Research ArticleArticle
Vasoactive Therapy in Systemic Sclerosis: Real-life Therapeutic Practice in More Than 3000 Patients
Pia Moinzadeh, Gabriela Riemekasten, Elise Siegert, Gerhard Fierlbeck, Joerg Henes, Norbert Blank, Inga Melchers, Ulf Mueller-Ladner, Marc Frerix, Alexander Kreuter, Christian Tigges, Nina Lahner, Laura Susok, Claudia Guenther, Gabriele Zeidler, Christiane Pfeiffer, Margitta Worm, Sigrid Karrer, Elisabeth Aberer, Agnes Bretterklieber, Ekkehard Genth, Jan C. Simon, Joerg H.W. Distler, Ruediger Hein, Matthias Schneider, Cornelia S. Seitz, Claudia Herink, Kerstin Steinbrink, Miklos Sárdy, Rita Varga, Hartwig Mensing, Christian Mensing, Percy Lehmann, Gunther Neeck, Christoph Fiehn, Manfred Weber, Matthias Goebeler, Harald Burkhardt, Michael Buslau, Keihan Ahmadi-Simab, Andrea Himsel, Aaron Juche, Ina Koetter, Annegret Kuhn, Michael Sticherling, Martin Hellmich, Kathrin Kuhr, Thomas Krieg, Jan Ehrchen, Cord Sunderkoetter and Nicolas Hunzelmann
The Journal of Rheumatology November 2015, jrheum.150382; DOI: https://doi.org/10.3899/jrheum.150382
Pia Moinzadeh
From the Department of Dermatology, University Hospital of Cologne; Department of Internal Medicine, Hospital of Cologne Merheim; Institute of Medical Statistics, Informatics and Epidemiology, University of Cologne, Cologne; Department of Rheumatology, University Medical Center Schleswig-Holstein, Lübeck; Department of Rheumatology and Clinical Immunology, and Department of Dermatology, University of Berlin, Charité, Berlin; Department of Rheumatology, Immanuel Hospital, Berlin-Buch; Department of Dermatology, and Department of Rheumatology, University Hospital Tübingen, Tübingen; Department of Internal Medicine, Division of Rheumatology, Heidelberg University Hospital; Division of Immunogenetics, German Cancer Research Center, Heidelberg; Department of Rheumatology and Clinical Immunology, University Medical Center, Freiburg; Department of Rheumatology and Clinical Immunology, University of Giessen, Kerckhoff Clinic, Bad Nauheim; Department of Dermatology, HELIOS St. Elisabeth Clinic, Oberhausen; Department of Dermatology, St. Joseph Hospital, Ruhr- University of Bochum, Bochum; Department of Dermatology, University Hospital Carl Gustav Carus, Dresden; Department of Rheumatology, Johanniter-Hospital, Treuenbrietzen; Department of Dermatology, Ulm University Hospital, Ulm; Department of Dermatology, University Hospital Regensburg, Regensburg; Department of Rheumatology, Clinic of Rheumatology of Aachen, Aachen; Department of Dermatology, University Hospital Leipzig, Leipzig; Department of Rheumatology, and Department of Dermatology, University Hospital Erlangen, Erlangen; Department of Dermatology, TUM University Hospital; Department of Dermatology, Ludwig Maximilian University, Munich; Department of Rheumatology and Nephrology, University Hospital Duesseldorf, Duesseldorf; Department of Dermatology, University Hospital Göttingen, Göttingen; Department of Dermatology, University Medical Center, Johannes Gutenberg University, Mainz; Clinic for Dermatology, Hamburg Alstertal; Department of Dermatology, Helios Clinic, Wuppertal; Center for Rheumatology Bad Doberan, Bad Doberan; Center for Rheumatology Acura, Baden-Baden; Department of Dermatology, University Hospital of Würzburg, Würzburg; Department of Rheumatology, University Hospital Frankfurt, Frankfurt; Center for Rheumatology (Rehabilitation), Rheinfelden; Clinic for Internal Medicine, Klinikum Stephansplatz; Department of Rheumatology, Asklepios Clinic Altona, Hamburg; Department of Rheumatology, GRP-Hospital Ruesselheim, Darmstadt; Department of Dermatology and Venereology, University Hospital Muenster, Muenster, Germany; Department of Dermatology, Medical University of Graz, Graz, Austria. Supported by a grant of the German Federal Ministry of Education and Research (BMBF; 01GM0310 NH, TK; 01GM0631 CS) and the Edith Busch Foundation. The work of Pia Moinzadeh was supported by “Koeln Fortune” (155/2014) and “Deutsche Stiftung Sklerodermie” (3649/0096/31) grants. P. Moinzadeh, MD, Department of Dermatology, University Hospital of Cologne; G. Riemekasten, MD, Department of Rheumatology, University Medical Center Schleswig-Holstein; E. Siegert, Department of Rheumatology and Clinical Immunology, University of Berlin, Charité; G. Fierlbeck, MD, Department of Dermatology, University Hospital Tübingen; J. Henes, MD, Department of Rheumatology, University Hospital Tübingen; N. Blank, MD, Department of Internal Medicine, Division of Rheumatology, Heidelberg University Hospital; I. Melchers, MD, Department of Rheumatology and Clinical Immunology, University Medical Center; U. Mueller-Ladner, MD, Department of Rheumatology and Clinical Immunology, University of Giessen, Kerckhoff Clinic; M. Frerix, MD, Department of Rheumatology and Clinical Immunology, University of Giessen, Kerckhoff Clinic; A. Kreuter, MD, Department of Dermatology, HELIOS St. Elisabeth Clinic; C. Tigges, MD, Department of Dermatology, HELIOS St. Elisabeth Clinic; N. Lahner, MD, Department of Dermatology, St. Joseph Hospital, Ruhr-University of Bochum; L. Susok, MD, Department of Dermatology, St. Joseph Hospital, Ruhr-University of Bochum; C. Guenther, MD, Department of Dermatology, University Hospital Carl Gustav Carus; G. Zeidler, MD, Department of Rheumatology, Johanniter-Hospital; C. Pfeiffer, MD, Department of Dermatology, Ulm University Hospital; M. Worm, MD, Department of Dermatology, University of Berlin, Charité; S. Karrer, MD, Department of Dermatology, University Hospital Regensburg; E. Aberer, MD, Department of Dermatology, Medical University of Graz; A. Bretterklieber, MD, Department of Dermatology, Medical University of Graz; E. Genth, MD, Department of Rheumatology, Clinic of Rheumatology of Aachen; J.C. Simon, MD, Department of Dermatology, University Hospital Leipzig; J.H. Distler, MD, Department of Rheumatology, University Hospital Erlangen; R. Hein, MD, Department of Dermatology, TUM University Hospital; M. Schneider, MD, Department of Rheumatology and Nephrology, University Hospital Duesseldorf; C.S. Seitz, MD, Department of Dermatology, University Hospital Göttingen; C. Herink, MD, Department of Dermatology, University Hospital Göttingen; K. Steinbrink, MD, Department of Dermatology, University Medical Center, Johannes Gutenberg University; M. Sárdy, MD, Department of Dermatology, Ludwig Maximilian University; R. Varga, MD, Department of Dermatology, Ludwig Maximilian University; H. Mensing, MD, Clinic for Dermatology; C. Mensing, MD, Clinic for Dermatology; P. Lehmann, MD, Department of Dermatology, Helios Clinic; G. Neeck, MD, Center for Rheumatology Bad Doberan; C. Fiehn, MD, Center for Rheumatology Acura; M. Weber, MD, Department of Internal Medicine, Hospital of Cologne Merheim; M. Goebeler, MD, Department of Dermatology, University Hospital of Würzburg; H. Burkhardt, MD, Department of Rheumatology, University Hospital Frankfurt; M. Buslau, MD, Center for Rheumatology (Rehabilitation); K. Ahmadi-Simab, MD, Clinic for Internal Medicine, Klinikum Stephansplatz; A. Himsel, MD, Department of Rheumatology, GRP-Hospital Ruesselheim; A. Juche, MD, Department of Rheumatology, Immanuel Hospital; I. Koetter, MD, Department of Rheumatology, Asklepios Clinic Altona; A. Kuhn, MD, Division of Immunogenetics, German Cancer Research Center; M. Sticherling, MD, Department of Dermatology, University Hospital Erlangen; M. Hellmich, MD, Institute of Medical Statistics, Informatics and Epidemiology, University of Cologne; K. Kuhr, MD, Institute of Medical Statistics, Informatics and Epidemiology, University of Cologne; T. Krieg, MD, Department of Dermatology, University Hospital of Cologne; J. Ehrchen, MD, Department of Dermatology and Venereology, University Hospital Muenster; C. Sunderkoetter, MD, Department of Dermatology and Venereology, University Hospital Muenster; N. Hunzelmann, MD, Department of Dermatology, University Hospital of Cologne. Address correspondence to Dr. P. Moinzadeh, Department of Dermatology and Venereology, University of Cologne, Kerpener Str. 62, 50937 Cologne, Germany. E-mail: pia.moinzadeh@uk-koeln.de. Accepted for publication August 28, 2015.
Gabriela Riemekasten
From the Department of Dermatology, University Hospital of Cologne; Department of Internal Medicine, Hospital of Cologne Merheim; Institute of Medical Statistics, Informatics and Epidemiology, University of Cologne, Cologne; Department of Rheumatology, University Medical Center Schleswig-Holstein, Lübeck; Department of Rheumatology and Clinical Immunology, and Department of Dermatology, University of Berlin, Charité, Berlin; Department of Rheumatology, Immanuel Hospital, Berlin-Buch; Department of Dermatology, and Department of Rheumatology, University Hospital Tübingen, Tübingen; Department of Internal Medicine, Division of Rheumatology, Heidelberg University Hospital; Division of Immunogenetics, German Cancer Research Center, Heidelberg; Department of Rheumatology and Clinical Immunology, University Medical Center, Freiburg; Department of Rheumatology and Clinical Immunology, University of Giessen, Kerckhoff Clinic, Bad Nauheim; Department of Dermatology, HELIOS St. Elisabeth Clinic, Oberhausen; Department of Dermatology, St. Joseph Hospital, Ruhr- University of Bochum, Bochum; Department of Dermatology, University Hospital Carl Gustav Carus, Dresden; Department of Rheumatology, Johanniter-Hospital, Treuenbrietzen; Department of Dermatology, Ulm University Hospital, Ulm; Department of Dermatology, University Hospital Regensburg, Regensburg; Department of Rheumatology, Clinic of Rheumatology of Aachen, Aachen; Department of Dermatology, University Hospital Leipzig, Leipzig; Department of Rheumatology, and Department of Dermatology, University Hospital Erlangen, Erlangen; Department of Dermatology, TUM University Hospital; Department of Dermatology, Ludwig Maximilian University, Munich; Department of Rheumatology and Nephrology, University Hospital Duesseldorf, Duesseldorf; Department of Dermatology, University Hospital Göttingen, Göttingen; Department of Dermatology, University Medical Center, Johannes Gutenberg University, Mainz; Clinic for Dermatology, Hamburg Alstertal; Department of Dermatology, Helios Clinic, Wuppertal; Center for Rheumatology Bad Doberan, Bad Doberan; Center for Rheumatology Acura, Baden-Baden; Department of Dermatology, University Hospital of Würzburg, Würzburg; Department of Rheumatology, University Hospital Frankfurt, Frankfurt; Center for Rheumatology (Rehabilitation), Rheinfelden; Clinic for Internal Medicine, Klinikum Stephansplatz; Department of Rheumatology, Asklepios Clinic Altona, Hamburg; Department of Rheumatology, GRP-Hospital Ruesselheim, Darmstadt; Department of Dermatology and Venereology, University Hospital Muenster, Muenster, Germany; Department of Dermatology, Medical University of Graz, Graz, Austria. Supported by a grant of the German Federal Ministry of Education and Research (BMBF; 01GM0310 NH, TK; 01GM0631 CS) and the Edith Busch Foundation. The work of Pia Moinzadeh was supported by “Koeln Fortune” (155/2014) and “Deutsche Stiftung Sklerodermie” (3649/0096/31) grants. P. Moinzadeh, MD, Department of Dermatology, University Hospital of Cologne; G. Riemekasten, MD, Department of Rheumatology, University Medical Center Schleswig-Holstein; E. Siegert, Department of Rheumatology and Clinical Immunology, University of Berlin, Charité; G. Fierlbeck, MD, Department of Dermatology, University Hospital Tübingen; J. Henes, MD, Department of Rheumatology, University Hospital Tübingen; N. Blank, MD, Department of Internal Medicine, Division of Rheumatology, Heidelberg University Hospital; I. Melchers, MD, Department of Rheumatology and Clinical Immunology, University Medical Center; U. Mueller-Ladner, MD, Department of Rheumatology and Clinical Immunology, University of Giessen, Kerckhoff Clinic; M. Frerix, MD, Department of Rheumatology and Clinical Immunology, University of Giessen, Kerckhoff Clinic; A. Kreuter, MD, Department of Dermatology, HELIOS St. Elisabeth Clinic; C. Tigges, MD, Department of Dermatology, HELIOS St. Elisabeth Clinic; N. Lahner, MD, Department of Dermatology, St. Joseph Hospital, Ruhr-University of Bochum; L. Susok, MD, Department of Dermatology, St. Joseph Hospital, Ruhr-University of Bochum; C. Guenther, MD, Department of Dermatology, University Hospital Carl Gustav Carus; G. Zeidler, MD, Department of Rheumatology, Johanniter-Hospital; C. Pfeiffer, MD, Department of Dermatology, Ulm University Hospital; M. Worm, MD, Department of Dermatology, University of Berlin, Charité; S. Karrer, MD, Department of Dermatology, University Hospital Regensburg; E. Aberer, MD, Department of Dermatology, Medical University of Graz; A. Bretterklieber, MD, Department of Dermatology, Medical University of Graz; E. Genth, MD, Department of Rheumatology, Clinic of Rheumatology of Aachen; J.C. Simon, MD, Department of Dermatology, University Hospital Leipzig; J.H. Distler, MD, Department of Rheumatology, University Hospital Erlangen; R. Hein, MD, Department of Dermatology, TUM University Hospital; M. Schneider, MD, Department of Rheumatology and Nephrology, University Hospital Duesseldorf; C.S. Seitz, MD, Department of Dermatology, University Hospital Göttingen; C. Herink, MD, Department of Dermatology, University Hospital Göttingen; K. Steinbrink, MD, Department of Dermatology, University Medical Center, Johannes Gutenberg University; M. Sárdy, MD, Department of Dermatology, Ludwig Maximilian University; R. Varga, MD, Department of Dermatology, Ludwig Maximilian University; H. Mensing, MD, Clinic for Dermatology; C. Mensing, MD, Clinic for Dermatology; P. Lehmann, MD, Department of Dermatology, Helios Clinic; G. Neeck, MD, Center for Rheumatology Bad Doberan; C. Fiehn, MD, Center for Rheumatology Acura; M. Weber, MD, Department of Internal Medicine, Hospital of Cologne Merheim; M. Goebeler, MD, Department of Dermatology, University Hospital of Würzburg; H. Burkhardt, MD, Department of Rheumatology, University Hospital Frankfurt; M. Buslau, MD, Center for Rheumatology (Rehabilitation); K. Ahmadi-Simab, MD, Clinic for Internal Medicine, Klinikum Stephansplatz; A. Himsel, MD, Department of Rheumatology, GRP-Hospital Ruesselheim; A. Juche, MD, Department of Rheumatology, Immanuel Hospital; I. Koetter, MD, Department of Rheumatology, Asklepios Clinic Altona; A. Kuhn, MD, Division of Immunogenetics, German Cancer Research Center; M. Sticherling, MD, Department of Dermatology, University Hospital Erlangen; M. Hellmich, MD, Institute of Medical Statistics, Informatics and Epidemiology, University of Cologne; K. Kuhr, MD, Institute of Medical Statistics, Informatics and Epidemiology, University of Cologne; T. Krieg, MD, Department of Dermatology, University Hospital of Cologne; J. Ehrchen, MD, Department of Dermatology and Venereology, University Hospital Muenster; C. Sunderkoetter, MD, Department of Dermatology and Venereology, University Hospital Muenster; N. Hunzelmann, MD, Department of Dermatology, University Hospital of Cologne. Address correspondence to Dr. P. Moinzadeh, Department of Dermatology and Venereology, University of Cologne, Kerpener Str. 62, 50937 Cologne, Germany. E-mail: pia.moinzadeh@uk-koeln.de. Accepted for publication August 28, 2015.
Elise Siegert
From the Department of Dermatology, University Hospital of Cologne; Department of Internal Medicine, Hospital of Cologne Merheim; Institute of Medical Statistics, Informatics and Epidemiology, University of Cologne, Cologne; Department of Rheumatology, University Medical Center Schleswig-Holstein, Lübeck; Department of Rheumatology and Clinical Immunology, and Department of Dermatology, University of Berlin, Charité, Berlin; Department of Rheumatology, Immanuel Hospital, Berlin-Buch; Department of Dermatology, and Department of Rheumatology, University Hospital Tübingen, Tübingen; Department of Internal Medicine, Division of Rheumatology, Heidelberg University Hospital; Division of Immunogenetics, German Cancer Research Center, Heidelberg; Department of Rheumatology and Clinical Immunology, University Medical Center, Freiburg; Department of Rheumatology and Clinical Immunology, University of Giessen, Kerckhoff Clinic, Bad Nauheim; Department of Dermatology, HELIOS St. Elisabeth Clinic, Oberhausen; Department of Dermatology, St. Joseph Hospital, Ruhr- University of Bochum, Bochum; Department of Dermatology, University Hospital Carl Gustav Carus, Dresden; Department of Rheumatology, Johanniter-Hospital, Treuenbrietzen; Department of Dermatology, Ulm University Hospital, Ulm; Department of Dermatology, University Hospital Regensburg, Regensburg; Department of Rheumatology, Clinic of Rheumatology of Aachen, Aachen; Department of Dermatology, University Hospital Leipzig, Leipzig; Department of Rheumatology, and Department of Dermatology, University Hospital Erlangen, Erlangen; Department of Dermatology, TUM University Hospital; Department of Dermatology, Ludwig Maximilian University, Munich; Department of Rheumatology and Nephrology, University Hospital Duesseldorf, Duesseldorf; Department of Dermatology, University Hospital Göttingen, Göttingen; Department of Dermatology, University Medical Center, Johannes Gutenberg University, Mainz; Clinic for Dermatology, Hamburg Alstertal; Department of Dermatology, Helios Clinic, Wuppertal; Center for Rheumatology Bad Doberan, Bad Doberan; Center for Rheumatology Acura, Baden-Baden; Department of Dermatology, University Hospital of Würzburg, Würzburg; Department of Rheumatology, University Hospital Frankfurt, Frankfurt; Center for Rheumatology (Rehabilitation), Rheinfelden; Clinic for Internal Medicine, Klinikum Stephansplatz; Department of Rheumatology, Asklepios Clinic Altona, Hamburg; Department of Rheumatology, GRP-Hospital Ruesselheim, Darmstadt; Department of Dermatology and Venereology, University Hospital Muenster, Muenster, Germany; Department of Dermatology, Medical University of Graz, Graz, Austria. Supported by a grant of the German Federal Ministry of Education and Research (BMBF; 01GM0310 NH, TK; 01GM0631 CS) and the Edith Busch Foundation. The work of Pia Moinzadeh was supported by “Koeln Fortune” (155/2014) and “Deutsche Stiftung Sklerodermie” (3649/0096/31) grants. P. Moinzadeh, MD, Department of Dermatology, University Hospital of Cologne; G. Riemekasten, MD, Department of Rheumatology, University Medical Center Schleswig-Holstein; E. Siegert, Department of Rheumatology and Clinical Immunology, University of Berlin, Charité; G. Fierlbeck, MD, Department of Dermatology, University Hospital Tübingen; J. Henes, MD, Department of Rheumatology, University Hospital Tübingen; N. Blank, MD, Department of Internal Medicine, Division of Rheumatology, Heidelberg University Hospital; I. Melchers, MD, Department of Rheumatology and Clinical Immunology, University Medical Center; U. Mueller-Ladner, MD, Department of Rheumatology and Clinical Immunology, University of Giessen, Kerckhoff Clinic; M. Frerix, MD, Department of Rheumatology and Clinical Immunology, University of Giessen, Kerckhoff Clinic; A. Kreuter, MD, Department of Dermatology, HELIOS St. Elisabeth Clinic; C. Tigges, MD, Department of Dermatology, HELIOS St. Elisabeth Clinic; N. Lahner, MD, Department of Dermatology, St. Joseph Hospital, Ruhr-University of Bochum; L. Susok, MD, Department of Dermatology, St. Joseph Hospital, Ruhr-University of Bochum; C. Guenther, MD, Department of Dermatology, University Hospital Carl Gustav Carus; G. Zeidler, MD, Department of Rheumatology, Johanniter-Hospital; C. Pfeiffer, MD, Department of Dermatology, Ulm University Hospital; M. Worm, MD, Department of Dermatology, University of Berlin, Charité; S. Karrer, MD, Department of Dermatology, University Hospital Regensburg; E. Aberer, MD, Department of Dermatology, Medical University of Graz; A. Bretterklieber, MD, Department of Dermatology, Medical University of Graz; E. Genth, MD, Department of Rheumatology, Clinic of Rheumatology of Aachen; J.C. Simon, MD, Department of Dermatology, University Hospital Leipzig; J.H. Distler, MD, Department of Rheumatology, University Hospital Erlangen; R. Hein, MD, Department of Dermatology, TUM University Hospital; M. Schneider, MD, Department of Rheumatology and Nephrology, University Hospital Duesseldorf; C.S. Seitz, MD, Department of Dermatology, University Hospital Göttingen; C. Herink, MD, Department of Dermatology, University Hospital Göttingen; K. Steinbrink, MD, Department of Dermatology, University Medical Center, Johannes Gutenberg University; M. Sárdy, MD, Department of Dermatology, Ludwig Maximilian University; R. Varga, MD, Department of Dermatology, Ludwig Maximilian University; H. Mensing, MD, Clinic for Dermatology; C. Mensing, MD, Clinic for Dermatology; P. Lehmann, MD, Department of Dermatology, Helios Clinic; G. Neeck, MD, Center for Rheumatology Bad Doberan; C. Fiehn, MD, Center for Rheumatology Acura; M. Weber, MD, Department of Internal Medicine, Hospital of Cologne Merheim; M. Goebeler, MD, Department of Dermatology, University Hospital of Würzburg; H. Burkhardt, MD, Department of Rheumatology, University Hospital Frankfurt; M. Buslau, MD, Center for Rheumatology (Rehabilitation); K. Ahmadi-Simab, MD, Clinic for Internal Medicine, Klinikum Stephansplatz; A. Himsel, MD, Department of Rheumatology, GRP-Hospital Ruesselheim; A. Juche, MD, Department of Rheumatology, Immanuel Hospital; I. Koetter, MD, Department of Rheumatology, Asklepios Clinic Altona; A. Kuhn, MD, Division of Immunogenetics, German Cancer Research Center; M. Sticherling, MD, Department of Dermatology, University Hospital Erlangen; M. Hellmich, MD, Institute of Medical Statistics, Informatics and Epidemiology, University of Cologne; K. Kuhr, MD, Institute of Medical Statistics, Informatics and Epidemiology, University of Cologne; T. Krieg, MD, Department of Dermatology, University Hospital of Cologne; J. Ehrchen, MD, Department of Dermatology and Venereology, University Hospital Muenster; C. Sunderkoetter, MD, Department of Dermatology and Venereology, University Hospital Muenster; N. Hunzelmann, MD, Department of Dermatology, University Hospital of Cologne. Address correspondence to Dr. P. Moinzadeh, Department of Dermatology and Venereology, University of Cologne, Kerpener Str. 62, 50937 Cologne, Germany. E-mail: pia.moinzadeh@uk-koeln.de. Accepted for publication August 28, 2015.
Gerhard Fierlbeck
From the Department of Dermatology, University Hospital of Cologne; Department of Internal Medicine, Hospital of Cologne Merheim; Institute of Medical Statistics, Informatics and Epidemiology, University of Cologne, Cologne; Department of Rheumatology, University Medical Center Schleswig-Holstein, Lübeck; Department of Rheumatology and Clinical Immunology, and Department of Dermatology, University of Berlin, Charité, Berlin; Department of Rheumatology, Immanuel Hospital, Berlin-Buch; Department of Dermatology, and Department of Rheumatology, University Hospital Tübingen, Tübingen; Department of Internal Medicine, Division of Rheumatology, Heidelberg University Hospital; Division of Immunogenetics, German Cancer Research Center, Heidelberg; Department of Rheumatology and Clinical Immunology, University Medical Center, Freiburg; Department of Rheumatology and Clinical Immunology, University of Giessen, Kerckhoff Clinic, Bad Nauheim; Department of Dermatology, HELIOS St. Elisabeth Clinic, Oberhausen; Department of Dermatology, St. Joseph Hospital, Ruhr- University of Bochum, Bochum; Department of Dermatology, University Hospital Carl Gustav Carus, Dresden; Department of Rheumatology, Johanniter-Hospital, Treuenbrietzen; Department of Dermatology, Ulm University Hospital, Ulm; Department of Dermatology, University Hospital Regensburg, Regensburg; Department of Rheumatology, Clinic of Rheumatology of Aachen, Aachen; Department of Dermatology, University Hospital Leipzig, Leipzig; Department of Rheumatology, and Department of Dermatology, University Hospital Erlangen, Erlangen; Department of Dermatology, TUM University Hospital; Department of Dermatology, Ludwig Maximilian University, Munich; Department of Rheumatology and Nephrology, University Hospital Duesseldorf, Duesseldorf; Department of Dermatology, University Hospital Göttingen, Göttingen; Department of Dermatology, University Medical Center, Johannes Gutenberg University, Mainz; Clinic for Dermatology, Hamburg Alstertal; Department of Dermatology, Helios Clinic, Wuppertal; Center for Rheumatology Bad Doberan, Bad Doberan; Center for Rheumatology Acura, Baden-Baden; Department of Dermatology, University Hospital of Würzburg, Würzburg; Department of Rheumatology, University Hospital Frankfurt, Frankfurt; Center for Rheumatology (Rehabilitation), Rheinfelden; Clinic for Internal Medicine, Klinikum Stephansplatz; Department of Rheumatology, Asklepios Clinic Altona, Hamburg; Department of Rheumatology, GRP-Hospital Ruesselheim, Darmstadt; Department of Dermatology and Venereology, University Hospital Muenster, Muenster, Germany; Department of Dermatology, Medical University of Graz, Graz, Austria. Supported by a grant of the German Federal Ministry of Education and Research (BMBF; 01GM0310 NH, TK; 01GM0631 CS) and the Edith Busch Foundation. The work of Pia Moinzadeh was supported by “Koeln Fortune” (155/2014) and “Deutsche Stiftung Sklerodermie” (3649/0096/31) grants. P. Moinzadeh, MD, Department of Dermatology, University Hospital of Cologne; G. Riemekasten, MD, Department of Rheumatology, University Medical Center Schleswig-Holstein; E. Siegert, Department of Rheumatology and Clinical Immunology, University of Berlin, Charité; G. Fierlbeck, MD, Department of Dermatology, University Hospital Tübingen; J. Henes, MD, Department of Rheumatology, University Hospital Tübingen; N. Blank, MD, Department of Internal Medicine, Division of Rheumatology, Heidelberg University Hospital; I. Melchers, MD, Department of Rheumatology and Clinical Immunology, University Medical Center; U. Mueller-Ladner, MD, Department of Rheumatology and Clinical Immunology, University of Giessen, Kerckhoff Clinic; M. Frerix, MD, Department of Rheumatology and Clinical Immunology, University of Giessen, Kerckhoff Clinic; A. Kreuter, MD, Department of Dermatology, HELIOS St. Elisabeth Clinic; C. Tigges, MD, Department of Dermatology, HELIOS St. Elisabeth Clinic; N. Lahner, MD, Department of Dermatology, St. Joseph Hospital, Ruhr-University of Bochum; L. Susok, MD, Department of Dermatology, St. Joseph Hospital, Ruhr-University of Bochum; C. Guenther, MD, Department of Dermatology, University Hospital Carl Gustav Carus; G. Zeidler, MD, Department of Rheumatology, Johanniter-Hospital; C. Pfeiffer, MD, Department of Dermatology, Ulm University Hospital; M. Worm, MD, Department of Dermatology, University of Berlin, Charité; S. Karrer, MD, Department of Dermatology, University Hospital Regensburg; E. Aberer, MD, Department of Dermatology, Medical University of Graz; A. Bretterklieber, MD, Department of Dermatology, Medical University of Graz; E. Genth, MD, Department of Rheumatology, Clinic of Rheumatology of Aachen; J.C. Simon, MD, Department of Dermatology, University Hospital Leipzig; J.H. Distler, MD, Department of Rheumatology, University Hospital Erlangen; R. Hein, MD, Department of Dermatology, TUM University Hospital; M. Schneider, MD, Department of Rheumatology and Nephrology, University Hospital Duesseldorf; C.S. Seitz, MD, Department of Dermatology, University Hospital Göttingen; C. Herink, MD, Department of Dermatology, University Hospital Göttingen; K. Steinbrink, MD, Department of Dermatology, University Medical Center, Johannes Gutenberg University; M. Sárdy, MD, Department of Dermatology, Ludwig Maximilian University; R. Varga, MD, Department of Dermatology, Ludwig Maximilian University; H. Mensing, MD, Clinic for Dermatology; C. Mensing, MD, Clinic for Dermatology; P. Lehmann, MD, Department of Dermatology, Helios Clinic; G. Neeck, MD, Center for Rheumatology Bad Doberan; C. Fiehn, MD, Center for Rheumatology Acura; M. Weber, MD, Department of Internal Medicine, Hospital of Cologne Merheim; M. Goebeler, MD, Department of Dermatology, University Hospital of Würzburg; H. Burkhardt, MD, Department of Rheumatology, University Hospital Frankfurt; M. Buslau, MD, Center for Rheumatology (Rehabilitation); K. Ahmadi-Simab, MD, Clinic for Internal Medicine, Klinikum Stephansplatz; A. Himsel, MD, Department of Rheumatology, GRP-Hospital Ruesselheim; A. Juche, MD, Department of Rheumatology, Immanuel Hospital; I. Koetter, MD, Department of Rheumatology, Asklepios Clinic Altona; A. Kuhn, MD, Division of Immunogenetics, German Cancer Research Center; M. Sticherling, MD, Department of Dermatology, University Hospital Erlangen; M. Hellmich, MD, Institute of Medical Statistics, Informatics and Epidemiology, University of Cologne; K. Kuhr, MD, Institute of Medical Statistics, Informatics and Epidemiology, University of Cologne; T. Krieg, MD, Department of Dermatology, University Hospital of Cologne; J. Ehrchen, MD, Department of Dermatology and Venereology, University Hospital Muenster; C. Sunderkoetter, MD, Department of Dermatology and Venereology, University Hospital Muenster; N. Hunzelmann, MD, Department of Dermatology, University Hospital of Cologne. Address correspondence to Dr. P. Moinzadeh, Department of Dermatology and Venereology, University of Cologne, Kerpener Str. 62, 50937 Cologne, Germany. E-mail: pia.moinzadeh@uk-koeln.de. Accepted for publication August 28, 2015.
Joerg Henes
From the Department of Dermatology, University Hospital of Cologne; Department of Internal Medicine, Hospital of Cologne Merheim; Institute of Medical Statistics, Informatics and Epidemiology, University of Cologne, Cologne; Department of Rheumatology, University Medical Center Schleswig-Holstein, Lübeck; Department of Rheumatology and Clinical Immunology, and Department of Dermatology, University of Berlin, Charité, Berlin; Department of Rheumatology, Immanuel Hospital, Berlin-Buch; Department of Dermatology, and Department of Rheumatology, University Hospital Tübingen, Tübingen; Department of Internal Medicine, Division of Rheumatology, Heidelberg University Hospital; Division of Immunogenetics, German Cancer Research Center, Heidelberg; Department of Rheumatology and Clinical Immunology, University Medical Center, Freiburg; Department of Rheumatology and Clinical Immunology, University of Giessen, Kerckhoff Clinic, Bad Nauheim; Department of Dermatology, HELIOS St. Elisabeth Clinic, Oberhausen; Department of Dermatology, St. Joseph Hospital, Ruhr- University of Bochum, Bochum; Department of Dermatology, University Hospital Carl Gustav Carus, Dresden; Department of Rheumatology, Johanniter-Hospital, Treuenbrietzen; Department of Dermatology, Ulm University Hospital, Ulm; Department of Dermatology, University Hospital Regensburg, Regensburg; Department of Rheumatology, Clinic of Rheumatology of Aachen, Aachen; Department of Dermatology, University Hospital Leipzig, Leipzig; Department of Rheumatology, and Department of Dermatology, University Hospital Erlangen, Erlangen; Department of Dermatology, TUM University Hospital; Department of Dermatology, Ludwig Maximilian University, Munich; Department of Rheumatology and Nephrology, University Hospital Duesseldorf, Duesseldorf; Department of Dermatology, University Hospital Göttingen, Göttingen; Department of Dermatology, University Medical Center, Johannes Gutenberg University, Mainz; Clinic for Dermatology, Hamburg Alstertal; Department of Dermatology, Helios Clinic, Wuppertal; Center for Rheumatology Bad Doberan, Bad Doberan; Center for Rheumatology Acura, Baden-Baden; Department of Dermatology, University Hospital of Würzburg, Würzburg; Department of Rheumatology, University Hospital Frankfurt, Frankfurt; Center for Rheumatology (Rehabilitation), Rheinfelden; Clinic for Internal Medicine, Klinikum Stephansplatz; Department of Rheumatology, Asklepios Clinic Altona, Hamburg; Department of Rheumatology, GRP-Hospital Ruesselheim, Darmstadt; Department of Dermatology and Venereology, University Hospital Muenster, Muenster, Germany; Department of Dermatology, Medical University of Graz, Graz, Austria. Supported by a grant of the German Federal Ministry of Education and Research (BMBF; 01GM0310 NH, TK; 01GM0631 CS) and the Edith Busch Foundation. The work of Pia Moinzadeh was supported by “Koeln Fortune” (155/2014) and “Deutsche Stiftung Sklerodermie” (3649/0096/31) grants. P. Moinzadeh, MD, Department of Dermatology, University Hospital of Cologne; G. Riemekasten, MD, Department of Rheumatology, University Medical Center Schleswig-Holstein; E. Siegert, Department of Rheumatology and Clinical Immunology, University of Berlin, Charité; G. Fierlbeck, MD, Department of Dermatology, University Hospital Tübingen; J. Henes, MD, Department of Rheumatology, University Hospital Tübingen; N. Blank, MD, Department of Internal Medicine, Division of Rheumatology, Heidelberg University Hospital; I. Melchers, MD, Department of Rheumatology and Clinical Immunology, University Medical Center; U. Mueller-Ladner, MD, Department of Rheumatology and Clinical Immunology, University of Giessen, Kerckhoff Clinic; M. Frerix, MD, Department of Rheumatology and Clinical Immunology, University of Giessen, Kerckhoff Clinic; A. Kreuter, MD, Department of Dermatology, HELIOS St. Elisabeth Clinic; C. Tigges, MD, Department of Dermatology, HELIOS St. Elisabeth Clinic; N. Lahner, MD, Department of Dermatology, St. Joseph Hospital, Ruhr-University of Bochum; L. Susok, MD, Department of Dermatology, St. Joseph Hospital, Ruhr-University of Bochum; C. Guenther, MD, Department of Dermatology, University Hospital Carl Gustav Carus; G. Zeidler, MD, Department of Rheumatology, Johanniter-Hospital; C. Pfeiffer, MD, Department of Dermatology, Ulm University Hospital; M. Worm, MD, Department of Dermatology, University of Berlin, Charité; S. Karrer, MD, Department of Dermatology, University Hospital Regensburg; E. Aberer, MD, Department of Dermatology, Medical University of Graz; A. Bretterklieber, MD, Department of Dermatology, Medical University of Graz; E. Genth, MD, Department of Rheumatology, Clinic of Rheumatology of Aachen; J.C. Simon, MD, Department of Dermatology, University Hospital Leipzig; J.H. Distler, MD, Department of Rheumatology, University Hospital Erlangen; R. Hein, MD, Department of Dermatology, TUM University Hospital; M. Schneider, MD, Department of Rheumatology and Nephrology, University Hospital Duesseldorf; C.S. Seitz, MD, Department of Dermatology, University Hospital Göttingen; C. Herink, MD, Department of Dermatology, University Hospital Göttingen; K. Steinbrink, MD, Department of Dermatology, University Medical Center, Johannes Gutenberg University; M. Sárdy, MD, Department of Dermatology, Ludwig Maximilian University; R. Varga, MD, Department of Dermatology, Ludwig Maximilian University; H. Mensing, MD, Clinic for Dermatology; C. Mensing, MD, Clinic for Dermatology; P. Lehmann, MD, Department of Dermatology, Helios Clinic; G. Neeck, MD, Center for Rheumatology Bad Doberan; C. Fiehn, MD, Center for Rheumatology Acura; M. Weber, MD, Department of Internal Medicine, Hospital of Cologne Merheim; M. Goebeler, MD, Department of Dermatology, University Hospital of Würzburg; H. Burkhardt, MD, Department of Rheumatology, University Hospital Frankfurt; M. Buslau, MD, Center for Rheumatology (Rehabilitation); K. Ahmadi-Simab, MD, Clinic for Internal Medicine, Klinikum Stephansplatz; A. Himsel, MD, Department of Rheumatology, GRP-Hospital Ruesselheim; A. Juche, MD, Department of Rheumatology, Immanuel Hospital; I. Koetter, MD, Department of Rheumatology, Asklepios Clinic Altona; A. Kuhn, MD, Division of Immunogenetics, German Cancer Research Center; M. Sticherling, MD, Department of Dermatology, University Hospital Erlangen; M. Hellmich, MD, Institute of Medical Statistics, Informatics and Epidemiology, University of Cologne; K. Kuhr, MD, Institute of Medical Statistics, Informatics and Epidemiology, University of Cologne; T. Krieg, MD, Department of Dermatology, University Hospital of Cologne; J. Ehrchen, MD, Department of Dermatology and Venereology, University Hospital Muenster; C. Sunderkoetter, MD, Department of Dermatology and Venereology, University Hospital Muenster; N. Hunzelmann, MD, Department of Dermatology, University Hospital of Cologne. Address correspondence to Dr. P. Moinzadeh, Department of Dermatology and Venereology, University of Cologne, Kerpener Str. 62, 50937 Cologne, Germany. E-mail: pia.moinzadeh@uk-koeln.de. Accepted for publication August 28, 2015.
Norbert Blank
From the Department of Dermatology, University Hospital of Cologne; Department of Internal Medicine, Hospital of Cologne Merheim; Institute of Medical Statistics, Informatics and Epidemiology, University of Cologne, Cologne; Department of Rheumatology, University Medical Center Schleswig-Holstein, Lübeck; Department of Rheumatology and Clinical Immunology, and Department of Dermatology, University of Berlin, Charité, Berlin; Department of Rheumatology, Immanuel Hospital, Berlin-Buch; Department of Dermatology, and Department of Rheumatology, University Hospital Tübingen, Tübingen; Department of Internal Medicine, Division of Rheumatology, Heidelberg University Hospital; Division of Immunogenetics, German Cancer Research Center, Heidelberg; Department of Rheumatology and Clinical Immunology, University Medical Center, Freiburg; Department of Rheumatology and Clinical Immunology, University of Giessen, Kerckhoff Clinic, Bad Nauheim; Department of Dermatology, HELIOS St. Elisabeth Clinic, Oberhausen; Department of Dermatology, St. Joseph Hospital, Ruhr- University of Bochum, Bochum; Department of Dermatology, University Hospital Carl Gustav Carus, Dresden; Department of Rheumatology, Johanniter-Hospital, Treuenbrietzen; Department of Dermatology, Ulm University Hospital, Ulm; Department of Dermatology, University Hospital Regensburg, Regensburg; Department of Rheumatology, Clinic of Rheumatology of Aachen, Aachen; Department of Dermatology, University Hospital Leipzig, Leipzig; Department of Rheumatology, and Department of Dermatology, University Hospital Erlangen, Erlangen; Department of Dermatology, TUM University Hospital; Department of Dermatology, Ludwig Maximilian University, Munich; Department of Rheumatology and Nephrology, University Hospital Duesseldorf, Duesseldorf; Department of Dermatology, University Hospital Göttingen, Göttingen; Department of Dermatology, University Medical Center, Johannes Gutenberg University, Mainz; Clinic for Dermatology, Hamburg Alstertal; Department of Dermatology, Helios Clinic, Wuppertal; Center for Rheumatology Bad Doberan, Bad Doberan; Center for Rheumatology Acura, Baden-Baden; Department of Dermatology, University Hospital of Würzburg, Würzburg; Department of Rheumatology, University Hospital Frankfurt, Frankfurt; Center for Rheumatology (Rehabilitation), Rheinfelden; Clinic for Internal Medicine, Klinikum Stephansplatz; Department of Rheumatology, Asklepios Clinic Altona, Hamburg; Department of Rheumatology, GRP-Hospital Ruesselheim, Darmstadt; Department of Dermatology and Venereology, University Hospital Muenster, Muenster, Germany; Department of Dermatology, Medical University of Graz, Graz, Austria. Supported by a grant of the German Federal Ministry of Education and Research (BMBF; 01GM0310 NH, TK; 01GM0631 CS) and the Edith Busch Foundation. The work of Pia Moinzadeh was supported by “Koeln Fortune” (155/2014) and “Deutsche Stiftung Sklerodermie” (3649/0096/31) grants. P. Moinzadeh, MD, Department of Dermatology, University Hospital of Cologne; G. Riemekasten, MD, Department of Rheumatology, University Medical Center Schleswig-Holstein; E. Siegert, Department of Rheumatology and Clinical Immunology, University of Berlin, Charité; G. Fierlbeck, MD, Department of Dermatology, University Hospital Tübingen; J. Henes, MD, Department of Rheumatology, University Hospital Tübingen; N. Blank, MD, Department of Internal Medicine, Division of Rheumatology, Heidelberg University Hospital; I. Melchers, MD, Department of Rheumatology and Clinical Immunology, University Medical Center; U. Mueller-Ladner, MD, Department of Rheumatology and Clinical Immunology, University of Giessen, Kerckhoff Clinic; M. Frerix, MD, Department of Rheumatology and Clinical Immunology, University of Giessen, Kerckhoff Clinic; A. Kreuter, MD, Department of Dermatology, HELIOS St. Elisabeth Clinic; C. Tigges, MD, Department of Dermatology, HELIOS St. Elisabeth Clinic; N. Lahner, MD, Department of Dermatology, St. Joseph Hospital, Ruhr-University of Bochum; L. Susok, MD, Department of Dermatology, St. Joseph Hospital, Ruhr-University of Bochum; C. Guenther, MD, Department of Dermatology, University Hospital Carl Gustav Carus; G. Zeidler, MD, Department of Rheumatology, Johanniter-Hospital; C. Pfeiffer, MD, Department of Dermatology, Ulm University Hospital; M. Worm, MD, Department of Dermatology, University of Berlin, Charité; S. Karrer, MD, Department of Dermatology, University Hospital Regensburg; E. Aberer, MD, Department of Dermatology, Medical University of Graz; A. Bretterklieber, MD, Department of Dermatology, Medical University of Graz; E. Genth, MD, Department of Rheumatology, Clinic of Rheumatology of Aachen; J.C. Simon, MD, Department of Dermatology, University Hospital Leipzig; J.H. Distler, MD, Department of Rheumatology, University Hospital Erlangen; R. Hein, MD, Department of Dermatology, TUM University Hospital; M. Schneider, MD, Department of Rheumatology and Nephrology, University Hospital Duesseldorf; C.S. Seitz, MD, Department of Dermatology, University Hospital Göttingen; C. Herink, MD, Department of Dermatology, University Hospital Göttingen; K. Steinbrink, MD, Department of Dermatology, University Medical Center, Johannes Gutenberg University; M. Sárdy, MD, Department of Dermatology, Ludwig Maximilian University; R. Varga, MD, Department of Dermatology, Ludwig Maximilian University; H. Mensing, MD, Clinic for Dermatology; C. Mensing, MD, Clinic for Dermatology; P. Lehmann, MD, Department of Dermatology, Helios Clinic; G. Neeck, MD, Center for Rheumatology Bad Doberan; C. Fiehn, MD, Center for Rheumatology Acura; M. Weber, MD, Department of Internal Medicine, Hospital of Cologne Merheim; M. Goebeler, MD, Department of Dermatology, University Hospital of Würzburg; H. Burkhardt, MD, Department of Rheumatology, University Hospital Frankfurt; M. Buslau, MD, Center for Rheumatology (Rehabilitation); K. Ahmadi-Simab, MD, Clinic for Internal Medicine, Klinikum Stephansplatz; A. Himsel, MD, Department of Rheumatology, GRP-Hospital Ruesselheim; A. Juche, MD, Department of Rheumatology, Immanuel Hospital; I. Koetter, MD, Department of Rheumatology, Asklepios Clinic Altona; A. Kuhn, MD, Division of Immunogenetics, German Cancer Research Center; M. Sticherling, MD, Department of Dermatology, University Hospital Erlangen; M. Hellmich, MD, Institute of Medical Statistics, Informatics and Epidemiology, University of Cologne; K. Kuhr, MD, Institute of Medical Statistics, Informatics and Epidemiology, University of Cologne; T. Krieg, MD, Department of Dermatology, University Hospital of Cologne; J. Ehrchen, MD, Department of Dermatology and Venereology, University Hospital Muenster; C. Sunderkoetter, MD, Department of Dermatology and Venereology, University Hospital Muenster; N. Hunzelmann, MD, Department of Dermatology, University Hospital of Cologne. Address correspondence to Dr. P. Moinzadeh, Department of Dermatology and Venereology, University of Cologne, Kerpener Str. 62, 50937 Cologne, Germany. E-mail: pia.moinzadeh@uk-koeln.de. Accepted for publication August 28, 2015.
