Research ArticleArticle
Effect of Milnacipran on Pain in Patients with Rheumatoid Arthritis with Widespread Pain: A Randomized Blinded Crossover Trial
Yvonne C. Lee, Elena Massarotti, Robert R. Edwards, Bing Lu, ChihChin Liu, Yuanyu Lo, Alyssa Wohlfahrt, Nancy D. Kim, Daniel J. Clauw and Daniel H. Solomon
The Journal of Rheumatology December 2015, jrheum.150550; DOI: https://doi.org/10.3899/jrheum.150550
Yvonne C. Lee
From the Division of Rheumatology, Immunology and Allergy, and Department of Anesthesiology, Brigham and Women’s Hospital; Division of Rheumatology, Immunology and Allergy, Massachusetts General Hospital, Boston, Massachusetts; Department of Anesthesiology, University of Michigan Medical Center, Ann Arbor, Michigan, USA. Funded by a grant from the US National Institutes of Health (K23AR057578) and an investigator-initiated grant from Forest Research Institute. Forest Research Institute provided the study drug and placebo. Y.C. Lee, MD, MMSc, Division of Rheumatology, Department of Medicine, Brigham and Women’s Hospital; E. Massarotti, MD, Division of Rheumatology, Brigham and Women’s Hospital; R.R. Edwards, PhD, Pain Management Center, Brigham and Women’s Hospital; B. Lu, MD, DrPH, Division of Rheumatology, Brigham and Women’s Hospital; C. Liu, PhD, Division of Rheumatology, Brigham and Women’s Hospital; Y. Lo, MPH, Division of Rheumatology, Brigham and Women’s Hospital; A. Wohlfahrt, BA, Division of Rheumatology, Brigham and Women’s Hospital; N.D. Kim, MD, Division of Rheumatology, Immunology and Allergy, Massachusetts General Hospital; D.J. Clauw, MD, University of Michigan; D.H. Solomon, MD, MPH, Division of Rheumatology, Brigham and Women’s Hospital. Address correspondence to Dr. Y.C. Lee, Division of Rheumatology, Immunology and Allergy, Brigham and Women’s Hospital, 75 Francis St., PBB-B3, Boston, Massachusetts 02115, USA. E-mail: ylee9@partners.org. Accepted for publication September 30, 2015.
Elena Massarotti
From the Division of Rheumatology, Immunology and Allergy, and Department of Anesthesiology, Brigham and Women’s Hospital; Division of Rheumatology, Immunology and Allergy, Massachusetts General Hospital, Boston, Massachusetts; Department of Anesthesiology, University of Michigan Medical Center, Ann Arbor, Michigan, USA. Funded by a grant from the US National Institutes of Health (K23AR057578) and an investigator-initiated grant from Forest Research Institute. Forest Research Institute provided the study drug and placebo. Y.C. Lee, MD, MMSc, Division of Rheumatology, Department of Medicine, Brigham and Women’s Hospital; E. Massarotti, MD, Division of Rheumatology, Brigham and Women’s Hospital; R.R. Edwards, PhD, Pain Management Center, Brigham and Women’s Hospital; B. Lu, MD, DrPH, Division of Rheumatology, Brigham and Women’s Hospital; C. Liu, PhD, Division of Rheumatology, Brigham and Women’s Hospital; Y. Lo, MPH, Division of Rheumatology, Brigham and Women’s Hospital; A. Wohlfahrt, BA, Division of Rheumatology, Brigham and Women’s Hospital; N.D. Kim, MD, Division of Rheumatology, Immunology and Allergy, Massachusetts General Hospital; D.J. Clauw, MD, University of Michigan; D.H. Solomon, MD, MPH, Division of Rheumatology, Brigham and Women’s Hospital. Address correspondence to Dr. Y.C. Lee, Division of Rheumatology, Immunology and Allergy, Brigham and Women’s Hospital, 75 Francis St., PBB-B3, Boston, Massachusetts 02115, USA. E-mail: ylee9@partners.org. Accepted for publication September 30, 2015.
