Research ArticleArticle
Performance of Different Diagnostic Criteria for Familial Mediterranean Fever in Children with Periodic Fevers: Results from a Multicenter International Registry
Erkan Demirkaya, Celal Saglam, Turker Turker, Isabelle Koné-Paut, Pat Woo, Matteo Doglio, Gayane Amaryan, Joost Frenkel, Yosef Uziel, Antonella Insalaco, Luca Cantarini, Michael Hofer, Sorina Boiu, Ali Duzova, Consuelo Modesto, Annette Bryant, Donato Rigante, Efimia Papadopoulou-Alataki, Severine Guillaume-Czitrom, Jasmine Kuemmerle-Deschner, Bénédicte Neven, Helen Lachmann, Alberto Martini, Nicolino Ruperto, Marco Gattorno and Seza Ozen
The Journal of Rheumatology November 2015, jrheum.141249; DOI: https://doi.org/10.3899/jrheum.141249
Erkan Demirkaya
From the Familial Mediterranean Fever Arthritis Vasculitis and Orphan Disease Research Center (FAVOR), Gulhane Military Medical Faculty; Epidemiology, Gulhane Military Medical Faculty, Ankara, Turkey; Centre de référence national des maladies auto-inflammatoires, CEREMAI, Rhumatologie pédiatrique, CHU Le Kremlin Bicêtre (APHP, University of Paris SUD), Paris, France; Center of Paediatric and Adolescent Rheumatology, UCL, London, UK; Istituto Giannina Gaslini, UO Pediatria II, Reumatologia, Genoa, Italy; Arabkir Medical Centre, Institute of Child and Adolescents Health, Yerevan, Armenia; Department of Paediatrics, University Medical Center Utrecht, Utrecht, Netherlands; Pediatrics, Meir Medical Centre, Kfar Saba, Israel; Division of Rheumatology, Department of Pediatric Medicine, Bambino Gesù Children’s Hospital, IRCCS, Rome; Rheumatology Unit, Policlinico le Scotte, University of Siena, Siena, Italy; Pediatrie, Centre Multisite Romand de Rhumatologie Pediatrique/Centre Hospitalier, Universitaire Vaudois (CHUV), Lausanne, Switzerland; Pediatric Rheumatology, Université Paris-Descartes, Paris, France; Pediatric Rheumatology, Hacettepe University, School of Medicine, Ankara, Turkey; Reumatologia, Hospital Valle de Hebron, Barcelona, Spain; Pediatrics, Università Cattolica Sacro Cuore, Rome, Italy; Fourth Department of Pediatrics, Aristotle University of Thessaloniki Papageorgiou Hospital, Thessaloniki, Greece; Universitatsklinik fur Kinderheilkunde und Jugendmedizin, Tübingen, Germany; Université Paris-Descartes, Hôpital Necker-Enfants Malades, Centre de référence national pour les Arthrites Juveniles, Unité d’Immunologie, Hématologie et Rhumatologie Pédiatrique, Université Descartes, Sorbonne Paris Cité, Institut IMAGINE, Paris, France; National Amyloidosis Centre, University College London Medical School, Royal Free Campus, London, UK. The Eurofever registry was sponsored by the Autoinflammatory Diseases’ Working Group of the Paediatric Rheumatology European Society and supported by the Executive Agency For Health and Consumers (Project No 2007332) and by Coordination Theme 1 (Health) of the European Community’s FP7 (Eurotraps, grant agreement no. HEALTH-F2-2008-200923). Novartis and SOBI have granted unrestricted educational grants. E. Demirkaya, MD, MSc, FAVOR, Gulhane Military Medical Faculty; C. Saglam, MD, FAVOR, Gulhane Military Medical Faculty; T. Turker, MD, Epidemiology, Gulhane Military Medical Faculty; I. Koné-Paut, MD, CEREMAI, Rhumatologie pédiatrique, CHU Le Kremlin Bicêtre (APHP, University of Paris SUD); P. Woo, MD, Center of Paediatric and Adolescent Rheumatology, UCL; M. Doglio, MD, Istituto Giannina Gaslini, UO Pediatria II, Reumatologia; G. Amaryan, MD, PhD, Arabkir Medical Centre, Institute of Child and Adolescents Health; J. Frenkel, MD, Department of Paediatrics, University Medical Center Utrecht; Y. Uziel, MD, MSc, Pediatrics, Meir Medical Centre; A. Insalaco, MD, Division of Rheumatology, Department of Pediatric Medicine, Bambino Gesù Children’s Hospital, IRCCS; L. Cantarini, MD, Rheumatology Unit, Policlinico le Scotte, University of Siena; M. Hofer, MD, PhD, Pediatrie, Centre Multisite Romand de Rhumatologie Pediatrique/CHUV; S. Boiu, MD, Pediatric Rheumatology, Université Paris-Descartes; A. Duzova, MD, Pediatric Rheumatology, Hacettepe University, School of Medicine; C. Modesto, MD, PhD, Reumatologia, Hospital Valle de Hebron; A. Bryant, MD, Center of Paediatric and Adolescent Rheumatology, UCL; D. Rigante, MD, Pediatrics, Università Cattolica Sacro Cuore; E. Papadopoulou-Alataki, MD, PhD, Fourth Department of Pediatrics, Aristotle University of Thessaloniki Papageorgiou Hospital; S. Guillaume-Czitrom, MD, CEREMAI, Rhumatologie pédiatrique, CHU Le Kremlin Bicêtre (APHP, University of Paris SUD); J. Kuemmerle-Deschner, MD, Universitatsklinik fur Kinderheilkunde und Jugendmedizin; B. Neven, MD, Université Paris-Descartes, Hôpital Necker-Enfants Malades, Centre de référence national pour les Arthrites Juveniles, Unité d’Immunologie, Hématologie et Rhumatologie Pédiatrique, Université Descartes, Sorbonne Paris Cité, Institut IMAGINE; H. Lachmann, MD, National Amyloidosis Centre, University College London Medical School, Royal Free Campus; A. Martini, MD, Professor, Istituto Giannina Gaslini, UO Pediatria II, Reumatologia; N. Ruperto, MD, MPH, Istituto Giannina Gaslini, UO Pediatria II, Reumatologia; M. Gattorno, MD, Istituto Giannina Gaslini, UO Pediatria II, Reumatologia; S. Ozen, MD, Pediatric Rheumatology, Hacettepe University, School of Medicine. Dr. Gattorno and Dr. Ozen contributed equally to this manuscript. Address correspondence to Dr. M. Gattorno, UO pediatria II, Istituto G. Gaslini, Largo G. Gaslini 5, 16147, Genoa, Italy. E-mail: marcogattorno@ospedale-gaslini.ge.it. Accepted for publication August 14, 2015.
Celal Saglam
From the Familial Mediterranean Fever Arthritis Vasculitis and Orphan Disease Research Center (FAVOR), Gulhane Military Medical Faculty; Epidemiology, Gulhane Military Medical Faculty, Ankara, Turkey; Centre de référence national des maladies auto-inflammatoires, CEREMAI, Rhumatologie pédiatrique, CHU Le Kremlin Bicêtre (APHP, University of Paris SUD), Paris, France; Center of Paediatric and Adolescent Rheumatology, UCL, London, UK; Istituto Giannina Gaslini, UO Pediatria II, Reumatologia, Genoa, Italy; Arabkir Medical Centre, Institute of Child and Adolescents Health, Yerevan, Armenia; Department of Paediatrics, University Medical Center Utrecht, Utrecht, Netherlands; Pediatrics, Meir Medical Centre, Kfar Saba, Israel; Division of Rheumatology, Department of Pediatric Medicine, Bambino Gesù Children’s Hospital, IRCCS, Rome; Rheumatology Unit, Policlinico le Scotte, University of Siena, Siena, Italy; Pediatrie, Centre Multisite Romand de Rhumatologie Pediatrique/Centre Hospitalier, Universitaire Vaudois (CHUV), Lausanne, Switzerland; Pediatric Rheumatology, Université Paris-Descartes, Paris, France; Pediatric Rheumatology, Hacettepe University, School of Medicine, Ankara, Turkey; Reumatologia, Hospital Valle de Hebron, Barcelona, Spain; Pediatrics, Università Cattolica Sacro Cuore, Rome, Italy; Fourth Department of Pediatrics, Aristotle University of Thessaloniki Papageorgiou Hospital, Thessaloniki, Greece; Universitatsklinik fur Kinderheilkunde und Jugendmedizin, Tübingen, Germany; Université Paris-Descartes, Hôpital Necker-Enfants Malades, Centre de référence national pour les Arthrites Juveniles, Unité d’Immunologie, Hématologie et Rhumatologie Pédiatrique, Université Descartes, Sorbonne Paris Cité, Institut IMAGINE, Paris, France; National Amyloidosis Centre, University College London Medical School, Royal Free Campus, London, UK. The Eurofever registry was sponsored by the Autoinflammatory Diseases’ Working Group of the Paediatric Rheumatology European Society and supported by the Executive Agency For Health and Consumers (Project No 2007332) and by Coordination Theme 1 (Health) of the European Community’s FP7 (Eurotraps, grant agreement no. HEALTH-F2-2008-200923). Novartis and SOBI have granted unrestricted educational grants. E. Demirkaya, MD, MSc, FAVOR, Gulhane Military Medical Faculty; C. Saglam, MD, FAVOR, Gulhane Military Medical Faculty; T. Turker, MD, Epidemiology, Gulhane Military Medical Faculty; I. Koné-Paut, MD, CEREMAI, Rhumatologie pédiatrique, CHU Le Kremlin Bicêtre (APHP, University of Paris SUD); P. Woo, MD, Center of Paediatric and Adolescent Rheumatology, UCL; M. Doglio, MD, Istituto Giannina Gaslini, UO Pediatria II, Reumatologia; G. Amaryan, MD, PhD, Arabkir Medical Centre, Institute of Child and Adolescents Health; J. Frenkel, MD, Department of Paediatrics, University Medical Center Utrecht; Y. Uziel, MD, MSc, Pediatrics, Meir Medical Centre; A. Insalaco, MD, Division of Rheumatology, Department of Pediatric Medicine, Bambino Gesù Children’s Hospital, IRCCS; L. Cantarini, MD, Rheumatology Unit, Policlinico le Scotte, University of Siena; M. Hofer, MD, PhD, Pediatrie, Centre Multisite Romand de Rhumatologie Pediatrique/CHUV; S. Boiu, MD, Pediatric Rheumatology, Université Paris-Descartes; A. Duzova, MD, Pediatric Rheumatology, Hacettepe University, School of Medicine; C. Modesto, MD, PhD, Reumatologia, Hospital Valle de Hebron; A. Bryant, MD, Center of Paediatric and Adolescent Rheumatology, UCL; D. Rigante, MD, Pediatrics, Università Cattolica Sacro Cuore; E. Papadopoulou-Alataki, MD, PhD, Fourth Department of Pediatrics, Aristotle University of Thessaloniki Papageorgiou Hospital; S. Guillaume-Czitrom, MD, CEREMAI, Rhumatologie pédiatrique, CHU Le Kremlin Bicêtre (APHP, University of Paris SUD); J. Kuemmerle-Deschner, MD, Universitatsklinik fur Kinderheilkunde und Jugendmedizin; B. Neven, MD, Université Paris-Descartes, Hôpital Necker-Enfants Malades, Centre de référence national pour les Arthrites Juveniles, Unité d’Immunologie, Hématologie et Rhumatologie Pédiatrique, Université Descartes, Sorbonne Paris Cité, Institut IMAGINE; H. Lachmann, MD, National Amyloidosis Centre, University College London Medical School, Royal Free Campus; A. Martini, MD, Professor, Istituto Giannina Gaslini, UO Pediatria II, Reumatologia; N. Ruperto, MD, MPH, Istituto Giannina Gaslini, UO Pediatria II, Reumatologia; M. Gattorno, MD, Istituto Giannina Gaslini, UO Pediatria II, Reumatologia; S. Ozen, MD, Pediatric Rheumatology, Hacettepe University, School of Medicine. Dr. Gattorno and Dr. Ozen contributed equally to this manuscript. Address correspondence to Dr. M. Gattorno, UO pediatria II, Istituto G. Gaslini, Largo G. Gaslini 5, 16147, Genoa, Italy. E-mail: marcogattorno@ospedale-gaslini.ge.it. Accepted for publication August 14, 2015.
