Research ArticleArticle
MicroRNA-10a Regulation of Proinflammatory Mediators: An Important Component of Untreated Juvenile Dermatomyositis
Dong Xu, Chiang-Ching Huang, Akadia Kachaochana, Gabrielle A. Morgan, Maria F. Bonaldo, Marcelo B. Soares, Fabricio Costa, John Sarwark, Simone T. Sredni and Lauren M. Pachman
The Journal of Rheumatology December 2015, jrheum.141474; DOI: https://doi.org/10.3899/jrheum.141474
Dong Xu
From the Stanley Manne Children’s Research Institute; Ann and Robert H. Lurie Children’s Hospital of Chicago; Department of Pediatrics, Division of Rheumatology, and Cancer Biology and Epigenomics Program, and Department of Orthopedic Surgery, and Department of Pediatric Neurosurgery, Northwestern University Feinberg School of Medicine, Chicago, Illinois; Cure Juvenile Myositis (JM) Program of Excellence in JM Research and Care, Encinitas, California; Joseph J. Zilber School of Public Health, University of Wisconsin, Milwaukee, Wisconsin, USA. Supported by US National Institutes of Health NR012692 and the Cure JM Foundation. D. Xu, MD, Research Assistant Professor, Stanley Manne Children’s Research Institute, and Cure JM Program of Excellence in JM Research and Care, and Department of Pediatrics, Division of Rheumatology, Northwestern University Feinberg School of Medicine; C.C. Huang, PhD, Associate Professor, Joseph J. Zilber School of Public Health, University of Wisconsin; A. Kachaochana, BS, Laboratory Technician 2, Stanley Manne Children’s Research Institute, and Cure JM Program of Excellence in JM Research and Care; G.A. Morgan, MA, Database Manager, Stanley Manne Children’s Research Institute, and Cure JM Program of Excellence in JM Research and Care; M. Bonaldo, Ph.D., Research Associate Professor, Stanley Manne Children’s Research Institute, and Cancer Biology and Epigenomics Program, Northwestern University Feinberg School of Medicine; M.B. Soares, PhD, Rachelle and Mark Gordon Endowed Professorship in Cancer Biology and Epigenomics, Professor of Pediatrics, Stanley Manne Children’s Research Institute, and Cancer Biology and Epigenomics Program, Northwestern University Feinberg School of Medicine; F. Costa, PhD, Associate Professor of Pediatrics, Stanley Manne Children’s Research Institute, and Cancer Biology and Epigenomics Program, Northwestern University Feinberg School of Medicine; J.F. Sarwark, MD, Professor of Orthopedic Surgery, Department of Orthopedic Surgery, Northwestern University Feinberg School of Medicine; S.T. Sredni, MD, PhD, Research Assistant Professor, Pediatric Neurosurgery, Northwestern University Feinberg School of Medicine; L.M. Pachman, MD, Professor of Pediatrics, Stanley Manne Children’s Research Institute, and Cure JM Center of Excellence in JM Research and Care, and Department of Pediatrics, Division of Rheumatology, Northwestern University Feinberg School of Medicine. Address correspondence to Dr. L.M. Pachman, Stanley Manne Children’s Research Institute, Department of Pediatrics, 225 East Chicago Ave., Box 212, Chicago, Illinois 60611, USA. E-mail: pachman@northwestern.edu. Accepted for publication August 17, 2015.