Robert R. Edwards
From the Division of Rheumatology, Immunology and Allergy, and Department of Anesthesiology, Brigham and Women’s Hospital; Division of Rheumatology, Immunology and Allergy, Massachusetts General Hospital, Boston, Massachusetts; Department of Anesthesiology, University of Michigan Medical Center, Ann Arbor, Michigan, USA. Funded by a grant from the US National Institutes of Health (K23AR057578) and an investigator-initiated grant from Forest Research Institute. Forest Research Institute provided the study drug and placebo. Y.C. Lee, MD, MMSc, Division of Rheumatology, Department of Medicine, Brigham and Women’s Hospital; E. Massarotti, MD, Division of Rheumatology, Brigham and Women’s Hospital; R.R. Edwards, PhD, Pain Management Center, Brigham and Women’s Hospital; B. Lu, MD, DrPH, Division of Rheumatology, Brigham and Women’s Hospital; C. Liu, PhD, Division of Rheumatology, Brigham and Women’s Hospital; Y. Lo, MPH, Division of Rheumatology, Brigham and Women’s Hospital; A. Wohlfahrt, BA, Division of Rheumatology, Brigham and Women’s Hospital; N.D. Kim, MD, Division of Rheumatology, Immunology and Allergy, Massachusetts General Hospital; D.J. Clauw, MD, University of Michigan; D.H. Solomon, MD, MPH, Division of Rheumatology, Brigham and Women’s Hospital. Address correspondence to Dr. Y.C. Lee, Division of Rheumatology, Immunology and Allergy, Brigham and Women’s Hospital, 75 Francis St., PBB-B3, Boston, Massachusetts 02115, USA. E-mail: ylee9@partners.org. Accepted for publication September 30, 2015.
Bing Lu
From the Division of Rheumatology, Immunology and Allergy, and Department of Anesthesiology, Brigham and Women’s Hospital; Division of Rheumatology, Immunology and Allergy, Massachusetts General Hospital, Boston, Massachusetts; Department of Anesthesiology, University of Michigan Medical Center, Ann Arbor, Michigan, USA. Funded by a grant from the US National Institutes of Health (K23AR057578) and an investigator-initiated grant from Forest Research Institute. Forest Research Institute provided the study drug and placebo. Y.C. Lee, MD, MMSc, Division of Rheumatology, Department of Medicine, Brigham and Women’s Hospital; E. Massarotti, MD, Division of Rheumatology, Brigham and Women’s Hospital; R.R. Edwards, PhD, Pain Management Center, Brigham and Women’s Hospital; B. Lu, MD, DrPH, Division of Rheumatology, Brigham and Women’s Hospital; C. Liu, PhD, Division of Rheumatology, Brigham and Women’s Hospital; Y. Lo, MPH, Division of Rheumatology, Brigham and Women’s Hospital; A. Wohlfahrt, BA, Division of Rheumatology, Brigham and Women’s Hospital; N.D. Kim, MD, Division of Rheumatology, Immunology and Allergy, Massachusetts General Hospital; D.J. Clauw, MD, University of Michigan; D.H. Solomon, MD, MPH, Division of Rheumatology, Brigham and Women’s Hospital. Address correspondence to Dr. Y.C. Lee, Division of Rheumatology, Immunology and Allergy, Brigham and Women’s Hospital, 75 Francis St., PBB-B3, Boston, Massachusetts 02115, USA. E-mail: ylee9@partners.org. Accepted for publication September 30, 2015.
ChihChin Liu
From the Division of Rheumatology, Immunology and Allergy, and Department of Anesthesiology, Brigham and Women’s Hospital; Division of Rheumatology, Immunology and Allergy, Massachusetts General Hospital, Boston, Massachusetts; Department of Anesthesiology, University of Michigan Medical Center, Ann Arbor, Michigan, USA. Funded by a grant from the US National Institutes of Health (K23AR057578) and an investigator-initiated grant from Forest Research Institute. Forest Research Institute provided the study drug and placebo. Y.C. Lee, MD, MMSc, Division of Rheumatology, Department of Medicine, Brigham and Women’s Hospital; E. Massarotti, MD, Division of Rheumatology, Brigham and Women’s Hospital; R.R. Edwards, PhD, Pain Management Center, Brigham and Women’s Hospital; B. Lu, MD, DrPH, Division of Rheumatology, Brigham and Women’s Hospital; C. Liu, PhD, Division of Rheumatology, Brigham and Women’s Hospital; Y. Lo, MPH, Division of Rheumatology, Brigham and Women’s Hospital; A. Wohlfahrt, BA, Division of Rheumatology, Brigham and Women’s Hospital; N.D. Kim, MD, Division of Rheumatology, Immunology and Allergy, Massachusetts General Hospital; D.J. Clauw, MD, University of Michigan; D.H. Solomon, MD, MPH, Division of Rheumatology, Brigham and Women’s Hospital. Address correspondence to Dr. Y.C. Lee, Division of Rheumatology, Immunology and Allergy, Brigham and Women’s Hospital, 75 Francis St., PBB-B3, Boston, Massachusetts 02115, USA. E-mail: ylee9@partners.org. Accepted for publication September 30, 2015.
