopedic Surgery and Rheumatology; Orthopedic Surgery, Nagoya University Graduate School of Medicine; Orthopedic Surgery, Nagoya Central Hospital; Ito Seikeigeka; Orthopedic Surgery and Rheumatology, Toyota Kosei Hospital; Orthopedic Surgery, Japanese Red Cross Nagoya Daiichi Hospital, Nagoya; Rheumatology, Toyohashi Municipal Hospital, Toyohashi; Orthopedic Surgery, Konan Kosei Hospital, Konan; Rheumatology, Japan Community Healthcare Organization Tokyo Shinjuku Medical Center, Tokyo; Orthopedic Surgery, Ichinomiya Municipal Hospital, Ichinomiya; Kato Clinic, Okazaki; Rheumatology, Nagano Red Cross Hospital, Nagano; Orthopedic Surgery, Anjo Kosei Hospital, Anjo, Japan. Y. Hattori, MD, PhD, Orthopedic Surgery and Rheumatology, National Hospital Organization Nagoya Medical Center; T. Kojima, MD, PhD, Department of Orthopedic Surgery, School of Medicine, Nagoya University; A. Kaneko, MD, Orthopedic Surgery and Rheumatology, National Hospital Organization Nagoya Medical Center; D. Kida, MD, PhD, Orthopedic Surgery and Rheumatology, National Hospital Organization Nagoya Medical Center; Y. Hirano, MD, PhD, Rheumatology Toyohashi Municipal Hospital; T. Fujibayashi, MD, PhD, Orthopedic Surgery, Konan Kosei Hospital; K. Terabe, MD, PhD, Orthopedic Surgery, Nagoya University Graduate School of Medicine; Y. Yabe, MD, PhD, Rheumatology, Japan Community Healthcare Organization Tokyo Shinjuku Medical Center; H. Miyake, MD, PhD, Orthopedic Surgery, Ichinomiya Municipal Hospital; T. Kato, MD, PhD, Kato Clinic; H. Takagi, MD, PhD, Orthopedic Surgery, Nagoya Central Hospital; M. Hayashi, MD, PhD, Rheumatology, Nagano Red Cross Hospital; T. Ito, MD, PhD, Ito Seikeigeka; Y. Kanayama, MD, PhD, Orthopedic Surgery and Rheumatology, Toyota Kosei Hospital; T. Oguchi, MD, PhD, Orthopedic Surgery, Anjo Kosei Hospital; N. Takahashi, MD, PhD, Orthopedic Surgery, Nagoya University Graduate School of Medicine; H. Ishikawa, MD, PhD, Orthopedic Surgery, Japanese Red Cross Nagoya Daiichi Hospital; K. Funahashi, MD, PhD, Orthopedic Surgery, Nagoya University Graduate School of Medicine; N. Ishiguro, MD, PhD, Orthopedic Surgery, Nagoya University Graduate School of Medicine. Address correspondence to Dr. Y. Hattori, National Hospital Organization Nagoya Medical Center, Orthopedic Surgery and Rheumatology, 4-1-1 Sannomaru, Naka-ku, Nagoya, Aichi 460-000, Japan. E-mail: yosuke-h@med.nagoya-u.ac.jp. Accepted for publication April 27, 2016.
