Research ArticleArticle
High Kellgren-Lawrence Grade and Bone Marrow Lesions Predict Worsening Rates of Radiographic Joint Space Narrowing; The SEKOIA Study
Mark H. Edwards, Camille Parsons, Olivier Bruyère, Forence Petit Dop, Roland Chapurlat, Frank W. Roemer, Ali Guermazi, Souhil Zaim, Harry Genant, Jean-Yves Reginster, Elaine M. Dennison, Cyrus Cooper and and the SEKOIA Study Group
The Journal of Rheumatology January 2016, jrheum.150053; DOI: https://doi.org/10.3899/jrheum.150053
Mark H. Edwards
From the MRC Lifecourse Epidemiology Unit, University of Southampton, Southampton, UK; Department of Public Health and Health Economics, University of Liege, Liege, Belgium; Innovative Therapeutic Pole of Rheumatology, Servier, Surenes, France; INSERM UMR 1033, Service de Rhumatolgie et Pathologie Osseuse, Hôpital Edouard Herriot, Université de Lyon, Lyon, France; Quantitative Imaging Center, Department of Radiology, Boston University School of Medicine, Boston, Massachusetts, USA; Department of Radiology, University of Erlangen-Nuremburg, Erlangen, Germany; Synarc, San Francisco, California, USA; Department of Public Health and Health Economics, University of Liege; NIHR Biomedical Research Centre, University of Southampton and University Hospital Southampton NHS Foundation Trust, Southampton General Hospital; and NIHR Musculoskeletal Biomedical Research Unit, Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences, University of Oxford, Oxford, UK. Supported by the Medical Research Council of Great Britain; Arthritis Research UK; and the International Osteoporosis Foundation; and by the National Institute of Health Research Nutrition Biomedical Research Centre, University of Southampton and the National Institute of Health Research Musculoskeletal Biomedical Research Unit, University of Oxford. Dr. Edwards is supported by an Arthritis Research UK Clinical PhD Studentship. M.H. Edwards, MD, PhD; C. Parsons, MSc, MRC Lifecourse Epidemiology Unit, University of Southampton; O. Bruyère, PhD, Department of Public Health and Health Economics, University of Liege; F. Petit Dop, PhD, Innovative Therapeutic Pole of Rheumatology; R. Chapurlat, MD, PhD, INSERM UMR 1033, Service de Rhumatolgie et Pathologie Osseuse, Hôpital Edouard Herriot, Université de Lyon; F.W. Roemer, MD, Quantitative Imaging Center, Department of Radiology, Boston University School of Medicine; Department of Radiology, University of Erlangen-Nuremburg; A. Guermazi, MD, PhD, Quantitative Imaging Center, Department of Radiology, Boston University School of Medicine; S. Zaim, MD, Synarc; H. Genant, MD, Synarc; J-Y. Reginster, MD, PhD, Department of Public Health and Health Economics, University of Liege; E.M. Dennison, MD, PhD, MRC Lifecourse Epidemiology Unit, University of Southampton; Victoria University; C. Cooper, FMedSci, MRC Lifecourse Epidemiology Unit, University of Southampton; NIHR Biomedical Research Centre, University of Southampton and University Hospital Southampton NHS Foundation Trust, Southampton General Hospital; NIHR Musculoskeletal Biomedical Research Unit, Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences, University of Oxford, Oxford, UK. C. Parsons and Dr. Edwards are joint first authors of this report. Address correspondence to Prof. C. Cooper, MRC Lifecourse Epidemiology Unit (University of Southampton), Southampton General Hospital, Southampton, SO16 6YD, UK. E-mail: cc@mrc.soton.ac.uk. Accepted for publication September 11, 2015.