Chiang-Ching Huang
From the Stanley Manne Children’s Research Institute; Ann and Robert H. Lurie Children’s Hospital of Chicago; Department of Pediatrics, Division of Rheumatology, and Cancer Biology and Epigenomics Program, and Department of Orthopedic Surgery, and Department of Pediatric Neurosurgery, Northwestern University Feinberg School of Medicine, Chicago, Illinois; Cure Juvenile Myositis (JM) Program of Excellence in JM Research and Care, Encinitas, California; Joseph J. Zilber School of Public Health, University of Wisconsin, Milwaukee, Wisconsin, USA. Supported by US National Institutes of Health NR012692 and the Cure JM Foundation. D. Xu, MD, Research Assistant Professor, Stanley Manne Children’s Research Institute, and Cure JM Program of Excellence in JM Research and Care, and Department of Pediatrics, Division of Rheumatology, Northwestern University Feinberg School of Medicine; C.C. Huang, PhD, Associate Professor, Joseph J. Zilber School of Public Health, University of Wisconsin; A. Kachaochana, BS, Laboratory Technician 2, Stanley Manne Children’s Research Institute, and Cure JM Program of Excellence in JM Research and Care; G.A. Morgan, MA, Database Manager, Stanley Manne Children’s Research Institute, and Cure JM Program of Excellence in JM Research and Care; M. Bonaldo, Ph.D., Research Associate Professor, Stanley Manne Children’s Research Institute, and Cancer Biology and Epigenomics Program, Northwestern University Feinberg School of Medicine; M.B. Soares, PhD, Rachelle and Mark Gordon Endowed Professorship in Cancer Biology and Epigenomics, Professor of Pediatrics, Stanley Manne Children’s Research Institute, and Cancer Biology and Epigenomics Program, Northwestern University Feinberg School of Medicine; F. Costa, PhD, Associate Professor of Pediatrics, Stanley Manne Children’s Research Institute, and Cancer Biology and Epigenomics Program, Northwestern University Feinberg School of Medicine; J.F. Sarwark, MD, Professor of Orthopedic Surgery, Department of Orthopedic Surgery, Northwestern University Feinberg School of Medicine; S.T. Sredni, MD, PhD, Research Assistant Professor, Pediatric Neurosurgery, Northwestern University Feinberg School of Medicine; L.M. Pachman, MD, Professor of Pediatrics, Stanley Manne Children’s Research Institute, and Cure JM Center of Excellence in JM Research and Care, and Department of Pediatrics, Division of Rheumatology, Northwestern University Feinberg School of Medicine. Address correspondence to Dr. L.M. Pachman, Stanley Manne Children’s Research Institute, Department of Pediatrics, 225 East Chicago Ave., Box 212, Chicago, Illinois 60611, USA. E-mail: pachman@northwestern.edu. Accepted for publication August 17, 2015.
Akadia Kachaochana
From the Stanley Manne Children’s Research Institute; Ann and Robert H. Lurie Children’s Hospital of Chicago; Department of Pediatrics, Division of Rheumatology, and Cancer Biology and Epigenomics Program, and Department of Orthopedic Surgery, and Department of Pediatric Neurosurgery, Northwestern University Feinberg School of Medicine, Chicago, Illinois; Cure Juvenile Myositis (JM) Program of Excellence in JM Research and Care, Encinitas, California; Joseph J. Zilber School of Public Health, University of Wisconsin, Milwaukee, Wisconsin, USA. Supported by US National Institutes of Health NR012692 and the Cure JM Foundation. D. Xu, MD, Research Assistant Professor, Stanley Manne Children’s Research Institute, and Cure JM Program of Excellence in JM Research and Care, and Department of Pediatrics, Division of Rheumatology, Northwestern University Feinberg School of Medicine; C.C. Huang, PhD, Associate Professor, Joseph J. Zilber School of Public Health, University of Wisconsin; A. Kachaochana, BS, Laboratory Technician 2, Stanley Manne Children’s Research Institute, and Cure JM Program of Excellence in JM Research and Care; G.A. Morgan, MA, Database Manager, Stanley Manne Children’s Research Institute, and Cure JM Program of Excellence in JM Research and Care; M. Bonaldo, Ph.D., Research Associate Professor, Stanley Manne Children’s Research Institute, and Cancer Biology and Epigenomics Program, Northwestern University Feinberg School of Medicine; M.B. Soares, PhD, Rachelle and Mark Gordon Endowed Professorship in Cancer Biology and Epigenomics, Professor of Pediatrics, Stanley Manne Children’s Research Institute, and Cancer Biology and Epigenomics Program, Northwestern University Feinberg School of Medicine; F. Costa, PhD, Associate Professor of Pediatrics, Stanley Manne Children’s Research Institute, and Cancer Biology and Epigenomics Program, Northwestern University Feinberg School of Medicine; J.F. Sarwark, MD, Professor of Orthopedic Surgery, Department of Orthopedic Surgery, Northwestern University Feinberg School of Medicine; S.T. Sredni, MD, PhD, Research Assistant Professor, Pediatric Neurosurgery, Northwestern University Feinberg School of Medicine; L.M. Pachman, MD, Professor of Pediatrics, Stanley Manne Children’s Research Institute, and Cure JM Center of Excellence in JM Research and Care, and Department of Pediatrics, Division of Rheumatology, Northwestern University Feinberg School of Medicine. Address correspondence to Dr. L.M. Pachman, Stanley Manne Children’s Research Institute, Department of Pediatrics, 225 East Chicago Ave., Box 212, Chicago, Illinois 60611, USA. E-mail: pachman@northwestern.edu. Accepted for publication August 17, 2015.