Hideki Takagi
From the National Hospital Organization Nagoya Medical Center, Orthopedic Surgery and Rheumatology; Orthopedic Surgery, Nagoya University Graduate School of Medicine; Orthopedic Surgery, Nagoya Central Hospital; Ito Seikeigeka; Orthopedic Surgery and Rheumatology, Toyota Kosei Hospital; Orthopedic Surgery, Japanese Red Cross Nagoya Daiichi Hospital, Nagoya; Rheumatology, Toyohashi Municipal Hospital, Toyohashi; Orthopedic Surgery, Konan Kosei Hospital, Konan; Rheumatology, Japan Community Healthcare Organization Tokyo Shinjuku Medical Center, Tokyo; Orthopedic Surgery, Ichinomiya Municipal Hospital, Ichinomiya; Kato Clinic, Okazaki; Rheumatology, Nagano Red Cross Hospital, Nagano; Orthopedic Surgery, Anjo Kosei Hospital, Anjo, Japan. Y. Hattori, MD, PhD, Orthopedic Surgery and Rheumatology, National Hospital Organization Nagoya Medical Center; T. Kojima, MD, PhD, Department of Orthopedic Surgery, School of Medicine, Nagoya University; A. Kaneko, MD, Orthopedic Surgery and Rheumatology, National Hospital Organization Nagoya Medical Center; D. Kida, MD, PhD, Orthopedic Surgery and Rheumatology, National Hospital Organization Nagoya Medical Center; Y. Hirano, MD, PhD, Rheumatology Toyohashi Municipal Hospital; T. Fujibayashi, MD, PhD, Orthopedic Surgery, Konan Kosei Hospital; K. Terabe, MD, PhD, Orthopedic Surgery, Nagoya University Graduate School of Medicine; Y. Yabe, MD, PhD, Rheumatology, Japan Community Healthcare Organization Tokyo Shinjuku Medical Center; H. Miyake, MD, PhD, Orthopedic Surgery, Ichinomiya Municipal Hospital; T. Kato, MD, PhD, Kato Clinic; H. Takagi, MD, PhD, Orthopedic Surgery, Nagoya Central Hospital; M. Hayashi, MD, PhD, Rheumatology, Nagano Red Cross Hospital; T. Ito, MD, PhD, Ito Seikeigeka; Y. Kanayama, MD, PhD, Orthopedic Surgery and Rheumatology, Toyota Kosei Hospital; T. Oguchi, MD, PhD, Orthopedic Surgery, Anjo Kosei Hospital; N. Takahashi, MD, PhD, Orthopedic Surgery, Nagoya University Graduate School of Medicine; H. Ishikawa, MD, PhD, Orthopedic Surgery, Japanese Red Cross Nagoya Daiichi Hospital; K. Funahashi, MD, PhD, Orthopedic Surgery, Nagoya University Graduate School of Medicine; N. Ishiguro, MD, PhD, Orthopedic Surgery, Nagoya University Graduate School of Medicine. Address correspondence to Dr. Y. Hattori, National Hospital Organization Nagoya Medical Center, Orthopedic Surgery and Rheumatology, 4-1-1 Sannomaru, Naka-ku, Nagoya, Aichi 460-000, Japan. E-mail: yosuke-h@med.nagoya-u.ac.jp. Accepted for publication April 27, 2016.
Masatoshi Hayashi
From the National Hospital Organization Nagoya Medical Center, Orthopedic Surgery and Rheumatology; Orthopedic Surgery, Nagoya University Graduate School of Medicine; Orthopedic Surgery, Nagoya Central Hospital; Ito Seikeigeka; Orthopedic Surgery and Rheumatology, Toyota Kosei Hospital; Orthopedic Surgery, Japanese Red Cross Nagoya Daiichi Hospital, Nagoya; Rheumatology, Toyohashi Municipal Hospital, Toyohashi; Orthopedic Surgery, Konan Kosei Hospital, Konan; Rheumatology, Japan Community Healthcare Organization Tokyo Shinjuku Medical Center, Tokyo; Orthopedic Surgery, Ichinomiya Municipal Hospital, Ichinomiya; Kato Clinic, Okazaki; Rheumatology, Nagano Red Cross Hospital, Nagano; Orthopedic Surgery, Anjo Kosei Hospital, Anjo, Japan. Y. Hattori, MD, PhD, Orthopedic Surgery and Rheumatology, National Hospital Organization Nagoya Medical Center; T. Kojima, MD, PhD, Department of Orthopedic Surgery, School of Medicine, Nagoya University; A. Kaneko, MD, Orthopedic Surgery and Rheumatology, National Hospital Organization Nagoya Medical Center; D. Kida, MD, PhD, Orthopedic Surgery and Rheumatology, National Hospital Organization Nagoya Medical Center; Y. Hirano, MD, PhD, Rheumatology Toyohashi Municipal Hospital; T. Fujibayashi, MD, PhD, Orthopedic Surgery, Konan Kosei Hospital; K. Terabe, MD, PhD, Orthopedic Surgery, Nagoya University Graduate School of Medicine; Y. Yabe, MD, PhD, Rheumatology, Japan Community Healthcare Organization Tokyo Shinjuku Medical Center; H. Miyake, MD, PhD, Orthopedic Surgery, Ichinomiya Municipal Hospital; T. Kato, MD, PhD, Kato Clinic; H. Takagi, MD, PhD, Orthopedic Surgery, Nagoya Central Hospital; M. Hayashi, MD, PhD, Rheumatology, Nagano Red Cross Hospital; T. Ito, MD, PhD, Ito Seikeigeka; Y. Kanayama, MD, PhD, Orthopedic Surgery and Rheumatology, Toyota Kosei Hospital; T. Oguchi, MD, PhD, Orthopedic Surgery, Anjo Kosei Hospital; N. Takahashi, MD, PhD, Orthopedic Surgery, Nagoya University Graduate School of Medicine; H. Ishikawa, MD, PhD, Orthopedic Surgery, Japanese Red Cross Nagoya Daiichi Hospital; K. Funahashi, MD, PhD, Orthopedic Surgery, Nagoya University Graduate School of Medicine; N. Ishiguro, MD, PhD, Orthopedic Surgery, Nagoya University Graduate School of Medicine. Address correspondence to Dr. Y. Hattori, National Hospital Organization Nagoya Medical Center, Orthopedic Surgery and Rheumatology, 4-1-1 Sannomaru, Naka-ku, Nagoya, Aichi 460-000, Japan. E-mail: yosuke-h@med.nagoya-u.ac.jp. Accepted for publication April 27, 2016.
