Research ArticleArticle
SMAD3 Is Upregulated in Human Osteoarthritic Cartilage Independent of the Promoter DNA Methylation
Erfan Aref-Eshghi, Ming Liu, Seyd Babak Razavi-Lopez, Kensuke Hirasawa, Patricia E. Harper, Glynn Martin, Andrew Furey, Roger Green, Guang Sun, Proton Rahman and Guangju Zhai
The Journal of Rheumatology December 2015, jrheum.150609; DOI: https://doi.org/10.3899/jrheum.150609
Erfan Aref-Eshghi
From the Discipline of Genetics, Division of Biomedical Science, Division of Orthopedics, Discipline of Medicine, Faculty of Medicine, Memorial University of Newfoundland, St. John’s, Newfoundland, Canada; and the Department of Twin Research and Genetic Epidemiology, King’s College London, London, UK. Supported by the Canadian Institutes of Health Research (CIHR), Newfoundland and Labrador RDC, and Memorial University of Newfoundland. E. Aref-Eshghi, MD, PhD Candidate; M. Liu, MSc, Research Assistant, Discipline of Genetics; S. Razavi-Lopez, BSc, Research Assistant; K. Hirasawa, PhD, Professor, Division of Biomedical Science; P.E. Harper, BSc, Master’s Student, Discipline of Genetics; G. Martin, MD, Orthopedic Surgeon; A. Furey, MD, Associate Professor of Surgery, Division of Orthopedics; R. Green*, PhD, Honorary Research Professor, Discipline of Genetics; G. Sun, PhD, Professor; P. Rahman, MD, Professor of Medicine (Rheumatology), Discipline of Medicine, Faculty of Medicine, Memorial University of Newfoundland, St. John’s, Newfoundland, Canada; G. Zhai, PhD, Associate Professor, Discipline of Genetics, Faculty of Medicine, Memorial University of Newfoundland; Department of Twin Research and Genetic Epidemiology, King’s College London, London, UK. *Prof. Green is deceased. Address correspondence to Dr. G. Zhai, Discipline of Genetics, Faculty of Medicine, Memorial University of Newfoundland, St. John’s, NL, Canada A1B 3V6. E-mail: guangju.zhai@med.mun.ca. Accepted for publication September 1, 2015.
Ming Liu
From the Discipline of Genetics, Division of Biomedical Science, Division of Orthopedics, Discipline of Medicine, Faculty of Medicine, Memorial University of Newfoundland, St. John’s, Newfoundland, Canada; and the Department of Twin Research and Genetic Epidemiology, King’s College London, London, UK. Supported by the Canadian Institutes of Health Research (CIHR), Newfoundland and Labrador RDC, and Memorial University of Newfoundland. E. Aref-Eshghi, MD, PhD Candidate; M. Liu, MSc, Research Assistant, Discipline of Genetics; S. Razavi-Lopez, BSc, Research Assistant; K. Hirasawa, PhD, Professor, Division of Biomedical Science; P.E. Harper, BSc, Master’s Student, Discipline of Genetics; G. Martin, MD, Orthopedic Surgeon; A. Furey, MD, Associate Professor of Surgery, Division of Orthopedics; R. Green*, PhD, Honorary Research Professor, Discipline of Genetics; G. Sun, PhD, Professor; P. Rahman, MD, Professor of Medicine (Rheumatology), Discipline of Medicine, Faculty of Medicine, Memorial University of Newfoundland, St. John’s, Newfoundland, Canada; G. Zhai, PhD, Associate Professor, Discipline of Genetics, Faculty of Medicine, Memorial University of Newfoundland; Department of Twin Research and Genetic Epidemiology, King’s College London, London, UK. *Prof. Green is deceased. Address correspondence to Dr. G. Zhai, Discipline of Genetics, Faculty of Medicine, Memorial University of Newfoundland, St. John’s, NL, Canada A1B 3V6. E-mail: guangju.zhai@med.mun.ca. Accepted for publication September 1, 2015.
