Research ArticleArticle
The Longterm Effect of Early Intensive Treatment of Seniors with Rheumatoid Arthritis: A Comparison of 2 Population-based Cohort Studies on Time to Joint Replacement Surgery
Jessica Widdifield, Cristiano S. Moura, Yishu Wang, Michal Abrahamowicz, J. Michael Paterson, Anjie Huang, Marie-Eve Beauchamp, Gilles Boire, Paul R. Fortin, Louis Bessette, Claire Bombardier, John G. Hanly, Debbie Feldman, Sasha Bernatsky and the CAnadian Network for Advanced Interdisciplinary Methods for comparative effectiveness research (CAN-AIM)
The Journal of Rheumatology February 2016, jrheum.151156; DOI: https://doi.org/10.3899/jrheum.151156
Jessica Widdifield
From the Department of Epidemiology, Biostatistics and Occupational Health, McGill University; Division of Clinical Epidemiology, Research Institute of the McGill University Health Centre; École de Réadaptation, Université de Montréal, Montreal; Department of Medicine, Université de Sherbrooke, Sherbrooke; Division of Rheumatology, Department of Medicine, Centre de recherche du CHU de Québec, Université Laval, Quebec City, Quebec; Institute for Clinical Evaluative Sciences, University of Toronto; Institute of Health Policy, Management and Evaluation; Division of Rheumatology, University of Toronto, Toronto; Department of Family Medicine, McMaster University, Hamilton, Ontario; Division of Rheumatology, Departments of Medicine and Pathology, Dalhousie University, Halifax, Nova Scotia, Canada. Supported by The CAnadian Network for Advanced Interdisciplinary Methods for comparative effectiveness research (CAN-AIM) group (www.canaim.ca), which is funded by the Canadian Institutes of Health Research (CIHR), through the Drug Safety and Effectiveness Network; this study was supported by the Institute for Clinical Evaluative Sciences (ICES), a non-profit research corporation funded by the Ontario Ministry of Health and Long-Term Care (MOHLTC). The opinions, results, and conclusions are those of the authors and are independent from the funding sources. No endorsement by ICES or the Ontario MOHLTC is intended or should be inferred. Parts of this material are based on data and information compiled and provided by the Canadian Institute for Health Information (CIHI). However, the analyses, conclusions, opinions, and statements expressed herein are those of the authors, and not necessarily those of CIHI. JW holds fellowship awards from The Arthritis Society and CIHR Banting. J. Widdifield, PhD, Department of Epidemiology, Biostatistics and Occupational Health, McGill University, and Division of Clinical Epidemiology, Research Institute of the McGill University Health Centre, and Institute for Clinical Evaluative Sciences; C.S. Moura, PhD, Department of Epidemiology, Biostatistics and Occupational Health, McGill University, and Division of Clinical Epidemiology, Research Institute of the McGill University Health Centre; Y. Wang, PhD(c), Department of Epidemiology, Biostatistics and Occupational Health, McGill University; M. Abrahamowicz, PhD, Department of Epidemiology, Biostatistics and Occupational Health, McGill University; J.M. Paterson, MSc, Institute for Clinical Evaluative Sciences, and University of Toronto, Institute of Health Policy, Management and Evaluation, and Department of Family Medicine, McMaster University; A. Huang, MSc, Institute for Clinical Evaluative Sciences; M.E. Beauchamp, PhD, Division of Clinical Epidemiology, Research Institute of the McGill University Health Centre; G. Boire, MD, FRCPC, MSc, Department of Medicine, Université de Sherbrooke; P.R. Fortin, MD, FRCPC, MPH, Division of Rheumatology, Department of Medicine, Centre de recherche du CHU de Québec, Université Laval; L. Bessette, MD, FRCPC, MSc, Division of Rheumatology, Department of Medicine, Centre de recherche du CHU de Québec, Université Laval; C. Bombardier, MD, FRCPC, Division of Rheumatology, University of Toronto; J.G. Hanly, MD, FRCPC, Division of Rheumatology, Departments of Medicine and Pathology, Dalhousie University; D. Feldman, PT, PhD, École de Réadaptation, Université de Montréal; S. Bernatsky, MD, FRCPC, PhD, Department of Epidemiology, Biostatistics and Occupational Health, McGill University, and Division of Clinical Epidemiology, Research Institute of the McGill University Health Centre. Address correspondence to Dr. Jessica Widdifield, Division of Clinical Epidemiology, Research Institute of the McGill University Health Centre, 687 Pine Avenue West, V Building, Montreal, Quebec, Canada, H3A 1A1. E-mail: Jessica.widdifield@alum.utoronto.ca. Accepted for publication January 8, 2016.
Cristiano S. Moura
From the Department of Epidemiology, Biostatistics and Occupational Health, McGill University; Division of Clinical Epidemiology, Research Institute of the McGill University Health Centre; École de Réadaptation, Université de Montréal, Montreal; Department of Medicine, Université de Sherbrooke, Sherbrooke; Division of Rheumatology, Department of Medicine, Centre de recherche du CHU de Québec, Université Laval, Quebec City, Quebec; Institute for Clinical Evaluative Sciences, University of Toronto; Institute of Health Policy, Management and Evaluation; Division of Rheumatology, University of Toronto, Toronto; Department of Family Medicine, McMaster University, Hamilton, Ontario; Division of Rheumatology, Departments of Medicine and Pathology, Dalhousie University, Halifax, Nova Scotia, Canada. Supported by The CAnadian Network for Advanced Interdisciplinary Methods for comparative effectiveness research (CAN-AIM) group (www.canaim.ca), which is funded by the Canadian Institutes of Health Research (CIHR), through the Drug Safety and Effectiveness Network; this study was supported by the Institute for Clinical Evaluative Sciences (ICES), a non-profit research corporation funded by the Ontario Ministry of Health and Long-Term Care (MOHLTC). The opinions, results, and conclusions are those of the authors and are independent from the funding sources. No endorsement by ICES or the Ontario MOHLTC is intended or should be inferred. Parts of this material are based on data and information compiled and provided by the Canadian Institute for Health Information (CIHI). However, the analyses, conclusions, opinions, and statements expressed herein are those of the authors, and not necessarily those of CIHI. JW holds fellowship awards from The Arthritis Society and CIHR Banting. J. Widdifield, PhD, Department of Epidemiology, Biostatistics and Occupational Health, McGill University, and Division of Clinical Epidemiology, Research Institute of the McGill University Health Centre, and Institute for Clinical Evaluative Sciences; C.S. Moura, PhD, Department of Epidemiology, Biostatistics and Occupational Health, McGill University, and Division of Clinical Epidemiology, Research Institute of the McGill University Health Centre; Y. Wang, PhD(c), Department of Epidemiology, Biostatistics and Occupational Health, McGill University; M. Abrahamowicz, PhD, Department of Epidemiology, Biostatistics and Occupational Health, McGill University; J.M. Paterson, MSc, Institute for Clinical Evaluative Sciences, and University of Toronto, Institute of Health Policy, Management and Evaluation, and Department of Family Medicine, McMaster University; A. Huang, MSc, Institute for Clinical Evaluative Sciences; M.E. Beauchamp, PhD, Division of Clinical Epidemiology, Research Institute of the McGill University Health Centre; G. Boire, MD, FRCPC, MSc, Department of Medicine, Université de Sherbrooke; P.R. Fortin, MD, FRCPC, MPH, Division of Rheumatology, Department of Medicine, Centre de recherche du CHU de Québec, Université Laval; L. Bessette, MD, FRCPC, MSc, Division of Rheumatology, Department of Medicine, Centre de recherche du CHU de Québec, Université Laval; C. Bombardier, MD, FRCPC, Division of Rheumatology, University of Toronto; J.G. Hanly, MD, FRCPC, Division of Rheumatology, Departments of Medicine and Pathology, Dalhousie University; D. Feldman, PT, PhD, École de Réadaptation, Université de Montréal; S. Bernatsky, MD, FRCPC, PhD, Department of Epidemiology, Biostatistics and Occupational Health, McGill University, and Division of Clinical Epidemiology, Research Institute of the McGill University Health Centre. Address correspondence to Dr. Jessica Widdifield, Division of Clinical Epidemiology, Research Institute of the McGill University Health Centre, 687 Pine Avenue West, V Building, Montreal, Quebec, Canada, H3A 1A1. E-mail: Jessica.widdifield@alum.utoronto.ca. Accepted for publication January 8, 2016.
