Research ArticleArticle
Copy Number Variation of HLA-DQA1 and APOBEC3A/3B Contribute to the Susceptibility of Systemic Sclerosis in the Chinese Han Population
Shicheng Guo, Yuan Li, Yi Wang, Haiyan Chu, Yulin Chen, Qingmei Liu, Gang Guo, Wenzhen Tu, Wenyu Wu, Hejian Zou, Li Yang, Rong Xiao, Yanyun Ma, Feng Zhang, Momiao Xiong, Li Jin, Xiaodong Zhou and Jiucun Wang
The Journal of Rheumatology April 2016, jrheum.150945; DOI: https://doi.org/10.3899/jrheum.150945
Shicheng Guo
From the State Key Laboratory of Genetic Engineering and Ministry of Education Key Laboratory of Contemporary Anthropology, Collaborative Innovation Center for Genetics and Development, School of Life Sciences and Institutes of Biomedical Sciences, Fudan University; Institute of Rheumatology, Immunology and Allergy, Fudan University; Shanghai Traditional Chinese Medicine (TCM)-Integrated Hospital; Division of Dermatology, and Division of Rheumatology, Huashan Hospital, Fudan University, Shanghai; Yiling Hospital, Shijiazhuang; Division of Rheumatology, Teaching Hospital of Chengdu University of TCM, Chengdu; Department of Dermatology, Second Xiangya Hospital, Central South University, Changsha, China; School of Public Health, and Medical School at Houston, University of Texas, Houston, Texas, USA. Supported by research grants from the National Basic Research Program (2012CB944604), National Science Foundation of China (81270120, 81470254), International S&T Cooperation Program of China (2013DFA30870), the 111 Project (B13016), and the US National Institutes of Health (NIH) NIAID UO1, 1U01AI09090. The computations involved in this study were supported by Fudan University High-End Computing Center. Mr. Xiong was supported by Grant 1R01AR057120–01 and 1R01HL106034-01, from the NIH and the US National Heart, Lung, and Blood Institute. S. Guo, PhD, State Key Laboratory of Genetic Engineering and Ministry of Education Key Laboratory of Contemporary Anthropology, Collaborative Innovation Center for Genetics and Development, School of Life Sciences and Institutes of Biomedical Sciences, Fudan University, and Institute of Rheumatology, Immunology and Allergy, Fudan University; Y. Li, MS, State Key Laboratory of Genetic Engineering and Ministry of Education Key Laboratory of Contemporary Anthropology, Collaborative Innovation Center for Genetics and Development, School of Life Sciences and Institutes of Biomedical Sciences, Fudan University; Y. Wang, PhD, State Key Laboratory of Genetic Engineering and Ministry of Education Key Laboratory of Contemporary Anthropology, Collaborative Innovation Center for Genetics and Development, School of Life Sciences and Institutes of Biomedical Sciences, Fudan University; H. Chu, PhD, State Key Laboratory of Genetic Engineering and Ministry of Education Key Laboratory of Contemporary Anthropology, Collaborative Innovation Center for Genetics and Development, School of Life Sciences and Institutes of Biomedical Sciences, Fudan University; Y. Chen, PhD, State Key Laboratory of Genetic Engineering and Ministry of Education Key Laboratory of Contemporary Anthropology, Collaborative Innovation Center for Genetics and Development, School of Life Sciences and Institutes of Biomedical Sciences, Fudan University; Q. Liu, PhD, State Key Laboratory of Genetic Engineering and Ministry of Education Key Laboratory of Contemporary Anthropology, Collaborative Innovation Center for Genetics and Development, School of Life Sciences and Institutes of Biomedical Sciences, Fudan University; G. Guo, MD, Yiling Hospital; W. Tu, MD, Shanghai TCM-Integrated Hospital; W. Wu, MD, Institute of Rheumatology, Immunology and Allergy, Fudan University, and Division of Dermatology, Huashan Hospital, Fudan University; H. Zou, PhD, MD, Institute of Rheumatology, Immunology and Allergy, Fudan University, and Division of Rheumatology, Huashan Hospital, Fudan University; L. Yang, MD, Division of Rheumatology, Teaching Hospital of Chengdu University of TCM; R. Xiao, MD, Department of Dermatology, Second Xiangya Hospital, Central South University; Y. Ma, MS, State Key Laboratory of Genetic Engineering and Ministry of Education Key Laboratory of Contemporary Anthropology, Collaborative Innovation Center for Genetics and Development, School of Life Sciences and Institutes of Biomedical Sciences, Fudan University; F. Zhang, PhD, State Key Laboratory of Genetic Engineering and Ministry of Education Key Laboratory of Contemporary Anthropology, Collaborative Innovation Center for Genetics and Development, School of Life Sciences and Institutes of Biomedical Sciences, Fudan University; M. Xiong, PhD, School of Public Health, University of Texas; L. Jin, PhD, State Key Laboratory of Genetic Engineering and Ministry of Education Key Laboratory of Contemporary Anthropology, Collaborative Innovation Center for Genetics and Development, School of Life Sciences and Institutes of Biomedical Sciences, Fudan University; X. Zhou, MD, Medical School at Houston, University of Texas; J. Wang, PhD, State Key Laboratory of Genetic Engineering and Ministry of Education Key Laboratory of Contemporary Anthropology, Collaborative Innovation Center for Genetics and Development, School of Life Sciences and Institutes of Biomedical Sciences, Fudan University, and Institute of Rheumatology, Immunology and Allergy, Fudan University. Address correspondence to J. Wang, School of Life Sciences, Fudan University Jiangwan Campus, 2005 Songhu Road, Shanghai 200438, China. E-mail: jcwang@fudan.edu.cn. Accepted for publication January 26, 2016.
Yuan Li
From the State Key Laboratory of Genetic Engineering and Ministry of Education Key Laboratory of Contemporary Anthropology, Collaborative Innovation Center for Genetics and Development, School of Life Sciences and Institutes of Biomedical Sciences, Fudan University; Institute of Rheumatology, Immunology and Allergy, Fudan University; Shanghai Traditional Chinese Medicine (TCM)-Integrated Hospital; Division of Dermatology, and Division of Rheumatology, Huashan Hospital, Fudan University, Shanghai; Yiling Hospital, Shijiazhuang; Division of Rheumatology, Teaching Hospital of Chengdu University of TCM, Chengdu; Department of Dermatology, Second Xiangya Hospital, Central South University, Changsha, China; School of Public Health, and Medical School at Houston, University of Texas, Houston, Texas, USA. Supported by research grants from the National Basic Research Program (2012CB944604), National Science Foundation of China (81270120, 81470254), International S&T Cooperation Program of China (2013DFA30870), the 111 Project (B13016), and the US National Institutes of Health (NIH) NIAID UO1, 1U01AI09090. The computations involved in this study were supported by Fudan University High-End Computing Center. Mr. Xiong was supported by Grant 1R01AR057120–01 and 1R01HL106034-01, from the NIH and the US National Heart, Lung, and Blood Institute. S. Guo, PhD, State Key Laboratory of Genetic Engineering and Ministry of Education Key Laboratory of Contemporary Anthropology, Collaborative Innovation Center for Genetics and Development, School of Life Sciences and Institutes of Biomedical Sciences, Fudan University, and Institute of Rheumatology, Immunology and Allergy, Fudan University; Y. Li, MS, State Key Laboratory of Genetic Engineering and Ministry of Education Key Laboratory of Contemporary Anthropology, Collaborative Innovation Center for Genetics and Development, School of Life Sciences and Institutes of Biomedical Sciences, Fudan University; Y. Wang, PhD, State Key Laboratory of Genetic Engineering and Ministry of Education Key Laboratory of Contemporary Anthropology, Collaborative Innovation Center for Genetics and Development, School of Life Sciences and Institutes of Biomedical Sciences, Fudan University; H. Chu, PhD, State Key Laboratory of Genetic Engineering and Ministry of Education Key Laboratory of Contemporary Anthropology, Collaborative Innovation Center for Genetics and Development, School of Life Sciences and Institutes of Biomedical Sciences, Fudan University; Y. Chen, PhD, State Key Laboratory of Genetic Engineering and Ministry of Education Key Laboratory of Contemporary Anthropology, Collaborative Innovation Center for Genetics and Development, School of Life Sciences and Institutes of Biomedical Sciences, Fudan University; Q. Liu, PhD, State Key Laboratory of Genetic Engineering and Ministry of Education Key Laboratory of Contemporary Anthropology, Collaborative Innovation Center for Genetics and Development, School of Life Sciences and Institutes of Biomedical Sciences, Fudan University; G. Guo, MD, Yiling Hospital; W. Tu, MD, Shanghai TCM-Integrated Hospital; W. Wu, MD, Institute of Rheumatology, Immunology and Allergy, Fudan University, and Division of Dermatology, Huashan Hospital, Fudan University; H. Zou, PhD, MD, Institute of Rheumatology, Immunology and Allergy, Fudan University, and Division of Rheumatology, Huashan Hospital, Fudan University; L. Yang, MD, Division of Rheumatology, Teaching Hospital of Chengdu University of TCM; R. Xiao, MD, Department of Dermatology, Second Xiangya Hospital, Central South University; Y. Ma, MS, State Key Laboratory of Genetic Engineering and Ministry of Education Key Laboratory of Contemporary Anthropology, Collaborative Innovation Center for Genetics and Development, School of Life Sciences and Institutes of Biomedical Sciences, Fudan University; F. Zhang, PhD, State Key Laboratory of Genetic Engineering and Ministry of Education Key Laboratory of Contemporary Anthropology, Collaborative Innovation Center for Genetics and Development, School of Life Sciences and Institutes of Biomedical Sciences, Fudan University; M. Xiong, PhD, School of Public Health, University of Texas; L. Jin, PhD, State Key Laboratory of Genetic Engineering and Ministry of Education Key Laboratory of Contemporary Anthropology, Collaborative Innovation Center for Genetics and Development, School of Life Sciences and Institutes of Biomedical Sciences, Fudan University; X. Zhou, MD, Medical School at Houston, University of Texas; J. Wang, PhD, State Key Laboratory of Genetic Engineering and Ministry of Education Key Laboratory of Contemporary Anthropology, Collaborative Innovation Center for Genetics and Development, School of Life Sciences and Institutes of Biomedical Sciences, Fudan University, and Institute of Rheumatology, Immunology and Allergy, Fudan University. Address correspondence to J. Wang, School of Life Sciences, Fudan University Jiangwan Campus, 2005 Songhu Road, Shanghai 200438, China. E-mail: jcwang@fudan.edu.cn. Accepted for publication January 26, 2016.
