Research ArticleArticle
GREM1 Is a Key Regulator of Synoviocyte Hyperplasia and Invasiveness
Eun-Jin Han, Seung-Ah Yoo, Gi-Myo Kim, Daehee Hwang, Chul-Soo Cho, Sungyong You and Wan-Uk Kim
The Journal of Rheumatology February 2016, jrheum.150523; DOI: https://doi.org/10.3899/jrheum.150523
Eun-Jin Han
From the POSTECH-CATHOLIC Biomedical Engineering Institute, and Department of Internal Medicine, Catholic University of Korea, Seoul; Center for Systems Biology of Plant Senescence and Life History, Institute for Basic Science, Daegu Gyeongbuk Institute of Science and Technology (DGIST), Daegu, Korea; Department of Surgery and Biomedical Sciences, Cancer Biology Program, Samuel Oschin Comprehensive Cancer Institute, Cedars-Sinai Medical Center, Los Angeles, California, USA. Supported by grants from the Korea Healthcare Technology R&D Project, Ministry for Health, Welfare and Family Affairs (No. HI14C3417) and the National Research Foundation of Korea funded by the Ministry of Education, Science and Technology (2014R1A2A1A11049812, 2014R1A6A3A04054066, and 2015R1A3A2032927). E.J. Han, PhD Candidate, POSTECH-CATHOLIC Biomedical Engineering Institute, Catholic University of Korea; S.A. Yoo, PhD, POSTECH-CATHOLIC Biomedical Engineering Institute, Catholic University of Korea; G.M. Kim, PhD Candidate, POSTECH-CATHOLIC Biomedical Engineering Institute, Catholic University of Korea; D. Hwang, PhD, Center for Systems Biology of Plant Senescence and Life History, Institute for Basic Science, DGIST; C.S. Cho, MD, PhD, POSTECH-CATHOLIC Biomedical Engineering Institute, Catholic University of Korea; S. You, PhD, Department of Surgery and Biomedical Sciences, Cancer Biology Program, Samuel Oschin Comprehensive Cancer Institute, Cedars-Sinai Medical Center; W.U. Kim, MD, PhD, POSTECH-CATHOLIC Biomedical Engineering Institute, and Department of Internal Medicine, Catholic University of Korea. Address correspondence to Dr. W.U. Kim, Department of Internal Medicine, Division of Rheumatology, Catholic University of Korea, School of Medicine, Seoul, 137-701, Korea. E-mail: wan725@catholic.ac.kr. Or: Dr. S. You, Department of Surgery and Biomedical Sciences, Samuel Oschin Comprehensive Cancer Institute, Cedars-Sinai Medical Center, Los Angeles, California 90048, USA. E-mail: Sungyong.You@cshs.org. Accepted for publication October 13, 2015.
Seung-Ah Yoo
From the POSTECH-CATHOLIC Biomedical Engineering Institute, and Department of Internal Medicine, Catholic University of Korea, Seoul; Center for Systems Biology of Plant Senescence and Life History, Institute for Basic Science, Daegu Gyeongbuk Institute of Science and Technology (DGIST), Daegu, Korea; Department of Surgery and Biomedical Sciences, Cancer Biology Program, Samuel Oschin Comprehensive Cancer Institute, Cedars-Sinai Medical Center, Los Angeles, California, USA. Supported by grants from the Korea Healthcare Technology R&D Project, Ministry for Health, Welfare and Family Affairs (No. HI14C3417) and the National Research Foundation of Korea funded by the Ministry of Education, Science and Technology (2014R1A2A1A11049812, 2014R1A6A3A04054066, and 2015R1A3A2032927). E.J. Han, PhD Candidate, POSTECH-CATHOLIC Biomedical Engineering Institute, Catholic University of Korea; S.A. Yoo, PhD, POSTECH-CATHOLIC Biomedical Engineering Institute, Catholic University of Korea; G.M. Kim, PhD Candidate, POSTECH-CATHOLIC Biomedical Engineering Institute, Catholic University of Korea; D. Hwang, PhD, Center for Systems Biology of Plant Senescence and Life History, Institute for Basic Science, DGIST; C.S. Cho, MD, PhD, POSTECH-CATHOLIC Biomedical Engineering Institute, Catholic University of Korea; S. You, PhD, Department of Surgery and Biomedical Sciences, Cancer Biology Program, Samuel Oschin Comprehensive Cancer Institute, Cedars-Sinai Medical Center; W.U. Kim, MD, PhD, POSTECH-CATHOLIC Biomedical Engineering Institute, and Department of Internal Medicine, Catholic University of Korea. Address correspondence to Dr. W.U. Kim, Department of Internal Medicine, Division of Rheumatology, Catholic University of Korea, School of Medicine, Seoul, 137-701, Korea. E-mail: wan725@catholic.ac.kr. Or: Dr. S. You, Department of Surgery and Biomedical Sciences, Samuel Oschin Comprehensive Cancer Institute, Cedars-Sinai Medical Center, Los Angeles, California 90048, USA. E-mail: Sungyong.You@cshs.org. Accepted for publication October 13, 2015.