Takayasu Ito
From the National Hospital Organization Nagoya Medical Center, Orthopedic Surgery and Rheumatology; Orthopedic Surgery, Nagoya University Graduate School of Medicine; Orthopedic Surgery, Nagoya Central Hospital; Ito Seikeigeka; Orthopedic Surgery and Rheumatology, Toyota Kosei Hospital; Orthopedic Surgery, Japanese Red Cross Nagoya Daiichi Hospital, Nagoya; Rheumatology, Toyohashi Municipal Hospital, Toyohashi; Orthopedic Surgery, Konan Kosei Hospital, Konan; Rheumatology, Japan Community Healthcare Organization Tokyo Shinjuku Medical Center, Tokyo; Orthopedic Surgery, Ichinomiya Municipal Hospital, Ichinomiya; Kato Clinic, Okazaki; Rheumatology, Nagano Red Cross Hospital, Nagano; Orthopedic Surgery, Anjo Kosei Hospital, Anjo, Japan. Y. Hattori, MD, PhD, Orthopedic Surgery and Rheumatology, National Hospital Organization Nagoya Medical Center; T. Kojima, MD, PhD, Department of Orthopedic Surgery, School of Medicine, Nagoya University; A. Kaneko, MD, Orthopedic Surgery and Rheumatology, National Hospital Organization Nagoya Medical Center; D. Kida, MD, PhD, Orthopedic Surgery and Rheumatology, National Hospital Organization Nagoya Medical Center; Y. Hirano, MD, PhD, Rheumatology Toyohashi Municipal Hospital; T. Fujibayashi, MD, PhD, Orthopedic Surgery, Konan Kosei Hospital; K. Terabe, MD, PhD, Orthopedic Surgery, Nagoya University Graduate School of Medicine; Y. Yabe, MD, PhD, Rheumatology, Japan Community Healthcare Organization Tokyo Shinjuku Medical Center; H. Miyake, MD, PhD, Orthopedic Surgery, Ichinomiya Municipal Hospital; T. Kato, MD, PhD, Kato Clinic; H. Takagi, MD, PhD, Orthopedic Surgery, Nagoya Central Hospital; M. Hayashi, MD, PhD, Rheumatology, Nagano Red Cross Hospital; T. Ito, MD, PhD, Ito Seikeigeka; Y. Kanayama, MD, PhD, Orthopedic Surgery and Rheumatology, Toyota Kosei Hospital; T. Oguchi, MD, PhD, Orthopedic Surgery, Anjo Kosei Hospital; N. Takahashi, MD, PhD, Orthopedic Surgery, Nagoya University Graduate School of Medicine; H. Ishikawa, MD, PhD, Orthopedic Surgery, Japanese Red Cross Nagoya Daiichi Hospital; K. Funahashi, MD, PhD, Orthopedic Surgery, Nagoya University Graduate School of Medicine; N. Ishiguro, MD, PhD, Orthopedic Surgery, Nagoya University Graduate School of Medicine. Address correspondence to Dr. Y. Hattori, National Hospital Organization Nagoya Medical Center, Orthopedic Surgery and Rheumatology, 4-1-1 Sannomaru, Naka-ku, Nagoya, Aichi 460-000, Japan. E-mail: yosuke-h@med.nagoya-u.ac.jp. Accepted for publication April 27, 2016.