Inga Melchers
From the Department of Dermatology, University Hospital of Cologne; Department of Internal Medicine, Hospital of Cologne Merheim; Institute of Medical Statistics, Informatics and Epidemiology, University of Cologne, Cologne; Department of Rheumatology, University Medical Center Schleswig-Holstein, Lübeck; Department of Rheumatology and Clinical Immunology, and Department of Dermatology, University of Berlin, Charité, Berlin; Department of Rheumatology, Immanuel Hospital, Berlin-Buch; Department of Dermatology, and Department of Rheumatology, University Hospital Tübingen, Tübingen; Department of Internal Medicine, Division of Rheumatology, Heidelberg University Hospital; Division of Immunogenetics, German Cancer Research Center, Heidelberg; Department of Rheumatology and Clinical Immunology, University Medical Center, Freiburg; Department of Rheumatology and Clinical Immunology, University of Giessen, Kerckhoff Clinic, Bad Nauheim; Department of Dermatology, HELIOS St. Elisabeth Clinic, Oberhausen; Department of Dermatology, St. Joseph Hospital, Ruhr- University of Bochum, Bochum; Department of Dermatology, University Hospital Carl Gustav Carus, Dresden; Department of Rheumatology, Johanniter-Hospital, Treuenbrietzen; Department of Dermatology, Ulm University Hospital, Ulm; Department of Dermatology, University Hospital Regensburg, Regensburg; Department of Rheumatology, Clinic of Rheumatology of Aachen, Aachen; Department of Dermatology, University Hospital Leipzig, Leipzig; Department of Rheumatology, and Department of Dermatology, University Hospital Erlangen, Erlangen; Department of Dermatology, TUM University Hospital; Department of Dermatology, Ludwig Maximilian University, Munich; Department of Rheumatology and Nephrology, University Hospital Duesseldorf, Duesseldorf; Department of Dermatology, University Hospital Göttingen, Göttingen; Department of Dermatology, University Medical Center, Johannes Gutenberg University, Mainz; Clinic for Dermatology, Hamburg Alstertal; Department of Dermatology, Helios Clinic, Wuppertal; Center for Rheumatology Bad Doberan, Bad Doberan; Center for Rheumatology Acura, Baden-Baden; Department of Dermatology, University Hospital of Würzburg, Würzburg; Department of Rheumatology, University Hospital Frankfurt, Frankfurt; Center for Rheumatology (Rehabilitation), Rheinfelden; Clinic for Internal Medicine, Klinikum Stephansplatz; Department of Rheumatology, Asklepios Clinic Altona, Hamburg; Department of Rheumatology, GRP-Hospital Ruesselheim, Darmstadt; Department of Dermatology and Venereology, University Hospital Muenster, Muenster, Germany; Department of Dermatology, Medical University of Graz, Graz, Austria. Supported by a grant of the German Federal Ministry of Education and Research (BMBF; 01GM0310 NH, TK; 01GM0631 CS) and the Edith Busch Foundation. The work of Pia Moinzadeh was supported by “Koeln Fortune” (155/2014) and “Deutsche Stiftung Sklerodermie” (3649/0096/31) grants. P. Moinzadeh, MD, Department of Dermatology, University Hospital of Cologne; G. Riemekasten, MD, Department of Rheumatology, University Medical Center Schleswig-Holstein; E. Siegert, Department of Rheumatology and Clinical Immunology, University of Berlin, Charité; G. Fierlbeck, MD, Department of Dermatology, University Hospital Tübingen; J. Henes, MD, Department of Rheumatology, University Hospital Tübingen; N. Blank, MD, Department of Internal Medicine, Division of Rheumatology, Heidelberg University Hospital; I. Melchers, MD, Department of Rheumatology and Clinical Immunology, University Medical Center; U. Mueller-Ladner, MD, Department of Rheumatology and Clinical Immunology, University of Giessen, Kerckhoff Clinic; M. Frerix, MD, Department of Rheumatology and Clinical Immunology, University of Giessen, Kerckhoff Clinic; A. Kreuter, MD, Department of Dermatology, HELIOS St. Elisabeth Clinic; C. Tigges, MD, Department of Dermatology, HELIOS St. Elisabeth Clinic; N. Lahner, MD, Department of Dermatology, St. Joseph Hospital, Ruhr-University of Bochum; L. Susok, MD, Department of Dermatology, St. Joseph Hospital, Ruhr-University of Bochum; C. Guenther, MD, Department of Dermatology, University Hospital Carl Gustav Carus; G. Zeidler, MD, Department of Rheumatology, Johanniter-Hospital; C. Pfeiffer, MD, Department of Dermatology, Ulm University Hospital; M. Worm, MD, Department of Dermatology, University of Berlin, Charité; S. Karrer, MD, Department of Dermatology, University Hospital Regensburg; E. Aberer, MD, Department of Dermatology, Medical University of Graz; A. Bretterklieber, MD, Department of Dermatology, Medical University of Graz; E. Genth, MD, Department of Rheumatology, Clinic of Rheumatology of Aachen; J.C. Simon, MD, Department of Dermatology, University Hospital Leipzig; J.H. Distler, MD, Department of Rheumatology, University Hospital Erlangen; R. Hein, MD, Department of Dermatology, TUM University Hospital; M. Schneider, MD, Department of Rheumatology and Nephrology, University Hospital Duesseldorf; C.S. Seitz, MD, Department of Dermatology, University Hospital Göttingen; C. Herink, MD, Department of Dermatology, University Hospital Göttingen; K. Steinbrink, MD, Department of Dermatology, University Medical Center, Johannes Gutenberg University; M. Sárdy, MD, Department of Dermatology, Ludwig Maximilian University; R. Varga, MD, Department of Dermatology, Ludwig Maximilian University; H. Mensing, MD, Clinic for Dermatology; C. Mensing, MD, Clinic for Dermatology; P. Lehmann, MD, Department of Dermatology, Helios Clinic; G. Neeck, MD, Center for Rheumatology Bad Doberan; C. Fiehn, MD, Center for Rheumatology Acura; M. Weber, MD, Department of Internal Medicine, Hospital of Cologne Merheim; M. Goebeler, MD, Department of Dermatology, University Hospital of Würzburg; H. Burkhardt, MD, Department of Rheumatology, University Hospital Frankfurt; M. Buslau, MD, Center for Rheumatology (Rehabilitation); K. Ahmadi-Simab, MD, Clinic for Internal Medicine, Klinikum Stephansplatz; A. Himsel, MD, Department of Rheumatology, GRP-Hospital Ruesselheim; A. Juche, MD, Department of Rheumatology, Immanuel Hospital; I. Koetter, MD, Department of Rheumatology, Asklepios Clinic Altona; A. Kuhn, MD, Division of Immunogenetics, German Cancer Research Center; M. Sticherling, MD, Department of Dermatology, University Hospital Erlangen; M. Hellmich, MD, Institute of Medical Statistics, Informatics and Epidemiology, University of Cologne; K. Kuhr, MD, Institute of Medical Statistics, Informatics and Epidemiology, University of Cologne; T. Krieg, MD, Department of Dermatology, University Hospital of Cologne; J. Ehrchen, MD, Department of Dermatology and Venereology, University Hospital Muenster; C. Sunderkoetter, MD, Department of Dermatology and Venereology, University Hospital Muenster; N. Hunzelmann, MD, Department of Dermatology, University Hospital of Cologne. Address correspondence to Dr. P. Moinzadeh, Department of Dermatology and Venereology, University of Cologne, Kerpener Str. 62, 50937 Cologne, Germany. E-mail: pia.moinzadeh@uk-koeln.de. Accepted for publication August 28, 2015.
Ulf Mueller-Ladner
From the Department of Dermatology, University Hospital of Cologne; Department of Internal Medicine, Hospital of Cologne Merheim; Institute of Medical Statistics, Informatics and Epidemiology, University of Cologne, Cologne; Department of Rheumatology, University Medical Center Schleswig-Holstein, Lübeck; Department of Rheumatology and Clinical Immunology, and Department of Dermatology, University of Berlin, Charité, Berlin; Department of Rheumatology, Immanuel Hospital, Berlin-Buch; Department of Dermatology, and Department of Rheumatology, University Hospital Tübingen, Tübingen; Department of Internal Medicine, Division of Rheumatology, Heidelberg University Hospital; Division of Immunogenetics, German Cancer Research Center, Heidelberg; Department of Rheumatology and Clinical Immunology, University Medical Center, Freiburg; Department of Rheumatology and Clinical Immunology, University of Giessen, Kerckhoff Clinic, Bad Nauheim; Department of Dermatology, HELIOS St. Elisabeth Clinic, Oberhausen; Department of Dermatology, St. Joseph Hospital, Ruhr- University of Bochum, Bochum; Department of Dermatology, University Hospital Carl Gustav Carus, Dresden; Department of Rheumatology, Johanniter-Hospital, Treuenbrietzen; Department of Dermatology, Ulm University Hospital, Ulm; Department of Dermatology, University Hospital Regensburg, Regensburg; Department of Rheumatology, Clinic of Rheumatology of Aachen, Aachen; Department of Dermatology, University Hospital Leipzig, Leipzig; Department of Rheumatology, and Department of Dermatology, University Hospital Erlangen, Erlangen; Department of Dermatology, TUM University Hospital; Department of Dermatology, Ludwig Maximilian University, Munich; Department of Rheumatology and Nephrology, University Hospital Duesseldorf, Duesseldorf; Department of Dermatology, University Hospital Göttingen, Göttingen; Department of Dermatology, University Medical Center, Johannes Gutenberg University, Mainz; Clinic for Dermatology, Hamburg Alstertal; Department of Dermatology, Helios Clinic, Wuppertal; Center for Rheumatology Bad Doberan, Bad Doberan; Center for Rheumatology Acura, Baden-Baden; Department of Dermatology, University Hospital of Würzburg, Würzburg; Department of Rheumatology, University Hospital Frankfurt, Frankfurt; Center for Rheumatology (Rehabilitation), Rheinfelden; Clinic for Internal Medicine, Klinikum Stephansplatz; Department of Rheumatology, Asklepios Clinic Altona, Hamburg; Department of Rheumatology, GRP-Hospital Ruesselheim, Darmstadt; Department of Dermatology and Venereology, University Hospital Muenster, Muenster, Germany; Department of Dermatology, Medical University of Graz, Graz, Austria. Supported by a grant of the German Federal Ministry of Education and Research (BMBF; 01GM0310 NH, TK; 01GM0631 CS) and the Edith Busch Foundation. The work of Pia Moinzadeh was supported by “Koeln Fortune” (155/2014) and “Deutsche Stiftung Sklerodermie” (3649/0096/31) grants. P. Moinzadeh, MD, Department of Dermatology, University Hospital of Cologne; G. Riemekasten, MD, Department of Rheumatology, University Medical Center Schleswig-Holstein; E. Siegert, Department of Rheumatology and Clinical Immunology, University of Berlin, Charité; G. Fierlbeck, MD, Department of Dermatology, University Hospital Tübingen; J. Henes, MD, Department of Rheumatology, University Hospital Tübingen; N. Blank, MD, Department of Internal Medicine, Division of Rheumatology, Heidelberg University Hospital; I. Melchers, MD, Department of Rheumatology and Clinical Immunology, University Medical Center; U. Mueller-Ladner, MD, Department of Rheumatology and Clinical Immunology, University of Giessen, Kerckhoff Clinic; M. Frerix, MD, Department of Rheumatology and Clinical Immunology, University of Giessen, Kerckhoff Clinic; A. Kreuter, MD, Department of Dermatology, HELIOS St. Elisabeth Clinic; C. Tigges, MD, Department of Dermatology, HELIOS St. Elisabeth Clinic; N. Lahner, MD, Department of Dermatology, St. Joseph Hospital, Ruhr-University of Bochum; L. Susok, MD, Department of Dermatology, St. Joseph Hospital, Ruhr-University of Bochum; C. Guenther, MD, Department of Dermatology, University Hospital Carl Gustav Carus; G. Zeidler, MD, Department of Rheumatology, Johanniter-Hospital; C. Pfeiffer, MD, Department of Dermatology, Ulm University Hospital; M. Worm, MD, Department of Dermatology, University of Berlin, Charité; S. Karrer, MD, Department of Dermatology, University Hospital Regensburg; E. Aberer, MD, Department of Dermatology, Medical University of Graz; A. Bretterklieber, MD, Department of Dermatology, Medical University of Graz; E. Genth, MD, Department of Rheumatology, Clinic of Rheumatology of Aachen; J.C. Simon, MD, Department of Dermatology, University Hospital Leipzig; J.H. Distler, MD, Department of Rheumatology, University Hospital Erlangen; R. Hein, MD, Department of Dermatology, TUM University Hospital; M. Schneider, MD, Department of Rheumatology and Nephrology, University Hospital Duesseldorf; C.S. Seitz, MD, Department of Dermatology, University Hospital Göttingen; C. Herink, MD, Department of Dermatology, University Hospital Göttingen; K. Steinbrink, MD, Department of Dermatology, University Medical Center, Johannes Gutenberg University; M. Sárdy, MD, Department of Dermatology, Ludwig Maximilian University; R. Varga, MD, Department of Dermatology, Ludwig Maximilian University; H. Mensing, MD, Clinic for Dermatology; C. Mensing, MD, Clinic for Dermatology; P. Lehmann, MD, Department of Dermatology, Helios Clinic; G. Neeck, MD, Center for Rheumatology Bad Doberan; C. Fiehn, MD, Center for Rheumatology Acura; M. Weber, MD, Department of Internal Medicine, Hospital of Cologne Merheim; M. Goebeler, MD, Department of Dermatology, University Hospital of Würzburg; H. Burkhardt, MD, Department of Rheumatology, University Hospital Frankfurt; M. Buslau, MD, Center for Rheumatology (Rehabilitation); K. Ahmadi-Simab, MD, Clinic for Internal Medicine, Klinikum Stephansplatz; A. Himsel, MD, Department of Rheumatology, GRP-Hospital Ruesselheim; A. Juche, MD, Department of Rheumatology, Immanuel Hospital; I. Koetter, MD, Department of Rheumatology, Asklepios Clinic Altona; A. Kuhn, MD, Division of Immunogenetics, German Cancer Research Center; M. Sticherling, MD, Department of Dermatology, University Hospital Erlangen; M. Hellmich, MD, Institute of Medical Statistics, Informatics and Epidemiology, University of Cologne; K. Kuhr, MD, Institute of Medical Statistics, Informatics and Epidemiology, University of Cologne; T. Krieg, MD, Department of Dermatology, University Hospital of Cologne; J. Ehrchen, MD, Department of Dermatology and Venereology, University Hospital Muenster; C. Sunderkoetter, MD, Department of Dermatology and Venereology, University Hospital Muenster; N. Hunzelmann, MD, Department of Dermatology, University Hospital of Cologne. Address correspondence to Dr. P. Moinzadeh, Department of Dermatology and Venereology, University of Cologne, Kerpener Str. 62, 50937 Cologne, Germany. E-mail: pia.moinzadeh@uk-koeln.de. Accepted for publication August 28, 2015.
Marc Frerix
From the Department of Dermatology, University Hospital of Cologne; Department of Internal Medicine, Hospital of Cologne Merheim; Institute of Medical Statistics, Informatics and Epidemiology, University of Cologne, Cologne; Department of Rheumatology, University Medical Center Schleswig-Holstein, Lübeck; Department of Rheumatology and Clinical Immunology, and Department of Dermatology, University of Berlin, Charité, Berlin; Department of Rheumatology, Immanuel Hospital, Berlin-Buch; Department of Dermatology, and Department of Rheumatology, University Hospital Tübingen, Tübingen; Department of Internal Medicine, Division of Rheumatology, Heidelberg University Hospital; Division of Immunogenetics, German Cancer Research Center, Heidelberg; Department of Rheumatology and Clinical Immunology, University Medical Center, Freiburg; Department of Rheumatology and Clinical Immunology, University of Giessen, Kerckhoff Clinic, Bad Nauheim; Department of Dermatology, HELIOS St. Elisabeth Clinic, Oberhausen; Department of Dermatology, St. Joseph Hospital, Ruhr- University of Bochum, Bochum; Department of Dermatology, University Hospital Carl Gustav Carus, Dresden; Department of Rheumatology, Johanniter-Hospital, Treuenbrietzen; Department of Dermatology, Ulm University Hospital, Ulm; Department of Dermatology, University Hospital Regensburg, Regensburg; Department of Rheumatology, Clinic of Rheumatology of Aachen, Aachen; Department of Dermatology, University Hospital Leipzig, Leipzig; Department of Rheumatology, and Department of Dermatology, University Hospital Erlangen, Erlangen; Department of Dermatology, TUM University Hospital; Department of Dermatology, Ludwig Maximilian University, Munich; Department of Rheumatology and Nephrology, University Hospital Duesseldorf, Duesseldorf; Department of Dermatology, University Hospital Göttingen, Göttingen; Department of Dermatology, University Medical Center, Johannes Gutenberg University, Mainz; Clinic for Dermatology, Hamburg Alstertal; Department of Dermatology, Helios Clinic, Wuppertal; Center for Rheumatology Bad Doberan, Bad Doberan; Center for Rheumatology Acura, Baden-Baden; Department of Dermatology, University Hospital of Würzburg, Würzburg; Department of Rheumatology, University Hospital Frankfurt, Frankfurt; Center for Rheumatology (Rehabilitation), Rheinfelden; Clinic for Internal Medicine, Klinikum Stephansplatz; Department of Rheumatology, Asklepios Clinic Altona, Hamburg; Department of Rheumatology, GRP-Hospital Ruesselheim, Darmstadt; Department of Dermatology and Venereology, University Hospital Muenster, Muenster, Germany; Department of Dermatology, Medical University of Graz, Graz, Austria. Supported by a grant of the German Federal Ministry of Education and Research (BMBF; 01GM0310 NH, TK; 01GM0631 CS) and the Edith Busch Foundation. The work of Pia Moinzadeh was supported by “Koeln Fortune” (155/2014) and “Deutsche Stiftung Sklerodermie” (3649/0096/31) grants. P. Moinzadeh, MD, Department of Dermatology, University Hospital of Cologne; G. Riemekasten, MD, Department of Rheumatology, University Medical Center Schleswig-Holstein; E. Siegert, Department of Rheumatology and Clinical Immunology, University of Berlin, Charité; G. Fierlbeck, MD, Department of Dermatology, University Hospital Tübingen; J. Henes, MD, Department of Rheumatology, University Hospital Tübingen; N. Blank, MD, Department of Internal Medicine, Division of Rheumatology, Heidelberg University Hospital; I. Melchers, MD, Department of Rheumatology and Clinical Immunology, University Medical Center; U. Mueller-Ladner, MD, Department of Rheumatology and Clinical Immunology, University of Giessen, Kerckhoff Clinic; M. Frerix, MD, Department of Rheumatology and Clinical Immunology, University of Giessen, Kerckhoff Clinic; A. Kreuter, MD, Department of Dermatology, HELIOS St. Elisabeth Clinic; C. Tigges, MD, Department of Dermatology, HELIOS St. Elisabeth Clinic; N. Lahner, MD, Department of Dermatology, St. Joseph Hospital, Ruhr-University of Bochum; L. Susok, MD, Department of Dermatology, St. Joseph Hospital, Ruhr-University of Bochum; C. Guenther, MD, Department of Dermatology, University Hospital Carl Gustav Carus; G. Zeidler, MD, Department of Rheumatology, Johanniter-Hospital; C. Pfeiffer, MD, Department of Dermatology, Ulm University Hospital; M. Worm, MD, Department of Dermatology, University of Berlin, Charité; S. Karrer, MD, Department of Dermatology, University Hospital Regensburg; E. Aberer, MD, Department of Dermatology, Medical University of Graz; A. Bretterklieber, MD, Department of Dermatology, Medical University of Graz; E. Genth, MD, Department of Rheumatology, Clinic of Rheumatology of Aachen; J.C. Simon, MD, Department of Dermatology, University Hospital Leipzig; J.H. Distler, MD, Department of Rheumatology, University Hospital Erlangen; R. Hein, MD, Department of Dermatology, TUM University Hospital; M. Schneider, MD, Department of Rheumatology and Nephrology, University Hospital Duesseldorf; C.S. Seitz, MD, Department of Dermatology, University Hospital Göttingen; C. Herink, MD, Department of Dermatology, University Hospital Göttingen; K. Steinbrink, MD, Department of Dermatology, University Medical Center, Johannes Gutenberg University; M. Sárdy, MD, Department of Dermatology, Ludwig Maximilian University; R. Varga, MD, Department of Dermatology, Ludwig Maximilian University; H. Mensing, MD, Clinic for Dermatology; C. Mensing, MD, Clinic for Dermatology; P. Lehmann, MD, Department of Dermatology, Helios Clinic; G. Neeck, MD, Center for Rheumatology Bad Doberan; C. Fiehn, MD, Center for Rheumatology Acura; M. Weber, MD, Department of Internal Medicine, Hospital of Cologne Merheim; M. Goebeler, MD, Department of Dermatology, University Hospital of Würzburg; H. Burkhardt, MD, Department of Rheumatology, University Hospital Frankfurt; M. Buslau, MD, Center for Rheumatology (Rehabilitation); K. Ahmadi-Simab, MD, Clinic for Internal Medicine, Klinikum Stephansplatz; A. Himsel, MD, Department of Rheumatology, GRP-Hospital Ruesselheim; A. Juche, MD, Department of Rheumatology, Immanuel Hospital; I. Koetter, MD, Department of Rheumatology, Asklepios Clinic Altona; A. Kuhn, MD, Division of Immunogenetics, German Cancer Research Center; M. Sticherling, MD, Department of Dermatology, University Hospital Erlangen; M. Hellmich, MD, Institute of Medical Statistics, Informatics and Epidemiology, University of Cologne; K. Kuhr, MD, Institute of Medical Statistics, Informatics and Epidemiology, University of Cologne; T. Krieg, MD, Department of Dermatology, University Hospital of Cologne; J. Ehrchen, MD, Department of Dermatology and Venereology, University Hospital Muenster; C. Sunderkoetter, MD, Department of Dermatology and Venereology, University Hospital Muenster; N. Hunzelmann, MD, Department of Dermatology, University Hospital of Cologne. Address correspondence to Dr. P. Moinzadeh, Department of Dermatology and Venereology, University of Cologne, Kerpener Str. 62, 50937 Cologne, Germany. E-mail: pia.moinzadeh@uk-koeln.de. Accepted for publication August 28, 2015.
Alexander Kreuter
From the Department of Dermatology, University Hospital of Cologne; Department of Internal Medicine, Hospital of Cologne Merheim; Institute of Medical Statistics, Informatics and Epidemiology, University of Cologne, Cologne; Department of Rheumatology, University Medical Center Schleswig-Holstein, Lübeck; Department of Rheumatology and Clinical Immunology, and Department of Dermatology, University of Berlin, Charité, Berlin; Department of Rheumatology, Immanuel Hospital, Berlin-Buch; Department of Dermatology, and Department of Rheumatology, University Hospital Tübingen, Tübingen; Department of Internal Medicine, Division of Rheumatology, Heidelberg University Hospital; Division of Immunogenetics, German Cancer Research Center, Heidelberg; Department of Rheumatology and Clinical Immunology, University Medical Center, Freiburg; Department of Rheumatology and Clinical Immunology, University of Giessen, Kerckhoff Clinic, Bad Nauheim; Department of Dermatology, HELIOS St. Elisabeth Clinic, Oberhausen; Department of Dermatology, St. Joseph Hospital, Ruhr- University of Bochum, Bochum; Department of Dermatology, University Hospital Carl Gustav Carus, Dresden; Department of Rheumatology, Johanniter-Hospital, Treuenbrietzen; Department of Dermatology, Ulm University Hospital, Ulm; Department of Dermatology, University Hospital Regensburg, Regensburg; Department of Rheumatology, Clinic of Rheumatology of Aachen, Aachen; Department of Dermatology, University Hospital Leipzig, Leipzig; Department of Rheumatology, and Department of Dermatology, University Hospital Erlangen, Erlangen; Department of Dermatology, TUM University Hospital; Department of Dermatology, Ludwig Maximilian University, Munich; Department of Rheumatology and Nephrology, University Hospital Duesseldorf, Duesseldorf; Department of Dermatology, University Hospital Göttingen, Göttingen; Department of Dermatology, University Medical Center, Johannes Gutenberg University, Mainz; Clinic for Dermatology, Hamburg Alstertal; Department of Dermatology, Helios Clinic, Wuppertal; Center for Rheumatology Bad Doberan, Bad Doberan; Center for Rheumatology Acura, Baden-Baden; Department of Dermatology, University Hospital of Würzburg, Würzburg; Department of Rheumatology, University Hospital Frankfurt, Frankfurt; Center for Rheumatology (Rehabilitation), Rheinfelden; Clinic for Internal Medicine, Klinikum Stephansplatz; Department of Rheumatology, Asklepios Clinic Altona, Hamburg; Department of Rheumatology, GRP-Hospital Ruesselheim, Darmstadt; Department of Dermatology and Venereology, University Hospital Muenster, Muenster, Germany; Department of Dermatology, Medical University of Graz, Graz, Austria. Supported by a grant of the German Federal Ministry of Education and Research (BMBF; 01GM0310 NH, TK; 01GM0631 CS) and the Edith Busch Foundation. The work of Pia Moinzadeh was supported by “Koeln Fortune” (155/2014) and “Deutsche Stiftung Sklerodermie” (3649/0096/31) grants. P. Moinzadeh, MD, Department of Dermatology, University Hospital of Cologne; G. Riemekasten, MD, Department of Rheumatology, University Medical Center Schleswig-Holstein; E. Siegert, Department of Rheumatology and Clinical Immunology, University of Berlin, Charité; G. Fierlbeck, MD, Department of Dermatology, University Hospital Tübingen; J. Henes, MD, Department of Rheumatology, University Hospital Tübingen; N. Blank, MD, Department of Internal Medicine, Division of Rheumatology, Heidelberg University Hospital; I. Melchers, MD, Department of Rheumatology and Clinical Immunology, University Medical Center; U. Mueller-Ladner, MD, Department of Rheumatology and Clinical Immunology, University of Giessen, Kerckhoff Clinic; M. Frerix, MD, Department of Rheumatology and Clinical Immunology, University of Giessen, Kerckhoff Clinic; A. Kreuter, MD, Department of Dermatology, HELIOS St. Elisabeth Clinic; C. Tigges, MD, Department of Dermatology, HELIOS St. Elisabeth Clinic; N. Lahner, MD, Department of Dermatology, St. Joseph Hospital, Ruhr-University of Bochum; L. Susok, MD, Department of Dermatology, St. Joseph Hospital, Ruhr-University of Bochum; C. Guenther, MD, Department of Dermatology, University Hospital Carl Gustav Carus; G. Zeidler, MD, Department of Rheumatology, Johanniter-Hospital; C. Pfeiffer, MD, Department of Dermatology, Ulm University Hospital; M. Worm, MD, Department of Dermatology, University of Berlin, Charité; S. Karrer, MD, Department of Dermatology, University Hospital Regensburg; E. Aberer, MD, Department of Dermatology, Medical University of Graz; A. Bretterklieber, MD, Department of Dermatology, Medical University of Graz; E. Genth, MD, Department of Rheumatology, Clinic of Rheumatology of Aachen; J.C. Simon, MD, Department of Dermatology, University Hospital Leipzig; J.H. Distler, MD, Department of Rheumatology, University Hospital Erlangen; R. Hein, MD, Department of Dermatology, TUM University Hospital; M. Schneider, MD, Department of Rheumatology and Nephrology, University Hospital Duesseldorf; C.S. Seitz, MD, Department of Dermatology, University Hospital Göttingen; C. Herink, MD, Department of Dermatology, University Hospital Göttingen; K. Steinbrink, MD, Department of Dermatology, University Medical Center, Johannes Gutenberg University; M. Sárdy, MD, Department of Dermatology, Ludwig Maximilian University; R. Varga, MD, Department of Dermatology, Ludwig Maximilian University; H. Mensing, MD, Clinic for Dermatology; C. Mensing, MD, Clinic for Dermatology; P. Lehmann, MD, Department of Dermatology, Helios Clinic; G. Neeck, MD, Center for Rheumatology Bad Doberan; C. Fiehn, MD, Center for Rheumatology Acura; M. Weber, MD, Department of Internal Medicine, Hospital of Cologne Merheim; M. Goebeler, MD, Department of Dermatology, University Hospital of Würzburg; H. Burkhardt, MD, Department of Rheumatology, University Hospital Frankfurt; M. Buslau, MD, Center for Rheumatology (Rehabilitation); K. Ahmadi-Simab, MD, Clinic for Internal Medicine, Klinikum Stephansplatz; A. Himsel, MD, Department of Rheumatology, GRP-Hospital Ruesselheim; A. Juche, MD, Department of Rheumatology, Immanuel Hospital; I. Koetter, MD, Department of Rheumatology, Asklepios Clinic Altona; A. Kuhn, MD, Division of Immunogenetics, German Cancer Research Center; M. Sticherling, MD, Department of Dermatology, University Hospital Erlangen; M. Hellmich, MD, Institute of Medical Statistics, Informatics and Epidemiology, University of Cologne; K. Kuhr, MD, Institute of Medical Statistics, Informatics and Epidemiology, University of Cologne; T. Krieg, MD, Department of Dermatology, University Hospital of Cologne; J. Ehrchen, MD, Department of Dermatology and Venereology, University Hospital Muenster; C. Sunderkoetter, MD, Department of Dermatology and Venereology, University Hospital Muenster; N. Hunzelmann, MD, Department of Dermatology, University Hospital of Cologne. Address correspondence to Dr. P. Moinzadeh, Department of Dermatology and Venereology, University of Cologne, Kerpener Str. 62, 50937 Cologne, Germany. E-mail: pia.moinzadeh@uk-koeln.de. Accepted for publication August 28, 2015.
Christian Tigges
From the Department of Dermatology, University Hospital of Cologne; Department of Internal Medicine, Hospital of Cologne Merheim; Institute of Medical Statistics, Informatics and Epidemiology, University of Cologne, Cologne; Department of Rheumatology, University Medical Center Schleswig-Holstein, Lübeck; Department of Rheumatology and Clinical Immunology, and Department of Dermatology, University of Berlin, Charité, Berlin; Department of Rheumatology, Immanuel Hospital, Berlin-Buch; Department of Dermatology, and Department of Rheumatology, University Hospital Tübingen, Tübingen; Department of Internal Medicine, Division of Rheumatology, Heidelberg University Hospital; Division of Immunogenetics, German Cancer Research Center, Heidelberg; Department of Rheumatology and Clinical Immunology, University Medical Center, Freiburg; Department of Rheumatology and Clinical Immunology, University of Giessen, Kerckhoff Clinic, Bad Nauheim; Department of Dermatology, HELIOS St. Elisabeth Clinic, Oberhausen; Department of Dermatology, St. Joseph Hospital, Ruhr- University of Bochum, Bochum; Department of Dermatology, University Hospital Carl Gustav Carus, Dresden; Department of Rheumatology, Johanniter-Hospital, Treuenbrietzen; Department of Dermatology, Ulm University Hospital, Ulm; Department of Dermatology, University Hospital Regensburg, Regensburg; Department of Rheumatology, Clinic of Rheumatology of Aachen, Aachen; Department of Dermatology, University Hospital Leipzig, Leipzig; Department of Rheumatology, and Department of Dermatology, University Hospital Erlangen, Erlangen; Department of Dermatology, TUM University Hospital; Department of Dermatology, Ludwig Maximilian University, Munich; Department of Rheumatology and Nephrology, University Hospital Duesseldorf, Duesseldorf; Department of Dermatology, University Hospital Göttingen, Göttingen; Department of Dermatology, University Medical Center, Johannes Gutenberg University, Mainz; Clinic for Dermatology, Hamburg Alstertal; Department of Dermatology, Helios Clinic, Wuppertal; Center for Rheumatology Bad Doberan, Bad Doberan; Center for Rheumatology Acura, Baden-Baden; Department of Dermatology, University Hospital of Würzburg, Würzburg; Department of Rheumatology, University Hospital Frankfurt, Frankfurt; Center for Rheumatology (Rehabilitation), Rheinfelden; Clinic for Internal Medicine, Klinikum Stephansplatz; Department of Rheumatology, Asklepios Clinic Altona, Hamburg; Department of Rheumatology, GRP-Hospital Ruesselheim, Darmstadt; Department of Dermatology and Venereology, University Hospital Muenster, Muenster, Germany; Department of Dermatology, Medical University of Graz, Graz, Austria. Supported by a grant of the German Federal Ministry of Education and Research (BMBF; 01GM0310 NH, TK; 01GM0631 CS) and the Edith Busch Foundation. The work of Pia Moinzadeh was supported by “Koeln Fortune” (155/2014) and “Deutsche Stiftung Sklerodermie” (3649/0096/31) grants. P. Moinzadeh, MD, Department of Dermatology, University Hospital of Cologne; G. Riemekasten, MD, Department of Rheumatology, University Medical Center Schleswig-Holstein; E. Siegert, Department of Rheumatology and Clinical Immunology, University of Berlin, Charité; G. Fierlbeck, MD, Department of Dermatology, University Hospital Tübingen; J. Henes, MD, Department of Rheumatology, University Hospital Tübingen; N. Blank, MD, Department of Internal Medicine, Division of Rheumatology, Heidelberg University Hospital; I. Melchers, MD, Department of Rheumatology and Clinical Immunology, University Medical Center; U. Mueller-Ladner, MD, Department of Rheumatology and Clinical Immunology, University of Giessen, Kerckhoff Clinic; M. Frerix, MD, Department of Rheumatology and Clinical Immunology, University of Giessen, Kerckhoff Clinic; A. Kreuter, MD, Department of Dermatology, HELIOS St. Elisabeth Clinic; C. Tigges, MD, Department of Dermatology, HELIOS St. Elisabeth Clinic; N. Lahner, MD, Department of Dermatology, St. Joseph Hospital, Ruhr-University of Bochum; L. Susok, MD, Department of Dermatology, St. Joseph Hospital, Ruhr-University of Bochum; C. Guenther, MD, Department of Dermatology, University Hospital Carl Gustav Carus; G. Zeidler, MD, Department of Rheumatology, Johanniter-Hospital; C. Pfeiffer, MD, Department of Dermatology, Ulm University Hospital; M. Worm, MD, Department of Dermatology, University of Berlin, Charité; S. Karrer, MD, Department of Dermatology, University Hospital Regensburg; E. Aberer, MD, Department of Dermatology, Medical University of Graz; A. Bretterklieber, MD, Department of Dermatology, Medical University of Graz; E. Genth, MD, Department of Rheumatology, Clinic of Rheumatology of Aachen; J.C. Simon, MD, Department of Dermatology, University Hospital Leipzig; J.H. Distler, MD, Department of Rheumatology, University Hospital Erlangen; R. Hein, MD, Department of Dermatology, TUM University Hospital; M. Schneider, MD, Department of Rheumatology and Nephrology, University Hospital Duesseldorf; C.S. Seitz, MD, Department of Dermatology, University Hospital Göttingen; C. Herink, MD, Department of Dermatology, University Hospital Göttingen; K. Steinbrink, MD, Department of Dermatology, University Medical Center, Johannes Gutenberg University; M. Sárdy, MD, Department of Dermatology, Ludwig Maximilian University; R. Varga, MD, Department of Dermatology, Ludwig Maximilian University; H. Mensing, MD, Clinic for Dermatology; C. Mensing, MD, Clinic for Dermatology; P. Lehmann, MD, Department of Dermatology, Helios Clinic; G. Neeck, MD, Center for Rheumatology Bad Doberan; C. Fiehn, MD, Center for Rheumatology Acura; M. Weber, MD, Department of Internal Medicine, Hospital of Cologne Merheim; M. Goebeler, MD, Department of Dermatology, University Hospital of Würzburg; H. Burkhardt, MD, Department of Rheumatology, University Hospital Frankfurt; M. Buslau, MD, Center for Rheumatology (Rehabilitation); K. Ahmadi-Simab, MD, Clinic for Internal Medicine, Klinikum Stephansplatz; A. Himsel, MD, Department of Rheumatology, GRP-Hospital Ruesselheim; A. Juche, MD, Department of Rheumatology, Immanuel Hospital; I. Koetter, MD, Department of Rheumatology, Asklepios Clinic Altona; A. Kuhn, MD, Division of Immunogenetics, German Cancer Research Center; M. Sticherling, MD, Department of Dermatology, University Hospital Erlangen; M. Hellmich, MD, Institute of Medical Statistics, Informatics and Epidemiology, University of Cologne; K. Kuhr, MD, Institute of Medical Statistics, Informatics and Epidemiology, University of Cologne; T. Krieg, MD, Department of Dermatology, University Hospital of Cologne; J. Ehrchen, MD, Department of Dermatology and Venereology, University Hospital Muenster; C. Sunderkoetter, MD, Department of Dermatology and Venereology, University Hospital Muenster; N. Hunzelmann, MD, Department of Dermatology, University Hospital of Cologne. Address correspondence to Dr. P. Moinzadeh, Department of Dermatology and Venereology, University of Cologne, Kerpener Str. 62, 50937 Cologne, Germany. E-mail: pia.moinzadeh@uk-koeln.de. Accepted for publication August 28, 2015.
Nina Lahner
From the Department of Dermatology, University Hospital of Cologne; Department of Internal Medicine, Hospital of Cologne Merheim; Institute of Medical Statistics, Informatics and Epidemiology, University of Cologne, Cologne; Department of Rheumatology, University Medical Center Schleswig-Holstein, Lübeck; Department of Rheumatology and Clinical Immunology, and Department of Dermatology, University of Berlin, Charité, Berlin; Department of Rheumatology, Immanuel Hospital, Berlin-Buch; Department of Dermatology, and Department of Rheumatology, University Hospital Tübingen, Tübingen; Department of Internal Medicine, Division of Rheumatology, Heidelberg University Hospital; Division of Immunogenetics, German Cancer Research Center, Heidelberg; Department of Rheumatology and Clinical Immunology, University Medical Center, Freiburg; Department of Rheumatology and Clinical Immunology, University of Giessen, Kerckhoff Clinic, Bad Nauheim; Department of Dermatology, HELIOS St. Elisabeth Clinic, Oberhausen; Department of Dermatology, St. Joseph Hospital, Ruhr- University of Bochum, Bochum; Department of Dermatology, University Hospital Carl Gustav Carus, Dresden; Department of Rheumatology, Johanniter-Hospital, Treuenbrietzen; Department of Dermatology, Ulm University Hospital, Ulm; Department of Dermatology, University Hospital Regensburg, Regensburg; Department of Rheumatology, Clinic of Rheumatology of Aachen, Aachen; Department of Dermatology, University Hospital Leipzig, Leipzig; Department of Rheumatology, and Department of Dermatology, University Hospital Erlangen, Erlangen; Department of Dermatology, TUM University Hospital; Department of Dermatology, Ludwig Maximilian University, Munich; Department of Rheumatology and Nephrology, University Hospital Duesseldorf, Duesseldorf; Department of Dermatology, University Hospital Göttingen, Göttingen; Department of Dermatology, University Medical Center, Johannes Gutenberg University, Mainz; Clinic for Dermatology, Hamburg Alstertal; Department of Dermatology, Helios Clinic, Wuppertal; Center for Rheumatology Bad Doberan, Bad Doberan; Center for Rheumatology Acura, Baden-Baden; Department of Dermatology, University Hospital of Würzburg, Würzburg; Department of Rheumatology, University Hospital Frankfurt, Frankfurt; Center for Rheumatology (Rehabilitation), Rheinfelden; Clinic for Internal Medicine, Klinikum Stephansplatz; Department of Rheumatology, Asklepios Clinic Altona, Hamburg; Department of Rheumatology, GRP-Hospital Ruesselheim, Darmstadt; Department of Dermatology and Venereology, University Hospital Muenster, Muenster, Germany; Department of Dermatology, Medical University of Graz, Graz, Austria. Supported by a grant of the German Federal Ministry of Education and Research (BMBF; 01GM0310 NH, TK; 01GM0631 CS) and the Edith Busch Foundation. The work of Pia Moinzadeh was supported by “Koeln Fortune” (155/2014) and “Deutsche Stiftung Sklerodermie” (3649/0096/31) grants. P. Moinzadeh, MD, Department of Dermatology, University Hospital of Cologne; G. Riemekasten, MD, Department of Rheumatology, University Medical Center Schleswig-Holstein; E. Siegert, Department of Rheumatology and Clinical Immunology, University of Berlin, Charité; G. Fierlbeck, MD, Department of Dermatology, University Hospital Tübingen; J. Henes, MD, Department of Rheumatology, University Hospital Tübingen; N. Blank, MD, Department of Internal Medicine, Division of Rheumatology, Heidelberg University Hospital; I. Melchers, MD, Department of Rheumatology and Clinical Immunology, University Medical Center; U. Mueller-Ladner, MD, Department of Rheumatology and Clinical Immunology, University of Giessen, Kerckhoff Clinic; M. Frerix, MD, Department of Rheumatology and Clinical Immunology, University of Giessen, Kerckhoff Clinic; A. Kreuter, MD, Department of Dermatology, HELIOS St. Elisabeth Clinic; C. Tigges, MD, Department of Dermatology, HELIOS St. Elisabeth Clinic; N. Lahner, MD, Department of Dermatology, St. Joseph Hospital, Ruhr-University of Bochum; L. Susok, MD, Department of Dermatology, St. Joseph Hospital, Ruhr-University of Bochum; C. Guenther, MD, Department of Dermatology, University Hospital Carl Gustav Carus; G. Zeidler, MD, Department of Rheumatology, Johanniter-Hospital; C. Pfeiffer, MD, Department of Dermatology, Ulm University Hospital; M. Worm, MD, Department of Dermatology, University of Berlin, Charité; S. Karrer, MD, Department of Dermatology, University Hospital Regensburg; E. Aberer, MD, Department of Dermatology, Medical University of Graz; A. Bretterklieber, MD, Department of Dermatology, Medical University of Graz; E. Genth, MD, Department of Rheumatology, Clinic of Rheumatology of Aachen; J.C. Simon, MD, Department of Dermatology, University Hospital Leipzig; J.H. Distler, MD, Department of Rheumatology, University Hospital Erlangen; R. Hein, MD, Department of Dermatology, TUM University Hospital; M. Schneider, MD, Department of Rheumatology and Nephrology, University Hospital Duesseldorf; C.S. Seitz, MD, Department of Dermatology, University Hospital Göttingen; C. Herink, MD, Department of Dermatology, University Hospital Göttingen; K. Steinbrink, MD, Department of Dermatology, University Medical Center, Johannes Gutenberg University; M. Sárdy, MD, Department of Dermatology, Ludwig Maximilian University; R. Varga, MD, Department of Dermatology, Ludwig Maximilian University; H. Mensing, MD, Clinic for Dermatology; C. Mensing, MD, Clinic for Dermatology; P. Lehmann, MD, Department of Dermatology, Helios Clinic; G. Neeck, MD, Center for Rheumatology Bad Doberan; C. Fiehn, MD, Center for Rheumatology Acura; M. Weber, MD, Department of Internal Medicine, Hospital of Cologne Merheim; M. Goebeler, MD, Department of Dermatology, University Hospital of Würzburg; H. Burkhardt, MD, Department of Rheumatology, University Hospital Frankfurt; M. Buslau, MD, Center for Rheumatology (Rehabilitation); K. Ahmadi-Simab, MD, Clinic for Internal Medicine, Klinikum Stephansplatz; A. Himsel, MD, Department of Rheumatology, GRP-Hospital Ruesselheim; A. Juche, MD, Department of Rheumatology, Immanuel Hospital; I. Koetter, MD, Department of Rheumatology, Asklepios Clinic Altona; A. Kuhn, MD, Division of Immunogenetics, German Cancer Research Center; M. Sticherling, MD, Department of Dermatology, University Hospital Erlangen; M. Hellmich, MD, Institute of Medical Statistics, Informatics and Epidemiology, University of Cologne; K. Kuhr, MD, Institute of Medical Statistics, Informatics and Epidemiology, University of Cologne; T. Krieg, MD, Department of Dermatology, University Hospital of Cologne; J. Ehrchen, MD, Department of Dermatology and Venereology, University Hospital Muenster; C. Sunderkoetter, MD, Department of Dermatology and Venereology, University Hospital Muenster; N. Hunzelmann, MD, Department of Dermatology, University Hospital of Cologne. Address correspondence to Dr. P. Moinzadeh, Department of Dermatology and Venereology, University of Cologne, Kerpener Str. 62, 50937 Cologne, Germany. E-mail: pia.moinzadeh@uk-koeln.de. Accepted for publication August 28, 2015.
Laura Susok
From the Department of Dermatology, University Hospital of Cologne; Department of Internal Medicine, Hospital of Cologne Merheim; Institute of Medical Statistics, Informatics and Epidemiology, University of Cologne, Cologne; Department of Rheumatology, University Medical Center Schleswig-Holstein, Lübeck; Department of Rheumatology and Clinical Immunology, and Department of Dermatology, University of Berlin, Charité, Berlin; Department of Rheumatology, Immanuel Hospital, Berlin-Buch; Department of Dermatology, and Department of Rheumatology, University Hospital Tübingen, Tübingen; Department of Internal Medicine, Division of Rheumatology, Heidelberg University Hospital; Division of Immunogenetics, German Cancer Research Center, Heidelberg; Department of Rheumatology and Clinical Immunology, University Medical Center, Freiburg; Department of Rheumatology and Clinical Immunology, University of Giessen, Kerckhoff Clinic, Bad Nauheim; Department of Dermatology, HELIOS St. Elisabeth Clinic, Oberhausen; Department of Dermatology, St. Joseph Hospital, Ruhr- University of Bochum, Bochum; Department of Dermatology, University Hospital Carl Gustav Carus, Dresden; Department of Rheumatology, Johanniter-Hospital, Treuenbrietzen; Department of Dermatology, Ulm University Hospital, Ulm; Department of Dermatology, University Hospital Regensburg, Regensburg; Department of Rheumatology, Clinic of Rheumatology of Aachen, Aachen; Department of Dermatology, University Hospital Leipzig, Leipzig; Department of Rheumatology, and Department of Dermatology, University Hospital Erlangen, Erlangen; Department of Dermatology, TUM University Hospital; Department of Dermatology, Ludwig Maximilian University, Munich; Department of Rheumatology and Nephrology, University Hospital Duesseldorf, Duesseldorf; Department of Dermatology, University Hospital Göttingen, Göttingen; Department of Dermatology, University Medical Center, Johannes Gutenberg University, Mainz; Clinic for Dermatology, Hamburg Alstertal; Department of Dermatology, Helios Clinic, Wuppertal; Center for Rheumatology Bad Doberan, Bad Doberan; Center for Rheumatology Acura, Baden-Baden; Department of Dermatology, University Hospital of Würzburg, Würzburg; Department of Rheumatology, University Hospital Frankfurt, Frankfurt; Center for Rheumatology (Rehabilitation), Rheinfelden; Clinic for Internal Medicine, Klinikum Stephansplatz; Department of Rheumatology, Asklepios Clinic Altona, Hamburg; Department of Rheumatology, GRP-Hospital Ruesselheim, Darmstadt; Department of Dermatology and Venereology, University Hospital Muenster, Muenster, Germany; Department of Dermatology, Medical University of Graz, Graz, Austria. Supported by a grant of the German Federal Ministry of Education and Research (BMBF; 01GM0310 NH, TK; 01GM0631 CS) and the Edith Busch Foundation. The work of Pia Moinzadeh was supported by “Koeln Fortune” (155/2014) and “Deutsche Stiftung Sklerodermie” (3649/0096/31) grants. P. Moinzadeh, MD, Department of Dermatology, University Hospital of Cologne; G. Riemekasten, MD, Department of Rheumatology, University Medical Center Schleswig-Holstein; E. Siegert, Department of Rheumatology and Clinical Immunology, University of Berlin, Charité; G. Fierlbeck, MD, Department of Dermatology, University Hospital Tübingen; J. Henes, MD, Department of Rheumatology, University Hospital Tübingen; N. Blank, MD, Department of Internal Medicine, Division of Rheumatology, Heidelberg University Hospital; I. Melchers, MD, Department of Rheumatology and Clinical Immunology, University Medical Center; U. Mueller-Ladner, MD, Department of Rheumatology and Clinical Immunology, University of Giessen, Kerckhoff Clinic; M. Frerix, MD, Department of Rheumatology and Clinical Immunology, University of Giessen, Kerckhoff Clinic; A. Kreuter, MD, Department of Dermatology, HELIOS St. Elisabeth Clinic; C. Tigges, MD, Department of Dermatology, HELIOS St. Elisabeth Clinic; N. Lahner, MD, Department of Dermatology, St. Joseph Hospital, Ruhr-University of Bochum; L. Susok, MD, Department of Dermatology, St. Joseph Hospital, Ruhr-University of Bochum; C. Guenther, MD, Department of Dermatology, University Hospital Carl Gustav Carus; G. Zeidler, MD, Department of Rheumatology, Johanniter-Hospital; C. Pfeiffer, MD, Department of Dermatology, Ulm University Hospital; M. Worm, MD, Department of Dermatology, University of Berlin, Charité; S. Karrer, MD, Department of Dermatology, University Hospital Regensburg; E. Aberer, MD, Department of Dermatology, Medical University of Graz; A. Bretterklieber, MD, Department of Dermatology, Medical University of Graz; E. Genth, MD, Department of Rheumatology, Clinic of Rheumatology of Aachen; J.C. Simon, MD, Department of Dermatology, University Hospital Leipzig; J.H. Distler, MD, Department of Rheumatology, University Hospital Erlangen; R. Hein, MD, Department of Dermatology, TUM University Hospital; M. Schneider, MD, Department of Rheumatology and Nephrology, University Hospital Duesseldorf; C.S. Seitz, MD, Department of Dermatology, University Hospital Göttingen; C. Herink, MD, Department of Dermatology, University Hospital Göttingen; K. Steinbrink, MD, Department of Dermatology, University Medical Center, Johannes Gutenberg University; M. Sárdy, MD, Department of Dermatology, Ludwig Maximilian University; R. Varga, MD, Department of Dermatology, Ludwig Maximilian University; H. Mensing, MD, Clinic for Dermatology; C. Mensing, MD, Clinic for Dermatology; P. Lehmann, MD, Department of Dermatology, Helios Clinic; G. Neeck, MD, Center for Rheumatology Bad Doberan; C. Fiehn, MD, Center for Rheumatology Acura; M. Weber, MD, Department of Internal Medicine, Hospital of Cologne Merheim; M. Goebeler, MD, Department of Dermatology, University Hospital of Würzburg; H. Burkhardt, MD, Department of Rheumatology, University Hospital Frankfurt; M. Buslau, MD, Center for Rheumatology (Rehabilitation); K. Ahmadi-Simab, MD, Clinic for Internal Medicine, Klinikum Stephansplatz; A. Himsel, MD, Department of Rheumatology, GRP-Hospital Ruesselheim; A. Juche, MD, Department of Rheumatology, Immanuel Hospital; I. Koetter, MD, Department of Rheumatology, Asklepios Clinic Altona; A. Kuhn, MD, Division of Immunogenetics, German Cancer Research Center; M. Sticherling, MD, Department of Dermatology, University Hospital Erlangen; M. Hellmich, MD, Institute of Medical Statistics, Informatics and Epidemiology, University of Cologne; K. Kuhr, MD, Institute of Medical Statistics, Informatics and Epidemiology, University of Cologne; T. Krieg, MD, Department of Dermatology, University Hospital of Cologne; J. Ehrchen, MD, Department of Dermatology and Venereology, University Hospital Muenster; C. Sunderkoetter, MD, Department of Dermatology and Venereology, University Hospital Muenster; N. Hunzelmann, MD, Department of Dermatology, University Hospital of Cologne. Address correspondence to Dr. P. Moinzadeh, Department of Dermatology and Venereology, University of Cologne, Kerpener Str. 62, 50937 Cologne, Germany. E-mail: pia.moinzadeh@uk-koeln.de. Accepted for publication August 28, 2015.