Yishu Wang
From the Department of Epidemiology, Biostatistics and Occupational Health, McGill University; Division of Clinical Epidemiology, Research Institute of the McGill University Health Centre; École de Réadaptation, Université de Montréal, Montreal; Department of Medicine, Université de Sherbrooke, Sherbrooke; Division of Rheumatology, Department of Medicine, Centre de recherche du CHU de Québec, Université Laval, Quebec City, Quebec; Institute for Clinical Evaluative Sciences, University of Toronto; Institute of Health Policy, Management and Evaluation; Division of Rheumatology, University of Toronto, Toronto; Department of Family Medicine, McMaster University, Hamilton, Ontario; Division of Rheumatology, Departments of Medicine and Pathology, Dalhousie University, Halifax, Nova Scotia, Canada. Supported by The CAnadian Network for Advanced Interdisciplinary Methods for comparative effectiveness research (CAN-AIM) group (www.canaim.ca), which is funded by the Canadian Institutes of Health Research (CIHR), through the Drug Safety and Effectiveness Network; this study was supported by the Institute for Clinical Evaluative Sciences (ICES), a non-profit research corporation funded by the Ontario Ministry of Health and Long-Term Care (MOHLTC). The opinions, results, and conclusions are those of the authors and are independent from the funding sources. No endorsement by ICES or the Ontario MOHLTC is intended or should be inferred. Parts of this material are based on data and information compiled and provided by the Canadian Institute for Health Information (CIHI). However, the analyses, conclusions, opinions, and statements expressed herein are those of the authors, and not necessarily those of CIHI. JW holds fellowship awards from The Arthritis Society and CIHR Banting. J. Widdifield, PhD, Department of Epidemiology, Biostatistics and Occupational Health, McGill University, and Division of Clinical Epidemiology, Research Institute of the McGill University Health Centre, and Institute for Clinical Evaluative Sciences; C.S. Moura, PhD, Department of Epidemiology, Biostatistics and Occupational Health, McGill University, and Division of Clinical Epidemiology, Research Institute of the McGill University Health Centre; Y. Wang, PhD(c), Department of Epidemiology, Biostatistics and Occupational Health, McGill University; M. Abrahamowicz, PhD, Department of Epidemiology, Biostatistics and Occupational Health, McGill University; J.M. Paterson, MSc, Institute for Clinical Evaluative Sciences, and University of Toronto, Institute of Health Policy, Management and Evaluation, and Department of Family Medicine, McMaster University; A. Huang, MSc, Institute for Clinical Evaluative Sciences; M.E. Beauchamp, PhD, Division of Clinical Epidemiology, Research Institute of the McGill University Health Centre; G. Boire, MD, FRCPC, MSc, Department of Medicine, Université de Sherbrooke; P.R. Fortin, MD, FRCPC, MPH, Division of Rheumatology, Department of Medicine, Centre de recherche du CHU de Québec, Université Laval; L. Bessette, MD, FRCPC, MSc, Division of Rheumatology, Department of Medicine, Centre de recherche du CHU de Québec, Université Laval; C. Bombardier, MD, FRCPC, Division of Rheumatology, University of Toronto; J.G. Hanly, MD, FRCPC, Division of Rheumatology, Departments of Medicine and Pathology, Dalhousie University; D. Feldman, PT, PhD, École de Réadaptation, Université de Montréal; S. Bernatsky, MD, FRCPC, PhD, Department of Epidemiology, Biostatistics and Occupational Health, McGill University, and Division of Clinical Epidemiology, Research Institute of the McGill University Health Centre. Address correspondence to Dr. Jessica Widdifield, Division of Clinical Epidemiology, Research Institute of the McGill University Health Centre, 687 Pine Avenue West, V Building, Montreal, Quebec, Canada, H3A 1A1. E-mail: Jessica.widdifield@alum.utoronto.ca. Accepted for publication January 8, 2016.
Michal Abrahamowicz
From the Department of Epidemiology, Biostatistics and Occupational Health, McGill University; Division of Clinical Epidemiology, Research Institute of the McGill University Health Centre; École de Réadaptation, Université de Montréal, Montreal; Department of Medicine, Université de Sherbrooke, Sherbrooke; Division of Rheumatology, Department of Medicine, Centre de recherche du CHU de Québec, Université Laval, Quebec City, Quebec; Institute for Clinical Evaluative Sciences, University of Toronto; Institute of Health Policy, Management and Evaluation; Division of Rheumatology, University of Toronto, Toronto; Department of Family Medicine, McMaster University, Hamilton, Ontario; Division of Rheumatology, Departments of Medicine and Pathology, Dalhousie University, Halifax, Nova Scotia, Canada. Supported by The CAnadian Network for Advanced Interdisciplinary Methods for comparative effectiveness research (CAN-AIM) group (www.canaim.ca), which is funded by the Canadian Institutes of Health Research (CIHR), through the Drug Safety and Effectiveness Network; this study was supported by the Institute for Clinical Evaluative Sciences (ICES), a non-profit research corporation funded by the Ontario Ministry of Health and Long-Term Care (MOHLTC). The opinions, results, and conclusions are those of the authors and are independent from the funding sources. No endorsement by ICES or the Ontario MOHLTC is intended or should be inferred. Parts of this material are based on data and information compiled and provided by the Canadian Institute for Health Information (CIHI). However, the analyses, conclusions, opinions, and statements expressed herein are those of the authors, and not necessarily those of CIHI. JW holds fellowship awards from The Arthritis Society and CIHR Banting. J. Widdifield, PhD, Department of Epidemiology, Biostatistics and Occupational Health, McGill University, and Division of Clinical Epidemiology, Research Institute of the McGill University Health Centre, and Institute for Clinical Evaluative Sciences; C.S. Moura, PhD, Department of Epidemiology, Biostatistics and Occupational Health, McGill University, and Division of Clinical Epidemiology, Research Institute of the McGill University Health Centre; Y. Wang, PhD(c), Department of Epidemiology, Biostatistics and Occupational Health, McGill University; M. Abrahamowicz, PhD, Department of Epidemiology, Biostatistics and Occupational Health, McGill University; J.M. Paterson, MSc, Institute for Clinical Evaluative Sciences, and University of Toronto, Institute of Health Policy, Management and Evaluation, and Department of Family Medicine, McMaster University; A. Huang, MSc, Institute for Clinical Evaluative Sciences; M.E. Beauchamp, PhD, Division of Clinical Epidemiology, Research Institute of the McGill University Health Centre; G. Boire, MD, FRCPC, MSc, Department of Medicine, Université de Sherbrooke; P.R. Fortin, MD, FRCPC, MPH, Division of Rheumatology, Department of Medicine, Centre de recherche du CHU de Québec, Université Laval; L. Bessette, MD, FRCPC, MSc, Division of Rheumatology, Department of Medicine, Centre de recherche du CHU de Québec, Université Laval; C. Bombardier, MD, FRCPC, Division of Rheumatology, University of Toronto; J.G. Hanly, MD, FRCPC, Division of Rheumatology, Departments of Medicine and Pathology, Dalhousie University; D. Feldman, PT, PhD, École de Réadaptation, Université de Montréal; S. Bernatsky, MD, FRCPC, PhD, Department of Epidemiology, Biostatistics and Occupational Health, McGill University, and Division of Clinical Epidemiology, Research Institute of the McGill University Health Centre. Address correspondence to Dr. Jessica Widdifield, Division of Clinical Epidemiology, Research Institute of the McGill University Health Centre, 687 Pine Avenue West, V Building, Montreal, Quebec, Canada, H3A 1A1. E-mail: Jessica.widdifield@alum.utoronto.ca. Accepted for publication January 8, 2016.