Gabrielle A. Morgan
From the Stanley Manne Children’s Research Institute; Ann and Robert H. Lurie Children’s Hospital of Chicago; Department of Pediatrics, Division of Rheumatology, and Cancer Biology and Epigenomics Program, and Department of Orthopedic Surgery, and Department of Pediatric Neurosurgery, Northwestern University Feinberg School of Medicine, Chicago, Illinois; Cure Juvenile Myositis (JM) Program of Excellence in JM Research and Care, Encinitas, California; Joseph J. Zilber School of Public Health, University of Wisconsin, Milwaukee, Wisconsin, USA. Supported by US National Institutes of Health NR012692 and the Cure JM Foundation. D. Xu, MD, Research Assistant Professor, Stanley Manne Children’s Research Institute, and Cure JM Program of Excellence in JM Research and Care, and Department of Pediatrics, Division of Rheumatology, Northwestern University Feinberg School of Medicine; C.C. Huang, PhD, Associate Professor, Joseph J. Zilber School of Public Health, University of Wisconsin; A. Kachaochana, BS, Laboratory Technician 2, Stanley Manne Children’s Research Institute, and Cure JM Program of Excellence in JM Research and Care; G.A. Morgan, MA, Database Manager, Stanley Manne Children’s Research Institute, and Cure JM Program of Excellence in JM Research and Care; M. Bonaldo, Ph.D., Research Associate Professor, Stanley Manne Children’s Research Institute, and Cancer Biology and Epigenomics Program, Northwestern University Feinberg School of Medicine; M.B. Soares, PhD, Rachelle and Mark Gordon Endowed Professorship in Cancer Biology and Epigenomics, Professor of Pediatrics, Stanley Manne Children’s Research Institute, and Cancer Biology and Epigenomics Program, Northwestern University Feinberg School of Medicine; F. Costa, PhD, Associate Professor of Pediatrics, Stanley Manne Children’s Research Institute, and Cancer Biology and Epigenomics Program, Northwestern University Feinberg School of Medicine; J.F. Sarwark, MD, Professor of Orthopedic Surgery, Department of Orthopedic Surgery, Northwestern University Feinberg School of Medicine; S.T. Sredni, MD, PhD, Research Assistant Professor, Pediatric Neurosurgery, Northwestern University Feinberg School of Medicine; L.M. Pachman, MD, Professor of Pediatrics, Stanley Manne Children’s Research Institute, and Cure JM Center of Excellence in JM Research and Care, and Department of Pediatrics, Division of Rheumatology, Northwestern University Feinberg School of Medicine. Address correspondence to Dr. L.M. Pachman, Stanley Manne Children’s Research Institute, Department of Pediatrics, 225 East Chicago Ave., Box 212, Chicago, Illinois 60611, USA. E-mail: pachman@northwestern.edu. Accepted for publication August 17, 2015.