Claudia Guenther
From the Department of Dermatology, University Hospital of Cologne; Department of Internal Medicine, Hospital of Cologne Merheim; Institute of Medical Statistics, Informatics and Epidemiology, University of Cologne, Cologne; Department of Rheumatology, University Medical Center Schleswig-Holstein, Lübeck; Department of Rheumatology and Clinical Immunology, and Department of Dermatology, University of Berlin, Charité, Berlin; Department of Rheumatology, Immanuel Hospital, Berlin-Buch; Department of Dermatology, and Department of Rheumatology, University Hospital Tübingen, Tübingen; Department of Internal Medicine, Division of Rheumatology, Heidelberg University Hospital; Division of Immunogenetics, German Cancer Research Center, Heidelberg; Department of Rheumatology and Clinical Immunology, University Medical Center, Freiburg; Department of Rheumatology and Clinical Immunology, University of Giessen, Kerckhoff Clinic, Bad Nauheim; Department of Dermatology, HELIOS St. Elisabeth Clinic, Oberhausen; Department of Dermatology, St. Joseph Hospital, Ruhr- University of Bochum, Bochum; Department of Dermatology, University Hospital Carl Gustav Carus, Dresden; Department of Rheumatology, Johanniter-Hospital, Treuenbrietzen; Department of Dermatology, Ulm University Hospital, Ulm; Department of Dermatology, University Hospital Regensburg, Regensburg; Department of Rheumatology, Clinic of Rheumatology of Aachen, Aachen; Department of Dermatology, University Hospital Leipzig, Leipzig; Department of Rheumatology, and Department of Dermatology, University Hospital Erlangen, Erlangen; Department of Dermatology, TUM University Hospital; Department of Dermatology, Ludwig Maximilian University, Munich; Department of Rheumatology and Nephrology, University Hospital Duesseldorf, Duesseldorf; Department of Dermatology, University Hospital Göttingen, Göttingen; Department of Dermatology, University Medical Center, Johannes Gutenberg University, Mainz; Clinic for Dermatology, Hamburg Alstertal; Department of Dermatology, Helios Clinic, Wuppertal; Center for Rheumatology Bad Doberan, Bad Doberan; Center for Rheumatology Acura, Baden-Baden; Department of Dermatology, University Hospital of Würzburg, Würzburg; Department of Rheumatology, University Hospital Frankfurt, Frankfurt; Center for Rheumatology (Rehabilitation), Rheinfelden; Clinic for Internal Medicine, Klinikum Stephansplatz; Department of Rheumatology, Asklepios Clinic Altona, Hamburg; Department of Rheumatology, GRP-Hospital Ruesselheim, Darmstadt; Department of Dermatology and Venereology, University Hospital Muenster, Muenster, Germany; Department of Dermatology, Medical University of Graz, Graz, Austria. Supported by a grant of the German Federal Ministry of Education and Research (BMBF; 01GM0310 NH, TK; 01GM0631 CS) and the Edith Busch Foundation. The work of Pia Moinzadeh was supported by “Koeln Fortune” (155/2014) and “Deutsche Stiftung Sklerodermie” (3649/0096/31) grants. P. Moinzadeh, MD, Department of Dermatology, University Hospital of Cologne; G. Riemekasten, MD, Department of Rheumatology, University Medical Center Schleswig-Holstein; E. Siegert, Department of Rheumatology and Clinical Immunology, University of Berlin, Charité; G. Fierlbeck, MD, Department of Dermatology, University Hospital Tübingen; J. Henes, MD, Department of Rheumatology, University Hospital Tübingen; N. Blank, MD, Department of Internal Medicine, Division of Rheumatology, Heidelberg University Hospital; I. Melchers, MD, Department of Rheumatology and Clinical Immunology, University Medical Center; U. Mueller-Ladner, MD, Department of Rheumatology and Clinical Immunology, University of Giessen, Kerckhoff Clinic; M. Frerix, MD, Department of Rheumatology and Clinical Immunology, University of Giessen, Kerckhoff Clinic; A. Kreuter, MD, Department of Dermatology, HELIOS St. Elisabeth Clinic; C. Tigges, MD, Department of Dermatology, HELIOS St. Elisabeth Clinic; N. Lahner, MD, Department of Dermatology, St. Joseph Hospital, Ruhr-University of Bochum; L. Susok, MD, Department of Dermatology, St. Joseph Hospital, Ruhr-University of Bochum; C. Guenther, MD, Department of Dermatology, University Hospital Carl Gustav Carus; G. Zeidler, MD, Department of Rheumatology, Johanniter-Hospital; C. Pfeiffer, MD, Department of Dermatology, Ulm University Hospital; M. Worm, MD, Department of Dermatology, University of Berlin, Charité; S. Karrer, MD, Department of Dermatology, University Hospital Regensburg; E. Aberer, MD, Department of Dermatology, Medical University of Graz; A. Bretterklieber, MD, Department of Dermatology, Medical University of Graz; E. Genth, MD, Department of Rheumatology, Clinic of Rheumatology of Aachen; J.C. Simon, MD, Department of Dermatology, University Hospital Leipzig; J.H. Distler, MD, Department of Rheumatology, University Hospital Erlangen; R. Hein, MD, Department of Dermatology, TUM University Hospital; M. Schneider, MD, Department of Rheumatology and Nephrology, University Hospital Duesseldorf; C.S. Seitz, MD, Department of Dermatology, University Hospital Göttingen; C. Herink, MD, Department of Dermatology, University Hospital Göttingen; K. Steinbrink, MD, Department of Dermatology, University Medical Center, Johannes Gutenberg University; M. Sárdy, MD, Department of Dermatology, Ludwig Maximilian University; R. Varga, MD, Department of Dermatology, Ludwig Maximilian University; H. Mensing, MD, Clinic for Dermatology; C. Mensing, MD, Clinic for Dermatology; P. Lehmann, MD, Department of Dermatology, Helios Clinic; G. Neeck, MD, Center for Rheumatology Bad Doberan; C. Fiehn, MD, Center for Rheumatology Acura; M. Weber, MD, Department of Internal Medicine, Hospital of Cologne Merheim; M. Goebeler, MD, Department of Dermatology, University Hospital of Würzburg; H. Burkhardt, MD, Department of Rheumatology, University Hospital Frankfurt; M. Buslau, MD, Center for Rheumatology (Rehabilitation); K. Ahmadi-Simab, MD, Clinic for Internal Medicine, Klinikum Stephansplatz; A. Himsel, MD, Department of Rheumatology, GRP-Hospital Ruesselheim; A. Juche, MD, Department of Rheumatology, Immanuel Hospital; I. Koetter, MD, Department of Rheumatology, Asklepios Clinic Altona; A. Kuhn, MD, Division of Immunogenetics, German Cancer Research Center; M. Sticherling, MD, Department of Dermatology, University Hospital Erlangen; M. Hellmich, MD, Institute of Medical Statistics, Informatics and Epidemiology, University of Cologne; K. Kuhr, MD, Institute of Medical Statistics, Informatics and Epidemiology, University of Cologne; T. Krieg, MD, Department of Dermatology, University Hospital of Cologne; J. Ehrchen, MD, Department of Dermatology and Venereology, University Hospital Muenster; C. Sunderkoetter, MD, Department of Dermatology and Venereology, University Hospital Muenster; N. Hunzelmann, MD, Department of Dermatology, University Hospital of Cologne. Address correspondence to Dr. P. Moinzadeh, Department of Dermatology and Venereology, University of Cologne, Kerpener Str. 62, 50937 Cologne, Germany. E-mail: pia.moinzadeh@uk-koeln.de. Accepted for publication August 28, 2015.
Gabriele Zeidler
From the Department of Dermatology, University Hospital of Cologne; Department of Internal Medicine, Hospital of Cologne Merheim; Institute of Medical Statistics, Informatics and Epidemiology, University of Cologne, Cologne; Department of Rheumatology, University Medical Center Schleswig-Holstein, Lübeck; Department of Rheumatology and Clinical Immunology, and Department of Dermatology, University of Berlin, Charité, Berlin; Department of Rheumatology, Immanuel Hospital, Berlin-Buch; Department of Dermatology, and Department of Rheumatology, University Hospital Tübingen, Tübingen; Department of Internal Medicine, Division of Rheumatology, Heidelberg University Hospital; Division of Immunogenetics, German Cancer Research Center, Heidelberg; Department of Rheumatology and Clinical Immunology, University Medical Center, Freiburg; Department of Rheumatology and Clinical Immunology, University of Giessen, Kerckhoff Clinic, Bad Nauheim; Department of Dermatology, HELIOS St. Elisabeth Clinic, Oberhausen; Department of Dermatology, St. Joseph Hospital, Ruhr- University of Bochum, Bochum; Department of Dermatology, University Hospital Carl Gustav Carus, Dresden; Department of Rheumatology, Johanniter-Hospital, Treuenbrietzen; Department of Dermatology, Ulm University Hospital, Ulm; Department of Dermatology, University Hospital Regensburg, Regensburg; Department of Rheumatology, Clinic of Rheumatology of Aachen, Aachen; Department of Dermatology, University Hospital Leipzig, Leipzig; Department of Rheumatology, and Department of Dermatology, University Hospital Erlangen, Erlangen; Department of Dermatology, TUM University Hospital; Department of Dermatology, Ludwig Maximilian University, Munich; Department of Rheumatology and Nephrology, University Hospital Duesseldorf, Duesseldorf; Department of Dermatology, University Hospital Göttingen, Göttingen; Department of Dermatology, University Medical Center, Johannes Gutenberg University, Mainz; Clinic for Dermatology, Hamburg Alstertal; Department of Dermatology, Helios Clinic, Wuppertal; Center for Rheumatology Bad Doberan, Bad Doberan; Center for Rheumatology Acura, Baden-Baden; Department of Dermatology, University Hospital of Würzburg, Würzburg; Department of Rheumatology, University Hospital Frankfurt, Frankfurt; Center for Rheumatology (Rehabilitation), Rheinfelden; Clinic for Internal Medicine, Klinikum Stephansplatz; Department of Rheumatology, Asklepios Clinic Altona, Hamburg; Department of Rheumatology, GRP-Hospital Ruesselheim, Darmstadt; Department of Dermatology and Venereology, University Hospital Muenster, Muenster, Germany; Department of Dermatology, Medical University of Graz, Graz, Austria. Supported by a grant of the German Federal Ministry of Education and Research (BMBF; 01GM0310 NH, TK; 01GM0631 CS) and the Edith Busch Foundation. The work of Pia Moinzadeh was supported by “Koeln Fortune” (155/2014) and “Deutsche Stiftung Sklerodermie” (3649/0096/31) grants. P. Moinzadeh, MD, Department of Dermatology, University Hospital of Cologne; G. Riemekasten, MD, Department of Rheumatology, University Medical Center Schleswig-Holstein; E. Siegert, Department of Rheumatology and Clinical Immunology, University of Berlin, Charité; G. Fierlbeck, MD, Department of Dermatology, University Hospital Tübingen; J. Henes, MD, Department of Rheumatology, University Hospital Tübingen; N. Blank, MD, Department of Internal Medicine, Division of Rheumatology, Heidelberg University Hospital; I. Melchers, MD, Department of Rheumatology and Clinical Immunology, University Medical Center; U. Mueller-Ladner, MD, Department of Rheumatology and Clinical Immunology, University of Giessen, Kerckhoff Clinic; M. Frerix, MD, Department of Rheumatology and Clinical Immunology, University of Giessen, Kerckhoff Clinic; A. Kreuter, MD, Department of Dermatology, HELIOS St. Elisabeth Clinic; C. Tigges, MD, Department of Dermatology, HELIOS St. Elisabeth Clinic; N. Lahner, MD, Department of Dermatology, St. Joseph Hospital, Ruhr-University of Bochum; L. Susok, MD, Department of Dermatology, St. Joseph Hospital, Ruhr-University of Bochum; C. Guenther, MD, Department of Dermatology, University Hospital Carl Gustav Carus; G. Zeidler, MD, Department of Rheumatology, Johanniter-Hospital; C. Pfeiffer, MD, Department of Dermatology, Ulm University Hospital; M. Worm, MD, Department of Dermatology, University of Berlin, Charité; S. Karrer, MD, Department of Dermatology, University Hospital Regensburg; E. Aberer, MD, Department of Dermatology, Medical University of Graz; A. Bretterklieber, MD, Department of Dermatology, Medical University of Graz; E. Genth, MD, Department of Rheumatology, Clinic of Rheumatology of Aachen; J.C. Simon, MD, Department of Dermatology, University Hospital Leipzig; J.H. Distler, MD, Department of Rheumatology, University Hospital Erlangen; R. Hein, MD, Department of Dermatology, TUM University Hospital; M. Schneider, MD, Department of Rheumatology and Nephrology, University Hospital Duesseldorf; C.S. Seitz, MD, Department of Dermatology, University Hospital Göttingen; C. Herink, MD, Department of Dermatology, University Hospital Göttingen; K. Steinbrink, MD, Department of Dermatology, University Medical Center, Johannes Gutenberg University; M. Sárdy, MD, Department of Dermatology, Ludwig Maximilian University; R. Varga, MD, Department of Dermatology, Ludwig Maximilian University; H. Mensing, MD, Clinic for Dermatology; C. Mensing, MD, Clinic for Dermatology; P. Lehmann, MD, Department of Dermatology, Helios Clinic; G. Neeck, MD, Center for Rheumatology Bad Doberan; C. Fiehn, MD, Center for Rheumatology Acura; M. Weber, MD, Department of Internal Medicine, Hospital of Cologne Merheim; M. Goebeler, MD, Department of Dermatology, University Hospital of Würzburg; H. Burkhardt, MD, Department of Rheumatology, University Hospital Frankfurt; M. Buslau, MD, Center for Rheumatology (Rehabilitation); K. Ahmadi-Simab, MD, Clinic for Internal Medicine, Klinikum Stephansplatz; A. Himsel, MD, Department of Rheumatology, GRP-Hospital Ruesselheim; A. Juche, MD, Department of Rheumatology, Immanuel Hospital; I. Koetter, MD, Department of Rheumatology, Asklepios Clinic Altona; A. Kuhn, MD, Division of Immunogenetics, German Cancer Research Center; M. Sticherling, MD, Department of Dermatology, University Hospital Erlangen; M. Hellmich, MD, Institute of Medical Statistics, Informatics and Epidemiology, University of Cologne; K. Kuhr, MD, Institute of Medical Statistics, Informatics and Epidemiology, University of Cologne; T. Krieg, MD, Department of Dermatology, University Hospital of Cologne; J. Ehrchen, MD, Department of Dermatology and Venereology, University Hospital Muenster; C. Sunderkoetter, MD, Department of Dermatology and Venereology, University Hospital Muenster; N. Hunzelmann, MD, Department of Dermatology, University Hospital of Cologne. Address correspondence to Dr. P. Moinzadeh, Department of Dermatology and Venereology, University of Cologne, Kerpener Str. 62, 50937 Cologne, Germany. E-mail: pia.moinzadeh@uk-koeln.de. Accepted for publication August 28, 2015.
Christiane Pfeiffer
From the Department of Dermatology, University Hospital of Cologne; Department of Internal Medicine, Hospital of Cologne Merheim; Institute of Medical Statistics, Informatics and Epidemiology, University of Cologne, Cologne; Department of Rheumatology, University Medical Center Schleswig-Holstein, Lübeck; Department of Rheumatology and Clinical Immunology, and Department of Dermatology, University of Berlin, Charité, Berlin; Department of Rheumatology, Immanuel Hospital, Berlin-Buch; Department of Dermatology, and Department of Rheumatology, University Hospital Tübingen, Tübingen; Department of Internal Medicine, Division of Rheumatology, Heidelberg University Hospital; Division of Immunogenetics, German Cancer Research Center, Heidelberg; Department of Rheumatology and Clinical Immunology, University Medical Center, Freiburg; Department of Rheumatology and Clinical Immunology, University of Giessen, Kerckhoff Clinic, Bad Nauheim; Department of Dermatology, HELIOS St. Elisabeth Clinic, Oberhausen; Department of Dermatology, St. Joseph Hospital, Ruhr- University of Bochum, Bochum; Department of Dermatology, University Hospital Carl Gustav Carus, Dresden; Department of Rheumatology, Johanniter-Hospital, Treuenbrietzen; Department of Dermatology, Ulm University Hospital, Ulm; Department of Dermatology, University Hospital Regensburg, Regensburg; Department of Rheumatology, Clinic of Rheumatology of Aachen, Aachen; Department of Dermatology, University Hospital Leipzig, Leipzig; Department of Rheumatology, and Department of Dermatology, University Hospital Erlangen, Erlangen; Department of Dermatology, TUM University Hospital; Department of Dermatology, Ludwig Maximilian University, Munich; Department of Rheumatology and Nephrology, University Hospital Duesseldorf, Duesseldorf; Department of Dermatology, University Hospital Göttingen, Göttingen; Department of Dermatology, University Medical Center, Johannes Gutenberg University, Mainz; Clinic for Dermatology, Hamburg Alstertal; Department of Dermatology, Helios Clinic, Wuppertal; Center for Rheumatology Bad Doberan, Bad Doberan; Center for Rheumatology Acura, Baden-Baden; Department of Dermatology, University Hospital of Würzburg, Würzburg; Department of Rheumatology, University Hospital Frankfurt, Frankfurt; Center for Rheumatology (Rehabilitation), Rheinfelden; Clinic for Internal Medicine, Klinikum Stephansplatz; Department of Rheumatology, Asklepios Clinic Altona, Hamburg; Department of Rheumatology, GRP-Hospital Ruesselheim, Darmstadt; Department of Dermatology and Venereology, University Hospital Muenster, Muenster, Germany; Department of Dermatology, Medical University of Graz, Graz, Austria. Supported by a grant of the German Federal Ministry of Education and Research (BMBF; 01GM0310 NH, TK; 01GM0631 CS) and the Edith Busch Foundation. The work of Pia Moinzadeh was supported by “Koeln Fortune” (155/2014) and “Deutsche Stiftung Sklerodermie” (3649/0096/31) grants. P. Moinzadeh, MD, Department of Dermatology, University Hospital of Cologne; G. Riemekasten, MD, Department of Rheumatology, University Medical Center Schleswig-Holstein; E. Siegert, Department of Rheumatology and Clinical Immunology, University of Berlin, Charité; G. Fierlbeck, MD, Department of Dermatology, University Hospital Tübingen; J. Henes, MD, Department of Rheumatology, University Hospital Tübingen; N. Blank, MD, Department of Internal Medicine, Division of Rheumatology, Heidelberg University Hospital; I. Melchers, MD, Department of Rheumatology and Clinical Immunology, University Medical Center; U. Mueller-Ladner, MD, Department of Rheumatology and Clinical Immunology, University of Giessen, Kerckhoff Clinic; M. Frerix, MD, Department of Rheumatology and Clinical Immunology, University of Giessen, Kerckhoff Clinic; A. Kreuter, MD, Department of Dermatology, HELIOS St. Elisabeth Clinic; C. Tigges, MD, Department of Dermatology, HELIOS St. Elisabeth Clinic; N. Lahner, MD, Department of Dermatology, St. Joseph Hospital, Ruhr-University of Bochum; L. Susok, MD, Department of Dermatology, St. Joseph Hospital, Ruhr-University of Bochum; C. Guenther, MD, Department of Dermatology, University Hospital Carl Gustav Carus; G. Zeidler, MD, Department of Rheumatology, Johanniter-Hospital; C. Pfeiffer, MD, Department of Dermatology, Ulm University Hospital; M. Worm, MD, Department of Dermatology, University of Berlin, Charité; S. Karrer, MD, Department of Dermatology, University Hospital Regensburg; E. Aberer, MD, Department of Dermatology, Medical University of Graz; A. Bretterklieber, MD, Department of Dermatology, Medical University of Graz; E. Genth, MD, Department of Rheumatology, Clinic of Rheumatology of Aachen; J.C. Simon, MD, Department of Dermatology, University Hospital Leipzig; J.H. Distler, MD, Department of Rheumatology, University Hospital Erlangen; R. Hein, MD, Department of Dermatology, TUM University Hospital; M. Schneider, MD, Department of Rheumatology and Nephrology, University Hospital Duesseldorf; C.S. Seitz, MD, Department of Dermatology, University Hospital Göttingen; C. Herink, MD, Department of Dermatology, University Hospital Göttingen; K. Steinbrink, MD, Department of Dermatology, University Medical Center, Johannes Gutenberg University; M. Sárdy, MD, Department of Dermatology, Ludwig Maximilian University; R. Varga, MD, Department of Dermatology, Ludwig Maximilian University; H. Mensing, MD, Clinic for Dermatology; C. Mensing, MD, Clinic for Dermatology; P. Lehmann, MD, Department of Dermatology, Helios Clinic; G. Neeck, MD, Center for Rheumatology Bad Doberan; C. Fiehn, MD, Center for Rheumatology Acura; M. Weber, MD, Department of Internal Medicine, Hospital of Cologne Merheim; M. Goebeler, MD, Department of Dermatology, University Hospital of Würzburg; H. Burkhardt, MD, Department of Rheumatology, University Hospital Frankfurt; M. Buslau, MD, Center for Rheumatology (Rehabilitation); K. Ahmadi-Simab, MD, Clinic for Internal Medicine, Klinikum Stephansplatz; A. Himsel, MD, Department of Rheumatology, GRP-Hospital Ruesselheim; A. Juche, MD, Department of Rheumatology, Immanuel Hospital; I. Koetter, MD, Department of Rheumatology, Asklepios Clinic Altona; A. Kuhn, MD, Division of Immunogenetics, German Cancer Research Center; M. Sticherling, MD, Department of Dermatology, University Hospital Erlangen; M. Hellmich, MD, Institute of Medical Statistics, Informatics and Epidemiology, University of Cologne; K. Kuhr, MD, Institute of Medical Statistics, Informatics and Epidemiology, University of Cologne; T. Krieg, MD, Department of Dermatology, University Hospital of Cologne; J. Ehrchen, MD, Department of Dermatology and Venereology, University Hospital Muenster; C. Sunderkoetter, MD, Department of Dermatology and Venereology, University Hospital Muenster; N. Hunzelmann, MD, Department of Dermatology, University Hospital of Cologne. Address correspondence to Dr. P. Moinzadeh, Department of Dermatology and Venereology, University of Cologne, Kerpener Str. 62, 50937 Cologne, Germany. E-mail: pia.moinzadeh@uk-koeln.de. Accepted for publication August 28, 2015.
Margitta Worm
From the Department of Dermatology, University Hospital of Cologne; Department of Internal Medicine, Hospital of Cologne Merheim; Institute of Medical Statistics, Informatics and Epidemiology, University of Cologne, Cologne; Department of Rheumatology, University Medical Center Schleswig-Holstein, Lübeck; Department of Rheumatology and Clinical Immunology, and Department of Dermatology, University of Berlin, Charité, Berlin; Department of Rheumatology, Immanuel Hospital, Berlin-Buch; Department of Dermatology, and Department of Rheumatology, University Hospital Tübingen, Tübingen; Department of Internal Medicine, Division of Rheumatology, Heidelberg University Hospital; Division of Immunogenetics, German Cancer Research Center, Heidelberg; Department of Rheumatology and Clinical Immunology, University Medical Center, Freiburg; Department of Rheumatology and Clinical Immunology, University of Giessen, Kerckhoff Clinic, Bad Nauheim; Department of Dermatology, HELIOS St. Elisabeth Clinic, Oberhausen; Department of Dermatology, St. Joseph Hospital, Ruhr- University of Bochum, Bochum; Department of Dermatology, University Hospital Carl Gustav Carus, Dresden; Department of Rheumatology, Johanniter-Hospital, Treuenbrietzen; Department of Dermatology, Ulm University Hospital, Ulm; Department of Dermatology, University Hospital Regensburg, Regensburg; Department of Rheumatology, Clinic of Rheumatology of Aachen, Aachen; Department of Dermatology, University Hospital Leipzig, Leipzig; Department of Rheumatology, and Department of Dermatology, University Hospital Erlangen, Erlangen; Department of Dermatology, TUM University Hospital; Department of Dermatology, Ludwig Maximilian University, Munich; Department of Rheumatology and Nephrology, University Hospital Duesseldorf, Duesseldorf; Department of Dermatology, University Hospital Göttingen, Göttingen; Department of Dermatology, University Medical Center, Johannes Gutenberg University, Mainz; Clinic for Dermatology, Hamburg Alstertal; Department of Dermatology, Helios Clinic, Wuppertal; Center for Rheumatology Bad Doberan, Bad Doberan; Center for Rheumatology Acura, Baden-Baden; Department of Dermatology, University Hospital of Würzburg, Würzburg; Department of Rheumatology, University Hospital Frankfurt, Frankfurt; Center for Rheumatology (Rehabilitation), Rheinfelden; Clinic for Internal Medicine, Klinikum Stephansplatz; Department of Rheumatology, Asklepios Clinic Altona, Hamburg; Department of Rheumatology, GRP-Hospital Ruesselheim, Darmstadt; Department of Dermatology and Venereology, University Hospital Muenster, Muenster, Germany; Department of Dermatology, Medical University of Graz, Graz, Austria. Supported by a grant of the German Federal Ministry of Education and Research (BMBF; 01GM0310 NH, TK; 01GM0631 CS) and the Edith Busch Foundation. The work of Pia Moinzadeh was supported by “Koeln Fortune” (155/2014) and “Deutsche Stiftung Sklerodermie” (3649/0096/31) grants. P. Moinzadeh, MD, Department of Dermatology, University Hospital of Cologne; G. Riemekasten, MD, Department of Rheumatology, University Medical Center Schleswig-Holstein; E. Siegert, Department of Rheumatology and Clinical Immunology, University of Berlin, Charité; G. Fierlbeck, MD, Department of Dermatology, University Hospital Tübingen; J. Henes, MD, Department of Rheumatology, University Hospital Tübingen; N. Blank, MD, Department of Internal Medicine, Division of Rheumatology, Heidelberg University Hospital; I. Melchers, MD, Department of Rheumatology and Clinical Immunology, University Medical Center; U. Mueller-Ladner, MD, Department of Rheumatology and Clinical Immunology, University of Giessen, Kerckhoff Clinic; M. Frerix, MD, Department of Rheumatology and Clinical Immunology, University of Giessen, Kerckhoff Clinic; A. Kreuter, MD, Department of Dermatology, HELIOS St. Elisabeth Clinic; C. Tigges, MD, Department of Dermatology, HELIOS St. Elisabeth Clinic; N. Lahner, MD, Department of Dermatology, St. Joseph Hospital, Ruhr-University of Bochum; L. Susok, MD, Department of Dermatology, St. Joseph Hospital, Ruhr-University of Bochum; C. Guenther, MD, Department of Dermatology, University Hospital Carl Gustav Carus; G. Zeidler, MD, Department of Rheumatology, Johanniter-Hospital; C. Pfeiffer, MD, Department of Dermatology, Ulm University Hospital; M. Worm, MD, Department of Dermatology, University of Berlin, Charité; S. Karrer, MD, Department of Dermatology, University Hospital Regensburg; E. Aberer, MD, Department of Dermatology, Medical University of Graz; A. Bretterklieber, MD, Department of Dermatology, Medical University of Graz; E. Genth, MD, Department of Rheumatology, Clinic of Rheumatology of Aachen; J.C. Simon, MD, Department of Dermatology, University Hospital Leipzig; J.H. Distler, MD, Department of Rheumatology, University Hospital Erlangen; R. Hein, MD, Department of Dermatology, TUM University Hospital; M. Schneider, MD, Department of Rheumatology and Nephrology, University Hospital Duesseldorf; C.S. Seitz, MD, Department of Dermatology, University Hospital Göttingen; C. Herink, MD, Department of Dermatology, University Hospital Göttingen; K. Steinbrink, MD, Department of Dermatology, University Medical Center, Johannes Gutenberg University; M. Sárdy, MD, Department of Dermatology, Ludwig Maximilian University; R. Varga, MD, Department of Dermatology, Ludwig Maximilian University; H. Mensing, MD, Clinic for Dermatology; C. Mensing, MD, Clinic for Dermatology; P. Lehmann, MD, Department of Dermatology, Helios Clinic; G. Neeck, MD, Center for Rheumatology Bad Doberan; C. Fiehn, MD, Center for Rheumatology Acura; M. Weber, MD, Department of Internal Medicine, Hospital of Cologne Merheim; M. Goebeler, MD, Department of Dermatology, University Hospital of Würzburg; H. Burkhardt, MD, Department of Rheumatology, University Hospital Frankfurt; M. Buslau, MD, Center for Rheumatology (Rehabilitation); K. Ahmadi-Simab, MD, Clinic for Internal Medicine, Klinikum Stephansplatz; A. Himsel, MD, Department of Rheumatology, GRP-Hospital Ruesselheim; A. Juche, MD, Department of Rheumatology, Immanuel Hospital; I. Koetter, MD, Department of Rheumatology, Asklepios Clinic Altona; A. Kuhn, MD, Division of Immunogenetics, German Cancer Research Center; M. Sticherling, MD, Department of Dermatology, University Hospital Erlangen; M. Hellmich, MD, Institute of Medical Statistics, Informatics and Epidemiology, University of Cologne; K. Kuhr, MD, Institute of Medical Statistics, Informatics and Epidemiology, University of Cologne; T. Krieg, MD, Department of Dermatology, University Hospital of Cologne; J. Ehrchen, MD, Department of Dermatology and Venereology, University Hospital Muenster; C. Sunderkoetter, MD, Department of Dermatology and Venereology, University Hospital Muenster; N. Hunzelmann, MD, Department of Dermatology, University Hospital of Cologne. Address correspondence to Dr. P. Moinzadeh, Department of Dermatology and Venereology, University of Cologne, Kerpener Str. 62, 50937 Cologne, Germany. E-mail: pia.moinzadeh@uk-koeln.de. Accepted for publication August 28, 2015.
Sigrid Karrer
From the Department of Dermatology, University Hospital of Cologne; Department of Internal Medicine, Hospital of Cologne Merheim; Institute of Medical Statistics, Informatics and Epidemiology, University of Cologne, Cologne; Department of Rheumatology, University Medical Center Schleswig-Holstein, Lübeck; Department of Rheumatology and Clinical Immunology, and Department of Dermatology, University of Berlin, Charité, Berlin; Department of Rheumatology, Immanuel Hospital, Berlin-Buch; Department of Dermatology, and Department of Rheumatology, University Hospital Tübingen, Tübingen; Department of Internal Medicine, Division of Rheumatology, Heidelberg University Hospital; Division of Immunogenetics, German Cancer Research Center, Heidelberg; Department of Rheumatology and Clinical Immunology, University Medical Center, Freiburg; Department of Rheumatology and Clinical Immunology, University of Giessen, Kerckhoff Clinic, Bad Nauheim; Department of Dermatology, HELIOS St. Elisabeth Clinic, Oberhausen; Department of Dermatology, St. Joseph Hospital, Ruhr- University of Bochum, Bochum; Department of Dermatology, University Hospital Carl Gustav Carus, Dresden; Department of Rheumatology, Johanniter-Hospital, Treuenbrietzen; Department of Dermatology, Ulm University Hospital, Ulm; Department of Dermatology, University Hospital Regensburg, Regensburg; Department of Rheumatology, Clinic of Rheumatology of Aachen, Aachen; Department of Dermatology, University Hospital Leipzig, Leipzig; Department of Rheumatology, and Department of Dermatology, University Hospital Erlangen, Erlangen; Department of Dermatology, TUM University Hospital; Department of Dermatology, Ludwig Maximilian University, Munich; Department of Rheumatology and Nephrology, University Hospital Duesseldorf, Duesseldorf; Department of Dermatology, University Hospital Göttingen, Göttingen; Department of Dermatology, University Medical Center, Johannes Gutenberg University, Mainz; Clinic for Dermatology, Hamburg Alstertal; Department of Dermatology, Helios Clinic, Wuppertal; Center for Rheumatology Bad Doberan, Bad Doberan; Center for Rheumatology Acura, Baden-Baden; Department of Dermatology, University Hospital of Würzburg, Würzburg; Department of Rheumatology, University Hospital Frankfurt, Frankfurt; Center for Rheumatology (Rehabilitation), Rheinfelden; Clinic for Internal Medicine, Klinikum Stephansplatz; Department of Rheumatology, Asklepios Clinic Altona, Hamburg; Department of Rheumatology, GRP-Hospital Ruesselheim, Darmstadt; Department of Dermatology and Venereology, University Hospital Muenster, Muenster, Germany; Department of Dermatology, Medical University of Graz, Graz, Austria. Supported by a grant of the German Federal Ministry of Education and Research (BMBF; 01GM0310 NH, TK; 01GM0631 CS) and the Edith Busch Foundation. The work of Pia Moinzadeh was supported by “Koeln Fortune” (155/2014) and “Deutsche Stiftung Sklerodermie” (3649/0096/31) grants. P. Moinzadeh, MD, Department of Dermatology, University Hospital of Cologne; G. Riemekasten, MD, Department of Rheumatology, University Medical Center Schleswig-Holstein; E. Siegert, Department of Rheumatology and Clinical Immunology, University of Berlin, Charité; G. Fierlbeck, MD, Department of Dermatology, University Hospital Tübingen; J. Henes, MD, Department of Rheumatology, University Hospital Tübingen; N. Blank, MD, Department of Internal Medicine, Division of Rheumatology, Heidelberg University Hospital; I. Melchers, MD, Department of Rheumatology and Clinical Immunology, University Medical Center; U. Mueller-Ladner, MD, Department of Rheumatology and Clinical Immunology, University of Giessen, Kerckhoff Clinic; M. Frerix, MD, Department of Rheumatology and Clinical Immunology, University of Giessen, Kerckhoff Clinic; A. Kreuter, MD, Department of Dermatology, HELIOS St. Elisabeth Clinic; C. Tigges, MD, Department of Dermatology, HELIOS St. Elisabeth Clinic; N. Lahner, MD, Department of Dermatology, St. Joseph Hospital, Ruhr-University of Bochum; L. Susok, MD, Department of Dermatology, St. Joseph Hospital, Ruhr-University of Bochum; C. Guenther, MD, Department of Dermatology, University Hospital Carl Gustav Carus; G. Zeidler, MD, Department of Rheumatology, Johanniter-Hospital; C. Pfeiffer, MD, Department of Dermatology, Ulm University Hospital; M. Worm, MD, Department of Dermatology, University of Berlin, Charité; S. Karrer, MD, Department of Dermatology, University Hospital Regensburg; E. Aberer, MD, Department of Dermatology, Medical University of Graz; A. Bretterklieber, MD, Department of Dermatology, Medical University of Graz; E. Genth, MD, Department of Rheumatology, Clinic of Rheumatology of Aachen; J.C. Simon, MD, Department of Dermatology, University Hospital Leipzig; J.H. Distler, MD, Department of Rheumatology, University Hospital Erlangen; R. Hein, MD, Department of Dermatology, TUM University Hospital; M. Schneider, MD, Department of Rheumatology and Nephrology, University Hospital Duesseldorf; C.S. Seitz, MD, Department of Dermatology, University Hospital Göttingen; C. Herink, MD, Department of Dermatology, University Hospital Göttingen; K. Steinbrink, MD, Department of Dermatology, University Medical Center, Johannes Gutenberg University; M. Sárdy, MD, Department of Dermatology, Ludwig Maximilian University; R. Varga, MD, Department of Dermatology, Ludwig Maximilian University; H. Mensing, MD, Clinic for Dermatology; C. Mensing, MD, Clinic for Dermatology; P. Lehmann, MD, Department of Dermatology, Helios Clinic; G. Neeck, MD, Center for Rheumatology Bad Doberan; C. Fiehn, MD, Center for Rheumatology Acura; M. Weber, MD, Department of Internal Medicine, Hospital of Cologne Merheim; M. Goebeler, MD, Department of Dermatology, University Hospital of Würzburg; H. Burkhardt, MD, Department of Rheumatology, University Hospital Frankfurt; M. Buslau, MD, Center for Rheumatology (Rehabilitation); K. Ahmadi-Simab, MD, Clinic for Internal Medicine, Klinikum Stephansplatz; A. Himsel, MD, Department of Rheumatology, GRP-Hospital Ruesselheim; A. Juche, MD, Department of Rheumatology, Immanuel Hospital; I. Koetter, MD, Department of Rheumatology, Asklepios Clinic Altona; A. Kuhn, MD, Division of Immunogenetics, German Cancer Research Center; M. Sticherling, MD, Department of Dermatology, University Hospital Erlangen; M. Hellmich, MD, Institute of Medical Statistics, Informatics and Epidemiology, University of Cologne; K. Kuhr, MD, Institute of Medical Statistics, Informatics and Epidemiology, University of Cologne; T. Krieg, MD, Department of Dermatology, University Hospital of Cologne; J. Ehrchen, MD, Department of Dermatology and Venereology, University Hospital Muenster; C. Sunderkoetter, MD, Department of Dermatology and Venereology, University Hospital Muenster; N. Hunzelmann, MD, Department of Dermatology, University Hospital of Cologne. Address correspondence to Dr. P. Moinzadeh, Department of Dermatology and Venereology, University of Cologne, Kerpener Str. 62, 50937 Cologne, Germany. E-mail: pia.moinzadeh@uk-koeln.de. Accepted for publication August 28, 2015.
Elisabeth Aberer
From the Department of Dermatology, University Hospital of Cologne; Department of Internal Medicine, Hospital of Cologne Merheim; Institute of Medical Statistics, Informatics and Epidemiology, University of Cologne, Cologne; Department of Rheumatology, University Medical Center Schleswig-Holstein, Lübeck; Department of Rheumatology and Clinical Immunology, and Department of Dermatology, University of Berlin, Charité, Berlin; Department of Rheumatology, Immanuel Hospital, Berlin-Buch; Department of Dermatology, and Department of Rheumatology, University Hospital Tübingen, Tübingen; Department of Internal Medicine, Division of Rheumatology, Heidelberg University Hospital; Division of Immunogenetics, German Cancer Research Center, Heidelberg; Department of Rheumatology and Clinical Immunology, University Medical Center, Freiburg; Department of Rheumatology and Clinical Immunology, University of Giessen, Kerckhoff Clinic, Bad Nauheim; Department of Dermatology, HELIOS St. Elisabeth Clinic, Oberhausen; Department of Dermatology, St. Joseph Hospital, Ruhr- University of Bochum, Bochum; Department of Dermatology, University Hospital Carl Gustav Carus, Dresden; Department of Rheumatology, Johanniter-Hospital, Treuenbrietzen; Department of Dermatology, Ulm University Hospital, Ulm; Department of Dermatology, University Hospital Regensburg, Regensburg; Department of Rheumatology, Clinic of Rheumatology of Aachen, Aachen; Department of Dermatology, University Hospital Leipzig, Leipzig; Department of Rheumatology, and Department of Dermatology, University Hospital Erlangen, Erlangen; Department of Dermatology, TUM University Hospital; Department of Dermatology, Ludwig Maximilian University, Munich; Department of Rheumatology and Nephrology, University Hospital Duesseldorf, Duesseldorf; Department of Dermatology, University Hospital Göttingen, Göttingen; Department of Dermatology, University Medical Center, Johannes Gutenberg University, Mainz; Clinic for Dermatology, Hamburg Alstertal; Department of Dermatology, Helios Clinic, Wuppertal; Center for Rheumatology Bad Doberan, Bad Doberan; Center for Rheumatology Acura, Baden-Baden; Department of Dermatology, University Hospital of Würzburg, Würzburg; Department of Rheumatology, University Hospital Frankfurt, Frankfurt; Center for Rheumatology (Rehabilitation), Rheinfelden; Clinic for Internal Medicine, Klinikum Stephansplatz; Department of Rheumatology, Asklepios Clinic Altona, Hamburg; Department of Rheumatology, GRP-Hospital Ruesselheim, Darmstadt; Department of Dermatology and Venereology, University Hospital Muenster, Muenster, Germany; Department of Dermatology, Medical University of Graz, Graz, Austria. Supported by a grant of the German Federal Ministry of Education and Research (BMBF; 01GM0310 NH, TK; 01GM0631 CS) and the Edith Busch Foundation. The work of Pia Moinzadeh was supported by “Koeln Fortune” (155/2014) and “Deutsche Stiftung Sklerodermie” (3649/0096/31) grants. P. Moinzadeh, MD, Department of Dermatology, University Hospital of Cologne; G. Riemekasten, MD, Department of Rheumatology, University Medical Center Schleswig-Holstein; E. Siegert, Department of Rheumatology and Clinical Immunology, University of Berlin, Charité; G. Fierlbeck, MD, Department of Dermatology, University Hospital Tübingen; J. Henes, MD, Department of Rheumatology, University Hospital Tübingen; N. Blank, MD, Department of Internal Medicine, Division of Rheumatology, Heidelberg University Hospital; I. Melchers, MD, Department of Rheumatology and Clinical Immunology, University Medical Center; U. Mueller-Ladner, MD, Department of Rheumatology and Clinical Immunology, University of Giessen, Kerckhoff Clinic; M. Frerix, MD, Department of Rheumatology and Clinical Immunology, University of Giessen, Kerckhoff Clinic; A. Kreuter, MD, Department of Dermatology, HELIOS St. Elisabeth Clinic; C. Tigges, MD, Department of Dermatology, HELIOS St. Elisabeth Clinic; N. Lahner, MD, Department of Dermatology, St. Joseph Hospital, Ruhr-University of Bochum; L. Susok, MD, Department of Dermatology, St. Joseph Hospital, Ruhr-University of Bochum; C. Guenther, MD, Department of Dermatology, University Hospital Carl Gustav Carus; G. Zeidler, MD, Department of Rheumatology, Johanniter-Hospital; C. Pfeiffer, MD, Department of Dermatology, Ulm University Hospital; M. Worm, MD, Department of Dermatology, University of Berlin, Charité; S. Karrer, MD, Department of Dermatology, University Hospital Regensburg; E. Aberer, MD, Department of Dermatology, Medical University of Graz; A. Bretterklieber, MD, Department of Dermatology, Medical University of Graz; E. Genth, MD, Department of Rheumatology, Clinic of Rheumatology of Aachen; J.C. Simon, MD, Department of Dermatology, University Hospital Leipzig; J.H. Distler, MD, Department of Rheumatology, University Hospital Erlangen; R. Hein, MD, Department of Dermatology, TUM University Hospital; M. Schneider, MD, Department of Rheumatology and Nephrology, University Hospital Duesseldorf; C.S. Seitz, MD, Department of Dermatology, University Hospital Göttingen; C. Herink, MD, Department of Dermatology, University Hospital Göttingen; K. Steinbrink, MD, Department of Dermatology, University Medical Center, Johannes Gutenberg University; M. Sárdy, MD, Department of Dermatology, Ludwig Maximilian University; R. Varga, MD, Department of Dermatology, Ludwig Maximilian University; H. Mensing, MD, Clinic for Dermatology; C. Mensing, MD, Clinic for Dermatology; P. Lehmann, MD, Department of Dermatology, Helios Clinic; G. Neeck, MD, Center for Rheumatology Bad Doberan; C. Fiehn, MD, Center for Rheumatology Acura; M. Weber, MD, Department of Internal Medicine, Hospital of Cologne Merheim; M. Goebeler, MD, Department of Dermatology, University Hospital of Würzburg; H. Burkhardt, MD, Department of Rheumatology, University Hospital Frankfurt; M. Buslau, MD, Center for Rheumatology (Rehabilitation); K. Ahmadi-Simab, MD, Clinic for Internal Medicine, Klinikum Stephansplatz; A. Himsel, MD, Department of Rheumatology, GRP-Hospital Ruesselheim; A. Juche, MD, Department of Rheumatology, Immanuel Hospital; I. Koetter, MD, Department of Rheumatology, Asklepios Clinic Altona; A. Kuhn, MD, Division of Immunogenetics, German Cancer Research Center; M. Sticherling, MD, Department of Dermatology, University Hospital Erlangen; M. Hellmich, MD, Institute of Medical Statistics, Informatics and Epidemiology, University of Cologne; K. Kuhr, MD, Institute of Medical Statistics, Informatics and Epidemiology, University of Cologne; T. Krieg, MD, Department of Dermatology, University Hospital of Cologne; J. Ehrchen, MD, Department of Dermatology and Venereology, University Hospital Muenster; C. Sunderkoetter, MD, Department of Dermatology and Venereology, University Hospital Muenster; N. Hunzelmann, MD, Department of Dermatology, University Hospital of Cologne. Address correspondence to Dr. P. Moinzadeh, Department of Dermatology and Venereology, University of Cologne, Kerpener Str. 62, 50937 Cologne, Germany. E-mail: pia.moinzadeh@uk-koeln.de. Accepted for publication August 28, 2015.
Agnes Bretterklieber
From the Department of Dermatology, University Hospital of Cologne; Department of Internal Medicine, Hospital of Cologne Merheim; Institute of Medical Statistics, Informatics and Epidemiology, University of Cologne, Cologne; Department of Rheumatology, University Medical Center Schleswig-Holstein, Lübeck; Department of Rheumatology and Clinical Immunology, and Department of Dermatology, University of Berlin, Charité, Berlin; Department of Rheumatology, Immanuel Hospital, Berlin-Buch; Department of Dermatology, and Department of Rheumatology, University Hospital Tübingen, Tübingen; Department of Internal Medicine, Division of Rheumatology, Heidelberg University Hospital; Division of Immunogenetics, German Cancer Research Center, Heidelberg; Department of Rheumatology and Clinical Immunology, University Medical Center, Freiburg; Department of Rheumatology and Clinical Immunology, University of Giessen, Kerckhoff Clinic, Bad Nauheim; Department of Dermatology, HELIOS St. Elisabeth Clinic, Oberhausen; Department of Dermatology, St. Joseph Hospital, Ruhr- University of Bochum, Bochum; Department of Dermatology, University Hospital Carl Gustav Carus, Dresden; Department of Rheumatology, Johanniter-Hospital, Treuenbrietzen; Department of Dermatology, Ulm University Hospital, Ulm; Department of Dermatology, University Hospital Regensburg, Regensburg; Department of Rheumatology, Clinic of Rheumatology of Aachen, Aachen; Department of Dermatology, University Hospital Leipzig, Leipzig; Department of Rheumatology, and Department of Dermatology, University Hospital Erlangen, Erlangen; Department of Dermatology, TUM University Hospital; Department of Dermatology, Ludwig Maximilian University, Munich; Department of Rheumatology and Nephrology, University Hospital Duesseldorf, Duesseldorf; Department of Dermatology, University Hospital Göttingen, Göttingen; Department of Dermatology, University Medical Center, Johannes Gutenberg University, Mainz; Clinic for Dermatology, Hamburg Alstertal; Department of Dermatology, Helios Clinic, Wuppertal; Center for Rheumatology Bad Doberan, Bad Doberan; Center for Rheumatology Acura, Baden-Baden; Department of Dermatology, University Hospital of Würzburg, Würzburg; Department of Rheumatology, University Hospital Frankfurt, Frankfurt; Center for Rheumatology (Rehabilitation), Rheinfelden; Clinic for Internal Medicine, Klinikum Stephansplatz; Department of Rheumatology, Asklepios Clinic Altona, Hamburg; Department of Rheumatology, GRP-Hospital Ruesselheim, Darmstadt; Department of Dermatology and Venereology, University Hospital Muenster, Muenster, Germany; Department of Dermatology, Medical University of Graz, Graz, Austria. Supported by a grant of the German Federal Ministry of Education and Research (BMBF; 01GM0310 NH, TK; 01GM0631 CS) and the Edith Busch Foundation. The work of Pia Moinzadeh was supported by “Koeln Fortune” (155/2014) and “Deutsche Stiftung Sklerodermie” (3649/0096/31) grants. P. Moinzadeh, MD, Department of Dermatology, University Hospital of Cologne; G. Riemekasten, MD, Department of Rheumatology, University Medical Center Schleswig-Holstein; E. Siegert, Department of Rheumatology and Clinical Immunology, University of Berlin, Charité; G. Fierlbeck, MD, Department of Dermatology, University Hospital Tübingen; J. Henes, MD, Department of Rheumatology, University Hospital Tübingen; N. Blank, MD, Department of Internal Medicine, Division of Rheumatology, Heidelberg University Hospital; I. Melchers, MD, Department of Rheumatology and Clinical Immunology, University Medical Center; U. Mueller-Ladner, MD, Department of Rheumatology and Clinical Immunology, University of Giessen, Kerckhoff Clinic; M. Frerix, MD, Department of Rheumatology and Clinical Immunology, University of Giessen, Kerckhoff Clinic; A. Kreuter, MD, Department of Dermatology, HELIOS St. Elisabeth Clinic; C. Tigges, MD, Department of Dermatology, HELIOS St. Elisabeth Clinic; N. Lahner, MD, Department of Dermatology, St. Joseph Hospital, Ruhr-University of Bochum; L. Susok, MD, Department of Dermatology, St. Joseph Hospital, Ruhr-University of Bochum; C. Guenther, MD, Department of Dermatology, University Hospital Carl Gustav Carus; G. Zeidler, MD, Department of Rheumatology, Johanniter-Hospital; C. Pfeiffer, MD, Department of Dermatology, Ulm University Hospital; M. Worm, MD, Department of Dermatology, University of Berlin, Charité; S. Karrer, MD, Department of Dermatology, University Hospital Regensburg; E. Aberer, MD, Department of Dermatology, Medical University of Graz; A. Bretterklieber, MD, Department of Dermatology, Medical University of Graz; E. Genth, MD, Department of Rheumatology, Clinic of Rheumatology of Aachen; J.C. Simon, MD, Department of Dermatology, University Hospital Leipzig; J.H. Distler, MD, Department of Rheumatology, University Hospital Erlangen; R. Hein, MD, Department of Dermatology, TUM University Hospital; M. Schneider, MD, Department of Rheumatology and Nephrology, University Hospital Duesseldorf; C.S. Seitz, MD, Department of Dermatology, University Hospital Göttingen; C. Herink, MD, Department of Dermatology, University Hospital Göttingen; K. Steinbrink, MD, Department of Dermatology, University Medical Center, Johannes Gutenberg University; M. Sárdy, MD, Department of Dermatology, Ludwig Maximilian University; R. Varga, MD, Department of Dermatology, Ludwig Maximilian University; H. Mensing, MD, Clinic for Dermatology; C. Mensing, MD, Clinic for Dermatology; P. Lehmann, MD, Department of Dermatology, Helios Clinic; G. Neeck, MD, Center for Rheumatology Bad Doberan; C. Fiehn, MD, Center for Rheumatology Acura; M. Weber, MD, Department of Internal Medicine, Hospital of Cologne Merheim; M. Goebeler, MD, Department of Dermatology, University Hospital of Würzburg; H. Burkhardt, MD, Department of Rheumatology, University Hospital Frankfurt; M. Buslau, MD, Center for Rheumatology (Rehabilitation); K. Ahmadi-Simab, MD, Clinic for Internal Medicine, Klinikum Stephansplatz; A. Himsel, MD, Department of Rheumatology, GRP-Hospital Ruesselheim; A. Juche, MD, Department of Rheumatology, Immanuel Hospital; I. Koetter, MD, Department of Rheumatology, Asklepios Clinic Altona; A. Kuhn, MD, Division of Immunogenetics, German Cancer Research Center; M. Sticherling, MD, Department of Dermatology, University Hospital Erlangen; M. Hellmich, MD, Institute of Medical Statistics, Informatics and Epidemiology, University of Cologne; K. Kuhr, MD, Institute of Medical Statistics, Informatics and Epidemiology, University of Cologne; T. Krieg, MD, Department of Dermatology, University Hospital of Cologne; J. Ehrchen, MD, Department of Dermatology and Venereology, University Hospital Muenster; C. Sunderkoetter, MD, Department of Dermatology and Venereology, University Hospital Muenster; N. Hunzelmann, MD, Department of Dermatology, University Hospital of Cologne. Address correspondence to Dr. P. Moinzadeh, Department of Dermatology and Venereology, University of Cologne, Kerpener Str. 62, 50937 Cologne, Germany. E-mail: pia.moinzadeh@uk-koeln.de. Accepted for publication August 28, 2015.