J. Michael Paterson
From the Department of Epidemiology, Biostatistics and Occupational Health, McGill University; Division of Clinical Epidemiology, Research Institute of the McGill University Health Centre; École de Réadaptation, Université de Montréal, Montreal; Department of Medicine, Université de Sherbrooke, Sherbrooke; Division of Rheumatology, Department of Medicine, Centre de recherche du CHU de Québec, Université Laval, Quebec City, Quebec; Institute for Clinical Evaluative Sciences, University of Toronto; Institute of Health Policy, Management and Evaluation; Division of Rheumatology, University of Toronto, Toronto; Department of Family Medicine, McMaster University, Hamilton, Ontario; Division of Rheumatology, Departments of Medicine and Pathology, Dalhousie University, Halifax, Nova Scotia, Canada. Supported by The CAnadian Network for Advanced Interdisciplinary Methods for comparative effectiveness research (CAN-AIM) group (www.canaim.ca), which is funded by the Canadian Institutes of Health Research (CIHR), through the Drug Safety and Effectiveness Network; this study was supported by the Institute for Clinical Evaluative Sciences (ICES), a non-profit research corporation funded by the Ontario Ministry of Health and Long-Term Care (MOHLTC). The opinions, results, and conclusions are those of the authors and are independent from the funding sources. No endorsement by ICES or the Ontario MOHLTC is intended or should be inferred. Parts of this material are based on data and information compiled and provided by the Canadian Institute for Health Information (CIHI). However, the analyses, conclusions, opinions, and statements expressed herein are those of the authors, and not necessarily those of CIHI. JW holds fellowship awards from The Arthritis Society and CIHR Banting. J. Widdifield, PhD, Department of Epidemiology, Biostatistics and Occupational Health, McGill University, and Division of Clinical Epidemiology, Research Institute of the McGill University Health Centre, and Institute for Clinical Evaluative Sciences; C.S. Moura, PhD, Department of Epidemiology, Biostatistics and Occupational Health, McGill University, and Division of Clinical Epidemiology, Research Institute of the McGill University Health Centre; Y. Wang, PhD(c), Department of Epidemiology, Biostatistics and Occupational Health, McGill University; M. Abrahamowicz, PhD, Department of Epidemiology, Biostatistics and Occupational Health, McGill University; J.M. Paterson, MSc, Institute for Clinical Evaluative Sciences, and University of Toronto, Institute of Health Policy, Management and Evaluation, and Department of Family Medicine, McMaster University; A. Huang, MSc, Institute for Clinical Evaluative Sciences; M.E. Beauchamp, PhD, Division of Clinical Epidemiology, Research Institute of the McGill University Health Centre; G. Boire, MD, FRCPC, MSc, Department of Medicine, Université de Sherbrooke; P.R. Fortin, MD, FRCPC, MPH, Division of Rheumatology, Department of Medicine, Centre de recherche du CHU de Québec, Université Laval; L. Bessette, MD, FRCPC, MSc, Division of Rheumatology, Department of Medicine, Centre de recherche du CHU de Québec, Université Laval; C. Bombardier, MD, FRCPC, Division of Rheumatology, University of Toronto; J.G. Hanly, MD, FRCPC, Division of Rheumatology, Departments of Medicine and Pathology, Dalhousie University; D. Feldman, PT, PhD, École de Réadaptation, Université de Montréal; S. Bernatsky, MD, FRCPC, PhD, Department of Epidemiology, Biostatistics and Occupational Health, McGill University, and Division of Clinical Epidemiology, Research Institute of the McGill University Health Centre. Address correspondence to Dr. Jessica Widdifield, Division of Clinical Epidemiology, Research Institute of the McGill University Health Centre, 687 Pine Avenue West, V Building, Montreal, Quebec, Canada, H3A 1A1. E-mail: Jessica.widdifield@alum.utoronto.ca. Accepted for publication January 8, 2016.
Anjie Huang
From the Department of Epidemiology, Biostatistics and Occupational Health, McGill University; Division of Clinical Epidemiology, Research Institute of the McGill University Health Centre; École de Réadaptation, Université de Montréal, Montreal; Department of Medicine, Université de Sherbrooke, Sherbrooke; Division of Rheumatology, Department of Medicine, Centre de recherche du CHU de Québec, Université Laval, Quebec City, Quebec; Institute for Clinical Evaluative Sciences, University of Toronto; Institute of Health Policy, Management and Evaluation; Division of Rheumatology, University of Toronto, Toronto; Department of Family Medicine, McMaster University, Hamilton, Ontario; Division of Rheumatology, Departments of Medicine and Pathology, Dalhousie University, Halifax, Nova Scotia, Canada. Supported by The CAnadian Network for Advanced Interdisciplinary Methods for comparative effectiveness research (CAN-AIM) group (www.canaim.ca), which is funded by the Canadian Institutes of Health Research (CIHR), through the Drug Safety and Effectiveness Network; this study was supported by the Institute for Clinical Evaluative Sciences (ICES), a non-profit research corporation funded by the Ontario Ministry of Health and Long-Term Care (MOHLTC). The opinions, results, and conclusions are those of the authors and are independent from the funding sources. No endorsement by ICES or the Ontario MOHLTC is intended or should be inferred. Parts of this material are based on data and information compiled and provided by the Canadian Institute for Health Information (CIHI). However, the analyses, conclusions, opinions, and statements expressed herein are those of the authors, and not necessarily those of CIHI. JW holds fellowship awards from The Arthritis Society and CIHR Banting. J. Widdifield, PhD, Department of Epidemiology, Biostatistics and Occupational Health, McGill University, and Division of Clinical Epidemiology, Research Institute of the McGill University Health Centre, and Institute for Clinical Evaluative Sciences; C.S. Moura, PhD, Department of Epidemiology, Biostatistics and Occupational Health, McGill University, and Division of Clinical Epidemiology, Research Institute of the McGill University Health Centre; Y. Wang, PhD(c), Department of Epidemiology, Biostatistics and Occupational Health, McGill University; M. Abrahamowicz, PhD, Department of Epidemiology, Biostatistics and Occupational Health, McGill University; J.M. Paterson, MSc, Institute for Clinical Evaluative Sciences, and University of Toronto, Institute of Health Policy, Management and Evaluation, and Department of Family Medicine, McMaster University; A. Huang, MSc, Institute for Clinical Evaluative Sciences; M.E. Beauchamp, PhD, Division of Clinical Epidemiology, Research Institute of the McGill University Health Centre; G. Boire, MD, FRCPC, MSc, Department of Medicine, Université de Sherbrooke; P.R. Fortin, MD, FRCPC, MPH, Division of Rheumatology, Department of Medicine, Centre de recherche du CHU de Québec, Université Laval; L. Bessette, MD, FRCPC, MSc, Division of Rheumatology, Department of Medicine, Centre de recherche du CHU de Québec, Université Laval; C. Bombardier, MD, FRCPC, Division of Rheumatology, University of Toronto; J.G. Hanly, MD, FRCPC, Division of Rheumatology, Departments of Medicine and Pathology, Dalhousie University; D. Feldman, PT, PhD, École de Réadaptation, Université de Montréal; S. Bernatsky, MD, FRCPC, PhD, Department of Epidemiology, Biostatistics and Occupational Health, McGill University, and Division of Clinical Epidemiology, Research Institute of the McGill University Health Centre. Address correspondence to Dr. Jessica Widdifield, Division of Clinical Epidemiology, Research Institute of the McGill University Health Centre, 687 Pine Avenue West, V Building, Montreal, Quebec, Canada, H3A 1A1. E-mail: Jessica.widdifield@alum.utoronto.ca. Accepted for publication January 8, 2016.