Yi Wang
From the State Key Laboratory of Genetic Engineering and Ministry of Education Key Laboratory of Contemporary Anthropology, Collaborative Innovation Center for Genetics and Development, School of Life Sciences and Institutes of Biomedical Sciences, Fudan University; Institute of Rheumatology, Immunology and Allergy, Fudan University; Shanghai Traditional Chinese Medicine (TCM)-Integrated Hospital; Division of Dermatology, and Division of Rheumatology, Huashan Hospital, Fudan University, Shanghai; Yiling Hospital, Shijiazhuang; Division of Rheumatology, Teaching Hospital of Chengdu University of TCM, Chengdu; Department of Dermatology, Second Xiangya Hospital, Central South University, Changsha, China; School of Public Health, and Medical School at Houston, University of Texas, Houston, Texas, USA. Supported by research grants from the National Basic Research Program (2012CB944604), National Science Foundation of China (81270120, 81470254), International S&T Cooperation Program of China (2013DFA30870), the 111 Project (B13016), and the US National Institutes of Health (NIH) NIAID UO1, 1U01AI09090. The computations involved in this study were supported by Fudan University High-End Computing Center. Mr. Xiong was supported by Grant 1R01AR057120–01 and 1R01HL106034-01, from the NIH and the US National Heart, Lung, and Blood Institute. S. Guo, PhD, State Key Laboratory of Genetic Engineering and Ministry of Education Key Laboratory of Contemporary Anthropology, Collaborative Innovation Center for Genetics and Development, School of Life Sciences and Institutes of Biomedical Sciences, Fudan University, and Institute of Rheumatology, Immunology and Allergy, Fudan University; Y. Li, MS, State Key Laboratory of Genetic Engineering and Ministry of Education Key Laboratory of Contemporary Anthropology, Collaborative Innovation Center for Genetics and Development, School of Life Sciences and Institutes of Biomedical Sciences, Fudan University; Y. Wang, PhD, State Key Laboratory of Genetic Engineering and Ministry of Education Key Laboratory of Contemporary Anthropology, Collaborative Innovation Center for Genetics and Development, School of Life Sciences and Institutes of Biomedical Sciences, Fudan University; H. Chu, PhD, State Key Laboratory of Genetic Engineering and Ministry of Education Key Laboratory of Contemporary Anthropology, Collaborative Innovation Center for Genetics and Development, School of Life Sciences and Institutes of Biomedical Sciences, Fudan University; Y. Chen, PhD, State Key Laboratory of Genetic Engineering and Ministry of Education Key Laboratory of Contemporary Anthropology, Collaborative Innovation Center for Genetics and Development, School of Life Sciences and Institutes of Biomedical Sciences, Fudan University; Q. Liu, PhD, State Key Laboratory of Genetic Engineering and Ministry of Education Key Laboratory of Contemporary Anthropology, Collaborative Innovation Center for Genetics and Development, School of Life Sciences and Institutes of Biomedical Sciences, Fudan University; G. Guo, MD, Yiling Hospital; W. Tu, MD, Shanghai TCM-Integrated Hospital; W. Wu, MD, Institute of Rheumatology, Immunology and Allergy, Fudan University, and Division of Dermatology, Huashan Hospital, Fudan University; H. Zou, PhD, MD, Institute of Rheumatology, Immunology and Allergy, Fudan University, and Division of Rheumatology, Huashan Hospital, Fudan University; L. Yang, MD, Division of Rheumatology, Teaching Hospital of Chengdu University of TCM; R. Xiao, MD, Department of Dermatology, Second Xiangya Hospital, Central South University; Y. Ma, MS, State Key Laboratory of Genetic Engineering and Ministry of Education Key Laboratory of Contemporary Anthropology, Collaborative Innovation Center for Genetics and Development, School of Life Sciences and Institutes of Biomedical Sciences, Fudan University; F. Zhang, PhD, State Key Laboratory of Genetic Engineering and Ministry of Education Key Laboratory of Contemporary Anthropology, Collaborative Innovation Center for Genetics and Development, School of Life Sciences and Institutes of Biomedical Sciences, Fudan University; M. Xiong, PhD, School of Public Health, University of Texas; L. Jin, PhD, State Key Laboratory of Genetic Engineering and Ministry of Education Key Laboratory of Contemporary Anthropology, Collaborative Innovation Center for Genetics and Development, School of Life Sciences and Institutes of Biomedical Sciences, Fudan University; X. Zhou, MD, Medical School at Houston, University of Texas; J. Wang, PhD, State Key Laboratory of Genetic Engineering and Ministry of Education Key Laboratory of Contemporary Anthropology, Collaborative Innovation Center for Genetics and Development, School of Life Sciences and Institutes of Biomedical Sciences, Fudan University, and Institute of Rheumatology, Immunology and Allergy, Fudan University. Address correspondence to J. Wang, School of Life Sciences, Fudan University Jiangwan Campus, 2005 Songhu Road, Shanghai 200438, China. E-mail: jcwang@fudan.edu.cn. Accepted for publication January 26, 2016.
Haiyan Chu
From the State Key Laboratory of Genetic Engineering and Ministry of Education Key Laboratory of Contemporary Anthropology, Collaborative Innovation Center for Genetics and Development, School of Life Sciences and Institutes of Biomedical Sciences, Fudan University; Institute of Rheumatology, Immunology and Allergy, Fudan University; Shanghai Traditional Chinese Medicine (TCM)-Integrated Hospital; Division of Dermatology, and Division of Rheumatology, Huashan Hospital, Fudan University, Shanghai; Yiling Hospital, Shijiazhuang; Division of Rheumatology, Teaching Hospital of Chengdu University of TCM, Chengdu; Department of Dermatology, Second Xiangya Hospital, Central South University, Changsha, China; School of Public Health, and Medical School at Houston, University of Texas, Houston, Texas, USA. Supported by research grants from the National Basic Research Program (2012CB944604), National Science Foundation of China (81270120, 81470254), International S&T Cooperation Program of China (2013DFA30870), the 111 Project (B13016), and the US National Institutes of Health (NIH) NIAID UO1, 1U01AI09090. The computations involved in this study were supported by Fudan University High-End Computing Center. Mr. Xiong was supported by Grant 1R01AR057120–01 and 1R01HL106034-01, from the NIH and the US National Heart, Lung, and Blood Institute. S. Guo, PhD, State Key Laboratory of Genetic Engineering and Ministry of Education Key Laboratory of Contemporary Anthropology, Collaborative Innovation Center for Genetics and Development, School of Life Sciences and Institutes of Biomedical Sciences, Fudan University, and Institute of Rheumatology, Immunology and Allergy, Fudan University; Y. Li, MS, State Key Laboratory of Genetic Engineering and Ministry of Education Key Laboratory of Contemporary Anthropology, Collaborative Innovation Center for Genetics and Development, School of Life Sciences and Institutes of Biomedical Sciences, Fudan University; Y. Wang, PhD, State Key Laboratory of Genetic Engineering and Ministry of Education Key Laboratory of Contemporary Anthropology, Collaborative Innovation Center for Genetics and Development, School of Life Sciences and Institutes of Biomedical Sciences, Fudan University; H. Chu, PhD, State Key Laboratory of Genetic Engineering and Ministry of Education Key Laboratory of Contemporary Anthropology, Collaborative Innovation Center for Genetics and Development, School of Life Sciences and Institutes of Biomedical Sciences, Fudan University; Y. Chen, PhD, State Key Laboratory of Genetic Engineering and Ministry of Education Key Laboratory of Contemporary Anthropology, Collaborative Innovation Center for Genetics and Development, School of Life Sciences and Institutes of Biomedical Sciences, Fudan University; Q. Liu, PhD, State Key Laboratory of Genetic Engineering and Ministry of Education Key Laboratory of Contemporary Anthropology, Collaborative Innovation Center for Genetics and Development, School of Life Sciences and Institutes of Biomedical Sciences, Fudan University; G. Guo, MD, Yiling Hospital; W. Tu, MD, Shanghai TCM-Integrated Hospital; W. Wu, MD, Institute of Rheumatology, Immunology and Allergy, Fudan University, and Division of Dermatology, Huashan Hospital, Fudan University; H. Zou, PhD, MD, Institute of Rheumatology, Immunology and Allergy, Fudan University, and Division of Rheumatology, Huashan Hospital, Fudan University; L. Yang, MD, Division of Rheumatology, Teaching Hospital of Chengdu University of TCM; R. Xiao, MD, Department of Dermatology, Second Xiangya Hospital, Central South University; Y. Ma, MS, State Key Laboratory of Genetic Engineering and Ministry of Education Key Laboratory of Contemporary Anthropology, Collaborative Innovation Center for Genetics and Development, School of Life Sciences and Institutes of Biomedical Sciences, Fudan University; F. Zhang, PhD, State Key Laboratory of Genetic Engineering and Ministry of Education Key Laboratory of Contemporary Anthropology, Collaborative Innovation Center for Genetics and Development, School of Life Sciences and Institutes of Biomedical Sciences, Fudan University; M. Xiong, PhD, School of Public Health, University of Texas; L. Jin, PhD, State Key Laboratory of Genetic Engineering and Ministry of Education Key Laboratory of Contemporary Anthropology, Collaborative Innovation Center for Genetics and Development, School of Life Sciences and Institutes of Biomedical Sciences, Fudan University; X. Zhou, MD, Medical School at Houston, University of Texas; J. Wang, PhD, State Key Laboratory of Genetic Engineering and Ministry of Education Key Laboratory of Contemporary Anthropology, Collaborative Innovation Center for Genetics and Development, School of Life Sciences and Institutes of Biomedical Sciences, Fudan University, and Institute of Rheumatology, Immunology and Allergy, Fudan University. Address correspondence to J. Wang, School of Life Sciences, Fudan University Jiangwan Campus, 2005 Songhu Road, Shanghai 200438, China. E-mail: jcwang@fudan.edu.cn. Accepted for publication January 26, 2016.