Ekkehard Genth
From the Department of Dermatology, University Hospital of Cologne; Department of Internal Medicine, Hospital of Cologne Merheim; Institute of Medical Statistics, Informatics and Epidemiology, University of Cologne, Cologne; Department of Rheumatology, University Medical Center Schleswig-Holstein, Lübeck; Department of Rheumatology and Clinical Immunology, and Department of Dermatology, University of Berlin, Charité, Berlin; Department of Rheumatology, Immanuel Hospital, Berlin-Buch; Department of Dermatology, and Department of Rheumatology, University Hospital Tübingen, Tübingen; Department of Internal Medicine, Division of Rheumatology, Heidelberg University Hospital; Division of Immunogenetics, German Cancer Research Center, Heidelberg; Department of Rheumatology and Clinical Immunology, University Medical Center, Freiburg; Department of Rheumatology and Clinical Immunology, University of Giessen, Kerckhoff Clinic, Bad Nauheim; Department of Dermatology, HELIOS St. Elisabeth Clinic, Oberhausen; Department of Dermatology, St. Joseph Hospital, Ruhr- University of Bochum, Bochum; Department of Dermatology, University Hospital Carl Gustav Carus, Dresden; Department of Rheumatology, Johanniter-Hospital, Treuenbrietzen; Department of Dermatology, Ulm University Hospital, Ulm; Department of Dermatology, University Hospital Regensburg, Regensburg; Department of Rheumatology, Clinic of Rheumatology of Aachen, Aachen; Department of Dermatology, University Hospital Leipzig, Leipzig; Department of Rheumatology, and Department of Dermatology, University Hospital Erlangen, Erlangen; Department of Dermatology, TUM University Hospital; Department of Dermatology, Ludwig Maximilian University, Munich; Department of Rheumatology and Nephrology, University Hospital Duesseldorf, Duesseldorf; Department of Dermatology, University Hospital Göttingen, Göttingen; Department of Dermatology, University Medical Center, Johannes Gutenberg University, Mainz; Clinic for Dermatology, Hamburg Alstertal; Department of Dermatology, Helios Clinic, Wuppertal; Center for Rheumatology Bad Doberan, Bad Doberan; Center for Rheumatology Acura, Baden-Baden; Department of Dermatology, University Hospital of Würzburg, Würzburg; Department of Rheumatology, University Hospital Frankfurt, Frankfurt; Center for Rheumatology (Rehabilitation), Rheinfelden; Clinic for Internal Medicine, Klinikum Stephansplatz; Department of Rheumatology, Asklepios Clinic Altona, Hamburg; Department of Rheumatology, GRP-Hospital Ruesselheim, Darmstadt; Department of Dermatology and Venereology, University Hospital Muenster, Muenster, Germany; Department of Dermatology, Medical University of Graz, Graz, Austria. Supported by a grant of the German Federal Ministry of Education and Research (BMBF; 01GM0310 NH, TK; 01GM0631 CS) and the Edith Busch Foundation. The work of Pia Moinzadeh was supported by “Koeln Fortune” (155/2014) and “Deutsche Stiftung Sklerodermie” (3649/0096/31) grants. P. Moinzadeh, MD, Department of Dermatology, University Hospital of Cologne; G. Riemekasten, MD, Department of Rheumatology, University Medical Center Schleswig-Holstein; E. Siegert, Department of Rheumatology and Clinical Immunology, University of Berlin, Charité; G. Fierlbeck, MD, Department of Dermatology, University Hospital Tübingen; J. Henes, MD, Department of Rheumatology, University Hospital Tübingen; N. Blank, MD, Department of Internal Medicine, Division of Rheumatology, Heidelberg University Hospital; I. Melchers, MD, Department of Rheumatology and Clinical Immunology, University Medical Center; U. Mueller-Ladner, MD, Department of Rheumatology and Clinical Immunology, University of Giessen, Kerckhoff Clinic; M. Frerix, MD, Department of Rheumatology and Clinical Immunology, University of Giessen, Kerckhoff Clinic; A. Kreuter, MD, Department of Dermatology, HELIOS St. Elisabeth Clinic; C. Tigges, MD, Department of Dermatology, HELIOS St. Elisabeth Clinic; N. Lahner, MD, Department of Dermatology, St. Joseph Hospital, Ruhr-University of Bochum; L. Susok, MD, Department of Dermatology, St. Joseph Hospital, Ruhr-University of Bochum; C. Guenther, MD, Department of Dermatology, University Hospital Carl Gustav Carus; G. Zeidler, MD, Department of Rheumatology, Johanniter-Hospital; C. Pfeiffer, MD, Department of Dermatology, Ulm University Hospital; M. Worm, MD, Department of Dermatology, University of Berlin, Charité; S. Karrer, MD, Department of Dermatology, University Hospital Regensburg; E. Aberer, MD, Department of Dermatology, Medical University of Graz; A. Bretterklieber, MD, Department of Dermatology, Medical University of Graz; E. Genth, MD, Department of Rheumatology, Clinic of Rheumatology of Aachen; J.C. Simon, MD, Department of Dermatology, University Hospital Leipzig; J.H. Distler, MD, Department of Rheumatology, University Hospital Erlangen; R. Hein, MD, Department of Dermatology, TUM University Hospital; M. Schneider, MD, Department of Rheumatology and Nephrology, University Hospital Duesseldorf; C.S. Seitz, MD, Department of Dermatology, University Hospital Göttingen; C. Herink, MD, Department of Dermatology, University Hospital Göttingen; K. Steinbrink, MD, Department of Dermatology, University Medical Center, Johannes Gutenberg University; M. Sárdy, MD, Department of Dermatology, Ludwig Maximilian University; R. Varga, MD, Department of Dermatology, Ludwig Maximilian University; H. Mensing, MD, Clinic for Dermatology; C. Mensing, MD, Clinic for Dermatology; P. Lehmann, MD, Department of Dermatology, Helios Clinic; G. Neeck, MD, Center for Rheumatology Bad Doberan; C. Fiehn, MD, Center for Rheumatology Acura; M. Weber, MD, Department of Internal Medicine, Hospital of Cologne Merheim; M. Goebeler, MD, Department of Dermatology, University Hospital of Würzburg; H. Burkhardt, MD, Department of Rheumatology, University Hospital Frankfurt; M. Buslau, MD, Center for Rheumatology (Rehabilitation); K. Ahmadi-Simab, MD, Clinic for Internal Medicine, Klinikum Stephansplatz; A. Himsel, MD, Department of Rheumatology, GRP-Hospital Ruesselheim; A. Juche, MD, Department of Rheumatology, Immanuel Hospital; I. Koetter, MD, Department of Rheumatology, Asklepios Clinic Altona; A. Kuhn, MD, Division of Immunogenetics, German Cancer Research Center; M. Sticherling, MD, Department of Dermatology, University Hospital Erlangen; M. Hellmich, MD, Institute of Medical Statistics, Informatics and Epidemiology, University of Cologne; K. Kuhr, MD, Institute of Medical Statistics, Informatics and Epidemiology, University of Cologne; T. Krieg, MD, Department of Dermatology, University Hospital of Cologne; J. Ehrchen, MD, Department of Dermatology and Venereology, University Hospital Muenster; C. Sunderkoetter, MD, Department of Dermatology and Venereology, University Hospital Muenster; N. Hunzelmann, MD, Department of Dermatology, University Hospital of Cologne. Address correspondence to Dr. P. Moinzadeh, Department of Dermatology and Venereology, University of Cologne, Kerpener Str. 62, 50937 Cologne, Germany. E-mail: pia.moinzadeh@uk-koeln.de. Accepted for publication August 28, 2015.
Jan C. Simon
From the Department of Dermatology, University Hospital of Cologne; Department of Internal Medicine, Hospital of Cologne Merheim; Institute of Medical Statistics, Informatics and Epidemiology, University of Cologne, Cologne; Department of Rheumatology, University Medical Center Schleswig-Holstein, Lübeck; Department of Rheumatology and Clinical Immunology, and Department of Dermatology, University of Berlin, Charité, Berlin; Department of Rheumatology, Immanuel Hospital, Berlin-Buch; Department of Dermatology, and Department of Rheumatology, University Hospital Tübingen, Tübingen; Department of Internal Medicine, Division of Rheumatology, Heidelberg University Hospital; Division of Immunogenetics, German Cancer Research Center, Heidelberg; Department of Rheumatology and Clinical Immunology, University Medical Center, Freiburg; Department of Rheumatology and Clinical Immunology, University of Giessen, Kerckhoff Clinic, Bad Nauheim; Department of Dermatology, HELIOS St. Elisabeth Clinic, Oberhausen; Department of Dermatology, St. Joseph Hospital, Ruhr- University of Bochum, Bochum; Department of Dermatology, University Hospital Carl Gustav Carus, Dresden; Department of Rheumatology, Johanniter-Hospital, Treuenbrietzen; Department of Dermatology, Ulm University Hospital, Ulm; Department of Dermatology, University Hospital Regensburg, Regensburg; Department of Rheumatology, Clinic of Rheumatology of Aachen, Aachen; Department of Dermatology, University Hospital Leipzig, Leipzig; Department of Rheumatology, and Department of Dermatology, University Hospital Erlangen, Erlangen; Department of Dermatology, TUM University Hospital; Department of Dermatology, Ludwig Maximilian University, Munich; Department of Rheumatology and Nephrology, University Hospital Duesseldorf, Duesseldorf; Department of Dermatology, University Hospital Göttingen, Göttingen; Department of Dermatology, University Medical Center, Johannes Gutenberg University, Mainz; Clinic for Dermatology, Hamburg Alstertal; Department of Dermatology, Helios Clinic, Wuppertal; Center for Rheumatology Bad Doberan, Bad Doberan; Center for Rheumatology Acura, Baden-Baden; Department of Dermatology, University Hospital of Würzburg, Würzburg; Department of Rheumatology, University Hospital Frankfurt, Frankfurt; Center for Rheumatology (Rehabilitation), Rheinfelden; Clinic for Internal Medicine, Klinikum Stephansplatz; Department of Rheumatology, Asklepios Clinic Altona, Hamburg; Department of Rheumatology, GRP-Hospital Ruesselheim, Darmstadt; Department of Dermatology and Venereology, University Hospital Muenster, Muenster, Germany; Department of Dermatology, Medical University of Graz, Graz, Austria. Supported by a grant of the German Federal Ministry of Education and Research (BMBF; 01GM0310 NH, TK; 01GM0631 CS) and the Edith Busch Foundation. The work of Pia Moinzadeh was supported by “Koeln Fortune” (155/2014) and “Deutsche Stiftung Sklerodermie” (3649/0096/31) grants. P. Moinzadeh, MD, Department of Dermatology, University Hospital of Cologne; G. Riemekasten, MD, Department of Rheumatology, University Medical Center Schleswig-Holstein; E. Siegert, Department of Rheumatology and Clinical Immunology, University of Berlin, Charité; G. Fierlbeck, MD, Department of Dermatology, University Hospital Tübingen; J. Henes, MD, Department of Rheumatology, University Hospital Tübingen; N. Blank, MD, Department of Internal Medicine, Division of Rheumatology, Heidelberg University Hospital; I. Melchers, MD, Department of Rheumatology and Clinical Immunology, University Medical Center; U. Mueller-Ladner, MD, Department of Rheumatology and Clinical Immunology, University of Giessen, Kerckhoff Clinic; M. Frerix, MD, Department of Rheumatology and Clinical Immunology, University of Giessen, Kerckhoff Clinic; A. Kreuter, MD, Department of Dermatology, HELIOS St. Elisabeth Clinic; C. Tigges, MD, Department of Dermatology, HELIOS St. Elisabeth Clinic; N. Lahner, MD, Department of Dermatology, St. Joseph Hospital, Ruhr-University of Bochum; L. Susok, MD, Department of Dermatology, St. Joseph Hospital, Ruhr-University of Bochum; C. Guenther, MD, Department of Dermatology, University Hospital Carl Gustav Carus; G. Zeidler, MD, Department of Rheumatology, Johanniter-Hospital; C. Pfeiffer, MD, Department of Dermatology, Ulm University Hospital; M. Worm, MD, Department of Dermatology, University of Berlin, Charité; S. Karrer, MD, Department of Dermatology, University Hospital Regensburg; E. Aberer, MD, Department of Dermatology, Medical University of Graz; A. Bretterklieber, MD, Department of Dermatology, Medical University of Graz; E. Genth, MD, Department of Rheumatology, Clinic of Rheumatology of Aachen; J.C. Simon, MD, Department of Dermatology, University Hospital Leipzig; J.H. Distler, MD, Department of Rheumatology, University Hospital Erlangen; R. Hein, MD, Department of Dermatology, TUM University Hospital; M. Schneider, MD, Department of Rheumatology and Nephrology, University Hospital Duesseldorf; C.S. Seitz, MD, Department of Dermatology, University Hospital Göttingen; C. Herink, MD, Department of Dermatology, University Hospital Göttingen; K. Steinbrink, MD, Department of Dermatology, University Medical Center, Johannes Gutenberg University; M. Sárdy, MD, Department of Dermatology, Ludwig Maximilian University; R. Varga, MD, Department of Dermatology, Ludwig Maximilian University; H. Mensing, MD, Clinic for Dermatology; C. Mensing, MD, Clinic for Dermatology; P. Lehmann, MD, Department of Dermatology, Helios Clinic; G. Neeck, MD, Center for Rheumatology Bad Doberan; C. Fiehn, MD, Center for Rheumatology Acura; M. Weber, MD, Department of Internal Medicine, Hospital of Cologne Merheim; M. Goebeler, MD, Department of Dermatology, University Hospital of Würzburg; H. Burkhardt, MD, Department of Rheumatology, University Hospital Frankfurt; M. Buslau, MD, Center for Rheumatology (Rehabilitation); K. Ahmadi-Simab, MD, Clinic for Internal Medicine, Klinikum Stephansplatz; A. Himsel, MD, Department of Rheumatology, GRP-Hospital Ruesselheim; A. Juche, MD, Department of Rheumatology, Immanuel Hospital; I. Koetter, MD, Department of Rheumatology, Asklepios Clinic Altona; A. Kuhn, MD, Division of Immunogenetics, German Cancer Research Center; M. Sticherling, MD, Department of Dermatology, University Hospital Erlangen; M. Hellmich, MD, Institute of Medical Statistics, Informatics and Epidemiology, University of Cologne; K. Kuhr, MD, Institute of Medical Statistics, Informatics and Epidemiology, University of Cologne; T. Krieg, MD, Department of Dermatology, University Hospital of Cologne; J. Ehrchen, MD, Department of Dermatology and Venereology, University Hospital Muenster; C. Sunderkoetter, MD, Department of Dermatology and Venereology, University Hospital Muenster; N. Hunzelmann, MD, Department of Dermatology, University Hospital of Cologne. Address correspondence to Dr. P. Moinzadeh, Department of Dermatology and Venereology, University of Cologne, Kerpener Str. 62, 50937 Cologne, Germany. E-mail: pia.moinzadeh@uk-koeln.de. Accepted for publication August 28, 2015.
Joerg H.W. Distler
From the Department of Dermatology, University Hospital of Cologne; Department of Internal Medicine, Hospital of Cologne Merheim; Institute of Medical Statistics, Informatics and Epidemiology, University of Cologne, Cologne; Department of Rheumatology, University Medical Center Schleswig-Holstein, Lübeck; Department of Rheumatology and Clinical Immunology, and Department of Dermatology, University of Berlin, Charité, Berlin; Department of Rheumatology, Immanuel Hospital, Berlin-Buch; Department of Dermatology, and Department of Rheumatology, University Hospital Tübingen, Tübingen; Department of Internal Medicine, Division of Rheumatology, Heidelberg University Hospital; Division of Immunogenetics, German Cancer Research Center, Heidelberg; Department of Rheumatology and Clinical Immunology, University Medical Center, Freiburg; Department of Rheumatology and Clinical Immunology, University of Giessen, Kerckhoff Clinic, Bad Nauheim; Department of Dermatology, HELIOS St. Elisabeth Clinic, Oberhausen; Department of Dermatology, St. Joseph Hospital, Ruhr- University of Bochum, Bochum; Department of Dermatology, University Hospital Carl Gustav Carus, Dresden; Department of Rheumatology, Johanniter-Hospital, Treuenbrietzen; Department of Dermatology, Ulm University Hospital, Ulm; Department of Dermatology, University Hospital Regensburg, Regensburg; Department of Rheumatology, Clinic of Rheumatology of Aachen, Aachen; Department of Dermatology, University Hospital Leipzig, Leipzig; Department of Rheumatology, and Department of Dermatology, University Hospital Erlangen, Erlangen; Department of Dermatology, TUM University Hospital; Department of Dermatology, Ludwig Maximilian University, Munich; Department of Rheumatology and Nephrology, University Hospital Duesseldorf, Duesseldorf; Department of Dermatology, University Hospital Göttingen, Göttingen; Department of Dermatology, University Medical Center, Johannes Gutenberg University, Mainz; Clinic for Dermatology, Hamburg Alstertal; Department of Dermatology, Helios Clinic, Wuppertal; Center for Rheumatology Bad Doberan, Bad Doberan; Center for Rheumatology Acura, Baden-Baden; Department of Dermatology, University Hospital of Würzburg, Würzburg; Department of Rheumatology, University Hospital Frankfurt, Frankfurt; Center for Rheumatology (Rehabilitation), Rheinfelden; Clinic for Internal Medicine, Klinikum Stephansplatz; Department of Rheumatology, Asklepios Clinic Altona, Hamburg; Department of Rheumatology, GRP-Hospital Ruesselheim, Darmstadt; Department of Dermatology and Venereology, University Hospital Muenster, Muenster, Germany; Department of Dermatology, Medical University of Graz, Graz, Austria. Supported by a grant of the German Federal Ministry of Education and Research (BMBF; 01GM0310 NH, TK; 01GM0631 CS) and the Edith Busch Foundation. The work of Pia Moinzadeh was supported by “Koeln Fortune” (155/2014) and “Deutsche Stiftung Sklerodermie” (3649/0096/31) grants. P. Moinzadeh, MD, Department of Dermatology, University Hospital of Cologne; G. Riemekasten, MD, Department of Rheumatology, University Medical Center Schleswig-Holstein; E. Siegert, Department of Rheumatology and Clinical Immunology, University of Berlin, Charité; G. Fierlbeck, MD, Department of Dermatology, University Hospital Tübingen; J. Henes, MD, Department of Rheumatology, University Hospital Tübingen; N. Blank, MD, Department of Internal Medicine, Division of Rheumatology, Heidelberg University Hospital; I. Melchers, MD, Department of Rheumatology and Clinical Immunology, University Medical Center; U. Mueller-Ladner, MD, Department of Rheumatology and Clinical Immunology, University of Giessen, Kerckhoff Clinic; M. Frerix, MD, Department of Rheumatology and Clinical Immunology, University of Giessen, Kerckhoff Clinic; A. Kreuter, MD, Department of Dermatology, HELIOS St. Elisabeth Clinic; C. Tigges, MD, Department of Dermatology, HELIOS St. Elisabeth Clinic; N. Lahner, MD, Department of Dermatology, St. Joseph Hospital, Ruhr-University of Bochum; L. Susok, MD, Department of Dermatology, St. Joseph Hospital, Ruhr-University of Bochum; C. Guenther, MD, Department of Dermatology, University Hospital Carl Gustav Carus; G. Zeidler, MD, Department of Rheumatology, Johanniter-Hospital; C. Pfeiffer, MD, Department of Dermatology, Ulm University Hospital; M. Worm, MD, Department of Dermatology, University of Berlin, Charité; S. Karrer, MD, Department of Dermatology, University Hospital Regensburg; E. Aberer, MD, Department of Dermatology, Medical University of Graz; A. Bretterklieber, MD, Department of Dermatology, Medical University of Graz; E. Genth, MD, Department of Rheumatology, Clinic of Rheumatology of Aachen; J.C. Simon, MD, Department of Dermatology, University Hospital Leipzig; J.H. Distler, MD, Department of Rheumatology, University Hospital Erlangen; R. Hein, MD, Department of Dermatology, TUM University Hospital; M. Schneider, MD, Department of Rheumatology and Nephrology, University Hospital Duesseldorf; C.S. Seitz, MD, Department of Dermatology, University Hospital Göttingen; C. Herink, MD, Department of Dermatology, University Hospital Göttingen; K. Steinbrink, MD, Department of Dermatology, University Medical Center, Johannes Gutenberg University; M. Sárdy, MD, Department of Dermatology, Ludwig Maximilian University; R. Varga, MD, Department of Dermatology, Ludwig Maximilian University; H. Mensing, MD, Clinic for Dermatology; C. Mensing, MD, Clinic for Dermatology; P. Lehmann, MD, Department of Dermatology, Helios Clinic; G. Neeck, MD, Center for Rheumatology Bad Doberan; C. Fiehn, MD, Center for Rheumatology Acura; M. Weber, MD, Department of Internal Medicine, Hospital of Cologne Merheim; M. Goebeler, MD, Department of Dermatology, University Hospital of Würzburg; H. Burkhardt, MD, Department of Rheumatology, University Hospital Frankfurt; M. Buslau, MD, Center for Rheumatology (Rehabilitation); K. Ahmadi-Simab, MD, Clinic for Internal Medicine, Klinikum Stephansplatz; A. Himsel, MD, Department of Rheumatology, GRP-Hospital Ruesselheim; A. Juche, MD, Department of Rheumatology, Immanuel Hospital; I. Koetter, MD, Department of Rheumatology, Asklepios Clinic Altona; A. Kuhn, MD, Division of Immunogenetics, German Cancer Research Center; M. Sticherling, MD, Department of Dermatology, University Hospital Erlangen; M. Hellmich, MD, Institute of Medical Statistics, Informatics and Epidemiology, University of Cologne; K. Kuhr, MD, Institute of Medical Statistics, Informatics and Epidemiology, University of Cologne; T. Krieg, MD, Department of Dermatology, University Hospital of Cologne; J. Ehrchen, MD, Department of Dermatology and Venereology, University Hospital Muenster; C. Sunderkoetter, MD, Department of Dermatology and Venereology, University Hospital Muenster; N. Hunzelmann, MD, Department of Dermatology, University Hospital of Cologne. Address correspondence to Dr. P. Moinzadeh, Department of Dermatology and Venereology, University of Cologne, Kerpener Str. 62, 50937 Cologne, Germany. E-mail: pia.moinzadeh@uk-koeln.de. Accepted for publication August 28, 2015.
Ruediger Hein
From the Department of Dermatology, University Hospital of Cologne; Department of Internal Medicine, Hospital of Cologne Merheim; Institute of Medical Statistics, Informatics and Epidemiology, University of Cologne, Cologne; Department of Rheumatology, University Medical Center Schleswig-Holstein, Lübeck; Department of Rheumatology and Clinical Immunology, and Department of Dermatology, University of Berlin, Charité, Berlin; Department of Rheumatology, Immanuel Hospital, Berlin-Buch; Department of Dermatology, and Department of Rheumatology, University Hospital Tübingen, Tübingen; Department of Internal Medicine, Division of Rheumatology, Heidelberg University Hospital; Division of Immunogenetics, German Cancer Research Center, Heidelberg; Department of Rheumatology and Clinical Immunology, University Medical Center, Freiburg; Department of Rheumatology and Clinical Immunology, University of Giessen, Kerckhoff Clinic, Bad Nauheim; Department of Dermatology, HELIOS St. Elisabeth Clinic, Oberhausen; Department of Dermatology, St. Joseph Hospital, Ruhr- University of Bochum, Bochum; Department of Dermatology, University Hospital Carl Gustav Carus, Dresden; Department of Rheumatology, Johanniter-Hospital, Treuenbrietzen; Department of Dermatology, Ulm University Hospital, Ulm; Department of Dermatology, University Hospital Regensburg, Regensburg; Department of Rheumatology, Clinic of Rheumatology of Aachen, Aachen; Department of Dermatology, University Hospital Leipzig, Leipzig; Department of Rheumatology, and Department of Dermatology, University Hospital Erlangen, Erlangen; Department of Dermatology, TUM University Hospital; Department of Dermatology, Ludwig Maximilian University, Munich; Department of Rheumatology and Nephrology, University Hospital Duesseldorf, Duesseldorf; Department of Dermatology, University Hospital Göttingen, Göttingen; Department of Dermatology, University Medical Center, Johannes Gutenberg University, Mainz; Clinic for Dermatology, Hamburg Alstertal; Department of Dermatology, Helios Clinic, Wuppertal; Center for Rheumatology Bad Doberan, Bad Doberan; Center for Rheumatology Acura, Baden-Baden; Department of Dermatology, University Hospital of Würzburg, Würzburg; Department of Rheumatology, University Hospital Frankfurt, Frankfurt; Center for Rheumatology (Rehabilitation), Rheinfelden; Clinic for Internal Medicine, Klinikum Stephansplatz; Department of Rheumatology, Asklepios Clinic Altona, Hamburg; Department of Rheumatology, GRP-Hospital Ruesselheim, Darmstadt; Department of Dermatology and Venereology, University Hospital Muenster, Muenster, Germany; Department of Dermatology, Medical University of Graz, Graz, Austria. Supported by a grant of the German Federal Ministry of Education and Research (BMBF; 01GM0310 NH, TK; 01GM0631 CS) and the Edith Busch Foundation. The work of Pia Moinzadeh was supported by “Koeln Fortune” (155/2014) and “Deutsche Stiftung Sklerodermie” (3649/0096/31) grants. P. Moinzadeh, MD, Department of Dermatology, University Hospital of Cologne; G. Riemekasten, MD, Department of Rheumatology, University Medical Center Schleswig-Holstein; E. Siegert, Department of Rheumatology and Clinical Immunology, University of Berlin, Charité; G. Fierlbeck, MD, Department of Dermatology, University Hospital Tübingen; J. Henes, MD, Department of Rheumatology, University Hospital Tübingen; N. Blank, MD, Department of Internal Medicine, Division of Rheumatology, Heidelberg University Hospital; I. Melchers, MD, Department of Rheumatology and Clinical Immunology, University Medical Center; U. Mueller-Ladner, MD, Department of Rheumatology and Clinical Immunology, University of Giessen, Kerckhoff Clinic; M. Frerix, MD, Department of Rheumatology and Clinical Immunology, University of Giessen, Kerckhoff Clinic; A. Kreuter, MD, Department of Dermatology, HELIOS St. Elisabeth Clinic; C. Tigges, MD, Department of Dermatology, HELIOS St. Elisabeth Clinic; N. Lahner, MD, Department of Dermatology, St. Joseph Hospital, Ruhr-University of Bochum; L. Susok, MD, Department of Dermatology, St. Joseph Hospital, Ruhr-University of Bochum; C. Guenther, MD, Department of Dermatology, University Hospital Carl Gustav Carus; G. Zeidler, MD, Department of Rheumatology, Johanniter-Hospital; C. Pfeiffer, MD, Department of Dermatology, Ulm University Hospital; M. Worm, MD, Department of Dermatology, University of Berlin, Charité; S. Karrer, MD, Department of Dermatology, University Hospital Regensburg; E. Aberer, MD, Department of Dermatology, Medical University of Graz; A. Bretterklieber, MD, Department of Dermatology, Medical University of Graz; E. Genth, MD, Department of Rheumatology, Clinic of Rheumatology of Aachen; J.C. Simon, MD, Department of Dermatology, University Hospital Leipzig; J.H. Distler, MD, Department of Rheumatology, University Hospital Erlangen; R. Hein, MD, Department of Dermatology, TUM University Hospital; M. Schneider, MD, Department of Rheumatology and Nephrology, University Hospital Duesseldorf; C.S. Seitz, MD, Department of Dermatology, University Hospital Göttingen; C. Herink, MD, Department of Dermatology, University Hospital Göttingen; K. Steinbrink, MD, Department of Dermatology, University Medical Center, Johannes Gutenberg University; M. Sárdy, MD, Department of Dermatology, Ludwig Maximilian University; R. Varga, MD, Department of Dermatology, Ludwig Maximilian University; H. Mensing, MD, Clinic for Dermatology; C. Mensing, MD, Clinic for Dermatology; P. Lehmann, MD, Department of Dermatology, Helios Clinic; G. Neeck, MD, Center for Rheumatology Bad Doberan; C. Fiehn, MD, Center for Rheumatology Acura; M. Weber, MD, Department of Internal Medicine, Hospital of Cologne Merheim; M. Goebeler, MD, Department of Dermatology, University Hospital of Würzburg; H. Burkhardt, MD, Department of Rheumatology, University Hospital Frankfurt; M. Buslau, MD, Center for Rheumatology (Rehabilitation); K. Ahmadi-Simab, MD, Clinic for Internal Medicine, Klinikum Stephansplatz; A. Himsel, MD, Department of Rheumatology, GRP-Hospital Ruesselheim; A. Juche, MD, Department of Rheumatology, Immanuel Hospital; I. Koetter, MD, Department of Rheumatology, Asklepios Clinic Altona; A. Kuhn, MD, Division of Immunogenetics, German Cancer Research Center; M. Sticherling, MD, Department of Dermatology, University Hospital Erlangen; M. Hellmich, MD, Institute of Medical Statistics, Informatics and Epidemiology, University of Cologne; K. Kuhr, MD, Institute of Medical Statistics, Informatics and Epidemiology, University of Cologne; T. Krieg, MD, Department of Dermatology, University Hospital of Cologne; J. Ehrchen, MD, Department of Dermatology and Venereology, University Hospital Muenster; C. Sunderkoetter, MD, Department of Dermatology and Venereology, University Hospital Muenster; N. Hunzelmann, MD, Department of Dermatology, University Hospital of Cologne. Address correspondence to Dr. P. Moinzadeh, Department of Dermatology and Venereology, University of Cologne, Kerpener Str. 62, 50937 Cologne, Germany. E-mail: pia.moinzadeh@uk-koeln.de. Accepted for publication August 28, 2015.
Matthias Schneider
From the Department of Dermatology, University Hospital of Cologne; Department of Internal Medicine, Hospital of Cologne Merheim; Institute of Medical Statistics, Informatics and Epidemiology, University of Cologne, Cologne; Department of Rheumatology, University Medical Center Schleswig-Holstein, Lübeck; Department of Rheumatology and Clinical Immunology, and Department of Dermatology, University of Berlin, Charité, Berlin; Department of Rheumatology, Immanuel Hospital, Berlin-Buch; Department of Dermatology, and Department of Rheumatology, University Hospital Tübingen, Tübingen; Department of Internal Medicine, Division of Rheumatology, Heidelberg University Hospital; Division of Immunogenetics, German Cancer Research Center, Heidelberg; Department of Rheumatology and Clinical Immunology, University Medical Center, Freiburg; Department of Rheumatology and Clinical Immunology, University of Giessen, Kerckhoff Clinic, Bad Nauheim; Department of Dermatology, HELIOS St. Elisabeth Clinic, Oberhausen; Department of Dermatology, St. Joseph Hospital, Ruhr- University of Bochum, Bochum; Department of Dermatology, University Hospital Carl Gustav Carus, Dresden; Department of Rheumatology, Johanniter-Hospital, Treuenbrietzen; Department of Dermatology, Ulm University Hospital, Ulm; Department of Dermatology, University Hospital Regensburg, Regensburg; Department of Rheumatology, Clinic of Rheumatology of Aachen, Aachen; Department of Dermatology, University Hospital Leipzig, Leipzig; Department of Rheumatology, and Department of Dermatology, University Hospital Erlangen, Erlangen; Department of Dermatology, TUM University Hospital; Department of Dermatology, Ludwig Maximilian University, Munich; Department of Rheumatology and Nephrology, University Hospital Duesseldorf, Duesseldorf; Department of Dermatology, University Hospital Göttingen, Göttingen; Department of Dermatology, University Medical Center, Johannes Gutenberg University, Mainz; Clinic for Dermatology, Hamburg Alstertal; Department of Dermatology, Helios Clinic, Wuppertal; Center for Rheumatology Bad Doberan, Bad Doberan; Center for Rheumatology Acura, Baden-Baden; Department of Dermatology, University Hospital of Würzburg, Würzburg; Department of Rheumatology, University Hospital Frankfurt, Frankfurt; Center for Rheumatology (Rehabilitation), Rheinfelden; Clinic for Internal Medicine, Klinikum Stephansplatz; Department of Rheumatology, Asklepios Clinic Altona, Hamburg; Department of Rheumatology, GRP-Hospital Ruesselheim, Darmstadt; Department of Dermatology and Venereology, University Hospital Muenster, Muenster, Germany; Department of Dermatology, Medical University of Graz, Graz, Austria. Supported by a grant of the German Federal Ministry of Education and Research (BMBF; 01GM0310 NH, TK; 01GM0631 CS) and the Edith Busch Foundation. The work of Pia Moinzadeh was supported by “Koeln Fortune” (155/2014) and “Deutsche Stiftung Sklerodermie” (3649/0096/31) grants. P. Moinzadeh, MD, Department of Dermatology, University Hospital of Cologne; G. Riemekasten, MD, Department of Rheumatology, University Medical Center Schleswig-Holstein; E. Siegert, Department of Rheumatology and Clinical Immunology, University of Berlin, Charité; G. Fierlbeck, MD, Department of Dermatology, University Hospital Tübingen; J. Henes, MD, Department of Rheumatology, University Hospital Tübingen; N. Blank, MD, Department of Internal Medicine, Division of Rheumatology, Heidelberg University Hospital; I. Melchers, MD, Department of Rheumatology and Clinical Immunology, University Medical Center; U. Mueller-Ladner, MD, Department of Rheumatology and Clinical Immunology, University of Giessen, Kerckhoff Clinic; M. Frerix, MD, Department of Rheumatology and Clinical Immunology, University of Giessen, Kerckhoff Clinic; A. Kreuter, MD, Department of Dermatology, HELIOS St. Elisabeth Clinic; C. Tigges, MD, Department of Dermatology, HELIOS St. Elisabeth Clinic; N. Lahner, MD, Department of Dermatology, St. Joseph Hospital, Ruhr-University of Bochum; L. Susok, MD, Department of Dermatology, St. Joseph Hospital, Ruhr-University of Bochum; C. Guenther, MD, Department of Dermatology, University Hospital Carl Gustav Carus; G. Zeidler, MD, Department of Rheumatology, Johanniter-Hospital; C. Pfeiffer, MD, Department of Dermatology, Ulm University Hospital; M. Worm, MD, Department of Dermatology, University of Berlin, Charité; S. Karrer, MD, Department of Dermatology, University Hospital Regensburg; E. Aberer, MD, Department of Dermatology, Medical University of Graz; A. Bretterklieber, MD, Department of Dermatology, Medical University of Graz; E. Genth, MD, Department of Rheumatology, Clinic of Rheumatology of Aachen; J.C. Simon, MD, Department of Dermatology, University Hospital Leipzig; J.H. Distler, MD, Department of Rheumatology, University Hospital Erlangen; R. Hein, MD, Department of Dermatology, TUM University Hospital; M. Schneider, MD, Department of Rheumatology and Nephrology, University Hospital Duesseldorf; C.S. Seitz, MD, Department of Dermatology, University Hospital Göttingen; C. Herink, MD, Department of Dermatology, University Hospital Göttingen; K. Steinbrink, MD, Department of Dermatology, University Medical Center, Johannes Gutenberg University; M. Sárdy, MD, Department of Dermatology, Ludwig Maximilian University; R. Varga, MD, Department of Dermatology, Ludwig Maximilian University; H. Mensing, MD, Clinic for Dermatology; C. Mensing, MD, Clinic for Dermatology; P. Lehmann, MD, Department of Dermatology, Helios Clinic; G. Neeck, MD, Center for Rheumatology Bad Doberan; C. Fiehn, MD, Center for Rheumatology Acura; M. Weber, MD, Department of Internal Medicine, Hospital of Cologne Merheim; M. Goebeler, MD, Department of Dermatology, University Hospital of Würzburg; H. Burkhardt, MD, Department of Rheumatology, University Hospital Frankfurt; M. Buslau, MD, Center for Rheumatology (Rehabilitation); K. Ahmadi-Simab, MD, Clinic for Internal Medicine, Klinikum Stephansplatz; A. Himsel, MD, Department of Rheumatology, GRP-Hospital Ruesselheim; A. Juche, MD, Department of Rheumatology, Immanuel Hospital; I. Koetter, MD, Department of Rheumatology, Asklepios Clinic Altona; A. Kuhn, MD, Division of Immunogenetics, German Cancer Research Center; M. Sticherling, MD, Department of Dermatology, University Hospital Erlangen; M. Hellmich, MD, Institute of Medical Statistics, Informatics and Epidemiology, University of Cologne; K. Kuhr, MD, Institute of Medical Statistics, Informatics and Epidemiology, University of Cologne; T. Krieg, MD, Department of Dermatology, University Hospital of Cologne; J. Ehrchen, MD, Department of Dermatology and Venereology, University Hospital Muenster; C. Sunderkoetter, MD, Department of Dermatology and Venereology, University Hospital Muenster; N. Hunzelmann, MD, Department of Dermatology, University Hospital of Cologne. Address correspondence to Dr. P. Moinzadeh, Department of Dermatology and Venereology, University of Cologne, Kerpener Str. 62, 50937 Cologne, Germany. E-mail: pia.moinzadeh@uk-koeln.de. Accepted for publication August 28, 2015.
Cornelia S. Seitz
From the Department of Dermatology, University Hospital of Cologne; Department of Internal Medicine, Hospital of Cologne Merheim; Institute of Medical Statistics, Informatics and Epidemiology, University of Cologne, Cologne; Department of Rheumatology, University Medical Center Schleswig-Holstein, Lübeck; Department of Rheumatology and Clinical Immunology, and Department of Dermatology, University of Berlin, Charité, Berlin; Department of Rheumatology, Immanuel Hospital, Berlin-Buch; Department of Dermatology, and Department of Rheumatology, University Hospital Tübingen, Tübingen; Department of Internal Medicine, Division of Rheumatology, Heidelberg University Hospital; Division of Immunogenetics, German Cancer Research Center, Heidelberg; Department of Rheumatology and Clinical Immunology, University Medical Center, Freiburg; Department of Rheumatology and Clinical Immunology, University of Giessen, Kerckhoff Clinic, Bad Nauheim; Department of Dermatology, HELIOS St. Elisabeth Clinic, Oberhausen; Department of Dermatology, St. Joseph Hospital, Ruhr- University of Bochum, Bochum; Department of Dermatology, University Hospital Carl Gustav Carus, Dresden; Department of Rheumatology, Johanniter-Hospital, Treuenbrietzen; Department of Dermatology, Ulm University Hospital, Ulm; Department of Dermatology, University Hospital Regensburg, Regensburg; Department of Rheumatology, Clinic of Rheumatology of Aachen, Aachen; Department of Dermatology, University Hospital Leipzig, Leipzig; Department of Rheumatology, and Department of Dermatology, University Hospital Erlangen, Erlangen; Department of Dermatology, TUM University Hospital; Department of Dermatology, Ludwig Maximilian University, Munich; Department of Rheumatology and Nephrology, University Hospital Duesseldorf, Duesseldorf; Department of Dermatology, University Hospital Göttingen, Göttingen; Department of Dermatology, University Medical Center, Johannes Gutenberg University, Mainz; Clinic for Dermatology, Hamburg Alstertal; Department of Dermatology, Helios Clinic, Wuppertal; Center for Rheumatology Bad Doberan, Bad Doberan; Center for Rheumatology Acura, Baden-Baden; Department of Dermatology, University Hospital of Würzburg, Würzburg; Department of Rheumatology, University Hospital Frankfurt, Frankfurt; Center for Rheumatology (Rehabilitation), Rheinfelden; Clinic for Internal Medicine, Klinikum Stephansplatz; Department of Rheumatology, Asklepios Clinic Altona, Hamburg; Department of Rheumatology, GRP-Hospital Ruesselheim, Darmstadt; Department of Dermatology and Venereology, University Hospital Muenster, Muenster, Germany; Department of Dermatology, Medical University of Graz, Graz, Austria. Supported by a grant of the German Federal Ministry of Education and Research (BMBF; 01GM0310 NH, TK; 01GM0631 CS) and the Edith Busch Foundation. The work of Pia Moinzadeh was supported by “Koeln Fortune” (155/2014) and “Deutsche Stiftung Sklerodermie” (3649/0096/31) grants. P. Moinzadeh, MD, Department of Dermatology, University Hospital of Cologne; G. Riemekasten, MD, Department of Rheumatology, University Medical Center Schleswig-Holstein; E. Siegert, Department of Rheumatology and Clinical Immunology, University of Berlin, Charité; G. Fierlbeck, MD, Department of Dermatology, University Hospital Tübingen; J. Henes, MD, Department of Rheumatology, University Hospital Tübingen; N. Blank, MD, Department of Internal Medicine, Division of Rheumatology, Heidelberg University Hospital; I. Melchers, MD, Department of Rheumatology and Clinical Immunology, University Medical Center; U. Mueller-Ladner, MD, Department of Rheumatology and Clinical Immunology, University of Giessen, Kerckhoff Clinic; M. Frerix, MD, Department of Rheumatology and Clinical Immunology, University of Giessen, Kerckhoff Clinic; A. Kreuter, MD, Department of Dermatology, HELIOS St. Elisabeth Clinic; C. Tigges, MD, Department of Dermatology, HELIOS St. Elisabeth Clinic; N. Lahner, MD, Department of Dermatology, St. Joseph Hospital, Ruhr-University of Bochum; L. Susok, MD, Department of Dermatology, St. Joseph Hospital, Ruhr-University of Bochum; C. Guenther, MD, Department of Dermatology, University Hospital Carl Gustav Carus; G. Zeidler, MD, Department of Rheumatology, Johanniter-Hospital; C. Pfeiffer, MD, Department of Dermatology, Ulm University Hospital; M. Worm, MD, Department of Dermatology, University of Berlin, Charité; S. Karrer, MD, Department of Dermatology, University Hospital Regensburg; E. Aberer, MD, Department of Dermatology, Medical University of Graz; A. Bretterklieber, MD, Department of Dermatology, Medical University of Graz; E. Genth, MD, Department of Rheumatology, Clinic of Rheumatology of Aachen; J.C. Simon, MD, Department of Dermatology, University Hospital Leipzig; J.H. Distler, MD, Department of Rheumatology, University Hospital Erlangen; R. Hein, MD, Department of Dermatology, TUM University Hospital; M. Schneider, MD, Department of Rheumatology and Nephrology, University Hospital Duesseldorf; C.S. Seitz, MD, Department of Dermatology, University Hospital Göttingen; C. Herink, MD, Department of Dermatology, University Hospital Göttingen; K. Steinbrink, MD, Department of Dermatology, University Medical Center, Johannes Gutenberg University; M. Sárdy, MD, Department of Dermatology, Ludwig Maximilian University; R. Varga, MD, Department of Dermatology, Ludwig Maximilian University; H. Mensing, MD, Clinic for Dermatology; C. Mensing, MD, Clinic for Dermatology; P. Lehmann, MD, Department of Dermatology, Helios Clinic; G. Neeck, MD, Center for Rheumatology Bad Doberan; C. Fiehn, MD, Center for Rheumatology Acura; M. Weber, MD, Department of Internal Medicine, Hospital of Cologne Merheim; M. Goebeler, MD, Department of Dermatology, University Hospital of Würzburg; H. Burkhardt, MD, Department of Rheumatology, University Hospital Frankfurt; M. Buslau, MD, Center for Rheumatology (Rehabilitation); K. Ahmadi-Simab, MD, Clinic for Internal Medicine, Klinikum Stephansplatz; A. Himsel, MD, Department of Rheumatology, GRP-Hospital Ruesselheim; A. Juche, MD, Department of Rheumatology, Immanuel Hospital; I. Koetter, MD, Department of Rheumatology, Asklepios Clinic Altona; A. Kuhn, MD, Division of Immunogenetics, German Cancer Research Center; M. Sticherling, MD, Department of Dermatology, University Hospital Erlangen; M. Hellmich, MD, Institute of Medical Statistics, Informatics and Epidemiology, University of Cologne; K. Kuhr, MD, Institute of Medical Statistics, Informatics and Epidemiology, University of Cologne; T. Krieg, MD, Department of Dermatology, University Hospital of Cologne; J. Ehrchen, MD, Department of Dermatology and Venereology, University Hospital Muenster; C. Sunderkoetter, MD, Department of Dermatology and Venereology, University Hospital Muenster; N. Hunzelmann, MD, Department of Dermatology, University Hospital of Cologne. Address correspondence to Dr. P. Moinzadeh, Department of Dermatology and Venereology, University of Cologne, Kerpener Str. 62, 50937 Cologne, Germany. E-mail: pia.moinzadeh@uk-koeln.de. Accepted for publication August 28, 2015.