Gi-Myo Kim
From the POSTECH-CATHOLIC Biomedical Engineering Institute, and Department of Internal Medicine, Catholic University of Korea, Seoul; Center for Systems Biology of Plant Senescence and Life History, Institute for Basic Science, Daegu Gyeongbuk Institute of Science and Technology (DGIST), Daegu, Korea; Department of Surgery and Biomedical Sciences, Cancer Biology Program, Samuel Oschin Comprehensive Cancer Institute, Cedars-Sinai Medical Center, Los Angeles, California, USA. Supported by grants from the Korea Healthcare Technology R&D Project, Ministry for Health, Welfare and Family Affairs (No. HI14C3417) and the National Research Foundation of Korea funded by the Ministry of Education, Science and Technology (2014R1A2A1A11049812, 2014R1A6A3A04054066, and 2015R1A3A2032927). E.J. Han, PhD Candidate, POSTECH-CATHOLIC Biomedical Engineering Institute, Catholic University of Korea; S.A. Yoo, PhD, POSTECH-CATHOLIC Biomedical Engineering Institute, Catholic University of Korea; G.M. Kim, PhD Candidate, POSTECH-CATHOLIC Biomedical Engineering Institute, Catholic University of Korea; D. Hwang, PhD, Center for Systems Biology of Plant Senescence and Life History, Institute for Basic Science, DGIST; C.S. Cho, MD, PhD, POSTECH-CATHOLIC Biomedical Engineering Institute, Catholic University of Korea; S. You, PhD, Department of Surgery and Biomedical Sciences, Cancer Biology Program, Samuel Oschin Comprehensive Cancer Institute, Cedars-Sinai Medical Center; W.U. Kim, MD, PhD, POSTECH-CATHOLIC Biomedical Engineering Institute, and Department of Internal Medicine, Catholic University of Korea. Address correspondence to Dr. W.U. Kim, Department of Internal Medicine, Division of Rheumatology, Catholic University of Korea, School of Medicine, Seoul, 137-701, Korea. E-mail: wan725@catholic.ac.kr. Or: Dr. S. You, Department of Surgery and Biomedical Sciences, Samuel Oschin Comprehensive Cancer Institute, Cedars-Sinai Medical Center, Los Angeles, California 90048, USA. E-mail: Sungyong.You@cshs.org. Accepted for publication October 13, 2015.
Daehee Hwang
From the POSTECH-CATHOLIC Biomedical Engineering Institute, and Department of Internal Medicine, Catholic University of Korea, Seoul; Center for Systems Biology of Plant Senescence and Life History, Institute for Basic Science, Daegu Gyeongbuk Institute of Science and Technology (DGIST), Daegu, Korea; Department of Surgery and Biomedical Sciences, Cancer Biology Program, Samuel Oschin Comprehensive Cancer Institute, Cedars-Sinai Medical Center, Los Angeles, California, USA. Supported by grants from the Korea Healthcare Technology R&D Project, Ministry for Health, Welfare and Family Affairs (No. HI14C3417) and the National Research Foundation of Korea funded by the Ministry of Education, Science and Technology (2014R1A2A1A11049812, 2014R1A6A3A04054066, and 2015R1A3A2032927). E.J. Han, PhD Candidate, POSTECH-CATHOLIC Biomedical Engineering Institute, Catholic University of Korea; S.A. Yoo, PhD, POSTECH-CATHOLIC Biomedical Engineering Institute, Catholic University of Korea; G.M. Kim, PhD Candidate, POSTECH-CATHOLIC Biomedical Engineering Institute, Catholic University of Korea; D. Hwang, PhD, Center for Systems Biology of Plant Senescence and Life History, Institute for Basic Science, DGIST; C.S. Cho, MD, PhD, POSTECH-CATHOLIC Biomedical Engineering Institute, Catholic University of Korea; S. You, PhD, Department of Surgery and Biomedical Sciences, Cancer Biology Program, Samuel Oschin Comprehensive Cancer Institute, Cedars-Sinai Medical Center; W.U. Kim, MD, PhD, POSTECH-CATHOLIC Biomedical Engineering Institute, and Department of Internal Medicine, Catholic University of Korea. Address correspondence to Dr. W.U. Kim, Department of Internal Medicine, Division of Rheumatology, Catholic University of Korea, School of Medicine, Seoul, 137-701, Korea. E-mail: wan725@catholic.ac.kr. Or: Dr. S. You, Department of Surgery and Biomedical Sciences, Samuel Oschin Comprehensive Cancer Institute, Cedars-Sinai Medical Center, Los Angeles, California 90048, USA. E-mail: Sungyong.You@cshs.org. Accepted for publication October 13, 2015.