Turker Turker
From the Familial Mediterranean Fever Arthritis Vasculitis and Orphan Disease Research Center (FAVOR), Gulhane Military Medical Faculty; Epidemiology, Gulhane Military Medical Faculty, Ankara, Turkey; Centre de référence national des maladies auto-inflammatoires, CEREMAI, Rhumatologie pédiatrique, CHU Le Kremlin Bicêtre (APHP, University of Paris SUD), Paris, France; Center of Paediatric and Adolescent Rheumatology, UCL, London, UK; Istituto Giannina Gaslini, UO Pediatria II, Reumatologia, Genoa, Italy; Arabkir Medical Centre, Institute of Child and Adolescents Health, Yerevan, Armenia; Department of Paediatrics, University Medical Center Utrecht, Utrecht, Netherlands; Pediatrics, Meir Medical Centre, Kfar Saba, Israel; Division of Rheumatology, Department of Pediatric Medicine, Bambino Gesù Children’s Hospital, IRCCS, Rome; Rheumatology Unit, Policlinico le Scotte, University of Siena, Siena, Italy; Pediatrie, Centre Multisite Romand de Rhumatologie Pediatrique/Centre Hospitalier, Universitaire Vaudois (CHUV), Lausanne, Switzerland; Pediatric Rheumatology, Université Paris-Descartes, Paris, France; Pediatric Rheumatology, Hacettepe University, School of Medicine, Ankara, Turkey; Reumatologia, Hospital Valle de Hebron, Barcelona, Spain; Pediatrics, Università Cattolica Sacro Cuore, Rome, Italy; Fourth Department of Pediatrics, Aristotle University of Thessaloniki Papageorgiou Hospital, Thessaloniki, Greece; Universitatsklinik fur Kinderheilkunde und Jugendmedizin, Tübingen, Germany; Université Paris-Descartes, Hôpital Necker-Enfants Malades, Centre de référence national pour les Arthrites Juveniles, Unité d’Immunologie, Hématologie et Rhumatologie Pédiatrique, Université Descartes, Sorbonne Paris Cité, Institut IMAGINE, Paris, France; National Amyloidosis Centre, University College London Medical School, Royal Free Campus, London, UK. The Eurofever registry was sponsored by the Autoinflammatory Diseases’ Working Group of the Paediatric Rheumatology European Society and supported by the Executive Agency For Health and Consumers (Project No 2007332) and by Coordination Theme 1 (Health) of the European Community’s FP7 (Eurotraps, grant agreement no. HEALTH-F2-2008-200923). Novartis and SOBI have granted unrestricted educational grants. E. Demirkaya, MD, MSc, FAVOR, Gulhane Military Medical Faculty; C. Saglam, MD, FAVOR, Gulhane Military Medical Faculty; T. Turker, MD, Epidemiology, Gulhane Military Medical Faculty; I. Koné-Paut, MD, CEREMAI, Rhumatologie pédiatrique, CHU Le Kremlin Bicêtre (APHP, University of Paris SUD); P. Woo, MD, Center of Paediatric and Adolescent Rheumatology, UCL; M. Doglio, MD, Istituto Giannina Gaslini, UO Pediatria II, Reumatologia; G. Amaryan, MD, PhD, Arabkir Medical Centre, Institute of Child and Adolescents Health; J. Frenkel, MD, Department of Paediatrics, University Medical Center Utrecht; Y. Uziel, MD, MSc, Pediatrics, Meir Medical Centre; A. Insalaco, MD, Division of Rheumatology, Department of Pediatric Medicine, Bambino Gesù Children’s Hospital, IRCCS; L. Cantarini, MD, Rheumatology Unit, Policlinico le Scotte, University of Siena; M. Hofer, MD, PhD, Pediatrie, Centre Multisite Romand de Rhumatologie Pediatrique/CHUV; S. Boiu, MD, Pediatric Rheumatology, Université Paris-Descartes; A. Duzova, MD, Pediatric Rheumatology, Hacettepe University, School of Medicine; C. Modesto, MD, PhD, Reumatologia, Hospital Valle de Hebron; A. Bryant, MD, Center of Paediatric and Adolescent Rheumatology, UCL; D. Rigante, MD, Pediatrics, Università Cattolica Sacro Cuore; E. Papadopoulou-Alataki, MD, PhD, Fourth Department of Pediatrics, Aristotle University of Thessaloniki Papageorgiou Hospital; S. Guillaume-Czitrom, MD, CEREMAI, Rhumatologie pédiatrique, CHU Le Kremlin Bicêtre (APHP, University of Paris SUD); J. Kuemmerle-Deschner, MD, Universitatsklinik fur Kinderheilkunde und Jugendmedizin; B. Neven, MD, Université Paris-Descartes, Hôpital Necker-Enfants Malades, Centre de référence national pour les Arthrites Juveniles, Unité d’Immunologie, Hématologie et Rhumatologie Pédiatrique, Université Descartes, Sorbonne Paris Cité, Institut IMAGINE; H. Lachmann, MD, National Amyloidosis Centre, University College London Medical School, Royal Free Campus; A. Martini, MD, Professor, Istituto Giannina Gaslini, UO Pediatria II, Reumatologia; N. Ruperto, MD, MPH, Istituto Giannina Gaslini, UO Pediatria II, Reumatologia; M. Gattorno, MD, Istituto Giannina Gaslini, UO Pediatria II, Reumatologia; S. Ozen, MD, Pediatric Rheumatology, Hacettepe University, School of Medicine. Dr. Gattorno and Dr. Ozen contributed equally to this manuscript. Address correspondence to Dr. M. Gattorno, UO pediatria II, Istituto G. Gaslini, Largo G. Gaslini 5, 16147, Genoa, Italy. E-mail: marcogattorno@ospedale-gaslini.ge.it. Accepted for publication August 14, 2015.
Isabelle Koné-Paut
From the Familial Mediterranean Fever Arthritis Vasculitis and Orphan Disease Research Center (FAVOR), Gulhane Military Medical Faculty; Epidemiology, Gulhane Military Medical Faculty, Ankara, Turkey; Centre de référence national des maladies auto-inflammatoires, CEREMAI, Rhumatologie pédiatrique, CHU Le Kremlin Bicêtre (APHP, University of Paris SUD), Paris, France; Center of Paediatric and Adolescent Rheumatology, UCL, London, UK; Istituto Giannina Gaslini, UO Pediatria II, Reumatologia, Genoa, Italy; Arabkir Medical Centre, Institute of Child and Adolescents Health, Yerevan, Armenia; Department of Paediatrics, University Medical Center Utrecht, Utrecht, Netherlands; Pediatrics, Meir Medical Centre, Kfar Saba, Israel; Division of Rheumatology, Department of Pediatric Medicine, Bambino Gesù Children’s Hospital, IRCCS, Rome; Rheumatology Unit, Policlinico le Scotte, University of Siena, Siena, Italy; Pediatrie, Centre Multisite Romand de Rhumatologie Pediatrique/Centre Hospitalier, Universitaire Vaudois (CHUV), Lausanne, Switzerland; Pediatric Rheumatology, Université Paris-Descartes, Paris, France; Pediatric Rheumatology, Hacettepe University, School of Medicine, Ankara, Turkey; Reumatologia, Hospital Valle de Hebron, Barcelona, Spain; Pediatrics, Università Cattolica Sacro Cuore, Rome, Italy; Fourth Department of Pediatrics, Aristotle University of Thessaloniki Papageorgiou Hospital, Thessaloniki, Greece; Universitatsklinik fur Kinderheilkunde und Jugendmedizin, Tübingen, Germany; Université Paris-Descartes, Hôpital Necker-Enfants Malades, Centre de référence national pour les Arthrites Juveniles, Unité d’Immunologie, Hématologie et Rhumatologie Pédiatrique, Université Descartes, Sorbonne Paris Cité, Institut IMAGINE, Paris, France; National Amyloidosis Centre, University College London Medical School, Royal Free Campus, London, UK. The Eurofever registry was sponsored by the Autoinflammatory Diseases’ Working Group of the Paediatric Rheumatology European Society and supported by the Executive Agency For Health and Consumers (Project No 2007332) and by Coordination Theme 1 (Health) of the European Community’s FP7 (Eurotraps, grant agreement no. HEALTH-F2-2008-200923). Novartis and SOBI have granted unrestricted educational grants. E. Demirkaya, MD, MSc, FAVOR, Gulhane Military Medical Faculty; C. Saglam, MD, FAVOR, Gulhane Military Medical Faculty; T. Turker, MD, Epidemiology, Gulhane Military Medical Faculty; I. Koné-Paut, MD, CEREMAI, Rhumatologie pédiatrique, CHU Le Kremlin Bicêtre (APHP, University of Paris SUD); P. Woo, MD, Center of Paediatric and Adolescent Rheumatology, UCL; M. Doglio, MD, Istituto Giannina Gaslini, UO Pediatria II, Reumatologia; G. Amaryan, MD, PhD, Arabkir Medical Centre, Institute of Child and Adolescents Health; J. Frenkel, MD, Department of Paediatrics, University Medical Center Utrecht; Y. Uziel, MD, MSc, Pediatrics, Meir Medical Centre; A. Insalaco, MD, Division of Rheumatology, Department of Pediatric Medicine, Bambino Gesù Children’s Hospital, IRCCS; L. Cantarini, MD, Rheumatology Unit, Policlinico le Scotte, University of Siena; M. Hofer, MD, PhD, Pediatrie, Centre Multisite Romand de Rhumatologie Pediatrique/CHUV; S. Boiu, MD, Pediatric Rheumatology, Université Paris-Descartes; A. Duzova, MD, Pediatric Rheumatology, Hacettepe University, School of Medicine; C. Modesto, MD, PhD, Reumatologia, Hospital Valle de Hebron; A. Bryant, MD, Center of Paediatric and Adolescent Rheumatology, UCL; D. Rigante, MD, Pediatrics, Università Cattolica Sacro Cuore; E. Papadopoulou-Alataki, MD, PhD, Fourth Department of Pediatrics, Aristotle University of Thessaloniki Papageorgiou Hospital; S. Guillaume-Czitrom, MD, CEREMAI, Rhumatologie pédiatrique, CHU Le Kremlin Bicêtre (APHP, University of Paris SUD); J. Kuemmerle-Deschner, MD, Universitatsklinik fur Kinderheilkunde und Jugendmedizin; B. Neven, MD, Université Paris-Descartes, Hôpital Necker-Enfants Malades, Centre de référence national pour les Arthrites Juveniles, Unité d’Immunologie, Hématologie et Rhumatologie Pédiatrique, Université Descartes, Sorbonne Paris Cité, Institut IMAGINE; H. Lachmann, MD, National Amyloidosis Centre, University College London Medical School, Royal Free Campus; A. Martini, MD, Professor, Istituto Giannina Gaslini, UO Pediatria II, Reumatologia; N. Ruperto, MD, MPH, Istituto Giannina Gaslini, UO Pediatria II, Reumatologia; M. Gattorno, MD, Istituto Giannina Gaslini, UO Pediatria II, Reumatologia; S. Ozen, MD, Pediatric Rheumatology, Hacettepe University, School of Medicine. Dr. Gattorno and Dr. Ozen contributed equally to this manuscript. Address correspondence to Dr. M. Gattorno, UO pediatria II, Istituto G. Gaslini, Largo G. Gaslini 5, 16147, Genoa, Italy. E-mail: marcogattorno@ospedale-gaslini.ge.it. Accepted for publication August 14, 2015.