Marie-Eve Beauchamp
From the Department of Epidemiology, Biostatistics and Occupational Health, McGill University; Division of Clinical Epidemiology, Research Institute of the McGill University Health Centre; École de Réadaptation, Université de Montréal, Montreal; Department of Medicine, Université de Sherbrooke, Sherbrooke; Division of Rheumatology, Department of Medicine, Centre de recherche du CHU de Québec, Université Laval, Quebec City, Quebec; Institute for Clinical Evaluative Sciences, University of Toronto; Institute of Health Policy, Management and Evaluation; Division of Rheumatology, University of Toronto, Toronto; Department of Family Medicine, McMaster University, Hamilton, Ontario; Division of Rheumatology, Departments of Medicine and Pathology, Dalhousie University, Halifax, Nova Scotia, Canada. Supported by The CAnadian Network for Advanced Interdisciplinary Methods for comparative effectiveness research (CAN-AIM) group (www.canaim.ca), which is funded by the Canadian Institutes of Health Research (CIHR), through the Drug Safety and Effectiveness Network; this study was supported by the Institute for Clinical Evaluative Sciences (ICES), a non-profit research corporation funded by the Ontario Ministry of Health and Long-Term Care (MOHLTC). The opinions, results, and conclusions are those of the authors and are independent from the funding sources. No endorsement by ICES or the Ontario MOHLTC is intended or should be inferred. Parts of this material are based on data and information compiled and provided by the Canadian Institute for Health Information (CIHI). However, the analyses, conclusions, opinions, and statements expressed herein are those of the authors, and not necessarily those of CIHI. JW holds fellowship awards from The Arthritis Society and CIHR Banting. J. Widdifield, PhD, Department of Epidemiology, Biostatistics and Occupational Health, McGill University, and Division of Clinical Epidemiology, Research Institute of the McGill University Health Centre, and Institute for Clinical Evaluative Sciences; C.S. Moura, PhD, Department of Epidemiology, Biostatistics and Occupational Health, McGill University, and Division of Clinical Epidemiology, Research Institute of the McGill University Health Centre; Y. Wang, PhD(c), Department of Epidemiology, Biostatistics and Occupational Health, McGill University; M. Abrahamowicz, PhD, Department of Epidemiology, Biostatistics and Occupational Health, McGill University; J.M. Paterson, MSc, Institute for Clinical Evaluative Sciences, and University of Toronto, Institute of Health Policy, Management and Evaluation, and Department of Family Medicine, McMaster University; A. Huang, MSc, Institute for Clinical Evaluative Sciences; M.E. Beauchamp, PhD, Division of Clinical Epidemiology, Research Institute of the McGill University Health Centre; G. Boire, MD, FRCPC, MSc, Department of Medicine, Université de Sherbrooke; P.R. Fortin, MD, FRCPC, MPH, Division of Rheumatology, Department of Medicine, Centre de recherche du CHU de Québec, Université Laval; L. Bessette, MD, FRCPC, MSc, Division of Rheumatology, Department of Medicine, Centre de recherche du CHU de Québec, Université Laval; C. Bombardier, MD, FRCPC, Division of Rheumatology, University of Toronto; J.G. Hanly, MD, FRCPC, Division of Rheumatology, Departments of Medicine and Pathology, Dalhousie University; D. Feldman, PT, PhD, École de Réadaptation, Université de Montréal; S. Bernatsky, MD, FRCPC, PhD, Department of Epidemiology, Biostatistics and Occupational Health, McGill University, and Division of Clinical Epidemiology, Research Institute of the McGill University Health Centre. Address correspondence to Dr. Jessica Widdifield, Division of Clinical Epidemiology, Research Institute of the McGill University Health Centre, 687 Pine Avenue West, V Building, Montreal, Quebec, Canada, H3A 1A1. E-mail: Jessica.widdifield@alum.utoronto.ca. Accepted for publication January 8, 2016.
Gilles Boire
From the Department of Epidemiology, Biostatistics and Occupational Health, McGill University; Division of Clinical Epidemiology, Research Institute of the McGill University Health Centre; École de Réadaptation, Université de Montréal, Montreal; Department of Medicine, Université de Sherbrooke, Sherbrooke; Division of Rheumatology, Department of Medicine, Centre de recherche du CHU de Québec, Université Laval, Quebec City, Quebec; Institute for Clinical Evaluative Sciences, University of Toronto; Institute of Health Policy, Management and Evaluation; Division of Rheumatology, University of Toronto, Toronto; Department of Family Medicine, McMaster University, Hamilton, Ontario; Division of Rheumatology, Departments of Medicine and Pathology, Dalhousie University, Halifax, Nova Scotia, Canada. Supported by The CAnadian Network for Advanced Interdisciplinary Methods for comparative effectiveness research (CAN-AIM) group (www.canaim.ca), which is funded by the Canadian Institutes of Health Research (CIHR), through the Drug Safety and Effectiveness Network; this study was supported by the Institute for Clinical Evaluative Sciences (ICES), a non-profit research corporation funded by the Ontario Ministry of Health and Long-Term Care (MOHLTC). The opinions, results, and conclusions are those of the authors and are independent from the funding sources. No endorsement by ICES or the Ontario MOHLTC is intended or should be inferred. Parts of this material are based on data and information compiled and provided by the Canadian Institute for Health Information (CIHI). However, the analyses, conclusions, opinions, and statements expressed herein are those of the authors, and not necessarily those of CIHI. JW holds fellowship awards from The Arthritis Society and CIHR Banting. J. Widdifield, PhD, Department of Epidemiology, Biostatistics and Occupational Health, McGill University, and Division of Clinical Epidemiology, Research Institute of the McGill University Health Centre, and Institute for Clinical Evaluative Sciences; C.S. Moura, PhD, Department of Epidemiology, Biostatistics and Occupational Health, McGill University, and Division of Clinical Epidemiology, Research Institute of the McGill University Health Centre; Y. Wang, PhD(c), Department of Epidemiology, Biostatistics and Occupational Health, McGill University; M. Abrahamowicz, PhD, Department of Epidemiology, Biostatistics and Occupational Health, McGill University; J.M. Paterson, MSc, Institute for Clinical Evaluative Sciences, and University of Toronto, Institute of Health Policy, Management and Evaluation, and Department of Family Medicine, McMaster University; A. Huang, MSc, Institute for Clinical Evaluative Sciences; M.E. Beauchamp, PhD, Division of Clinical Epidemiology, Research Institute of the McGill University Health Centre; G. Boire, MD, FRCPC, MSc, Department of Medicine, Université de Sherbrooke; P.R. Fortin, MD, FRCPC, MPH, Division of Rheumatology, Department of Medicine, Centre de recherche du CHU de Québec, Université Laval; L. Bessette, MD, FRCPC, MSc, Division of Rheumatology, Department of Medicine, Centre de recherche du CHU de Québec, Université Laval; C. Bombardier, MD, FRCPC, Division of Rheumatology, University of Toronto; J.G. Hanly, MD, FRCPC, Division of Rheumatology, Departments of Medicine and Pathology, Dalhousie University; D. Feldman, PT, PhD, École de Réadaptation, Université de Montréal; S. Bernatsky, MD, FRCPC, PhD, Department of Epidemiology, Biostatistics and Occupational Health, McGill University, and Division of Clinical Epidemiology, Research Institute of the McGill University Health Centre. Address correspondence to Dr. Jessica Widdifield, Division of Clinical Epidemiology, Research Institute of the McGill University Health Centre, 687 Pine Avenue West, V Building, Montreal, Quebec, Canada, H3A 1A1. E-mail: Jessica.widdifield@alum.utoronto.ca. Accepted for publication January 8, 2016.