Camille Parsons
From the MRC Lifecourse Epidemiology Unit, University of Southampton, Southampton, UK; Department of Public Health and Health Economics, University of Liege, Liege, Belgium; Innovative Therapeutic Pole of Rheumatology, Servier, Surenes, France; INSERM UMR 1033, Service de Rhumatolgie et Pathologie Osseuse, Hôpital Edouard Herriot, Université de Lyon, Lyon, France; Quantitative Imaging Center, Department of Radiology, Boston University School of Medicine, Boston, Massachusetts, USA; Department of Radiology, University of Erlangen-Nuremburg, Erlangen, Germany; Synarc, San Francisco, California, USA; Department of Public Health and Health Economics, University of Liege; NIHR Biomedical Research Centre, University of Southampton and University Hospital Southampton NHS Foundation Trust, Southampton General Hospital; and NIHR Musculoskeletal Biomedical Research Unit, Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences, University of Oxford, Oxford, UK. Supported by the Medical Research Council of Great Britain; Arthritis Research UK; and the International Osteoporosis Foundation; and by the National Institute of Health Research Nutrition Biomedical Research Centre, University of Southampton and the National Institute of Health Research Musculoskeletal Biomedical Research Unit, University of Oxford. Dr. Edwards is supported by an Arthritis Research UK Clinical PhD Studentship. M.H. Edwards, MD, PhD; C. Parsons, MSc, MRC Lifecourse Epidemiology Unit, University of Southampton; O. Bruyère, PhD, Department of Public Health and Health Economics, University of Liege; F. Petit Dop, PhD, Innovative Therapeutic Pole of Rheumatology; R. Chapurlat, MD, PhD, INSERM UMR 1033, Service de Rhumatolgie et Pathologie Osseuse, Hôpital Edouard Herriot, Université de Lyon; F.W. Roemer, MD, Quantitative Imaging Center, Department of Radiology, Boston University School of Medicine; Department of Radiology, University of Erlangen-Nuremburg; A. Guermazi, MD, PhD, Quantitative Imaging Center, Department of Radiology, Boston University School of Medicine; S. Zaim, MD, Synarc; H. Genant, MD, Synarc; J-Y. Reginster, MD, PhD, Department of Public Health and Health Economics, University of Liege; E.M. Dennison, MD, PhD, MRC Lifecourse Epidemiology Unit, University of Southampton; Victoria University; C. Cooper, FMedSci, MRC Lifecourse Epidemiology Unit, University of Southampton; NIHR Biomedical Research Centre, University of Southampton and University Hospital Southampton NHS Foundation Trust, Southampton General Hospital; NIHR Musculoskeletal Biomedical Research Unit, Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences, University of Oxford, Oxford, UK. C. Parsons and Dr. Edwards are joint first authors of this report. Address correspondence to Prof. C. Cooper, MRC Lifecourse Epidemiology Unit (University of Southampton), Southampton General Hospital, Southampton, SO16 6YD, UK. E-mail: cc@mrc.soton.ac.uk. Accepted for publication September 11, 2015.
Olivier Bruyère
From the MRC Lifecourse Epidemiology Unit, University of Southampton, Southampton, UK; Department of Public Health and Health Economics, University of Liege, Liege, Belgium; Innovative Therapeutic Pole of Rheumatology, Servier, Surenes, France; INSERM UMR 1033, Service de Rhumatolgie et Pathologie Osseuse, Hôpital Edouard Herriot, Université de Lyon, Lyon, France; Quantitative Imaging Center, Department of Radiology, Boston University School of Medicine, Boston, Massachusetts, USA; Department of Radiology, University of Erlangen-Nuremburg, Erlangen, Germany; Synarc, San Francisco, California, USA; Department of Public Health and Health Economics, University of Liege; NIHR Biomedical Research Centre, University of Southampton and University Hospital Southampton NHS Foundation Trust, Southampton General Hospital; and NIHR Musculoskeletal Biomedical Research Unit, Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences, University of Oxford, Oxford, UK. Supported by the Medical Research Council of Great Britain; Arthritis Research UK; and the International Osteoporosis Foundation; and by the National Institute of Health Research Nutrition Biomedical Research Centre, University of Southampton and the National Institute of Health Research Musculoskeletal Biomedical Research Unit, University of Oxford. Dr. Edwards is supported by an Arthritis Research UK Clinical PhD Studentship. M.H. Edwards, MD, PhD; C. Parsons, MSc, MRC Lifecourse Epidemiology Unit, University of Southampton; O. Bruyère, PhD, Department of Public Health and Health Economics, University of Liege; F. Petit Dop, PhD, Innovative Therapeutic Pole of Rheumatology; R. Chapurlat, MD, PhD, INSERM UMR 1033, Service de Rhumatolgie et Pathologie Osseuse, Hôpital Edouard Herriot, Université de Lyon; F.W. Roemer, MD, Quantitative Imaging Center, Department of Radiology, Boston University School of Medicine; Department of Radiology, University of Erlangen-Nuremburg; A. Guermazi, MD, PhD, Quantitative Imaging Center, Department of Radiology, Boston University School of Medicine; S. Zaim, MD, Synarc; H. Genant, MD, Synarc; J-Y. Reginster, MD, PhD, Department of Public Health and Health Economics, University of Liege; E.M. Dennison, MD, PhD, MRC Lifecourse Epidemiology Unit, University of Southampton; Victoria University; C. Cooper, FMedSci, MRC Lifecourse Epidemiology Unit, University of Southampton; NIHR Biomedical Research Centre, University of Southampton and University Hospital Southampton NHS Foundation Trust, Southampton General Hospital; NIHR Musculoskeletal Biomedical Research Unit, Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences, University of Oxford, Oxford, UK. C. Parsons and Dr. Edwards are joint first authors of this report. Address correspondence to Prof. C. Cooper, MRC Lifecourse Epidemiology Unit (University of Southampton), Southampton General Hospital, Southampton, SO16 6YD, UK. E-mail: cc@mrc.soton.ac.uk. Accepted for publication September 11, 2015.