Pat Woo
From the Familial Mediterranean Fever Arthritis Vasculitis and Orphan Disease Research Center (FAVOR), Gulhane Military Medical Faculty; Epidemiology, Gulhane Military Medical Faculty, Ankara, Turkey; Centre de référence national des maladies auto-inflammatoires, CEREMAI, Rhumatologie pédiatrique, CHU Le Kremlin Bicêtre (APHP, University of Paris SUD), Paris, France; Center of Paediatric and Adolescent Rheumatology, UCL, London, UK; Istituto Giannina Gaslini, UO Pediatria II, Reumatologia, Genoa, Italy; Arabkir Medical Centre, Institute of Child and Adolescents Health, Yerevan, Armenia; Department of Paediatrics, University Medical Center Utrecht, Utrecht, Netherlands; Pediatrics, Meir Medical Centre, Kfar Saba, Israel; Division of Rheumatology, Department of Pediatric Medicine, Bambino Gesù Children’s Hospital, IRCCS, Rome; Rheumatology Unit, Policlinico le Scotte, University of Siena, Siena, Italy; Pediatrie, Centre Multisite Romand de Rhumatologie Pediatrique/Centre Hospitalier, Universitaire Vaudois (CHUV), Lausanne, Switzerland; Pediatric Rheumatology, Université Paris-Descartes, Paris, France; Pediatric Rheumatology, Hacettepe University, School of Medicine, Ankara, Turkey; Reumatologia, Hospital Valle de Hebron, Barcelona, Spain; Pediatrics, Università Cattolica Sacro Cuore, Rome, Italy; Fourth Department of Pediatrics, Aristotle University of Thessaloniki Papageorgiou Hospital, Thessaloniki, Greece; Universitatsklinik fur Kinderheilkunde und Jugendmedizin, Tübingen, Germany; Université Paris-Descartes, Hôpital Necker-Enfants Malades, Centre de référence national pour les Arthrites Juveniles, Unité d’Immunologie, Hématologie et Rhumatologie Pédiatrique, Université Descartes, Sorbonne Paris Cité, Institut IMAGINE, Paris, France; National Amyloidosis Centre, University College London Medical School, Royal Free Campus, London, UK. The Eurofever registry was sponsored by the Autoinflammatory Diseases’ Working Group of the Paediatric Rheumatology European Society and supported by the Executive Agency For Health and Consumers (Project No 2007332) and by Coordination Theme 1 (Health) of the European Community’s FP7 (Eurotraps, grant agreement no. HEALTH-F2-2008-200923). Novartis and SOBI have granted unrestricted educational grants. E. Demirkaya, MD, MSc, FAVOR, Gulhane Military Medical Faculty; C. Saglam, MD, FAVOR, Gulhane Military Medical Faculty; T. Turker, MD, Epidemiology, Gulhane Military Medical Faculty; I. Koné-Paut, MD, CEREMAI, Rhumatologie pédiatrique, CHU Le Kremlin Bicêtre (APHP, University of Paris SUD); P. Woo, MD, Center of Paediatric and Adolescent Rheumatology, UCL; M. Doglio, MD, Istituto Giannina Gaslini, UO Pediatria II, Reumatologia; G. Amaryan, MD, PhD, Arabkir Medical Centre, Institute of Child and Adolescents Health; J. Frenkel, MD, Department of Paediatrics, University Medical Center Utrecht; Y. Uziel, MD, MSc, Pediatrics, Meir Medical Centre; A. Insalaco, MD, Division of Rheumatology, Department of Pediatric Medicine, Bambino Gesù Children’s Hospital, IRCCS; L. Cantarini, MD, Rheumatology Unit, Policlinico le Scotte, University of Siena; M. Hofer, MD, PhD, Pediatrie, Centre Multisite Romand de Rhumatologie Pediatrique/CHUV; S. Boiu, MD, Pediatric Rheumatology, Université Paris-Descartes; A. Duzova, MD, Pediatric Rheumatology, Hacettepe University, School of Medicine; C. Modesto, MD, PhD, Reumatologia, Hospital Valle de Hebron; A. Bryant, MD, Center of Paediatric and Adolescent Rheumatology, UCL; D. Rigante, MD, Pediatrics, Università Cattolica Sacro Cuore; E. Papadopoulou-Alataki, MD, PhD, Fourth Department of Pediatrics, Aristotle University of Thessaloniki Papageorgiou Hospital; S. Guillaume-Czitrom, MD, CEREMAI, Rhumatologie pédiatrique, CHU Le Kremlin Bicêtre (APHP, University of Paris SUD); J. Kuemmerle-Deschner, MD, Universitatsklinik fur Kinderheilkunde und Jugendmedizin; B. Neven, MD, Université Paris-Descartes, Hôpital Necker-Enfants Malades, Centre de référence national pour les Arthrites Juveniles, Unité d’Immunologie, Hématologie et Rhumatologie Pédiatrique, Université Descartes, Sorbonne Paris Cité, Institut IMAGINE; H. Lachmann, MD, National Amyloidosis Centre, University College London Medical School, Royal Free Campus; A. Martini, MD, Professor, Istituto Giannina Gaslini, UO Pediatria II, Reumatologia; N. Ruperto, MD, MPH, Istituto Giannina Gaslini, UO Pediatria II, Reumatologia; M. Gattorno, MD, Istituto Giannina Gaslini, UO Pediatria II, Reumatologia; S. Ozen, MD, Pediatric Rheumatology, Hacettepe University, School of Medicine. Dr. Gattorno and Dr. Ozen contributed equally to this manuscript. Address correspondence to Dr. M. Gattorno, UO pediatria II, Istituto G. Gaslini, Largo G. Gaslini 5, 16147, Genoa, Italy. E-mail: marcogattorno@ospedale-gaslini.ge.it. Accepted for publication August 14, 2015.
Matteo Doglio
From the Familial Mediterranean Fever Arthritis Vasculitis and Orphan Disease Research Center (FAVOR), Gulhane Military Medical Faculty; Epidemiology, Gulhane Military Medical Faculty, Ankara, Turkey; Centre de référence national des maladies auto-inflammatoires, CEREMAI, Rhumatologie pédiatrique, CHU Le Kremlin Bicêtre (APHP, University of Paris SUD), Paris, France; Center of Paediatric and Adolescent Rheumatology, UCL, London, UK; Istituto Giannina Gaslini, UO Pediatria II, Reumatologia, Genoa, Italy; Arabkir Medical Centre, Institute of Child and Adolescents Health, Yerevan, Armenia; Department of Paediatrics, University Medical Center Utrecht, Utrecht, Netherlands; Pediatrics, Meir Medical Centre, Kfar Saba, Israel; Division of Rheumatology, Department of Pediatric Medicine, Bambino Gesù Children’s Hospital, IRCCS, Rome; Rheumatology Unit, Policlinico le Scotte, University of Siena, Siena, Italy; Pediatrie, Centre Multisite Romand de Rhumatologie Pediatrique/Centre Hospitalier, Universitaire Vaudois (CHUV), Lausanne, Switzerland; Pediatric Rheumatology, Université Paris-Descartes, Paris, France; Pediatric Rheumatology, Hacettepe University, School of Medicine, Ankara, Turkey; Reumatologia, Hospital Valle de Hebron, Barcelona, Spain; Pediatrics, Università Cattolica Sacro Cuore, Rome, Italy; Fourth Department of Pediatrics, Aristotle University of Thessaloniki Papageorgiou Hospital, Thessaloniki, Greece; Universitatsklinik fur Kinderheilkunde und Jugendmedizin, Tübingen, Germany; Université Paris-Descartes, Hôpital Necker-Enfants Malades, Centre de référence national pour les Arthrites Juveniles, Unité d’Immunologie, Hématologie et Rhumatologie Pédiatrique, Université Descartes, Sorbonne Paris Cité, Institut IMAGINE, Paris, France; National Amyloidosis Centre, University College London Medical School, Royal Free Campus, London, UK. The Eurofever registry was sponsored by the Autoinflammatory Diseases’ Working Group of the Paediatric Rheumatology European Society and supported by the Executive Agency For Health and Consumers (Project No 2007332) and by Coordination Theme 1 (Health) of the European Community’s FP7 (Eurotraps, grant agreement no. HEALTH-F2-2008-200923). Novartis and SOBI have granted unrestricted educational grants. E. Demirkaya, MD, MSc, FAVOR, Gulhane Military Medical Faculty; C. Saglam, MD, FAVOR, Gulhane Military Medical Faculty; T. Turker, MD, Epidemiology, Gulhane Military Medical Faculty; I. Koné-Paut, MD, CEREMAI, Rhumatologie pédiatrique, CHU Le Kremlin Bicêtre (APHP, University of Paris SUD); P. Woo, MD, Center of Paediatric and Adolescent Rheumatology, UCL; M. Doglio, MD, Istituto Giannina Gaslini, UO Pediatria II, Reumatologia; G. Amaryan, MD, PhD, Arabkir Medical Centre, Institute of Child and Adolescents Health; J. Frenkel, MD, Department of Paediatrics, University Medical Center Utrecht; Y. Uziel, MD, MSc, Pediatrics, Meir Medical Centre; A. Insalaco, MD, Division of Rheumatology, Department of Pediatric Medicine, Bambino Gesù Children’s Hospital, IRCCS; L. Cantarini, MD, Rheumatology Unit, Policlinico le Scotte, University of Siena; M. Hofer, MD, PhD, Pediatrie, Centre Multisite Romand de Rhumatologie Pediatrique/CHUV; S. Boiu, MD, Pediatric Rheumatology, Université Paris-Descartes; A. Duzova, MD, Pediatric Rheumatology, Hacettepe University, School of Medicine; C. Modesto, MD, PhD, Reumatologia, Hospital Valle de Hebron; A. Bryant, MD, Center of Paediatric and Adolescent Rheumatology, UCL; D. Rigante, MD, Pediatrics, Università Cattolica Sacro Cuore; E. Papadopoulou-Alataki, MD, PhD, Fourth Department of Pediatrics, Aristotle University of Thessaloniki Papageorgiou Hospital; S. Guillaume-Czitrom, MD, CEREMAI, Rhumatologie pédiatrique, CHU Le Kremlin Bicêtre (APHP, University of Paris SUD); J. Kuemmerle-Deschner, MD, Universitatsklinik fur Kinderheilkunde und Jugendmedizin; B. Neven, MD, Université Paris-Descartes, Hôpital Necker-Enfants Malades, Centre de référence national pour les Arthrites Juveniles, Unité d’Immunologie, Hématologie et Rhumatologie Pédiatrique, Université Descartes, Sorbonne Paris Cité, Institut IMAGINE; H. Lachmann, MD, National Amyloidosis Centre, University College London Medical School, Royal Free Campus; A. Martini, MD, Professor, Istituto Giannina Gaslini, UO Pediatria II, Reumatologia; N. Ruperto, MD, MPH, Istituto Giannina Gaslini, UO Pediatria II, Reumatologia; M. Gattorno, MD, Istituto Giannina Gaslini, UO Pediatria II, Reumatologia; S. Ozen, MD, Pediatric Rheumatology, Hacettepe University, School of Medicine. Dr. Gattorno and Dr. Ozen contributed equally to this manuscript. Address correspondence to Dr. M. Gattorno, UO pediatria II, Istituto G. Gaslini, Largo G. Gaslini 5, 16147, Genoa, Italy. E-mail: marcogattorno@ospedale-gaslini.ge.it. Accepted for publication August 14, 2015.