Claudia Herink
From the Department of Dermatology, University Hospital of Cologne; Department of Internal Medicine, Hospital of Cologne Merheim; Institute of Medical Statistics, Informatics and Epidemiology, University of Cologne, Cologne; Department of Rheumatology, University Medical Center Schleswig-Holstein, Lübeck; Department of Rheumatology and Clinical Immunology, and Department of Dermatology, University of Berlin, Charité, Berlin; Department of Rheumatology, Immanuel Hospital, Berlin-Buch; Department of Dermatology, and Department of Rheumatology, University Hospital Tübingen, Tübingen; Department of Internal Medicine, Division of Rheumatology, Heidelberg University Hospital; Division of Immunogenetics, German Cancer Research Center, Heidelberg; Department of Rheumatology and Clinical Immunology, University Medical Center, Freiburg; Department of Rheumatology and Clinical Immunology, University of Giessen, Kerckhoff Clinic, Bad Nauheim; Department of Dermatology, HELIOS St. Elisabeth Clinic, Oberhausen; Department of Dermatology, St. Joseph Hospital, Ruhr- University of Bochum, Bochum; Department of Dermatology, University Hospital Carl Gustav Carus, Dresden; Department of Rheumatology, Johanniter-Hospital, Treuenbrietzen; Department of Dermatology, Ulm University Hospital, Ulm; Department of Dermatology, University Hospital Regensburg, Regensburg; Department of Rheumatology, Clinic of Rheumatology of Aachen, Aachen; Department of Dermatology, University Hospital Leipzig, Leipzig; Department of Rheumatology, and Department of Dermatology, University Hospital Erlangen, Erlangen; Department of Dermatology, TUM University Hospital; Department of Dermatology, Ludwig Maximilian University, Munich; Department of Rheumatology and Nephrology, University Hospital Duesseldorf, Duesseldorf; Department of Dermatology, University Hospital Göttingen, Göttingen; Department of Dermatology, University Medical Center, Johannes Gutenberg University, Mainz; Clinic for Dermatology, Hamburg Alstertal; Department of Dermatology, Helios Clinic, Wuppertal; Center for Rheumatology Bad Doberan, Bad Doberan; Center for Rheumatology Acura, Baden-Baden; Department of Dermatology, University Hospital of Würzburg, Würzburg; Department of Rheumatology, University Hospital Frankfurt, Frankfurt; Center for Rheumatology (Rehabilitation), Rheinfelden; Clinic for Internal Medicine, Klinikum Stephansplatz; Department of Rheumatology, Asklepios Clinic Altona, Hamburg; Department of Rheumatology, GRP-Hospital Ruesselheim, Darmstadt; Department of Dermatology and Venereology, University Hospital Muenster, Muenster, Germany; Department of Dermatology, Medical University of Graz, Graz, Austria. Supported by a grant of the German Federal Ministry of Education and Research (BMBF; 01GM0310 NH, TK; 01GM0631 CS) and the Edith Busch Foundation. The work of Pia Moinzadeh was supported by “Koeln Fortune” (155/2014) and “Deutsche Stiftung Sklerodermie” (3649/0096/31) grants. P. Moinzadeh, MD, Department of Dermatology, University Hospital of Cologne; G. Riemekasten, MD, Department of Rheumatology, University Medical Center Schleswig-Holstein; E. Siegert, Department of Rheumatology and Clinical Immunology, University of Berlin, Charité; G. Fierlbeck, MD, Department of Dermatology, University Hospital Tübingen; J. Henes, MD, Department of Rheumatology, University Hospital Tübingen; N. Blank, MD, Department of Internal Medicine, Division of Rheumatology, Heidelberg University Hospital; I. Melchers, MD, Department of Rheumatology and Clinical Immunology, University Medical Center; U. Mueller-Ladner, MD, Department of Rheumatology and Clinical Immunology, University of Giessen, Kerckhoff Clinic; M. Frerix, MD, Department of Rheumatology and Clinical Immunology, University of Giessen, Kerckhoff Clinic; A. Kreuter, MD, Department of Dermatology, HELIOS St. Elisabeth Clinic; C. Tigges, MD, Department of Dermatology, HELIOS St. Elisabeth Clinic; N. Lahner, MD, Department of Dermatology, St. Joseph Hospital, Ruhr-University of Bochum; L. Susok, MD, Department of Dermatology, St. Joseph Hospital, Ruhr-University of Bochum; C. Guenther, MD, Department of Dermatology, University Hospital Carl Gustav Carus; G. Zeidler, MD, Department of Rheumatology, Johanniter-Hospital; C. Pfeiffer, MD, Department of Dermatology, Ulm University Hospital; M. Worm, MD, Department of Dermatology, University of Berlin, Charité; S. Karrer, MD, Department of Dermatology, University Hospital Regensburg; E. Aberer, MD, Department of Dermatology, Medical University of Graz; A. Bretterklieber, MD, Department of Dermatology, Medical University of Graz; E. Genth, MD, Department of Rheumatology, Clinic of Rheumatology of Aachen; J.C. Simon, MD, Department of Dermatology, University Hospital Leipzig; J.H. Distler, MD, Department of Rheumatology, University Hospital Erlangen; R. Hein, MD, Department of Dermatology, TUM University Hospital; M. Schneider, MD, Department of Rheumatology and Nephrology, University Hospital Duesseldorf; C.S. Seitz, MD, Department of Dermatology, University Hospital Göttingen; C. Herink, MD, Department of Dermatology, University Hospital Göttingen; K. Steinbrink, MD, Department of Dermatology, University Medical Center, Johannes Gutenberg University; M. Sárdy, MD, Department of Dermatology, Ludwig Maximilian University; R. Varga, MD, Department of Dermatology, Ludwig Maximilian University; H. Mensing, MD, Clinic for Dermatology; C. Mensing, MD, Clinic for Dermatology; P. Lehmann, MD, Department of Dermatology, Helios Clinic; G. Neeck, MD, Center for Rheumatology Bad Doberan; C. Fiehn, MD, Center for Rheumatology Acura; M. Weber, MD, Department of Internal Medicine, Hospital of Cologne Merheim; M. Goebeler, MD, Department of Dermatology, University Hospital of Würzburg; H. Burkhardt, MD, Department of Rheumatology, University Hospital Frankfurt; M. Buslau, MD, Center for Rheumatology (Rehabilitation); K. Ahmadi-Simab, MD, Clinic for Internal Medicine, Klinikum Stephansplatz; A. Himsel, MD, Department of Rheumatology, GRP-Hospital Ruesselheim; A. Juche, MD, Department of Rheumatology, Immanuel Hospital; I. Koetter, MD, Department of Rheumatology, Asklepios Clinic Altona; A. Kuhn, MD, Division of Immunogenetics, German Cancer Research Center; M. Sticherling, MD, Department of Dermatology, University Hospital Erlangen; M. Hellmich, MD, Institute of Medical Statistics, Informatics and Epidemiology, University of Cologne; K. Kuhr, MD, Institute of Medical Statistics, Informatics and Epidemiology, University of Cologne; T. Krieg, MD, Department of Dermatology, University Hospital of Cologne; J. Ehrchen, MD, Department of Dermatology and Venereology, University Hospital Muenster; C. Sunderkoetter, MD, Department of Dermatology and Venereology, University Hospital Muenster; N. Hunzelmann, MD, Department of Dermatology, University Hospital of Cologne. Address correspondence to Dr. P. Moinzadeh, Department of Dermatology and Venereology, University of Cologne, Kerpener Str. 62, 50937 Cologne, Germany. E-mail: pia.moinzadeh@uk-koeln.de. Accepted for publication August 28, 2015.
Kerstin Steinbrink
From the Department of Dermatology, University Hospital of Cologne; Department of Internal Medicine, Hospital of Cologne Merheim; Institute of Medical Statistics, Informatics and Epidemiology, University of Cologne, Cologne; Department of Rheumatology, University Medical Center Schleswig-Holstein, Lübeck; Department of Rheumatology and Clinical Immunology, and Department of Dermatology, University of Berlin, Charité, Berlin; Department of Rheumatology, Immanuel Hospital, Berlin-Buch; Department of Dermatology, and Department of Rheumatology, University Hospital Tübingen, Tübingen; Department of Internal Medicine, Division of Rheumatology, Heidelberg University Hospital; Division of Immunogenetics, German Cancer Research Center, Heidelberg; Department of Rheumatology and Clinical Immunology, University Medical Center, Freiburg; Department of Rheumatology and Clinical Immunology, University of Giessen, Kerckhoff Clinic, Bad Nauheim; Department of Dermatology, HELIOS St. Elisabeth Clinic, Oberhausen; Department of Dermatology, St. Joseph Hospital, Ruhr- University of Bochum, Bochum; Department of Dermatology, University Hospital Carl Gustav Carus, Dresden; Department of Rheumatology, Johanniter-Hospital, Treuenbrietzen; Department of Dermatology, Ulm University Hospital, Ulm; Department of Dermatology, University Hospital Regensburg, Regensburg; Department of Rheumatology, Clinic of Rheumatology of Aachen, Aachen; Department of Dermatology, University Hospital Leipzig, Leipzig; Department of Rheumatology, and Department of Dermatology, University Hospital Erlangen, Erlangen; Department of Dermatology, TUM University Hospital; Department of Dermatology, Ludwig Maximilian University, Munich; Department of Rheumatology and Nephrology, University Hospital Duesseldorf, Duesseldorf; Department of Dermatology, University Hospital Göttingen, Göttingen; Department of Dermatology, University Medical Center, Johannes Gutenberg University, Mainz; Clinic for Dermatology, Hamburg Alstertal; Department of Dermatology, Helios Clinic, Wuppertal; Center for Rheumatology Bad Doberan, Bad Doberan; Center for Rheumatology Acura, Baden-Baden; Department of Dermatology, University Hospital of Würzburg, Würzburg; Department of Rheumatology, University Hospital Frankfurt, Frankfurt; Center for Rheumatology (Rehabilitation), Rheinfelden; Clinic for Internal Medicine, Klinikum Stephansplatz; Department of Rheumatology, Asklepios Clinic Altona, Hamburg; Department of Rheumatology, GRP-Hospital Ruesselheim, Darmstadt; Department of Dermatology and Venereology, University Hospital Muenster, Muenster, Germany; Department of Dermatology, Medical University of Graz, Graz, Austria. Supported by a grant of the German Federal Ministry of Education and Research (BMBF; 01GM0310 NH, TK; 01GM0631 CS) and the Edith Busch Foundation. The work of Pia Moinzadeh was supported by “Koeln Fortune” (155/2014) and “Deutsche Stiftung Sklerodermie” (3649/0096/31) grants. P. Moinzadeh, MD, Department of Dermatology, University Hospital of Cologne; G. Riemekasten, MD, Department of Rheumatology, University Medical Center Schleswig-Holstein; E. Siegert, Department of Rheumatology and Clinical Immunology, University of Berlin, Charité; G. Fierlbeck, MD, Department of Dermatology, University Hospital Tübingen; J. Henes, MD, Department of Rheumatology, University Hospital Tübingen; N. Blank, MD, Department of Internal Medicine, Division of Rheumatology, Heidelberg University Hospital; I. Melchers, MD, Department of Rheumatology and Clinical Immunology, University Medical Center; U. Mueller-Ladner, MD, Department of Rheumatology and Clinical Immunology, University of Giessen, Kerckhoff Clinic; M. Frerix, MD, Department of Rheumatology and Clinical Immunology, University of Giessen, Kerckhoff Clinic; A. Kreuter, MD, Department of Dermatology, HELIOS St. Elisabeth Clinic; C. Tigges, MD, Department of Dermatology, HELIOS St. Elisabeth Clinic; N. Lahner, MD, Department of Dermatology, St. Joseph Hospital, Ruhr-University of Bochum; L. Susok, MD, Department of Dermatology, St. Joseph Hospital, Ruhr-University of Bochum; C. Guenther, MD, Department of Dermatology, University Hospital Carl Gustav Carus; G. Zeidler, MD, Department of Rheumatology, Johanniter-Hospital; C. Pfeiffer, MD, Department of Dermatology, Ulm University Hospital; M. Worm, MD, Department of Dermatology, University of Berlin, Charité; S. Karrer, MD, Department of Dermatology, University Hospital Regensburg; E. Aberer, MD, Department of Dermatology, Medical University of Graz; A. Bretterklieber, MD, Department of Dermatology, Medical University of Graz; E. Genth, MD, Department of Rheumatology, Clinic of Rheumatology of Aachen; J.C. Simon, MD, Department of Dermatology, University Hospital Leipzig; J.H. Distler, MD, Department of Rheumatology, University Hospital Erlangen; R. Hein, MD, Department of Dermatology, TUM University Hospital; M. Schneider, MD, Department of Rheumatology and Nephrology, University Hospital Duesseldorf; C.S. Seitz, MD, Department of Dermatology, University Hospital Göttingen; C. Herink, MD, Department of Dermatology, University Hospital Göttingen; K. Steinbrink, MD, Department of Dermatology, University Medical Center, Johannes Gutenberg University; M. Sárdy, MD, Department of Dermatology, Ludwig Maximilian University; R. Varga, MD, Department of Dermatology, Ludwig Maximilian University; H. Mensing, MD, Clinic for Dermatology; C. Mensing, MD, Clinic for Dermatology; P. Lehmann, MD, Department of Dermatology, Helios Clinic; G. Neeck, MD, Center for Rheumatology Bad Doberan; C. Fiehn, MD, Center for Rheumatology Acura; M. Weber, MD, Department of Internal Medicine, Hospital of Cologne Merheim; M. Goebeler, MD, Department of Dermatology, University Hospital of Würzburg; H. Burkhardt, MD, Department of Rheumatology, University Hospital Frankfurt; M. Buslau, MD, Center for Rheumatology (Rehabilitation); K. Ahmadi-Simab, MD, Clinic for Internal Medicine, Klinikum Stephansplatz; A. Himsel, MD, Department of Rheumatology, GRP-Hospital Ruesselheim; A. Juche, MD, Department of Rheumatology, Immanuel Hospital; I. Koetter, MD, Department of Rheumatology, Asklepios Clinic Altona; A. Kuhn, MD, Division of Immunogenetics, German Cancer Research Center; M. Sticherling, MD, Department of Dermatology, University Hospital Erlangen; M. Hellmich, MD, Institute of Medical Statistics, Informatics and Epidemiology, University of Cologne; K. Kuhr, MD, Institute of Medical Statistics, Informatics and Epidemiology, University of Cologne; T. Krieg, MD, Department of Dermatology, University Hospital of Cologne; J. Ehrchen, MD, Department of Dermatology and Venereology, University Hospital Muenster; C. Sunderkoetter, MD, Department of Dermatology and Venereology, University Hospital Muenster; N. Hunzelmann, MD, Department of Dermatology, University Hospital of Cologne. Address correspondence to Dr. P. Moinzadeh, Department of Dermatology and Venereology, University of Cologne, Kerpener Str. 62, 50937 Cologne, Germany. E-mail: pia.moinzadeh@uk-koeln.de. Accepted for publication August 28, 2015.
Miklos Sárdy
From the Department of Dermatology, University Hospital of Cologne; Department of Internal Medicine, Hospital of Cologne Merheim; Institute of Medical Statistics, Informatics and Epidemiology, University of Cologne, Cologne; Department of Rheumatology, University Medical Center Schleswig-Holstein, Lübeck; Department of Rheumatology and Clinical Immunology, and Department of Dermatology, University of Berlin, Charité, Berlin; Department of Rheumatology, Immanuel Hospital, Berlin-Buch; Department of Dermatology, and Department of Rheumatology, University Hospital Tübingen, Tübingen; Department of Internal Medicine, Division of Rheumatology, Heidelberg University Hospital; Division of Immunogenetics, German Cancer Research Center, Heidelberg; Department of Rheumatology and Clinical Immunology, University Medical Center, Freiburg; Department of Rheumatology and Clinical Immunology, University of Giessen, Kerckhoff Clinic, Bad Nauheim; Department of Dermatology, HELIOS St. Elisabeth Clinic, Oberhausen; Department of Dermatology, St. Joseph Hospital, Ruhr- University of Bochum, Bochum; Department of Dermatology, University Hospital Carl Gustav Carus, Dresden; Department of Rheumatology, Johanniter-Hospital, Treuenbrietzen; Department of Dermatology, Ulm University Hospital, Ulm; Department of Dermatology, University Hospital Regensburg, Regensburg; Department of Rheumatology, Clinic of Rheumatology of Aachen, Aachen; Department of Dermatology, University Hospital Leipzig, Leipzig; Department of Rheumatology, and Department of Dermatology, University Hospital Erlangen, Erlangen; Department of Dermatology, TUM University Hospital; Department of Dermatology, Ludwig Maximilian University, Munich; Department of Rheumatology and Nephrology, University Hospital Duesseldorf, Duesseldorf; Department of Dermatology, University Hospital Göttingen, Göttingen; Department of Dermatology, University Medical Center, Johannes Gutenberg University, Mainz; Clinic for Dermatology, Hamburg Alstertal; Department of Dermatology, Helios Clinic, Wuppertal; Center for Rheumatology Bad Doberan, Bad Doberan; Center for Rheumatology Acura, Baden-Baden; Department of Dermatology, University Hospital of Würzburg, Würzburg; Department of Rheumatology, University Hospital Frankfurt, Frankfurt; Center for Rheumatology (Rehabilitation), Rheinfelden; Clinic for Internal Medicine, Klinikum Stephansplatz; Department of Rheumatology, Asklepios Clinic Altona, Hamburg; Department of Rheumatology, GRP-Hospital Ruesselheim, Darmstadt; Department of Dermatology and Venereology, University Hospital Muenster, Muenster, Germany; Department of Dermatology, Medical University of Graz, Graz, Austria. Supported by a grant of the German Federal Ministry of Education and Research (BMBF; 01GM0310 NH, TK; 01GM0631 CS) and the Edith Busch Foundation. The work of Pia Moinzadeh was supported by “Koeln Fortune” (155/2014) and “Deutsche Stiftung Sklerodermie” (3649/0096/31) grants. P. Moinzadeh, MD, Department of Dermatology, University Hospital of Cologne; G. Riemekasten, MD, Department of Rheumatology, University Medical Center Schleswig-Holstein; E. Siegert, Department of Rheumatology and Clinical Immunology, University of Berlin, Charité; G. Fierlbeck, MD, Department of Dermatology, University Hospital Tübingen; J. Henes, MD, Department of Rheumatology, University Hospital Tübingen; N. Blank, MD, Department of Internal Medicine, Division of Rheumatology, Heidelberg University Hospital; I. Melchers, MD, Department of Rheumatology and Clinical Immunology, University Medical Center; U. Mueller-Ladner, MD, Department of Rheumatology and Clinical Immunology, University of Giessen, Kerckhoff Clinic; M. Frerix, MD, Department of Rheumatology and Clinical Immunology, University of Giessen, Kerckhoff Clinic; A. Kreuter, MD, Department of Dermatology, HELIOS St. Elisabeth Clinic; C. Tigges, MD, Department of Dermatology, HELIOS St. Elisabeth Clinic; N. Lahner, MD, Department of Dermatology, St. Joseph Hospital, Ruhr-University of Bochum; L. Susok, MD, Department of Dermatology, St. Joseph Hospital, Ruhr-University of Bochum; C. Guenther, MD, Department of Dermatology, University Hospital Carl Gustav Carus; G. Zeidler, MD, Department of Rheumatology, Johanniter-Hospital; C. Pfeiffer, MD, Department of Dermatology, Ulm University Hospital; M. Worm, MD, Department of Dermatology, University of Berlin, Charité; S. Karrer, MD, Department of Dermatology, University Hospital Regensburg; E. Aberer, MD, Department of Dermatology, Medical University of Graz; A. Bretterklieber, MD, Department of Dermatology, Medical University of Graz; E. Genth, MD, Department of Rheumatology, Clinic of Rheumatology of Aachen; J.C. Simon, MD, Department of Dermatology, University Hospital Leipzig; J.H. Distler, MD, Department of Rheumatology, University Hospital Erlangen; R. Hein, MD, Department of Dermatology, TUM University Hospital; M. Schneider, MD, Department of Rheumatology and Nephrology, University Hospital Duesseldorf; C.S. Seitz, MD, Department of Dermatology, University Hospital Göttingen; C. Herink, MD, Department of Dermatology, University Hospital Göttingen; K. Steinbrink, MD, Department of Dermatology, University Medical Center, Johannes Gutenberg University; M. Sárdy, MD, Department of Dermatology, Ludwig Maximilian University; R. Varga, MD, Department of Dermatology, Ludwig Maximilian University; H. Mensing, MD, Clinic for Dermatology; C. Mensing, MD, Clinic for Dermatology; P. Lehmann, MD, Department of Dermatology, Helios Clinic; G. Neeck, MD, Center for Rheumatology Bad Doberan; C. Fiehn, MD, Center for Rheumatology Acura; M. Weber, MD, Department of Internal Medicine, Hospital of Cologne Merheim; M. Goebeler, MD, Department of Dermatology, University Hospital of Würzburg; H. Burkhardt, MD, Department of Rheumatology, University Hospital Frankfurt; M. Buslau, MD, Center for Rheumatology (Rehabilitation); K. Ahmadi-Simab, MD, Clinic for Internal Medicine, Klinikum Stephansplatz; A. Himsel, MD, Department of Rheumatology, GRP-Hospital Ruesselheim; A. Juche, MD, Department of Rheumatology, Immanuel Hospital; I. Koetter, MD, Department of Rheumatology, Asklepios Clinic Altona; A. Kuhn, MD, Division of Immunogenetics, German Cancer Research Center; M. Sticherling, MD, Department of Dermatology, University Hospital Erlangen; M. Hellmich, MD, Institute of Medical Statistics, Informatics and Epidemiology, University of Cologne; K. Kuhr, MD, Institute of Medical Statistics, Informatics and Epidemiology, University of Cologne; T. Krieg, MD, Department of Dermatology, University Hospital of Cologne; J. Ehrchen, MD, Department of Dermatology and Venereology, University Hospital Muenster; C. Sunderkoetter, MD, Department of Dermatology and Venereology, University Hospital Muenster; N. Hunzelmann, MD, Department of Dermatology, University Hospital of Cologne. Address correspondence to Dr. P. Moinzadeh, Department of Dermatology and Venereology, University of Cologne, Kerpener Str. 62, 50937 Cologne, Germany. E-mail: pia.moinzadeh@uk-koeln.de. Accepted for publication August 28, 2015.
Rita Varga
From the Department of Dermatology, University Hospital of Cologne; Department of Internal Medicine, Hospital of Cologne Merheim; Institute of Medical Statistics, Informatics and Epidemiology, University of Cologne, Cologne; Department of Rheumatology, University Medical Center Schleswig-Holstein, Lübeck; Department of Rheumatology and Clinical Immunology, and Department of Dermatology, University of Berlin, Charité, Berlin; Department of Rheumatology, Immanuel Hospital, Berlin-Buch; Department of Dermatology, and Department of Rheumatology, University Hospital Tübingen, Tübingen; Department of Internal Medicine, Division of Rheumatology, Heidelberg University Hospital; Division of Immunogenetics, German Cancer Research Center, Heidelberg; Department of Rheumatology and Clinical Immunology, University Medical Center, Freiburg; Department of Rheumatology and Clinical Immunology, University of Giessen, Kerckhoff Clinic, Bad Nauheim; Department of Dermatology, HELIOS St. Elisabeth Clinic, Oberhausen; Department of Dermatology, St. Joseph Hospital, Ruhr- University of Bochum, Bochum; Department of Dermatology, University Hospital Carl Gustav Carus, Dresden; Department of Rheumatology, Johanniter-Hospital, Treuenbrietzen; Department of Dermatology, Ulm University Hospital, Ulm; Department of Dermatology, University Hospital Regensburg, Regensburg; Department of Rheumatology, Clinic of Rheumatology of Aachen, Aachen; Department of Dermatology, University Hospital Leipzig, Leipzig; Department of Rheumatology, and Department of Dermatology, University Hospital Erlangen, Erlangen; Department of Dermatology, TUM University Hospital; Department of Dermatology, Ludwig Maximilian University, Munich; Department of Rheumatology and Nephrology, University Hospital Duesseldorf, Duesseldorf; Department of Dermatology, University Hospital Göttingen, Göttingen; Department of Dermatology, University Medical Center, Johannes Gutenberg University, Mainz; Clinic for Dermatology, Hamburg Alstertal; Department of Dermatology, Helios Clinic, Wuppertal; Center for Rheumatology Bad Doberan, Bad Doberan; Center for Rheumatology Acura, Baden-Baden; Department of Dermatology, University Hospital of Würzburg, Würzburg; Department of Rheumatology, University Hospital Frankfurt, Frankfurt; Center for Rheumatology (Rehabilitation), Rheinfelden; Clinic for Internal Medicine, Klinikum Stephansplatz; Department of Rheumatology, Asklepios Clinic Altona, Hamburg; Department of Rheumatology, GRP-Hospital Ruesselheim, Darmstadt; Department of Dermatology and Venereology, University Hospital Muenster, Muenster, Germany; Department of Dermatology, Medical University of Graz, Graz, Austria. Supported by a grant of the German Federal Ministry of Education and Research (BMBF; 01GM0310 NH, TK; 01GM0631 CS) and the Edith Busch Foundation. The work of Pia Moinzadeh was supported by “Koeln Fortune” (155/2014) and “Deutsche Stiftung Sklerodermie” (3649/0096/31) grants. P. Moinzadeh, MD, Department of Dermatology, University Hospital of Cologne; G. Riemekasten, MD, Department of Rheumatology, University Medical Center Schleswig-Holstein; E. Siegert, Department of Rheumatology and Clinical Immunology, University of Berlin, Charité; G. Fierlbeck, MD, Department of Dermatology, University Hospital Tübingen; J. Henes, MD, Department of Rheumatology, University Hospital Tübingen; N. Blank, MD, Department of Internal Medicine, Division of Rheumatology, Heidelberg University Hospital; I. Melchers, MD, Department of Rheumatology and Clinical Immunology, University Medical Center; U. Mueller-Ladner, MD, Department of Rheumatology and Clinical Immunology, University of Giessen, Kerckhoff Clinic; M. Frerix, MD, Department of Rheumatology and Clinical Immunology, University of Giessen, Kerckhoff Clinic; A. Kreuter, MD, Department of Dermatology, HELIOS St. Elisabeth Clinic; C. Tigges, MD, Department of Dermatology, HELIOS St. Elisabeth Clinic; N. Lahner, MD, Department of Dermatology, St. Joseph Hospital, Ruhr-University of Bochum; L. Susok, MD, Department of Dermatology, St. Joseph Hospital, Ruhr-University of Bochum; C. Guenther, MD, Department of Dermatology, University Hospital Carl Gustav Carus; G. Zeidler, MD, Department of Rheumatology, Johanniter-Hospital; C. Pfeiffer, MD, Department of Dermatology, Ulm University Hospital; M. Worm, MD, Department of Dermatology, University of Berlin, Charité; S. Karrer, MD, Department of Dermatology, University Hospital Regensburg; E. Aberer, MD, Department of Dermatology, Medical University of Graz; A. Bretterklieber, MD, Department of Dermatology, Medical University of Graz; E. Genth, MD, Department of Rheumatology, Clinic of Rheumatology of Aachen; J.C. Simon, MD, Department of Dermatology, University Hospital Leipzig; J.H. Distler, MD, Department of Rheumatology, University Hospital Erlangen; R. Hein, MD, Department of Dermatology, TUM University Hospital; M. Schneider, MD, Department of Rheumatology and Nephrology, University Hospital Duesseldorf; C.S. Seitz, MD, Department of Dermatology, University Hospital Göttingen; C. Herink, MD, Department of Dermatology, University Hospital Göttingen; K. Steinbrink, MD, Department of Dermatology, University Medical Center, Johannes Gutenberg University; M. Sárdy, MD, Department of Dermatology, Ludwig Maximilian University; R. Varga, MD, Department of Dermatology, Ludwig Maximilian University; H. Mensing, MD, Clinic for Dermatology; C. Mensing, MD, Clinic for Dermatology; P. Lehmann, MD, Department of Dermatology, Helios Clinic; G. Neeck, MD, Center for Rheumatology Bad Doberan; C. Fiehn, MD, Center for Rheumatology Acura; M. Weber, MD, Department of Internal Medicine, Hospital of Cologne Merheim; M. Goebeler, MD, Department of Dermatology, University Hospital of Würzburg; H. Burkhardt, MD, Department of Rheumatology, University Hospital Frankfurt; M. Buslau, MD, Center for Rheumatology (Rehabilitation); K. Ahmadi-Simab, MD, Clinic for Internal Medicine, Klinikum Stephansplatz; A. Himsel, MD, Department of Rheumatology, GRP-Hospital Ruesselheim; A. Juche, MD, Department of Rheumatology, Immanuel Hospital; I. Koetter, MD, Department of Rheumatology, Asklepios Clinic Altona; A. Kuhn, MD, Division of Immunogenetics, German Cancer Research Center; M. Sticherling, MD, Department of Dermatology, University Hospital Erlangen; M. Hellmich, MD, Institute of Medical Statistics, Informatics and Epidemiology, University of Cologne; K. Kuhr, MD, Institute of Medical Statistics, Informatics and Epidemiology, University of Cologne; T. Krieg, MD, Department of Dermatology, University Hospital of Cologne; J. Ehrchen, MD, Department of Dermatology and Venereology, University Hospital Muenster; C. Sunderkoetter, MD, Department of Dermatology and Venereology, University Hospital Muenster; N. Hunzelmann, MD, Department of Dermatology, University Hospital of Cologne. Address correspondence to Dr. P. Moinzadeh, Department of Dermatology and Venereology, University of Cologne, Kerpener Str. 62, 50937 Cologne, Germany. E-mail: pia.moinzadeh@uk-koeln.de. Accepted for publication August 28, 2015.
Hartwig Mensing
From the Department of Dermatology, University Hospital of Cologne; Department of Internal Medicine, Hospital of Cologne Merheim; Institute of Medical Statistics, Informatics and Epidemiology, University of Cologne, Cologne; Department of Rheumatology, University Medical Center Schleswig-Holstein, Lübeck; Department of Rheumatology and Clinical Immunology, and Department of Dermatology, University of Berlin, Charité, Berlin; Department of Rheumatology, Immanuel Hospital, Berlin-Buch; Department of Dermatology, and Department of Rheumatology, University Hospital Tübingen, Tübingen; Department of Internal Medicine, Division of Rheumatology, Heidelberg University Hospital; Division of Immunogenetics, German Cancer Research Center, Heidelberg; Department of Rheumatology and Clinical Immunology, University Medical Center, Freiburg; Department of Rheumatology and Clinical Immunology, University of Giessen, Kerckhoff Clinic, Bad Nauheim; Department of Dermatology, HELIOS St. Elisabeth Clinic, Oberhausen; Department of Dermatology, St. Joseph Hospital, Ruhr- University of Bochum, Bochum; Department of Dermatology, University Hospital Carl Gustav Carus, Dresden; Department of Rheumatology, Johanniter-Hospital, Treuenbrietzen; Department of Dermatology, Ulm University Hospital, Ulm; Department of Dermatology, University Hospital Regensburg, Regensburg; Department of Rheumatology, Clinic of Rheumatology of Aachen, Aachen; Department of Dermatology, University Hospital Leipzig, Leipzig; Department of Rheumatology, and Department of Dermatology, University Hospital Erlangen, Erlangen; Department of Dermatology, TUM University Hospital; Department of Dermatology, Ludwig Maximilian University, Munich; Department of Rheumatology and Nephrology, University Hospital Duesseldorf, Duesseldorf; Department of Dermatology, University Hospital Göttingen, Göttingen; Department of Dermatology, University Medical Center, Johannes Gutenberg University, Mainz; Clinic for Dermatology, Hamburg Alstertal; Department of Dermatology, Helios Clinic, Wuppertal; Center for Rheumatology Bad Doberan, Bad Doberan; Center for Rheumatology Acura, Baden-Baden; Department of Dermatology, University Hospital of Würzburg, Würzburg; Department of Rheumatology, University Hospital Frankfurt, Frankfurt; Center for Rheumatology (Rehabilitation), Rheinfelden; Clinic for Internal Medicine, Klinikum Stephansplatz; Department of Rheumatology, Asklepios Clinic Altona, Hamburg; Department of Rheumatology, GRP-Hospital Ruesselheim, Darmstadt; Department of Dermatology and Venereology, University Hospital Muenster, Muenster, Germany; Department of Dermatology, Medical University of Graz, Graz, Austria. Supported by a grant of the German Federal Ministry of Education and Research (BMBF; 01GM0310 NH, TK; 01GM0631 CS) and the Edith Busch Foundation. The work of Pia Moinzadeh was supported by “Koeln Fortune” (155/2014) and “Deutsche Stiftung Sklerodermie” (3649/0096/31) grants. P. Moinzadeh, MD, Department of Dermatology, University Hospital of Cologne; G. Riemekasten, MD, Department of Rheumatology, University Medical Center Schleswig-Holstein; E. Siegert, Department of Rheumatology and Clinical Immunology, University of Berlin, Charité; G. Fierlbeck, MD, Department of Dermatology, University Hospital Tübingen; J. Henes, MD, Department of Rheumatology, University Hospital Tübingen; N. Blank, MD, Department of Internal Medicine, Division of Rheumatology, Heidelberg University Hospital; I. Melchers, MD, Department of Rheumatology and Clinical Immunology, University Medical Center; U. Mueller-Ladner, MD, Department of Rheumatology and Clinical Immunology, University of Giessen, Kerckhoff Clinic; M. Frerix, MD, Department of Rheumatology and Clinical Immunology, University of Giessen, Kerckhoff Clinic; A. Kreuter, MD, Department of Dermatology, HELIOS St. Elisabeth Clinic; C. Tigges, MD, Department of Dermatology, HELIOS St. Elisabeth Clinic; N. Lahner, MD, Department of Dermatology, St. Joseph Hospital, Ruhr-University of Bochum; L. Susok, MD, Department of Dermatology, St. Joseph Hospital, Ruhr-University of Bochum; C. Guenther, MD, Department of Dermatology, University Hospital Carl Gustav Carus; G. Zeidler, MD, Department of Rheumatology, Johanniter-Hospital; C. Pfeiffer, MD, Department of Dermatology, Ulm University Hospital; M. Worm, MD, Department of Dermatology, University of Berlin, Charité; S. Karrer, MD, Department of Dermatology, University Hospital Regensburg; E. Aberer, MD, Department of Dermatology, Medical University of Graz; A. Bretterklieber, MD, Department of Dermatology, Medical University of Graz; E. Genth, MD, Department of Rheumatology, Clinic of Rheumatology of Aachen; J.C. Simon, MD, Department of Dermatology, University Hospital Leipzig; J.H. Distler, MD, Department of Rheumatology, University Hospital Erlangen; R. Hein, MD, Department of Dermatology, TUM University Hospital; M. Schneider, MD, Department of Rheumatology and Nephrology, University Hospital Duesseldorf; C.S. Seitz, MD, Department of Dermatology, University Hospital Göttingen; C. Herink, MD, Department of Dermatology, University Hospital Göttingen; K. Steinbrink, MD, Department of Dermatology, University Medical Center, Johannes Gutenberg University; M. Sárdy, MD, Department of Dermatology, Ludwig Maximilian University; R. Varga, MD, Department of Dermatology, Ludwig Maximilian University; H. Mensing, MD, Clinic for Dermatology; C. Mensing, MD, Clinic for Dermatology; P. Lehmann, MD, Department of Dermatology, Helios Clinic; G. Neeck, MD, Center for Rheumatology Bad Doberan; C. Fiehn, MD, Center for Rheumatology Acura; M. Weber, MD, Department of Internal Medicine, Hospital of Cologne Merheim; M. Goebeler, MD, Department of Dermatology, University Hospital of Würzburg; H. Burkhardt, MD, Department of Rheumatology, University Hospital Frankfurt; M. Buslau, MD, Center for Rheumatology (Rehabilitation); K. Ahmadi-Simab, MD, Clinic for Internal Medicine, Klinikum Stephansplatz; A. Himsel, MD, Department of Rheumatology, GRP-Hospital Ruesselheim; A. Juche, MD, Department of Rheumatology, Immanuel Hospital; I. Koetter, MD, Department of Rheumatology, Asklepios Clinic Altona; A. Kuhn, MD, Division of Immunogenetics, German Cancer Research Center; M. Sticherling, MD, Department of Dermatology, University Hospital Erlangen; M. Hellmich, MD, Institute of Medical Statistics, Informatics and Epidemiology, University of Cologne; K. Kuhr, MD, Institute of Medical Statistics, Informatics and Epidemiology, University of Cologne; T. Krieg, MD, Department of Dermatology, University Hospital of Cologne; J. Ehrchen, MD, Department of Dermatology and Venereology, University Hospital Muenster; C. Sunderkoetter, MD, Department of Dermatology and Venereology, University Hospital Muenster; N. Hunzelmann, MD, Department of Dermatology, University Hospital of Cologne. Address correspondence to Dr. P. Moinzadeh, Department of Dermatology and Venereology, University of Cologne, Kerpener Str. 62, 50937 Cologne, Germany. E-mail: pia.moinzadeh@uk-koeln.de. Accepted for publication August 28, 2015.
Christian Mensing
From the Department of Dermatology, University Hospital of Cologne; Department of Internal Medicine, Hospital of Cologne Merheim; Institute of Medical Statistics, Informatics and Epidemiology, University of Cologne, Cologne; Department of Rheumatology, University Medical Center Schleswig-Holstein, Lübeck; Department of Rheumatology and Clinical Immunology, and Department of Dermatology, University of Berlin, Charité, Berlin; Department of Rheumatology, Immanuel Hospital, Berlin-Buch; Department of Dermatology, and Department of Rheumatology, University Hospital Tübingen, Tübingen; Department of Internal Medicine, Division of Rheumatology, Heidelberg University Hospital; Division of Immunogenetics, German Cancer Research Center, Heidelberg; Department of Rheumatology and Clinical Immunology, University Medical Center, Freiburg; Department of Rheumatology and Clinical Immunology, University of Giessen, Kerckhoff Clinic, Bad Nauheim; Department of Dermatology, HELIOS St. Elisabeth Clinic, Oberhausen; Department of Dermatology, St. Joseph Hospital, Ruhr- University of Bochum, Bochum; Department of Dermatology, University Hospital Carl Gustav Carus, Dresden; Department of Rheumatology, Johanniter-Hospital, Treuenbrietzen; Department of Dermatology, Ulm University Hospital, Ulm; Department of Dermatology, University Hospital Regensburg, Regensburg; Department of Rheumatology, Clinic of Rheumatology of Aachen, Aachen; Department of Dermatology, University Hospital Leipzig, Leipzig; Department of Rheumatology, and Department of Dermatology, University Hospital Erlangen, Erlangen; Department of Dermatology, TUM University Hospital; Department of Dermatology, Ludwig Maximilian University, Munich; Department of Rheumatology and Nephrology, University Hospital Duesseldorf, Duesseldorf; Department of Dermatology, University Hospital Göttingen, Göttingen; Department of Dermatology, University Medical Center, Johannes Gutenberg University, Mainz; Clinic for Dermatology, Hamburg Alstertal; Department of Dermatology, Helios Clinic, Wuppertal; Center for Rheumatology Bad Doberan, Bad Doberan; Center for Rheumatology Acura, Baden-Baden; Department of Dermatology, University Hospital of Würzburg, Würzburg; Department of Rheumatology, University Hospital Frankfurt, Frankfurt; Center for Rheumatology (Rehabilitation), Rheinfelden; Clinic for Internal Medicine, Klinikum Stephansplatz; Department of Rheumatology, Asklepios Clinic Altona, Hamburg; Department of Rheumatology, GRP-Hospital Ruesselheim, Darmstadt; Department of Dermatology and Venereology, University Hospital Muenster, Muenster, Germany; Department of Dermatology, Medical University of Graz, Graz, Austria. Supported by a grant of the German Federal Ministry of Education and Research (BMBF; 01GM0310 NH, TK; 01GM0631 CS) and the Edith Busch Foundation. The work of Pia Moinzadeh was supported by “Koeln Fortune” (155/2014) and “Deutsche Stiftung Sklerodermie” (3649/0096/31) grants. P. Moinzadeh, MD, Department of Dermatology, University Hospital of Cologne; G. Riemekasten, MD, Department of Rheumatology, University Medical Center Schleswig-Holstein; E. Siegert, Department of Rheumatology and Clinical Immunology, University of Berlin, Charité; G. Fierlbeck, MD, Department of Dermatology, University Hospital Tübingen; J. Henes, MD, Department of Rheumatology, University Hospital Tübingen; N. Blank, MD, Department of Internal Medicine, Division of Rheumatology, Heidelberg University Hospital; I. Melchers, MD, Department of Rheumatology and Clinical Immunology, University Medical Center; U. Mueller-Ladner, MD, Department of Rheumatology and Clinical Immunology, University of Giessen, Kerckhoff Clinic; M. Frerix, MD, Department of Rheumatology and Clinical Immunology, University of Giessen, Kerckhoff Clinic; A. Kreuter, MD, Department of Dermatology, HELIOS St. Elisabeth Clinic; C. Tigges, MD, Department of Dermatology, HELIOS St. Elisabeth Clinic; N. Lahner, MD, Department of Dermatology, St. Joseph Hospital, Ruhr-University of Bochum; L. Susok, MD, Department of Dermatology, St. Joseph Hospital, Ruhr-University of Bochum; C. Guenther, MD, Department of Dermatology, University Hospital Carl Gustav Carus; G. Zeidler, MD, Department of Rheumatology, Johanniter-Hospital; C. Pfeiffer, MD, Department of Dermatology, Ulm University Hospital; M. Worm, MD, Department of Dermatology, University of Berlin, Charité; S. Karrer, MD, Department of Dermatology, University Hospital Regensburg; E. Aberer, MD, Department of Dermatology, Medical University of Graz; A. Bretterklieber, MD, Department of Dermatology, Medical University of Graz; E. Genth, MD, Department of Rheumatology, Clinic of Rheumatology of Aachen; J.C. Simon, MD, Department of Dermatology, University Hospital Leipzig; J.H. Distler, MD, Department of Rheumatology, University Hospital Erlangen; R. Hein, MD, Department of Dermatology, TUM University Hospital; M. Schneider, MD, Department of Rheumatology and Nephrology, University Hospital Duesseldorf; C.S. Seitz, MD, Department of Dermatology, University Hospital Göttingen; C. Herink, MD, Department of Dermatology, University Hospital Göttingen; K. Steinbrink, MD, Department of Dermatology, University Medical Center, Johannes Gutenberg University; M. Sárdy, MD, Department of Dermatology, Ludwig Maximilian University; R. Varga, MD, Department of Dermatology, Ludwig Maximilian University; H. Mensing, MD, Clinic for Dermatology; C. Mensing, MD, Clinic for Dermatology; P. Lehmann, MD, Department of Dermatology, Helios Clinic; G. Neeck, MD, Center for Rheumatology Bad Doberan; C. Fiehn, MD, Center for Rheumatology Acura; M. Weber, MD, Department of Internal Medicine, Hospital of Cologne Merheim; M. Goebeler, MD, Department of Dermatology, University Hospital of Würzburg; H. Burkhardt, MD, Department of Rheumatology, University Hospital Frankfurt; M. Buslau, MD, Center for Rheumatology (Rehabilitation); K. Ahmadi-Simab, MD, Clinic for Internal Medicine, Klinikum Stephansplatz; A. Himsel, MD, Department of Rheumatology, GRP-Hospital Ruesselheim; A. Juche, MD, Department of Rheumatology, Immanuel Hospital; I. Koetter, MD, Department of Rheumatology, Asklepios Clinic Altona; A. Kuhn, MD, Division of Immunogenetics, German Cancer Research Center; M. Sticherling, MD, Department of Dermatology, University Hospital Erlangen; M. Hellmich, MD, Institute of Medical Statistics, Informatics and Epidemiology, University of Cologne; K. Kuhr, MD, Institute of Medical Statistics, Informatics and Epidemiology, University of Cologne; T. Krieg, MD, Department of Dermatology, University Hospital of Cologne; J. Ehrchen, MD, Department of Dermatology and Venereology, University Hospital Muenster; C. Sunderkoetter, MD, Department of Dermatology and Venereology, University Hospital Muenster; N. Hunzelmann, MD, Department of Dermatology, University Hospital of Cologne. Address correspondence to Dr. P. Moinzadeh, Department of Dermatology and Venereology, University of Cologne, Kerpener Str. 62, 50937 Cologne, Germany. E-mail: pia.moinzadeh@uk-koeln.de. Accepted for publication August 28, 2015.
Percy Lehmann
From the Department of Dermatology, University Hospital of Cologne; Department of Internal Medicine, Hospital of Cologne Merheim; Institute of Medical Statistics, Informatics and Epidemiology, University of Cologne, Cologne; Department of Rheumatology, University Medical Center Schleswig-Holstein, Lübeck; Department of Rheumatology and Clinical Immunology, and Department of Dermatology, University of Berlin, Charité, Berlin; Department of Rheumatology, Immanuel Hospital, Berlin-Buch; Department of Dermatology, and Department of Rheumatology, University Hospital Tübingen, Tübingen; Department of Internal Medicine, Division of Rheumatology, Heidelberg University Hospital; Division of Immunogenetics, German Cancer Research Center, Heidelberg; Department of Rheumatology and Clinical Immunology, University Medical Center, Freiburg; Department of Rheumatology and Clinical Immunology, University of Giessen, Kerckhoff Clinic, Bad Nauheim; Department of Dermatology, HELIOS St. Elisabeth Clinic, Oberhausen; Department of Dermatology, St. Joseph Hospital, Ruhr- University of Bochum, Bochum; Department of Dermatology, University Hospital Carl Gustav Carus, Dresden; Department of Rheumatology, Johanniter-Hospital, Treuenbrietzen; Department of Dermatology, Ulm University Hospital, Ulm; Department of Dermatology, University Hospital Regensburg, Regensburg; Department of Rheumatology, Clinic of Rheumatology of Aachen, Aachen; Department of Dermatology, University Hospital Leipzig, Leipzig; Department of Rheumatology, and Department of Dermatology, University Hospital Erlangen, Erlangen; Department of Dermatology, TUM University Hospital; Department of Dermatology, Ludwig Maximilian University, Munich; Department of Rheumatology and Nephrology, University Hospital Duesseldorf, Duesseldorf; Department of Dermatology, University Hospital Göttingen, Göttingen; Department of Dermatology, University Medical Center, Johannes Gutenberg University, Mainz; Clinic for Dermatology, Hamburg Alstertal; Department of Dermatology, Helios Clinic, Wuppertal; Center for Rheumatology Bad Doberan, Bad Doberan; Center for Rheumatology Acura, Baden-Baden; Department of Dermatology, University Hospital of Würzburg, Würzburg; Department of Rheumatology, University Hospital Frankfurt, Frankfurt; Center for Rheumatology (Rehabilitation), Rheinfelden; Clinic for Internal Medicine, Klinikum Stephansplatz; Department of Rheumatology, Asklepios Clinic Altona, Hamburg; Department of Rheumatology, GRP-Hospital Ruesselheim, Darmstadt; Department of Dermatology and Venereology, University Hospital Muenster, Muenster, Germany; Department of Dermatology, Medical University of Graz, Graz, Austria. Supported by a grant of the German Federal Ministry of Education and Research (BMBF; 01GM0310 NH, TK; 01GM0631 CS) and the Edith Busch Foundation. The work of Pia Moinzadeh was supported by “Koeln Fortune” (155/2014) and “Deutsche Stiftung Sklerodermie” (3649/0096/31) grants. P. Moinzadeh, MD, Department of Dermatology, University Hospital of Cologne; G. Riemekasten, MD, Department of Rheumatology, University Medical Center Schleswig-Holstein; E. Siegert, Department of Rheumatology and Clinical Immunology, University of Berlin, Charité; G. Fierlbeck, MD, Department of Dermatology, University Hospital Tübingen; J. Henes, MD, Department of Rheumatology, University Hospital Tübingen; N. Blank, MD, Department of Internal Medicine, Division of Rheumatology, Heidelberg University Hospital; I. Melchers, MD, Department of Rheumatology and Clinical Immunology, University Medical Center; U. Mueller-Ladner, MD, Department of Rheumatology and Clinical Immunology, University of Giessen, Kerckhoff Clinic; M. Frerix, MD, Department of Rheumatology and Clinical Immunology, University of Giessen, Kerckhoff Clinic; A. Kreuter, MD, Department of Dermatology, HELIOS St. Elisabeth Clinic; C. Tigges, MD, Department of Dermatology, HELIOS St. Elisabeth Clinic; N. Lahner, MD, Department of Dermatology, St. Joseph Hospital, Ruhr-University of Bochum; L. Susok, MD, Department of Dermatology, St. Joseph Hospital, Ruhr-University of Bochum; C. Guenther, MD, Department of Dermatology, University Hospital Carl Gustav Carus; G. Zeidler, MD, Department of Rheumatology, Johanniter-Hospital; C. Pfeiffer, MD, Department of Dermatology, Ulm University Hospital; M. Worm, MD, Department of Dermatology, University of Berlin, Charité; S. Karrer, MD, Department of Dermatology, University Hospital Regensburg; E. Aberer, MD, Department of Dermatology, Medical University of Graz; A. Bretterklieber, MD, Department of Dermatology, Medical University of Graz; E. Genth, MD, Department of Rheumatology, Clinic of Rheumatology of Aachen; J.C. Simon, MD, Department of Dermatology, University Hospital Leipzig; J.H. Distler, MD, Department of Rheumatology, University Hospital Erlangen; R. Hein, MD, Department of Dermatology, TUM University Hospital; M. Schneider, MD, Department of Rheumatology and Nephrology, University Hospital Duesseldorf; C.S. Seitz, MD, Department of Dermatology, University Hospital Göttingen; C. Herink, MD, Department of Dermatology, University Hospital Göttingen; K. Steinbrink, MD, Department of Dermatology, University Medical Center, Johannes Gutenberg University; M. Sárdy, MD, Department of Dermatology, Ludwig Maximilian University; R. Varga, MD, Department of Dermatology, Ludwig Maximilian University; H. Mensing, MD, Clinic for Dermatology; C. Mensing, MD, Clinic for Dermatology; P. Lehmann, MD, Department of Dermatology, Helios Clinic; G. Neeck, MD, Center for Rheumatology Bad Doberan; C. Fiehn, MD, Center for Rheumatology Acura; M. Weber, MD, Department of Internal Medicine, Hospital of Cologne Merheim; M. Goebeler, MD, Department of Dermatology, University Hospital of Würzburg; H. Burkhardt, MD, Department of Rheumatology, University Hospital Frankfurt; M. Buslau, MD, Center for Rheumatology (Rehabilitation); K. Ahmadi-Simab, MD, Clinic for Internal Medicine, Klinikum Stephansplatz; A. Himsel, MD, Department of Rheumatology, GRP-Hospital Ruesselheim; A. Juche, MD, Department of Rheumatology, Immanuel Hospital; I. Koetter, MD, Department of Rheumatology, Asklepios Clinic Altona; A. Kuhn, MD, Division of Immunogenetics, German Cancer Research Center; M. Sticherling, MD, Department of Dermatology, University Hospital Erlangen; M. Hellmich, MD, Institute of Medical Statistics, Informatics and Epidemiology, University of Cologne; K. Kuhr, MD, Institute of Medical Statistics, Informatics and Epidemiology, University of Cologne; T. Krieg, MD, Department of Dermatology, University Hospital of Cologne; J. Ehrchen, MD, Department of Dermatology and Venereology, University Hospital Muenster; C. Sunderkoetter, MD, Department of Dermatology and Venereology, University Hospital Muenster; N. Hunzelmann, MD, Department of Dermatology, University Hospital of Cologne. Address correspondence to Dr. P. Moinzadeh, Department of Dermatology and Venereology, University of Cologne, Kerpener Str. 62, 50937 Cologne, Germany. E-mail: pia.moinzadeh@uk-koeln.de. Accepted for publication August 28, 2015.