Forence Petit Dop
From the MRC Lifecourse Epidemiology Unit, University of Southampton, Southampton, UK; Department of Public Health and Health Economics, University of Liege, Liege, Belgium; Innovative Therapeutic Pole of Rheumatology, Servier, Surenes, France; INSERM UMR 1033, Service de Rhumatolgie et Pathologie Osseuse, Hôpital Edouard Herriot, Université de Lyon, Lyon, France; Quantitative Imaging Center, Department of Radiology, Boston University School of Medicine, Boston, Massachusetts, USA; Department of Radiology, University of Erlangen-Nuremburg, Erlangen, Germany; Synarc, San Francisco, California, USA; Department of Public Health and Health Economics, University of Liege; NIHR Biomedical Research Centre, University of Southampton and University Hospital Southampton NHS Foundation Trust, Southampton General Hospital; and NIHR Musculoskeletal Biomedical Research Unit, Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences, University of Oxford, Oxford, UK. Supported by the Medical Research Council of Great Britain; Arthritis Research UK; and the International Osteoporosis Foundation; and by the National Institute of Health Research Nutrition Biomedical Research Centre, University of Southampton and the National Institute of Health Research Musculoskeletal Biomedical Research Unit, University of Oxford. Dr. Edwards is supported by an Arthritis Research UK Clinical PhD Studentship. M.H. Edwards, MD, PhD; C. Parsons, MSc, MRC Lifecourse Epidemiology Unit, University of Southampton; O. Bruyère, PhD, Department of Public Health and Health Economics, University of Liege; F. Petit Dop, PhD, Innovative Therapeutic Pole of Rheumatology; R. Chapurlat, MD, PhD, INSERM UMR 1033, Service de Rhumatolgie et Pathologie Osseuse, Hôpital Edouard Herriot, Université de Lyon; F.W. Roemer, MD, Quantitative Imaging Center, Department of Radiology, Boston University School of Medicine; Department of Radiology, University of Erlangen-Nuremburg; A. Guermazi, MD, PhD, Quantitative Imaging Center, Department of Radiology, Boston University School of Medicine; S. Zaim, MD, Synarc; H. Genant, MD, Synarc; J-Y. Reginster, MD, PhD, Department of Public Health and Health Economics, University of Liege; E.M. Dennison, MD, PhD, MRC Lifecourse Epidemiology Unit, University of Southampton; Victoria University; C. Cooper, FMedSci, MRC Lifecourse Epidemiology Unit, University of Southampton; NIHR Biomedical Research Centre, University of Southampton and University Hospital Southampton NHS Foundation Trust, Southampton General Hospital; NIHR Musculoskeletal Biomedical Research Unit, Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences, University of Oxford, Oxford, UK. C. Parsons and Dr. Edwards are joint first authors of this report. Address correspondence to Prof. C. Cooper, MRC Lifecourse Epidemiology Unit (University of Southampton), Southampton General Hospital, Southampton, SO16 6YD, UK. E-mail: cc@mrc.soton.ac.uk. Accepted for publication September 11, 2015.
Roland Chapurlat
From the MRC Lifecourse Epidemiology Unit, University of Southampton, Southampton, UK; Department of Public Health and Health Economics, University of Liege, Liege, Belgium; Innovative Therapeutic Pole of Rheumatology, Servier, Surenes, France; INSERM UMR 1033, Service de Rhumatolgie et Pathologie Osseuse, Hôpital Edouard Herriot, Université de Lyon, Lyon, France; Quantitative Imaging Center, Department of Radiology, Boston University School of Medicine, Boston, Massachusetts, USA; Department of Radiology, University of Erlangen-Nuremburg, Erlangen, Germany; Synarc, San Francisco, California, USA; Department of Public Health and Health Economics, University of Liege; NIHR Biomedical Research Centre, University of Southampton and University Hospital Southampton NHS Foundation Trust, Southampton General Hospital; and NIHR Musculoskeletal Biomedical Research Unit, Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences, University of Oxford, Oxford, UK. Supported by the Medical Research Council of Great Britain; Arthritis Research UK; and the International Osteoporosis Foundation; and by the National Institute of Health Research Nutrition Biomedical Research Centre, University of Southampton and the National Institute of Health Research Musculoskeletal Biomedical Research Unit, University of Oxford. Dr. Edwards is supported by an Arthritis Research UK Clinical PhD Studentship. M.H. Edwards, MD, PhD; C. Parsons, MSc, MRC Lifecourse Epidemiology Unit, University of Southampton; O. Bruyère, PhD, Department of Public Health and Health Economics, University of Liege; F. Petit Dop, PhD, Innovative Therapeutic Pole of Rheumatology; R. Chapurlat, MD, PhD, INSERM UMR 1033, Service de Rhumatolgie et Pathologie Osseuse, Hôpital Edouard Herriot, Université de Lyon; F.W. Roemer, MD, Quantitative Imaging Center, Department of Radiology, Boston University School of Medicine; Department of Radiology, University of Erlangen-Nuremburg; A. Guermazi, MD, PhD, Quantitative Imaging Center, Department of Radiology, Boston University School of Medicine; S. Zaim, MD, Synarc; H. Genant, MD, Synarc; J-Y. Reginster, MD, PhD, Department of Public Health and Health Economics, University of Liege; E.M. Dennison, MD, PhD, MRC Lifecourse Epidemiology Unit, University of Southampton; Victoria University; C. Cooper, FMedSci, MRC Lifecourse Epidemiology Unit, University of Southampton; NIHR Biomedical Research Centre, University of Southampton and University Hospital Southampton NHS Foundation Trust, Southampton General Hospital; NIHR Musculoskeletal Biomedical Research Unit, Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences, University of Oxford, Oxford, UK. C. Parsons and Dr. Edwards are joint first authors of this report. Address correspondence to Prof. C. Cooper, MRC Lifecourse Epidemiology Unit (University of Southampton), Southampton General Hospital, Southampton, SO16 6YD, UK. E-mail: cc@mrc.soton.ac.uk. Accepted for publication September 11, 2015.