Seyd Babak Razavi-Lopez
From the Discipline of Genetics, Division of Biomedical Science, Division of Orthopedics, Discipline of Medicine, Faculty of Medicine, Memorial University of Newfoundland, St. John’s, Newfoundland, Canada; and the Department of Twin Research and Genetic Epidemiology, King’s College London, London, UK. Supported by the Canadian Institutes of Health Research (CIHR), Newfoundland and Labrador RDC, and Memorial University of Newfoundland. E. Aref-Eshghi, MD, PhD Candidate; M. Liu, MSc, Research Assistant, Discipline of Genetics; S. Razavi-Lopez, BSc, Research Assistant; K. Hirasawa, PhD, Professor, Division of Biomedical Science; P.E. Harper, BSc, Master’s Student, Discipline of Genetics; G. Martin, MD, Orthopedic Surgeon; A. Furey, MD, Associate Professor of Surgery, Division of Orthopedics; R. Green*, PhD, Honorary Research Professor, Discipline of Genetics; G. Sun, PhD, Professor; P. Rahman, MD, Professor of Medicine (Rheumatology), Discipline of Medicine, Faculty of Medicine, Memorial University of Newfoundland, St. John’s, Newfoundland, Canada; G. Zhai, PhD, Associate Professor, Discipline of Genetics, Faculty of Medicine, Memorial University of Newfoundland; Department of Twin Research and Genetic Epidemiology, King’s College London, London, UK. *Prof. Green is deceased. Address correspondence to Dr. G. Zhai, Discipline of Genetics, Faculty of Medicine, Memorial University of Newfoundland, St. John’s, NL, Canada A1B 3V6. E-mail: guangju.zhai@med.mun.ca. Accepted for publication September 1, 2015.
Kensuke Hirasawa
From the Discipline of Genetics, Division of Biomedical Science, Division of Orthopedics, Discipline of Medicine, Faculty of Medicine, Memorial University of Newfoundland, St. John’s, Newfoundland, Canada; and the Department of Twin Research and Genetic Epidemiology, King’s College London, London, UK. Supported by the Canadian Institutes of Health Research (CIHR), Newfoundland and Labrador RDC, and Memorial University of Newfoundland. E. Aref-Eshghi, MD, PhD Candidate; M. Liu, MSc, Research Assistant, Discipline of Genetics; S. Razavi-Lopez, BSc, Research Assistant; K. Hirasawa, PhD, Professor, Division of Biomedical Science; P.E. Harper, BSc, Master’s Student, Discipline of Genetics; G. Martin, MD, Orthopedic Surgeon; A. Furey, MD, Associate Professor of Surgery, Division of Orthopedics; R. Green*, PhD, Honorary Research Professor, Discipline of Genetics; G. Sun, PhD, Professor; P. Rahman, MD, Professor of Medicine (Rheumatology), Discipline of Medicine, Faculty of Medicine, Memorial University of Newfoundland, St. John’s, Newfoundland, Canada; G. Zhai, PhD, Associate Professor, Discipline of Genetics, Faculty of Medicine, Memorial University of Newfoundland; Department of Twin Research and Genetic Epidemiology, King’s College London, London, UK. *Prof. Green is deceased. Address correspondence to Dr. G. Zhai, Discipline of Genetics, Faculty of Medicine, Memorial University of Newfoundland, St. John’s, NL, Canada A1B 3V6. E-mail: guangju.zhai@med.mun.ca. Accepted for publication September 1, 2015.