Gayane Amaryan
From the Familial Mediterranean Fever Arthritis Vasculitis and Orphan Disease Research Center (FAVOR), Gulhane Military Medical Faculty; Epidemiology, Gulhane Military Medical Faculty, Ankara, Turkey; Centre de référence national des maladies auto-inflammatoires, CEREMAI, Rhumatologie pédiatrique, CHU Le Kremlin Bicêtre (APHP, University of Paris SUD), Paris, France; Center of Paediatric and Adolescent Rheumatology, UCL, London, UK; Istituto Giannina Gaslini, UO Pediatria II, Reumatologia, Genoa, Italy; Arabkir Medical Centre, Institute of Child and Adolescents Health, Yerevan, Armenia; Department of Paediatrics, University Medical Center Utrecht, Utrecht, Netherlands; Pediatrics, Meir Medical Centre, Kfar Saba, Israel; Division of Rheumatology, Department of Pediatric Medicine, Bambino Gesù Children’s Hospital, IRCCS, Rome; Rheumatology Unit, Policlinico le Scotte, University of Siena, Siena, Italy; Pediatrie, Centre Multisite Romand de Rhumatologie Pediatrique/Centre Hospitalier, Universitaire Vaudois (CHUV), Lausanne, Switzerland; Pediatric Rheumatology, Université Paris-Descartes, Paris, France; Pediatric Rheumatology, Hacettepe University, School of Medicine, Ankara, Turkey; Reumatologia, Hospital Valle de Hebron, Barcelona, Spain; Pediatrics, Università Cattolica Sacro Cuore, Rome, Italy; Fourth Department of Pediatrics, Aristotle University of Thessaloniki Papageorgiou Hospital, Thessaloniki, Greece; Universitatsklinik fur Kinderheilkunde und Jugendmedizin, Tübingen, Germany; Université Paris-Descartes, Hôpital Necker-Enfants Malades, Centre de référence national pour les Arthrites Juveniles, Unité d’Immunologie, Hématologie et Rhumatologie Pédiatrique, Université Descartes, Sorbonne Paris Cité, Institut IMAGINE, Paris, France; National Amyloidosis Centre, University College London Medical School, Royal Free Campus, London, UK. The Eurofever registry was sponsored by the Autoinflammatory Diseases’ Working Group of the Paediatric Rheumatology European Society and supported by the Executive Agency For Health and Consumers (Project No 2007332) and by Coordination Theme 1 (Health) of the European Community’s FP7 (Eurotraps, grant agreement no. HEALTH-F2-2008-200923). Novartis and SOBI have granted unrestricted educational grants. E. Demirkaya, MD, MSc, FAVOR, Gulhane Military Medical Faculty; C. Saglam, MD, FAVOR, Gulhane Military Medical Faculty; T. Turker, MD, Epidemiology, Gulhane Military Medical Faculty; I. Koné-Paut, MD, CEREMAI, Rhumatologie pédiatrique, CHU Le Kremlin Bicêtre (APHP, University of Paris SUD); P. Woo, MD, Center of Paediatric and Adolescent Rheumatology, UCL; M. Doglio, MD, Istituto Giannina Gaslini, UO Pediatria II, Reumatologia; G. Amaryan, MD, PhD, Arabkir Medical Centre, Institute of Child and Adolescents Health; J. Frenkel, MD, Department of Paediatrics, University Medical Center Utrecht; Y. Uziel, MD, MSc, Pediatrics, Meir Medical Centre; A. Insalaco, MD, Division of Rheumatology, Department of Pediatric Medicine, Bambino Gesù Children’s Hospital, IRCCS; L. Cantarini, MD, Rheumatology Unit, Policlinico le Scotte, University of Siena; M. Hofer, MD, PhD, Pediatrie, Centre Multisite Romand de Rhumatologie Pediatrique/CHUV; S. Boiu, MD, Pediatric Rheumatology, Université Paris-Descartes; A. Duzova, MD, Pediatric Rheumatology, Hacettepe University, School of Medicine; C. Modesto, MD, PhD, Reumatologia, Hospital Valle de Hebron; A. Bryant, MD, Center of Paediatric and Adolescent Rheumatology, UCL; D. Rigante, MD, Pediatrics, Università Cattolica Sacro Cuore; E. Papadopoulou-Alataki, MD, PhD, Fourth Department of Pediatrics, Aristotle University of Thessaloniki Papageorgiou Hospital; S. Guillaume-Czitrom, MD, CEREMAI, Rhumatologie pédiatrique, CHU Le Kremlin Bicêtre (APHP, University of Paris SUD); J. Kuemmerle-Deschner, MD, Universitatsklinik fur Kinderheilkunde und Jugendmedizin; B. Neven, MD, Université Paris-Descartes, Hôpital Necker-Enfants Malades, Centre de référence national pour les Arthrites Juveniles, Unité d’Immunologie, Hématologie et Rhumatologie Pédiatrique, Université Descartes, Sorbonne Paris Cité, Institut IMAGINE; H. Lachmann, MD, National Amyloidosis Centre, University College London Medical School, Royal Free Campus; A. Martini, MD, Professor, Istituto Giannina Gaslini, UO Pediatria II, Reumatologia; N. Ruperto, MD, MPH, Istituto Giannina Gaslini, UO Pediatria II, Reumatologia; M. Gattorno, MD, Istituto Giannina Gaslini, UO Pediatria II, Reumatologia; S. Ozen, MD, Pediatric Rheumatology, Hacettepe University, School of Medicine. Dr. Gattorno and Dr. Ozen contributed equally to this manuscript. Address correspondence to Dr. M. Gattorno, UO pediatria II, Istituto G. Gaslini, Largo G. Gaslini 5, 16147, Genoa, Italy. E-mail: marcogattorno@ospedale-gaslini.ge.it. Accepted for publication August 14, 2015.
Joost Frenkel
From the Familial Mediterranean Fever Arthritis Vasculitis and Orphan Disease Research Center (FAVOR), Gulhane Military Medical Faculty; Epidemiology, Gulhane Military Medical Faculty, Ankara, Turkey; Centre de référence national des maladies auto-inflammatoires, CEREMAI, Rhumatologie pédiatrique, CHU Le Kremlin Bicêtre (APHP, University of Paris SUD), Paris, France; Center of Paediatric and Adolescent Rheumatology, UCL, London, UK; Istituto Giannina Gaslini, UO Pediatria II, Reumatologia, Genoa, Italy; Arabkir Medical Centre, Institute of Child and Adolescents Health, Yerevan, Armenia; Department of Paediatrics, University Medical Center Utrecht, Utrecht, Netherlands; Pediatrics, Meir Medical Centre, Kfar Saba, Israel; Division of Rheumatology, Department of Pediatric Medicine, Bambino Gesù Children’s Hospital, IRCCS, Rome; Rheumatology Unit, Policlinico le Scotte, University of Siena, Siena, Italy; Pediatrie, Centre Multisite Romand de Rhumatologie Pediatrique/Centre Hospitalier, Universitaire Vaudois (CHUV), Lausanne, Switzerland; Pediatric Rheumatology, Université Paris-Descartes, Paris, France; Pediatric Rheumatology, Hacettepe University, School of Medicine, Ankara, Turkey; Reumatologia, Hospital Valle de Hebron, Barcelona, Spain; Pediatrics, Università Cattolica Sacro Cuore, Rome, Italy; Fourth Department of Pediatrics, Aristotle University of Thessaloniki Papageorgiou Hospital, Thessaloniki, Greece; Universitatsklinik fur Kinderheilkunde und Jugendmedizin, Tübingen, Germany; Université Paris-Descartes, Hôpital Necker-Enfants Malades, Centre de référence national pour les Arthrites Juveniles, Unité d’Immunologie, Hématologie et Rhumatologie Pédiatrique, Université Descartes, Sorbonne Paris Cité, Institut IMAGINE, Paris, France; National Amyloidosis Centre, University College London Medical School, Royal Free Campus, London, UK. The Eurofever registry was sponsored by the Autoinflammatory Diseases’ Working Group of the Paediatric Rheumatology European Society and supported by the Executive Agency For Health and Consumers (Project No 2007332) and by Coordination Theme 1 (Health) of the European Community’s FP7 (Eurotraps, grant agreement no. HEALTH-F2-2008-200923). Novartis and SOBI have granted unrestricted educational grants. E. Demirkaya, MD, MSc, FAVOR, Gulhane Military Medical Faculty; C. Saglam, MD, FAVOR, Gulhane Military Medical Faculty; T. Turker, MD, Epidemiology, Gulhane Military Medical Faculty; I. Koné-Paut, MD, CEREMAI, Rhumatologie pédiatrique, CHU Le Kremlin Bicêtre (APHP, University of Paris SUD); P. Woo, MD, Center of Paediatric and Adolescent Rheumatology, UCL; M. Doglio, MD, Istituto Giannina Gaslini, UO Pediatria II, Reumatologia; G. Amaryan, MD, PhD, Arabkir Medical Centre, Institute of Child and Adolescents Health; J. Frenkel, MD, Department of Paediatrics, University Medical Center Utrecht; Y. Uziel, MD, MSc, Pediatrics, Meir Medical Centre; A. Insalaco, MD, Division of Rheumatology, Department of Pediatric Medicine, Bambino Gesù Children’s Hospital, IRCCS; L. Cantarini, MD, Rheumatology Unit, Policlinico le Scotte, University of Siena; M. Hofer, MD, PhD, Pediatrie, Centre Multisite Romand de Rhumatologie Pediatrique/CHUV; S. Boiu, MD, Pediatric Rheumatology, Université Paris-Descartes; A. Duzova, MD, Pediatric Rheumatology, Hacettepe University, School of Medicine; C. Modesto, MD, PhD, Reumatologia, Hospital Valle de Hebron; A. Bryant, MD, Center of Paediatric and Adolescent Rheumatology, UCL; D. Rigante, MD, Pediatrics, Università Cattolica Sacro Cuore; E. Papadopoulou-Alataki, MD, PhD, Fourth Department of Pediatrics, Aristotle University of Thessaloniki Papageorgiou Hospital; S. Guillaume-Czitrom, MD, CEREMAI, Rhumatologie pédiatrique, CHU Le Kremlin Bicêtre (APHP, University of Paris SUD); J. Kuemmerle-Deschner, MD, Universitatsklinik fur Kinderheilkunde und Jugendmedizin; B. Neven, MD, Université Paris-Descartes, Hôpital Necker-Enfants Malades, Centre de référence national pour les Arthrites Juveniles, Unité d’Immunologie, Hématologie et Rhumatologie Pédiatrique, Université Descartes, Sorbonne Paris Cité, Institut IMAGINE; H. Lachmann, MD, National Amyloidosis Centre, University College London Medical School, Royal Free Campus; A. Martini, MD, Professor, Istituto Giannina Gaslini, UO Pediatria II, Reumatologia; N. Ruperto, MD, MPH, Istituto Giannina Gaslini, UO Pediatria II, Reumatologia; M. Gattorno, MD, Istituto Giannina Gaslini, UO Pediatria II, Reumatologia; S. Ozen, MD, Pediatric Rheumatology, Hacettepe University, School of Medicine. Dr. Gattorno and Dr. Ozen contributed equally to this manuscript. Address correspondence to Dr. M. Gattorno, UO pediatria II, Istituto G. Gaslini, Largo G. Gaslini 5, 16147, Genoa, Italy. E-mail: marcogattorno@ospedale-gaslini.ge.it. Accepted for publication August 14, 2015.