Frank W. Roemer
From the MRC Lifecourse Epidemiology Unit, University of Southampton, Southampton, UK; Department of Public Health and Health Economics, University of Liege, Liege, Belgium; Innovative Therapeutic Pole of Rheumatology, Servier, Surenes, France; INSERM UMR 1033, Service de Rhumatolgie et Pathologie Osseuse, Hôpital Edouard Herriot, Université de Lyon, Lyon, France; Quantitative Imaging Center, Department of Radiology, Boston University School of Medicine, Boston, Massachusetts, USA; Department of Radiology, University of Erlangen-Nuremburg, Erlangen, Germany; Synarc, San Francisco, California, USA; Department of Public Health and Health Economics, University of Liege; NIHR Biomedical Research Centre, University of Southampton and University Hospital Southampton NHS Foundation Trust, Southampton General Hospital; and NIHR Musculoskeletal Biomedical Research Unit, Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences, University of Oxford, Oxford, UK. Supported by the Medical Research Council of Great Britain; Arthritis Research UK; and the International Osteoporosis Foundation; and by the National Institute of Health Research Nutrition Biomedical Research Centre, University of Southampton and the National Institute of Health Research Musculoskeletal Biomedical Research Unit, University of Oxford. Dr. Edwards is supported by an Arthritis Research UK Clinical PhD Studentship. M.H. Edwards, MD, PhD; C. Parsons, MSc, MRC Lifecourse Epidemiology Unit, University of Southampton; O. Bruyère, PhD, Department of Public Health and Health Economics, University of Liege; F. Petit Dop, PhD, Innovative Therapeutic Pole of Rheumatology; R. Chapurlat, MD, PhD, INSERM UMR 1033, Service de Rhumatolgie et Pathologie Osseuse, Hôpital Edouard Herriot, Université de Lyon; F.W. Roemer, MD, Quantitative Imaging Center, Department of Radiology, Boston University School of Medicine; Department of Radiology, University of Erlangen-Nuremburg; A. Guermazi, MD, PhD, Quantitative Imaging Center, Department of Radiology, Boston University School of Medicine; S. Zaim, MD, Synarc; H. Genant, MD, Synarc; J-Y. Reginster, MD, PhD, Department of Public Health and Health Economics, University of Liege; E.M. Dennison, MD, PhD, MRC Lifecourse Epidemiology Unit, University of Southampton; Victoria University; C. Cooper, FMedSci, MRC Lifecourse Epidemiology Unit, University of Southampton; NIHR Biomedical Research Centre, University of Southampton and University Hospital Southampton NHS Foundation Trust, Southampton General Hospital; NIHR Musculoskeletal Biomedical Research Unit, Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences, University of Oxford, Oxford, UK. C. Parsons and Dr. Edwards are joint first authors of this report. Address correspondence to Prof. C. Cooper, MRC Lifecourse Epidemiology Unit (University of Southampton), Southampton General Hospital, Southampton, SO16 6YD, UK. E-mail: cc@mrc.soton.ac.uk. Accepted for publication September 11, 2015.
Ali Guermazi
From the MRC Lifecourse Epidemiology Unit, University of Southampton, Southampton, UK; Department of Public Health and Health Economics, University of Liege, Liege, Belgium; Innovative Therapeutic Pole of Rheumatology, Servier, Surenes, France; INSERM UMR 1033, Service de Rhumatolgie et Pathologie Osseuse, Hôpital Edouard Herriot, Université de Lyon, Lyon, France; Quantitative Imaging Center, Department of Radiology, Boston University School of Medicine, Boston, Massachusetts, USA; Department of Radiology, University of Erlangen-Nuremburg, Erlangen, Germany; Synarc, San Francisco, California, USA; Department of Public Health and Health Economics, University of Liege; NIHR Biomedical Research Centre, University of Southampton and University Hospital Southampton NHS Foundation Trust, Southampton General Hospital; and NIHR Musculoskeletal Biomedical Research Unit, Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences, University of Oxford, Oxford, UK. Supported by the Medical Research Council of Great Britain; Arthritis Research UK; and the International Osteoporosis Foundation; and by the National Institute of Health Research Nutrition Biomedical Research Centre, University of Southampton and the National Institute of Health Research Musculoskeletal Biomedical Research Unit, University of Oxford. Dr. Edwards is supported by an Arthritis Research UK Clinical PhD Studentship. M.H. Edwards, MD, PhD; C. Parsons, MSc, MRC Lifecourse Epidemiology Unit, University of Southampton; O. Bruyère, PhD, Department of Public Health and Health Economics, University of Liege; F. Petit Dop, PhD, Innovative Therapeutic Pole of Rheumatology; R. Chapurlat, MD, PhD, INSERM UMR 1033, Service de Rhumatolgie et Pathologie Osseuse, Hôpital Edouard Herriot, Université de Lyon; F.W. Roemer, MD, Quantitative Imaging Center, Department of Radiology, Boston University School of Medicine; Department of Radiology, University of Erlangen-Nuremburg; A. Guermazi, MD, PhD, Quantitative Imaging Center, Department of Radiology, Boston University School of Medicine; S. Zaim, MD, Synarc; H. Genant, MD, Synarc; J-Y. Reginster, MD, PhD, Department of Public Health and Health Economics, University of Liege; E.M. Dennison, MD, PhD, MRC Lifecourse Epidemiology Unit, University of Southampton; Victoria University; C. Cooper, FMedSci, MRC Lifecourse Epidemiology Unit, University of Southampton; NIHR Biomedical Research Centre, University of Southampton and University Hospital Southampton NHS Foundation Trust, Southampton General Hospital; NIHR Musculoskeletal Biomedical Research Unit, Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences, University of Oxford, Oxford, UK. C. Parsons and Dr. Edwards are joint first authors of this report. Address correspondence to Prof. C. Cooper, MRC Lifecourse Epidemiology Unit (University of Southampton), Southampton General Hospital, Southampton, SO16 6YD, UK. E-mail: cc@mrc.soton.ac.uk. Accepted for publication September 11, 2015.