Yulin Chen
From the State Key Laboratory of Genetic Engineering and Ministry of Education Key Laboratory of Contemporary Anthropology, Collaborative Innovation Center for Genetics and Development, School of Life Sciences and Institutes of Biomedical Sciences, Fudan University; Institute of Rheumatology, Immunology and Allergy, Fudan University; Shanghai Traditional Chinese Medicine (TCM)-Integrated Hospital; Division of Dermatology, and Division of Rheumatology, Huashan Hospital, Fudan University, Shanghai; Yiling Hospital, Shijiazhuang; Division of Rheumatology, Teaching Hospital of Chengdu University of TCM, Chengdu; Department of Dermatology, Second Xiangya Hospital, Central South University, Changsha, China; School of Public Health, and Medical School at Houston, University of Texas, Houston, Texas, USA. Supported by research grants from the National Basic Research Program (2012CB944604), National Science Foundation of China (81270120, 81470254), International S&T Cooperation Program of China (2013DFA30870), the 111 Project (B13016), and the US National Institutes of Health (NIH) NIAID UO1, 1U01AI09090. The computations involved in this study were supported by Fudan University High-End Computing Center. Mr. Xiong was supported by Grant 1R01AR057120–01 and 1R01HL106034-01, from the NIH and the US National Heart, Lung, and Blood Institute. S. Guo, PhD, State Key Laboratory of Genetic Engineering and Ministry of Education Key Laboratory of Contemporary Anthropology, Collaborative Innovation Center for Genetics and Development, School of Life Sciences and Institutes of Biomedical Sciences, Fudan University, and Institute of Rheumatology, Immunology and Allergy, Fudan University; Y. Li, MS, State Key Laboratory of Genetic Engineering and Ministry of Education Key Laboratory of Contemporary Anthropology, Collaborative Innovation Center for Genetics and Development, School of Life Sciences and Institutes of Biomedical Sciences, Fudan University; Y. Wang, PhD, State Key Laboratory of Genetic Engineering and Ministry of Education Key Laboratory of Contemporary Anthropology, Collaborative Innovation Center for Genetics and Development, School of Life Sciences and Institutes of Biomedical Sciences, Fudan University; H. Chu, PhD, State Key Laboratory of Genetic Engineering and Ministry of Education Key Laboratory of Contemporary Anthropology, Collaborative Innovation Center for Genetics and Development, School of Life Sciences and Institutes of Biomedical Sciences, Fudan University; Y. Chen, PhD, State Key Laboratory of Genetic Engineering and Ministry of Education Key Laboratory of Contemporary Anthropology, Collaborative Innovation Center for Genetics and Development, School of Life Sciences and Institutes of Biomedical Sciences, Fudan University; Q. Liu, PhD, State Key Laboratory of Genetic Engineering and Ministry of Education Key Laboratory of Contemporary Anthropology, Collaborative Innovation Center for Genetics and Development, School of Life Sciences and Institutes of Biomedical Sciences, Fudan University; G. Guo, MD, Yiling Hospital; W. Tu, MD, Shanghai TCM-Integrated Hospital; W. Wu, MD, Institute of Rheumatology, Immunology and Allergy, Fudan University, and Division of Dermatology, Huashan Hospital, Fudan University; H. Zou, PhD, MD, Institute of Rheumatology, Immunology and Allergy, Fudan University, and Division of Rheumatology, Huashan Hospital, Fudan University; L. Yang, MD, Division of Rheumatology, Teaching Hospital of Chengdu University of TCM; R. Xiao, MD, Department of Dermatology, Second Xiangya Hospital, Central South University; Y. Ma, MS, State Key Laboratory of Genetic Engineering and Ministry of Education Key Laboratory of Contemporary Anthropology, Collaborative Innovation Center for Genetics and Development, School of Life Sciences and Institutes of Biomedical Sciences, Fudan University; F. Zhang, PhD, State Key Laboratory of Genetic Engineering and Ministry of Education Key Laboratory of Contemporary Anthropology, Collaborative Innovation Center for Genetics and Development, School of Life Sciences and Institutes of Biomedical Sciences, Fudan University; M. Xiong, PhD, School of Public Health, University of Texas; L. Jin, PhD, State Key Laboratory of Genetic Engineering and Ministry of Education Key Laboratory of Contemporary Anthropology, Collaborative Innovation Center for Genetics and Development, School of Life Sciences and Institutes of Biomedical Sciences, Fudan University; X. Zhou, MD, Medical School at Houston, University of Texas; J. Wang, PhD, State Key Laboratory of Genetic Engineering and Ministry of Education Key Laboratory of Contemporary Anthropology, Collaborative Innovation Center for Genetics and Development, School of Life Sciences and Institutes of Biomedical Sciences, Fudan University, and Institute of Rheumatology, Immunology and Allergy, Fudan University. Address correspondence to J. Wang, School of Life Sciences, Fudan University Jiangwan Campus, 2005 Songhu Road, Shanghai 200438, China. E-mail: jcwang@fudan.edu.cn. Accepted for publication January 26, 2016.
Qingmei Liu
From the State Key Laboratory of Genetic Engineering and Ministry of Education Key Laboratory of Contemporary Anthropology, Collaborative Innovation Center for Genetics and Development, School of Life Sciences and Institutes of Biomedical Sciences, Fudan University; Institute of Rheumatology, Immunology and Allergy, Fudan University; Shanghai Traditional Chinese Medicine (TCM)-Integrated Hospital; Division of Dermatology, and Division of Rheumatology, Huashan Hospital, Fudan University, Shanghai; Yiling Hospital, Shijiazhuang; Division of Rheumatology, Teaching Hospital of Chengdu University of TCM, Chengdu; Department of Dermatology, Second Xiangya Hospital, Central South University, Changsha, China; School of Public Health, and Medical School at Houston, University of Texas, Houston, Texas, USA. Supported by research grants from the National Basic Research Program (2012CB944604), National Science Foundation of China (81270120, 81470254), International S&T Cooperation Program of China (2013DFA30870), the 111 Project (B13016), and the US National Institutes of Health (NIH) NIAID UO1, 1U01AI09090. The computations involved in this study were supported by Fudan University High-End Computing Center. Mr. Xiong was supported by Grant 1R01AR057120–01 and 1R01HL106034-01, from the NIH and the US National Heart, Lung, and Blood Institute. S. Guo, PhD, State Key Laboratory of Genetic Engineering and Ministry of Education Key Laboratory of Contemporary Anthropology, Collaborative Innovation Center for Genetics and Development, School of Life Sciences and Institutes of Biomedical Sciences, Fudan University, and Institute of Rheumatology, Immunology and Allergy, Fudan University; Y. Li, MS, State Key Laboratory of Genetic Engineering and Ministry of Education Key Laboratory of Contemporary Anthropology, Collaborative Innovation Center for Genetics and Development, School of Life Sciences and Institutes of Biomedical Sciences, Fudan University; Y. Wang, PhD, State Key Laboratory of Genetic Engineering and Ministry of Education Key Laboratory of Contemporary Anthropology, Collaborative Innovation Center for Genetics and Development, School of Life Sciences and Institutes of Biomedical Sciences, Fudan University; H. Chu, PhD, State Key Laboratory of Genetic Engineering and Ministry of Education Key Laboratory of Contemporary Anthropology, Collaborative Innovation Center for Genetics and Development, School of Life Sciences and Institutes of Biomedical Sciences, Fudan University; Y. Chen, PhD, State Key Laboratory of Genetic Engineering and Ministry of Education Key Laboratory of Contemporary Anthropology, Collaborative Innovation Center for Genetics and Development, School of Life Sciences and Institutes of Biomedical Sciences, Fudan University; Q. Liu, PhD, State Key Laboratory of Genetic Engineering and Ministry of Education Key Laboratory of Contemporary Anthropology, Collaborative Innovation Center for Genetics and Development, School of Life Sciences and Institutes of Biomedical Sciences, Fudan University; G. Guo, MD, Yiling Hospital; W. Tu, MD, Shanghai TCM-Integrated Hospital; W. Wu, MD, Institute of Rheumatology, Immunology and Allergy, Fudan University, and Division of Dermatology, Huashan Hospital, Fudan University; H. Zou, PhD, MD, Institute of Rheumatology, Immunology and Allergy, Fudan University, and Division of Rheumatology, Huashan Hospital, Fudan University; L. Yang, MD, Division of Rheumatology, Teaching Hospital of Chengdu University of TCM; R. Xiao, MD, Department of Dermatology, Second Xiangya Hospital, Central South University; Y. Ma, MS, State Key Laboratory of Genetic Engineering and Ministry of Education Key Laboratory of Contemporary Anthropology, Collaborative Innovation Center for Genetics and Development, School of Life Sciences and Institutes of Biomedical Sciences, Fudan University; F. Zhang, PhD, State Key Laboratory of Genetic Engineering and Ministry of Education Key Laboratory of Contemporary Anthropology, Collaborative Innovation Center for Genetics and Development, School of Life Sciences and Institutes of Biomedical Sciences, Fudan University; M. Xiong, PhD, School of Public Health, University of Texas; L. Jin, PhD, State Key Laboratory of Genetic Engineering and Ministry of Education Key Laboratory of Contemporary Anthropology, Collaborative Innovation Center for Genetics and Development, School of Life Sciences and Institutes of Biomedical Sciences, Fudan University; X. Zhou, MD, Medical School at Houston, University of Texas; J. Wang, PhD, State Key Laboratory of Genetic Engineering and Ministry of Education Key Laboratory of Contemporary Anthropology, Collaborative Innovation Center for Genetics and Development, School of Life Sciences and Institutes of Biomedical Sciences, Fudan University, and Institute of Rheumatology, Immunology and Allergy, Fudan University. Address correspondence to J. Wang, School of Life Sciences, Fudan University Jiangwan Campus, 2005 Songhu Road, Shanghai 200438, China. E-mail: jcwang@fudan.edu.cn. Accepted for publication January 26, 2016.
Gang Guo
From the State Key Laboratory of Genetic Engineering and Ministry of Education Key Laboratory of Contemporary Anthropology, Collaborative Innovation Center for Genetics and Development, School of Life Sciences and Institutes of Biomedical Sciences, Fudan University; Institute of Rheumatology, Immunology and Allergy, Fudan University; Shanghai Traditional Chinese Medicine (TCM)-Integrated Hospital; Division of Dermatology, and Division of Rheumatology, Huashan Hospital, Fudan University, Shanghai; Yiling Hospital, Shijiazhuang; Division of Rheumatology, Teaching Hospital of Chengdu University of TCM, Chengdu; Department of Dermatology, Second Xiangya Hospital, Central South University, Changsha, China; School of Public Health, and Medical School at Houston, University of Texas, Houston, Texas, USA. Supported by research grants from the National Basic Research Program (2012CB944604), National Science Foundation of China (81270120, 81470254), International S&T Cooperation Program of China (2013DFA30870), the 111 Project (B13016), and the US National Institutes of Health (NIH) NIAID UO1, 1U01AI09090. The computations involved in this study were supported by Fudan University High-End Computing Center. Mr. Xiong was supported by Grant 1R01AR057120–01 and 1R01HL106034-01, from the NIH and the US National Heart, Lung, and Blood Institute. S. Guo, PhD, State Key Laboratory of Genetic Engineering and Ministry of Education Key Laboratory of Contemporary Anthropology, Collaborative Innovation Center for Genetics and Development, School of Life Sciences and Institutes of Biomedical Sciences, Fudan University, and Institute of Rheumatology, Immunology and Allergy, Fudan University; Y. Li, MS, State Key Laboratory of Genetic Engineering and Ministry of Education Key Laboratory of Contemporary Anthropology, Collaborative Innovation Center for Genetics and Development, School of Life Sciences and Institutes of Biomedical Sciences, Fudan University; Y. Wang, PhD, State Key Laboratory of Genetic Engineering and Ministry of Education Key Laboratory of Contemporary Anthropology, Collaborative Innovation Center for Genetics and Development, School of Life Sciences and Institutes of Biomedical Sciences, Fudan University; H. Chu, PhD, State Key Laboratory of Genetic Engineering and Ministry of Education Key Laboratory of Contemporary Anthropology, Collaborative Innovation Center for Genetics and Development, School of Life Sciences and Institutes of Biomedical Sciences, Fudan University; Y. Chen, PhD, State Key Laboratory of Genetic Engineering and Ministry of Education Key Laboratory of Contemporary Anthropology, Collaborative Innovation Center for Genetics and Development, School of Life Sciences and Institutes of Biomedical Sciences, Fudan University; Q. Liu, PhD, State Key Laboratory of Genetic Engineering and Ministry of Education Key Laboratory of Contemporary Anthropology, Collaborative Innovation Center for Genetics and Development, School of Life Sciences and Institutes of Biomedical Sciences, Fudan University; G. Guo, MD, Yiling Hospital; W. Tu, MD, Shanghai TCM-Integrated Hospital; W. Wu, MD, Institute of Rheumatology, Immunology and Allergy, Fudan University, and Division of Dermatology, Huashan Hospital, Fudan University; H. Zou, PhD, MD, Institute of Rheumatology, Immunology and Allergy, Fudan University, and Division of Rheumatology, Huashan Hospital, Fudan University; L. Yang, MD, Division of Rheumatology, Teaching Hospital of Chengdu University of TCM; R. Xiao, MD, Department of Dermatology, Second Xiangya Hospital, Central South University; Y. Ma, MS, State Key Laboratory of Genetic Engineering and Ministry of Education Key Laboratory of Contemporary Anthropology, Collaborative Innovation Center for Genetics and Development, School of Life Sciences and Institutes of Biomedical Sciences, Fudan University; F. Zhang, PhD, State Key Laboratory of Genetic Engineering and Ministry of Education Key Laboratory of Contemporary Anthropology, Collaborative Innovation Center for Genetics and Development, School of Life Sciences and Institutes of Biomedical Sciences, Fudan University; M. Xiong, PhD, School of Public Health, University of Texas; L. Jin, PhD, State Key Laboratory of Genetic Engineering and Ministry of Education Key Laboratory of Contemporary Anthropology, Collaborative Innovation Center for Genetics and Development, School of Life Sciences and Institutes of Biomedical Sciences, Fudan University; X. Zhou, MD, Medical School at Houston, University of Texas; J. Wang, PhD, State Key Laboratory of Genetic Engineering and Ministry of Education Key Laboratory of Contemporary Anthropology, Collaborative Innovation Center for Genetics and Development, School of Life Sciences and Institutes of Biomedical Sciences, Fudan University, and Institute of Rheumatology, Immunology and Allergy, Fudan University. Address correspondence to J. Wang, School of Life Sciences, Fudan University Jiangwan Campus, 2005 Songhu Road, Shanghai 200438, China. E-mail: jcwang@fudan.edu.cn. Accepted for publication January 26, 2016.