Chul-Soo Cho
From the POSTECH-CATHOLIC Biomedical Engineering Institute, and Department of Internal Medicine, Catholic University of Korea, Seoul; Center for Systems Biology of Plant Senescence and Life History, Institute for Basic Science, Daegu Gyeongbuk Institute of Science and Technology (DGIST), Daegu, Korea; Department of Surgery and Biomedical Sciences, Cancer Biology Program, Samuel Oschin Comprehensive Cancer Institute, Cedars-Sinai Medical Center, Los Angeles, California, USA. Supported by grants from the Korea Healthcare Technology R&D Project, Ministry for Health, Welfare and Family Affairs (No. HI14C3417) and the National Research Foundation of Korea funded by the Ministry of Education, Science and Technology (2014R1A2A1A11049812, 2014R1A6A3A04054066, and 2015R1A3A2032927). E.J. Han, PhD Candidate, POSTECH-CATHOLIC Biomedical Engineering Institute, Catholic University of Korea; S.A. Yoo, PhD, POSTECH-CATHOLIC Biomedical Engineering Institute, Catholic University of Korea; G.M. Kim, PhD Candidate, POSTECH-CATHOLIC Biomedical Engineering Institute, Catholic University of Korea; D. Hwang, PhD, Center for Systems Biology of Plant Senescence and Life History, Institute for Basic Science, DGIST; C.S. Cho, MD, PhD, POSTECH-CATHOLIC Biomedical Engineering Institute, Catholic University of Korea; S. You, PhD, Department of Surgery and Biomedical Sciences, Cancer Biology Program, Samuel Oschin Comprehensive Cancer Institute, Cedars-Sinai Medical Center; W.U. Kim, MD, PhD, POSTECH-CATHOLIC Biomedical Engineering Institute, and Department of Internal Medicine, Catholic University of Korea. Address correspondence to Dr. W.U. Kim, Department of Internal Medicine, Division of Rheumatology, Catholic University of Korea, School of Medicine, Seoul, 137-701, Korea. E-mail: wan725@catholic.ac.kr. Or: Dr. S. You, Department of Surgery and Biomedical Sciences, Samuel Oschin Comprehensive Cancer Institute, Cedars-Sinai Medical Center, Los Angeles, California 90048, USA. E-mail: Sungyong.You@cshs.org. Accepted for publication October 13, 2015.