Souhil Zaim
From the MRC Lifecourse Epidemiology Unit, University of Southampton, Southampton, UK; Department of Public Health and Health Economics, University of Liege, Liege, Belgium; Innovative Therapeutic Pole of Rheumatology, Servier, Surenes, France; INSERM UMR 1033, Service de Rhumatolgie et Pathologie Osseuse, Hôpital Edouard Herriot, Université de Lyon, Lyon, France; Quantitative Imaging Center, Department of Radiology, Boston University School of Medicine, Boston, Massachusetts, USA; Department of Radiology, University of Erlangen-Nuremburg, Erlangen, Germany; Synarc, San Francisco, California, USA; Department of Public Health and Health Economics, University of Liege; NIHR Biomedical Research Centre, University of Southampton and University Hospital Southampton NHS Foundation Trust, Southampton General Hospital; and NIHR Musculoskeletal Biomedical Research Unit, Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences, University of Oxford, Oxford, UK. Supported by the Medical Research Council of Great Britain; Arthritis Research UK; and the International Osteoporosis Foundation; and by the National Institute of Health Research Nutrition Biomedical Research Centre, University of Southampton and the National Institute of Health Research Musculoskeletal Biomedical Research Unit, University of Oxford. Dr. Edwards is supported by an Arthritis Research UK Clinical PhD Studentship. M.H. Edwards, MD, PhD; C. Parsons, MSc, MRC Lifecourse Epidemiology Unit, University of Southampton; O. Bruyère, PhD, Department of Public Health and Health Economics, University of Liege; F. Petit Dop, PhD, Innovative Therapeutic Pole of Rheumatology; R. Chapurlat, MD, PhD, INSERM UMR 1033, Service de Rhumatolgie et Pathologie Osseuse, Hôpital Edouard Herriot, Université de Lyon; F.W. Roemer, MD, Quantitative Imaging Center, Department of Radiology, Boston University School of Medicine; Department of Radiology, University of Erlangen-Nuremburg; A. Guermazi, MD, PhD, Quantitative Imaging Center, Department of Radiology, Boston University School of Medicine; S. Zaim, MD, Synarc; H. Genant, MD, Synarc; J-Y. Reginster, MD, PhD, Department of Public Health and Health Economics, University of Liege; E.M. Dennison, MD, PhD, MRC Lifecourse Epidemiology Unit, University of Southampton; Victoria University; C. Cooper, FMedSci, MRC Lifecourse Epidemiology Unit, University of Southampton; NIHR Biomedical Research Centre, University of Southampton and University Hospital Southampton NHS Foundation Trust, Southampton General Hospital; NIHR Musculoskeletal Biomedical Research Unit, Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences, University of Oxford, Oxford, UK. C. Parsons and Dr. Edwards are joint first authors of this report. Address correspondence to Prof. C. Cooper, MRC Lifecourse Epidemiology Unit (University of Southampton), Southampton General Hospital, Southampton, SO16 6YD, UK. E-mail: cc@mrc.soton.ac.uk. Accepted for publication September 11, 2015.