Wenzhen Tu
From the State Key Laboratory of Genetic Engineering and Ministry of Education Key Laboratory of Contemporary Anthropology, Collaborative Innovation Center for Genetics and Development, School of Life Sciences and Institutes of Biomedical Sciences, Fudan University; Institute of Rheumatology, Immunology and Allergy, Fudan University; Shanghai Traditional Chinese Medicine (TCM)-Integrated Hospital; Division of Dermatology, and Division of Rheumatology, Huashan Hospital, Fudan University, Shanghai; Yiling Hospital, Shijiazhuang; Division of Rheumatology, Teaching Hospital of Chengdu University of TCM, Chengdu; Department of Dermatology, Second Xiangya Hospital, Central South University, Changsha, China; School of Public Health, and Medical School at Houston, University of Texas, Houston, Texas, USA. Supported by research grants from the National Basic Research Program (2012CB944604), National Science Foundation of China (81270120, 81470254), International S&T Cooperation Program of China (2013DFA30870), the 111 Project (B13016), and the US National Institutes of Health (NIH) NIAID UO1, 1U01AI09090. The computations involved in this study were supported by Fudan University High-End Computing Center. Mr. Xiong was supported by Grant 1R01AR057120–01 and 1R01HL106034-01, from the NIH and the US National Heart, Lung, and Blood Institute. S. Guo, PhD, State Key Laboratory of Genetic Engineering and Ministry of Education Key Laboratory of Contemporary Anthropology, Collaborative Innovation Center for Genetics and Development, School of Life Sciences and Institutes of Biomedical Sciences, Fudan University, and Institute of Rheumatology, Immunology and Allergy, Fudan University; Y. Li, MS, State Key Laboratory of Genetic Engineering and Ministry of Education Key Laboratory of Contemporary Anthropology, Collaborative Innovation Center for Genetics and Development, School of Life Sciences and Institutes of Biomedical Sciences, Fudan University; Y. Wang, PhD, State Key Laboratory of Genetic Engineering and Ministry of Education Key Laboratory of Contemporary Anthropology, Collaborative Innovation Center for Genetics and Development, School of Life Sciences and Institutes of Biomedical Sciences, Fudan University; H. Chu, PhD, State Key Laboratory of Genetic Engineering and Ministry of Education Key Laboratory of Contemporary Anthropology, Collaborative Innovation Center for Genetics and Development, School of Life Sciences and Institutes of Biomedical Sciences, Fudan University; Y. Chen, PhD, State Key Laboratory of Genetic Engineering and Ministry of Education Key Laboratory of Contemporary Anthropology, Collaborative Innovation Center for Genetics and Development, School of Life Sciences and Institutes of Biomedical Sciences, Fudan University; Q. Liu, PhD, State Key Laboratory of Genetic Engineering and Ministry of Education Key Laboratory of Contemporary Anthropology, Collaborative Innovation Center for Genetics and Development, School of Life Sciences and Institutes of Biomedical Sciences, Fudan University; G. Guo, MD, Yiling Hospital; W. Tu, MD, Shanghai TCM-Integrated Hospital; W. Wu, MD, Institute of Rheumatology, Immunology and Allergy, Fudan University, and Division of Dermatology, Huashan Hospital, Fudan University; H. Zou, PhD, MD, Institute of Rheumatology, Immunology and Allergy, Fudan University, and Division of Rheumatology, Huashan Hospital, Fudan University; L. Yang, MD, Division of Rheumatology, Teaching Hospital of Chengdu University of TCM; R. Xiao, MD, Department of Dermatology, Second Xiangya Hospital, Central South University; Y. Ma, MS, State Key Laboratory of Genetic Engineering and Ministry of Education Key Laboratory of Contemporary Anthropology, Collaborative Innovation Center for Genetics and Development, School of Life Sciences and Institutes of Biomedical Sciences, Fudan University; F. Zhang, PhD, State Key Laboratory of Genetic Engineering and Ministry of Education Key Laboratory of Contemporary Anthropology, Collaborative Innovation Center for Genetics and Development, School of Life Sciences and Institutes of Biomedical Sciences, Fudan University; M. Xiong, PhD, School of Public Health, University of Texas; L. Jin, PhD, State Key Laboratory of Genetic Engineering and Ministry of Education Key Laboratory of Contemporary Anthropology, Collaborative Innovation Center for Genetics and Development, School of Life Sciences and Institutes of Biomedical Sciences, Fudan University; X. Zhou, MD, Medical School at Houston, University of Texas; J. Wang, PhD, State Key Laboratory of Genetic Engineering and Ministry of Education Key Laboratory of Contemporary Anthropology, Collaborative Innovation Center for Genetics and Development, School of Life Sciences and Institutes of Biomedical Sciences, Fudan University, and Institute of Rheumatology, Immunology and Allergy, Fudan University. Address correspondence to J. Wang, School of Life Sciences, Fudan University Jiangwan Campus, 2005 Songhu Road, Shanghai 200438, China. E-mail: jcwang@fudan.edu.cn. Accepted for publication January 26, 2016.
Wenyu Wu
From the State Key Laboratory of Genetic Engineering and Ministry of Education Key Laboratory of Contemporary Anthropology, Collaborative Innovation Center for Genetics and Development, School of Life Sciences and Institutes of Biomedical Sciences, Fudan University; Institute of Rheumatology, Immunology and Allergy, Fudan University; Shanghai Traditional Chinese Medicine (TCM)-Integrated Hospital; Division of Dermatology, and Division of Rheumatology, Huashan Hospital, Fudan University, Shanghai; Yiling Hospital, Shijiazhuang; Division of Rheumatology, Teaching Hospital of Chengdu University of TCM, Chengdu; Department of Dermatology, Second Xiangya Hospital, Central South University, Changsha, China; School of Public Health, and Medical School at Houston, University of Texas, Houston, Texas, USA. Supported by research grants from the National Basic Research Program (2012CB944604), National Science Foundation of China (81270120, 81470254), International S&T Cooperation Program of China (2013DFA30870), the 111 Project (B13016), and the US National Institutes of Health (NIH) NIAID UO1, 1U01AI09090. The computations involved in this study were supported by Fudan University High-End Computing Center. Mr. Xiong was supported by Grant 1R01AR057120–01 and 1R01HL106034-01, from the NIH and the US National Heart, Lung, and Blood Institute. S. Guo, PhD, State Key Laboratory of Genetic Engineering and Ministry of Education Key Laboratory of Contemporary Anthropology, Collaborative Innovation Center for Genetics and Development, School of Life Sciences and Institutes of Biomedical Sciences, Fudan University, and Institute of Rheumatology, Immunology and Allergy, Fudan University; Y. Li, MS, State Key Laboratory of Genetic Engineering and Ministry of Education Key Laboratory of Contemporary Anthropology, Collaborative Innovation Center for Genetics and Development, School of Life Sciences and Institutes of Biomedical Sciences, Fudan University; Y. Wang, PhD, State Key Laboratory of Genetic Engineering and Ministry of Education Key Laboratory of Contemporary Anthropology, Collaborative Innovation Center for Genetics and Development, School of Life Sciences and Institutes of Biomedical Sciences, Fudan University; H. Chu, PhD, State Key Laboratory of Genetic Engineering and Ministry of Education Key Laboratory of Contemporary Anthropology, Collaborative Innovation Center for Genetics and Development, School of Life Sciences and Institutes of Biomedical Sciences, Fudan University; Y. Chen, PhD, State Key Laboratory of Genetic Engineering and Ministry of Education Key Laboratory of Contemporary Anthropology, Collaborative Innovation Center for Genetics and Development, School of Life Sciences and Institutes of Biomedical Sciences, Fudan University; Q. Liu, PhD, State Key Laboratory of Genetic Engineering and Ministry of Education Key Laboratory of Contemporary Anthropology, Collaborative Innovation Center for Genetics and Development, School of Life Sciences and Institutes of Biomedical Sciences, Fudan University; G. Guo, MD, Yiling Hospital; W. Tu, MD, Shanghai TCM-Integrated Hospital; W. Wu, MD, Institute of Rheumatology, Immunology and Allergy, Fudan University, and Division of Dermatology, Huashan Hospital, Fudan University; H. Zou, PhD, MD, Institute of Rheumatology, Immunology and Allergy, Fudan University, and Division of Rheumatology, Huashan Hospital, Fudan University; L. Yang, MD, Division of Rheumatology, Teaching Hospital of Chengdu University of TCM; R. Xiao, MD, Department of Dermatology, Second Xiangya Hospital, Central South University; Y. Ma, MS, State Key Laboratory of Genetic Engineering and Ministry of Education Key Laboratory of Contemporary Anthropology, Collaborative Innovation Center for Genetics and Development, School of Life Sciences and Institutes of Biomedical Sciences, Fudan University; F. Zhang, PhD, State Key Laboratory of Genetic Engineering and Ministry of Education Key Laboratory of Contemporary Anthropology, Collaborative Innovation Center for Genetics and Development, School of Life Sciences and Institutes of Biomedical Sciences, Fudan University; M. Xiong, PhD, School of Public Health, University of Texas; L. Jin, PhD, State Key Laboratory of Genetic Engineering and Ministry of Education Key Laboratory of Contemporary Anthropology, Collaborative Innovation Center for Genetics and Development, School of Life Sciences and Institutes of Biomedical Sciences, Fudan University; X. Zhou, MD, Medical School at Houston, University of Texas; J. Wang, PhD, State Key Laboratory of Genetic Engineering and Ministry of Education Key Laboratory of Contemporary Anthropology, Collaborative Innovation Center for Genetics and Development, School of Life Sciences and Institutes of Biomedical Sciences, Fudan University, and Institute of Rheumatology, Immunology and Allergy, Fudan University. Address correspondence to J. Wang, School of Life Sciences, Fudan University Jiangwan Campus, 2005 Songhu Road, Shanghai 200438, China. E-mail: jcwang@fudan.edu.cn. Accepted for publication January 26, 2016.