Yosef Uziel
From the Familial Mediterranean Fever Arthritis Vasculitis and Orphan Disease Research Center (FAVOR), Gulhane Military Medical Faculty; Epidemiology, Gulhane Military Medical Faculty, Ankara, Turkey; Centre de référence national des maladies auto-inflammatoires, CEREMAI, Rhumatologie pédiatrique, CHU Le Kremlin Bicêtre (APHP, University of Paris SUD), Paris, France; Center of Paediatric and Adolescent Rheumatology, UCL, London, UK; Istituto Giannina Gaslini, UO Pediatria II, Reumatologia, Genoa, Italy; Arabkir Medical Centre, Institute of Child and Adolescents Health, Yerevan, Armenia; Department of Paediatrics, University Medical Center Utrecht, Utrecht, Netherlands; Pediatrics, Meir Medical Centre, Kfar Saba, Israel; Division of Rheumatology, Department of Pediatric Medicine, Bambino Gesù Children’s Hospital, IRCCS, Rome; Rheumatology Unit, Policlinico le Scotte, University of Siena, Siena, Italy; Pediatrie, Centre Multisite Romand de Rhumatologie Pediatrique/Centre Hospitalier, Universitaire Vaudois (CHUV), Lausanne, Switzerland; Pediatric Rheumatology, Université Paris-Descartes, Paris, France; Pediatric Rheumatology, Hacettepe University, School of Medicine, Ankara, Turkey; Reumatologia, Hospital Valle de Hebron, Barcelona, Spain; Pediatrics, Università Cattolica Sacro Cuore, Rome, Italy; Fourth Department of Pediatrics, Aristotle University of Thessaloniki Papageorgiou Hospital, Thessaloniki, Greece; Universitatsklinik fur Kinderheilkunde und Jugendmedizin, Tübingen, Germany; Université Paris-Descartes, Hôpital Necker-Enfants Malades, Centre de référence national pour les Arthrites Juveniles, Unité d’Immunologie, Hématologie et Rhumatologie Pédiatrique, Université Descartes, Sorbonne Paris Cité, Institut IMAGINE, Paris, France; National Amyloidosis Centre, University College London Medical School, Royal Free Campus, London, UK. The Eurofever registry was sponsored by the Autoinflammatory Diseases’ Working Group of the Paediatric Rheumatology European Society and supported by the Executive Agency For Health and Consumers (Project No 2007332) and by Coordination Theme 1 (Health) of the European Community’s FP7 (Eurotraps, grant agreement no. HEALTH-F2-2008-200923). Novartis and SOBI have granted unrestricted educational grants. E. Demirkaya, MD, MSc, FAVOR, Gulhane Military Medical Faculty; C. Saglam, MD, FAVOR, Gulhane Military Medical Faculty; T. Turker, MD, Epidemiology, Gulhane Military Medical Faculty; I. Koné-Paut, MD, CEREMAI, Rhumatologie pédiatrique, CHU Le Kremlin Bicêtre (APHP, University of Paris SUD); P. Woo, MD, Center of Paediatric and Adolescent Rheumatology, UCL; M. Doglio, MD, Istituto Giannina Gaslini, UO Pediatria II, Reumatologia; G. Amaryan, MD, PhD, Arabkir Medical Centre, Institute of Child and Adolescents Health; J. Frenkel, MD, Department of Paediatrics, University Medical Center Utrecht; Y. Uziel, MD, MSc, Pediatrics, Meir Medical Centre; A. Insalaco, MD, Division of Rheumatology, Department of Pediatric Medicine, Bambino Gesù Children’s Hospital, IRCCS; L. Cantarini, MD, Rheumatology Unit, Policlinico le Scotte, University of Siena; M. Hofer, MD, PhD, Pediatrie, Centre Multisite Romand de Rhumatologie Pediatrique/CHUV; S. Boiu, MD, Pediatric Rheumatology, Université Paris-Descartes; A. Duzova, MD, Pediatric Rheumatology, Hacettepe University, School of Medicine; C. Modesto, MD, PhD, Reumatologia, Hospital Valle de Hebron; A. Bryant, MD, Center of Paediatric and Adolescent Rheumatology, UCL; D. Rigante, MD, Pediatrics, Università Cattolica Sacro Cuore; E. Papadopoulou-Alataki, MD, PhD, Fourth Department of Pediatrics, Aristotle University of Thessaloniki Papageorgiou Hospital; S. Guillaume-Czitrom, MD, CEREMAI, Rhumatologie pédiatrique, CHU Le Kremlin Bicêtre (APHP, University of Paris SUD); J. Kuemmerle-Deschner, MD, Universitatsklinik fur Kinderheilkunde und Jugendmedizin; B. Neven, MD, Université Paris-Descartes, Hôpital Necker-Enfants Malades, Centre de référence national pour les Arthrites Juveniles, Unité d’Immunologie, Hématologie et Rhumatologie Pédiatrique, Université Descartes, Sorbonne Paris Cité, Institut IMAGINE; H. Lachmann, MD, National Amyloidosis Centre, University College London Medical School, Royal Free Campus; A. Martini, MD, Professor, Istituto Giannina Gaslini, UO Pediatria II, Reumatologia; N. Ruperto, MD, MPH, Istituto Giannina Gaslini, UO Pediatria II, Reumatologia; M. Gattorno, MD, Istituto Giannina Gaslini, UO Pediatria II, Reumatologia; S. Ozen, MD, Pediatric Rheumatology, Hacettepe University, School of Medicine. Dr. Gattorno and Dr. Ozen contributed equally to this manuscript. Address correspondence to Dr. M. Gattorno, UO pediatria II, Istituto G. Gaslini, Largo G. Gaslini 5, 16147, Genoa, Italy. E-mail: marcogattorno@ospedale-gaslini.ge.it. Accepted for publication August 14, 2015.
Antonella Insalaco
From the Familial Mediterranean Fever Arthritis Vasculitis and Orphan Disease Research Center (FAVOR), Gulhane Military Medical Faculty; Epidemiology, Gulhane Military Medical Faculty, Ankara, Turkey; Centre de référence national des maladies auto-inflammatoires, CEREMAI, Rhumatologie pédiatrique, CHU Le Kremlin Bicêtre (APHP, University of Paris SUD), Paris, France; Center of Paediatric and Adolescent Rheumatology, UCL, London, UK; Istituto Giannina Gaslini, UO Pediatria II, Reumatologia, Genoa, Italy; Arabkir Medical Centre, Institute of Child and Adolescents Health, Yerevan, Armenia; Department of Paediatrics, University Medical Center Utrecht, Utrecht, Netherlands; Pediatrics, Meir Medical Centre, Kfar Saba, Israel; Division of Rheumatology, Department of Pediatric Medicine, Bambino Gesù Children’s Hospital, IRCCS, Rome; Rheumatology Unit, Policlinico le Scotte, University of Siena, Siena, Italy; Pediatrie, Centre Multisite Romand de Rhumatologie Pediatrique/Centre Hospitalier, Universitaire Vaudois (CHUV), Lausanne, Switzerland; Pediatric Rheumatology, Université Paris-Descartes, Paris, France; Pediatric Rheumatology, Hacettepe University, School of Medicine, Ankara, Turkey; Reumatologia, Hospital Valle de Hebron, Barcelona, Spain; Pediatrics, Università Cattolica Sacro Cuore, Rome, Italy; Fourth Department of Pediatrics, Aristotle University of Thessaloniki Papageorgiou Hospital, Thessaloniki, Greece; Universitatsklinik fur Kinderheilkunde und Jugendmedizin, Tübingen, Germany; Université Paris-Descartes, Hôpital Necker-Enfants Malades, Centre de référence national pour les Arthrites Juveniles, Unité d’Immunologie, Hématologie et Rhumatologie Pédiatrique, Université Descartes, Sorbonne Paris Cité, Institut IMAGINE, Paris, France; National Amyloidosis Centre, University College London Medical School, Royal Free Campus, London, UK. The Eurofever registry was sponsored by the Autoinflammatory Diseases’ Working Group of the Paediatric Rheumatology European Society and supported by the Executive Agency For Health and Consumers (Project No 2007332) and by Coordination Theme 1 (Health) of the European Community’s FP7 (Eurotraps, grant agreement no. HEALTH-F2-2008-200923). Novartis and SOBI have granted unrestricted educational grants. E. Demirkaya, MD, MSc, FAVOR, Gulhane Military Medical Faculty; C. Saglam, MD, FAVOR, Gulhane Military Medical Faculty; T. Turker, MD, Epidemiology, Gulhane Military Medical Faculty; I. Koné-Paut, MD, CEREMAI, Rhumatologie pédiatrique, CHU Le Kremlin Bicêtre (APHP, University of Paris SUD); P. Woo, MD, Center of Paediatric and Adolescent Rheumatology, UCL; M. Doglio, MD, Istituto Giannina Gaslini, UO Pediatria II, Reumatologia; G. Amaryan, MD, PhD, Arabkir Medical Centre, Institute of Child and Adolescents Health; J. Frenkel, MD, Department of Paediatrics, University Medical Center Utrecht; Y. Uziel, MD, MSc, Pediatrics, Meir Medical Centre; A. Insalaco, MD, Division of Rheumatology, Department of Pediatric Medicine, Bambino Gesù Children’s Hospital, IRCCS; L. Cantarini, MD, Rheumatology Unit, Policlinico le Scotte, University of Siena; M. Hofer, MD, PhD, Pediatrie, Centre Multisite Romand de Rhumatologie Pediatrique/CHUV; S. Boiu, MD, Pediatric Rheumatology, Université Paris-Descartes; A. Duzova, MD, Pediatric Rheumatology, Hacettepe University, School of Medicine; C. Modesto, MD, PhD, Reumatologia, Hospital Valle de Hebron; A. Bryant, MD, Center of Paediatric and Adolescent Rheumatology, UCL; D. Rigante, MD, Pediatrics, Università Cattolica Sacro Cuore; E. Papadopoulou-Alataki, MD, PhD, Fourth Department of Pediatrics, Aristotle University of Thessaloniki Papageorgiou Hospital; S. Guillaume-Czitrom, MD, CEREMAI, Rhumatologie pédiatrique, CHU Le Kremlin Bicêtre (APHP, University of Paris SUD); J. Kuemmerle-Deschner, MD, Universitatsklinik fur Kinderheilkunde und Jugendmedizin; B. Neven, MD, Université Paris-Descartes, Hôpital Necker-Enfants Malades, Centre de référence national pour les Arthrites Juveniles, Unité d’Immunologie, Hématologie et Rhumatologie Pédiatrique, Université Descartes, Sorbonne Paris Cité, Institut IMAGINE; H. Lachmann, MD, National Amyloidosis Centre, University College London Medical School, Royal Free Campus; A. Martini, MD, Professor, Istituto Giannina Gaslini, UO Pediatria II, Reumatologia; N. Ruperto, MD, MPH, Istituto Giannina Gaslini, UO Pediatria II, Reumatologia; M. Gattorno, MD, Istituto Giannina Gaslini, UO Pediatria II, Reumatologia; S. Ozen, MD, Pediatric Rheumatology, Hacettepe University, School of Medicine. Dr. Gattorno and Dr. Ozen contributed equally to this manuscript. Address correspondence to Dr. M. Gattorno, UO pediatria II, Istituto G. Gaslini, Largo G. Gaslini 5, 16147, Genoa, Italy. E-mail: marcogattorno@ospedale-gaslini.ge.it. Accepted for publication August 14, 2015.