Patricia E. Harper
From the Discipline of Genetics, Division of Biomedical Science, Division of Orthopedics, Discipline of Medicine, Faculty of Medicine, Memorial University of Newfoundland, St. John’s, Newfoundland, Canada; and the Department of Twin Research and Genetic Epidemiology, King’s College London, London, UK. Supported by the Canadian Institutes of Health Research (CIHR), Newfoundland and Labrador RDC, and Memorial University of Newfoundland. E. Aref-Eshghi, MD, PhD Candidate; M. Liu, MSc, Research Assistant, Discipline of Genetics; S. Razavi-Lopez, BSc, Research Assistant; K. Hirasawa, PhD, Professor, Division of Biomedical Science; P.E. Harper, BSc, Master’s Student, Discipline of Genetics; G. Martin, MD, Orthopedic Surgeon; A. Furey, MD, Associate Professor of Surgery, Division of Orthopedics; R. Green*, PhD, Honorary Research Professor, Discipline of Genetics; G. Sun, PhD, Professor; P. Rahman, MD, Professor of Medicine (Rheumatology), Discipline of Medicine, Faculty of Medicine, Memorial University of Newfoundland, St. John’s, Newfoundland, Canada; G. Zhai, PhD, Associate Professor, Discipline of Genetics, Faculty of Medicine, Memorial University of Newfoundland; Department of Twin Research and Genetic Epidemiology, King’s College London, London, UK. *Prof. Green is deceased. Address correspondence to Dr. G. Zhai, Discipline of Genetics, Faculty of Medicine, Memorial University of Newfoundland, St. John’s, NL, Canada A1B 3V6. E-mail: guangju.zhai@med.mun.ca. Accepted for publication September 1, 2015.
Glynn Martin
From the Discipline of Genetics, Division of Biomedical Science, Division of Orthopedics, Discipline of Medicine, Faculty of Medicine, Memorial University of Newfoundland, St. John’s, Newfoundland, Canada; and the Department of Twin Research and Genetic Epidemiology, King’s College London, London, UK. Supported by the Canadian Institutes of Health Research (CIHR), Newfoundland and Labrador RDC, and Memorial University of Newfoundland. E. Aref-Eshghi, MD, PhD Candidate; M. Liu, MSc, Research Assistant, Discipline of Genetics; S. Razavi-Lopez, BSc, Research Assistant; K. Hirasawa, PhD, Professor, Division of Biomedical Science; P.E. Harper, BSc, Master’s Student, Discipline of Genetics; G. Martin, MD, Orthopedic Surgeon; A. Furey, MD, Associate Professor of Surgery, Division of Orthopedics; R. Green*, PhD, Honorary Research Professor, Discipline of Genetics; G. Sun, PhD, Professor; P. Rahman, MD, Professor of Medicine (Rheumatology), Discipline of Medicine, Faculty of Medicine, Memorial University of Newfoundland, St. John’s, Newfoundland, Canada; G. Zhai, PhD, Associate Professor, Discipline of Genetics, Faculty of Medicine, Memorial University of Newfoundland; Department of Twin Research and Genetic Epidemiology, King’s College London, London, UK. *Prof. Green is deceased. Address correspondence to Dr. G. Zhai, Discipline of Genetics, Faculty of Medicine, Memorial University of Newfoundland, St. John’s, NL, Canada A1B 3V6. E-mail: guangju.zhai@med.mun.ca. Accepted for publication September 1, 2015.
Andrew Furey
From the Discipline of Genetics, Division of Biomedical Science, Division of Orthopedics, Discipline of Medicine, Faculty of Medicine, Memorial University of Newfoundland, St. John’s, Newfoundland, Canada; and the Department of Twin Research and Genetic Epidemiology, King’s College London, London, UK. Supported by the Canadian Institutes of Health Research (CIHR), Newfoundland and Labrador RDC, and Memorial University of Newfoundland. E. Aref-Eshghi, MD, PhD Candidate; M. Liu, MSc, Research Assistant, Discipline of Genetics; S. Razavi-Lopez, BSc, Research Assistant; K. Hirasawa, PhD, Professor, Division of Biomedical Science; P.E. Harper, BSc, Master’s Student, Discipline of Genetics; G. Martin, MD, Orthopedic Surgeon; A. Furey, MD, Associate Professor of Surgery, Division of Orthopedics; R. Green*, PhD, Honorary Research Professor, Discipline of Genetics; G. Sun, PhD, Professor; P. Rahman, MD, Professor of Medicine (Rheumatology), Discipline of Medicine, Faculty of Medicine, Memorial University of Newfoundland, St. John’s, Newfoundland, Canada; G. Zhai, PhD, Associate Professor, Discipline of Genetics, Faculty of Medicine, Memorial University of Newfoundland; Department of Twin Research and Genetic Epidemiology, King’s College London, London, UK. *Prof. Green is deceased. Address correspondence to Dr. G. Zhai, Discipline of Genetics, Faculty of Medicine, Memorial University of Newfoundland, St. John’s, NL, Canada A1B 3V6. E-mail: guangju.zhai@med.mun.ca. Accepted for publication September 1, 2015.