Hejian Zou
From the State Key Laboratory of Genetic Engineering and Ministry of Education Key Laboratory of Contemporary Anthropology, Collaborative Innovation Center for Genetics and Development, School of Life Sciences and Institutes of Biomedical Sciences, Fudan University; Institute of Rheumatology, Immunology and Allergy, Fudan University; Shanghai Traditional Chinese Medicine (TCM)-Integrated Hospital; Division of Dermatology, and Division of Rheumatology, Huashan Hospital, Fudan University, Shanghai; Yiling Hospital, Shijiazhuang; Division of Rheumatology, Teaching Hospital of Chengdu University of TCM, Chengdu; Department of Dermatology, Second Xiangya Hospital, Central South University, Changsha, China; School of Public Health, and Medical School at Houston, University of Texas, Houston, Texas, USA. Supported by research grants from the National Basic Research Program (2012CB944604), National Science Foundation of China (81270120, 81470254), International S&T Cooperation Program of China (2013DFA30870), the 111 Project (B13016), and the US National Institutes of Health (NIH) NIAID UO1, 1U01AI09090. The computations involved in this study were supported by Fudan University High-End Computing Center. Mr. Xiong was supported by Grant 1R01AR057120–01 and 1R01HL106034-01, from the NIH and the US National Heart, Lung, and Blood Institute. S. Guo, PhD, State Key Laboratory of Genetic Engineering and Ministry of Education Key Laboratory of Contemporary Anthropology, Collaborative Innovation Center for Genetics and Development, School of Life Sciences and Institutes of Biomedical Sciences, Fudan University, and Institute of Rheumatology, Immunology and Allergy, Fudan University; Y. Li, MS, State Key Laboratory of Genetic Engineering and Ministry of Education Key Laboratory of Contemporary Anthropology, Collaborative Innovation Center for Genetics and Development, School of Life Sciences and Institutes of Biomedical Sciences, Fudan University; Y. Wang, PhD, State Key Laboratory of Genetic Engineering and Ministry of Education Key Laboratory of Contemporary Anthropology, Collaborative Innovation Center for Genetics and Development, School of Life Sciences and Institutes of Biomedical Sciences, Fudan University; H. Chu, PhD, State Key Laboratory of Genetic Engineering and Ministry of Education Key Laboratory of Contemporary Anthropology, Collaborative Innovation Center for Genetics and Development, School of Life Sciences and Institutes of Biomedical Sciences, Fudan University; Y. Chen, PhD, State Key Laboratory of Genetic Engineering and Ministry of Education Key Laboratory of Contemporary Anthropology, Collaborative Innovation Center for Genetics and Development, School of Life Sciences and Institutes of Biomedical Sciences, Fudan University; Q. Liu, PhD, State Key Laboratory of Genetic Engineering and Ministry of Education Key Laboratory of Contemporary Anthropology, Collaborative Innovation Center for Genetics and Development, School of Life Sciences and Institutes of Biomedical Sciences, Fudan University; G. Guo, MD, Yiling Hospital; W. Tu, MD, Shanghai TCM-Integrated Hospital; W. Wu, MD, Institute of Rheumatology, Immunology and Allergy, Fudan University, and Division of Dermatology, Huashan Hospital, Fudan University; H. Zou, PhD, MD, Institute of Rheumatology, Immunology and Allergy, Fudan University, and Division of Rheumatology, Huashan Hospital, Fudan University; L. Yang, MD, Division of Rheumatology, Teaching Hospital of Chengdu University of TCM; R. Xiao, MD, Department of Dermatology, Second Xiangya Hospital, Central South University; Y. Ma, MS, State Key Laboratory of Genetic Engineering and Ministry of Education Key Laboratory of Contemporary Anthropology, Collaborative Innovation Center for Genetics and Development, School of Life Sciences and Institutes of Biomedical Sciences, Fudan University; F. Zhang, PhD, State Key Laboratory of Genetic Engineering and Ministry of Education Key Laboratory of Contemporary Anthropology, Collaborative Innovation Center for Genetics and Development, School of Life Sciences and Institutes of Biomedical Sciences, Fudan University; M. Xiong, PhD, School of Public Health, University of Texas; L. Jin, PhD, State Key Laboratory of Genetic Engineering and Ministry of Education Key Laboratory of Contemporary Anthropology, Collaborative Innovation Center for Genetics and Development, School of Life Sciences and Institutes of Biomedical Sciences, Fudan University; X. Zhou, MD, Medical School at Houston, University of Texas; J. Wang, PhD, State Key Laboratory of Genetic Engineering and Ministry of Education Key Laboratory of Contemporary Anthropology, Collaborative Innovation Center for Genetics and Development, School of Life Sciences and Institutes of Biomedical Sciences, Fudan University, and Institute of Rheumatology, Immunology and Allergy, Fudan University. Address correspondence to J. Wang, School of Life Sciences, Fudan University Jiangwan Campus, 2005 Songhu Road, Shanghai 200438, China. E-mail: jcwang@fudan.edu.cn. Accepted for publication January 26, 2016.
Li Yang
From the State Key Laboratory of Genetic Engineering and Ministry of Education Key Laboratory of Contemporary Anthropology, Collaborative Innovation Center for Genetics and Development, School of Life Sciences and Institutes of Biomedical Sciences, Fudan University; Institute of Rheumatology, Immunology and Allergy, Fudan University; Shanghai Traditional Chinese Medicine (TCM)-Integrated Hospital; Division of Dermatology, and Division of Rheumatology, Huashan Hospital, Fudan University, Shanghai; Yiling Hospital, Shijiazhuang; Division of Rheumatology, Teaching Hospital of Chengdu University of TCM, Chengdu; Department of Dermatology, Second Xiangya Hospital, Central South University, Changsha, China; School of Public Health, and Medical School at Houston, University of Texas, Houston, Texas, USA. Supported by research grants from the National Basic Research Program (2012CB944604), National Science Foundation of China (81270120, 81470254), International S&T Cooperation Program of China (2013DFA30870), the 111 Project (B13016), and the US National Institutes of Health (NIH) NIAID UO1, 1U01AI09090. The computations involved in this study were supported by Fudan University High-End Computing Center. Mr. Xiong was supported by Grant 1R01AR057120–01 and 1R01HL106034-01, from the NIH and the US National Heart, Lung, and Blood Institute. S. Guo, PhD, State Key Laboratory of Genetic Engineering and Ministry of Education Key Laboratory of Contemporary Anthropology, Collaborative Innovation Center for Genetics and Development, School of Life Sciences and Institutes of Biomedical Sciences, Fudan University, and Institute of Rheumatology, Immunology and Allergy, Fudan University; Y. Li, MS, State Key Laboratory of Genetic Engineering and Ministry of Education Key Laboratory of Contemporary Anthropology, Collaborative Innovation Center for Genetics and Development, School of Life Sciences and Institutes of Biomedical Sciences, Fudan University; Y. Wang, PhD, State Key Laboratory of Genetic Engineering and Ministry of Education Key Laboratory of Contemporary Anthropology, Collaborative Innovation Center for Genetics and Development, School of Life Sciences and Institutes of Biomedical Sciences, Fudan University; H. Chu, PhD, State Key Laboratory of Genetic Engineering and Ministry of Education Key Laboratory of Contemporary Anthropology, Collaborative Innovation Center for Genetics and Development, School of Life Sciences and Institutes of Biomedical Sciences, Fudan University; Y. Chen, PhD, State Key Laboratory of Genetic Engineering and Ministry of Education Key Laboratory of Contemporary Anthropology, Collaborative Innovation Center for Genetics and Development, School of Life Sciences and Institutes of Biomedical Sciences, Fudan University; Q. Liu, PhD, State Key Laboratory of Genetic Engineering and Ministry of Education Key Laboratory of Contemporary Anthropology, Collaborative Innovation Center for Genetics and Development, School of Life Sciences and Institutes of Biomedical Sciences, Fudan University; G. Guo, MD, Yiling Hospital; W. Tu, MD, Shanghai TCM-Integrated Hospital; W. Wu, MD, Institute of Rheumatology, Immunology and Allergy, Fudan University, and Division of Dermatology, Huashan Hospital, Fudan University; H. Zou, PhD, MD, Institute of Rheumatology, Immunology and Allergy, Fudan University, and Division of Rheumatology, Huashan Hospital, Fudan University; L. Yang, MD, Division of Rheumatology, Teaching Hospital of Chengdu University of TCM; R. Xiao, MD, Department of Dermatology, Second Xiangya Hospital, Central South University; Y. Ma, MS, State Key Laboratory of Genetic Engineering and Ministry of Education Key Laboratory of Contemporary Anthropology, Collaborative Innovation Center for Genetics and Development, School of Life Sciences and Institutes of Biomedical Sciences, Fudan University; F. Zhang, PhD, State Key Laboratory of Genetic Engineering and Ministry of Education Key Laboratory of Contemporary Anthropology, Collaborative Innovation Center for Genetics and Development, School of Life Sciences and Institutes of Biomedical Sciences, Fudan University; M. Xiong, PhD, School of Public Health, University of Texas; L. Jin, PhD, State Key Laboratory of Genetic Engineering and Ministry of Education Key Laboratory of Contemporary Anthropology, Collaborative Innovation Center for Genetics and Development, School of Life Sciences and Institutes of Biomedical Sciences, Fudan University; X. Zhou, MD, Medical School at Houston, University of Texas; J. Wang, PhD, State Key Laboratory of Genetic Engineering and Ministry of Education Key Laboratory of Contemporary Anthropology, Collaborative Innovation Center for Genetics and Development, School of Life Sciences and Institutes of Biomedical Sciences, Fudan University, and Institute of Rheumatology, Immunology and Allergy, Fudan University. Address correspondence to J. Wang, School of Life Sciences, Fudan University Jiangwan Campus, 2005 Songhu Road, Shanghai 200438, China. E-mail: jcwang@fudan.edu.cn. Accepted for publication January 26, 2016.