Yasuhide Kanayama
From the National Hospital Organization Nagoya Medical Center, Orthopedic Surgery and Rheumatology; Orthopedic Surgery, Nagoya University Graduate School of Medicine; Orthopedic Surgery, Nagoya Central Hospital; Ito Seikeigeka; Orthopedic Surgery and Rheumatology, Toyota Kosei Hospital; Orthopedic Surgery, Japanese Red Cross Nagoya Daiichi Hospital, Nagoya; Rheumatology, Toyohashi Municipal Hospital, Toyohashi; Orthopedic Surgery, Konan Kosei Hospital, Konan; Rheumatology, Japan Community Healthcare Organization Tokyo Shinjuku Medical Center, Tokyo; Orthopedic Surgery, Ichinomiya Municipal Hospital, Ichinomiya; Kato Clinic, Okazaki; Rheumatology, Nagano Red Cross Hospital, Nagano; Orthopedic Surgery, Anjo Kosei Hospital, Anjo, Japan. Y. Hattori, MD, PhD, Orthopedic Surgery and Rheumatology, National Hospital Organization Nagoya Medical Center; T. Kojima, MD, PhD, Department of Orthopedic Surgery, School of Medicine, Nagoya University; A. Kaneko, MD, Orthopedic Surgery and Rheumatology, National Hospital Organization Nagoya Medical Center; D. Kida, MD, PhD, Orthopedic Surgery and Rheumatology, National Hospital Organization Nagoya Medical Center; Y. Hirano, MD, PhD, Rheumatology Toyohashi Municipal Hospital; T. Fujibayashi, MD, PhD, Orthopedic Surgery, Konan Kosei Hospital; K. Terabe, MD, PhD, Orthopedic Surgery, Nagoya University Graduate School of Medicine; Y. Yabe, MD, PhD, Rheumatology, Japan Community Healthcare Organization Tokyo Shinjuku Medical Center; H. Miyake, MD, PhD, Orthopedic Surgery, Ichinomiya Municipal Hospital; T. Kato, MD, PhD, Kato Clinic; H. Takagi, MD, PhD, Orthopedic Surgery, Nagoya Central Hospital; M. Hayashi, MD, PhD, Rheumatology, Nagano Red Cross Hospital; T. Ito, MD, PhD, Ito Seikeigeka; Y. Kanayama, MD, PhD, Orthopedic Surgery and Rheumatology, Toyota Kosei Hospital; T. Oguchi, MD, PhD, Orthopedic Surgery, Anjo Kosei Hospital; N. Takahashi, MD, PhD, Orthopedic Surgery, Nagoya University Graduate School of Medicine; H. Ishikawa, MD, PhD, Orthopedic Surgery, Japanese Red Cross Nagoya Daiichi Hospital; K. Funahashi, MD, PhD, Orthopedic Surgery, Nagoya University Graduate School of Medicine; N. Ishiguro, MD, PhD, Orthopedic Surgery, Nagoya University Graduate School of Medicine. Address correspondence to Dr. Y. Hattori, National Hospital Organization Nagoya Medical Center, Orthopedic Surgery and Rheumatology, 4-1-1 Sannomaru, Naka-ku, Nagoya, Aichi 460-000, Japan. E-mail: yosuke-h@med.nagoya-u.ac.jp. Accepted for publication April 27, 2016.