Maria F. Bonaldo
From the Stanley Manne Children’s Research Institute; Ann and Robert H. Lurie Children’s Hospital of Chicago; Department of Pediatrics, Division of Rheumatology, and Cancer Biology and Epigenomics Program, and Department of Orthopedic Surgery, and Department of Pediatric Neurosurgery, Northwestern University Feinberg School of Medicine, Chicago, Illinois; Cure Juvenile Myositis (JM) Program of Excellence in JM Research and Care, Encinitas, California; Joseph J. Zilber School of Public Health, University of Wisconsin, Milwaukee, Wisconsin, USA. Supported by US National Institutes of Health NR012692 and the Cure JM Foundation. D. Xu, MD, Research Assistant Professor, Stanley Manne Children’s Research Institute, and Cure JM Program of Excellence in JM Research and Care, and Department of Pediatrics, Division of Rheumatology, Northwestern University Feinberg School of Medicine; C.C. Huang, PhD, Associate Professor, Joseph J. Zilber School of Public Health, University of Wisconsin; A. Kachaochana, BS, Laboratory Technician 2, Stanley Manne Children’s Research Institute, and Cure JM Program of Excellence in JM Research and Care; G.A. Morgan, MA, Database Manager, Stanley Manne Children’s Research Institute, and Cure JM Program of Excellence in JM Research and Care; M. Bonaldo, Ph.D., Research Associate Professor, Stanley Manne Children’s Research Institute, and Cancer Biology and Epigenomics Program, Northwestern University Feinberg School of Medicine; M.B. Soares, PhD, Rachelle and Mark Gordon Endowed Professorship in Cancer Biology and Epigenomics, Professor of Pediatrics, Stanley Manne Children’s Research Institute, and Cancer Biology and Epigenomics Program, Northwestern University Feinberg School of Medicine; F. Costa, PhD, Associate Professor of Pediatrics, Stanley Manne Children’s Research Institute, and Cancer Biology and Epigenomics Program, Northwestern University Feinberg School of Medicine; J.F. Sarwark, MD, Professor of Orthopedic Surgery, Department of Orthopedic Surgery, Northwestern University Feinberg School of Medicine; S.T. Sredni, MD, PhD, Research Assistant Professor, Pediatric Neurosurgery, Northwestern University Feinberg School of Medicine; L.M. Pachman, MD, Professor of Pediatrics, Stanley Manne Children’s Research Institute, and Cure JM Center of Excellence in JM Research and Care, and Department of Pediatrics, Division of Rheumatology, Northwestern University Feinberg School of Medicine. Address correspondence to Dr. L.M. Pachman, Stanley Manne Children’s Research Institute, Department of Pediatrics, 225 East Chicago Ave., Box 212, Chicago, Illinois 60611, USA. E-mail: pachman@northwestern.edu. Accepted for publication August 17, 2015.
Marcelo B. Soares
From the Stanley Manne Children’s Research Institute; Ann and Robert H. Lurie Children’s Hospital of Chicago; Department of Pediatrics, Division of Rheumatology, and Cancer Biology and Epigenomics Program, and Department of Orthopedic Surgery, and Department of Pediatric Neurosurgery, Northwestern University Feinberg School of Medicine, Chicago, Illinois; Cure Juvenile Myositis (JM) Program of Excellence in JM Research and Care, Encinitas, California; Joseph J. Zilber School of Public Health, University of Wisconsin, Milwaukee, Wisconsin, USA. Supported by US National Institutes of Health NR012692 and the Cure JM Foundation. D. Xu, MD, Research Assistant Professor, Stanley Manne Children’s Research Institute, and Cure JM Program of Excellence in JM Research and Care, and Department of Pediatrics, Division of Rheumatology, Northwestern University Feinberg School of Medicine; C.C. Huang, PhD, Associate Professor, Joseph J. Zilber School of Public Health, University of Wisconsin; A. Kachaochana, BS, Laboratory Technician 2, Stanley Manne Children’s Research Institute, and Cure JM Program of Excellence in JM Research and Care; G.A. Morgan, MA, Database Manager, Stanley Manne Children’s Research Institute, and Cure JM Program of Excellence in JM Research and Care; M. Bonaldo, Ph.D., Research Associate Professor, Stanley Manne Children’s Research Institute, and Cancer Biology and Epigenomics Program, Northwestern University Feinberg School of Medicine; M.B. Soares, PhD, Rachelle and Mark Gordon Endowed Professorship in Cancer Biology and Epigenomics, Professor of Pediatrics, Stanley Manne Children’s Research Institute, and Cancer Biology and Epigenomics Program, Northwestern University Feinberg School of Medicine; F. Costa, PhD, Associate Professor of Pediatrics, Stanley Manne Children’s Research Institute, and Cancer Biology and Epigenomics Program, Northwestern University Feinberg School of Medicine; J.F. Sarwark, MD, Professor of Orthopedic Surgery, Department of Orthopedic Surgery, Northwestern University Feinberg School of Medicine; S.T. Sredni, MD, PhD, Research Assistant Professor, Pediatric Neurosurgery, Northwestern University Feinberg School of Medicine; L.M. Pachman, MD, Professor of Pediatrics, Stanley Manne Children’s Research Institute, and Cure JM Center of Excellence in JM Research and Care, and Department of Pediatrics, Division of Rheumatology, Northwestern University Feinberg School of Medicine. Address correspondence to Dr. L.M. Pachman, Stanley Manne Children’s Research Institute, Department of Pediatrics, 225 East Chicago Ave., Box 212, Chicago, Illinois 60611, USA. E-mail: pachman@northwestern.edu. Accepted for publication August 17, 2015.