Sungyong You
From the POSTECH-CATHOLIC Biomedical Engineering Institute, and Department of Internal Medicine, Catholic University of Korea, Seoul; Center for Systems Biology of Plant Senescence and Life History, Institute for Basic Science, Daegu Gyeongbuk Institute of Science and Technology (DGIST), Daegu, Korea; Department of Surgery and Biomedical Sciences, Cancer Biology Program, Samuel Oschin Comprehensive Cancer Institute, Cedars-Sinai Medical Center, Los Angeles, California, USA. Supported by grants from the Korea Healthcare Technology R&D Project, Ministry for Health, Welfare and Family Affairs (No. HI14C3417) and the National Research Foundation of Korea funded by the Ministry of Education, Science and Technology (2014R1A2A1A11049812, 2014R1A6A3A04054066, and 2015R1A3A2032927). E.J. Han, PhD Candidate, POSTECH-CATHOLIC Biomedical Engineering Institute, Catholic University of Korea; S.A. Yoo, PhD, POSTECH-CATHOLIC Biomedical Engineering Institute, Catholic University of Korea; G.M. Kim, PhD Candidate, POSTECH-CATHOLIC Biomedical Engineering Institute, Catholic University of Korea; D. Hwang, PhD, Center for Systems Biology of Plant Senescence and Life History, Institute for Basic Science, DGIST; C.S. Cho, MD, PhD, POSTECH-CATHOLIC Biomedical Engineering Institute, Catholic University of Korea; S. You, PhD, Department of Surgery and Biomedical Sciences, Cancer Biology Program, Samuel Oschin Comprehensive Cancer Institute, Cedars-Sinai Medical Center; W.U. Kim, MD, PhD, POSTECH-CATHOLIC Biomedical Engineering Institute, and Department of Internal Medicine, Catholic University of Korea. Address correspondence to Dr. W.U. Kim, Department of Internal Medicine, Division of Rheumatology, Catholic University of Korea, School of Medicine, Seoul, 137-701, Korea. E-mail: wan725@catholic.ac.kr. Or: Dr. S. You, Department of Surgery and Biomedical Sciences, Samuel Oschin Comprehensive Cancer Institute, Cedars-Sinai Medical Center, Los Angeles, California 90048, USA. E-mail: Sungyong.You@cshs.org. Accepted for publication October 13, 2015.
Wan-Uk Kim
From the POSTECH-CATHOLIC Biomedical Engineering Institute, and Department of Internal Medicine, Catholic University of Korea, Seoul; Center for Systems Biology of Plant Senescence and Life History, Institute for Basic Science, Daegu Gyeongbuk Institute of Science and Technology (DGIST), Daegu, Korea; Department of Surgery and Biomedical Sciences, Cancer Biology Program, Samuel Oschin Comprehensive Cancer Institute, Cedars-Sinai Medical Center, Los Angeles, California, USA. Supported by grants from the Korea Healthcare Technology R&D Project, Ministry for Health, Welfare and Family Affairs (No. HI14C3417) and the National Research Foundation of Korea funded by the Ministry of Education, Science and Technology (2014R1A2A1A11049812, 2014R1A6A3A04054066, and 2015R1A3A2032927). E.J. Han, PhD Candidate, POSTECH-CATHOLIC Biomedical Engineering Institute, Catholic University of Korea; S.A. Yoo, PhD, POSTECH-CATHOLIC Biomedical Engineering Institute, Catholic University of Korea; G.M. Kim, PhD Candidate, POSTECH-CATHOLIC Biomedical Engineering Institute, Catholic University of Korea; D. Hwang, PhD, Center for Systems Biology of Plant Senescence and Life History, Institute for Basic Science, DGIST; C.S. Cho, MD, PhD, POSTECH-CATHOLIC Biomedical Engineering Institute, Catholic University of Korea; S. You, PhD, Department of Surgery and Biomedical Sciences, Cancer Biology Program, Samuel Oschin Comprehensive Cancer Institute, Cedars-Sinai Medical Center; W.U. Kim, MD, PhD, POSTECH-CATHOLIC Biomedical Engineering Institute, and Department of Internal Medicine, Catholic University of Korea. Address correspondence to Dr. W.U. Kim, Department of Internal Medicine, Division of Rheumatology, Catholic University of Korea, School of Medicine, Seoul, 137-701, Korea. E-mail: wan725@catholic.ac.kr. Or: Dr. S. You, Department of Surgery and Biomedical Sciences, Samuel Oschin Comprehensive Cancer Institute, Cedars-Sinai Medical Center, Los Angeles, California 90048, USA. E-mail: Sungyong.You@cshs.org. Accepted for publication October 13, 2015.
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In this issue
The Journal of Rheumatology
Vol. 51, Issue 4
1 Apr 2024
GREM1 Is a Key Regulator of Synoviocyte Hyperplasia and Invasiveness
Eun-Jin Han, Seung-Ah Yoo, Gi-Myo Kim, Daehee Hwang, Chul-Soo Cho, Sungyong You, Wan-Uk Kim
The Journal of Rheumatology Feb 2016, jrheum.150523; DOI: 10.3899/jrheum.150523