Roger Green
From the Discipline of Genetics, Division of Biomedical Science, Division of Orthopedics, Discipline of Medicine, Faculty of Medicine, Memorial University of Newfoundland, St. John’s, Newfoundland, Canada; and the Department of Twin Research and Genetic Epidemiology, King’s College London, London, UK. Supported by the Canadian Institutes of Health Research (CIHR), Newfoundland and Labrador RDC, and Memorial University of Newfoundland. E. Aref-Eshghi, MD, PhD Candidate; M. Liu, MSc, Research Assistant, Discipline of Genetics; S. Razavi-Lopez, BSc, Research Assistant; K. Hirasawa, PhD, Professor, Division of Biomedical Science; P.E. Harper, BSc, Master’s Student, Discipline of Genetics; G. Martin, MD, Orthopedic Surgeon; A. Furey, MD, Associate Professor of Surgery, Division of Orthopedics; R. Green*, PhD, Honorary Research Professor, Discipline of Genetics; G. Sun, PhD, Professor; P. Rahman, MD, Professor of Medicine (Rheumatology), Discipline of Medicine, Faculty of Medicine, Memorial University of Newfoundland, St. John’s, Newfoundland, Canada; G. Zhai, PhD, Associate Professor, Discipline of Genetics, Faculty of Medicine, Memorial University of Newfoundland; Department of Twin Research and Genetic Epidemiology, King’s College London, London, UK. *Prof. Green is deceased. Address correspondence to Dr. G. Zhai, Discipline of Genetics, Faculty of Medicine, Memorial University of Newfoundland, St. John’s, NL, Canada A1B 3V6. E-mail: guangju.zhai@med.mun.ca. Accepted for publication September 1, 2015.
Guang Sun
From the Discipline of Genetics, Division of Biomedical Science, Division of Orthopedics, Discipline of Medicine, Faculty of Medicine, Memorial University of Newfoundland, St. John’s, Newfoundland, Canada; and the Department of Twin Research and Genetic Epidemiology, King’s College London, London, UK. Supported by the Canadian Institutes of Health Research (CIHR), Newfoundland and Labrador RDC, and Memorial University of Newfoundland. E. Aref-Eshghi, MD, PhD Candidate; M. Liu, MSc, Research Assistant, Discipline of Genetics; S. Razavi-Lopez, BSc, Research Assistant; K. Hirasawa, PhD, Professor, Division of Biomedical Science; P.E. Harper, BSc, Master’s Student, Discipline of Genetics; G. Martin, MD, Orthopedic Surgeon; A. Furey, MD, Associate Professor of Surgery, Division of Orthopedics; R. Green*, PhD, Honorary Research Professor, Discipline of Genetics; G. Sun, PhD, Professor; P. Rahman, MD, Professor of Medicine (Rheumatology), Discipline of Medicine, Faculty of Medicine, Memorial University of Newfoundland, St. John’s, Newfoundland, Canada; G. Zhai, PhD, Associate Professor, Discipline of Genetics, Faculty of Medicine, Memorial University of Newfoundland; Department of Twin Research and Genetic Epidemiology, King’s College London, London, UK. *Prof. Green is deceased. Address correspondence to Dr. G. Zhai, Discipline of Genetics, Faculty of Medicine, Memorial University of Newfoundland, St. John’s, NL, Canada A1B 3V6. E-mail: guangju.zhai@med.mun.ca. Accepted for publication September 1, 2015.