Takeshi Oguchi
From the National Hospital Organization Nagoya Medical Center, Orthopedic Surgery and Rheumatology; Orthopedic Surgery, Nagoya University Graduate School of Medicine; Orthopedic Surgery, Nagoya Central Hospital; Ito Seikeigeka; Orthopedic Surgery and Rheumatology, Toyota Kosei Hospital; Orthopedic Surgery, Japanese Red Cross Nagoya Daiichi Hospital, Nagoya; Rheumatology, Toyohashi Municipal Hospital, Toyohashi; Orthopedic Surgery, Konan Kosei Hospital, Konan; Rheumatology, Japan Community Healthcare Organization Tokyo Shinjuku Medical Center, Tokyo; Orthopedic Surgery, Ichinomiya Municipal Hospital, Ichinomiya; Kato Clinic, Okazaki; Rheumatology, Nagano Red Cross Hospital, Nagano; Orthopedic Surgery, Anjo Kosei Hospital, Anjo, Japan. Y. Hattori, MD, PhD, Orthopedic Surgery and Rheumatology, National Hospital Organization Nagoya Medical Center; T. Kojima, MD, PhD, Department of Orthopedic Surgery, School of Medicine, Nagoya University; A. Kaneko, MD, Orthopedic Surgery and Rheumatology, National Hospital Organization Nagoya Medical Center; D. Kida, MD, PhD, Orthopedic Surgery and Rheumatology, National Hospital Organization Nagoya Medical Center; Y. Hirano, MD, PhD, Rheumatology Toyohashi Municipal Hospital; T. Fujibayashi, MD, PhD, Orthopedic Surgery, Konan Kosei Hospital; K. Terabe, MD, PhD, Orthopedic Surgery, Nagoya University Graduate School of Medicine; Y. Yabe, MD, PhD, Rheumatology, Japan Community Healthcare Organization Tokyo Shinjuku Medical Center; H. Miyake, MD, PhD, Orthopedic Surgery, Ichinomiya Municipal Hospital; T. Kato, MD, PhD, Kato Clinic; H. Takagi, MD, PhD, Orthopedic Surgery, Nagoya Central Hospital; M. Hayashi, MD, PhD, Rheumatology, Nagano Red Cross Hospital; T. Ito, MD, PhD, Ito Seikeigeka; Y. Kanayama, MD, PhD, Orthopedic Surgery and Rheumatology, Toyota Kosei Hospital; T. Oguchi, MD, PhD, Orthopedic Surgery, Anjo Kosei Hospital; N. Takahashi, MD, PhD, Orthopedic Surgery, Nagoya University Graduate School of Medicine; H. Ishikawa, MD, PhD, Orthopedic Surgery, Japanese Red Cross Nagoya Daiichi Hospital; K. Funahashi, MD, PhD, Orthopedic Surgery, Nagoya University Graduate School of Medicine; N. Ishiguro, MD, PhD, Orthopedic Surgery, Nagoya University Graduate School of Medicine. Address correspondence to Dr. Y. Hattori, National Hospital Organization Nagoya Medical Center, Orthopedic Surgery and Rheumatology, 4-1-1 Sannomaru, Naka-ku, Nagoya, Aichi 460-000, Japan. E-mail: yosuke-h@med.nagoya-u.ac.jp. Accepted for publication April 27, 2016.
Nobunori Takahashi
From the National Hospital Organization Nagoya Medical Center, Orthopedic Surgery and Rheumatology; Orthopedic Surgery, Nagoya University Graduate School of Medicine; Orthopedic Surgery, Nagoya Central Hospital; Ito Seikeigeka; Orthopedic Surgery and Rheumatology, Toyota Kosei Hospital; Orthopedic Surgery, Japanese Red Cross Nagoya Daiichi Hospital, Nagoya; Rheumatology, Toyohashi Municipal Hospital, Toyohashi; Orthopedic Surgery, Konan Kosei Hospital, Konan; Rheumatology, Japan Community Healthcare Organization Tokyo Shinjuku Medical Center, Tokyo; Orthopedic Surgery, Ichinomiya Municipal Hospital, Ichinomiya; Kato Clinic, Okazaki; Rheumatology, Nagano Red Cross Hospital, Nagano; Orthopedic Surgery, Anjo Kosei Hospital, Anjo, Japan. Y. Hattori, MD, PhD, Orthopedic Surgery and Rheumatology, National Hospital Organization Nagoya Medical Center; T. Kojima, MD, PhD, Department of Orthopedic Surgery, School of Medicine, Nagoya University; A. Kaneko, MD, Orthopedic Surgery and Rheumatology, National Hospital Organization Nagoya Medical Center; D. Kida, MD, PhD, Orthopedic Surgery and Rheumatology, National Hospital Organization Nagoya Medical Center; Y. Hirano, MD, PhD, Rheumatology Toyohashi Municipal Hospital; T. Fujibayashi, MD, PhD, Orthopedic Surgery, Konan Kosei Hospital; K. Terabe, MD, PhD, Orthopedic Surgery, Nagoya University Graduate School of Medicine; Y. Yabe, MD, PhD, Rheumatology, Japan Community Healthcare Organization Tokyo Shinjuku Medical Center; H. Miyake, MD, PhD, Orthopedic Surgery, Ichinomiya Municipal Hospital; T. Kato, MD, PhD, Kato Clinic; H. Takagi, MD, PhD, Orthopedic Surgery, Nagoya Central Hospital; M. Hayashi, MD, PhD, Rheumatology, Nagano Red Cross Hospital; T. Ito, MD, PhD, Ito Seikeigeka; Y. Kanayama, MD, PhD, Orthopedic Surgery and Rheumatology, Toyota Kosei Hospital; T. Oguchi, MD, PhD, Orthopedic Surgery, Anjo Kosei Hospital; N. Takahashi, MD, PhD, Orthopedic Surgery, Nagoya University Graduate School of Medicine; H. Ishikawa, MD, PhD, Orthopedic Surgery, Japanese Red Cross Nagoya Daiichi Hospital; K. Funahashi, MD, PhD, Orthopedic Surgery, Nagoya University Graduate School of Medicine; N. Ishiguro, MD, PhD, Orthopedic Surgery, Nagoya University Graduate School of Medicine. Address correspondence to Dr. Y. Hattori, National Hospital Organization Nagoya Medical Center, Orthopedic Surgery and Rheumatology, 4-1-1 Sannomaru, Naka-ku, Nagoya, Aichi 460-000, Japan. E-mail: yosuke-h@med.nagoya-u.ac.jp. Accepted for publication April 27, 2016.