Paul R. Fortin
From the Department of Epidemiology, Biostatistics and Occupational Health, McGill University; Division of Clinical Epidemiology, Research Institute of the McGill University Health Centre; École de Réadaptation, Université de Montréal, Montreal; Department of Medicine, Université de Sherbrooke, Sherbrooke; Division of Rheumatology, Department of Medicine, Centre de recherche du CHU de Québec, Université Laval, Quebec City, Quebec; Institute for Clinical Evaluative Sciences, University of Toronto; Institute of Health Policy, Management and Evaluation; Division of Rheumatology, University of Toronto, Toronto; Department of Family Medicine, McMaster University, Hamilton, Ontario; Division of Rheumatology, Departments of Medicine and Pathology, Dalhousie University, Halifax, Nova Scotia, Canada. Supported by The CAnadian Network for Advanced Interdisciplinary Methods for comparative effectiveness research (CAN-AIM) group (www.canaim.ca), which is funded by the Canadian Institutes of Health Research (CIHR), through the Drug Safety and Effectiveness Network; this study was supported by the Institute for Clinical Evaluative Sciences (ICES), a non-profit research corporation funded by the Ontario Ministry of Health and Long-Term Care (MOHLTC). The opinions, results, and conclusions are those of the authors and are independent from the funding sources. No endorsement by ICES or the Ontario MOHLTC is intended or should be inferred. Parts of this material are based on data and information compiled and provided by the Canadian Institute for Health Information (CIHI). However, the analyses, conclusions, opinions, and statements expressed herein are those of the authors, and not necessarily those of CIHI. JW holds fellowship awards from The Arthritis Society and CIHR Banting. J. Widdifield, PhD, Department of Epidemiology, Biostatistics and Occupational Health, McGill University, and Division of Clinical Epidemiology, Research Institute of the McGill University Health Centre, and Institute for Clinical Evaluative Sciences; C.S. Moura, PhD, Department of Epidemiology, Biostatistics and Occupational Health, McGill University, and Division of Clinical Epidemiology, Research Institute of the McGill University Health Centre; Y. Wang, PhD(c), Department of Epidemiology, Biostatistics and Occupational Health, McGill University; M. Abrahamowicz, PhD, Department of Epidemiology, Biostatistics and Occupational Health, McGill University; J.M. Paterson, MSc, Institute for Clinical Evaluative Sciences, and University of Toronto, Institute of Health Policy, Management and Evaluation, and Department of Family Medicine, McMaster University; A. Huang, MSc, Institute for Clinical Evaluative Sciences; M.E. Beauchamp, PhD, Division of Clinical Epidemiology, Research Institute of the McGill University Health Centre; G. Boire, MD, FRCPC, MSc, Department of Medicine, Université de Sherbrooke; P.R. Fortin, MD, FRCPC, MPH, Division of Rheumatology, Department of Medicine, Centre de recherche du CHU de Québec, Université Laval; L. Bessette, MD, FRCPC, MSc, Division of Rheumatology, Department of Medicine, Centre de recherche du CHU de Québec, Université Laval; C. Bombardier, MD, FRCPC, Division of Rheumatology, University of Toronto; J.G. Hanly, MD, FRCPC, Division of Rheumatology, Departments of Medicine and Pathology, Dalhousie University; D. Feldman, PT, PhD, École de Réadaptation, Université de Montréal; S. Bernatsky, MD, FRCPC, PhD, Department of Epidemiology, Biostatistics and Occupational Health, McGill University, and Division of Clinical Epidemiology, Research Institute of the McGill University Health Centre. Address correspondence to Dr. Jessica Widdifield, Division of Clinical Epidemiology, Research Institute of the McGill University Health Centre, 687 Pine Avenue West, V Building, Montreal, Quebec, Canada, H3A 1A1. E-mail: Jessica.widdifield@alum.utoronto.ca. Accepted for publication January 8, 2016.
Louis Bessette
From the Department of Epidemiology, Biostatistics and Occupational Health, McGill University; Division of Clinical Epidemiology, Research Institute of the McGill University Health Centre; École de Réadaptation, Université de Montréal, Montreal; Department of Medicine, Université de Sherbrooke, Sherbrooke; Division of Rheumatology, Department of Medicine, Centre de recherche du CHU de Québec, Université Laval, Quebec City, Quebec; Institute for Clinical Evaluative Sciences, University of Toronto; Institute of Health Policy, Management and Evaluation; Division of Rheumatology, University of Toronto, Toronto; Department of Family Medicine, McMaster University, Hamilton, Ontario; Division of Rheumatology, Departments of Medicine and Pathology, Dalhousie University, Halifax, Nova Scotia, Canada. Supported by The CAnadian Network for Advanced Interdisciplinary Methods for comparative effectiveness research (CAN-AIM) group (www.canaim.ca), which is funded by the Canadian Institutes of Health Research (CIHR), through the Drug Safety and Effectiveness Network; this study was supported by the Institute for Clinical Evaluative Sciences (ICES), a non-profit research corporation funded by the Ontario Ministry of Health and Long-Term Care (MOHLTC). The opinions, results, and conclusions are those of the authors and are independent from the funding sources. No endorsement by ICES or the Ontario MOHLTC is intended or should be inferred. Parts of this material are based on data and information compiled and provided by the Canadian Institute for Health Information (CIHI). However, the analyses, conclusions, opinions, and statements expressed herein are those of the authors, and not necessarily those of CIHI. JW holds fellowship awards from The Arthritis Society and CIHR Banting. J. Widdifield, PhD, Department of Epidemiology, Biostatistics and Occupational Health, McGill University, and Division of Clinical Epidemiology, Research Institute of the McGill University Health Centre, and Institute for Clinical Evaluative Sciences; C.S. Moura, PhD, Department of Epidemiology, Biostatistics and Occupational Health, McGill University, and Division of Clinical Epidemiology, Research Institute of the McGill University Health Centre; Y. Wang, PhD(c), Department of Epidemiology, Biostatistics and Occupational Health, McGill University; M. Abrahamowicz, PhD, Department of Epidemiology, Biostatistics and Occupational Health, McGill University; J.M. Paterson, MSc, Institute for Clinical Evaluative Sciences, and University of Toronto, Institute of Health Policy, Management and Evaluation, and Department of Family Medicine, McMaster University; A. Huang, MSc, Institute for Clinical Evaluative Sciences; M.E. Beauchamp, PhD, Division of Clinical Epidemiology, Research Institute of the McGill University Health Centre; G. Boire, MD, FRCPC, MSc, Department of Medicine, Université de Sherbrooke; P.R. Fortin, MD, FRCPC, MPH, Division of Rheumatology, Department of Medicine, Centre de recherche du CHU de Québec, Université Laval; L. Bessette, MD, FRCPC, MSc, Division of Rheumatology, Department of Medicine, Centre de recherche du CHU de Québec, Université Laval; C. Bombardier, MD, FRCPC, Division of Rheumatology, University of Toronto; J.G. Hanly, MD, FRCPC, Division of Rheumatology, Departments of Medicine and Pathology, Dalhousie University; D. Feldman, PT, PhD, École de Réadaptation, Université de Montréal; S. Bernatsky, MD, FRCPC, PhD, Department of Epidemiology, Biostatistics and Occupational Health, McGill University, and Division of Clinical Epidemiology, Research Institute of the McGill University Health Centre. Address correspondence to Dr. Jessica Widdifield, Division of Clinical Epidemiology, Research Institute of the McGill University Health Centre, 687 Pine Avenue West, V Building, Montreal, Quebec, Canada, H3A 1A1. E-mail: Jessica.widdifield@alum.utoronto.ca. Accepted for publication January 8, 2016.