Rong Xiao
From the State Key Laboratory of Genetic Engineering and Ministry of Education Key Laboratory of Contemporary Anthropology, Collaborative Innovation Center for Genetics and Development, School of Life Sciences and Institutes of Biomedical Sciences, Fudan University; Institute of Rheumatology, Immunology and Allergy, Fudan University; Shanghai Traditional Chinese Medicine (TCM)-Integrated Hospital; Division of Dermatology, and Division of Rheumatology, Huashan Hospital, Fudan University, Shanghai; Yiling Hospital, Shijiazhuang; Division of Rheumatology, Teaching Hospital of Chengdu University of TCM, Chengdu; Department of Dermatology, Second Xiangya Hospital, Central South University, Changsha, China; School of Public Health, and Medical School at Houston, University of Texas, Houston, Texas, USA. Supported by research grants from the National Basic Research Program (2012CB944604), National Science Foundation of China (81270120, 81470254), International S&T Cooperation Program of China (2013DFA30870), the 111 Project (B13016), and the US National Institutes of Health (NIH) NIAID UO1, 1U01AI09090. The computations involved in this study were supported by Fudan University High-End Computing Center. Mr. Xiong was supported by Grant 1R01AR057120–01 and 1R01HL106034-01, from the NIH and the US National Heart, Lung, and Blood Institute. S. Guo, PhD, State Key Laboratory of Genetic Engineering and Ministry of Education Key Laboratory of Contemporary Anthropology, Collaborative Innovation Center for Genetics and Development, School of Life Sciences and Institutes of Biomedical Sciences, Fudan University, and Institute of Rheumatology, Immunology and Allergy, Fudan University; Y. Li, MS, State Key Laboratory of Genetic Engineering and Ministry of Education Key Laboratory of Contemporary Anthropology, Collaborative Innovation Center for Genetics and Development, School of Life Sciences and Institutes of Biomedical Sciences, Fudan University; Y. Wang, PhD, State Key Laboratory of Genetic Engineering and Ministry of Education Key Laboratory of Contemporary Anthropology, Collaborative Innovation Center for Genetics and Development, School of Life Sciences and Institutes of Biomedical Sciences, Fudan University; H. Chu, PhD, State Key Laboratory of Genetic Engineering and Ministry of Education Key Laboratory of Contemporary Anthropology, Collaborative Innovation Center for Genetics and Development, School of Life Sciences and Institutes of Biomedical Sciences, Fudan University; Y. Chen, PhD, State Key Laboratory of Genetic Engineering and Ministry of Education Key Laboratory of Contemporary Anthropology, Collaborative Innovation Center for Genetics and Development, School of Life Sciences and Institutes of Biomedical Sciences, Fudan University; Q. Liu, PhD, State Key Laboratory of Genetic Engineering and Ministry of Education Key Laboratory of Contemporary Anthropology, Collaborative Innovation Center for Genetics and Development, School of Life Sciences and Institutes of Biomedical Sciences, Fudan University; G. Guo, MD, Yiling Hospital; W. Tu, MD, Shanghai TCM-Integrated Hospital; W. Wu, MD, Institute of Rheumatology, Immunology and Allergy, Fudan University, and Division of Dermatology, Huashan Hospital, Fudan University; H. Zou, PhD, MD, Institute of Rheumatology, Immunology and Allergy, Fudan University, and Division of Rheumatology, Huashan Hospital, Fudan University; L. Yang, MD, Division of Rheumatology, Teaching Hospital of Chengdu University of TCM; R. Xiao, MD, Department of Dermatology, Second Xiangya Hospital, Central South University; Y. Ma, MS, State Key Laboratory of Genetic Engineering and Ministry of Education Key Laboratory of Contemporary Anthropology, Collaborative Innovation Center for Genetics and Development, School of Life Sciences and Institutes of Biomedical Sciences, Fudan University; F. Zhang, PhD, State Key Laboratory of Genetic Engineering and Ministry of Education Key Laboratory of Contemporary Anthropology, Collaborative Innovation Center for Genetics and Development, School of Life Sciences and Institutes of Biomedical Sciences, Fudan University; M. Xiong, PhD, School of Public Health, University of Texas; L. Jin, PhD, State Key Laboratory of Genetic Engineering and Ministry of Education Key Laboratory of Contemporary Anthropology, Collaborative Innovation Center for Genetics and Development, School of Life Sciences and Institutes of Biomedical Sciences, Fudan University; X. Zhou, MD, Medical School at Houston, University of Texas; J. Wang, PhD, State Key Laboratory of Genetic Engineering and Ministry of Education Key Laboratory of Contemporary Anthropology, Collaborative Innovation Center for Genetics and Development, School of Life Sciences and Institutes of Biomedical Sciences, Fudan University, and Institute of Rheumatology, Immunology and Allergy, Fudan University. Address correspondence to J. Wang, School of Life Sciences, Fudan University Jiangwan Campus, 2005 Songhu Road, Shanghai 200438, China. E-mail: jcwang@fudan.edu.cn. Accepted for publication January 26, 2016.
Yanyun Ma
From the State Key Laboratory of Genetic Engineering and Ministry of Education Key Laboratory of Contemporary Anthropology, Collaborative Innovation Center for Genetics and Development, School of Life Sciences and Institutes of Biomedical Sciences, Fudan University; Institute of Rheumatology, Immunology and Allergy, Fudan University; Shanghai Traditional Chinese Medicine (TCM)-Integrated Hospital; Division of Dermatology, and Division of Rheumatology, Huashan Hospital, Fudan University, Shanghai; Yiling Hospital, Shijiazhuang; Division of Rheumatology, Teaching Hospital of Chengdu University of TCM, Chengdu; Department of Dermatology, Second Xiangya Hospital, Central South University, Changsha, China; School of Public Health, and Medical School at Houston, University of Texas, Houston, Texas, USA. Supported by research grants from the National Basic Research Program (2012CB944604), National Science Foundation of China (81270120, 81470254), International S&T Cooperation Program of China (2013DFA30870), the 111 Project (B13016), and the US National Institutes of Health (NIH) NIAID UO1, 1U01AI09090. The computations involved in this study were supported by Fudan University High-End Computing Center. Mr. Xiong was supported by Grant 1R01AR057120–01 and 1R01HL106034-01, from the NIH and the US National Heart, Lung, and Blood Institute. S. Guo, PhD, State Key Laboratory of Genetic Engineering and Ministry of Education Key Laboratory of Contemporary Anthropology, Collaborative Innovation Center for Genetics and Development, School of Life Sciences and Institutes of Biomedical Sciences, Fudan University, and Institute of Rheumatology, Immunology and Allergy, Fudan University; Y. Li, MS, State Key Laboratory of Genetic Engineering and Ministry of Education Key Laboratory of Contemporary Anthropology, Collaborative Innovation Center for Genetics and Development, School of Life Sciences and Institutes of Biomedical Sciences, Fudan University; Y. Wang, PhD, State Key Laboratory of Genetic Engineering and Ministry of Education Key Laboratory of Contemporary Anthropology, Collaborative Innovation Center for Genetics and Development, School of Life Sciences and Institutes of Biomedical Sciences, Fudan University; H. Chu, PhD, State Key Laboratory of Genetic Engineering and Ministry of Education Key Laboratory of Contemporary Anthropology, Collaborative Innovation Center for Genetics and Development, School of Life Sciences and Institutes of Biomedical Sciences, Fudan University; Y. Chen, PhD, State Key Laboratory of Genetic Engineering and Ministry of Education Key Laboratory of Contemporary Anthropology, Collaborative Innovation Center for Genetics and Development, School of Life Sciences and Institutes of Biomedical Sciences, Fudan University; Q. Liu, PhD, State Key Laboratory of Genetic Engineering and Ministry of Education Key Laboratory of Contemporary Anthropology, Collaborative Innovation Center for Genetics and Development, School of Life Sciences and Institutes of Biomedical Sciences, Fudan University; G. Guo, MD, Yiling Hospital; W. Tu, MD, Shanghai TCM-Integrated Hospital; W. Wu, MD, Institute of Rheumatology, Immunology and Allergy, Fudan University, and Division of Dermatology, Huashan Hospital, Fudan University; H. Zou, PhD, MD, Institute of Rheumatology, Immunology and Allergy, Fudan University, and Division of Rheumatology, Huashan Hospital, Fudan University; L. Yang, MD, Division of Rheumatology, Teaching Hospital of Chengdu University of TCM; R. Xiao, MD, Department of Dermatology, Second Xiangya Hospital, Central South University; Y. Ma, MS, State Key Laboratory of Genetic Engineering and Ministry of Education Key Laboratory of Contemporary Anthropology, Collaborative Innovation Center for Genetics and Development, School of Life Sciences and Institutes of Biomedical Sciences, Fudan University; F. Zhang, PhD, State Key Laboratory of Genetic Engineering and Ministry of Education Key Laboratory of Contemporary Anthropology, Collaborative Innovation Center for Genetics and Development, School of Life Sciences and Institutes of Biomedical Sciences, Fudan University; M. Xiong, PhD, School of Public Health, University of Texas; L. Jin, PhD, State Key Laboratory of Genetic Engineering and Ministry of Education Key Laboratory of Contemporary Anthropology, Collaborative Innovation Center for Genetics and Development, School of Life Sciences and Institutes of Biomedical Sciences, Fudan University; X. Zhou, MD, Medical School at Houston, University of Texas; J. Wang, PhD, State Key Laboratory of Genetic Engineering and Ministry of Education Key Laboratory of Contemporary Anthropology, Collaborative Innovation Center for Genetics and Development, School of Life Sciences and Institutes of Biomedical Sciences, Fudan University, and Institute of Rheumatology, Immunology and Allergy, Fudan University. Address correspondence to J. Wang, School of Life Sciences, Fudan University Jiangwan Campus, 2005 Songhu Road, Shanghai 200438, China. E-mail: jcwang@fudan.edu.cn. Accepted for publication January 26, 2016.
Feng Zhang
From the State Key Laboratory of Genetic Engineering and Ministry of Education Key Laboratory of Contemporary Anthropology, Collaborative Innovation Center for Genetics and Development, School of Life Sciences and Institutes of Biomedical Sciences, Fudan University; Institute of Rheumatology, Immunology and Allergy, Fudan University; Shanghai Traditional Chinese Medicine (TCM)-Integrated Hospital; Division of Dermatology, and Division of Rheumatology, Huashan Hospital, Fudan University, Shanghai; Yiling Hospital, Shijiazhuang; Division of Rheumatology, Teaching Hospital of Chengdu University of TCM, Chengdu; Department of Dermatology, Second Xiangya Hospital, Central South University, Changsha, China; School of Public Health, and Medical School at Houston, University of Texas, Houston, Texas, USA. Supported by research grants from the National Basic Research Program (2012CB944604), National Science Foundation of China (81270120, 81470254), International S&T Cooperation Program of China (2013DFA30870), the 111 Project (B13016), and the US National Institutes of Health (NIH) NIAID UO1, 1U01AI09090. The computations involved in this study were supported by Fudan University High-End Computing Center. Mr. Xiong was supported by Grant 1R01AR057120–01 and 1R01HL106034-01, from the NIH and the US National Heart, Lung, and Blood Institute. S. Guo, PhD, State Key Laboratory of Genetic Engineering and Ministry of Education Key Laboratory of Contemporary Anthropology, Collaborative Innovation Center for Genetics and Development, School of Life Sciences and Institutes of Biomedical Sciences, Fudan University, and Institute of Rheumatology, Immunology and Allergy, Fudan University; Y. Li, MS, State Key Laboratory of Genetic Engineering and Ministry of Education Key Laboratory of Contemporary Anthropology, Collaborative Innovation Center for Genetics and Development, School of Life Sciences and Institutes of Biomedical Sciences, Fudan University; Y. Wang, PhD, State Key Laboratory of Genetic Engineering and Ministry of Education Key Laboratory of Contemporary Anthropology, Collaborative Innovation Center for Genetics and Development, School of Life Sciences and Institutes of Biomedical Sciences, Fudan University; H. Chu, PhD, State Key Laboratory of Genetic Engineering and Ministry of Education Key Laboratory of Contemporary Anthropology, Collaborative Innovation Center for Genetics and Development, School of Life Sciences and Institutes of Biomedical Sciences, Fudan University; Y. Chen, PhD, State Key Laboratory of Genetic Engineering and Ministry of Education Key Laboratory of Contemporary Anthropology, Collaborative Innovation Center for Genetics and Development, School of Life Sciences and Institutes of Biomedical Sciences, Fudan University; Q. Liu, PhD, State Key Laboratory of Genetic Engineering and Ministry of Education Key Laboratory of Contemporary Anthropology, Collaborative Innovation Center for Genetics and Development, School of Life Sciences and Institutes of Biomedical Sciences, Fudan University; G. Guo, MD, Yiling Hospital; W. Tu, MD, Shanghai TCM-Integrated Hospital; W. Wu, MD, Institute of Rheumatology, Immunology and Allergy, Fudan University, and Division of Dermatology, Huashan Hospital, Fudan University; H. Zou, PhD, MD, Institute of Rheumatology, Immunology and Allergy, Fudan University, and Division of Rheumatology, Huashan Hospital, Fudan University; L. Yang, MD, Division of Rheumatology, Teaching Hospital of Chengdu University of TCM; R. Xiao, MD, Department of Dermatology, Second Xiangya Hospital, Central South University; Y. Ma, MS, State Key Laboratory of Genetic Engineering and Ministry of Education Key Laboratory of Contemporary Anthropology, Collaborative Innovation Center for Genetics and Development, School of Life Sciences and Institutes of Biomedical Sciences, Fudan University; F. Zhang, PhD, State Key Laboratory of Genetic Engineering and Ministry of Education Key Laboratory of Contemporary Anthropology, Collaborative Innovation Center for Genetics and Development, School of Life Sciences and Institutes of Biomedical Sciences, Fudan University; M. Xiong, PhD, School of Public Health, University of Texas; L. Jin, PhD, State Key Laboratory of Genetic Engineering and Ministry of Education Key Laboratory of Contemporary Anthropology, Collaborative Innovation Center for Genetics and Development, School of Life Sciences and Institutes of Biomedical Sciences, Fudan University; X. Zhou, MD, Medical School at Houston, University of Texas; J. Wang, PhD, State Key Laboratory of Genetic Engineering and Ministry of Education Key Laboratory of Contemporary Anthropology, Collaborative Innovation Center for Genetics and Development, School of Life Sciences and Institutes of Biomedical Sciences, Fudan University, and Institute of Rheumatology, Immunology and Allergy, Fudan University. Address correspondence to J. Wang, School of Life Sciences, Fudan University Jiangwan Campus, 2005 Songhu Road, Shanghai 200438, China. E-mail: jcwang@fudan.edu.cn. Accepted for publication January 26, 2016.