Hisato Ishikawa
From the National Hospital Organization Nagoya Medical Center, Orthopedic Surgery and Rheumatology; Orthopedic Surgery, Nagoya University Graduate School of Medicine; Orthopedic Surgery, Nagoya Central Hospital; Ito Seikeigeka; Orthopedic Surgery and Rheumatology, Toyota Kosei Hospital; Orthopedic Surgery, Japanese Red Cross Nagoya Daiichi Hospital, Nagoya; Rheumatology, Toyohashi Municipal Hospital, Toyohashi; Orthopedic Surgery, Konan Kosei Hospital, Konan; Rheumatology, Japan Community Healthcare Organization Tokyo Shinjuku Medical Center, Tokyo; Orthopedic Surgery, Ichinomiya Municipal Hospital, Ichinomiya; Kato Clinic, Okazaki; Rheumatology, Nagano Red Cross Hospital, Nagano; Orthopedic Surgery, Anjo Kosei Hospital, Anjo, Japan. Y. Hattori, MD, PhD, Orthopedic Surgery and Rheumatology, National Hospital Organization Nagoya Medical Center; T. Kojima, MD, PhD, Department of Orthopedic Surgery, School of Medicine, Nagoya University; A. Kaneko, MD, Orthopedic Surgery and Rheumatology, National Hospital Organization Nagoya Medical Center; D. Kida, MD, PhD, Orthopedic Surgery and Rheumatology, National Hospital Organization Nagoya Medical Center; Y. Hirano, MD, PhD, Rheumatology Toyohashi Municipal Hospital; T. Fujibayashi, MD, PhD, Orthopedic Surgery, Konan Kosei Hospital; K. Terabe, MD, PhD, Orthopedic Surgery, Nagoya University Graduate School of Medicine; Y. Yabe, MD, PhD, Rheumatology, Japan Community Healthcare Organization Tokyo Shinjuku Medical Center; H. Miyake, MD, PhD, Orthopedic Surgery, Ichinomiya Municipal Hospital; T. Kato, MD, PhD, Kato Clinic; H. Takagi, MD, PhD, Orthopedic Surgery, Nagoya Central Hospital; M. Hayashi, MD, PhD, Rheumatology, Nagano Red Cross Hospital; T. Ito, MD, PhD, Ito Seikeigeka; Y. Kanayama, MD, PhD, Orthopedic Surgery and Rheumatology, Toyota Kosei Hospital; T. Oguchi, MD, PhD, Orthopedic Surgery, Anjo Kosei Hospital; N. Takahashi, MD, PhD, Orthopedic Surgery, Nagoya University Graduate School of Medicine; H. Ishikawa, MD, PhD, Orthopedic Surgery, Japanese Red Cross Nagoya Daiichi Hospital; K. Funahashi, MD, PhD, Orthopedic Surgery, Nagoya University Graduate School of Medicine; N. Ishiguro, MD, PhD, Orthopedic Surgery, Nagoya University Graduate School of Medicine. Address correspondence to Dr. Y. Hattori, National Hospital Organization Nagoya Medical Center, Orthopedic Surgery and Rheumatology, 4-1-1 Sannomaru, Naka-ku, Nagoya, Aichi 460-000, Japan. E-mail: yosuke-h@med.nagoya-u.ac.jp. Accepted for publication April 27, 2016.