Gunther Neeck
From the Department of Dermatology, University Hospital of Cologne; Department of Internal Medicine, Hospital of Cologne Merheim; Institute of Medical Statistics, Informatics and Epidemiology, University of Cologne, Cologne; Department of Rheumatology, University Medical Center Schleswig-Holstein, Lübeck; Department of Rheumatology and Clinical Immunology, and Department of Dermatology, University of Berlin, Charité, Berlin; Department of Rheumatology, Immanuel Hospital, Berlin-Buch; Department of Dermatology, and Department of Rheumatology, University Hospital Tübingen, Tübingen; Department of Internal Medicine, Division of Rheumatology, Heidelberg University Hospital; Division of Immunogenetics, German Cancer Research Center, Heidelberg; Department of Rheumatology and Clinical Immunology, University Medical Center, Freiburg; Department of Rheumatology and Clinical Immunology, University of Giessen, Kerckhoff Clinic, Bad Nauheim; Department of Dermatology, HELIOS St. Elisabeth Clinic, Oberhausen; Department of Dermatology, St. Joseph Hospital, Ruhr- University of Bochum, Bochum; Department of Dermatology, University Hospital Carl Gustav Carus, Dresden; Department of Rheumatology, Johanniter-Hospital, Treuenbrietzen; Department of Dermatology, Ulm University Hospital, Ulm; Department of Dermatology, University Hospital Regensburg, Regensburg; Department of Rheumatology, Clinic of Rheumatology of Aachen, Aachen; Department of Dermatology, University Hospital Leipzig, Leipzig; Department of Rheumatology, and Department of Dermatology, University Hospital Erlangen, Erlangen; Department of Dermatology, TUM University Hospital; Department of Dermatology, Ludwig Maximilian University, Munich; Department of Rheumatology and Nephrology, University Hospital Duesseldorf, Duesseldorf; Department of Dermatology, University Hospital Göttingen, Göttingen; Department of Dermatology, University Medical Center, Johannes Gutenberg University, Mainz; Clinic for Dermatology, Hamburg Alstertal; Department of Dermatology, Helios Clinic, Wuppertal; Center for Rheumatology Bad Doberan, Bad Doberan; Center for Rheumatology Acura, Baden-Baden; Department of Dermatology, University Hospital of Würzburg, Würzburg; Department of Rheumatology, University Hospital Frankfurt, Frankfurt; Center for Rheumatology (Rehabilitation), Rheinfelden; Clinic for Internal Medicine, Klinikum Stephansplatz; Department of Rheumatology, Asklepios Clinic Altona, Hamburg; Department of Rheumatology, GRP-Hospital Ruesselheim, Darmstadt; Department of Dermatology and Venereology, University Hospital Muenster, Muenster, Germany; Department of Dermatology, Medical University of Graz, Graz, Austria. Supported by a grant of the German Federal Ministry of Education and Research (BMBF; 01GM0310 NH, TK; 01GM0631 CS) and the Edith Busch Foundation. The work of Pia Moinzadeh was supported by “Koeln Fortune” (155/2014) and “Deutsche Stiftung Sklerodermie” (3649/0096/31) grants. P. Moinzadeh, MD, Department of Dermatology, University Hospital of Cologne; G. Riemekasten, MD, Department of Rheumatology, University Medical Center Schleswig-Holstein; E. Siegert, Department of Rheumatology and Clinical Immunology, University of Berlin, Charité; G. Fierlbeck, MD, Department of Dermatology, University Hospital Tübingen; J. Henes, MD, Department of Rheumatology, University Hospital Tübingen; N. Blank, MD, Department of Internal Medicine, Division of Rheumatology, Heidelberg University Hospital; I. Melchers, MD, Department of Rheumatology and Clinical Immunology, University Medical Center; U. Mueller-Ladner, MD, Department of Rheumatology and Clinical Immunology, University of Giessen, Kerckhoff Clinic; M. Frerix, MD, Department of Rheumatology and Clinical Immunology, University of Giessen, Kerckhoff Clinic; A. Kreuter, MD, Department of Dermatology, HELIOS St. Elisabeth Clinic; C. Tigges, MD, Department of Dermatology, HELIOS St. Elisabeth Clinic; N. Lahner, MD, Department of Dermatology, St. Joseph Hospital, Ruhr-University of Bochum; L. Susok, MD, Department of Dermatology, St. Joseph Hospital, Ruhr-University of Bochum; C. Guenther, MD, Department of Dermatology, University Hospital Carl Gustav Carus; G. Zeidler, MD, Department of Rheumatology, Johanniter-Hospital; C. Pfeiffer, MD, Department of Dermatology, Ulm University Hospital; M. Worm, MD, Department of Dermatology, University of Berlin, Charité; S. Karrer, MD, Department of Dermatology, University Hospital Regensburg; E. Aberer, MD, Department of Dermatology, Medical University of Graz; A. Bretterklieber, MD, Department of Dermatology, Medical University of Graz; E. Genth, MD, Department of Rheumatology, Clinic of Rheumatology of Aachen; J.C. Simon, MD, Department of Dermatology, University Hospital Leipzig; J.H. Distler, MD, Department of Rheumatology, University Hospital Erlangen; R. Hein, MD, Department of Dermatology, TUM University Hospital; M. Schneider, MD, Department of Rheumatology and Nephrology, University Hospital Duesseldorf; C.S. Seitz, MD, Department of Dermatology, University Hospital Göttingen; C. Herink, MD, Department of Dermatology, University Hospital Göttingen; K. Steinbrink, MD, Department of Dermatology, University Medical Center, Johannes Gutenberg University; M. Sárdy, MD, Department of Dermatology, Ludwig Maximilian University; R. Varga, MD, Department of Dermatology, Ludwig Maximilian University; H. Mensing, MD, Clinic for Dermatology; C. Mensing, MD, Clinic for Dermatology; P. Lehmann, MD, Department of Dermatology, Helios Clinic; G. Neeck, MD, Center for Rheumatology Bad Doberan; C. Fiehn, MD, Center for Rheumatology Acura; M. Weber, MD, Department of Internal Medicine, Hospital of Cologne Merheim; M. Goebeler, MD, Department of Dermatology, University Hospital of Würzburg; H. Burkhardt, MD, Department of Rheumatology, University Hospital Frankfurt; M. Buslau, MD, Center for Rheumatology (Rehabilitation); K. Ahmadi-Simab, MD, Clinic for Internal Medicine, Klinikum Stephansplatz; A. Himsel, MD, Department of Rheumatology, GRP-Hospital Ruesselheim; A. Juche, MD, Department of Rheumatology, Immanuel Hospital; I. Koetter, MD, Department of Rheumatology, Asklepios Clinic Altona; A. Kuhn, MD, Division of Immunogenetics, German Cancer Research Center; M. Sticherling, MD, Department of Dermatology, University Hospital Erlangen; M. Hellmich, MD, Institute of Medical Statistics, Informatics and Epidemiology, University of Cologne; K. Kuhr, MD, Institute of Medical Statistics, Informatics and Epidemiology, University of Cologne; T. Krieg, MD, Department of Dermatology, University Hospital of Cologne; J. Ehrchen, MD, Department of Dermatology and Venereology, University Hospital Muenster; C. Sunderkoetter, MD, Department of Dermatology and Venereology, University Hospital Muenster; N. Hunzelmann, MD, Department of Dermatology, University Hospital of Cologne. Address correspondence to Dr. P. Moinzadeh, Department of Dermatology and Venereology, University of Cologne, Kerpener Str. 62, 50937 Cologne, Germany. E-mail: pia.moinzadeh@uk-koeln.de. Accepted for publication August 28, 2015.
Christoph Fiehn
From the Department of Dermatology, University Hospital of Cologne; Department of Internal Medicine, Hospital of Cologne Merheim; Institute of Medical Statistics, Informatics and Epidemiology, University of Cologne, Cologne; Department of Rheumatology, University Medical Center Schleswig-Holstein, Lübeck; Department of Rheumatology and Clinical Immunology, and Department of Dermatology, University of Berlin, Charité, Berlin; Department of Rheumatology, Immanuel Hospital, Berlin-Buch; Department of Dermatology, and Department of Rheumatology, University Hospital Tübingen, Tübingen; Department of Internal Medicine, Division of Rheumatology, Heidelberg University Hospital; Division of Immunogenetics, German Cancer Research Center, Heidelberg; Department of Rheumatology and Clinical Immunology, University Medical Center, Freiburg; Department of Rheumatology and Clinical Immunology, University of Giessen, Kerckhoff Clinic, Bad Nauheim; Department of Dermatology, HELIOS St. Elisabeth Clinic, Oberhausen; Department of Dermatology, St. Joseph Hospital, Ruhr- University of Bochum, Bochum; Department of Dermatology, University Hospital Carl Gustav Carus, Dresden; Department of Rheumatology, Johanniter-Hospital, Treuenbrietzen; Department of Dermatology, Ulm University Hospital, Ulm; Department of Dermatology, University Hospital Regensburg, Regensburg; Department of Rheumatology, Clinic of Rheumatology of Aachen, Aachen; Department of Dermatology, University Hospital Leipzig, Leipzig; Department of Rheumatology, and Department of Dermatology, University Hospital Erlangen, Erlangen; Department of Dermatology, TUM University Hospital; Department of Dermatology, Ludwig Maximilian University, Munich; Department of Rheumatology and Nephrology, University Hospital Duesseldorf, Duesseldorf; Department of Dermatology, University Hospital Göttingen, Göttingen; Department of Dermatology, University Medical Center, Johannes Gutenberg University, Mainz; Clinic for Dermatology, Hamburg Alstertal; Department of Dermatology, Helios Clinic, Wuppertal; Center for Rheumatology Bad Doberan, Bad Doberan; Center for Rheumatology Acura, Baden-Baden; Department of Dermatology, University Hospital of Würzburg, Würzburg; Department of Rheumatology, University Hospital Frankfurt, Frankfurt; Center for Rheumatology (Rehabilitation), Rheinfelden; Clinic for Internal Medicine, Klinikum Stephansplatz; Department of Rheumatology, Asklepios Clinic Altona, Hamburg; Department of Rheumatology, GRP-Hospital Ruesselheim, Darmstadt; Department of Dermatology and Venereology, University Hospital Muenster, Muenster, Germany; Department of Dermatology, Medical University of Graz, Graz, Austria. Supported by a grant of the German Federal Ministry of Education and Research (BMBF; 01GM0310 NH, TK; 01GM0631 CS) and the Edith Busch Foundation. The work of Pia Moinzadeh was supported by “Koeln Fortune” (155/2014) and “Deutsche Stiftung Sklerodermie” (3649/0096/31) grants. P. Moinzadeh, MD, Department of Dermatology, University Hospital of Cologne; G. Riemekasten, MD, Department of Rheumatology, University Medical Center Schleswig-Holstein; E. Siegert, Department of Rheumatology and Clinical Immunology, University of Berlin, Charité; G. Fierlbeck, MD, Department of Dermatology, University Hospital Tübingen; J. Henes, MD, Department of Rheumatology, University Hospital Tübingen; N. Blank, MD, Department of Internal Medicine, Division of Rheumatology, Heidelberg University Hospital; I. Melchers, MD, Department of Rheumatology and Clinical Immunology, University Medical Center; U. Mueller-Ladner, MD, Department of Rheumatology and Clinical Immunology, University of Giessen, Kerckhoff Clinic; M. Frerix, MD, Department of Rheumatology and Clinical Immunology, University of Giessen, Kerckhoff Clinic; A. Kreuter, MD, Department of Dermatology, HELIOS St. Elisabeth Clinic; C. Tigges, MD, Department of Dermatology, HELIOS St. Elisabeth Clinic; N. Lahner, MD, Department of Dermatology, St. Joseph Hospital, Ruhr-University of Bochum; L. Susok, MD, Department of Dermatology, St. Joseph Hospital, Ruhr-University of Bochum; C. Guenther, MD, Department of Dermatology, University Hospital Carl Gustav Carus; G. Zeidler, MD, Department of Rheumatology, Johanniter-Hospital; C. Pfeiffer, MD, Department of Dermatology, Ulm University Hospital; M. Worm, MD, Department of Dermatology, University of Berlin, Charité; S. Karrer, MD, Department of Dermatology, University Hospital Regensburg; E. Aberer, MD, Department of Dermatology, Medical University of Graz; A. Bretterklieber, MD, Department of Dermatology, Medical University of Graz; E. Genth, MD, Department of Rheumatology, Clinic of Rheumatology of Aachen; J.C. Simon, MD, Department of Dermatology, University Hospital Leipzig; J.H. Distler, MD, Department of Rheumatology, University Hospital Erlangen; R. Hein, MD, Department of Dermatology, TUM University Hospital; M. Schneider, MD, Department of Rheumatology and Nephrology, University Hospital Duesseldorf; C.S. Seitz, MD, Department of Dermatology, University Hospital Göttingen; C. Herink, MD, Department of Dermatology, University Hospital Göttingen; K. Steinbrink, MD, Department of Dermatology, University Medical Center, Johannes Gutenberg University; M. Sárdy, MD, Department of Dermatology, Ludwig Maximilian University; R. Varga, MD, Department of Dermatology, Ludwig Maximilian University; H. Mensing, MD, Clinic for Dermatology; C. Mensing, MD, Clinic for Dermatology; P. Lehmann, MD, Department of Dermatology, Helios Clinic; G. Neeck, MD, Center for Rheumatology Bad Doberan; C. Fiehn, MD, Center for Rheumatology Acura; M. Weber, MD, Department of Internal Medicine, Hospital of Cologne Merheim; M. Goebeler, MD, Department of Dermatology, University Hospital of Würzburg; H. Burkhardt, MD, Department of Rheumatology, University Hospital Frankfurt; M. Buslau, MD, Center for Rheumatology (Rehabilitation); K. Ahmadi-Simab, MD, Clinic for Internal Medicine, Klinikum Stephansplatz; A. Himsel, MD, Department of Rheumatology, GRP-Hospital Ruesselheim; A. Juche, MD, Department of Rheumatology, Immanuel Hospital; I. Koetter, MD, Department of Rheumatology, Asklepios Clinic Altona; A. Kuhn, MD, Division of Immunogenetics, German Cancer Research Center; M. Sticherling, MD, Department of Dermatology, University Hospital Erlangen; M. Hellmich, MD, Institute of Medical Statistics, Informatics and Epidemiology, University of Cologne; K. Kuhr, MD, Institute of Medical Statistics, Informatics and Epidemiology, University of Cologne; T. Krieg, MD, Department of Dermatology, University Hospital of Cologne; J. Ehrchen, MD, Department of Dermatology and Venereology, University Hospital Muenster; C. Sunderkoetter, MD, Department of Dermatology and Venereology, University Hospital Muenster; N. Hunzelmann, MD, Department of Dermatology, University Hospital of Cologne. Address correspondence to Dr. P. Moinzadeh, Department of Dermatology and Venereology, University of Cologne, Kerpener Str. 62, 50937 Cologne, Germany. E-mail: pia.moinzadeh@uk-koeln.de. Accepted for publication August 28, 2015.
Manfred Weber
From the Department of Dermatology, University Hospital of Cologne; Department of Internal Medicine, Hospital of Cologne Merheim; Institute of Medical Statistics, Informatics and Epidemiology, University of Cologne, Cologne; Department of Rheumatology, University Medical Center Schleswig-Holstein, Lübeck; Department of Rheumatology and Clinical Immunology, and Department of Dermatology, University of Berlin, Charité, Berlin; Department of Rheumatology, Immanuel Hospital, Berlin-Buch; Department of Dermatology, and Department of Rheumatology, University Hospital Tübingen, Tübingen; Department of Internal Medicine, Division of Rheumatology, Heidelberg University Hospital; Division of Immunogenetics, German Cancer Research Center, Heidelberg; Department of Rheumatology and Clinical Immunology, University Medical Center, Freiburg; Department of Rheumatology and Clinical Immunology, University of Giessen, Kerckhoff Clinic, Bad Nauheim; Department of Dermatology, HELIOS St. Elisabeth Clinic, Oberhausen; Department of Dermatology, St. Joseph Hospital, Ruhr- University of Bochum, Bochum; Department of Dermatology, University Hospital Carl Gustav Carus, Dresden; Department of Rheumatology, Johanniter-Hospital, Treuenbrietzen; Department of Dermatology, Ulm University Hospital, Ulm; Department of Dermatology, University Hospital Regensburg, Regensburg; Department of Rheumatology, Clinic of Rheumatology of Aachen, Aachen; Department of Dermatology, University Hospital Leipzig, Leipzig; Department of Rheumatology, and Department of Dermatology, University Hospital Erlangen, Erlangen; Department of Dermatology, TUM University Hospital; Department of Dermatology, Ludwig Maximilian University, Munich; Department of Rheumatology and Nephrology, University Hospital Duesseldorf, Duesseldorf; Department of Dermatology, University Hospital Göttingen, Göttingen; Department of Dermatology, University Medical Center, Johannes Gutenberg University, Mainz; Clinic for Dermatology, Hamburg Alstertal; Department of Dermatology, Helios Clinic, Wuppertal; Center for Rheumatology Bad Doberan, Bad Doberan; Center for Rheumatology Acura, Baden-Baden; Department of Dermatology, University Hospital of Würzburg, Würzburg; Department of Rheumatology, University Hospital Frankfurt, Frankfurt; Center for Rheumatology (Rehabilitation), Rheinfelden; Clinic for Internal Medicine, Klinikum Stephansplatz; Department of Rheumatology, Asklepios Clinic Altona, Hamburg; Department of Rheumatology, GRP-Hospital Ruesselheim, Darmstadt; Department of Dermatology and Venereology, University Hospital Muenster, Muenster, Germany; Department of Dermatology, Medical University of Graz, Graz, Austria. Supported by a grant of the German Federal Ministry of Education and Research (BMBF; 01GM0310 NH, TK; 01GM0631 CS) and the Edith Busch Foundation. The work of Pia Moinzadeh was supported by “Koeln Fortune” (155/2014) and “Deutsche Stiftung Sklerodermie” (3649/0096/31) grants. P. Moinzadeh, MD, Department of Dermatology, University Hospital of Cologne; G. Riemekasten, MD, Department of Rheumatology, University Medical Center Schleswig-Holstein; E. Siegert, Department of Rheumatology and Clinical Immunology, University of Berlin, Charité; G. Fierlbeck, MD, Department of Dermatology, University Hospital Tübingen; J. Henes, MD, Department of Rheumatology, University Hospital Tübingen; N. Blank, MD, Department of Internal Medicine, Division of Rheumatology, Heidelberg University Hospital; I. Melchers, MD, Department of Rheumatology and Clinical Immunology, University Medical Center; U. Mueller-Ladner, MD, Department of Rheumatology and Clinical Immunology, University of Giessen, Kerckhoff Clinic; M. Frerix, MD, Department of Rheumatology and Clinical Immunology, University of Giessen, Kerckhoff Clinic; A. Kreuter, MD, Department of Dermatology, HELIOS St. Elisabeth Clinic; C. Tigges, MD, Department of Dermatology, HELIOS St. Elisabeth Clinic; N. Lahner, MD, Department of Dermatology, St. Joseph Hospital, Ruhr-University of Bochum; L. Susok, MD, Department of Dermatology, St. Joseph Hospital, Ruhr-University of Bochum; C. Guenther, MD, Department of Dermatology, University Hospital Carl Gustav Carus; G. Zeidler, MD, Department of Rheumatology, Johanniter-Hospital; C. Pfeiffer, MD, Department of Dermatology, Ulm University Hospital; M. Worm, MD, Department of Dermatology, University of Berlin, Charité; S. Karrer, MD, Department of Dermatology, University Hospital Regensburg; E. Aberer, MD, Department of Dermatology, Medical University of Graz; A. Bretterklieber, MD, Department of Dermatology, Medical University of Graz; E. Genth, MD, Department of Rheumatology, Clinic of Rheumatology of Aachen; J.C. Simon, MD, Department of Dermatology, University Hospital Leipzig; J.H. Distler, MD, Department of Rheumatology, University Hospital Erlangen; R. Hein, MD, Department of Dermatology, TUM University Hospital; M. Schneider, MD, Department of Rheumatology and Nephrology, University Hospital Duesseldorf; C.S. Seitz, MD, Department of Dermatology, University Hospital Göttingen; C. Herink, MD, Department of Dermatology, University Hospital Göttingen; K. Steinbrink, MD, Department of Dermatology, University Medical Center, Johannes Gutenberg University; M. Sárdy, MD, Department of Dermatology, Ludwig Maximilian University; R. Varga, MD, Department of Dermatology, Ludwig Maximilian University; H. Mensing, MD, Clinic for Dermatology; C. Mensing, MD, Clinic for Dermatology; P. Lehmann, MD, Department of Dermatology, Helios Clinic; G. Neeck, MD, Center for Rheumatology Bad Doberan; C. Fiehn, MD, Center for Rheumatology Acura; M. Weber, MD, Department of Internal Medicine, Hospital of Cologne Merheim; M. Goebeler, MD, Department of Dermatology, University Hospital of Würzburg; H. Burkhardt, MD, Department of Rheumatology, University Hospital Frankfurt; M. Buslau, MD, Center for Rheumatology (Rehabilitation); K. Ahmadi-Simab, MD, Clinic for Internal Medicine, Klinikum Stephansplatz; A. Himsel, MD, Department of Rheumatology, GRP-Hospital Ruesselheim; A. Juche, MD, Department of Rheumatology, Immanuel Hospital; I. Koetter, MD, Department of Rheumatology, Asklepios Clinic Altona; A. Kuhn, MD, Division of Immunogenetics, German Cancer Research Center; M. Sticherling, MD, Department of Dermatology, University Hospital Erlangen; M. Hellmich, MD, Institute of Medical Statistics, Informatics and Epidemiology, University of Cologne; K. Kuhr, MD, Institute of Medical Statistics, Informatics and Epidemiology, University of Cologne; T. Krieg, MD, Department of Dermatology, University Hospital of Cologne; J. Ehrchen, MD, Department of Dermatology and Venereology, University Hospital Muenster; C. Sunderkoetter, MD, Department of Dermatology and Venereology, University Hospital Muenster; N. Hunzelmann, MD, Department of Dermatology, University Hospital of Cologne. Address correspondence to Dr. P. Moinzadeh, Department of Dermatology and Venereology, University of Cologne, Kerpener Str. 62, 50937 Cologne, Germany. E-mail: pia.moinzadeh@uk-koeln.de. Accepted for publication August 28, 2015.
Matthias Goebeler
From the Department of Dermatology, University Hospital of Cologne; Department of Internal Medicine, Hospital of Cologne Merheim; Institute of Medical Statistics, Informatics and Epidemiology, University of Cologne, Cologne; Department of Rheumatology, University Medical Center Schleswig-Holstein, Lübeck; Department of Rheumatology and Clinical Immunology, and Department of Dermatology, University of Berlin, Charité, Berlin; Department of Rheumatology, Immanuel Hospital, Berlin-Buch; Department of Dermatology, and Department of Rheumatology, University Hospital Tübingen, Tübingen; Department of Internal Medicine, Division of Rheumatology, Heidelberg University Hospital; Division of Immunogenetics, German Cancer Research Center, Heidelberg; Department of Rheumatology and Clinical Immunology, University Medical Center, Freiburg; Department of Rheumatology and Clinical Immunology, University of Giessen, Kerckhoff Clinic, Bad Nauheim; Department of Dermatology, HELIOS St. Elisabeth Clinic, Oberhausen; Department of Dermatology, St. Joseph Hospital, Ruhr- University of Bochum, Bochum; Department of Dermatology, University Hospital Carl Gustav Carus, Dresden; Department of Rheumatology, Johanniter-Hospital, Treuenbrietzen; Department of Dermatology, Ulm University Hospital, Ulm; Department of Dermatology, University Hospital Regensburg, Regensburg; Department of Rheumatology, Clinic of Rheumatology of Aachen, Aachen; Department of Dermatology, University Hospital Leipzig, Leipzig; Department of Rheumatology, and Department of Dermatology, University Hospital Erlangen, Erlangen; Department of Dermatology, TUM University Hospital; Department of Dermatology, Ludwig Maximilian University, Munich; Department of Rheumatology and Nephrology, University Hospital Duesseldorf, Duesseldorf; Department of Dermatology, University Hospital Göttingen, Göttingen; Department of Dermatology, University Medical Center, Johannes Gutenberg University, Mainz; Clinic for Dermatology, Hamburg Alstertal; Department of Dermatology, Helios Clinic, Wuppertal; Center for Rheumatology Bad Doberan, Bad Doberan; Center for Rheumatology Acura, Baden-Baden; Department of Dermatology, University Hospital of Würzburg, Würzburg; Department of Rheumatology, University Hospital Frankfurt, Frankfurt; Center for Rheumatology (Rehabilitation), Rheinfelden; Clinic for Internal Medicine, Klinikum Stephansplatz; Department of Rheumatology, Asklepios Clinic Altona, Hamburg; Department of Rheumatology, GRP-Hospital Ruesselheim, Darmstadt; Department of Dermatology and Venereology, University Hospital Muenster, Muenster, Germany; Department of Dermatology, Medical University of Graz, Graz, Austria. Supported by a grant of the German Federal Ministry of Education and Research (BMBF; 01GM0310 NH, TK; 01GM0631 CS) and the Edith Busch Foundation. The work of Pia Moinzadeh was supported by “Koeln Fortune” (155/2014) and “Deutsche Stiftung Sklerodermie” (3649/0096/31) grants. P. Moinzadeh, MD, Department of Dermatology, University Hospital of Cologne; G. Riemekasten, MD, Department of Rheumatology, University Medical Center Schleswig-Holstein; E. Siegert, Department of Rheumatology and Clinical Immunology, University of Berlin, Charité; G. Fierlbeck, MD, Department of Dermatology, University Hospital Tübingen; J. Henes, MD, Department of Rheumatology, University Hospital Tübingen; N. Blank, MD, Department of Internal Medicine, Division of Rheumatology, Heidelberg University Hospital; I. Melchers, MD, Department of Rheumatology and Clinical Immunology, University Medical Center; U. Mueller-Ladner, MD, Department of Rheumatology and Clinical Immunology, University of Giessen, Kerckhoff Clinic; M. Frerix, MD, Department of Rheumatology and Clinical Immunology, University of Giessen, Kerckhoff Clinic; A. Kreuter, MD, Department of Dermatology, HELIOS St. Elisabeth Clinic; C. Tigges, MD, Department of Dermatology, HELIOS St. Elisabeth Clinic; N. Lahner, MD, Department of Dermatology, St. Joseph Hospital, Ruhr-University of Bochum; L. Susok, MD, Department of Dermatology, St. Joseph Hospital, Ruhr-University of Bochum; C. Guenther, MD, Department of Dermatology, University Hospital Carl Gustav Carus; G. Zeidler, MD, Department of Rheumatology, Johanniter-Hospital; C. Pfeiffer, MD, Department of Dermatology, Ulm University Hospital; M. Worm, MD, Department of Dermatology, University of Berlin, Charité; S. Karrer, MD, Department of Dermatology, University Hospital Regensburg; E. Aberer, MD, Department of Dermatology, Medical University of Graz; A. Bretterklieber, MD, Department of Dermatology, Medical University of Graz; E. Genth, MD, Department of Rheumatology, Clinic of Rheumatology of Aachen; J.C. Simon, MD, Department of Dermatology, University Hospital Leipzig; J.H. Distler, MD, Department of Rheumatology, University Hospital Erlangen; R. Hein, MD, Department of Dermatology, TUM University Hospital; M. Schneider, MD, Department of Rheumatology and Nephrology, University Hospital Duesseldorf; C.S. Seitz, MD, Department of Dermatology, University Hospital Göttingen; C. Herink, MD, Department of Dermatology, University Hospital Göttingen; K. Steinbrink, MD, Department of Dermatology, University Medical Center, Johannes Gutenberg University; M. Sárdy, MD, Department of Dermatology, Ludwig Maximilian University; R. Varga, MD, Department of Dermatology, Ludwig Maximilian University; H. Mensing, MD, Clinic for Dermatology; C. Mensing, MD, Clinic for Dermatology; P. Lehmann, MD, Department of Dermatology, Helios Clinic; G. Neeck, MD, Center for Rheumatology Bad Doberan; C. Fiehn, MD, Center for Rheumatology Acura; M. Weber, MD, Department of Internal Medicine, Hospital of Cologne Merheim; M. Goebeler, MD, Department of Dermatology, University Hospital of Würzburg; H. Burkhardt, MD, Department of Rheumatology, University Hospital Frankfurt; M. Buslau, MD, Center for Rheumatology (Rehabilitation); K. Ahmadi-Simab, MD, Clinic for Internal Medicine, Klinikum Stephansplatz; A. Himsel, MD, Department of Rheumatology, GRP-Hospital Ruesselheim; A. Juche, MD, Department of Rheumatology, Immanuel Hospital; I. Koetter, MD, Department of Rheumatology, Asklepios Clinic Altona; A. Kuhn, MD, Division of Immunogenetics, German Cancer Research Center; M. Sticherling, MD, Department of Dermatology, University Hospital Erlangen; M. Hellmich, MD, Institute of Medical Statistics, Informatics and Epidemiology, University of Cologne; K. Kuhr, MD, Institute of Medical Statistics, Informatics and Epidemiology, University of Cologne; T. Krieg, MD, Department of Dermatology, University Hospital of Cologne; J. Ehrchen, MD, Department of Dermatology and Venereology, University Hospital Muenster; C. Sunderkoetter, MD, Department of Dermatology and Venereology, University Hospital Muenster; N. Hunzelmann, MD, Department of Dermatology, University Hospital of Cologne. Address correspondence to Dr. P. Moinzadeh, Department of Dermatology and Venereology, University of Cologne, Kerpener Str. 62, 50937 Cologne, Germany. E-mail: pia.moinzadeh@uk-koeln.de. Accepted for publication August 28, 2015.
Harald Burkhardt
From the Department of Dermatology, University Hospital of Cologne; Department of Internal Medicine, Hospital of Cologne Merheim; Institute of Medical Statistics, Informatics and Epidemiology, University of Cologne, Cologne; Department of Rheumatology, University Medical Center Schleswig-Holstein, Lübeck; Department of Rheumatology and Clinical Immunology, and Department of Dermatology, University of Berlin, Charité, Berlin; Department of Rheumatology, Immanuel Hospital, Berlin-Buch; Department of Dermatology, and Department of Rheumatology, University Hospital Tübingen, Tübingen; Department of Internal Medicine, Division of Rheumatology, Heidelberg University Hospital; Division of Immunogenetics, German Cancer Research Center, Heidelberg; Department of Rheumatology and Clinical Immunology, University Medical Center, Freiburg; Department of Rheumatology and Clinical Immunology, University of Giessen, Kerckhoff Clinic, Bad Nauheim; Department of Dermatology, HELIOS St. Elisabeth Clinic, Oberhausen; Department of Dermatology, St. Joseph Hospital, Ruhr- University of Bochum, Bochum; Department of Dermatology, University Hospital Carl Gustav Carus, Dresden; Department of Rheumatology, Johanniter-Hospital, Treuenbrietzen; Department of Dermatology, Ulm University Hospital, Ulm; Department of Dermatology, University Hospital Regensburg, Regensburg; Department of Rheumatology, Clinic of Rheumatology of Aachen, Aachen; Department of Dermatology, University Hospital Leipzig, Leipzig; Department of Rheumatology, and Department of Dermatology, University Hospital Erlangen, Erlangen; Department of Dermatology, TUM University Hospital; Department of Dermatology, Ludwig Maximilian University, Munich; Department of Rheumatology and Nephrology, University Hospital Duesseldorf, Duesseldorf; Department of Dermatology, University Hospital Göttingen, Göttingen; Department of Dermatology, University Medical Center, Johannes Gutenberg University, Mainz; Clinic for Dermatology, Hamburg Alstertal; Department of Dermatology, Helios Clinic, Wuppertal; Center for Rheumatology Bad Doberan, Bad Doberan; Center for Rheumatology Acura, Baden-Baden; Department of Dermatology, University Hospital of Würzburg, Würzburg; Department of Rheumatology, University Hospital Frankfurt, Frankfurt; Center for Rheumatology (Rehabilitation), Rheinfelden; Clinic for Internal Medicine, Klinikum Stephansplatz; Department of Rheumatology, Asklepios Clinic Altona, Hamburg; Department of Rheumatology, GRP-Hospital Ruesselheim, Darmstadt; Department of Dermatology and Venereology, University Hospital Muenster, Muenster, Germany; Department of Dermatology, Medical University of Graz, Graz, Austria. Supported by a grant of the German Federal Ministry of Education and Research (BMBF; 01GM0310 NH, TK; 01GM0631 CS) and the Edith Busch Foundation. The work of Pia Moinzadeh was supported by “Koeln Fortune” (155/2014) and “Deutsche Stiftung Sklerodermie” (3649/0096/31) grants. P. Moinzadeh, MD, Department of Dermatology, University Hospital of Cologne; G. Riemekasten, MD, Department of Rheumatology, University Medical Center Schleswig-Holstein; E. Siegert, Department of Rheumatology and Clinical Immunology, University of Berlin, Charité; G. Fierlbeck, MD, Department of Dermatology, University Hospital Tübingen; J. Henes, MD, Department of Rheumatology, University Hospital Tübingen; N. Blank, MD, Department of Internal Medicine, Division of Rheumatology, Heidelberg University Hospital; I. Melchers, MD, Department of Rheumatology and Clinical Immunology, University Medical Center; U. Mueller-Ladner, MD, Department of Rheumatology and Clinical Immunology, University of Giessen, Kerckhoff Clinic; M. Frerix, MD, Department of Rheumatology and Clinical Immunology, University of Giessen, Kerckhoff Clinic; A. Kreuter, MD, Department of Dermatology, HELIOS St. Elisabeth Clinic; C. Tigges, MD, Department of Dermatology, HELIOS St. Elisabeth Clinic; N. Lahner, MD, Department of Dermatology, St. Joseph Hospital, Ruhr-University of Bochum; L. Susok, MD, Department of Dermatology, St. Joseph Hospital, Ruhr-University of Bochum; C. Guenther, MD, Department of Dermatology, University Hospital Carl Gustav Carus; G. Zeidler, MD, Department of Rheumatology, Johanniter-Hospital; C. Pfeiffer, MD, Department of Dermatology, Ulm University Hospital; M. Worm, MD, Department of Dermatology, University of Berlin, Charité; S. Karrer, MD, Department of Dermatology, University Hospital Regensburg; E. Aberer, MD, Department of Dermatology, Medical University of Graz; A. Bretterklieber, MD, Department of Dermatology, Medical University of Graz; E. Genth, MD, Department of Rheumatology, Clinic of Rheumatology of Aachen; J.C. Simon, MD, Department of Dermatology, University Hospital Leipzig; J.H. Distler, MD, Department of Rheumatology, University Hospital Erlangen; R. Hein, MD, Department of Dermatology, TUM University Hospital; M. Schneider, MD, Department of Rheumatology and Nephrology, University Hospital Duesseldorf; C.S. Seitz, MD, Department of Dermatology, University Hospital Göttingen; C. Herink, MD, Department of Dermatology, University Hospital Göttingen; K. Steinbrink, MD, Department of Dermatology, University Medical Center, Johannes Gutenberg University; M. Sárdy, MD, Department of Dermatology, Ludwig Maximilian University; R. Varga, MD, Department of Dermatology, Ludwig Maximilian University; H. Mensing, MD, Clinic for Dermatology; C. Mensing, MD, Clinic for Dermatology; P. Lehmann, MD, Department of Dermatology, Helios Clinic; G. Neeck, MD, Center for Rheumatology Bad Doberan; C. Fiehn, MD, Center for Rheumatology Acura; M. Weber, MD, Department of Internal Medicine, Hospital of Cologne Merheim; M. Goebeler, MD, Department of Dermatology, University Hospital of Würzburg; H. Burkhardt, MD, Department of Rheumatology, University Hospital Frankfurt; M. Buslau, MD, Center for Rheumatology (Rehabilitation); K. Ahmadi-Simab, MD, Clinic for Internal Medicine, Klinikum Stephansplatz; A. Himsel, MD, Department of Rheumatology, GRP-Hospital Ruesselheim; A. Juche, MD, Department of Rheumatology, Immanuel Hospital; I. Koetter, MD, Department of Rheumatology, Asklepios Clinic Altona; A. Kuhn, MD, Division of Immunogenetics, German Cancer Research Center; M. Sticherling, MD, Department of Dermatology, University Hospital Erlangen; M. Hellmich, MD, Institute of Medical Statistics, Informatics and Epidemiology, University of Cologne; K. Kuhr, MD, Institute of Medical Statistics, Informatics and Epidemiology, University of Cologne; T. Krieg, MD, Department of Dermatology, University Hospital of Cologne; J. Ehrchen, MD, Department of Dermatology and Venereology, University Hospital Muenster; C. Sunderkoetter, MD, Department of Dermatology and Venereology, University Hospital Muenster; N. Hunzelmann, MD, Department of Dermatology, University Hospital of Cologne. Address correspondence to Dr. P. Moinzadeh, Department of Dermatology and Venereology, University of Cologne, Kerpener Str. 62, 50937 Cologne, Germany. E-mail: pia.moinzadeh@uk-koeln.de. Accepted for publication August 28, 2015.
Michael Buslau
From the Department of Dermatology, University Hospital of Cologne; Department of Internal Medicine, Hospital of Cologne Merheim; Institute of Medical Statistics, Informatics and Epidemiology, University of Cologne, Cologne; Department of Rheumatology, University Medical Center Schleswig-Holstein, Lübeck; Department of Rheumatology and Clinical Immunology, and Department of Dermatology, University of Berlin, Charité, Berlin; Department of Rheumatology, Immanuel Hospital, Berlin-Buch; Department of Dermatology, and Department of Rheumatology, University Hospital Tübingen, Tübingen; Department of Internal Medicine, Division of Rheumatology, Heidelberg University Hospital; Division of Immunogenetics, German Cancer Research Center, Heidelberg; Department of Rheumatology and Clinical Immunology, University Medical Center, Freiburg; Department of Rheumatology and Clinical Immunology, University of Giessen, Kerckhoff Clinic, Bad Nauheim; Department of Dermatology, HELIOS St. Elisabeth Clinic, Oberhausen; Department of Dermatology, St. Joseph Hospital, Ruhr- University of Bochum, Bochum; Department of Dermatology, University Hospital Carl Gustav Carus, Dresden; Department of Rheumatology, Johanniter-Hospital, Treuenbrietzen; Department of Dermatology, Ulm University Hospital, Ulm; Department of Dermatology, University Hospital Regensburg, Regensburg; Department of Rheumatology, Clinic of Rheumatology of Aachen, Aachen; Department of Dermatology, University Hospital Leipzig, Leipzig; Department of Rheumatology, and Department of Dermatology, University Hospital Erlangen, Erlangen; Department of Dermatology, TUM University Hospital; Department of Dermatology, Ludwig Maximilian University, Munich; Department of Rheumatology and Nephrology, University Hospital Duesseldorf, Duesseldorf; Department of Dermatology, University Hospital Göttingen, Göttingen; Department of Dermatology, University Medical Center, Johannes Gutenberg University, Mainz; Clinic for Dermatology, Hamburg Alstertal; Department of Dermatology, Helios Clinic, Wuppertal; Center for Rheumatology Bad Doberan, Bad Doberan; Center for Rheumatology Acura, Baden-Baden; Department of Dermatology, University Hospital of Würzburg, Würzburg; Department of Rheumatology, University Hospital Frankfurt, Frankfurt; Center for Rheumatology (Rehabilitation), Rheinfelden; Clinic for Internal Medicine, Klinikum Stephansplatz; Department of Rheumatology, Asklepios Clinic Altona, Hamburg; Department of Rheumatology, GRP-Hospital Ruesselheim, Darmstadt; Department of Dermatology and Venereology, University Hospital Muenster, Muenster, Germany; Department of Dermatology, Medical University of Graz, Graz, Austria. Supported by a grant of the German Federal Ministry of Education and Research (BMBF; 01GM0310 NH, TK; 01GM0631 CS) and the Edith Busch Foundation. The work of Pia Moinzadeh was supported by “Koeln Fortune” (155/2014) and “Deutsche Stiftung Sklerodermie” (3649/0096/31) grants. P. Moinzadeh, MD, Department of Dermatology, University Hospital of Cologne; G. Riemekasten, MD, Department of Rheumatology, University Medical Center Schleswig-Holstein; E. Siegert, Department of Rheumatology and Clinical Immunology, University of Berlin, Charité; G. Fierlbeck, MD, Department of Dermatology, University Hospital Tübingen; J. Henes, MD, Department of Rheumatology, University Hospital Tübingen; N. Blank, MD, Department of Internal Medicine, Division of Rheumatology, Heidelberg University Hospital; I. Melchers, MD, Department of Rheumatology and Clinical Immunology, University Medical Center; U. Mueller-Ladner, MD, Department of Rheumatology and Clinical Immunology, University of Giessen, Kerckhoff Clinic; M. Frerix, MD, Department of Rheumatology and Clinical Immunology, University of Giessen, Kerckhoff Clinic; A. Kreuter, MD, Department of Dermatology, HELIOS St. Elisabeth Clinic; C. Tigges, MD, Department of Dermatology, HELIOS St. Elisabeth Clinic; N. Lahner, MD, Department of Dermatology, St. Joseph Hospital, Ruhr-University of Bochum; L. Susok, MD, Department of Dermatology, St. Joseph Hospital, Ruhr-University of Bochum; C. Guenther, MD, Department of Dermatology, University Hospital Carl Gustav Carus; G. Zeidler, MD, Department of Rheumatology, Johanniter-Hospital; C. Pfeiffer, MD, Department of Dermatology, Ulm University Hospital; M. Worm, MD, Department of Dermatology, University of Berlin, Charité; S. Karrer, MD, Department of Dermatology, University Hospital Regensburg; E. Aberer, MD, Department of Dermatology, Medical University of Graz; A. Bretterklieber, MD, Department of Dermatology, Medical University of Graz; E. Genth, MD, Department of Rheumatology, Clinic of Rheumatology of Aachen; J.C. Simon, MD, Department of Dermatology, University Hospital Leipzig; J.H. Distler, MD, Department of Rheumatology, University Hospital Erlangen; R. Hein, MD, Department of Dermatology, TUM University Hospital; M. Schneider, MD, Department of Rheumatology and Nephrology, University Hospital Duesseldorf; C.S. Seitz, MD, Department of Dermatology, University Hospital Göttingen; C. Herink, MD, Department of Dermatology, University Hospital Göttingen; K. Steinbrink, MD, Department of Dermatology, University Medical Center, Johannes Gutenberg University; M. Sárdy, MD, Department of Dermatology, Ludwig Maximilian University; R. Varga, MD, Department of Dermatology, Ludwig Maximilian University; H. Mensing, MD, Clinic for Dermatology; C. Mensing, MD, Clinic for Dermatology; P. Lehmann, MD, Department of Dermatology, Helios Clinic; G. Neeck, MD, Center for Rheumatology Bad Doberan; C. Fiehn, MD, Center for Rheumatology Acura; M. Weber, MD, Department of Internal Medicine, Hospital of Cologne Merheim; M. Goebeler, MD, Department of Dermatology, University Hospital of Würzburg; H. Burkhardt, MD, Department of Rheumatology, University Hospital Frankfurt; M. Buslau, MD, Center for Rheumatology (Rehabilitation); K. Ahmadi-Simab, MD, Clinic for Internal Medicine, Klinikum Stephansplatz; A. Himsel, MD, Department of Rheumatology, GRP-Hospital Ruesselheim; A. Juche, MD, Department of Rheumatology, Immanuel Hospital; I. Koetter, MD, Department of Rheumatology, Asklepios Clinic Altona; A. Kuhn, MD, Division of Immunogenetics, German Cancer Research Center; M. Sticherling, MD, Department of Dermatology, University Hospital Erlangen; M. Hellmich, MD, Institute of Medical Statistics, Informatics and Epidemiology, University of Cologne; K. Kuhr, MD, Institute of Medical Statistics, Informatics and Epidemiology, University of Cologne; T. Krieg, MD, Department of Dermatology, University Hospital of Cologne; J. Ehrchen, MD, Department of Dermatology and Venereology, University Hospital Muenster; C. Sunderkoetter, MD, Department of Dermatology and Venereology, University Hospital Muenster; N. Hunzelmann, MD, Department of Dermatology, University Hospital of Cologne. Address correspondence to Dr. P. Moinzadeh, Department of Dermatology and Venereology, University of Cologne, Kerpener Str. 62, 50937 Cologne, Germany. E-mail: pia.moinzadeh@uk-koeln.de. Accepted for publication August 28, 2015.