Momiao Xiong
From the State Key Laboratory of Genetic Engineering and Ministry of Education Key Laboratory of Contemporary Anthropology, Collaborative Innovation Center for Genetics and Development, School of Life Sciences and Institutes of Biomedical Sciences, Fudan University; Institute of Rheumatology, Immunology and Allergy, Fudan University; Shanghai Traditional Chinese Medicine (TCM)-Integrated Hospital; Division of Dermatology, and Division of Rheumatology, Huashan Hospital, Fudan University, Shanghai; Yiling Hospital, Shijiazhuang; Division of Rheumatology, Teaching Hospital of Chengdu University of TCM, Chengdu; Department of Dermatology, Second Xiangya Hospital, Central South University, Changsha, China; School of Public Health, and Medical School at Houston, University of Texas, Houston, Texas, USA. Supported by research grants from the National Basic Research Program (2012CB944604), National Science Foundation of China (81270120, 81470254), International S&T Cooperation Program of China (2013DFA30870), the 111 Project (B13016), and the US National Institutes of Health (NIH) NIAID UO1, 1U01AI09090. The computations involved in this study were supported by Fudan University High-End Computing Center. Mr. Xiong was supported by Grant 1R01AR057120–01 and 1R01HL106034-01, from the NIH and the US National Heart, Lung, and Blood Institute. S. Guo, PhD, State Key Laboratory of Genetic Engineering and Ministry of Education Key Laboratory of Contemporary Anthropology, Collaborative Innovation Center for Genetics and Development, School of Life Sciences and Institutes of Biomedical Sciences, Fudan University, and Institute of Rheumatology, Immunology and Allergy, Fudan University; Y. Li, MS, State Key Laboratory of Genetic Engineering and Ministry of Education Key Laboratory of Contemporary Anthropology, Collaborative Innovation Center for Genetics and Development, School of Life Sciences and Institutes of Biomedical Sciences, Fudan University; Y. Wang, PhD, State Key Laboratory of Genetic Engineering and Ministry of Education Key Laboratory of Contemporary Anthropology, Collaborative Innovation Center for Genetics and Development, School of Life Sciences and Institutes of Biomedical Sciences, Fudan University; H. Chu, PhD, State Key Laboratory of Genetic Engineering and Ministry of Education Key Laboratory of Contemporary Anthropology, Collaborative Innovation Center for Genetics and Development, School of Life Sciences and Institutes of Biomedical Sciences, Fudan University; Y. Chen, PhD, State Key Laboratory of Genetic Engineering and Ministry of Education Key Laboratory of Contemporary Anthropology, Collaborative Innovation Center for Genetics and Development, School of Life Sciences and Institutes of Biomedical Sciences, Fudan University; Q. Liu, PhD, State Key Laboratory of Genetic Engineering and Ministry of Education Key Laboratory of Contemporary Anthropology, Collaborative Innovation Center for Genetics and Development, School of Life Sciences and Institutes of Biomedical Sciences, Fudan University; G. Guo, MD, Yiling Hospital; W. Tu, MD, Shanghai TCM-Integrated Hospital; W. Wu, MD, Institute of Rheumatology, Immunology and Allergy, Fudan University, and Division of Dermatology, Huashan Hospital, Fudan University; H. Zou, PhD, MD, Institute of Rheumatology, Immunology and Allergy, Fudan University, and Division of Rheumatology, Huashan Hospital, Fudan University; L. Yang, MD, Division of Rheumatology, Teaching Hospital of Chengdu University of TCM; R. Xiao, MD, Department of Dermatology, Second Xiangya Hospital, Central South University; Y. Ma, MS, State Key Laboratory of Genetic Engineering and Ministry of Education Key Laboratory of Contemporary Anthropology, Collaborative Innovation Center for Genetics and Development, School of Life Sciences and Institutes of Biomedical Sciences, Fudan University; F. Zhang, PhD, State Key Laboratory of Genetic Engineering and Ministry of Education Key Laboratory of Contemporary Anthropology, Collaborative Innovation Center for Genetics and Development, School of Life Sciences and Institutes of Biomedical Sciences, Fudan University; M. Xiong, PhD, School of Public Health, University of Texas; L. Jin, PhD, State Key Laboratory of Genetic Engineering and Ministry of Education Key Laboratory of Contemporary Anthropology, Collaborative Innovation Center for Genetics and Development, School of Life Sciences and Institutes of Biomedical Sciences, Fudan University; X. Zhou, MD, Medical School at Houston, University of Texas; J. Wang, PhD, State Key Laboratory of Genetic Engineering and Ministry of Education Key Laboratory of Contemporary Anthropology, Collaborative Innovation Center for Genetics and Development, School of Life Sciences and Institutes of Biomedical Sciences, Fudan University, and Institute of Rheumatology, Immunology and Allergy, Fudan University. Address correspondence to J. Wang, School of Life Sciences, Fudan University Jiangwan Campus, 2005 Songhu Road, Shanghai 200438, China. E-mail: jcwang@fudan.edu.cn. Accepted for publication January 26, 2016.
Li Jin
From the State Key Laboratory of Genetic Engineering and Ministry of Education Key Laboratory of Contemporary Anthropology, Collaborative Innovation Center for Genetics and Development, School of Life Sciences and Institutes of Biomedical Sciences, Fudan University; Institute of Rheumatology, Immunology and Allergy, Fudan University; Shanghai Traditional Chinese Medicine (TCM)-Integrated Hospital; Division of Dermatology, and Division of Rheumatology, Huashan Hospital, Fudan University, Shanghai; Yiling Hospital, Shijiazhuang; Division of Rheumatology, Teaching Hospital of Chengdu University of TCM, Chengdu; Department of Dermatology, Second Xiangya Hospital, Central South University, Changsha, China; School of Public Health, and Medical School at Houston, University of Texas, Houston, Texas, USA. Supported by research grants from the National Basic Research Program (2012CB944604), National Science Foundation of China (81270120, 81470254), International S&T Cooperation Program of China (2013DFA30870), the 111 Project (B13016), and the US National Institutes of Health (NIH) NIAID UO1, 1U01AI09090. The computations involved in this study were supported by Fudan University High-End Computing Center. Mr. Xiong was supported by Grant 1R01AR057120–01 and 1R01HL106034-01, from the NIH and the US National Heart, Lung, and Blood Institute. S. Guo, PhD, State Key Laboratory of Genetic Engineering and Ministry of Education Key Laboratory of Contemporary Anthropology, Collaborative Innovation Center for Genetics and Development, School of Life Sciences and Institutes of Biomedical Sciences, Fudan University, and Institute of Rheumatology, Immunology and Allergy, Fudan University; Y. Li, MS, State Key Laboratory of Genetic Engineering and Ministry of Education Key Laboratory of Contemporary Anthropology, Collaborative Innovation Center for Genetics and Development, School of Life Sciences and Institutes of Biomedical Sciences, Fudan University; Y. Wang, PhD, State Key Laboratory of Genetic Engineering and Ministry of Education Key Laboratory of Contemporary Anthropology, Collaborative Innovation Center for Genetics and Development, School of Life Sciences and Institutes of Biomedical Sciences, Fudan University; H. Chu, PhD, State Key Laboratory of Genetic Engineering and Ministry of Education Key Laboratory of Contemporary Anthropology, Collaborative Innovation Center for Genetics and Development, School of Life Sciences and Institutes of Biomedical Sciences, Fudan University; Y. Chen, PhD, State Key Laboratory of Genetic Engineering and Ministry of Education Key Laboratory of Contemporary Anthropology, Collaborative Innovation Center for Genetics and Development, School of Life Sciences and Institutes of Biomedical Sciences, Fudan University; Q. Liu, PhD, State Key Laboratory of Genetic Engineering and Ministry of Education Key Laboratory of Contemporary Anthropology, Collaborative Innovation Center for Genetics and Development, School of Life Sciences and Institutes of Biomedical Sciences, Fudan University; G. Guo, MD, Yiling Hospital; W. Tu, MD, Shanghai TCM-Integrated Hospital; W. Wu, MD, Institute of Rheumatology, Immunology and Allergy, Fudan University, and Division of Dermatology, Huashan Hospital, Fudan University; H. Zou, PhD, MD, Institute of Rheumatology, Immunology and Allergy, Fudan University, and Division of Rheumatology, Huashan Hospital, Fudan University; L. Yang, MD, Division of Rheumatology, Teaching Hospital of Chengdu University of TCM; R. Xiao, MD, Department of Dermatology, Second Xiangya Hospital, Central South University; Y. Ma, MS, State Key Laboratory of Genetic Engineering and Ministry of Education Key Laboratory of Contemporary Anthropology, Collaborative Innovation Center for Genetics and Development, School of Life Sciences and Institutes of Biomedical Sciences, Fudan University; F. Zhang, PhD, State Key Laboratory of Genetic Engineering and Ministry of Education Key Laboratory of Contemporary Anthropology, Collaborative Innovation Center for Genetics and Development, School of Life Sciences and Institutes of Biomedical Sciences, Fudan University; M. Xiong, PhD, School of Public Health, University of Texas; L. Jin, PhD, State Key Laboratory of Genetic Engineering and Ministry of Education Key Laboratory of Contemporary Anthropology, Collaborative Innovation Center for Genetics and Development, School of Life Sciences and Institutes of Biomedical Sciences, Fudan University; X. Zhou, MD, Medical School at Houston, University of Texas; J. Wang, PhD, State Key Laboratory of Genetic Engineering and Ministry of Education Key Laboratory of Contemporary Anthropology, Collaborative Innovation Center for Genetics and Development, School of Life Sciences and Institutes of Biomedical Sciences, Fudan University, and Institute of Rheumatology, Immunology and Allergy, Fudan University. Address correspondence to J. Wang, School of Life Sciences, Fudan University Jiangwan Campus, 2005 Songhu Road, Shanghai 200438, China. E-mail: jcwang@fudan.edu.cn. Accepted for publication January 26, 2016.