Luca Cantarini
From the Familial Mediterranean Fever Arthritis Vasculitis and Orphan Disease Research Center (FAVOR), Gulhane Military Medical Faculty; Epidemiology, Gulhane Military Medical Faculty, Ankara, Turkey; Centre de référence national des maladies auto-inflammatoires, CEREMAI, Rhumatologie pédiatrique, CHU Le Kremlin Bicêtre (APHP, University of Paris SUD), Paris, France; Center of Paediatric and Adolescent Rheumatology, UCL, London, UK; Istituto Giannina Gaslini, UO Pediatria II, Reumatologia, Genoa, Italy; Arabkir Medical Centre, Institute of Child and Adolescents Health, Yerevan, Armenia; Department of Paediatrics, University Medical Center Utrecht, Utrecht, Netherlands; Pediatrics, Meir Medical Centre, Kfar Saba, Israel; Division of Rheumatology, Department of Pediatric Medicine, Bambino Gesù Children’s Hospital, IRCCS, Rome; Rheumatology Unit, Policlinico le Scotte, University of Siena, Siena, Italy; Pediatrie, Centre Multisite Romand de Rhumatologie Pediatrique/Centre Hospitalier, Universitaire Vaudois (CHUV), Lausanne, Switzerland; Pediatric Rheumatology, Université Paris-Descartes, Paris, France; Pediatric Rheumatology, Hacettepe University, School of Medicine, Ankara, Turkey; Reumatologia, Hospital Valle de Hebron, Barcelona, Spain; Pediatrics, Università Cattolica Sacro Cuore, Rome, Italy; Fourth Department of Pediatrics, Aristotle University of Thessaloniki Papageorgiou Hospital, Thessaloniki, Greece; Universitatsklinik fur Kinderheilkunde und Jugendmedizin, Tübingen, Germany; Université Paris-Descartes, Hôpital Necker-Enfants Malades, Centre de référence national pour les Arthrites Juveniles, Unité d’Immunologie, Hématologie et Rhumatologie Pédiatrique, Université Descartes, Sorbonne Paris Cité, Institut IMAGINE, Paris, France; National Amyloidosis Centre, University College London Medical School, Royal Free Campus, London, UK. The Eurofever registry was sponsored by the Autoinflammatory Diseases’ Working Group of the Paediatric Rheumatology European Society and supported by the Executive Agency For Health and Consumers (Project No 2007332) and by Coordination Theme 1 (Health) of the European Community’s FP7 (Eurotraps, grant agreement no. HEALTH-F2-2008-200923). Novartis and SOBI have granted unrestricted educational grants. E. Demirkaya, MD, MSc, FAVOR, Gulhane Military Medical Faculty; C. Saglam, MD, FAVOR, Gulhane Military Medical Faculty; T. Turker, MD, Epidemiology, Gulhane Military Medical Faculty; I. Koné-Paut, MD, CEREMAI, Rhumatologie pédiatrique, CHU Le Kremlin Bicêtre (APHP, University of Paris SUD); P. Woo, MD, Center of Paediatric and Adolescent Rheumatology, UCL; M. Doglio, MD, Istituto Giannina Gaslini, UO Pediatria II, Reumatologia; G. Amaryan, MD, PhD, Arabkir Medical Centre, Institute of Child and Adolescents Health; J. Frenkel, MD, Department of Paediatrics, University Medical Center Utrecht; Y. Uziel, MD, MSc, Pediatrics, Meir Medical Centre; A. Insalaco, MD, Division of Rheumatology, Department of Pediatric Medicine, Bambino Gesù Children’s Hospital, IRCCS; L. Cantarini, MD, Rheumatology Unit, Policlinico le Scotte, University of Siena; M. Hofer, MD, PhD, Pediatrie, Centre Multisite Romand de Rhumatologie Pediatrique/CHUV; S. Boiu, MD, Pediatric Rheumatology, Université Paris-Descartes; A. Duzova, MD, Pediatric Rheumatology, Hacettepe University, School of Medicine; C. Modesto, MD, PhD, Reumatologia, Hospital Valle de Hebron; A. Bryant, MD, Center of Paediatric and Adolescent Rheumatology, UCL; D. Rigante, MD, Pediatrics, Università Cattolica Sacro Cuore; E. Papadopoulou-Alataki, MD, PhD, Fourth Department of Pediatrics, Aristotle University of Thessaloniki Papageorgiou Hospital; S. Guillaume-Czitrom, MD, CEREMAI, Rhumatologie pédiatrique, CHU Le Kremlin Bicêtre (APHP, University of Paris SUD); J. Kuemmerle-Deschner, MD, Universitatsklinik fur Kinderheilkunde und Jugendmedizin; B. Neven, MD, Université Paris-Descartes, Hôpital Necker-Enfants Malades, Centre de référence national pour les Arthrites Juveniles, Unité d’Immunologie, Hématologie et Rhumatologie Pédiatrique, Université Descartes, Sorbonne Paris Cité, Institut IMAGINE; H. Lachmann, MD, National Amyloidosis Centre, University College London Medical School, Royal Free Campus; A. Martini, MD, Professor, Istituto Giannina Gaslini, UO Pediatria II, Reumatologia; N. Ruperto, MD, MPH, Istituto Giannina Gaslini, UO Pediatria II, Reumatologia; M. Gattorno, MD, Istituto Giannina Gaslini, UO Pediatria II, Reumatologia; S. Ozen, MD, Pediatric Rheumatology, Hacettepe University, School of Medicine. Dr. Gattorno and Dr. Ozen contributed equally to this manuscript. Address correspondence to Dr. M. Gattorno, UO pediatria II, Istituto G. Gaslini, Largo G. Gaslini 5, 16147, Genoa, Italy. E-mail: marcogattorno@ospedale-gaslini.ge.it. Accepted for publication August 14, 2015.
Michael Hofer
From the Familial Mediterranean Fever Arthritis Vasculitis and Orphan Disease Research Center (FAVOR), Gulhane Military Medical Faculty; Epidemiology, Gulhane Military Medical Faculty, Ankara, Turkey; Centre de référence national des maladies auto-inflammatoires, CEREMAI, Rhumatologie pédiatrique, CHU Le Kremlin Bicêtre (APHP, University of Paris SUD), Paris, France; Center of Paediatric and Adolescent Rheumatology, UCL, London, UK; Istituto Giannina Gaslini, UO Pediatria II, Reumatologia, Genoa, Italy; Arabkir Medical Centre, Institute of Child and Adolescents Health, Yerevan, Armenia; Department of Paediatrics, University Medical Center Utrecht, Utrecht, Netherlands; Pediatrics, Meir Medical Centre, Kfar Saba, Israel; Division of Rheumatology, Department of Pediatric Medicine, Bambino Gesù Children’s Hospital, IRCCS, Rome; Rheumatology Unit, Policlinico le Scotte, University of Siena, Siena, Italy; Pediatrie, Centre Multisite Romand de Rhumatologie Pediatrique/Centre Hospitalier, Universitaire Vaudois (CHUV), Lausanne, Switzerland; Pediatric Rheumatology, Université Paris-Descartes, Paris, France; Pediatric Rheumatology, Hacettepe University, School of Medicine, Ankara, Turkey; Reumatologia, Hospital Valle de Hebron, Barcelona, Spain; Pediatrics, Università Cattolica Sacro Cuore, Rome, Italy; Fourth Department of Pediatrics, Aristotle University of Thessaloniki Papageorgiou Hospital, Thessaloniki, Greece; Universitatsklinik fur Kinderheilkunde und Jugendmedizin, Tübingen, Germany; Université Paris-Descartes, Hôpital Necker-Enfants Malades, Centre de référence national pour les Arthrites Juveniles, Unité d’Immunologie, Hématologie et Rhumatologie Pédiatrique, Université Descartes, Sorbonne Paris Cité, Institut IMAGINE, Paris, France; National Amyloidosis Centre, University College London Medical School, Royal Free Campus, London, UK. The Eurofever registry was sponsored by the Autoinflammatory Diseases’ Working Group of the Paediatric Rheumatology European Society and supported by the Executive Agency For Health and Consumers (Project No 2007332) and by Coordination Theme 1 (Health) of the European Community’s FP7 (Eurotraps, grant agreement no. HEALTH-F2-2008-200923). Novartis and SOBI have granted unrestricted educational grants. E. Demirkaya, MD, MSc, FAVOR, Gulhane Military Medical Faculty; C. Saglam, MD, FAVOR, Gulhane Military Medical Faculty; T. Turker, MD, Epidemiology, Gulhane Military Medical Faculty; I. Koné-Paut, MD, CEREMAI, Rhumatologie pédiatrique, CHU Le Kremlin Bicêtre (APHP, University of Paris SUD); P. Woo, MD, Center of Paediatric and Adolescent Rheumatology, UCL; M. Doglio, MD, Istituto Giannina Gaslini, UO Pediatria II, Reumatologia; G. Amaryan, MD, PhD, Arabkir Medical Centre, Institute of Child and Adolescents Health; J. Frenkel, MD, Department of Paediatrics, University Medical Center Utrecht; Y. Uziel, MD, MSc, Pediatrics, Meir Medical Centre; A. Insalaco, MD, Division of Rheumatology, Department of Pediatric Medicine, Bambino Gesù Children’s Hospital, IRCCS; L. Cantarini, MD, Rheumatology Unit, Policlinico le Scotte, University of Siena; M. Hofer, MD, PhD, Pediatrie, Centre Multisite Romand de Rhumatologie Pediatrique/CHUV; S. Boiu, MD, Pediatric Rheumatology, Université Paris-Descartes; A. Duzova, MD, Pediatric Rheumatology, Hacettepe University, School of Medicine; C. Modesto, MD, PhD, Reumatologia, Hospital Valle de Hebron; A. Bryant, MD, Center of Paediatric and Adolescent Rheumatology, UCL; D. Rigante, MD, Pediatrics, Università Cattolica Sacro Cuore; E. Papadopoulou-Alataki, MD, PhD, Fourth Department of Pediatrics, Aristotle University of Thessaloniki Papageorgiou Hospital; S. Guillaume-Czitrom, MD, CEREMAI, Rhumatologie pédiatrique, CHU Le Kremlin Bicêtre (APHP, University of Paris SUD); J. Kuemmerle-Deschner, MD, Universitatsklinik fur Kinderheilkunde und Jugendmedizin; B. Neven, MD, Université Paris-Descartes, Hôpital Necker-Enfants Malades, Centre de référence national pour les Arthrites Juveniles, Unité d’Immunologie, Hématologie et Rhumatologie Pédiatrique, Université Descartes, Sorbonne Paris Cité, Institut IMAGINE; H. Lachmann, MD, National Amyloidosis Centre, University College London Medical School, Royal Free Campus; A. Martini, MD, Professor, Istituto Giannina Gaslini, UO Pediatria II, Reumatologia; N. Ruperto, MD, MPH, Istituto Giannina Gaslini, UO Pediatria II, Reumatologia; M. Gattorno, MD, Istituto Giannina Gaslini, UO Pediatria II, Reumatologia; S. Ozen, MD, Pediatric Rheumatology, Hacettepe University, School of Medicine. Dr. Gattorno and Dr. Ozen contributed equally to this manuscript. Address correspondence to Dr. M. Gattorno, UO pediatria II, Istituto G. Gaslini, Largo G. Gaslini 5, 16147, Genoa, Italy. E-mail: marcogattorno@ospedale-gaslini.ge.it. Accepted for publication August 14, 2015.