Koji Funahashi
From the National Hospital Organization Nagoya Medical Center, Orthopedic Surgery and Rheumatology; Orthopedic Surgery, Nagoya University Graduate School of Medicine; Orthopedic Surgery, Nagoya Central Hospital; Ito Seikeigeka; Orthopedic Surgery and Rheumatology, Toyota Kosei Hospital; Orthopedic Surgery, Japanese Red Cross Nagoya Daiichi Hospital, Nagoya; Rheumatology, Toyohashi Municipal Hospital, Toyohashi; Orthopedic Surgery, Konan Kosei Hospital, Konan; Rheumatology, Japan Community Healthcare Organization Tokyo Shinjuku Medical Center, Tokyo; Orthopedic Surgery, Ichinomiya Municipal Hospital, Ichinomiya; Kato Clinic, Okazaki; Rheumatology, Nagano Red Cross Hospital, Nagano; Orthopedic Surgery, Anjo Kosei Hospital, Anjo, Japan. Y. Hattori, MD, PhD, Orthopedic Surgery and Rheumatology, National Hospital Organization Nagoya Medical Center; T. Kojima, MD, PhD, Department of Orthopedic Surgery, School of Medicine, Nagoya University; A. Kaneko, MD, Orthopedic Surgery and Rheumatology, National Hospital Organization Nagoya Medical Center; D. Kida, MD, PhD, Orthopedic Surgery and Rheumatology, National Hospital Organization Nagoya Medical Center; Y. Hirano, MD, PhD, Rheumatology Toyohashi Municipal Hospital; T. Fujibayashi, MD, PhD, Orthopedic Surgery, Konan Kosei Hospital; K. Terabe, MD, PhD, Orthopedic Surgery, Nagoya University Graduate School of Medicine; Y. Yabe, MD, PhD, Rheumatology, Japan Community Healthcare Organization Tokyo Shinjuku Medical Center; H. Miyake, MD, PhD, Orthopedic Surgery, Ichinomiya Municipal Hospital; T. Kato, MD, PhD, Kato Clinic; H. Takagi, MD, PhD, Orthopedic Surgery, Nagoya Central Hospital; M. Hayashi, MD, PhD, Rheumatology, Nagano Red Cross Hospital; T. Ito, MD, PhD, Ito Seikeigeka; Y. Kanayama, MD, PhD, Orthopedic Surgery and Rheumatology, Toyota Kosei Hospital; T. Oguchi, MD, PhD, Orthopedic Surgery, Anjo Kosei Hospital; N. Takahashi, MD, PhD, Orthopedic Surgery, Nagoya University Graduate School of Medicine; H. Ishikawa, MD, PhD, Orthopedic Surgery, Japanese Red Cross Nagoya Daiichi Hospital; K. Funahashi, MD, PhD, Orthopedic Surgery, Nagoya University Graduate School of Medicine; N. Ishiguro, MD, PhD, Orthopedic Surgery, Nagoya University Graduate School of Medicine. Address correspondence to Dr. Y. Hattori, National Hospital Organization Nagoya Medical Center, Orthopedic Surgery and Rheumatology, 4-1-1 Sannomaru, Naka-ku, Nagoya, Aichi 460-000, Japan. E-mail: yosuke-h@med.nagoya-u.ac.jp. Accepted for publication April 27, 2016.