Harry Genant
From the MRC Lifecourse Epidemiology Unit, University of Southampton, Southampton, UK; Department of Public Health and Health Economics, University of Liege, Liege, Belgium; Innovative Therapeutic Pole of Rheumatology, Servier, Surenes, France; INSERM UMR 1033, Service de Rhumatolgie et Pathologie Osseuse, Hôpital Edouard Herriot, Université de Lyon, Lyon, France; Quantitative Imaging Center, Department of Radiology, Boston University School of Medicine, Boston, Massachusetts, USA; Department of Radiology, University of Erlangen-Nuremburg, Erlangen, Germany; Synarc, San Francisco, California, USA; Department of Public Health and Health Economics, University of Liege; NIHR Biomedical Research Centre, University of Southampton and University Hospital Southampton NHS Foundation Trust, Southampton General Hospital; and NIHR Musculoskeletal Biomedical Research Unit, Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences, University of Oxford, Oxford, UK. Supported by the Medical Research Council of Great Britain; Arthritis Research UK; and the International Osteoporosis Foundation; and by the National Institute of Health Research Nutrition Biomedical Research Centre, University of Southampton and the National Institute of Health Research Musculoskeletal Biomedical Research Unit, University of Oxford. Dr. Edwards is supported by an Arthritis Research UK Clinical PhD Studentship. M.H. Edwards, MD, PhD; C. Parsons, MSc, MRC Lifecourse Epidemiology Unit, University of Southampton; O. Bruyère, PhD, Department of Public Health and Health Economics, University of Liege; F. Petit Dop, PhD, Innovative Therapeutic Pole of Rheumatology; R. Chapurlat, MD, PhD, INSERM UMR 1033, Service de Rhumatolgie et Pathologie Osseuse, Hôpital Edouard Herriot, Université de Lyon; F.W. Roemer, MD, Quantitative Imaging Center, Department of Radiology, Boston University School of Medicine; Department of Radiology, University of Erlangen-Nuremburg; A. Guermazi, MD, PhD, Quantitative Imaging Center, Department of Radiology, Boston University School of Medicine; S. Zaim, MD, Synarc; H. Genant, MD, Synarc; J-Y. Reginster, MD, PhD, Department of Public Health and Health Economics, University of Liege; E.M. Dennison, MD, PhD, MRC Lifecourse Epidemiology Unit, University of Southampton; Victoria University; C. Cooper, FMedSci, MRC Lifecourse Epidemiology Unit, University of Southampton; NIHR Biomedical Research Centre, University of Southampton and University Hospital Southampton NHS Foundation Trust, Southampton General Hospital; NIHR Musculoskeletal Biomedical Research Unit, Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences, University of Oxford, Oxford, UK. C. Parsons and Dr. Edwards are joint first authors of this report. Address correspondence to Prof. C. Cooper, MRC Lifecourse Epidemiology Unit (University of Southampton), Southampton General Hospital, Southampton, SO16 6YD, UK. E-mail: cc@mrc.soton.ac.uk. Accepted for publication September 11, 2015.
Jean-Yves Reginster
From the MRC Lifecourse Epidemiology Unit, University of Southampton, Southampton, UK; Department of Public Health and Health Economics, University of Liege, Liege, Belgium; Innovative Therapeutic Pole of Rheumatology, Servier, Surenes, France; INSERM UMR 1033, Service de Rhumatolgie et Pathologie Osseuse, Hôpital Edouard Herriot, Université de Lyon, Lyon, France; Quantitative Imaging Center, Department of Radiology, Boston University School of Medicine, Boston, Massachusetts, USA; Department of Radiology, University of Erlangen-Nuremburg, Erlangen, Germany; Synarc, San Francisco, California, USA; Department of Public Health and Health Economics, University of Liege; NIHR Biomedical Research Centre, University of Southampton and University Hospital Southampton NHS Foundation Trust, Southampton General Hospital; and NIHR Musculoskeletal Biomedical Research Unit, Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences, University of Oxford, Oxford, UK. Supported by the Medical Research Council of Great Britain; Arthritis Research UK; and the International Osteoporosis Foundation; and by the National Institute of Health Research Nutrition Biomedical Research Centre, University of Southampton and the National Institute of Health Research Musculoskeletal Biomedical Research Unit, University of Oxford. Dr. Edwards is supported by an Arthritis Research UK Clinical PhD Studentship. M.H. Edwards, MD, PhD; C. Parsons, MSc, MRC Lifecourse Epidemiology Unit, University of Southampton; O. Bruyère, PhD, Department of Public Health and Health Economics, University of Liege; F. Petit Dop, PhD, Innovative Therapeutic Pole of Rheumatology; R. Chapurlat, MD, PhD, INSERM UMR 1033, Service de Rhumatolgie et Pathologie Osseuse, Hôpital Edouard Herriot, Université de Lyon; F.W. Roemer, MD, Quantitative Imaging Center, Department of Radiology, Boston University School of Medicine; Department of Radiology, University of Erlangen-Nuremburg; A. Guermazi, MD, PhD, Quantitative Imaging Center, Department of Radiology, Boston University School of Medicine; S. Zaim, MD, Synarc; H. Genant, MD, Synarc; J-Y. Reginster, MD, PhD, Department of Public Health and Health Economics, University of Liege; E.M. Dennison, MD, PhD, MRC Lifecourse Epidemiology Unit, University of Southampton; Victoria University; C. Cooper, FMedSci, MRC Lifecourse Epidemiology Unit, University of Southampton; NIHR Biomedical Research Centre, University of Southampton and University Hospital Southampton NHS Foundation Trust, Southampton General Hospital; NIHR Musculoskeletal Biomedical Research Unit, Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences, University of Oxford, Oxford, UK. C. Parsons and Dr. Edwards are joint first authors of this report. Address correspondence to Prof. C. Cooper, MRC Lifecourse Epidemiology Unit (University of Southampton), Southampton General Hospital, Southampton, SO16 6YD, UK. E-mail: cc@mrc.soton.ac.uk. Accepted for publication September 11, 2015.