Sorina Boiu
From the Familial Mediterranean Fever Arthritis Vasculitis and Orphan Disease Research Center (FAVOR), Gulhane Military Medical Faculty; Epidemiology, Gulhane Military Medical Faculty, Ankara, Turkey; Centre de référence national des maladies auto-inflammatoires, CEREMAI, Rhumatologie pédiatrique, CHU Le Kremlin Bicêtre (APHP, University of Paris SUD), Paris, France; Center of Paediatric and Adolescent Rheumatology, UCL, London, UK; Istituto Giannina Gaslini, UO Pediatria II, Reumatologia, Genoa, Italy; Arabkir Medical Centre, Institute of Child and Adolescents Health, Yerevan, Armenia; Department of Paediatrics, University Medical Center Utrecht, Utrecht, Netherlands; Pediatrics, Meir Medical Centre, Kfar Saba, Israel; Division of Rheumatology, Department of Pediatric Medicine, Bambino Gesù Children’s Hospital, IRCCS, Rome; Rheumatology Unit, Policlinico le Scotte, University of Siena, Siena, Italy; Pediatrie, Centre Multisite Romand de Rhumatologie Pediatrique/Centre Hospitalier, Universitaire Vaudois (CHUV), Lausanne, Switzerland; Pediatric Rheumatology, Université Paris-Descartes, Paris, France; Pediatric Rheumatology, Hacettepe University, School of Medicine, Ankara, Turkey; Reumatologia, Hospital Valle de Hebron, Barcelona, Spain; Pediatrics, Università Cattolica Sacro Cuore, Rome, Italy; Fourth Department of Pediatrics, Aristotle University of Thessaloniki Papageorgiou Hospital, Thessaloniki, Greece; Universitatsklinik fur Kinderheilkunde und Jugendmedizin, Tübingen, Germany; Université Paris-Descartes, Hôpital Necker-Enfants Malades, Centre de référence national pour les Arthrites Juveniles, Unité d’Immunologie, Hématologie et Rhumatologie Pédiatrique, Université Descartes, Sorbonne Paris Cité, Institut IMAGINE, Paris, France; National Amyloidosis Centre, University College London Medical School, Royal Free Campus, London, UK. The Eurofever registry was sponsored by the Autoinflammatory Diseases’ Working Group of the Paediatric Rheumatology European Society and supported by the Executive Agency For Health and Consumers (Project No 2007332) and by Coordination Theme 1 (Health) of the European Community’s FP7 (Eurotraps, grant agreement no. HEALTH-F2-2008-200923). Novartis and SOBI have granted unrestricted educational grants. E. Demirkaya, MD, MSc, FAVOR, Gulhane Military Medical Faculty; C. Saglam, MD, FAVOR, Gulhane Military Medical Faculty; T. Turker, MD, Epidemiology, Gulhane Military Medical Faculty; I. Koné-Paut, MD, CEREMAI, Rhumatologie pédiatrique, CHU Le Kremlin Bicêtre (APHP, University of Paris SUD); P. Woo, MD, Center of Paediatric and Adolescent Rheumatology, UCL; M. Doglio, MD, Istituto Giannina Gaslini, UO Pediatria II, Reumatologia; G. Amaryan, MD, PhD, Arabkir Medical Centre, Institute of Child and Adolescents Health; J. Frenkel, MD, Department of Paediatrics, University Medical Center Utrecht; Y. Uziel, MD, MSc, Pediatrics, Meir Medical Centre; A. Insalaco, MD, Division of Rheumatology, Department of Pediatric Medicine, Bambino Gesù Children’s Hospital, IRCCS; L. Cantarini, MD, Rheumatology Unit, Policlinico le Scotte, University of Siena; M. Hofer, MD, PhD, Pediatrie, Centre Multisite Romand de Rhumatologie Pediatrique/CHUV; S. Boiu, MD, Pediatric Rheumatology, Université Paris-Descartes; A. Duzova, MD, Pediatric Rheumatology, Hacettepe University, School of Medicine; C. Modesto, MD, PhD, Reumatologia, Hospital Valle de Hebron; A. Bryant, MD, Center of Paediatric and Adolescent Rheumatology, UCL; D. Rigante, MD, Pediatrics, Università Cattolica Sacro Cuore; E. Papadopoulou-Alataki, MD, PhD, Fourth Department of Pediatrics, Aristotle University of Thessaloniki Papageorgiou Hospital; S. Guillaume-Czitrom, MD, CEREMAI, Rhumatologie pédiatrique, CHU Le Kremlin Bicêtre (APHP, University of Paris SUD); J. Kuemmerle-Deschner, MD, Universitatsklinik fur Kinderheilkunde und Jugendmedizin; B. Neven, MD, Université Paris-Descartes, Hôpital Necker-Enfants Malades, Centre de référence national pour les Arthrites Juveniles, Unité d’Immunologie, Hématologie et Rhumatologie Pédiatrique, Université Descartes, Sorbonne Paris Cité, Institut IMAGINE; H. Lachmann, MD, National Amyloidosis Centre, University College London Medical School, Royal Free Campus; A. Martini, MD, Professor, Istituto Giannina Gaslini, UO Pediatria II, Reumatologia; N. Ruperto, MD, MPH, Istituto Giannina Gaslini, UO Pediatria II, Reumatologia; M. Gattorno, MD, Istituto Giannina Gaslini, UO Pediatria II, Reumatologia; S. Ozen, MD, Pediatric Rheumatology, Hacettepe University, School of Medicine. Dr. Gattorno and Dr. Ozen contributed equally to this manuscript. Address correspondence to Dr. M. Gattorno, UO pediatria II, Istituto G. Gaslini, Largo G. Gaslini 5, 16147, Genoa, Italy. E-mail: marcogattorno@ospedale-gaslini.ge.it. Accepted for publication August 14, 2015.
Ali Duzova
From the Familial Mediterranean Fever Arthritis Vasculitis and Orphan Disease Research Center (FAVOR), Gulhane Military Medical Faculty; Epidemiology, Gulhane Military Medical Faculty, Ankara, Turkey; Centre de référence national des maladies auto-inflammatoires, CEREMAI, Rhumatologie pédiatrique, CHU Le Kremlin Bicêtre (APHP, University of Paris SUD), Paris, France; Center of Paediatric and Adolescent Rheumatology, UCL, London, UK; Istituto Giannina Gaslini, UO Pediatria II, Reumatologia, Genoa, Italy; Arabkir Medical Centre, Institute of Child and Adolescents Health, Yerevan, Armenia; Department of Paediatrics, University Medical Center Utrecht, Utrecht, Netherlands; Pediatrics, Meir Medical Centre, Kfar Saba, Israel; Division of Rheumatology, Department of Pediatric Medicine, Bambino Gesù Children’s Hospital, IRCCS, Rome; Rheumatology Unit, Policlinico le Scotte, University of Siena, Siena, Italy; Pediatrie, Centre Multisite Romand de Rhumatologie Pediatrique/Centre Hospitalier, Universitaire Vaudois (CHUV), Lausanne, Switzerland; Pediatric Rheumatology, Université Paris-Descartes, Paris, France; Pediatric Rheumatology, Hacettepe University, School of Medicine, Ankara, Turkey; Reumatologia, Hospital Valle de Hebron, Barcelona, Spain; Pediatrics, Università Cattolica Sacro Cuore, Rome, Italy; Fourth Department of Pediatrics, Aristotle University of Thessaloniki Papageorgiou Hospital, Thessaloniki, Greece; Universitatsklinik fur Kinderheilkunde und Jugendmedizin, Tübingen, Germany; Université Paris-Descartes, Hôpital Necker-Enfants Malades, Centre de référence national pour les Arthrites Juveniles, Unité d’Immunologie, Hématologie et Rhumatologie Pédiatrique, Université Descartes, Sorbonne Paris Cité, Institut IMAGINE, Paris, France; National Amyloidosis Centre, University College London Medical School, Royal Free Campus, London, UK. The Eurofever registry was sponsored by the Autoinflammatory Diseases’ Working Group of the Paediatric Rheumatology European Society and supported by the Executive Agency For Health and Consumers (Project No 2007332) and by Coordination Theme 1 (Health) of the European Community’s FP7 (Eurotraps, grant agreement no. HEALTH-F2-2008-200923). Novartis and SOBI have granted unrestricted educational grants. E. Demirkaya, MD, MSc, FAVOR, Gulhane Military Medical Faculty; C. Saglam, MD, FAVOR, Gulhane Military Medical Faculty; T. Turker, MD, Epidemiology, Gulhane Military Medical Faculty; I. Koné-Paut, MD, CEREMAI, Rhumatologie pédiatrique, CHU Le Kremlin Bicêtre (APHP, University of Paris SUD); P. Woo, MD, Center of Paediatric and Adolescent Rheumatology, UCL; M. Doglio, MD, Istituto Giannina Gaslini, UO Pediatria II, Reumatologia; G. Amaryan, MD, PhD, Arabkir Medical Centre, Institute of Child and Adolescents Health; J. Frenkel, MD, Department of Paediatrics, University Medical Center Utrecht; Y. Uziel, MD, MSc, Pediatrics, Meir Medical Centre; A. Insalaco, MD, Division of Rheumatology, Department of Pediatric Medicine, Bambino Gesù Children’s Hospital, IRCCS; L. Cantarini, MD, Rheumatology Unit, Policlinico le Scotte, University of Siena; M. Hofer, MD, PhD, Pediatrie, Centre Multisite Romand de Rhumatologie Pediatrique/CHUV; S. Boiu, MD, Pediatric Rheumatology, Université Paris-Descartes; A. Duzova, MD, Pediatric Rheumatology, Hacettepe University, School of Medicine; C. Modesto, MD, PhD, Reumatologia, Hospital Valle de Hebron; A. Bryant, MD, Center of Paediatric and Adolescent Rheumatology, UCL; D. Rigante, MD, Pediatrics, Università Cattolica Sacro Cuore; E. Papadopoulou-Alataki, MD, PhD, Fourth Department of Pediatrics, Aristotle University of Thessaloniki Papageorgiou Hospital; S. Guillaume-Czitrom, MD, CEREMAI, Rhumatologie pédiatrique, CHU Le Kremlin Bicêtre (APHP, University of Paris SUD); J. Kuemmerle-Deschner, MD, Universitatsklinik fur Kinderheilkunde und Jugendmedizin; B. Neven, MD, Université Paris-Descartes, Hôpital Necker-Enfants Malades, Centre de référence national pour les Arthrites Juveniles, Unité d’Immunologie, Hématologie et Rhumatologie Pédiatrique, Université Descartes, Sorbonne Paris Cité, Institut IMAGINE; H. Lachmann, MD, National Amyloidosis Centre, University College London Medical School, Royal Free Campus; A. Martini, MD, Professor, Istituto Giannina Gaslini, UO Pediatria II, Reumatologia; N. Ruperto, MD, MPH, Istituto Giannina Gaslini, UO Pediatria II, Reumatologia; M. Gattorno, MD, Istituto Giannina Gaslini, UO Pediatria II, Reumatologia; S. Ozen, MD, Pediatric Rheumatology, Hacettepe University, School of Medicine. Dr. Gattorno and Dr. Ozen contributed equally to this manuscript. Address correspondence to Dr. M. Gattorno, UO pediatria II, Istituto G. Gaslini, Largo G. Gaslini 5, 16147, Genoa, Italy. E-mail: marcogattorno@ospedale-gaslini.ge.it. Accepted for publication August 14, 2015.