Claire Bombardier
From the Department of Epidemiology, Biostatistics and Occupational Health, McGill University; Division of Clinical Epidemiology, Research Institute of the McGill University Health Centre; École de Réadaptation, Université de Montréal, Montreal; Department of Medicine, Université de Sherbrooke, Sherbrooke; Division of Rheumatology, Department of Medicine, Centre de recherche du CHU de Québec, Université Laval, Quebec City, Quebec; Institute for Clinical Evaluative Sciences, University of Toronto; Institute of Health Policy, Management and Evaluation; Division of Rheumatology, University of Toronto, Toronto; Department of Family Medicine, McMaster University, Hamilton, Ontario; Division of Rheumatology, Departments of Medicine and Pathology, Dalhousie University, Halifax, Nova Scotia, Canada. Supported by The CAnadian Network for Advanced Interdisciplinary Methods for comparative effectiveness research (CAN-AIM) group (www.canaim.ca), which is funded by the Canadian Institutes of Health Research (CIHR), through the Drug Safety and Effectiveness Network; this study was supported by the Institute for Clinical Evaluative Sciences (ICES), a non-profit research corporation funded by the Ontario Ministry of Health and Long-Term Care (MOHLTC). The opinions, results, and conclusions are those of the authors and are independent from the funding sources. No endorsement by ICES or the Ontario MOHLTC is intended or should be inferred. Parts of this material are based on data and information compiled and provided by the Canadian Institute for Health Information (CIHI). However, the analyses, conclusions, opinions, and statements expressed herein are those of the authors, and not necessarily those of CIHI. JW holds fellowship awards from The Arthritis Society and CIHR Banting. J. Widdifield, PhD, Department of Epidemiology, Biostatistics and Occupational Health, McGill University, and Division of Clinical Epidemiology, Research Institute of the McGill University Health Centre, and Institute for Clinical Evaluative Sciences; C.S. Moura, PhD, Department of Epidemiology, Biostatistics and Occupational Health, McGill University, and Division of Clinical Epidemiology, Research Institute of the McGill University Health Centre; Y. Wang, PhD(c), Department of Epidemiology, Biostatistics and Occupational Health, McGill University; M. Abrahamowicz, PhD, Department of Epidemiology, Biostatistics and Occupational Health, McGill University; J.M. Paterson, MSc, Institute for Clinical Evaluative Sciences, and University of Toronto, Institute of Health Policy, Management and Evaluation, and Department of Family Medicine, McMaster University; A. Huang, MSc, Institute for Clinical Evaluative Sciences; M.E. Beauchamp, PhD, Division of Clinical Epidemiology, Research Institute of the McGill University Health Centre; G. Boire, MD, FRCPC, MSc, Department of Medicine, Université de Sherbrooke; P.R. Fortin, MD, FRCPC, MPH, Division of Rheumatology, Department of Medicine, Centre de recherche du CHU de Québec, Université Laval; L. Bessette, MD, FRCPC, MSc, Division of Rheumatology, Department of Medicine, Centre de recherche du CHU de Québec, Université Laval; C. Bombardier, MD, FRCPC, Division of Rheumatology, University of Toronto; J.G. Hanly, MD, FRCPC, Division of Rheumatology, Departments of Medicine and Pathology, Dalhousie University; D. Feldman, PT, PhD, École de Réadaptation, Université de Montréal; S. Bernatsky, MD, FRCPC, PhD, Department of Epidemiology, Biostatistics and Occupational Health, McGill University, and Division of Clinical Epidemiology, Research Institute of the McGill University Health Centre. Address correspondence to Dr. Jessica Widdifield, Division of Clinical Epidemiology, Research Institute of the McGill University Health Centre, 687 Pine Avenue West, V Building, Montreal, Quebec, Canada, H3A 1A1. E-mail: Jessica.widdifield@alum.utoronto.ca. Accepted for publication January 8, 2016.
John G. Hanly
From the Department of Epidemiology, Biostatistics and Occupational Health, McGill University; Division of Clinical Epidemiology, Research Institute of the McGill University Health Centre; École de Réadaptation, Université de Montréal, Montreal; Department of Medicine, Université de Sherbrooke, Sherbrooke; Division of Rheumatology, Department of Medicine, Centre de recherche du CHU de Québec, Université Laval, Quebec City, Quebec; Institute for Clinical Evaluative Sciences, University of Toronto; Institute of Health Policy, Management and Evaluation; Division of Rheumatology, University of Toronto, Toronto; Department of Family Medicine, McMaster University, Hamilton, Ontario; Division of Rheumatology, Departments of Medicine and Pathology, Dalhousie University, Halifax, Nova Scotia, Canada. Supported by The CAnadian Network for Advanced Interdisciplinary Methods for comparative effectiveness research (CAN-AIM) group (www.canaim.ca), which is funded by the Canadian Institutes of Health Research (CIHR), through the Drug Safety and Effectiveness Network; this study was supported by the Institute for Clinical Evaluative Sciences (ICES), a non-profit research corporation funded by the Ontario Ministry of Health and Long-Term Care (MOHLTC). The opinions, results, and conclusions are those of the authors and are independent from the funding sources. No endorsement by ICES or the Ontario MOHLTC is intended or should be inferred. Parts of this material are based on data and information compiled and provided by the Canadian Institute for Health Information (CIHI). However, the analyses, conclusions, opinions, and statements expressed herein are those of the authors, and not necessarily those of CIHI. JW holds fellowship awards from The Arthritis Society and CIHR Banting. J. Widdifield, PhD, Department of Epidemiology, Biostatistics and Occupational Health, McGill University, and Division of Clinical Epidemiology, Research Institute of the McGill University Health Centre, and Institute for Clinical Evaluative Sciences; C.S. Moura, PhD, Department of Epidemiology, Biostatistics and Occupational Health, McGill University, and Division of Clinical Epidemiology, Research Institute of the McGill University Health Centre; Y. Wang, PhD(c), Department of Epidemiology, Biostatistics and Occupational Health, McGill University; M. Abrahamowicz, PhD, Department of Epidemiology, Biostatistics and Occupational Health, McGill University; J.M. Paterson, MSc, Institute for Clinical Evaluative Sciences, and University of Toronto, Institute of Health Policy, Management and Evaluation, and Department of Family Medicine, McMaster University; A. Huang, MSc, Institute for Clinical Evaluative Sciences; M.E. Beauchamp, PhD, Division of Clinical Epidemiology, Research Institute of the McGill University Health Centre; G. Boire, MD, FRCPC, MSc, Department of Medicine, Université de Sherbrooke; P.R. Fortin, MD, FRCPC, MPH, Division of Rheumatology, Department of Medicine, Centre de recherche du CHU de Québec, Université Laval; L. Bessette, MD, FRCPC, MSc, Division of Rheumatology, Department of Medicine, Centre de recherche du CHU de Québec, Université Laval; C. Bombardier, MD, FRCPC, Division of Rheumatology, University of Toronto; J.G. Hanly, MD, FRCPC, Division of Rheumatology, Departments of Medicine and Pathology, Dalhousie University; D. Feldman, PT, PhD, École de Réadaptation, Université de Montréal; S. Bernatsky, MD, FRCPC, PhD, Department of Epidemiology, Biostatistics and Occupational Health, McGill University, and Division of Clinical Epidemiology, Research Institute of the McGill University Health Centre. Address correspondence to Dr. Jessica Widdifield, Division of Clinical Epidemiology, Research Institute of the McGill University Health Centre, 687 Pine Avenue West, V Building, Montreal, Quebec, Canada, H3A 1A1. E-mail: Jessica.widdifield@alum.utoronto.ca. Accepted for publication January 8, 2016.