Keihan Ahmadi-Simab
From the Department of Dermatology, University Hospital of Cologne; Department of Internal Medicine, Hospital of Cologne Merheim; Institute of Medical Statistics, Informatics and Epidemiology, University of Cologne, Cologne; Department of Rheumatology, University Medical Center Schleswig-Holstein, Lübeck; Department of Rheumatology and Clinical Immunology, and Department of Dermatology, University of Berlin, Charité, Berlin; Department of Rheumatology, Immanuel Hospital, Berlin-Buch; Department of Dermatology, and Department of Rheumatology, University Hospital Tübingen, Tübingen; Department of Internal Medicine, Division of Rheumatology, Heidelberg University Hospital; Division of Immunogenetics, German Cancer Research Center, Heidelberg; Department of Rheumatology and Clinical Immunology, University Medical Center, Freiburg; Department of Rheumatology and Clinical Immunology, University of Giessen, Kerckhoff Clinic, Bad Nauheim; Department of Dermatology, HELIOS St. Elisabeth Clinic, Oberhausen; Department of Dermatology, St. Joseph Hospital, Ruhr- University of Bochum, Bochum; Department of Dermatology, University Hospital Carl Gustav Carus, Dresden; Department of Rheumatology, Johanniter-Hospital, Treuenbrietzen; Department of Dermatology, Ulm University Hospital, Ulm; Department of Dermatology, University Hospital Regensburg, Regensburg; Department of Rheumatology, Clinic of Rheumatology of Aachen, Aachen; Department of Dermatology, University Hospital Leipzig, Leipzig; Department of Rheumatology, and Department of Dermatology, University Hospital Erlangen, Erlangen; Department of Dermatology, TUM University Hospital; Department of Dermatology, Ludwig Maximilian University, Munich; Department of Rheumatology and Nephrology, University Hospital Duesseldorf, Duesseldorf; Department of Dermatology, University Hospital Göttingen, Göttingen; Department of Dermatology, University Medical Center, Johannes Gutenberg University, Mainz; Clinic for Dermatology, Hamburg Alstertal; Department of Dermatology, Helios Clinic, Wuppertal; Center for Rheumatology Bad Doberan, Bad Doberan; Center for Rheumatology Acura, Baden-Baden; Department of Dermatology, University Hospital of Würzburg, Würzburg; Department of Rheumatology, University Hospital Frankfurt, Frankfurt; Center for Rheumatology (Rehabilitation), Rheinfelden; Clinic for Internal Medicine, Klinikum Stephansplatz; Department of Rheumatology, Asklepios Clinic Altona, Hamburg; Department of Rheumatology, GRP-Hospital Ruesselheim, Darmstadt; Department of Dermatology and Venereology, University Hospital Muenster, Muenster, Germany; Department of Dermatology, Medical University of Graz, Graz, Austria. Supported by a grant of the German Federal Ministry of Education and Research (BMBF; 01GM0310 NH, TK; 01GM0631 CS) and the Edith Busch Foundation. The work of Pia Moinzadeh was supported by “Koeln Fortune” (155/2014) and “Deutsche Stiftung Sklerodermie” (3649/0096/31) grants. P. Moinzadeh, MD, Department of Dermatology, University Hospital of Cologne; G. Riemekasten, MD, Department of Rheumatology, University Medical Center Schleswig-Holstein; E. Siegert, Department of Rheumatology and Clinical Immunology, University of Berlin, Charité; G. Fierlbeck, MD, Department of Dermatology, University Hospital Tübingen; J. Henes, MD, Department of Rheumatology, University Hospital Tübingen; N. Blank, MD, Department of Internal Medicine, Division of Rheumatology, Heidelberg University Hospital; I. Melchers, MD, Department of Rheumatology and Clinical Immunology, University Medical Center; U. Mueller-Ladner, MD, Department of Rheumatology and Clinical Immunology, University of Giessen, Kerckhoff Clinic; M. Frerix, MD, Department of Rheumatology and Clinical Immunology, University of Giessen, Kerckhoff Clinic; A. Kreuter, MD, Department of Dermatology, HELIOS St. Elisabeth Clinic; C. Tigges, MD, Department of Dermatology, HELIOS St. Elisabeth Clinic; N. Lahner, MD, Department of Dermatology, St. Joseph Hospital, Ruhr-University of Bochum; L. Susok, MD, Department of Dermatology, St. Joseph Hospital, Ruhr-University of Bochum; C. Guenther, MD, Department of Dermatology, University Hospital Carl Gustav Carus; G. Zeidler, MD, Department of Rheumatology, Johanniter-Hospital; C. Pfeiffer, MD, Department of Dermatology, Ulm University Hospital; M. Worm, MD, Department of Dermatology, University of Berlin, Charité; S. Karrer, MD, Department of Dermatology, University Hospital Regensburg; E. Aberer, MD, Department of Dermatology, Medical University of Graz; A. Bretterklieber, MD, Department of Dermatology, Medical University of Graz; E. Genth, MD, Department of Rheumatology, Clinic of Rheumatology of Aachen; J.C. Simon, MD, Department of Dermatology, University Hospital Leipzig; J.H. Distler, MD, Department of Rheumatology, University Hospital Erlangen; R. Hein, MD, Department of Dermatology, TUM University Hospital; M. Schneider, MD, Department of Rheumatology and Nephrology, University Hospital Duesseldorf; C.S. Seitz, MD, Department of Dermatology, University Hospital Göttingen; C. Herink, MD, Department of Dermatology, University Hospital Göttingen; K. Steinbrink, MD, Department of Dermatology, University Medical Center, Johannes Gutenberg University; M. Sárdy, MD, Department of Dermatology, Ludwig Maximilian University; R. Varga, MD, Department of Dermatology, Ludwig Maximilian University; H. Mensing, MD, Clinic for Dermatology; C. Mensing, MD, Clinic for Dermatology; P. Lehmann, MD, Department of Dermatology, Helios Clinic; G. Neeck, MD, Center for Rheumatology Bad Doberan; C. Fiehn, MD, Center for Rheumatology Acura; M. Weber, MD, Department of Internal Medicine, Hospital of Cologne Merheim; M. Goebeler, MD, Department of Dermatology, University Hospital of Würzburg; H. Burkhardt, MD, Department of Rheumatology, University Hospital Frankfurt; M. Buslau, MD, Center for Rheumatology (Rehabilitation); K. Ahmadi-Simab, MD, Clinic for Internal Medicine, Klinikum Stephansplatz; A. Himsel, MD, Department of Rheumatology, GRP-Hospital Ruesselheim; A. Juche, MD, Department of Rheumatology, Immanuel Hospital; I. Koetter, MD, Department of Rheumatology, Asklepios Clinic Altona; A. Kuhn, MD, Division of Immunogenetics, German Cancer Research Center; M. Sticherling, MD, Department of Dermatology, University Hospital Erlangen; M. Hellmich, MD, Institute of Medical Statistics, Informatics and Epidemiology, University of Cologne; K. Kuhr, MD, Institute of Medical Statistics, Informatics and Epidemiology, University of Cologne; T. Krieg, MD, Department of Dermatology, University Hospital of Cologne; J. Ehrchen, MD, Department of Dermatology and Venereology, University Hospital Muenster; C. Sunderkoetter, MD, Department of Dermatology and Venereology, University Hospital Muenster; N. Hunzelmann, MD, Department of Dermatology, University Hospital of Cologne. Address correspondence to Dr. P. Moinzadeh, Department of Dermatology and Venereology, University of Cologne, Kerpener Str. 62, 50937 Cologne, Germany. E-mail: pia.moinzadeh@uk-koeln.de. Accepted for publication August 28, 2015.
Andrea Himsel
From the Department of Dermatology, University Hospital of Cologne; Department of Internal Medicine, Hospital of Cologne Merheim; Institute of Medical Statistics, Informatics and Epidemiology, University of Cologne, Cologne; Department of Rheumatology, University Medical Center Schleswig-Holstein, Lübeck; Department of Rheumatology and Clinical Immunology, and Department of Dermatology, University of Berlin, Charité, Berlin; Department of Rheumatology, Immanuel Hospital, Berlin-Buch; Department of Dermatology, and Department of Rheumatology, University Hospital Tübingen, Tübingen; Department of Internal Medicine, Division of Rheumatology, Heidelberg University Hospital; Division of Immunogenetics, German Cancer Research Center, Heidelberg; Department of Rheumatology and Clinical Immunology, University Medical Center, Freiburg; Department of Rheumatology and Clinical Immunology, University of Giessen, Kerckhoff Clinic, Bad Nauheim; Department of Dermatology, HELIOS St. Elisabeth Clinic, Oberhausen; Department of Dermatology, St. Joseph Hospital, Ruhr- University of Bochum, Bochum; Department of Dermatology, University Hospital Carl Gustav Carus, Dresden; Department of Rheumatology, Johanniter-Hospital, Treuenbrietzen; Department of Dermatology, Ulm University Hospital, Ulm; Department of Dermatology, University Hospital Regensburg, Regensburg; Department of Rheumatology, Clinic of Rheumatology of Aachen, Aachen; Department of Dermatology, University Hospital Leipzig, Leipzig; Department of Rheumatology, and Department of Dermatology, University Hospital Erlangen, Erlangen; Department of Dermatology, TUM University Hospital; Department of Dermatology, Ludwig Maximilian University, Munich; Department of Rheumatology and Nephrology, University Hospital Duesseldorf, Duesseldorf; Department of Dermatology, University Hospital Göttingen, Göttingen; Department of Dermatology, University Medical Center, Johannes Gutenberg University, Mainz; Clinic for Dermatology, Hamburg Alstertal; Department of Dermatology, Helios Clinic, Wuppertal; Center for Rheumatology Bad Doberan, Bad Doberan; Center for Rheumatology Acura, Baden-Baden; Department of Dermatology, University Hospital of Würzburg, Würzburg; Department of Rheumatology, University Hospital Frankfurt, Frankfurt; Center for Rheumatology (Rehabilitation), Rheinfelden; Clinic for Internal Medicine, Klinikum Stephansplatz; Department of Rheumatology, Asklepios Clinic Altona, Hamburg; Department of Rheumatology, GRP-Hospital Ruesselheim, Darmstadt; Department of Dermatology and Venereology, University Hospital Muenster, Muenster, Germany; Department of Dermatology, Medical University of Graz, Graz, Austria. Supported by a grant of the German Federal Ministry of Education and Research (BMBF; 01GM0310 NH, TK; 01GM0631 CS) and the Edith Busch Foundation. The work of Pia Moinzadeh was supported by “Koeln Fortune” (155/2014) and “Deutsche Stiftung Sklerodermie” (3649/0096/31) grants. P. Moinzadeh, MD, Department of Dermatology, University Hospital of Cologne; G. Riemekasten, MD, Department of Rheumatology, University Medical Center Schleswig-Holstein; E. Siegert, Department of Rheumatology and Clinical Immunology, University of Berlin, Charité; G. Fierlbeck, MD, Department of Dermatology, University Hospital Tübingen; J. Henes, MD, Department of Rheumatology, University Hospital Tübingen; N. Blank, MD, Department of Internal Medicine, Division of Rheumatology, Heidelberg University Hospital; I. Melchers, MD, Department of Rheumatology and Clinical Immunology, University Medical Center; U. Mueller-Ladner, MD, Department of Rheumatology and Clinical Immunology, University of Giessen, Kerckhoff Clinic; M. Frerix, MD, Department of Rheumatology and Clinical Immunology, University of Giessen, Kerckhoff Clinic; A. Kreuter, MD, Department of Dermatology, HELIOS St. Elisabeth Clinic; C. Tigges, MD, Department of Dermatology, HELIOS St. Elisabeth Clinic; N. Lahner, MD, Department of Dermatology, St. Joseph Hospital, Ruhr-University of Bochum; L. Susok, MD, Department of Dermatology, St. Joseph Hospital, Ruhr-University of Bochum; C. Guenther, MD, Department of Dermatology, University Hospital Carl Gustav Carus; G. Zeidler, MD, Department of Rheumatology, Johanniter-Hospital; C. Pfeiffer, MD, Department of Dermatology, Ulm University Hospital; M. Worm, MD, Department of Dermatology, University of Berlin, Charité; S. Karrer, MD, Department of Dermatology, University Hospital Regensburg; E. Aberer, MD, Department of Dermatology, Medical University of Graz; A. Bretterklieber, MD, Department of Dermatology, Medical University of Graz; E. Genth, MD, Department of Rheumatology, Clinic of Rheumatology of Aachen; J.C. Simon, MD, Department of Dermatology, University Hospital Leipzig; J.H. Distler, MD, Department of Rheumatology, University Hospital Erlangen; R. Hein, MD, Department of Dermatology, TUM University Hospital; M. Schneider, MD, Department of Rheumatology and Nephrology, University Hospital Duesseldorf; C.S. Seitz, MD, Department of Dermatology, University Hospital Göttingen; C. Herink, MD, Department of Dermatology, University Hospital Göttingen; K. Steinbrink, MD, Department of Dermatology, University Medical Center, Johannes Gutenberg University; M. Sárdy, MD, Department of Dermatology, Ludwig Maximilian University; R. Varga, MD, Department of Dermatology, Ludwig Maximilian University; H. Mensing, MD, Clinic for Dermatology; C. Mensing, MD, Clinic for Dermatology; P. Lehmann, MD, Department of Dermatology, Helios Clinic; G. Neeck, MD, Center for Rheumatology Bad Doberan; C. Fiehn, MD, Center for Rheumatology Acura; M. Weber, MD, Department of Internal Medicine, Hospital of Cologne Merheim; M. Goebeler, MD, Department of Dermatology, University Hospital of Würzburg; H. Burkhardt, MD, Department of Rheumatology, University Hospital Frankfurt; M. Buslau, MD, Center for Rheumatology (Rehabilitation); K. Ahmadi-Simab, MD, Clinic for Internal Medicine, Klinikum Stephansplatz; A. Himsel, MD, Department of Rheumatology, GRP-Hospital Ruesselheim; A. Juche, MD, Department of Rheumatology, Immanuel Hospital; I. Koetter, MD, Department of Rheumatology, Asklepios Clinic Altona; A. Kuhn, MD, Division of Immunogenetics, German Cancer Research Center; M. Sticherling, MD, Department of Dermatology, University Hospital Erlangen; M. Hellmich, MD, Institute of Medical Statistics, Informatics and Epidemiology, University of Cologne; K. Kuhr, MD, Institute of Medical Statistics, Informatics and Epidemiology, University of Cologne; T. Krieg, MD, Department of Dermatology, University Hospital of Cologne; J. Ehrchen, MD, Department of Dermatology and Venereology, University Hospital Muenster; C. Sunderkoetter, MD, Department of Dermatology and Venereology, University Hospital Muenster; N. Hunzelmann, MD, Department of Dermatology, University Hospital of Cologne. Address correspondence to Dr. P. Moinzadeh, Department of Dermatology and Venereology, University of Cologne, Kerpener Str. 62, 50937 Cologne, Germany. E-mail: pia.moinzadeh@uk-koeln.de. Accepted for publication August 28, 2015.
Aaron Juche
From the Department of Dermatology, University Hospital of Cologne; Department of Internal Medicine, Hospital of Cologne Merheim; Institute of Medical Statistics, Informatics and Epidemiology, University of Cologne, Cologne; Department of Rheumatology, University Medical Center Schleswig-Holstein, Lübeck; Department of Rheumatology and Clinical Immunology, and Department of Dermatology, University of Berlin, Charité, Berlin; Department of Rheumatology, Immanuel Hospital, Berlin-Buch; Department of Dermatology, and Department of Rheumatology, University Hospital Tübingen, Tübingen; Department of Internal Medicine, Division of Rheumatology, Heidelberg University Hospital; Division of Immunogenetics, German Cancer Research Center, Heidelberg; Department of Rheumatology and Clinical Immunology, University Medical Center, Freiburg; Department of Rheumatology and Clinical Immunology, University of Giessen, Kerckhoff Clinic, Bad Nauheim; Department of Dermatology, HELIOS St. Elisabeth Clinic, Oberhausen; Department of Dermatology, St. Joseph Hospital, Ruhr- University of Bochum, Bochum; Department of Dermatology, University Hospital Carl Gustav Carus, Dresden; Department of Rheumatology, Johanniter-Hospital, Treuenbrietzen; Department of Dermatology, Ulm University Hospital, Ulm; Department of Dermatology, University Hospital Regensburg, Regensburg; Department of Rheumatology, Clinic of Rheumatology of Aachen, Aachen; Department of Dermatology, University Hospital Leipzig, Leipzig; Department of Rheumatology, and Department of Dermatology, University Hospital Erlangen, Erlangen; Department of Dermatology, TUM University Hospital; Department of Dermatology, Ludwig Maximilian University, Munich; Department of Rheumatology and Nephrology, University Hospital Duesseldorf, Duesseldorf; Department of Dermatology, University Hospital Göttingen, Göttingen; Department of Dermatology, University Medical Center, Johannes Gutenberg University, Mainz; Clinic for Dermatology, Hamburg Alstertal; Department of Dermatology, Helios Clinic, Wuppertal; Center for Rheumatology Bad Doberan, Bad Doberan; Center for Rheumatology Acura, Baden-Baden; Department of Dermatology, University Hospital of Würzburg, Würzburg; Department of Rheumatology, University Hospital Frankfurt, Frankfurt; Center for Rheumatology (Rehabilitation), Rheinfelden; Clinic for Internal Medicine, Klinikum Stephansplatz; Department of Rheumatology, Asklepios Clinic Altona, Hamburg; Department of Rheumatology, GRP-Hospital Ruesselheim, Darmstadt; Department of Dermatology and Venereology, University Hospital Muenster, Muenster, Germany; Department of Dermatology, Medical University of Graz, Graz, Austria. Supported by a grant of the German Federal Ministry of Education and Research (BMBF; 01GM0310 NH, TK; 01GM0631 CS) and the Edith Busch Foundation. The work of Pia Moinzadeh was supported by “Koeln Fortune” (155/2014) and “Deutsche Stiftung Sklerodermie” (3649/0096/31) grants. P. Moinzadeh, MD, Department of Dermatology, University Hospital of Cologne; G. Riemekasten, MD, Department of Rheumatology, University Medical Center Schleswig-Holstein; E. Siegert, Department of Rheumatology and Clinical Immunology, University of Berlin, Charité; G. Fierlbeck, MD, Department of Dermatology, University Hospital Tübingen; J. Henes, MD, Department of Rheumatology, University Hospital Tübingen; N. Blank, MD, Department of Internal Medicine, Division of Rheumatology, Heidelberg University Hospital; I. Melchers, MD, Department of Rheumatology and Clinical Immunology, University Medical Center; U. Mueller-Ladner, MD, Department of Rheumatology and Clinical Immunology, University of Giessen, Kerckhoff Clinic; M. Frerix, MD, Department of Rheumatology and Clinical Immunology, University of Giessen, Kerckhoff Clinic; A. Kreuter, MD, Department of Dermatology, HELIOS St. Elisabeth Clinic; C. Tigges, MD, Department of Dermatology, HELIOS St. Elisabeth Clinic; N. Lahner, MD, Department of Dermatology, St. Joseph Hospital, Ruhr-University of Bochum; L. Susok, MD, Department of Dermatology, St. Joseph Hospital, Ruhr-University of Bochum; C. Guenther, MD, Department of Dermatology, University Hospital Carl Gustav Carus; G. Zeidler, MD, Department of Rheumatology, Johanniter-Hospital; C. Pfeiffer, MD, Department of Dermatology, Ulm University Hospital; M. Worm, MD, Department of Dermatology, University of Berlin, Charité; S. Karrer, MD, Department of Dermatology, University Hospital Regensburg; E. Aberer, MD, Department of Dermatology, Medical University of Graz; A. Bretterklieber, MD, Department of Dermatology, Medical University of Graz; E. Genth, MD, Department of Rheumatology, Clinic of Rheumatology of Aachen; J.C. Simon, MD, Department of Dermatology, University Hospital Leipzig; J.H. Distler, MD, Department of Rheumatology, University Hospital Erlangen; R. Hein, MD, Department of Dermatology, TUM University Hospital; M. Schneider, MD, Department of Rheumatology and Nephrology, University Hospital Duesseldorf; C.S. Seitz, MD, Department of Dermatology, University Hospital Göttingen; C. Herink, MD, Department of Dermatology, University Hospital Göttingen; K. Steinbrink, MD, Department of Dermatology, University Medical Center, Johannes Gutenberg University; M. Sárdy, MD, Department of Dermatology, Ludwig Maximilian University; R. Varga, MD, Department of Dermatology, Ludwig Maximilian University; H. Mensing, MD, Clinic for Dermatology; C. Mensing, MD, Clinic for Dermatology; P. Lehmann, MD, Department of Dermatology, Helios Clinic; G. Neeck, MD, Center for Rheumatology Bad Doberan; C. Fiehn, MD, Center for Rheumatology Acura; M. Weber, MD, Department of Internal Medicine, Hospital of Cologne Merheim; M. Goebeler, MD, Department of Dermatology, University Hospital of Würzburg; H. Burkhardt, MD, Department of Rheumatology, University Hospital Frankfurt; M. Buslau, MD, Center for Rheumatology (Rehabilitation); K. Ahmadi-Simab, MD, Clinic for Internal Medicine, Klinikum Stephansplatz; A. Himsel, MD, Department of Rheumatology, GRP-Hospital Ruesselheim; A. Juche, MD, Department of Rheumatology, Immanuel Hospital; I. Koetter, MD, Department of Rheumatology, Asklepios Clinic Altona; A. Kuhn, MD, Division of Immunogenetics, German Cancer Research Center; M. Sticherling, MD, Department of Dermatology, University Hospital Erlangen; M. Hellmich, MD, Institute of Medical Statistics, Informatics and Epidemiology, University of Cologne; K. Kuhr, MD, Institute of Medical Statistics, Informatics and Epidemiology, University of Cologne; T. Krieg, MD, Department of Dermatology, University Hospital of Cologne; J. Ehrchen, MD, Department of Dermatology and Venereology, University Hospital Muenster; C. Sunderkoetter, MD, Department of Dermatology and Venereology, University Hospital Muenster; N. Hunzelmann, MD, Department of Dermatology, University Hospital of Cologne. Address correspondence to Dr. P. Moinzadeh, Department of Dermatology and Venereology, University of Cologne, Kerpener Str. 62, 50937 Cologne, Germany. E-mail: pia.moinzadeh@uk-koeln.de. Accepted for publication August 28, 2015.
Ina Koetter
From the Department of Dermatology, University Hospital of Cologne; Department of Internal Medicine, Hospital of Cologne Merheim; Institute of Medical Statistics, Informatics and Epidemiology, University of Cologne, Cologne; Department of Rheumatology, University Medical Center Schleswig-Holstein, Lübeck; Department of Rheumatology and Clinical Immunology, and Department of Dermatology, University of Berlin, Charité, Berlin; Department of Rheumatology, Immanuel Hospital, Berlin-Buch; Department of Dermatology, and Department of Rheumatology, University Hospital Tübingen, Tübingen; Department of Internal Medicine, Division of Rheumatology, Heidelberg University Hospital; Division of Immunogenetics, German Cancer Research Center, Heidelberg; Department of Rheumatology and Clinical Immunology, University Medical Center, Freiburg; Department of Rheumatology and Clinical Immunology, University of Giessen, Kerckhoff Clinic, Bad Nauheim; Department of Dermatology, HELIOS St. Elisabeth Clinic, Oberhausen; Department of Dermatology, St. Joseph Hospital, Ruhr- University of Bochum, Bochum; Department of Dermatology, University Hospital Carl Gustav Carus, Dresden; Department of Rheumatology, Johanniter-Hospital, Treuenbrietzen; Department of Dermatology, Ulm University Hospital, Ulm; Department of Dermatology, University Hospital Regensburg, Regensburg; Department of Rheumatology, Clinic of Rheumatology of Aachen, Aachen; Department of Dermatology, University Hospital Leipzig, Leipzig; Department of Rheumatology, and Department of Dermatology, University Hospital Erlangen, Erlangen; Department of Dermatology, TUM University Hospital; Department of Dermatology, Ludwig Maximilian University, Munich; Department of Rheumatology and Nephrology, University Hospital Duesseldorf, Duesseldorf; Department of Dermatology, University Hospital Göttingen, Göttingen; Department of Dermatology, University Medical Center, Johannes Gutenberg University, Mainz; Clinic for Dermatology, Hamburg Alstertal; Department of Dermatology, Helios Clinic, Wuppertal; Center for Rheumatology Bad Doberan, Bad Doberan; Center for Rheumatology Acura, Baden-Baden; Department of Dermatology, University Hospital of Würzburg, Würzburg; Department of Rheumatology, University Hospital Frankfurt, Frankfurt; Center for Rheumatology (Rehabilitation), Rheinfelden; Clinic for Internal Medicine, Klinikum Stephansplatz; Department of Rheumatology, Asklepios Clinic Altona, Hamburg; Department of Rheumatology, GRP-Hospital Ruesselheim, Darmstadt; Department of Dermatology and Venereology, University Hospital Muenster, Muenster, Germany; Department of Dermatology, Medical University of Graz, Graz, Austria. Supported by a grant of the German Federal Ministry of Education and Research (BMBF; 01GM0310 NH, TK; 01GM0631 CS) and the Edith Busch Foundation. The work of Pia Moinzadeh was supported by “Koeln Fortune” (155/2014) and “Deutsche Stiftung Sklerodermie” (3649/0096/31) grants. P. Moinzadeh, MD, Department of Dermatology, University Hospital of Cologne; G. Riemekasten, MD, Department of Rheumatology, University Medical Center Schleswig-Holstein; E. Siegert, Department of Rheumatology and Clinical Immunology, University of Berlin, Charité; G. Fierlbeck, MD, Department of Dermatology, University Hospital Tübingen; J. Henes, MD, Department of Rheumatology, University Hospital Tübingen; N. Blank, MD, Department of Internal Medicine, Division of Rheumatology, Heidelberg University Hospital; I. Melchers, MD, Department of Rheumatology and Clinical Immunology, University Medical Center; U. Mueller-Ladner, MD, Department of Rheumatology and Clinical Immunology, University of Giessen, Kerckhoff Clinic; M. Frerix, MD, Department of Rheumatology and Clinical Immunology, University of Giessen, Kerckhoff Clinic; A. Kreuter, MD, Department of Dermatology, HELIOS St. Elisabeth Clinic; C. Tigges, MD, Department of Dermatology, HELIOS St. Elisabeth Clinic; N. Lahner, MD, Department of Dermatology, St. Joseph Hospital, Ruhr-University of Bochum; L. Susok, MD, Department of Dermatology, St. Joseph Hospital, Ruhr-University of Bochum; C. Guenther, MD, Department of Dermatology, University Hospital Carl Gustav Carus; G. Zeidler, MD, Department of Rheumatology, Johanniter-Hospital; C. Pfeiffer, MD, Department of Dermatology, Ulm University Hospital; M. Worm, MD, Department of Dermatology, University of Berlin, Charité; S. Karrer, MD, Department of Dermatology, University Hospital Regensburg; E. Aberer, MD, Department of Dermatology, Medical University of Graz; A. Bretterklieber, MD, Department of Dermatology, Medical University of Graz; E. Genth, MD, Department of Rheumatology, Clinic of Rheumatology of Aachen; J.C. Simon, MD, Department of Dermatology, University Hospital Leipzig; J.H. Distler, MD, Department of Rheumatology, University Hospital Erlangen; R. Hein, MD, Department of Dermatology, TUM University Hospital; M. Schneider, MD, Department of Rheumatology and Nephrology, University Hospital Duesseldorf; C.S. Seitz, MD, Department of Dermatology, University Hospital Göttingen; C. Herink, MD, Department of Dermatology, University Hospital Göttingen; K. Steinbrink, MD, Department of Dermatology, University Medical Center, Johannes Gutenberg University; M. Sárdy, MD, Department of Dermatology, Ludwig Maximilian University; R. Varga, MD, Department of Dermatology, Ludwig Maximilian University; H. Mensing, MD, Clinic for Dermatology; C. Mensing, MD, Clinic for Dermatology; P. Lehmann, MD, Department of Dermatology, Helios Clinic; G. Neeck, MD, Center for Rheumatology Bad Doberan; C. Fiehn, MD, Center for Rheumatology Acura; M. Weber, MD, Department of Internal Medicine, Hospital of Cologne Merheim; M. Goebeler, MD, Department of Dermatology, University Hospital of Würzburg; H. Burkhardt, MD, Department of Rheumatology, University Hospital Frankfurt; M. Buslau, MD, Center for Rheumatology (Rehabilitation); K. Ahmadi-Simab, MD, Clinic for Internal Medicine, Klinikum Stephansplatz; A. Himsel, MD, Department of Rheumatology, GRP-Hospital Ruesselheim; A. Juche, MD, Department of Rheumatology, Immanuel Hospital; I. Koetter, MD, Department of Rheumatology, Asklepios Clinic Altona; A. Kuhn, MD, Division of Immunogenetics, German Cancer Research Center; M. Sticherling, MD, Department of Dermatology, University Hospital Erlangen; M. Hellmich, MD, Institute of Medical Statistics, Informatics and Epidemiology, University of Cologne; K. Kuhr, MD, Institute of Medical Statistics, Informatics and Epidemiology, University of Cologne; T. Krieg, MD, Department of Dermatology, University Hospital of Cologne; J. Ehrchen, MD, Department of Dermatology and Venereology, University Hospital Muenster; C. Sunderkoetter, MD, Department of Dermatology and Venereology, University Hospital Muenster; N. Hunzelmann, MD, Department of Dermatology, University Hospital of Cologne. Address correspondence to Dr. P. Moinzadeh, Department of Dermatology and Venereology, University of Cologne, Kerpener Str. 62, 50937 Cologne, Germany. E-mail: pia.moinzadeh@uk-koeln.de. Accepted for publication August 28, 2015.
Annegret Kuhn
From the Department of Dermatology, University Hospital of Cologne; Department of Internal Medicine, Hospital of Cologne Merheim; Institute of Medical Statistics, Informatics and Epidemiology, University of Cologne, Cologne; Department of Rheumatology, University Medical Center Schleswig-Holstein, Lübeck; Department of Rheumatology and Clinical Immunology, and Department of Dermatology, University of Berlin, Charité, Berlin; Department of Rheumatology, Immanuel Hospital, Berlin-Buch; Department of Dermatology, and Department of Rheumatology, University Hospital Tübingen, Tübingen; Department of Internal Medicine, Division of Rheumatology, Heidelberg University Hospital; Division of Immunogenetics, German Cancer Research Center, Heidelberg; Department of Rheumatology and Clinical Immunology, University Medical Center, Freiburg; Department of Rheumatology and Clinical Immunology, University of Giessen, Kerckhoff Clinic, Bad Nauheim; Department of Dermatology, HELIOS St. Elisabeth Clinic, Oberhausen; Department of Dermatology, St. Joseph Hospital, Ruhr- University of Bochum, Bochum; Department of Dermatology, University Hospital Carl Gustav Carus, Dresden; Department of Rheumatology, Johanniter-Hospital, Treuenbrietzen; Department of Dermatology, Ulm University Hospital, Ulm; Department of Dermatology, University Hospital Regensburg, Regensburg; Department of Rheumatology, Clinic of Rheumatology of Aachen, Aachen; Department of Dermatology, University Hospital Leipzig, Leipzig; Department of Rheumatology, and Department of Dermatology, University Hospital Erlangen, Erlangen; Department of Dermatology, TUM University Hospital; Department of Dermatology, Ludwig Maximilian University, Munich; Department of Rheumatology and Nephrology, University Hospital Duesseldorf, Duesseldorf; Department of Dermatology, University Hospital Göttingen, Göttingen; Department of Dermatology, University Medical Center, Johannes Gutenberg University, Mainz; Clinic for Dermatology, Hamburg Alstertal; Department of Dermatology, Helios Clinic, Wuppertal; Center for Rheumatology Bad Doberan, Bad Doberan; Center for Rheumatology Acura, Baden-Baden; Department of Dermatology, University Hospital of Würzburg, Würzburg; Department of Rheumatology, University Hospital Frankfurt, Frankfurt; Center for Rheumatology (Rehabilitation), Rheinfelden; Clinic for Internal Medicine, Klinikum Stephansplatz; Department of Rheumatology, Asklepios Clinic Altona, Hamburg; Department of Rheumatology, GRP-Hospital Ruesselheim, Darmstadt; Department of Dermatology and Venereology, University Hospital Muenster, Muenster, Germany; Department of Dermatology, Medical University of Graz, Graz, Austria. Supported by a grant of the German Federal Ministry of Education and Research (BMBF; 01GM0310 NH, TK; 01GM0631 CS) and the Edith Busch Foundation. The work of Pia Moinzadeh was supported by “Koeln Fortune” (155/2014) and “Deutsche Stiftung Sklerodermie” (3649/0096/31) grants. P. Moinzadeh, MD, Department of Dermatology, University Hospital of Cologne; G. Riemekasten, MD, Department of Rheumatology, University Medical Center Schleswig-Holstein; E. Siegert, Department of Rheumatology and Clinical Immunology, University of Berlin, Charité; G. Fierlbeck, MD, Department of Dermatology, University Hospital Tübingen; J. Henes, MD, Department of Rheumatology, University Hospital Tübingen; N. Blank, MD, Department of Internal Medicine, Division of Rheumatology, Heidelberg University Hospital; I. Melchers, MD, Department of Rheumatology and Clinical Immunology, University Medical Center; U. Mueller-Ladner, MD, Department of Rheumatology and Clinical Immunology, University of Giessen, Kerckhoff Clinic; M. Frerix, MD, Department of Rheumatology and Clinical Immunology, University of Giessen, Kerckhoff Clinic; A. Kreuter, MD, Department of Dermatology, HELIOS St. Elisabeth Clinic; C. Tigges, MD, Department of Dermatology, HELIOS St. Elisabeth Clinic; N. Lahner, MD, Department of Dermatology, St. Joseph Hospital, Ruhr-University of Bochum; L. Susok, MD, Department of Dermatology, St. Joseph Hospital, Ruhr-University of Bochum; C. Guenther, MD, Department of Dermatology, University Hospital Carl Gustav Carus; G. Zeidler, MD, Department of Rheumatology, Johanniter-Hospital; C. Pfeiffer, MD, Department of Dermatology, Ulm University Hospital; M. Worm, MD, Department of Dermatology, University of Berlin, Charité; S. Karrer, MD, Department of Dermatology, University Hospital Regensburg; E. Aberer, MD, Department of Dermatology, Medical University of Graz; A. Bretterklieber, MD, Department of Dermatology, Medical University of Graz; E. Genth, MD, Department of Rheumatology, Clinic of Rheumatology of Aachen; J.C. Simon, MD, Department of Dermatology, University Hospital Leipzig; J.H. Distler, MD, Department of Rheumatology, University Hospital Erlangen; R. Hein, MD, Department of Dermatology, TUM University Hospital; M. Schneider, MD, Department of Rheumatology and Nephrology, University Hospital Duesseldorf; C.S. Seitz, MD, Department of Dermatology, University Hospital Göttingen; C. Herink, MD, Department of Dermatology, University Hospital Göttingen; K. Steinbrink, MD, Department of Dermatology, University Medical Center, Johannes Gutenberg University; M. Sárdy, MD, Department of Dermatology, Ludwig Maximilian University; R. Varga, MD, Department of Dermatology, Ludwig Maximilian University; H. Mensing, MD, Clinic for Dermatology; C. Mensing, MD, Clinic for Dermatology; P. Lehmann, MD, Department of Dermatology, Helios Clinic; G. Neeck, MD, Center for Rheumatology Bad Doberan; C. Fiehn, MD, Center for Rheumatology Acura; M. Weber, MD, Department of Internal Medicine, Hospital of Cologne Merheim; M. Goebeler, MD, Department of Dermatology, University Hospital of Würzburg; H. Burkhardt, MD, Department of Rheumatology, University Hospital Frankfurt; M. Buslau, MD, Center for Rheumatology (Rehabilitation); K. Ahmadi-Simab, MD, Clinic for Internal Medicine, Klinikum Stephansplatz; A. Himsel, MD, Department of Rheumatology, GRP-Hospital Ruesselheim; A. Juche, MD, Department of Rheumatology, Immanuel Hospital; I. Koetter, MD, Department of Rheumatology, Asklepios Clinic Altona; A. Kuhn, MD, Division of Immunogenetics, German Cancer Research Center; M. Sticherling, MD, Department of Dermatology, University Hospital Erlangen; M. Hellmich, MD, Institute of Medical Statistics, Informatics and Epidemiology, University of Cologne; K. Kuhr, MD, Institute of Medical Statistics, Informatics and Epidemiology, University of Cologne; T. Krieg, MD, Department of Dermatology, University Hospital of Cologne; J. Ehrchen, MD, Department of Dermatology and Venereology, University Hospital Muenster; C. Sunderkoetter, MD, Department of Dermatology and Venereology, University Hospital Muenster; N. Hunzelmann, MD, Department of Dermatology, University Hospital of Cologne. Address correspondence to Dr. P. Moinzadeh, Department of Dermatology and Venereology, University of Cologne, Kerpener Str. 62, 50937 Cologne, Germany. E-mail: pia.moinzadeh@uk-koeln.de. Accepted for publication August 28, 2015.
Michael Sticherling
From the Department of Dermatology, University Hospital of Cologne; Department of Internal Medicine, Hospital of Cologne Merheim; Institute of Medical Statistics, Informatics and Epidemiology, University of Cologne, Cologne; Department of Rheumatology, University Medical Center Schleswig-Holstein, Lübeck; Department of Rheumatology and Clinical Immunology, and Department of Dermatology, University of Berlin, Charité, Berlin; Department of Rheumatology, Immanuel Hospital, Berlin-Buch; Department of Dermatology, and Department of Rheumatology, University Hospital Tübingen, Tübingen; Department of Internal Medicine, Division of Rheumatology, Heidelberg University Hospital; Division of Immunogenetics, German Cancer Research Center, Heidelberg; Department of Rheumatology and Clinical Immunology, University Medical Center, Freiburg; Department of Rheumatology and Clinical Immunology, University of Giessen, Kerckhoff Clinic, Bad Nauheim; Department of Dermatology, HELIOS St. Elisabeth Clinic, Oberhausen; Department of Dermatology, St. Joseph Hospital, Ruhr- University of Bochum, Bochum; Department of Dermatology, University Hospital Carl Gustav Carus, Dresden; Department of Rheumatology, Johanniter-Hospital, Treuenbrietzen; Department of Dermatology, Ulm University Hospital, Ulm; Department of Dermatology, University Hospital Regensburg, Regensburg; Department of Rheumatology, Clinic of Rheumatology of Aachen, Aachen; Department of Dermatology, University Hospital Leipzig, Leipzig; Department of Rheumatology, and Department of Dermatology, University Hospital Erlangen, Erlangen; Department of Dermatology, TUM University Hospital; Department of Dermatology, Ludwig Maximilian University, Munich; Department of Rheumatology and Nephrology, University Hospital Duesseldorf, Duesseldorf; Department of Dermatology, University Hospital Göttingen, Göttingen; Department of Dermatology, University Medical Center, Johannes Gutenberg University, Mainz; Clinic for Dermatology, Hamburg Alstertal; Department of Dermatology, Helios Clinic, Wuppertal; Center for Rheumatology Bad Doberan, Bad Doberan; Center for Rheumatology Acura, Baden-Baden; Department of Dermatology, University Hospital of Würzburg, Würzburg; Department of Rheumatology, University Hospital Frankfurt, Frankfurt; Center for Rheumatology (Rehabilitation), Rheinfelden; Clinic for Internal Medicine, Klinikum Stephansplatz; Department of Rheumatology, Asklepios Clinic Altona, Hamburg; Department of Rheumatology, GRP-Hospital Ruesselheim, Darmstadt; Department of Dermatology and Venereology, University Hospital Muenster, Muenster, Germany; Department of Dermatology, Medical University of Graz, Graz, Austria. Supported by a grant of the German Federal Ministry of Education and Research (BMBF; 01GM0310 NH, TK; 01GM0631 CS) and the Edith Busch Foundation. The work of Pia Moinzadeh was supported by “Koeln Fortune” (155/2014) and “Deutsche Stiftung Sklerodermie” (3649/0096/31) grants. P. Moinzadeh, MD, Department of Dermatology, University Hospital of Cologne; G. Riemekasten, MD, Department of Rheumatology, University Medical Center Schleswig-Holstein; E. Siegert, Department of Rheumatology and Clinical Immunology, University of Berlin, Charité; G. Fierlbeck, MD, Department of Dermatology, University Hospital Tübingen; J. Henes, MD, Department of Rheumatology, University Hospital Tübingen; N. Blank, MD, Department of Internal Medicine, Division of Rheumatology, Heidelberg University Hospital; I. Melchers, MD, Department of Rheumatology and Clinical Immunology, University Medical Center; U. Mueller-Ladner, MD, Department of Rheumatology and Clinical Immunology, University of Giessen, Kerckhoff Clinic; M. Frerix, MD, Department of Rheumatology and Clinical Immunology, University of Giessen, Kerckhoff Clinic; A. Kreuter, MD, Department of Dermatology, HELIOS St. Elisabeth Clinic; C. Tigges, MD, Department of Dermatology, HELIOS St. Elisabeth Clinic; N. Lahner, MD, Department of Dermatology, St. Joseph Hospital, Ruhr-University of Bochum; L. Susok, MD, Department of Dermatology, St. Joseph Hospital, Ruhr-University of Bochum; C. Guenther, MD, Department of Dermatology, University Hospital Carl Gustav Carus; G. Zeidler, MD, Department of Rheumatology, Johanniter-Hospital; C. Pfeiffer, MD, Department of Dermatology, Ulm University Hospital; M. Worm, MD, Department of Dermatology, University of Berlin, Charité; S. Karrer, MD, Department of Dermatology, University Hospital Regensburg; E. Aberer, MD, Department of Dermatology, Medical University of Graz; A. Bretterklieber, MD, Department of Dermatology, Medical University of Graz; E. Genth, MD, Department of Rheumatology, Clinic of Rheumatology of Aachen; J.C. Simon, MD, Department of Dermatology, University Hospital Leipzig; J.H. Distler, MD, Department of Rheumatology, University Hospital Erlangen; R. Hein, MD, Department of Dermatology, TUM University Hospital; M. Schneider, MD, Department of Rheumatology and Nephrology, University Hospital Duesseldorf; C.S. Seitz, MD, Department of Dermatology, University Hospital Göttingen; C. Herink, MD, Department of Dermatology, University Hospital Göttingen; K. Steinbrink, MD, Department of Dermatology, University Medical Center, Johannes Gutenberg University; M. Sárdy, MD, Department of Dermatology, Ludwig Maximilian University; R. Varga, MD, Department of Dermatology, Ludwig Maximilian University; H. Mensing, MD, Clinic for Dermatology; C. Mensing, MD, Clinic for Dermatology; P. Lehmann, MD, Department of Dermatology, Helios Clinic; G. Neeck, MD, Center for Rheumatology Bad Doberan; C. Fiehn, MD, Center for Rheumatology Acura; M. Weber, MD, Department of Internal Medicine, Hospital of Cologne Merheim; M. Goebeler, MD, Department of Dermatology, University Hospital of Würzburg; H. Burkhardt, MD, Department of Rheumatology, University Hospital Frankfurt; M. Buslau, MD, Center for Rheumatology (Rehabilitation); K. Ahmadi-Simab, MD, Clinic for Internal Medicine, Klinikum Stephansplatz; A. Himsel, MD, Department of Rheumatology, GRP-Hospital Ruesselheim; A. Juche, MD, Department of Rheumatology, Immanuel Hospital; I. Koetter, MD, Department of Rheumatology, Asklepios Clinic Altona; A. Kuhn, MD, Division of Immunogenetics, German Cancer Research Center; M. Sticherling, MD, Department of Dermatology, University Hospital Erlangen; M. Hellmich, MD, Institute of Medical Statistics, Informatics and Epidemiology, University of Cologne; K. Kuhr, MD, Institute of Medical Statistics, Informatics and Epidemiology, University of Cologne; T. Krieg, MD, Department of Dermatology, University Hospital of Cologne; J. Ehrchen, MD, Department of Dermatology and Venereology, University Hospital Muenster; C. Sunderkoetter, MD, Department of Dermatology and Venereology, University Hospital Muenster; N. Hunzelmann, MD, Department of Dermatology, University Hospital of Cologne. Address correspondence to Dr. P. Moinzadeh, Department of Dermatology and Venereology, University of Cologne, Kerpener Str. 62, 50937 Cologne, Germany. E-mail: pia.moinzadeh@uk-koeln.de. Accepted for publication August 28, 2015.
Martin Hellmich
From the Department of Dermatology, University Hospital of Cologne; Department of Internal Medicine, Hospital of Cologne Merheim; Institute of Medical Statistics, Informatics and Epidemiology, University of Cologne, Cologne; Department of Rheumatology, University Medical Center Schleswig-Holstein, Lübeck; Department of Rheumatology and Clinical Immunology, and Department of Dermatology, University of Berlin, Charité, Berlin; Department of Rheumatology, Immanuel Hospital, Berlin-Buch; Department of Dermatology, and Department of Rheumatology, University Hospital Tübingen, Tübingen; Department of Internal Medicine, Division of Rheumatology, Heidelberg University Hospital; Division of Immunogenetics, German Cancer Research Center, Heidelberg; Department of Rheumatology and Clinical Immunology, University Medical Center, Freiburg; Department of Rheumatology and Clinical Immunology, University of Giessen, Kerckhoff Clinic, Bad Nauheim; Department of Dermatology, HELIOS St. Elisabeth Clinic, Oberhausen; Department of Dermatology, St. Joseph Hospital, Ruhr- University of Bochum, Bochum; Department of Dermatology, University Hospital Carl Gustav Carus, Dresden; Department of Rheumatology, Johanniter-Hospital, Treuenbrietzen; Department of Dermatology, Ulm University Hospital, Ulm; Department of Dermatology, University Hospital Regensburg, Regensburg; Department of Rheumatology, Clinic of Rheumatology of Aachen, Aachen; Department of Dermatology, University Hospital Leipzig, Leipzig; Department of Rheumatology, and Department of Dermatology, University Hospital Erlangen, Erlangen; Department of Dermatology, TUM University Hospital; Department of Dermatology, Ludwig Maximilian University, Munich; Department of Rheumatology and Nephrology, University Hospital Duesseldorf, Duesseldorf; Department of Dermatology, University Hospital Göttingen, Göttingen; Department of Dermatology, University Medical Center, Johannes Gutenberg University, Mainz; Clinic for Dermatology, Hamburg Alstertal; Department of Dermatology, Helios Clinic, Wuppertal; Center for Rheumatology Bad Doberan, Bad Doberan; Center for Rheumatology Acura, Baden-Baden; Department of Dermatology, University Hospital of Würzburg, Würzburg; Department of Rheumatology, University Hospital Frankfurt, Frankfurt; Center for Rheumatology (Rehabilitation), Rheinfelden; Clinic for Internal Medicine, Klinikum Stephansplatz; Department of Rheumatology, Asklepios Clinic Altona, Hamburg; Department of Rheumatology, GRP-Hospital Ruesselheim, Darmstadt; Department of Dermatology and Venereology, University Hospital Muenster, Muenster, Germany; Department of Dermatology, Medical University of Graz, Graz, Austria. Supported by a grant of the German Federal Ministry of Education and Research (BMBF; 01GM0310 NH, TK; 01GM0631 CS) and the Edith Busch Foundation. The work of Pia Moinzadeh was supported by “Koeln Fortune” (155/2014) and “Deutsche Stiftung Sklerodermie” (3649/0096/31) grants. P. Moinzadeh, MD, Department of Dermatology, University Hospital of Cologne; G. Riemekasten, MD, Department of Rheumatology, University Medical Center Schleswig-Holstein; E. Siegert, Department of Rheumatology and Clinical Immunology, University of Berlin, Charité; G. Fierlbeck, MD, Department of Dermatology, University Hospital Tübingen; J. Henes, MD, Department of Rheumatology, University Hospital Tübingen; N. Blank, MD, Department of Internal Medicine, Division of Rheumatology, Heidelberg University Hospital; I. Melchers, MD, Department of Rheumatology and Clinical Immunology, University Medical Center; U. Mueller-Ladner, MD, Department of Rheumatology and Clinical Immunology, University of Giessen, Kerckhoff Clinic; M. Frerix, MD, Department of Rheumatology and Clinical Immunology, University of Giessen, Kerckhoff Clinic; A. Kreuter, MD, Department of Dermatology, HELIOS St. Elisabeth Clinic; C. Tigges, MD, Department of Dermatology, HELIOS St. Elisabeth Clinic; N. Lahner, MD, Department of Dermatology, St. Joseph Hospital, Ruhr-University of Bochum; L. Susok, MD, Department of Dermatology, St. Joseph Hospital, Ruhr-University of Bochum; C. Guenther, MD, Department of Dermatology, University Hospital Carl Gustav Carus; G. Zeidler, MD, Department of Rheumatology, Johanniter-Hospital; C. Pfeiffer, MD, Department of Dermatology, Ulm University Hospital; M. Worm, MD, Department of Dermatology, University of Berlin, Charité; S. Karrer, MD, Department of Dermatology, University Hospital Regensburg; E. Aberer, MD, Department of Dermatology, Medical University of Graz; A. Bretterklieber, MD, Department of Dermatology, Medical University of Graz; E. Genth, MD, Department of Rheumatology, Clinic of Rheumatology of Aachen; J.C. Simon, MD, Department of Dermatology, University Hospital Leipzig; J.H. Distler, MD, Department of Rheumatology, University Hospital Erlangen; R. Hein, MD, Department of Dermatology, TUM University Hospital; M. Schneider, MD, Department of Rheumatology and Nephrology, University Hospital Duesseldorf; C.S. Seitz, MD, Department of Dermatology, University Hospital Göttingen; C. Herink, MD, Department of Dermatology, University Hospital Göttingen; K. Steinbrink, MD, Department of Dermatology, University Medical Center, Johannes Gutenberg University; M. Sárdy, MD, Department of Dermatology, Ludwig Maximilian University; R. Varga, MD, Department of Dermatology, Ludwig Maximilian University; H. Mensing, MD, Clinic for Dermatology; C. Mensing, MD, Clinic for Dermatology; P. Lehmann, MD, Department of Dermatology, Helios Clinic; G. Neeck, MD, Center for Rheumatology Bad Doberan; C. Fiehn, MD, Center for Rheumatology Acura; M. Weber, MD, Department of Internal Medicine, Hospital of Cologne Merheim; M. Goebeler, MD, Department of Dermatology, University Hospital of Würzburg; H. Burkhardt, MD, Department of Rheumatology, University Hospital Frankfurt; M. Buslau, MD, Center for Rheumatology (Rehabilitation); K. Ahmadi-Simab, MD, Clinic for Internal Medicine, Klinikum Stephansplatz; A. Himsel, MD, Department of Rheumatology, GRP-Hospital Ruesselheim; A. Juche, MD, Department of Rheumatology, Immanuel Hospital; I. Koetter, MD, Department of Rheumatology, Asklepios Clinic Altona; A. Kuhn, MD, Division of Immunogenetics, German Cancer Research Center; M. Sticherling, MD, Department of Dermatology, University Hospital Erlangen; M. Hellmich, MD, Institute of Medical Statistics, Informatics and Epidemiology, University of Cologne; K. Kuhr, MD, Institute of Medical Statistics, Informatics and Epidemiology, University of Cologne; T. Krieg, MD, Department of Dermatology, University Hospital of Cologne; J. Ehrchen, MD, Department of Dermatology and Venereology, University Hospital Muenster; C. Sunderkoetter, MD, Department of Dermatology and Venereology, University Hospital Muenster; N. Hunzelmann, MD, Department of Dermatology, University Hospital of Cologne. Address correspondence to Dr. P. Moinzadeh, Department of Dermatology and Venereology, University of Cologne, Kerpener Str. 62, 50937 Cologne, Germany. E-mail: pia.moinzadeh@uk-koeln.de. Accepted for publication August 28, 2015.