Yuanyu Lo
From the Division of Rheumatology, Immunology and Allergy, and Department of Anesthesiology, Brigham and Women’s Hospital; Division of Rheumatology, Immunology and Allergy, Massachusetts General Hospital, Boston, Massachusetts; Department of Anesthesiology, University of Michigan Medical Center, Ann Arbor, Michigan, USA. Funded by a grant from the US National Institutes of Health (K23AR057578) and an investigator-initiated grant from Forest Research Institute. Forest Research Institute provided the study drug and placebo. Y.C. Lee, MD, MMSc, Division of Rheumatology, Department of Medicine, Brigham and Women’s Hospital; E. Massarotti, MD, Division of Rheumatology, Brigham and Women’s Hospital; R.R. Edwards, PhD, Pain Management Center, Brigham and Women’s Hospital; B. Lu, MD, DrPH, Division of Rheumatology, Brigham and Women’s Hospital; C. Liu, PhD, Division of Rheumatology, Brigham and Women’s Hospital; Y. Lo, MPH, Division of Rheumatology, Brigham and Women’s Hospital; A. Wohlfahrt, BA, Division of Rheumatology, Brigham and Women’s Hospital; N.D. Kim, MD, Division of Rheumatology, Immunology and Allergy, Massachusetts General Hospital; D.J. Clauw, MD, University of Michigan; D.H. Solomon, MD, MPH, Division of Rheumatology, Brigham and Women’s Hospital. Address correspondence to Dr. Y.C. Lee, Division of Rheumatology, Immunology and Allergy, Brigham and Women’s Hospital, 75 Francis St., PBB-B3, Boston, Massachusetts 02115, USA. E-mail: ylee9@partners.org. Accepted for publication September 30, 2015.
Alyssa Wohlfahrt
From the Division of Rheumatology, Immunology and Allergy, and Department of Anesthesiology, Brigham and Women’s Hospital; Division of Rheumatology, Immunology and Allergy, Massachusetts General Hospital, Boston, Massachusetts; Department of Anesthesiology, University of Michigan Medical Center, Ann Arbor, Michigan, USA. Funded by a grant from the US National Institutes of Health (K23AR057578) and an investigator-initiated grant from Forest Research Institute. Forest Research Institute provided the study drug and placebo. Y.C. Lee, MD, MMSc, Division of Rheumatology, Department of Medicine, Brigham and Women’s Hospital; E. Massarotti, MD, Division of Rheumatology, Brigham and Women’s Hospital; R.R. Edwards, PhD, Pain Management Center, Brigham and Women’s Hospital; B. Lu, MD, DrPH, Division of Rheumatology, Brigham and Women’s Hospital; C. Liu, PhD, Division of Rheumatology, Brigham and Women’s Hospital; Y. Lo, MPH, Division of Rheumatology, Brigham and Women’s Hospital; A. Wohlfahrt, BA, Division of Rheumatology, Brigham and Women’s Hospital; N.D. Kim, MD, Division of Rheumatology, Immunology and Allergy, Massachusetts General Hospital; D.J. Clauw, MD, University of Michigan; D.H. Solomon, MD, MPH, Division of Rheumatology, Brigham and Women’s Hospital. Address correspondence to Dr. Y.C. Lee, Division of Rheumatology, Immunology and Allergy, Brigham and Women’s Hospital, 75 Francis St., PBB-B3, Boston, Massachusetts 02115, USA. E-mail: ylee9@partners.org. Accepted for publication September 30, 2015.
Nancy D. Kim
From the Division of Rheumatology, Immunology and Allergy, and Department of Anesthesiology, Brigham and Women’s Hospital; Division of Rheumatology, Immunology and Allergy, Massachusetts General Hospital, Boston, Massachusetts; Department of Anesthesiology, University of Michigan Medical Center, Ann Arbor, Michigan, USA. Funded by a grant from the US National Institutes of Health (K23AR057578) and an investigator-initiated grant from Forest Research Institute. Forest Research Institute provided the study drug and placebo. Y.C. Lee, MD, MMSc, Division of Rheumatology, Department of Medicine, Brigham and Women’s Hospital; E. Massarotti, MD, Division of Rheumatology, Brigham and Women’s Hospital; R.R. Edwards, PhD, Pain Management Center, Brigham and Women’s Hospital; B. Lu, MD, DrPH, Division of Rheumatology, Brigham and Women’s Hospital; C. Liu, PhD, Division of Rheumatology, Brigham and Women’s Hospital; Y. Lo, MPH, Division of Rheumatology, Brigham and Women’s Hospital; A. Wohlfahrt, BA, Division of Rheumatology, Brigham and Women’s Hospital; N.D. Kim, MD, Division of Rheumatology, Immunology and Allergy, Massachusetts General Hospital; D.J. Clauw, MD, University of Michigan; D.H. Solomon, MD, MPH, Division of Rheumatology, Brigham and Women’s Hospital. Address correspondence to Dr. Y.C. Lee, Division of Rheumatology, Immunology and Allergy, Brigham and Women’s Hospital, 75 Francis St., PBB-B3, Boston, Massachusetts 02115, USA. E-mail: ylee9@partners.org. Accepted for publication September 30, 2015.