Debbie Feldman
From the Department of Epidemiology, Biostatistics and Occupational Health, McGill University; Division of Clinical Epidemiology, Research Institute of the McGill University Health Centre; École de Réadaptation, Université de Montréal, Montreal; Department of Medicine, Université de Sherbrooke, Sherbrooke; Division of Rheumatology, Department of Medicine, Centre de recherche du CHU de Québec, Université Laval, Quebec City, Quebec; Institute for Clinical Evaluative Sciences, University of Toronto; Institute of Health Policy, Management and Evaluation; Division of Rheumatology, University of Toronto, Toronto; Department of Family Medicine, McMaster University, Hamilton, Ontario; Division of Rheumatology, Departments of Medicine and Pathology, Dalhousie University, Halifax, Nova Scotia, Canada. Supported by The CAnadian Network for Advanced Interdisciplinary Methods for comparative effectiveness research (CAN-AIM) group (www.canaim.ca), which is funded by the Canadian Institutes of Health Research (CIHR), through the Drug Safety and Effectiveness Network; this study was supported by the Institute for Clinical Evaluative Sciences (ICES), a non-profit research corporation funded by the Ontario Ministry of Health and Long-Term Care (MOHLTC). The opinions, results, and conclusions are those of the authors and are independent from the funding sources. No endorsement by ICES or the Ontario MOHLTC is intended or should be inferred. Parts of this material are based on data and information compiled and provided by the Canadian Institute for Health Information (CIHI). However, the analyses, conclusions, opinions, and statements expressed herein are those of the authors, and not necessarily those of CIHI. JW holds fellowship awards from The Arthritis Society and CIHR Banting. J. Widdifield, PhD, Department of Epidemiology, Biostatistics and Occupational Health, McGill University, and Division of Clinical Epidemiology, Research Institute of the McGill University Health Centre, and Institute for Clinical Evaluative Sciences; C.S. Moura, PhD, Department of Epidemiology, Biostatistics and Occupational Health, McGill University, and Division of Clinical Epidemiology, Research Institute of the McGill University Health Centre; Y. Wang, PhD(c), Department of Epidemiology, Biostatistics and Occupational Health, McGill University; M. Abrahamowicz, PhD, Department of Epidemiology, Biostatistics and Occupational Health, McGill University; J.M. Paterson, MSc, Institute for Clinical Evaluative Sciences, and University of Toronto, Institute of Health Policy, Management and Evaluation, and Department of Family Medicine, McMaster University; A. Huang, MSc, Institute for Clinical Evaluative Sciences; M.E. Beauchamp, PhD, Division of Clinical Epidemiology, Research Institute of the McGill University Health Centre; G. Boire, MD, FRCPC, MSc, Department of Medicine, Université de Sherbrooke; P.R. Fortin, MD, FRCPC, MPH, Division of Rheumatology, Department of Medicine, Centre de recherche du CHU de Québec, Université Laval; L. Bessette, MD, FRCPC, MSc, Division of Rheumatology, Department of Medicine, Centre de recherche du CHU de Québec, Université Laval; C. Bombardier, MD, FRCPC, Division of Rheumatology, University of Toronto; J.G. Hanly, MD, FRCPC, Division of Rheumatology, Departments of Medicine and Pathology, Dalhousie University; D. Feldman, PT, PhD, École de Réadaptation, Université de Montréal; S. Bernatsky, MD, FRCPC, PhD, Department of Epidemiology, Biostatistics and Occupational Health, McGill University, and Division of Clinical Epidemiology, Research Institute of the McGill University Health Centre. Address correspondence to Dr. Jessica Widdifield, Division of Clinical Epidemiology, Research Institute of the McGill University Health Centre, 687 Pine Avenue West, V Building, Montreal, Quebec, Canada, H3A 1A1. E-mail: Jessica.widdifield@alum.utoronto.ca. Accepted for publication January 8, 2016.