Fabricio Costa
From the Stanley Manne Children’s Research Institute; Ann and Robert H. Lurie Children’s Hospital of Chicago; Department of Pediatrics, Division of Rheumatology, and Cancer Biology and Epigenomics Program, and Department of Orthopedic Surgery, and Department of Pediatric Neurosurgery, Northwestern University Feinberg School of Medicine, Chicago, Illinois; Cure Juvenile Myositis (JM) Program of Excellence in JM Research and Care, Encinitas, California; Joseph J. Zilber School of Public Health, University of Wisconsin, Milwaukee, Wisconsin, USA. Supported by US National Institutes of Health NR012692 and the Cure JM Foundation. D. Xu, MD, Research Assistant Professor, Stanley Manne Children’s Research Institute, and Cure JM Program of Excellence in JM Research and Care, and Department of Pediatrics, Division of Rheumatology, Northwestern University Feinberg School of Medicine; C.C. Huang, PhD, Associate Professor, Joseph J. Zilber School of Public Health, University of Wisconsin; A. Kachaochana, BS, Laboratory Technician 2, Stanley Manne Children’s Research Institute, and Cure JM Program of Excellence in JM Research and Care; G.A. Morgan, MA, Database Manager, Stanley Manne Children’s Research Institute, and Cure JM Program of Excellence in JM Research and Care; M. Bonaldo, Ph.D., Research Associate Professor, Stanley Manne Children’s Research Institute, and Cancer Biology and Epigenomics Program, Northwestern University Feinberg School of Medicine; M.B. Soares, PhD, Rachelle and Mark Gordon Endowed Professorship in Cancer Biology and Epigenomics, Professor of Pediatrics, Stanley Manne Children’s Research Institute, and Cancer Biology and Epigenomics Program, Northwestern University Feinberg School of Medicine; F. Costa, PhD, Associate Professor of Pediatrics, Stanley Manne Children’s Research Institute, and Cancer Biology and Epigenomics Program, Northwestern University Feinberg School of Medicine; J.F. Sarwark, MD, Professor of Orthopedic Surgery, Department of Orthopedic Surgery, Northwestern University Feinberg School of Medicine; S.T. Sredni, MD, PhD, Research Assistant Professor, Pediatric Neurosurgery, Northwestern University Feinberg School of Medicine; L.M. Pachman, MD, Professor of Pediatrics, Stanley Manne Children’s Research Institute, and Cure JM Center of Excellence in JM Research and Care, and Department of Pediatrics, Division of Rheumatology, Northwestern University Feinberg School of Medicine. Address correspondence to Dr. L.M. Pachman, Stanley Manne Children’s Research Institute, Department of Pediatrics, 225 East Chicago Ave., Box 212, Chicago, Illinois 60611, USA. E-mail: pachman@northwestern.edu. Accepted for publication August 17, 2015.