Daniel J. Clauw
From the Division of Rheumatology, Immunology and Allergy, and Department of Anesthesiology, Brigham and Women’s Hospital; Division of Rheumatology, Immunology and Allergy, Massachusetts General Hospital, Boston, Massachusetts; Department of Anesthesiology, University of Michigan Medical Center, Ann Arbor, Michigan, USA. Funded by a grant from the US National Institutes of Health (K23AR057578) and an investigator-initiated grant from Forest Research Institute. Forest Research Institute provided the study drug and placebo. Y.C. Lee, MD, MMSc, Division of Rheumatology, Department of Medicine, Brigham and Women’s Hospital; E. Massarotti, MD, Division of Rheumatology, Brigham and Women’s Hospital; R.R. Edwards, PhD, Pain Management Center, Brigham and Women’s Hospital; B. Lu, MD, DrPH, Division of Rheumatology, Brigham and Women’s Hospital; C. Liu, PhD, Division of Rheumatology, Brigham and Women’s Hospital; Y. Lo, MPH, Division of Rheumatology, Brigham and Women’s Hospital; A. Wohlfahrt, BA, Division of Rheumatology, Brigham and Women’s Hospital; N.D. Kim, MD, Division of Rheumatology, Immunology and Allergy, Massachusetts General Hospital; D.J. Clauw, MD, University of Michigan; D.H. Solomon, MD, MPH, Division of Rheumatology, Brigham and Women’s Hospital. Address correspondence to Dr. Y.C. Lee, Division of Rheumatology, Immunology and Allergy, Brigham and Women’s Hospital, 75 Francis St., PBB-B3, Boston, Massachusetts 02115, USA. E-mail: ylee9@partners.org. Accepted for publication September 30, 2015.
Daniel H. Solomon
From the Division of Rheumatology, Immunology and Allergy, and Department of Anesthesiology, Brigham and Women’s Hospital; Division of Rheumatology, Immunology and Allergy, Massachusetts General Hospital, Boston, Massachusetts; Department of Anesthesiology, University of Michigan Medical Center, Ann Arbor, Michigan, USA. Funded by a grant from the US National Institutes of Health (K23AR057578) and an investigator-initiated grant from Forest Research Institute. Forest Research Institute provided the study drug and placebo. Y.C. Lee, MD, MMSc, Division of Rheumatology, Department of Medicine, Brigham and Women’s Hospital; E. Massarotti, MD, Division of Rheumatology, Brigham and Women’s Hospital; R.R. Edwards, PhD, Pain Management Center, Brigham and Women’s Hospital; B. Lu, MD, DrPH, Division of Rheumatology, Brigham and Women’s Hospital; C. Liu, PhD, Division of Rheumatology, Brigham and Women’s Hospital; Y. Lo, MPH, Division of Rheumatology, Brigham and Women’s Hospital; A. Wohlfahrt, BA, Division of Rheumatology, Brigham and Women’s Hospital; N.D. Kim, MD, Division of Rheumatology, Immunology and Allergy, Massachusetts General Hospital; D.J. Clauw, MD, University of Michigan; D.H. Solomon, MD, MPH, Division of Rheumatology, Brigham and Women’s Hospital. Address correspondence to Dr. Y.C. Lee, Division of Rheumatology, Immunology and Allergy, Brigham and Women’s Hospital, 75 Francis St., PBB-B3, Boston, Massachusetts 02115, USA. E-mail: ylee9@partners.org. Accepted for publication September 30, 2015.
In this issue
The Journal of Rheumatology
Vol. 51, Issue 4
1 Apr 2024
Effect of Milnacipran on Pain in Patients with Rheumatoid Arthritis with Widespread Pain: A Randomized Blinded Crossover Trial
Yvonne C. Lee, Elena Massarotti, Robert R. Edwards, Bing Lu, ChihChin Liu, Yuanyu Lo, Alyssa Wohlfahrt, Nancy D. Kim, Daniel J. Clauw, Daniel H. Solomon
The Journal of Rheumatology Dec 2015, jrheum.150550; DOI: 10.3899/jrheum.150550
Effect of Milnacipran on Pain in Patients with Rheumatoid Arthritis with Widespread Pain: A Randomized Blinded Crossover Trial
Yvonne C. Lee, Elena Massarotti, Robert R. Edwards, Bing Lu, ChihChin Liu, Yuanyu Lo, Alyssa Wohlfahrt, Nancy D. Kim, Daniel J. Clauw, Daniel H. Solomon
The Journal of Rheumatology Dec 2015, jrheum.150550; DOI: 10.3899/jrheum.150550