Sasha Bernatsky
From the Department of Epidemiology, Biostatistics and Occupational Health, McGill University; Division of Clinical Epidemiology, Research Institute of the McGill University Health Centre; École de Réadaptation, Université de Montréal, Montreal; Department of Medicine, Université de Sherbrooke, Sherbrooke; Division of Rheumatology, Department of Medicine, Centre de recherche du CHU de Québec, Université Laval, Quebec City, Quebec; Institute for Clinical Evaluative Sciences, University of Toronto; Institute of Health Policy, Management and Evaluation; Division of Rheumatology, University of Toronto, Toronto; Department of Family Medicine, McMaster University, Hamilton, Ontario; Division of Rheumatology, Departments of Medicine and Pathology, Dalhousie University, Halifax, Nova Scotia, Canada. Supported by The CAnadian Network for Advanced Interdisciplinary Methods for comparative effectiveness research (CAN-AIM) group (www.canaim.ca), which is funded by the Canadian Institutes of Health Research (CIHR), through the Drug Safety and Effectiveness Network; this study was supported by the Institute for Clinical Evaluative Sciences (ICES), a non-profit research corporation funded by the Ontario Ministry of Health and Long-Term Care (MOHLTC). The opinions, results, and conclusions are those of the authors and are independent from the funding sources. No endorsement by ICES or the Ontario MOHLTC is intended or should be inferred. Parts of this material are based on data and information compiled and provided by the Canadian Institute for Health Information (CIHI). However, the analyses, conclusions, opinions, and statements expressed herein are those of the authors, and not necessarily those of CIHI. JW holds fellowship awards from The Arthritis Society and CIHR Banting. J. Widdifield, PhD, Department of Epidemiology, Biostatistics and Occupational Health, McGill University, and Division of Clinical Epidemiology, Research Institute of the McGill University Health Centre, and Institute for Clinical Evaluative Sciences; C.S. Moura, PhD, Department of Epidemiology, Biostatistics and Occupational Health, McGill University, and Division of Clinical Epidemiology, Research Institute of the McGill University Health Centre; Y. Wang, PhD(c), Department of Epidemiology, Biostatistics and Occupational Health, McGill University; M. Abrahamowicz, PhD, Department of Epidemiology, Biostatistics and Occupational Health, McGill University; J.M. Paterson, MSc, Institute for Clinical Evaluative Sciences, and University of Toronto, Institute of Health Policy, Management and Evaluation, and Department of Family Medicine, McMaster University; A. Huang, MSc, Institute for Clinical Evaluative Sciences; M.E. Beauchamp, PhD, Division of Clinical Epidemiology, Research Institute of the McGill University Health Centre; G. Boire, MD, FRCPC, MSc, Department of Medicine, Université de Sherbrooke; P.R. Fortin, MD, FRCPC, MPH, Division of Rheumatology, Department of Medicine, Centre de recherche du CHU de Québec, Université Laval; L. Bessette, MD, FRCPC, MSc, Division of Rheumatology, Department of Medicine, Centre de recherche du CHU de Québec, Université Laval; C. Bombardier, MD, FRCPC, Division of Rheumatology, University of Toronto; J.G. Hanly, MD, FRCPC, Division of Rheumatology, Departments of Medicine and Pathology, Dalhousie University; D. Feldman, PT, PhD, École de Réadaptation, Université de Montréal; S. Bernatsky, MD, FRCPC, PhD, Department of Epidemiology, Biostatistics and Occupational Health, McGill University, and Division of Clinical Epidemiology, Research Institute of the McGill University Health Centre. Address correspondence to Dr. Jessica Widdifield, Division of Clinical Epidemiology, Research Institute of the McGill University Health Centre, 687 Pine Avenue West, V Building, Montreal, Quebec, Canada, H3A 1A1. E-mail: Jessica.widdifield@alum.utoronto.ca. Accepted for publication January 8, 2016.
From the Department of Epidemiology, Biostatistics and Occupational Health, McGill University; Division of Clinical Epidemiology, Research Institute of the McGill University Health Centre; École de Réadaptation, Université de Montréal, Montreal; Department of Medicine, Université de Sherbrooke, Sherbrooke; Division of Rheumatology, Department of Medicine, Centre de recherche du CHU de Québec, Université Laval, Quebec City, Quebec; Institute for Clinical Evaluative Sciences, University of Toronto; Institute of Health Policy, Management and Evaluation; Division of Rheumatology, University of Toronto, Toronto; Department of Family Medicine, McMaster University, Hamilton, Ontario; Division of Rheumatology, Departments of Medicine and Pathology, Dalhousie University, Halifax, Nova Scotia, Canada. Supported by The CAnadian Network for Advanced Interdisciplinary Methods for comparative effectiveness research (CAN-AIM) group (www.canaim.ca), which is funded by the Canadian Institutes of Health Research (CIHR), through the Drug Safety and Effectiveness Network; this study was supported by the Institute for Clinical Evaluative Sciences (ICES), a non-profit research corporation funded by the Ontario Ministry of Health and Long-Term Care (MOHLTC). The opinions, results, and conclusions are those of the authors and are independent from the funding sources. No endorsement by ICES or the Ontario MOHLTC is intended or should be inferred. Parts of this material are based on data and information compiled and provided by the Canadian Institute for Health Information (CIHI). However, the analyses, conclusions, opinions, and statements expressed herein are those of the authors, and not necessarily those of CIHI. JW holds fellowship awards from The Arthritis Society and CIHR Banting. J. Widdifield, PhD, Department of Epidemiology, Biostatistics and Occupational Health, McGill University, and Division of Clinical Epidemiology, Research Institute of the McGill University Health Centre, and Institute for Clinical Evaluative Sciences; C.S. Moura, PhD, Department of Epidemiology, Biostatistics and Occupational Health, McGill University, and Division of Clinical Epidemiology, Research Institute of the McGill University Health Centre; Y. Wang, PhD(c), Department of Epidemiology, Biostatistics and Occupational Health, McGill University; M. Abrahamowicz, PhD, Department of Epidemiology, Biostatistics and Occupational Health, McGill University; J.M. Paterson, MSc, Institute for Clinical Evaluative Sciences, and University of Toronto, Institute of Health Policy, Management and Evaluation, and Department of Family Medicine, McMaster University; A. Huang, MSc, Institute for Clinical Evaluative Sciences; M.E. Beauchamp, PhD, Division of Clinical Epidemiology, Research Institute of the McGill University Health Centre; G. Boire, MD, FRCPC, MSc, Department of Medicine, Université de Sherbrooke; P.R. Fortin, MD, FRCPC, MPH, Division of Rheumatology, Department of Medicine, Centre de recherche du CHU de Québec, Université Laval; L. Bessette, MD, FRCPC, MSc, Division of Rheumatology, Department of Medicine, Centre de recherche du CHU de Québec, Université Laval; C. Bombardier, MD, FRCPC, Division of Rheumatology, University of Toronto; J.G. Hanly, MD, FRCPC, Division of Rheumatology, Departments of Medicine and Pathology, Dalhousie University; D. Feldman, PT, PhD, École de Réadaptation, Université de Montréal; S. Bernatsky, MD, FRCPC, PhD, Department of Epidemiology, Biostatistics and Occupational Health, McGill University, and Division of Clinical Epidemiology, Research Institute of the McGill University Health Centre. Address correspondence to Dr. Jessica Widdifield, Division of Clinical Epidemiology, Research Institute of the McGill University Health Centre, 687 Pine Avenue West, V Building, Montreal, Quebec, Canada, H3A 1A1. E-mail: Jessica.widdifield@alum.utoronto.ca. Accepted for publication January 8, 2016.
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In this issue
The Journal of Rheumatology
Vol. 51, Issue 3
1 Mar 2024
The Longterm Effect of Early Intensive Treatment of Seniors with Rheumatoid Arthritis: A Comparison of 2 Population-based Cohort Studies on Time to Joint Replacement Surgery
Jessica Widdifield, Cristiano S. Moura, Yishu Wang, Michal Abrahamowicz, J. Michael Paterson, Anjie Huang, Marie-Eve Beauchamp, Gilles Boire, Paul R. Fortin, Louis Bessette, Claire Bombardier, John G. Hanly, Debbie Feldman, Sasha Bernatsky, the CAnadian Network for Advanced Interdisciplinary Methods for comparative effectiveness research (CAN-AIM)
The Journal of Rheumatology Feb 2016, jrheum.151156; DOI: 10.3899/jrheum.151156
The Longterm Effect of Early Intensive Treatment of Seniors with Rheumatoid Arthritis: A Comparison of 2 Population-based Cohort Studies on Time to Joint Replacement Surgery
Jessica Widdifield, Cristiano S. Moura, Yishu Wang, Michal Abrahamowicz, J. Michael Paterson, Anjie Huang, Marie-Eve Beauchamp, Gilles Boire, Paul R. Fortin, Louis Bessette, Claire Bombardier, John G. Hanly, Debbie Feldman, Sasha Bernatsky, the CAnadian Network for Advanced Interdisciplinary Methods for comparative effectiveness research (CAN-AIM)
The Journal of Rheumatology Feb 2016, jrheum.151156; DOI: 10.3899/jrheum.151156