Proton Rahman
From the Discipline of Genetics, Division of Biomedical Science, Division of Orthopedics, Discipline of Medicine, Faculty of Medicine, Memorial University of Newfoundland, St. John’s, Newfoundland, Canada; and the Department of Twin Research and Genetic Epidemiology, King’s College London, London, UK. Supported by the Canadian Institutes of Health Research (CIHR), Newfoundland and Labrador RDC, and Memorial University of Newfoundland. E. Aref-Eshghi, MD, PhD Candidate; M. Liu, MSc, Research Assistant, Discipline of Genetics; S. Razavi-Lopez, BSc, Research Assistant; K. Hirasawa, PhD, Professor, Division of Biomedical Science; P.E. Harper, BSc, Master’s Student, Discipline of Genetics; G. Martin, MD, Orthopedic Surgeon; A. Furey, MD, Associate Professor of Surgery, Division of Orthopedics; R. Green*, PhD, Honorary Research Professor, Discipline of Genetics; G. Sun, PhD, Professor; P. Rahman, MD, Professor of Medicine (Rheumatology), Discipline of Medicine, Faculty of Medicine, Memorial University of Newfoundland, St. John’s, Newfoundland, Canada; G. Zhai, PhD, Associate Professor, Discipline of Genetics, Faculty of Medicine, Memorial University of Newfoundland; Department of Twin Research and Genetic Epidemiology, King’s College London, London, UK. *Prof. Green is deceased. Address correspondence to Dr. G. Zhai, Discipline of Genetics, Faculty of Medicine, Memorial University of Newfoundland, St. John’s, NL, Canada A1B 3V6. E-mail: guangju.zhai@med.mun.ca. Accepted for publication September 1, 2015.
Guangju Zhai
From the Discipline of Genetics, Division of Biomedical Science, Division of Orthopedics, Discipline of Medicine, Faculty of Medicine, Memorial University of Newfoundland, St. John’s, Newfoundland, Canada; and the Department of Twin Research and Genetic Epidemiology, King’s College London, London, UK. Supported by the Canadian Institutes of Health Research (CIHR), Newfoundland and Labrador RDC, and Memorial University of Newfoundland. E. Aref-Eshghi, MD, PhD Candidate; M. Liu, MSc, Research Assistant, Discipline of Genetics; S. Razavi-Lopez, BSc, Research Assistant; K. Hirasawa, PhD, Professor, Division of Biomedical Science; P.E. Harper, BSc, Master’s Student, Discipline of Genetics; G. Martin, MD, Orthopedic Surgeon; A. Furey, MD, Associate Professor of Surgery, Division of Orthopedics; R. Green*, PhD, Honorary Research Professor, Discipline of Genetics; G. Sun, PhD, Professor; P. Rahman, MD, Professor of Medicine (Rheumatology), Discipline of Medicine, Faculty of Medicine, Memorial University of Newfoundland, St. John’s, Newfoundland, Canada; G. Zhai, PhD, Associate Professor, Discipline of Genetics, Faculty of Medicine, Memorial University of Newfoundland; Department of Twin Research and Genetic Epidemiology, King’s College London, London, UK. *Prof. Green is deceased. Address correspondence to Dr. G. Zhai, Discipline of Genetics, Faculty of Medicine, Memorial University of Newfoundland, St. John’s, NL, Canada A1B 3V6. E-mail: guangju.zhai@med.mun.ca. Accepted for publication September 1, 2015.
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In this issue
The Journal of Rheumatology
Vol. 51, Issue 3
1 Mar 2024
SMAD3 Is Upregulated in Human Osteoarthritic Cartilage Independent of the Promoter DNA Methylation
Erfan Aref-Eshghi, Ming Liu, Seyd Babak Razavi-Lopez, Kensuke Hirasawa, Patricia E. Harper, Glynn Martin, Andrew Furey, Roger Green, Guang Sun, Proton Rahman, Guangju Zhai
The Journal of Rheumatology Dec 2015, jrheum.150609; DOI: 10.3899/jrheum.150609
SMAD3 Is Upregulated in Human Osteoarthritic Cartilage Independent of the Promoter DNA Methylation
Erfan Aref-Eshghi, Ming Liu, Seyd Babak Razavi-Lopez, Kensuke Hirasawa, Patricia E. Harper, Glynn Martin, Andrew Furey, Roger Green, Guang Sun, Proton Rahman, Guangju Zhai
The Journal of Rheumatology Dec 2015, jrheum.150609; DOI: 10.3899/jrheum.150609