Xiaodong Zhou
From the State Key Laboratory of Genetic Engineering and Ministry of Education Key Laboratory of Contemporary Anthropology, Collaborative Innovation Center for Genetics and Development, School of Life Sciences and Institutes of Biomedical Sciences, Fudan University; Institute of Rheumatology, Immunology and Allergy, Fudan University; Shanghai Traditional Chinese Medicine (TCM)-Integrated Hospital; Division of Dermatology, and Division of Rheumatology, Huashan Hospital, Fudan University, Shanghai; Yiling Hospital, Shijiazhuang; Division of Rheumatology, Teaching Hospital of Chengdu University of TCM, Chengdu; Department of Dermatology, Second Xiangya Hospital, Central South University, Changsha, China; School of Public Health, and Medical School at Houston, University of Texas, Houston, Texas, USA. Supported by research grants from the National Basic Research Program (2012CB944604), National Science Foundation of China (81270120, 81470254), International S&T Cooperation Program of China (2013DFA30870), the 111 Project (B13016), and the US National Institutes of Health (NIH) NIAID UO1, 1U01AI09090. The computations involved in this study were supported by Fudan University High-End Computing Center. Mr. Xiong was supported by Grant 1R01AR057120–01 and 1R01HL106034-01, from the NIH and the US National Heart, Lung, and Blood Institute. S. Guo, PhD, State Key Laboratory of Genetic Engineering and Ministry of Education Key Laboratory of Contemporary Anthropology, Collaborative Innovation Center for Genetics and Development, School of Life Sciences and Institutes of Biomedical Sciences, Fudan University, and Institute of Rheumatology, Immunology and Allergy, Fudan University; Y. Li, MS, State Key Laboratory of Genetic Engineering and Ministry of Education Key Laboratory of Contemporary Anthropology, Collaborative Innovation Center for Genetics and Development, School of Life Sciences and Institutes of Biomedical Sciences, Fudan University; Y. Wang, PhD, State Key Laboratory of Genetic Engineering and Ministry of Education Key Laboratory of Contemporary Anthropology, Collaborative Innovation Center for Genetics and Development, School of Life Sciences and Institutes of Biomedical Sciences, Fudan University; H. Chu, PhD, State Key Laboratory of Genetic Engineering and Ministry of Education Key Laboratory of Contemporary Anthropology, Collaborative Innovation Center for Genetics and Development, School of Life Sciences and Institutes of Biomedical Sciences, Fudan University; Y. Chen, PhD, State Key Laboratory of Genetic Engineering and Ministry of Education Key Laboratory of Contemporary Anthropology, Collaborative Innovation Center for Genetics and Development, School of Life Sciences and Institutes of Biomedical Sciences, Fudan University; Q. Liu, PhD, State Key Laboratory of Genetic Engineering and Ministry of Education Key Laboratory of Contemporary Anthropology, Collaborative Innovation Center for Genetics and Development, School of Life Sciences and Institutes of Biomedical Sciences, Fudan University; G. Guo, MD, Yiling Hospital; W. Tu, MD, Shanghai TCM-Integrated Hospital; W. Wu, MD, Institute of Rheumatology, Immunology and Allergy, Fudan University, and Division of Dermatology, Huashan Hospital, Fudan University; H. Zou, PhD, MD, Institute of Rheumatology, Immunology and Allergy, Fudan University, and Division of Rheumatology, Huashan Hospital, Fudan University; L. Yang, MD, Division of Rheumatology, Teaching Hospital of Chengdu University of TCM; R. Xiao, MD, Department of Dermatology, Second Xiangya Hospital, Central South University; Y. Ma, MS, State Key Laboratory of Genetic Engineering and Ministry of Education Key Laboratory of Contemporary Anthropology, Collaborative Innovation Center for Genetics and Development, School of Life Sciences and Institutes of Biomedical Sciences, Fudan University; F. Zhang, PhD, State Key Laboratory of Genetic Engineering and Ministry of Education Key Laboratory of Contemporary Anthropology, Collaborative Innovation Center for Genetics and Development, School of Life Sciences and Institutes of Biomedical Sciences, Fudan University; M. Xiong, PhD, School of Public Health, University of Texas; L. Jin, PhD, State Key Laboratory of Genetic Engineering and Ministry of Education Key Laboratory of Contemporary Anthropology, Collaborative Innovation Center for Genetics and Development, School of Life Sciences and Institutes of Biomedical Sciences, Fudan University; X. Zhou, MD, Medical School at Houston, University of Texas; J. Wang, PhD, State Key Laboratory of Genetic Engineering and Ministry of Education Key Laboratory of Contemporary Anthropology, Collaborative Innovation Center for Genetics and Development, School of Life Sciences and Institutes of Biomedical Sciences, Fudan University, and Institute of Rheumatology, Immunology and Allergy, Fudan University. Address correspondence to J. Wang, School of Life Sciences, Fudan University Jiangwan Campus, 2005 Songhu Road, Shanghai 200438, China. E-mail: jcwang@fudan.edu.cn. Accepted for publication January 26, 2016.
Jiucun Wang
From the State Key Laboratory of Genetic Engineering and Ministry of Education Key Laboratory of Contemporary Anthropology, Collaborative Innovation Center for Genetics and Development, School of Life Sciences and Institutes of Biomedical Sciences, Fudan University; Institute of Rheumatology, Immunology and Allergy, Fudan University; Shanghai Traditional Chinese Medicine (TCM)-Integrated Hospital; Division of Dermatology, and Division of Rheumatology, Huashan Hospital, Fudan University, Shanghai; Yiling Hospital, Shijiazhuang; Division of Rheumatology, Teaching Hospital of Chengdu University of TCM, Chengdu; Department of Dermatology, Second Xiangya Hospital, Central South University, Changsha, China; School of Public Health, and Medical School at Houston, University of Texas, Houston, Texas, USA. Supported by research grants from the National Basic Research Program (2012CB944604), National Science Foundation of China (81270120, 81470254), International S&T Cooperation Program of China (2013DFA30870), the 111 Project (B13016), and the US National Institutes of Health (NIH) NIAID UO1, 1U01AI09090. The computations involved in this study were supported by Fudan University High-End Computing Center. Mr. Xiong was supported by Grant 1R01AR057120–01 and 1R01HL106034-01, from the NIH and the US National Heart, Lung, and Blood Institute. S. Guo, PhD, State Key Laboratory of Genetic Engineering and Ministry of Education Key Laboratory of Contemporary Anthropology, Collaborative Innovation Center for Genetics and Development, School of Life Sciences and Institutes of Biomedical Sciences, Fudan University, and Institute of Rheumatology, Immunology and Allergy, Fudan University; Y. Li, MS, State Key Laboratory of Genetic Engineering and Ministry of Education Key Laboratory of Contemporary Anthropology, Collaborative Innovation Center for Genetics and Development, School of Life Sciences and Institutes of Biomedical Sciences, Fudan University; Y. Wang, PhD, State Key Laboratory of Genetic Engineering and Ministry of Education Key Laboratory of Contemporary Anthropology, Collaborative Innovation Center for Genetics and Development, School of Life Sciences and Institutes of Biomedical Sciences, Fudan University; H. Chu, PhD, State Key Laboratory of Genetic Engineering and Ministry of Education Key Laboratory of Contemporary Anthropology, Collaborative Innovation Center for Genetics and Development, School of Life Sciences and Institutes of Biomedical Sciences, Fudan University; Y. Chen, PhD, State Key Laboratory of Genetic Engineering and Ministry of Education Key Laboratory of Contemporary Anthropology, Collaborative Innovation Center for Genetics and Development, School of Life Sciences and Institutes of Biomedical Sciences, Fudan University; Q. Liu, PhD, State Key Laboratory of Genetic Engineering and Ministry of Education Key Laboratory of Contemporary Anthropology, Collaborative Innovation Center for Genetics and Development, School of Life Sciences and Institutes of Biomedical Sciences, Fudan University; G. Guo, MD, Yiling Hospital; W. Tu, MD, Shanghai TCM-Integrated Hospital; W. Wu, MD, Institute of Rheumatology, Immunology and Allergy, Fudan University, and Division of Dermatology, Huashan Hospital, Fudan University; H. Zou, PhD, MD, Institute of Rheumatology, Immunology and Allergy, Fudan University, and Division of Rheumatology, Huashan Hospital, Fudan University; L. Yang, MD, Division of Rheumatology, Teaching Hospital of Chengdu University of TCM; R. Xiao, MD, Department of Dermatology, Second Xiangya Hospital, Central South University; Y. Ma, MS, State Key Laboratory of Genetic Engineering and Ministry of Education Key Laboratory of Contemporary Anthropology, Collaborative Innovation Center for Genetics and Development, School of Life Sciences and Institutes of Biomedical Sciences, Fudan University; F. Zhang, PhD, State Key Laboratory of Genetic Engineering and Ministry of Education Key Laboratory of Contemporary Anthropology, Collaborative Innovation Center for Genetics and Development, School of Life Sciences and Institutes of Biomedical Sciences, Fudan University; M. Xiong, PhD, School of Public Health, University of Texas; L. Jin, PhD, State Key Laboratory of Genetic Engineering and Ministry of Education Key Laboratory of Contemporary Anthropology, Collaborative Innovation Center for Genetics and Development, School of Life Sciences and Institutes of Biomedical Sciences, Fudan University; X. Zhou, MD, Medical School at Houston, University of Texas; J. Wang, PhD, State Key Laboratory of Genetic Engineering and Ministry of Education Key Laboratory of Contemporary Anthropology, Collaborative Innovation Center for Genetics and Development, School of Life Sciences and Institutes of Biomedical Sciences, Fudan University, and Institute of Rheumatology, Immunology and Allergy, Fudan University. Address correspondence to J. Wang, School of Life Sciences, Fudan University Jiangwan Campus, 2005 Songhu Road, Shanghai 200438, China. E-mail: jcwang@fudan.edu.cn. Accepted for publication January 26, 2016.
In this issue
The Journal of Rheumatology
Vol. 51, Issue 3
1 Mar 2024
Copy Number Variation of HLA-DQA1 and APOBEC3A/3B Contribute to the Susceptibility of Systemic Sclerosis in the Chinese Han Population
Shicheng Guo, Yuan Li, Yi Wang, Haiyan Chu, Yulin Chen, Qingmei Liu, Gang Guo, Wenzhen Tu, Wenyu Wu, Hejian Zou, Li Yang, Rong Xiao, Yanyun Ma, Feng Zhang, Momiao Xiong, Li Jin, Xiaodong Zhou, Jiucun Wang
The Journal of Rheumatology Apr 2016, jrheum.150945; DOI: 10.3899/jrheum.150945
Copy Number Variation of HLA-DQA1 and APOBEC3A/3B Contribute to the Susceptibility of Systemic Sclerosis in the Chinese Han Population
Shicheng Guo, Yuan Li, Yi Wang, Haiyan Chu, Yulin Chen, Qingmei Liu, Gang Guo, Wenzhen Tu, Wenyu Wu, Hejian Zou, Li Yang, Rong Xiao, Yanyun Ma, Feng Zhang, Momiao Xiong, Li Jin, Xiaodong Zhou, Jiucun Wang
The Journal of Rheumatology Apr 2016, jrheum.150945; DOI: 10.3899/jrheum.150945