Elaine M. Dennison
From the MRC Lifecourse Epidemiology Unit, University of Southampton, Southampton, UK; Department of Public Health and Health Economics, University of Liege, Liege, Belgium; Innovative Therapeutic Pole of Rheumatology, Servier, Surenes, France; INSERM UMR 1033, Service de Rhumatolgie et Pathologie Osseuse, Hôpital Edouard Herriot, Université de Lyon, Lyon, France; Quantitative Imaging Center, Department of Radiology, Boston University School of Medicine, Boston, Massachusetts, USA; Department of Radiology, University of Erlangen-Nuremburg, Erlangen, Germany; Synarc, San Francisco, California, USA; Department of Public Health and Health Economics, University of Liege; NIHR Biomedical Research Centre, University of Southampton and University Hospital Southampton NHS Foundation Trust, Southampton General Hospital; and NIHR Musculoskeletal Biomedical Research Unit, Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences, University of Oxford, Oxford, UK. Supported by the Medical Research Council of Great Britain; Arthritis Research UK; and the International Osteoporosis Foundation; and by the National Institute of Health Research Nutrition Biomedical Research Centre, University of Southampton and the National Institute of Health Research Musculoskeletal Biomedical Research Unit, University of Oxford. Dr. Edwards is supported by an Arthritis Research UK Clinical PhD Studentship. M.H. Edwards, MD, PhD; C. Parsons, MSc, MRC Lifecourse Epidemiology Unit, University of Southampton; O. Bruyère, PhD, Department of Public Health and Health Economics, University of Liege; F. Petit Dop, PhD, Innovative Therapeutic Pole of Rheumatology; R. Chapurlat, MD, PhD, INSERM UMR 1033, Service de Rhumatolgie et Pathologie Osseuse, Hôpital Edouard Herriot, Université de Lyon; F.W. Roemer, MD, Quantitative Imaging Center, Department of Radiology, Boston University School of Medicine; Department of Radiology, University of Erlangen-Nuremburg; A. Guermazi, MD, PhD, Quantitative Imaging Center, Department of Radiology, Boston University School of Medicine; S. Zaim, MD, Synarc; H. Genant, MD, Synarc; J-Y. Reginster, MD, PhD, Department of Public Health and Health Economics, University of Liege; E.M. Dennison, MD, PhD, MRC Lifecourse Epidemiology Unit, University of Southampton; Victoria University; C. Cooper, FMedSci, MRC Lifecourse Epidemiology Unit, University of Southampton; NIHR Biomedical Research Centre, University of Southampton and University Hospital Southampton NHS Foundation Trust, Southampton General Hospital; NIHR Musculoskeletal Biomedical Research Unit, Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences, University of Oxford, Oxford, UK. C. Parsons and Dr. Edwards are joint first authors of this report. Address correspondence to Prof. C. Cooper, MRC Lifecourse Epidemiology Unit (University of Southampton), Southampton General Hospital, Southampton, SO16 6YD, UK. E-mail: cc@mrc.soton.ac.uk. Accepted for publication September 11, 2015.
Cyrus Cooper
From the MRC Lifecourse Epidemiology Unit, University of Southampton, Southampton, UK; Department of Public Health and Health Economics, University of Liege, Liege, Belgium; Innovative Therapeutic Pole of Rheumatology, Servier, Surenes, France; INSERM UMR 1033, Service de Rhumatolgie et Pathologie Osseuse, Hôpital Edouard Herriot, Université de Lyon, Lyon, France; Quantitative Imaging Center, Department of Radiology, Boston University School of Medicine, Boston, Massachusetts, USA; Department of Radiology, University of Erlangen-Nuremburg, Erlangen, Germany; Synarc, San Francisco, California, USA; Department of Public Health and Health Economics, University of Liege; NIHR Biomedical Research Centre, University of Southampton and University Hospital Southampton NHS Foundation Trust, Southampton General Hospital; and NIHR Musculoskeletal Biomedical Research Unit, Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences, University of Oxford, Oxford, UK. Supported by the Medical Research Council of Great Britain; Arthritis Research UK; and the International Osteoporosis Foundation; and by the National Institute of Health Research Nutrition Biomedical Research Centre, University of Southampton and the National Institute of Health Research Musculoskeletal Biomedical Research Unit, University of Oxford. Dr. Edwards is supported by an Arthritis Research UK Clinical PhD Studentship. M.H. Edwards, MD, PhD; C. Parsons, MSc, MRC Lifecourse Epidemiology Unit, University of Southampton; O. Bruyère, PhD, Department of Public Health and Health Economics, University of Liege; F. Petit Dop, PhD, Innovative Therapeutic Pole of Rheumatology; R. Chapurlat, MD, PhD, INSERM UMR 1033, Service de Rhumatolgie et Pathologie Osseuse, Hôpital Edouard Herriot, Université de Lyon; F.W. Roemer, MD, Quantitative Imaging Center, Department of Radiology, Boston University School of Medicine; Department of Radiology, University of Erlangen-Nuremburg; A. Guermazi, MD, PhD, Quantitative Imaging Center, Department of Radiology, Boston University School of Medicine; S. Zaim, MD, Synarc; H. Genant, MD, Synarc; J-Y. Reginster, MD, PhD, Department of Public Health and Health Economics, University of Liege; E.M. Dennison, MD, PhD, MRC Lifecourse Epidemiology Unit, University of Southampton; Victoria University; C. Cooper, FMedSci, MRC Lifecourse Epidemiology Unit, University of Southampton; NIHR Biomedical Research Centre, University of Southampton and University Hospital Southampton NHS Foundation Trust, Southampton General Hospital; NIHR Musculoskeletal Biomedical Research Unit, Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences, University of Oxford, Oxford, UK. C. Parsons and Dr. Edwards are joint first authors of this report. Address correspondence to Prof. C. Cooper, MRC Lifecourse Epidemiology Unit (University of Southampton), Southampton General Hospital, Southampton, SO16 6YD, UK. E-mail: cc@mrc.soton.ac.uk. Accepted for publication September 11, 2015.