Kathrin Kuhr
From the Department of Dermatology, University Hospital of Cologne; Department of Internal Medicine, Hospital of Cologne Merheim; Institute of Medical Statistics, Informatics and Epidemiology, University of Cologne, Cologne; Department of Rheumatology, University Medical Center Schleswig-Holstein, Lübeck; Department of Rheumatology and Clinical Immunology, and Department of Dermatology, University of Berlin, Charité, Berlin; Department of Rheumatology, Immanuel Hospital, Berlin-Buch; Department of Dermatology, and Department of Rheumatology, University Hospital Tübingen, Tübingen; Department of Internal Medicine, Division of Rheumatology, Heidelberg University Hospital; Division of Immunogenetics, German Cancer Research Center, Heidelberg; Department of Rheumatology and Clinical Immunology, University Medical Center, Freiburg; Department of Rheumatology and Clinical Immunology, University of Giessen, Kerckhoff Clinic, Bad Nauheim; Department of Dermatology, HELIOS St. Elisabeth Clinic, Oberhausen; Department of Dermatology, St. Joseph Hospital, Ruhr- University of Bochum, Bochum; Department of Dermatology, University Hospital Carl Gustav Carus, Dresden; Department of Rheumatology, Johanniter-Hospital, Treuenbrietzen; Department of Dermatology, Ulm University Hospital, Ulm; Department of Dermatology, University Hospital Regensburg, Regensburg; Department of Rheumatology, Clinic of Rheumatology of Aachen, Aachen; Department of Dermatology, University Hospital Leipzig, Leipzig; Department of Rheumatology, and Department of Dermatology, University Hospital Erlangen, Erlangen; Department of Dermatology, TUM University Hospital; Department of Dermatology, Ludwig Maximilian University, Munich; Department of Rheumatology and Nephrology, University Hospital Duesseldorf, Duesseldorf; Department of Dermatology, University Hospital Göttingen, Göttingen; Department of Dermatology, University Medical Center, Johannes Gutenberg University, Mainz; Clinic for Dermatology, Hamburg Alstertal; Department of Dermatology, Helios Clinic, Wuppertal; Center for Rheumatology Bad Doberan, Bad Doberan; Center for Rheumatology Acura, Baden-Baden; Department of Dermatology, University Hospital of Würzburg, Würzburg; Department of Rheumatology, University Hospital Frankfurt, Frankfurt; Center for Rheumatology (Rehabilitation), Rheinfelden; Clinic for Internal Medicine, Klinikum Stephansplatz; Department of Rheumatology, Asklepios Clinic Altona, Hamburg; Department of Rheumatology, GRP-Hospital Ruesselheim, Darmstadt; Department of Dermatology and Venereology, University Hospital Muenster, Muenster, Germany; Department of Dermatology, Medical University of Graz, Graz, Austria. Supported by a grant of the German Federal Ministry of Education and Research (BMBF; 01GM0310 NH, TK; 01GM0631 CS) and the Edith Busch Foundation. The work of Pia Moinzadeh was supported by “Koeln Fortune” (155/2014) and “Deutsche Stiftung Sklerodermie” (3649/0096/31) grants. P. Moinzadeh, MD, Department of Dermatology, University Hospital of Cologne; G. Riemekasten, MD, Department of Rheumatology, University Medical Center Schleswig-Holstein; E. Siegert, Department of Rheumatology and Clinical Immunology, University of Berlin, Charité; G. Fierlbeck, MD, Department of Dermatology, University Hospital Tübingen; J. Henes, MD, Department of Rheumatology, University Hospital Tübingen; N. Blank, MD, Department of Internal Medicine, Division of Rheumatology, Heidelberg University Hospital; I. Melchers, MD, Department of Rheumatology and Clinical Immunology, University Medical Center; U. Mueller-Ladner, MD, Department of Rheumatology and Clinical Immunology, University of Giessen, Kerckhoff Clinic; M. Frerix, MD, Department of Rheumatology and Clinical Immunology, University of Giessen, Kerckhoff Clinic; A. Kreuter, MD, Department of Dermatology, HELIOS St. Elisabeth Clinic; C. Tigges, MD, Department of Dermatology, HELIOS St. Elisabeth Clinic; N. Lahner, MD, Department of Dermatology, St. Joseph Hospital, Ruhr-University of Bochum; L. Susok, MD, Department of Dermatology, St. Joseph Hospital, Ruhr-University of Bochum; C. Guenther, MD, Department of Dermatology, University Hospital Carl Gustav Carus; G. Zeidler, MD, Department of Rheumatology, Johanniter-Hospital; C. Pfeiffer, MD, Department of Dermatology, Ulm University Hospital; M. Worm, MD, Department of Dermatology, University of Berlin, Charité; S. Karrer, MD, Department of Dermatology, University Hospital Regensburg; E. Aberer, MD, Department of Dermatology, Medical University of Graz; A. Bretterklieber, MD, Department of Dermatology, Medical University of Graz; E. Genth, MD, Department of Rheumatology, Clinic of Rheumatology of Aachen; J.C. Simon, MD, Department of Dermatology, University Hospital Leipzig; J.H. Distler, MD, Department of Rheumatology, University Hospital Erlangen; R. Hein, MD, Department of Dermatology, TUM University Hospital; M. Schneider, MD, Department of Rheumatology and Nephrology, University Hospital Duesseldorf; C.S. Seitz, MD, Department of Dermatology, University Hospital Göttingen; C. Herink, MD, Department of Dermatology, University Hospital Göttingen; K. Steinbrink, MD, Department of Dermatology, University Medical Center, Johannes Gutenberg University; M. Sárdy, MD, Department of Dermatology, Ludwig Maximilian University; R. Varga, MD, Department of Dermatology, Ludwig Maximilian University; H. Mensing, MD, Clinic for Dermatology; C. Mensing, MD, Clinic for Dermatology; P. Lehmann, MD, Department of Dermatology, Helios Clinic; G. Neeck, MD, Center for Rheumatology Bad Doberan; C. Fiehn, MD, Center for Rheumatology Acura; M. Weber, MD, Department of Internal Medicine, Hospital of Cologne Merheim; M. Goebeler, MD, Department of Dermatology, University Hospital of Würzburg; H. Burkhardt, MD, Department of Rheumatology, University Hospital Frankfurt; M. Buslau, MD, Center for Rheumatology (Rehabilitation); K. Ahmadi-Simab, MD, Clinic for Internal Medicine, Klinikum Stephansplatz; A. Himsel, MD, Department of Rheumatology, GRP-Hospital Ruesselheim; A. Juche, MD, Department of Rheumatology, Immanuel Hospital; I. Koetter, MD, Department of Rheumatology, Asklepios Clinic Altona; A. Kuhn, MD, Division of Immunogenetics, German Cancer Research Center; M. Sticherling, MD, Department of Dermatology, University Hospital Erlangen; M. Hellmich, MD, Institute of Medical Statistics, Informatics and Epidemiology, University of Cologne; K. Kuhr, MD, Institute of Medical Statistics, Informatics and Epidemiology, University of Cologne; T. Krieg, MD, Department of Dermatology, University Hospital of Cologne; J. Ehrchen, MD, Department of Dermatology and Venereology, University Hospital Muenster; C. Sunderkoetter, MD, Department of Dermatology and Venereology, University Hospital Muenster; N. Hunzelmann, MD, Department of Dermatology, University Hospital of Cologne. Address correspondence to Dr. P. Moinzadeh, Department of Dermatology and Venereology, University of Cologne, Kerpener Str. 62, 50937 Cologne, Germany. E-mail: pia.moinzadeh@uk-koeln.de. Accepted for publication August 28, 2015.
Thomas Krieg
From the Department of Dermatology, University Hospital of Cologne; Department of Internal Medicine, Hospital of Cologne Merheim; Institute of Medical Statistics, Informatics and Epidemiology, University of Cologne, Cologne; Department of Rheumatology, University Medical Center Schleswig-Holstein, Lübeck; Department of Rheumatology and Clinical Immunology, and Department of Dermatology, University of Berlin, Charité, Berlin; Department of Rheumatology, Immanuel Hospital, Berlin-Buch; Department of Dermatology, and Department of Rheumatology, University Hospital Tübingen, Tübingen; Department of Internal Medicine, Division of Rheumatology, Heidelberg University Hospital; Division of Immunogenetics, German Cancer Research Center, Heidelberg; Department of Rheumatology and Clinical Immunology, University Medical Center, Freiburg; Department of Rheumatology and Clinical Immunology, University of Giessen, Kerckhoff Clinic, Bad Nauheim; Department of Dermatology, HELIOS St. Elisabeth Clinic, Oberhausen; Department of Dermatology, St. Joseph Hospital, Ruhr- University of Bochum, Bochum; Department of Dermatology, University Hospital Carl Gustav Carus, Dresden; Department of Rheumatology, Johanniter-Hospital, Treuenbrietzen; Department of Dermatology, Ulm University Hospital, Ulm; Department of Dermatology, University Hospital Regensburg, Regensburg; Department of Rheumatology, Clinic of Rheumatology of Aachen, Aachen; Department of Dermatology, University Hospital Leipzig, Leipzig; Department of Rheumatology, and Department of Dermatology, University Hospital Erlangen, Erlangen; Department of Dermatology, TUM University Hospital; Department of Dermatology, Ludwig Maximilian University, Munich; Department of Rheumatology and Nephrology, University Hospital Duesseldorf, Duesseldorf; Department of Dermatology, University Hospital Göttingen, Göttingen; Department of Dermatology, University Medical Center, Johannes Gutenberg University, Mainz; Clinic for Dermatology, Hamburg Alstertal; Department of Dermatology, Helios Clinic, Wuppertal; Center for Rheumatology Bad Doberan, Bad Doberan; Center for Rheumatology Acura, Baden-Baden; Department of Dermatology, University Hospital of Würzburg, Würzburg; Department of Rheumatology, University Hospital Frankfurt, Frankfurt; Center for Rheumatology (Rehabilitation), Rheinfelden; Clinic for Internal Medicine, Klinikum Stephansplatz; Department of Rheumatology, Asklepios Clinic Altona, Hamburg; Department of Rheumatology, GRP-Hospital Ruesselheim, Darmstadt; Department of Dermatology and Venereology, University Hospital Muenster, Muenster, Germany; Department of Dermatology, Medical University of Graz, Graz, Austria. Supported by a grant of the German Federal Ministry of Education and Research (BMBF; 01GM0310 NH, TK; 01GM0631 CS) and the Edith Busch Foundation. The work of Pia Moinzadeh was supported by “Koeln Fortune” (155/2014) and “Deutsche Stiftung Sklerodermie” (3649/0096/31) grants. P. Moinzadeh, MD, Department of Dermatology, University Hospital of Cologne; G. Riemekasten, MD, Department of Rheumatology, University Medical Center Schleswig-Holstein; E. Siegert, Department of Rheumatology and Clinical Immunology, University of Berlin, Charité; G. Fierlbeck, MD, Department of Dermatology, University Hospital Tübingen; J. Henes, MD, Department of Rheumatology, University Hospital Tübingen; N. Blank, MD, Department of Internal Medicine, Division of Rheumatology, Heidelberg University Hospital; I. Melchers, MD, Department of Rheumatology and Clinical Immunology, University Medical Center; U. Mueller-Ladner, MD, Department of Rheumatology and Clinical Immunology, University of Giessen, Kerckhoff Clinic; M. Frerix, MD, Department of Rheumatology and Clinical Immunology, University of Giessen, Kerckhoff Clinic; A. Kreuter, MD, Department of Dermatology, HELIOS St. Elisabeth Clinic; C. Tigges, MD, Department of Dermatology, HELIOS St. Elisabeth Clinic; N. Lahner, MD, Department of Dermatology, St. Joseph Hospital, Ruhr-University of Bochum; L. Susok, MD, Department of Dermatology, St. Joseph Hospital, Ruhr-University of Bochum; C. Guenther, MD, Department of Dermatology, University Hospital Carl Gustav Carus; G. Zeidler, MD, Department of Rheumatology, Johanniter-Hospital; C. Pfeiffer, MD, Department of Dermatology, Ulm University Hospital; M. Worm, MD, Department of Dermatology, University of Berlin, Charité; S. Karrer, MD, Department of Dermatology, University Hospital Regensburg; E. Aberer, MD, Department of Dermatology, Medical University of Graz; A. Bretterklieber, MD, Department of Dermatology, Medical University of Graz; E. Genth, MD, Department of Rheumatology, Clinic of Rheumatology of Aachen; J.C. Simon, MD, Department of Dermatology, University Hospital Leipzig; J.H. Distler, MD, Department of Rheumatology, University Hospital Erlangen; R. Hein, MD, Department of Dermatology, TUM University Hospital; M. Schneider, MD, Department of Rheumatology and Nephrology, University Hospital Duesseldorf; C.S. Seitz, MD, Department of Dermatology, University Hospital Göttingen; C. Herink, MD, Department of Dermatology, University Hospital Göttingen; K. Steinbrink, MD, Department of Dermatology, University Medical Center, Johannes Gutenberg University; M. Sárdy, MD, Department of Dermatology, Ludwig Maximilian University; R. Varga, MD, Department of Dermatology, Ludwig Maximilian University; H. Mensing, MD, Clinic for Dermatology; C. Mensing, MD, Clinic for Dermatology; P. Lehmann, MD, Department of Dermatology, Helios Clinic; G. Neeck, MD, Center for Rheumatology Bad Doberan; C. Fiehn, MD, Center for Rheumatology Acura; M. Weber, MD, Department of Internal Medicine, Hospital of Cologne Merheim; M. Goebeler, MD, Department of Dermatology, University Hospital of Würzburg; H. Burkhardt, MD, Department of Rheumatology, University Hospital Frankfurt; M. Buslau, MD, Center for Rheumatology (Rehabilitation); K. Ahmadi-Simab, MD, Clinic for Internal Medicine, Klinikum Stephansplatz; A. Himsel, MD, Department of Rheumatology, GRP-Hospital Ruesselheim; A. Juche, MD, Department of Rheumatology, Immanuel Hospital; I. Koetter, MD, Department of Rheumatology, Asklepios Clinic Altona; A. Kuhn, MD, Division of Immunogenetics, German Cancer Research Center; M. Sticherling, MD, Department of Dermatology, University Hospital Erlangen; M. Hellmich, MD, Institute of Medical Statistics, Informatics and Epidemiology, University of Cologne; K. Kuhr, MD, Institute of Medical Statistics, Informatics and Epidemiology, University of Cologne; T. Krieg, MD, Department of Dermatology, University Hospital of Cologne; J. Ehrchen, MD, Department of Dermatology and Venereology, University Hospital Muenster; C. Sunderkoetter, MD, Department of Dermatology and Venereology, University Hospital Muenster; N. Hunzelmann, MD, Department of Dermatology, University Hospital of Cologne. Address correspondence to Dr. P. Moinzadeh, Department of Dermatology and Venereology, University of Cologne, Kerpener Str. 62, 50937 Cologne, Germany. E-mail: pia.moinzadeh@uk-koeln.de. Accepted for publication August 28, 2015.
Jan Ehrchen
From the Department of Dermatology, University Hospital of Cologne; Department of Internal Medicine, Hospital of Cologne Merheim; Institute of Medical Statistics, Informatics and Epidemiology, University of Cologne, Cologne; Department of Rheumatology, University Medical Center Schleswig-Holstein, Lübeck; Department of Rheumatology and Clinical Immunology, and Department of Dermatology, University of Berlin, Charité, Berlin; Department of Rheumatology, Immanuel Hospital, Berlin-Buch; Department of Dermatology, and Department of Rheumatology, University Hospital Tübingen, Tübingen; Department of Internal Medicine, Division of Rheumatology, Heidelberg University Hospital; Division of Immunogenetics, German Cancer Research Center, Heidelberg; Department of Rheumatology and Clinical Immunology, University Medical Center, Freiburg; Department of Rheumatology and Clinical Immunology, University of Giessen, Kerckhoff Clinic, Bad Nauheim; Department of Dermatology, HELIOS St. Elisabeth Clinic, Oberhausen; Department of Dermatology, St. Joseph Hospital, Ruhr- University of Bochum, Bochum; Department of Dermatology, University Hospital Carl Gustav Carus, Dresden; Department of Rheumatology, Johanniter-Hospital, Treuenbrietzen; Department of Dermatology, Ulm University Hospital, Ulm; Department of Dermatology, University Hospital Regensburg, Regensburg; Department of Rheumatology, Clinic of Rheumatology of Aachen, Aachen; Department of Dermatology, University Hospital Leipzig, Leipzig; Department of Rheumatology, and Department of Dermatology, University Hospital Erlangen, Erlangen; Department of Dermatology, TUM University Hospital; Department of Dermatology, Ludwig Maximilian University, Munich; Department of Rheumatology and Nephrology, University Hospital Duesseldorf, Duesseldorf; Department of Dermatology, University Hospital Göttingen, Göttingen; Department of Dermatology, University Medical Center, Johannes Gutenberg University, Mainz; Clinic for Dermatology, Hamburg Alstertal; Department of Dermatology, Helios Clinic, Wuppertal; Center for Rheumatology Bad Doberan, Bad Doberan; Center for Rheumatology Acura, Baden-Baden; Department of Dermatology, University Hospital of Würzburg, Würzburg; Department of Rheumatology, University Hospital Frankfurt, Frankfurt; Center for Rheumatology (Rehabilitation), Rheinfelden; Clinic for Internal Medicine, Klinikum Stephansplatz; Department of Rheumatology, Asklepios Clinic Altona, Hamburg; Department of Rheumatology, GRP-Hospital Ruesselheim, Darmstadt; Department of Dermatology and Venereology, University Hospital Muenster, Muenster, Germany; Department of Dermatology, Medical University of Graz, Graz, Austria. Supported by a grant of the German Federal Ministry of Education and Research (BMBF; 01GM0310 NH, TK; 01GM0631 CS) and the Edith Busch Foundation. The work of Pia Moinzadeh was supported by “Koeln Fortune” (155/2014) and “Deutsche Stiftung Sklerodermie” (3649/0096/31) grants. P. Moinzadeh, MD, Department of Dermatology, University Hospital of Cologne; G. Riemekasten, MD, Department of Rheumatology, University Medical Center Schleswig-Holstein; E. Siegert, Department of Rheumatology and Clinical Immunology, University of Berlin, Charité; G. Fierlbeck, MD, Department of Dermatology, University Hospital Tübingen; J. Henes, MD, Department of Rheumatology, University Hospital Tübingen; N. Blank, MD, Department of Internal Medicine, Division of Rheumatology, Heidelberg University Hospital; I. Melchers, MD, Department of Rheumatology and Clinical Immunology, University Medical Center; U. Mueller-Ladner, MD, Department of Rheumatology and Clinical Immunology, University of Giessen, Kerckhoff Clinic; M. Frerix, MD, Department of Rheumatology and Clinical Immunology, University of Giessen, Kerckhoff Clinic; A. Kreuter, MD, Department of Dermatology, HELIOS St. Elisabeth Clinic; C. Tigges, MD, Department of Dermatology, HELIOS St. Elisabeth Clinic; N. Lahner, MD, Department of Dermatology, St. Joseph Hospital, Ruhr-University of Bochum; L. Susok, MD, Department of Dermatology, St. Joseph Hospital, Ruhr-University of Bochum; C. Guenther, MD, Department of Dermatology, University Hospital Carl Gustav Carus; G. Zeidler, MD, Department of Rheumatology, Johanniter-Hospital; C. Pfeiffer, MD, Department of Dermatology, Ulm University Hospital; M. Worm, MD, Department of Dermatology, University of Berlin, Charité; S. Karrer, MD, Department of Dermatology, University Hospital Regensburg; E. Aberer, MD, Department of Dermatology, Medical University of Graz; A. Bretterklieber, MD, Department of Dermatology, Medical University of Graz; E. Genth, MD, Department of Rheumatology, Clinic of Rheumatology of Aachen; J.C. Simon, MD, Department of Dermatology, University Hospital Leipzig; J.H. Distler, MD, Department of Rheumatology, University Hospital Erlangen; R. Hein, MD, Department of Dermatology, TUM University Hospital; M. Schneider, MD, Department of Rheumatology and Nephrology, University Hospital Duesseldorf; C.S. Seitz, MD, Department of Dermatology, University Hospital Göttingen; C. Herink, MD, Department of Dermatology, University Hospital Göttingen; K. Steinbrink, MD, Department of Dermatology, University Medical Center, Johannes Gutenberg University; M. Sárdy, MD, Department of Dermatology, Ludwig Maximilian University; R. Varga, MD, Department of Dermatology, Ludwig Maximilian University; H. Mensing, MD, Clinic for Dermatology; C. Mensing, MD, Clinic for Dermatology; P. Lehmann, MD, Department of Dermatology, Helios Clinic; G. Neeck, MD, Center for Rheumatology Bad Doberan; C. Fiehn, MD, Center for Rheumatology Acura; M. Weber, MD, Department of Internal Medicine, Hospital of Cologne Merheim; M. Goebeler, MD, Department of Dermatology, University Hospital of Würzburg; H. Burkhardt, MD, Department of Rheumatology, University Hospital Frankfurt; M. Buslau, MD, Center for Rheumatology (Rehabilitation); K. Ahmadi-Simab, MD, Clinic for Internal Medicine, Klinikum Stephansplatz; A. Himsel, MD, Department of Rheumatology, GRP-Hospital Ruesselheim; A. Juche, MD, Department of Rheumatology, Immanuel Hospital; I. Koetter, MD, Department of Rheumatology, Asklepios Clinic Altona; A. Kuhn, MD, Division of Immunogenetics, German Cancer Research Center; M. Sticherling, MD, Department of Dermatology, University Hospital Erlangen; M. Hellmich, MD, Institute of Medical Statistics, Informatics and Epidemiology, University of Cologne; K. Kuhr, MD, Institute of Medical Statistics, Informatics and Epidemiology, University of Cologne; T. Krieg, MD, Department of Dermatology, University Hospital of Cologne; J. Ehrchen, MD, Department of Dermatology and Venereology, University Hospital Muenster; C. Sunderkoetter, MD, Department of Dermatology and Venereology, University Hospital Muenster; N. Hunzelmann, MD, Department of Dermatology, University Hospital of Cologne. Address correspondence to Dr. P. Moinzadeh, Department of Dermatology and Venereology, University of Cologne, Kerpener Str. 62, 50937 Cologne, Germany. E-mail: pia.moinzadeh@uk-koeln.de. Accepted for publication August 28, 2015.
Cord Sunderkoetter
From the Department of Dermatology, University Hospital of Cologne; Department of Internal Medicine, Hospital of Cologne Merheim; Institute of Medical Statistics, Informatics and Epidemiology, University of Cologne, Cologne; Department of Rheumatology, University Medical Center Schleswig-Holstein, Lübeck; Department of Rheumatology and Clinical Immunology, and Department of Dermatology, University of Berlin, Charité, Berlin; Department of Rheumatology, Immanuel Hospital, Berlin-Buch; Department of Dermatology, and Department of Rheumatology, University Hospital Tübingen, Tübingen; Department of Internal Medicine, Division of Rheumatology, Heidelberg University Hospital; Division of Immunogenetics, German Cancer Research Center, Heidelberg; Department of Rheumatology and Clinical Immunology, University Medical Center, Freiburg; Department of Rheumatology and Clinical Immunology, University of Giessen, Kerckhoff Clinic, Bad Nauheim; Department of Dermatology, HELIOS St. Elisabeth Clinic, Oberhausen; Department of Dermatology, St. Joseph Hospital, Ruhr- University of Bochum, Bochum; Department of Dermatology, University Hospital Carl Gustav Carus, Dresden; Department of Rheumatology, Johanniter-Hospital, Treuenbrietzen; Department of Dermatology, Ulm University Hospital, Ulm; Department of Dermatology, University Hospital Regensburg, Regensburg; Department of Rheumatology, Clinic of Rheumatology of Aachen, Aachen; Department of Dermatology, University Hospital Leipzig, Leipzig; Department of Rheumatology, and Department of Dermatology, University Hospital Erlangen, Erlangen; Department of Dermatology, TUM University Hospital; Department of Dermatology, Ludwig Maximilian University, Munich; Department of Rheumatology and Nephrology, University Hospital Duesseldorf, Duesseldorf; Department of Dermatology, University Hospital Göttingen, Göttingen; Department of Dermatology, University Medical Center, Johannes Gutenberg University, Mainz; Clinic for Dermatology, Hamburg Alstertal; Department of Dermatology, Helios Clinic, Wuppertal; Center for Rheumatology Bad Doberan, Bad Doberan; Center for Rheumatology Acura, Baden-Baden; Department of Dermatology, University Hospital of Würzburg, Würzburg; Department of Rheumatology, University Hospital Frankfurt, Frankfurt; Center for Rheumatology (Rehabilitation), Rheinfelden; Clinic for Internal Medicine, Klinikum Stephansplatz; Department of Rheumatology, Asklepios Clinic Altona, Hamburg; Department of Rheumatology, GRP-Hospital Ruesselheim, Darmstadt; Department of Dermatology and Venereology, University Hospital Muenster, Muenster, Germany; Department of Dermatology, Medical University of Graz, Graz, Austria. Supported by a grant of the German Federal Ministry of Education and Research (BMBF; 01GM0310 NH, TK; 01GM0631 CS) and the Edith Busch Foundation. The work of Pia Moinzadeh was supported by “Koeln Fortune” (155/2014) and “Deutsche Stiftung Sklerodermie” (3649/0096/31) grants. P. Moinzadeh, MD, Department of Dermatology, University Hospital of Cologne; G. Riemekasten, MD, Department of Rheumatology, University Medical Center Schleswig-Holstein; E. Siegert, Department of Rheumatology and Clinical Immunology, University of Berlin, Charité; G. Fierlbeck, MD, Department of Dermatology, University Hospital Tübingen; J. Henes, MD, Department of Rheumatology, University Hospital Tübingen; N. Blank, MD, Department of Internal Medicine, Division of Rheumatology, Heidelberg University Hospital; I. Melchers, MD, Department of Rheumatology and Clinical Immunology, University Medical Center; U. Mueller-Ladner, MD, Department of Rheumatology and Clinical Immunology, University of Giessen, Kerckhoff Clinic; M. Frerix, MD, Department of Rheumatology and Clinical Immunology, University of Giessen, Kerckhoff Clinic; A. Kreuter, MD, Department of Dermatology, HELIOS St. Elisabeth Clinic; C. Tigges, MD, Department of Dermatology, HELIOS St. Elisabeth Clinic; N. Lahner, MD, Department of Dermatology, St. Joseph Hospital, Ruhr-University of Bochum; L. Susok, MD, Department of Dermatology, St. Joseph Hospital, Ruhr-University of Bochum; C. Guenther, MD, Department of Dermatology, University Hospital Carl Gustav Carus; G. Zeidler, MD, Department of Rheumatology, Johanniter-Hospital; C. Pfeiffer, MD, Department of Dermatology, Ulm University Hospital; M. Worm, MD, Department of Dermatology, University of Berlin, Charité; S. Karrer, MD, Department of Dermatology, University Hospital Regensburg; E. Aberer, MD, Department of Dermatology, Medical University of Graz; A. Bretterklieber, MD, Department of Dermatology, Medical University of Graz; E. Genth, MD, Department of Rheumatology, Clinic of Rheumatology of Aachen; J.C. Simon, MD, Department of Dermatology, University Hospital Leipzig; J.H. Distler, MD, Department of Rheumatology, University Hospital Erlangen; R. Hein, MD, Department of Dermatology, TUM University Hospital; M. Schneider, MD, Department of Rheumatology and Nephrology, University Hospital Duesseldorf; C.S. Seitz, MD, Department of Dermatology, University Hospital Göttingen; C. Herink, MD, Department of Dermatology, University Hospital Göttingen; K. Steinbrink, MD, Department of Dermatology, University Medical Center, Johannes Gutenberg University; M. Sárdy, MD, Department of Dermatology, Ludwig Maximilian University; R. Varga, MD, Department of Dermatology, Ludwig Maximilian University; H. Mensing, MD, Clinic for Dermatology; C. Mensing, MD, Clinic for Dermatology; P. Lehmann, MD, Department of Dermatology, Helios Clinic; G. Neeck, MD, Center for Rheumatology Bad Doberan; C. Fiehn, MD, Center for Rheumatology Acura; M. Weber, MD, Department of Internal Medicine, Hospital of Cologne Merheim; M. Goebeler, MD, Department of Dermatology, University Hospital of Würzburg; H. Burkhardt, MD, Department of Rheumatology, University Hospital Frankfurt; M. Buslau, MD, Center for Rheumatology (Rehabilitation); K. Ahmadi-Simab, MD, Clinic for Internal Medicine, Klinikum Stephansplatz; A. Himsel, MD, Department of Rheumatology, GRP-Hospital Ruesselheim; A. Juche, MD, Department of Rheumatology, Immanuel Hospital; I. Koetter, MD, Department of Rheumatology, Asklepios Clinic Altona; A. Kuhn, MD, Division of Immunogenetics, German Cancer Research Center; M. Sticherling, MD, Department of Dermatology, University Hospital Erlangen; M. Hellmich, MD, Institute of Medical Statistics, Informatics and Epidemiology, University of Cologne; K. Kuhr, MD, Institute of Medical Statistics, Informatics and Epidemiology, University of Cologne; T. Krieg, MD, Department of Dermatology, University Hospital of Cologne; J. Ehrchen, MD, Department of Dermatology and Venereology, University Hospital Muenster; C. Sunderkoetter, MD, Department of Dermatology and Venereology, University Hospital Muenster; N. Hunzelmann, MD, Department of Dermatology, University Hospital of Cologne. Address correspondence to Dr. P. Moinzadeh, Department of Dermatology and Venereology, University of Cologne, Kerpener Str. 62, 50937 Cologne, Germany. E-mail: pia.moinzadeh@uk-koeln.de. Accepted for publication August 28, 2015.
Nicolas Hunzelmann
From the Department of Dermatology, University Hospital of Cologne; Department of Internal Medicine, Hospital of Cologne Merheim; Institute of Medical Statistics, Informatics and Epidemiology, University of Cologne, Cologne; Department of Rheumatology, University Medical Center Schleswig-Holstein, Lübeck; Department of Rheumatology and Clinical Immunology, and Department of Dermatology, University of Berlin, Charité, Berlin; Department of Rheumatology, Immanuel Hospital, Berlin-Buch; Department of Dermatology, and Department of Rheumatology, University Hospital Tübingen, Tübingen; Department of Internal Medicine, Division of Rheumatology, Heidelberg University Hospital; Division of Immunogenetics, German Cancer Research Center, Heidelberg; Department of Rheumatology and Clinical Immunology, University Medical Center, Freiburg; Department of Rheumatology and Clinical Immunology, University of Giessen, Kerckhoff Clinic, Bad Nauheim; Department of Dermatology, HELIOS St. Elisabeth Clinic, Oberhausen; Department of Dermatology, St. Joseph Hospital, Ruhr- University of Bochum, Bochum; Department of Dermatology, University Hospital Carl Gustav Carus, Dresden; Department of Rheumatology, Johanniter-Hospital, Treuenbrietzen; Department of Dermatology, Ulm University Hospital, Ulm; Department of Dermatology, University Hospital Regensburg, Regensburg; Department of Rheumatology, Clinic of Rheumatology of Aachen, Aachen; Department of Dermatology, University Hospital Leipzig, Leipzig; Department of Rheumatology, and Department of Dermatology, University Hospital Erlangen, Erlangen; Department of Dermatology, TUM University Hospital; Department of Dermatology, Ludwig Maximilian University, Munich; Department of Rheumatology and Nephrology, University Hospital Duesseldorf, Duesseldorf; Department of Dermatology, University Hospital Göttingen, Göttingen; Department of Dermatology, University Medical Center, Johannes Gutenberg University, Mainz; Clinic for Dermatology, Hamburg Alstertal; Department of Dermatology, Helios Clinic, Wuppertal; Center for Rheumatology Bad Doberan, Bad Doberan; Center for Rheumatology Acura, Baden-Baden; Department of Dermatology, University Hospital of Würzburg, Würzburg; Department of Rheumatology, University Hospital Frankfurt, Frankfurt; Center for Rheumatology (Rehabilitation), Rheinfelden; Clinic for Internal Medicine, Klinikum Stephansplatz; Department of Rheumatology, Asklepios Clinic Altona, Hamburg; Department of Rheumatology, GRP-Hospital Ruesselheim, Darmstadt; Department of Dermatology and Venereology, University Hospital Muenster, Muenster, Germany; Department of Dermatology, Medical University of Graz, Graz, Austria. Supported by a grant of the German Federal Ministry of Education and Research (BMBF; 01GM0310 NH, TK; 01GM0631 CS) and the Edith Busch Foundation. The work of Pia Moinzadeh was supported by “Koeln Fortune” (155/2014) and “Deutsche Stiftung Sklerodermie” (3649/0096/31) grants. P. Moinzadeh, MD, Department of Dermatology, University Hospital of Cologne; G. Riemekasten, MD, Department of Rheumatology, University Medical Center Schleswig-Holstein; E. Siegert, Department of Rheumatology and Clinical Immunology, University of Berlin, Charité; G. Fierlbeck, MD, Department of Dermatology, University Hospital Tübingen; J. Henes, MD, Department of Rheumatology, University Hospital Tübingen; N. Blank, MD, Department of Internal Medicine, Division of Rheumatology, Heidelberg University Hospital; I. Melchers, MD, Department of Rheumatology and Clinical Immunology, University Medical Center; U. Mueller-Ladner, MD, Department of Rheumatology and Clinical Immunology, University of Giessen, Kerckhoff Clinic; M. Frerix, MD, Department of Rheumatology and Clinical Immunology, University of Giessen, Kerckhoff Clinic; A. Kreuter, MD, Department of Dermatology, HELIOS St. Elisabeth Clinic; C. Tigges, MD, Department of Dermatology, HELIOS St. Elisabeth Clinic; N. Lahner, MD, Department of Dermatology, St. Joseph Hospital, Ruhr-University of Bochum; L. Susok, MD, Department of Dermatology, St. Joseph Hospital, Ruhr-University of Bochum; C. Guenther, MD, Department of Dermatology, University Hospital Carl Gustav Carus; G. Zeidler, MD, Department of Rheumatology, Johanniter-Hospital; C. Pfeiffer, MD, Department of Dermatology, Ulm University Hospital; M. Worm, MD, Department of Dermatology, University of Berlin, Charité; S. Karrer, MD, Department of Dermatology, University Hospital Regensburg; E. Aberer, MD, Department of Dermatology, Medical University of Graz; A. Bretterklieber, MD, Department of Dermatology, Medical University of Graz; E. Genth, MD, Department of Rheumatology, Clinic of Rheumatology of Aachen; J.C. Simon, MD, Department of Dermatology, University Hospital Leipzig; J.H. Distler, MD, Department of Rheumatology, University Hospital Erlangen; R. Hein, MD, Department of Dermatology, TUM University Hospital; M. Schneider, MD, Department of Rheumatology and Nephrology, University Hospital Duesseldorf; C.S. Seitz, MD, Department of Dermatology, University Hospital Göttingen; C. Herink, MD, Department of Dermatology, University Hospital Göttingen; K. Steinbrink, MD, Department of Dermatology, University Medical Center, Johannes Gutenberg University; M. Sárdy, MD, Department of Dermatology, Ludwig Maximilian University; R. Varga, MD, Department of Dermatology, Ludwig Maximilian University; H. Mensing, MD, Clinic for Dermatology; C. Mensing, MD, Clinic for Dermatology; P. Lehmann, MD, Department of Dermatology, Helios Clinic; G. Neeck, MD, Center for Rheumatology Bad Doberan; C. Fiehn, MD, Center for Rheumatology Acura; M. Weber, MD, Department of Internal Medicine, Hospital of Cologne Merheim; M. Goebeler, MD, Department of Dermatology, University Hospital of Würzburg; H. Burkhardt, MD, Department of Rheumatology, University Hospital Frankfurt; M. Buslau, MD, Center for Rheumatology (Rehabilitation); K. Ahmadi-Simab, MD, Clinic for Internal Medicine, Klinikum Stephansplatz; A. Himsel, MD, Department of Rheumatology, GRP-Hospital Ruesselheim; A. Juche, MD, Department of Rheumatology, Immanuel Hospital; I. Koetter, MD, Department of Rheumatology, Asklepios Clinic Altona; A. Kuhn, MD, Division of Immunogenetics, German Cancer Research Center; M. Sticherling, MD, Department of Dermatology, University Hospital Erlangen; M. Hellmich, MD, Institute of Medical Statistics, Informatics and Epidemiology, University of Cologne; K. Kuhr, MD, Institute of Medical Statistics, Informatics and Epidemiology, University of Cologne; T. Krieg, MD, Department of Dermatology, University Hospital of Cologne; J. Ehrchen, MD, Department of Dermatology and Venereology, University Hospital Muenster; C. Sunderkoetter, MD, Department of Dermatology and Venereology, University Hospital Muenster; N. Hunzelmann, MD, Department of Dermatology, University Hospital of Cologne. Address correspondence to Dr. P. Moinzadeh, Department of Dermatology and Venereology, University of Cologne, Kerpener Str. 62, 50937 Cologne, Germany. E-mail: pia.moinzadeh@uk-koeln.de. Accepted for publication August 28, 2015.
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- Published online November 15, 2015.
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- Pia Moinzadeh,
- Gabriela Riemekasten,
- Elise Siegert,
- Gerhard Fierlbeck,
- Joerg Henes,
- Norbert Blank,
- Inga Melchers,
- Ulf Mueller-Ladner,
- Marc Frerix,
- Alexander Kreuter,
- Christian Tigges,
- Nina Lahner,
- Laura Susok,
- Claudia Guenther,
- Gabriele Zeidler,
- Christiane Pfeiffer,
- Margitta Worm,
- Sigrid Karrer,
- Elisabeth Aberer,
- Agnes Bretterklieber,
- Ekkehard Genth,
- Jan C. Simon,
- Joerg H.W. Distler,
- Ruediger Hein,
- Matthias Schneider,
- Cornelia S. Seitz,
- Claudia Herink,
- Kerstin Steinbrink,
- Miklos Sárdy,
- Rita Varga,
- Hartwig Mensing,
- Christian Mensing,
- Percy Lehmann,
- Gunther Neeck,
- Christoph Fiehn,
- Manfred Weber,
- Matthias Goebeler,
- Harald Burkhardt,
- Michael Buslau,
- Keihan Ahmadi-Simab,
- Andrea Himsel,
- Aaron Juche,
- Ina Koetter,
- Annegret Kuhn,
- Michael Sticherling,
- Martin Hellmich,
- Kathrin Kuhr,
- Thomas Krieg,
- Jan Ehrchen,
- Cord Sunderkoetter and
- Nicolas Hunzelmann, for the German Network for Systemic Scleroderma
- From the Department of Dermatology, University Hospital of Cologne; Department of Internal Medicine, Hospital of Cologne Merheim; Institute of Medical Statistics, Informatics and Epidemiology, University of Cologne, Cologne; Department of Rheumatology, University Medical Center Schleswig-Holstein, Lübeck; Department of Rheumatology and Clinical Immunology, and Department of Dermatology, University of Berlin, Charité, Berlin; Department of Rheumatology, Immanuel Hospital, Berlin-Buch; Department of Dermatology, and Department of Rheumatology, University Hospital Tübingen, Tübingen; Department of Internal Medicine, Division of Rheumatology, Heidelberg University Hospital; Division of Immunogenetics, German Cancer Research Center, Heidelberg; Department of Rheumatology and Clinical Immunology, University Medical Center, Freiburg; Department of Rheumatology and Clinical Immunology, University of Giessen, Kerckhoff Clinic, Bad Nauheim; Department of Dermatology, HELIOS St. Elisabeth Clinic, Oberhausen; Department of Dermatology, St. Joseph Hospital, Ruhr- University of Bochum, Bochum; Department of Dermatology, University Hospital Carl Gustav Carus, Dresden; Department of Rheumatology, Johanniter-Hospital, Treuenbrietzen; Department of Dermatology, Ulm University Hospital, Ulm; Department of Dermatology, University Hospital Regensburg, Regensburg; Department of Rheumatology, Clinic of Rheumatology of Aachen, Aachen; Department of Dermatology, University Hospital Leipzig, Leipzig; Department of Rheumatology, and Department of Dermatology, University Hospital Erlangen, Erlangen; Department of Dermatology, TUM University Hospital; Department of Dermatology, Ludwig Maximilian University, Munich; Department of Rheumatology and Nephrology, University Hospital Duesseldorf, Duesseldorf; Department of Dermatology, University Hospital Göttingen, Göttingen; Department of Dermatology, University Medical Center, Johannes Gutenberg University, Mainz; Clinic for Dermatology, Hamburg Alstertal; Department of Dermatology, Helios Clinic, Wuppertal; Center for Rheumatology Bad Doberan, Bad Doberan; Center for Rheumatology Acura, Baden-Baden; Department of Dermatology, University Hospital of Würzburg, Würzburg; Department of Rheumatology, University Hospital Frankfurt, Frankfurt; Center for Rheumatology (Rehabilitation), Rheinfelden; Clinic for Internal Medicine, Klinikum Stephansplatz; Department of Rheumatology, Asklepios Clinic Altona, Hamburg; Department of Rheumatology, GRP-Hospital Ruesselheim, Darmstadt; Department of Dermatology and Venereology, University Hospital Muenster, Muenster, Germany; Department of Dermatology, Medical University of Graz, Graz, Austria.
Supported by a grant of the German Federal Ministry of Education and Research (BMBF; 01GM0310 NH, TK; 01GM0631 CS) and the Edith Busch Foundation. The work of Pia Moinzadeh was supported by “Koeln Fortune” (155/2014) and “Deutsche Stiftung Sklerodermie” (3649/0096/31) grants.
P. Moinzadeh, MD, Department of Dermatology, University Hospital of Cologne; G. Riemekasten, MD, Department of Rheumatology, University Medical Center Schleswig-Holstein; E. Siegert, Department of Rheumatology and Clinical Immunology, University of Berlin, Charité; G. Fierlbeck, MD, Department of Dermatology, University Hospital Tübingen; J. Henes, MD, Department of Rheumatology, University Hospital Tübingen; N. Blank, MD, Department of Internal Medicine, Division of Rheumatology, Heidelberg University Hospital; I. Melchers, MD, Department of Rheumatology and Clinical Immunology, University Medical Center; U. Mueller-Ladner, MD, Department of Rheumatology and Clinical Immunology, University of Giessen, Kerckhoff Clinic; M. Frerix, MD, Department of Rheumatology and Clinical Immunology, University of Giessen, Kerckhoff Clinic; A. Kreuter, MD, Department of Dermatology, HELIOS St. Elisabeth Clinic; C. Tigges, MD, Department of Dermatology, HELIOS St. Elisabeth Clinic; N. Lahner, MD, Department of Dermatology, St. Joseph Hospital, Ruhr-University of Bochum; L. Susok, MD, Department of Dermatology, St. Joseph Hospital, Ruhr-University of Bochum; C. Guenther, MD, Department of Dermatology, University Hospital Carl Gustav Carus; G. Zeidler, MD, Department of Rheumatology, Johanniter-Hospital; C. Pfeiffer, MD, Department of Dermatology, Ulm University Hospital; M. Worm, MD, Department of Dermatology, University of Berlin, Charité; S. Karrer, MD, Department of Dermatology, University Hospital Regensburg; E. Aberer, MD, Department of Dermatology, Medical University of Graz; A. Bretterklieber, MD, Department of Dermatology, Medical University of Graz; E. Genth, MD, Department of Rheumatology, Clinic of Rheumatology of Aachen; J.C. Simon, MD, Department of Dermatology, University Hospital Leipzig; J.H. Distler, MD, Department of Rheumatology, University Hospital Erlangen; R. Hein, MD, Department of Dermatology, TUM University Hospital; M. Schneider, MD, Department of Rheumatology and Nephrology, University Hospital Duesseldorf; C.S. Seitz, MD, Department of Dermatology, University Hospital Göttingen; C. Herink, MD, Department of Dermatology, University Hospital Göttingen; K. Steinbrink, MD, Department of Dermatology, University Medical Center, Johannes Gutenberg University; M. Sárdy, MD, Department of Dermatology, Ludwig Maximilian University; R. Varga, MD, Department of Dermatology, Ludwig Maximilian University; H. Mensing, MD, Clinic for Dermatology; C. Mensing, MD, Clinic for Dermatology; P. Lehmann, MD, Department of Dermatology, Helios Clinic; G. Neeck, MD, Center for Rheumatology Bad Doberan; C. Fiehn, MD, Center for Rheumatology Acura; M. Weber, MD, Department of Internal Medicine, Hospital of Cologne Merheim; M. Goebeler, MD, Department of Dermatology, University Hospital of Würzburg; H. Burkhardt, MD, Department of Rheumatology, University Hospital Frankfurt; M. Buslau, MD, Center for Rheumatology (Rehabilitation); K. Ahmadi-Simab, MD, Clinic for Internal Medicine, Klinikum Stephansplatz; A. Himsel, MD, Department of Rheumatology, GRP-Hospital Ruesselheim; A. Juche, MD, Department of Rheumatology, Immanuel Hospital; I. Koetter, MD, Department of Rheumatology, Asklepios Clinic Altona; A. Kuhn, MD, Division of Immunogenetics, German Cancer Research Center; M. Sticherling, MD, Department of Dermatology, University Hospital Erlangen; M. Hellmich, MD, Institute of Medical Statistics, Informatics and Epidemiology, University of Cologne; K. Kuhr, MD, Institute of Medical Statistics, Informatics and Epidemiology, University of Cologne; T. Krieg, MD, Department of Dermatology, University Hospital of Cologne; J. Ehrchen, MD, Department of Dermatology and Venereology, University Hospital Muenster; C. Sunderkoetter, MD, Department of Dermatology and Venereology, University Hospital Muenster; N. Hunzelmann, MD, Department of Dermatology, University Hospital of Cologne.
Address correspondence to Dr. P. Moinzadeh, Department of Dermatology and Venereology, University of Cologne, Kerpener Str. 62, 50937 Cologne, Germany. E-mail: pia.moinzadeh@uk-koeln.de.
Accepted for publication August 28, 2015.
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The Journal of Rheumatology
Vol. 51, Issue 4
1 Apr 2024
Vasoactive Therapy in Systemic Sclerosis: Real-life Therapeutic Practice in More Than 3000 Patients
Pia Moinzadeh, Gabriela Riemekasten, Elise Siegert, Gerhard Fierlbeck, Joerg Henes, Norbert Blank, Inga Melchers, Ulf Mueller-Ladner, Marc Frerix, Alexander Kreuter, Christian Tigges, Nina Lahner, Laura Susok, Claudia Guenther, Gabriele Zeidler, Christiane Pfeiffer, Margitta Worm, Sigrid Karrer, Elisabeth Aberer, Agnes Bretterklieber, Ekkehard Genth, Jan C. Simon, Joerg H.W. Distler, Ruediger Hein, Matthias Schneider, Cornelia S. Seitz, Claudia Herink, Kerstin Steinbrink, Miklos Sárdy, Rita Varga, Hartwig Mensing, Christian Mensing, Percy Lehmann, Gunther Neeck, Christoph Fiehn, Manfred Weber, Matthias Goebeler, Harald Burkhardt, Michael Buslau, Keihan Ahmadi-Simab, Andrea Himsel, Aaron Juche, Ina Koetter, Annegret Kuhn, Michael Sticherling, Martin Hellmich, Kathrin Kuhr, Thomas Krieg, Jan Ehrchen, Cord Sunderkoetter, Nicolas Hunzelmann
The Journal of Rheumatology Nov 2015, jrheum.150382; DOI: 10.3899/jrheum.150382
Vasoactive Therapy in Systemic Sclerosis: Real-life Therapeutic Practice in More Than 3000 Patients
Pia Moinzadeh, Gabriela Riemekasten, Elise Siegert, Gerhard Fierlbeck, Joerg Henes, Norbert Blank, Inga Melchers, Ulf Mueller-Ladner, Marc Frerix, Alexander Kreuter, Christian Tigges, Nina Lahner, Laura Susok, Claudia Guenther, Gabriele Zeidler, Christiane Pfeiffer, Margitta Worm, Sigrid Karrer, Elisabeth Aberer, Agnes Bretterklieber, Ekkehard Genth, Jan C. Simon, Joerg H.W. Distler, Ruediger Hein, Matthias Schneider, Cornelia S. Seitz, Claudia Herink, Kerstin Steinbrink, Miklos Sárdy, Rita Varga, Hartwig Mensing, Christian Mensing, Percy Lehmann, Gunther Neeck, Christoph Fiehn, Manfred Weber, Matthias Goebeler, Harald Burkhardt, Michael Buslau, Keihan Ahmadi-Simab, Andrea Himsel, Aaron Juche, Ina Koetter, Annegret Kuhn, Michael Sticherling, Martin Hellmich, Kathrin Kuhr, Thomas Krieg, Jan Ehrchen, Cord Sunderkoetter, Nicolas Hunzelmann
The Journal of Rheumatology Nov 2015, jrheum.150382; DOI: 10.3899/jrheum.150382