John Sarwark
From the Stanley Manne Children’s Research Institute; Ann and Robert H. Lurie Children’s Hospital of Chicago; Department of Pediatrics, Division of Rheumatology, and Cancer Biology and Epigenomics Program, and Department of Orthopedic Surgery, and Department of Pediatric Neurosurgery, Northwestern University Feinberg School of Medicine, Chicago, Illinois; Cure Juvenile Myositis (JM) Program of Excellence in JM Research and Care, Encinitas, California; Joseph J. Zilber School of Public Health, University of Wisconsin, Milwaukee, Wisconsin, USA. Supported by US National Institutes of Health NR012692 and the Cure JM Foundation. D. Xu, MD, Research Assistant Professor, Stanley Manne Children’s Research Institute, and Cure JM Program of Excellence in JM Research and Care, and Department of Pediatrics, Division of Rheumatology, Northwestern University Feinberg School of Medicine; C.C. Huang, PhD, Associate Professor, Joseph J. Zilber School of Public Health, University of Wisconsin; A. Kachaochana, BS, Laboratory Technician 2, Stanley Manne Children’s Research Institute, and Cure JM Program of Excellence in JM Research and Care; G.A. Morgan, MA, Database Manager, Stanley Manne Children’s Research Institute, and Cure JM Program of Excellence in JM Research and Care; M. Bonaldo, Ph.D., Research Associate Professor, Stanley Manne Children’s Research Institute, and Cancer Biology and Epigenomics Program, Northwestern University Feinberg School of Medicine; M.B. Soares, PhD, Rachelle and Mark Gordon Endowed Professorship in Cancer Biology and Epigenomics, Professor of Pediatrics, Stanley Manne Children’s Research Institute, and Cancer Biology and Epigenomics Program, Northwestern University Feinberg School of Medicine; F. Costa, PhD, Associate Professor of Pediatrics, Stanley Manne Children’s Research Institute, and Cancer Biology and Epigenomics Program, Northwestern University Feinberg School of Medicine; J.F. Sarwark, MD, Professor of Orthopedic Surgery, Department of Orthopedic Surgery, Northwestern University Feinberg School of Medicine; S.T. Sredni, MD, PhD, Research Assistant Professor, Pediatric Neurosurgery, Northwestern University Feinberg School of Medicine; L.M. Pachman, MD, Professor of Pediatrics, Stanley Manne Children’s Research Institute, and Cure JM Center of Excellence in JM Research and Care, and Department of Pediatrics, Division of Rheumatology, Northwestern University Feinberg School of Medicine. Address correspondence to Dr. L.M. Pachman, Stanley Manne Children’s Research Institute, Department of Pediatrics, 225 East Chicago Ave., Box 212, Chicago, Illinois 60611, USA. E-mail: pachman@northwestern.edu. Accepted for publication August 17, 2015.
Simone T. Sredni
From the Stanley Manne Children’s Research Institute; Ann and Robert H. Lurie Children’s Hospital of Chicago; Department of Pediatrics, Division of Rheumatology, and Cancer Biology and Epigenomics Program, and Department of Orthopedic Surgery, and Department of Pediatric Neurosurgery, Northwestern University Feinberg School of Medicine, Chicago, Illinois; Cure Juvenile Myositis (JM) Program of Excellence in JM Research and Care, Encinitas, California; Joseph J. Zilber School of Public Health, University of Wisconsin, Milwaukee, Wisconsin, USA. Supported by US National Institutes of Health NR012692 and the Cure JM Foundation. D. Xu, MD, Research Assistant Professor, Stanley Manne Children’s Research Institute, and Cure JM Program of Excellence in JM Research and Care, and Department of Pediatrics, Division of Rheumatology, Northwestern University Feinberg School of Medicine; C.C. Huang, PhD, Associate Professor, Joseph J. Zilber School of Public Health, University of Wisconsin; A. Kachaochana, BS, Laboratory Technician 2, Stanley Manne Children’s Research Institute, and Cure JM Program of Excellence in JM Research and Care; G.A. Morgan, MA, Database Manager, Stanley Manne Children’s Research Institute, and Cure JM Program of Excellence in JM Research and Care; M. Bonaldo, Ph.D., Research Associate Professor, Stanley Manne Children’s Research Institute, and Cancer Biology and Epigenomics Program, Northwestern University Feinberg School of Medicine; M.B. Soares, PhD, Rachelle and Mark Gordon Endowed Professorship in Cancer Biology and Epigenomics, Professor of Pediatrics, Stanley Manne Children’s Research Institute, and Cancer Biology and Epigenomics Program, Northwestern University Feinberg School of Medicine; F. Costa, PhD, Associate Professor of Pediatrics, Stanley Manne Children’s Research Institute, and Cancer Biology and Epigenomics Program, Northwestern University Feinberg School of Medicine; J.F. Sarwark, MD, Professor of Orthopedic Surgery, Department of Orthopedic Surgery, Northwestern University Feinberg School of Medicine; S.T. Sredni, MD, PhD, Research Assistant Professor, Pediatric Neurosurgery, Northwestern University Feinberg School of Medicine; L.M. Pachman, MD, Professor of Pediatrics, Stanley Manne Children’s Research Institute, and Cure JM Center of Excellence in JM Research and Care, and Department of Pediatrics, Division of Rheumatology, Northwestern University Feinberg School of Medicine. Address correspondence to Dr. L.M. Pachman, Stanley Manne Children’s Research Institute, Department of Pediatrics, 225 East Chicago Ave., Box 212, Chicago, Illinois 60611, USA. E-mail: pachman@northwestern.edu. Accepted for publication August 17, 2015.