From the MRC Lifecourse Epidemiology Unit, University of Southampton, Southampton, UK; Department of Public Health and Health Economics, University of Liege, Liege, Belgium; Innovative Therapeutic Pole of Rheumatology, Servier, Surenes, France; INSERM UMR 1033, Service de Rhumatolgie et Pathologie Osseuse, Hôpital Edouard Herriot, Université de Lyon, Lyon, France; Quantitative Imaging Center, Department of Radiology, Boston University School of Medicine, Boston, Massachusetts, USA; Department of Radiology, University of Erlangen-Nuremburg, Erlangen, Germany; Synarc, San Francisco, California, USA; Department of Public Health and Health Economics, University of Liege; NIHR Biomedical Research Centre, University of Southampton and University Hospital Southampton NHS Foundation Trust, Southampton General Hospital; and NIHR Musculoskeletal Biomedical Research Unit, Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences, University of Oxford, Oxford, UK. Supported by the Medical Research Council of Great Britain; Arthritis Research UK; and the International Osteoporosis Foundation; and by the National Institute of Health Research Nutrition Biomedical Research Centre, University of Southampton and the National Institute of Health Research Musculoskeletal Biomedical Research Unit, University of Oxford. Dr. Edwards is supported by an Arthritis Research UK Clinical PhD Studentship. M.H. Edwards, MD, PhD; C. Parsons, MSc, MRC Lifecourse Epidemiology Unit, University of Southampton; O. Bruyère, PhD, Department of Public Health and Health Economics, University of Liege; F. Petit Dop, PhD, Innovative Therapeutic Pole of Rheumatology; R. Chapurlat, MD, PhD, INSERM UMR 1033, Service de Rhumatolgie et Pathologie Osseuse, Hôpital Edouard Herriot, Université de Lyon; F.W. Roemer, MD, Quantitative Imaging Center, Department of Radiology, Boston University School of Medicine; Department of Radiology, University of Erlangen-Nuremburg; A. Guermazi, MD, PhD, Quantitative Imaging Center, Department of Radiology, Boston University School of Medicine; S. Zaim, MD, Synarc; H. Genant, MD, Synarc; J-Y. Reginster, MD, PhD, Department of Public Health and Health Economics, University of Liege; E.M. Dennison, MD, PhD, MRC Lifecourse Epidemiology Unit, University of Southampton; Victoria University; C. Cooper, FMedSci, MRC Lifecourse Epidemiology Unit, University of Southampton; NIHR Biomedical Research Centre, University of Southampton and University Hospital Southampton NHS Foundation Trust, Southampton General Hospital; NIHR Musculoskeletal Biomedical Research Unit, Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences, University of Oxford, Oxford, UK. C. Parsons and Dr. Edwards are joint first authors of this report. Address correspondence to Prof. C. Cooper, MRC Lifecourse Epidemiology Unit (University of Southampton), Southampton General Hospital, Southampton, SO16 6YD, UK. E-mail: cc@mrc.soton.ac.uk. Accepted for publication September 11, 2015.
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In this issue
The Journal of Rheumatology
Vol. 51, Issue 4
1 Apr 2024
High Kellgren-Lawrence Grade and Bone Marrow Lesions Predict Worsening Rates of Radiographic Joint Space Narrowing; The SEKOIA Study
Mark H. Edwards, Camille Parsons, Olivier Bruyère, Forence Petit Dop, Roland Chapurlat, Frank W. Roemer, Ali Guermazi, Souhil Zaim, Harry Genant, Jean-Yves Reginster, Elaine M. Dennison, Cyrus Cooper, and the SEKOIA Study Group
The Journal of Rheumatology Jan 2016, jrheum.150053; DOI: 10.3899/jrheum.150053
High Kellgren-Lawrence Grade and Bone Marrow Lesions Predict Worsening Rates of Radiographic Joint Space Narrowing; The SEKOIA Study
Mark H. Edwards, Camille Parsons, Olivier Bruyère, Forence Petit Dop, Roland Chapurlat, Frank W. Roemer, Ali Guermazi, Souhil Zaim, Harry Genant, Jean-Yves Reginster, Elaine M. Dennison, Cyrus Cooper, and the SEKOIA Study Group
The Journal of Rheumatology Jan 2016, jrheum.150053; DOI: 10.3899/jrheum.150053