Naoki Ishiguro
From the National Hospital Organization Nagoya Medical Center, Orthopedic Surgery and Rheumatology; Orthopedic Surgery, Nagoya University Graduate School of Medicine; Orthopedic Surgery, Nagoya Central Hospital; Ito Seikeigeka; Orthopedic Surgery and Rheumatology, Toyota Kosei Hospital; Orthopedic Surgery, Japanese Red Cross Nagoya Daiichi Hospital, Nagoya; Rheumatology, Toyohashi Municipal Hospital, Toyohashi; Orthopedic Surgery, Konan Kosei Hospital, Konan; Rheumatology, Japan Community Healthcare Organization Tokyo Shinjuku Medical Center, Tokyo; Orthopedic Surgery, Ichinomiya Municipal Hospital, Ichinomiya; Kato Clinic, Okazaki; Rheumatology, Nagano Red Cross Hospital, Nagano; Orthopedic Surgery, Anjo Kosei Hospital, Anjo, Japan. Y. Hattori, MD, PhD, Orthopedic Surgery and Rheumatology, National Hospital Organization Nagoya Medical Center; T. Kojima, MD, PhD, Department of Orthopedic Surgery, School of Medicine, Nagoya University; A. Kaneko, MD, Orthopedic Surgery and Rheumatology, National Hospital Organization Nagoya Medical Center; D. Kida, MD, PhD, Orthopedic Surgery and Rheumatology, National Hospital Organization Nagoya Medical Center; Y. Hirano, MD, PhD, Rheumatology Toyohashi Municipal Hospital; T. Fujibayashi, MD, PhD, Orthopedic Surgery, Konan Kosei Hospital; K. Terabe, MD, PhD, Orthopedic Surgery, Nagoya University Graduate School of Medicine; Y. Yabe, MD, PhD, Rheumatology, Japan Community Healthcare Organization Tokyo Shinjuku Medical Center; H. Miyake, MD, PhD, Orthopedic Surgery, Ichinomiya Municipal Hospital; T. Kato, MD, PhD, Kato Clinic; H. Takagi, MD, PhD, Orthopedic Surgery, Nagoya Central Hospital; M. Hayashi, MD, PhD, Rheumatology, Nagano Red Cross Hospital; T. Ito, MD, PhD, Ito Seikeigeka; Y. Kanayama, MD, PhD, Orthopedic Surgery and Rheumatology, Toyota Kosei Hospital; T. Oguchi, MD, PhD, Orthopedic Surgery, Anjo Kosei Hospital; N. Takahashi, MD, PhD, Orthopedic Surgery, Nagoya University Graduate School of Medicine; H. Ishikawa, MD, PhD, Orthopedic Surgery, Japanese Red Cross Nagoya Daiichi Hospital; K. Funahashi, MD, PhD, Orthopedic Surgery, Nagoya University Graduate School of Medicine; N. Ishiguro, MD, PhD, Orthopedic Surgery, Nagoya University Graduate School of Medicine. Address correspondence to Dr. Y. Hattori, National Hospital Organization Nagoya Medical Center, Orthopedic Surgery and Rheumatology, 4-1-1 Sannomaru, Naka-ku, Nagoya, Aichi 460-000, Japan. E-mail: yosuke-h@med.nagoya-u.ac.jp. Accepted for publication April 27, 2016.
Abstract
Objective To evaluate the rates of retention and discontinuation of adalimumab (ADA) due to efficacy and safety in Japanese patients with rheumatoid arthritis (RA).
Methods All patients with RA (n = 476) who were treated with ADA in the Tsurumai Biologics Communication Registry were enrolled.
Results The retention rate of ADA was 46% at 5 years. When focusing on insufficient efficacy, previous biologics use and high baseline disease activity were significant risk factors for up to 1 year. Methotrexate (MTX) use was a significantly low risk factor after 1 year of treatment.
Conclusion Concomitant MTX contributes to the longterm efficacy of ADA therapy.
In this issue
The Journal of Rheumatology
Vol. 51, Issue 4
1 Apr 2024
Longterm Retention Rate and Risk Factors for Adalimumab Discontinuation Due To Efficacy and Safety in Japanese Patients with Rheumatoid Arthritis: An Observational Cohort Study
Yosuke Hattori, Toshihisa Kojima, Atsushi Kaneko, Daihei Kida, Yuji Hirano, Takayoshi Fujibayashi, Kenya Terabe, Yuichiro Yabe, Hiroyuki Miyake, Takefumi Kato, Hideki Takagi, Masatoshi Hayashi, Takayasu Ito, Yasuhide Kanayama, Takeshi Oguchi, Nobunori Takahashi, Hisato Ishikawa, Koji Funahashi, Naoki Ishiguro
The Journal of Rheumatology Jun 2016, jrheum.151006; DOI: 10.3899/jrheum.151006
Longterm Retention Rate and Risk Factors for Adalimumab Discontinuation Due To Efficacy and Safety in Japanese Patients with Rheumatoid Arthritis: An Observational Cohort Study
Yosuke Hattori, Toshihisa Kojima, Atsushi Kaneko, Daihei Kida, Yuji Hirano, Takayoshi Fujibayashi, Kenya Terabe, Yuichiro Yabe, Hiroyuki Miyake, Takefumi Kato, Hideki Takagi, Masatoshi Hayashi, Takayasu Ito, Yasuhide Kanayama, Takeshi Oguchi, Nobunori Takahashi, Hisato Ishikawa, Koji Funahashi, Naoki Ishiguro
The Journal of Rheumatology Jun 2016, jrheum.151006; DOI: 10.3899/jrheum.151006