Lauren M. Pachman
From the Stanley Manne Children’s Research Institute; Ann and Robert H. Lurie Children’s Hospital of Chicago; Department of Pediatrics, Division of Rheumatology, and Cancer Biology and Epigenomics Program, and Department of Orthopedic Surgery, and Department of Pediatric Neurosurgery, Northwestern University Feinberg School of Medicine, Chicago, Illinois; Cure Juvenile Myositis (JM) Program of Excellence in JM Research and Care, Encinitas, California; Joseph J. Zilber School of Public Health, University of Wisconsin, Milwaukee, Wisconsin, USA. Supported by US National Institutes of Health NR012692 and the Cure JM Foundation. D. Xu, MD, Research Assistant Professor, Stanley Manne Children’s Research Institute, and Cure JM Program of Excellence in JM Research and Care, and Department of Pediatrics, Division of Rheumatology, Northwestern University Feinberg School of Medicine; C.C. Huang, PhD, Associate Professor, Joseph J. Zilber School of Public Health, University of Wisconsin; A. Kachaochana, BS, Laboratory Technician 2, Stanley Manne Children’s Research Institute, and Cure JM Program of Excellence in JM Research and Care; G.A. Morgan, MA, Database Manager, Stanley Manne Children’s Research Institute, and Cure JM Program of Excellence in JM Research and Care; M. Bonaldo, Ph.D., Research Associate Professor, Stanley Manne Children’s Research Institute, and Cancer Biology and Epigenomics Program, Northwestern University Feinberg School of Medicine; M.B. Soares, PhD, Rachelle and Mark Gordon Endowed Professorship in Cancer Biology and Epigenomics, Professor of Pediatrics, Stanley Manne Children’s Research Institute, and Cancer Biology and Epigenomics Program, Northwestern University Feinberg School of Medicine; F. Costa, PhD, Associate Professor of Pediatrics, Stanley Manne Children’s Research Institute, and Cancer Biology and Epigenomics Program, Northwestern University Feinberg School of Medicine; J.F. Sarwark, MD, Professor of Orthopedic Surgery, Department of Orthopedic Surgery, Northwestern University Feinberg School of Medicine; S.T. Sredni, MD, PhD, Research Assistant Professor, Pediatric Neurosurgery, Northwestern University Feinberg School of Medicine; L.M. Pachman, MD, Professor of Pediatrics, Stanley Manne Children’s Research Institute, and Cure JM Center of Excellence in JM Research and Care, and Department of Pediatrics, Division of Rheumatology, Northwestern University Feinberg School of Medicine. Address correspondence to Dr. L.M. Pachman, Stanley Manne Children’s Research Institute, Department of Pediatrics, 225 East Chicago Ave., Box 212, Chicago, Illinois 60611, USA. E-mail: pachman@northwestern.edu. Accepted for publication August 17, 2015.
In this issue
The Journal of Rheumatology
Vol. 51, Issue 3
1 Mar 2024
MicroRNA-10a Regulation of Proinflammatory Mediators: An Important Component of Untreated Juvenile Dermatomyositis
Dong Xu, Chiang-Ching Huang, Akadia Kachaochana, Gabrielle A. Morgan, Maria F. Bonaldo, Marcelo B. Soares, Fabricio Costa, John Sarwark, Simone T. Sredni, Lauren M. Pachman
The Journal of Rheumatology Dec 2015, jrheum.141474; DOI: 10.3899/jrheum.141474
MicroRNA-10a Regulation of Proinflammatory Mediators: An Important Component of Untreated Juvenile Dermatomyositis
Dong Xu, Chiang-Ching Huang, Akadia Kachaochana, Gabrielle A. Morgan, Maria F. Bonaldo, Marcelo B. Soares, Fabricio Costa, John Sarwark, Simone T. Sredni, Lauren M. Pachman
The Journal of Rheumatology Dec 2015, jrheum.141474; DOI: 10.3899/jrheum.141474