Consuelo Modesto
From the Familial Mediterranean Fever Arthritis Vasculitis and Orphan Disease Research Center (FAVOR), Gulhane Military Medical Faculty; Epidemiology, Gulhane Military Medical Faculty, Ankara, Turkey; Centre de référence national des maladies auto-inflammatoires, CEREMAI, Rhumatologie pédiatrique, CHU Le Kremlin Bicêtre (APHP, University of Paris SUD), Paris, France; Center of Paediatric and Adolescent Rheumatology, UCL, London, UK; Istituto Giannina Gaslini, UO Pediatria II, Reumatologia, Genoa, Italy; Arabkir Medical Centre, Institute of Child and Adolescents Health, Yerevan, Armenia; Department of Paediatrics, University Medical Center Utrecht, Utrecht, Netherlands; Pediatrics, Meir Medical Centre, Kfar Saba, Israel; Division of Rheumatology, Department of Pediatric Medicine, Bambino Gesù Children’s Hospital, IRCCS, Rome; Rheumatology Unit, Policlinico le Scotte, University of Siena, Siena, Italy; Pediatrie, Centre Multisite Romand de Rhumatologie Pediatrique/Centre Hospitalier, Universitaire Vaudois (CHUV), Lausanne, Switzerland; Pediatric Rheumatology, Université Paris-Descartes, Paris, France; Pediatric Rheumatology, Hacettepe University, School of Medicine, Ankara, Turkey; Reumatologia, Hospital Valle de Hebron, Barcelona, Spain; Pediatrics, Università Cattolica Sacro Cuore, Rome, Italy; Fourth Department of Pediatrics, Aristotle University of Thessaloniki Papageorgiou Hospital, Thessaloniki, Greece; Universitatsklinik fur Kinderheilkunde und Jugendmedizin, Tübingen, Germany; Université Paris-Descartes, Hôpital Necker-Enfants Malades, Centre de référence national pour les Arthrites Juveniles, Unité d’Immunologie, Hématologie et Rhumatologie Pédiatrique, Université Descartes, Sorbonne Paris Cité, Institut IMAGINE, Paris, France; National Amyloidosis Centre, University College London Medical School, Royal Free Campus, London, UK. The Eurofever registry was sponsored by the Autoinflammatory Diseases’ Working Group of the Paediatric Rheumatology European Society and supported by the Executive Agency For Health and Consumers (Project No 2007332) and by Coordination Theme 1 (Health) of the European Community’s FP7 (Eurotraps, grant agreement no. HEALTH-F2-2008-200923). Novartis and SOBI have granted unrestricted educational grants. E. Demirkaya, MD, MSc, FAVOR, Gulhane Military Medical Faculty; C. Saglam, MD, FAVOR, Gulhane Military Medical Faculty; T. Turker, MD, Epidemiology, Gulhane Military Medical Faculty; I. Koné-Paut, MD, CEREMAI, Rhumatologie pédiatrique, CHU Le Kremlin Bicêtre (APHP, University of Paris SUD); P. Woo, MD, Center of Paediatric and Adolescent Rheumatology, UCL; M. Doglio, MD, Istituto Giannina Gaslini, UO Pediatria II, Reumatologia; G. Amaryan, MD, PhD, Arabkir Medical Centre, Institute of Child and Adolescents Health; J. Frenkel, MD, Department of Paediatrics, University Medical Center Utrecht; Y. Uziel, MD, MSc, Pediatrics, Meir Medical Centre; A. Insalaco, MD, Division of Rheumatology, Department of Pediatric Medicine, Bambino Gesù Children’s Hospital, IRCCS; L. Cantarini, MD, Rheumatology Unit, Policlinico le Scotte, University of Siena; M. Hofer, MD, PhD, Pediatrie, Centre Multisite Romand de Rhumatologie Pediatrique/CHUV; S. Boiu, MD, Pediatric Rheumatology, Université Paris-Descartes; A. Duzova, MD, Pediatric Rheumatology, Hacettepe University, School of Medicine; C. Modesto, MD, PhD, Reumatologia, Hospital Valle de Hebron; A. Bryant, MD, Center of Paediatric and Adolescent Rheumatology, UCL; D. Rigante, MD, Pediatrics, Università Cattolica Sacro Cuore; E. Papadopoulou-Alataki, MD, PhD, Fourth Department of Pediatrics, Aristotle University of Thessaloniki Papageorgiou Hospital; S. Guillaume-Czitrom, MD, CEREMAI, Rhumatologie pédiatrique, CHU Le Kremlin Bicêtre (APHP, University of Paris SUD); J. Kuemmerle-Deschner, MD, Universitatsklinik fur Kinderheilkunde und Jugendmedizin; B. Neven, MD, Université Paris-Descartes, Hôpital Necker-Enfants Malades, Centre de référence national pour les Arthrites Juveniles, Unité d’Immunologie, Hématologie et Rhumatologie Pédiatrique, Université Descartes, Sorbonne Paris Cité, Institut IMAGINE; H. Lachmann, MD, National Amyloidosis Centre, University College London Medical School, Royal Free Campus; A. Martini, MD, Professor, Istituto Giannina Gaslini, UO Pediatria II, Reumatologia; N. Ruperto, MD, MPH, Istituto Giannina Gaslini, UO Pediatria II, Reumatologia; M. Gattorno, MD, Istituto Giannina Gaslini, UO Pediatria II, Reumatologia; S. Ozen, MD, Pediatric Rheumatology, Hacettepe University, School of Medicine. Dr. Gattorno and Dr. Ozen contributed equally to this manuscript. Address correspondence to Dr. M. Gattorno, UO pediatria II, Istituto G. Gaslini, Largo G. Gaslini 5, 16147, Genoa, Italy. E-mail: marcogattorno@ospedale-gaslini.ge.it. Accepted for publication August 14, 2015.
Annette Bryant
From the Familial Mediterranean Fever Arthritis Vasculitis and Orphan Disease Research Center (FAVOR), Gulhane Military Medical Faculty; Epidemiology, Gulhane Military Medical Faculty, Ankara, Turkey; Centre de référence national des maladies auto-inflammatoires, CEREMAI, Rhumatologie pédiatrique, CHU Le Kremlin Bicêtre (APHP, University of Paris SUD), Paris, France; Center of Paediatric and Adolescent Rheumatology, UCL, London, UK; Istituto Giannina Gaslini, UO Pediatria II, Reumatologia, Genoa, Italy; Arabkir Medical Centre, Institute of Child and Adolescents Health, Yerevan, Armenia; Department of Paediatrics, University Medical Center Utrecht, Utrecht, Netherlands; Pediatrics, Meir Medical Centre, Kfar Saba, Israel; Division of Rheumatology, Department of Pediatric Medicine, Bambino Gesù Children’s Hospital, IRCCS, Rome; Rheumatology Unit, Policlinico le Scotte, University of Siena, Siena, Italy; Pediatrie, Centre Multisite Romand de Rhumatologie Pediatrique/Centre Hospitalier, Universitaire Vaudois (CHUV), Lausanne, Switzerland; Pediatric Rheumatology, Université Paris-Descartes, Paris, France; Pediatric Rheumatology, Hacettepe University, School of Medicine, Ankara, Turkey; Reumatologia, Hospital Valle de Hebron, Barcelona, Spain; Pediatrics, Università Cattolica Sacro Cuore, Rome, Italy; Fourth Department of Pediatrics, Aristotle University of Thessaloniki Papageorgiou Hospital, Thessaloniki, Greece; Universitatsklinik fur Kinderheilkunde und Jugendmedizin, Tübingen, Germany; Université Paris-Descartes, Hôpital Necker-Enfants Malades, Centre de référence national pour les Arthrites Juveniles, Unité d’Immunologie, Hématologie et Rhumatologie Pédiatrique, Université Descartes, Sorbonne Paris Cité, Institut IMAGINE, Paris, France; National Amyloidosis Centre, University College London Medical School, Royal Free Campus, London, UK. The Eurofever registry was sponsored by the Autoinflammatory Diseases’ Working Group of the Paediatric Rheumatology European Society and supported by the Executive Agency For Health and Consumers (Project No 2007332) and by Coordination Theme 1 (Health) of the European Community’s FP7 (Eurotraps, grant agreement no. HEALTH-F2-2008-200923). Novartis and SOBI have granted unrestricted educational grants. E. Demirkaya, MD, MSc, FAVOR, Gulhane Military Medical Faculty; C. Saglam, MD, FAVOR, Gulhane Military Medical Faculty; T. Turker, MD, Epidemiology, Gulhane Military Medical Faculty; I. Koné-Paut, MD, CEREMAI, Rhumatologie pédiatrique, CHU Le Kremlin Bicêtre (APHP, University of Paris SUD); P. Woo, MD, Center of Paediatric and Adolescent Rheumatology, UCL; M. Doglio, MD, Istituto Giannina Gaslini, UO Pediatria II, Reumatologia; G. Amaryan, MD, PhD, Arabkir Medical Centre, Institute of Child and Adolescents Health; J. Frenkel, MD, Department of Paediatrics, University Medical Center Utrecht; Y. Uziel, MD, MSc, Pediatrics, Meir Medical Centre; A. Insalaco, MD, Division of Rheumatology, Department of Pediatric Medicine, Bambino Gesù Children’s Hospital, IRCCS; L. Cantarini, MD, Rheumatology Unit, Policlinico le Scotte, University of Siena; M. Hofer, MD, PhD, Pediatrie, Centre Multisite Romand de Rhumatologie Pediatrique/CHUV; S. Boiu, MD, Pediatric Rheumatology, Université Paris-Descartes; A. Duzova, MD, Pediatric Rheumatology, Hacettepe University, School of Medicine; C. Modesto, MD, PhD, Reumatologia, Hospital Valle de Hebron; A. Bryant, MD, Center of Paediatric and Adolescent Rheumatology, UCL; D. Rigante, MD, Pediatrics, Università Cattolica Sacro Cuore; E. Papadopoulou-Alataki, MD, PhD, Fourth Department of Pediatrics, Aristotle University of Thessaloniki Papageorgiou Hospital; S. Guillaume-Czitrom, MD, CEREMAI, Rhumatologie pédiatrique, CHU Le Kremlin Bicêtre (APHP, University of Paris SUD); J. Kuemmerle-Deschner, MD, Universitatsklinik fur Kinderheilkunde und Jugendmedizin; B. Neven, MD, Université Paris-Descartes, Hôpital Necker-Enfants Malades, Centre de référence national pour les Arthrites Juveniles, Unité d’Immunologie, Hématologie et Rhumatologie Pédiatrique, Université Descartes, Sorbonne Paris Cité, Institut IMAGINE; H. Lachmann, MD, National Amyloidosis Centre, University College London Medical School, Royal Free Campus; A. Martini, MD, Professor, Istituto Giannina Gaslini, UO Pediatria II, Reumatologia; N. Ruperto, MD, MPH, Istituto Giannina Gaslini, UO Pediatria II, Reumatologia; M. Gattorno, MD, Istituto Giannina Gaslini, UO Pediatria II, Reumatologia; S. Ozen, MD, Pediatric Rheumatology, Hacettepe University, School of Medicine. Dr. Gattorno and Dr. Ozen contributed equally to this manuscript. Address correspondence to Dr. M. Gattorno, UO pediatria II, Istituto G. Gaslini, Largo G. Gaslini 5, 16147, Genoa, Italy. E-mail: marcogattorno@ospedale-gaslini.ge.it. Accepted for publication August 14, 2015.
Donato Rigante
From the Familial Mediterranean Fever Arthritis Vasculitis and Orphan Disease Research Center (FAVOR), Gulhane Military Medical Faculty; Epidemiology, Gulhane Military Medical Faculty, Ankara, Turkey; Centre de référence national des maladies auto-inflammatoires, CEREMAI, Rhumatologie pédiatrique, CHU Le Kremlin Bicêtre (APHP, University of Paris SUD), Paris, France; Center of Paediatric and Adolescent Rheumatology, UCL, London, UK; Istituto Giannina Gaslini, UO Pediatria II, Reumatologia, Genoa, Italy; Arabkir Medical Centre, Institute of Child and Adolescents Health, Yerevan, Armenia; Department of Paediatrics, University Medical Center Utrecht, Utrecht, Netherlands; Pediatrics, Meir Medical Centre, Kfar Saba, Israel; Division of Rheumatology, Department of Pediatric Medicine, Bambino Gesù Children’s Hospital, IRCCS, Rome; Rheumatology Unit, Policlinico le Scotte, University of Siena, Siena, Italy; Pediatrie, Centre Multisite Romand de Rhumatologie Pediatrique/Centre Hospitalier, Universitaire Vaudois (CHUV), Lausanne, Switzerland; Pediatric Rheumatology, Université Paris-Descartes, Paris, France; Pediatric Rheumatology, Hacettepe University, School of Medicine, Ankara, Turkey; Reumatologia, Hospital Valle de Hebron, Barcelona, Spain; Pediatrics, Università Cattolica Sacro Cuore, Rome, Italy; Fourth Department of Pediatrics, Aristotle University of Thessaloniki Papageorgiou Hospital, Thessaloniki, Greece; Universitatsklinik fur Kinderheilkunde und Jugendmedizin, Tübingen, Germany; Université Paris-Descartes, Hôpital Necker-Enfants Malades, Centre de référence national pour les Arthrites Juveniles, Unité d’Immunologie, Hématologie et Rhumatologie Pédiatrique, Université Descartes, Sorbonne Paris Cité, Institut IMAGINE, Paris, France; National Amyloidosis Centre, University College London Medical School, Royal Free Campus, London, UK. The Eurofever registry was sponsored by the Autoinflammatory Diseases’ Working Group of the Paediatric Rheumatology European Society and supported by the Executive Agency For Health and Consumers (Project No 2007332) and by Coordination Theme 1 (Health) of the European Community’s FP7 (Eurotraps, grant agreement no. HEALTH-F2-2008-200923). Novartis and SOBI have granted unrestricted educational grants. E. Demirkaya, MD, MSc, FAVOR, Gulhane Military Medical Faculty; C. Saglam, MD, FAVOR, Gulhane Military Medical Faculty; T. Turker, MD, Epidemiology, Gulhane Military Medical Faculty; I. Koné-Paut, MD, CEREMAI, Rhumatologie pédiatrique, CHU Le Kremlin Bicêtre (APHP, University of Paris SUD); P. Woo, MD, Center of Paediatric and Adolescent Rheumatology, UCL; M. Doglio, MD, Istituto Giannina Gaslini, UO Pediatria II, Reumatologia; G. Amaryan, MD, PhD, Arabkir Medical Centre, Institute of Child and Adolescents Health; J. Frenkel, MD, Department of Paediatrics, University Medical Center Utrecht; Y. Uziel, MD, MSc, Pediatrics, Meir Medical Centre; A. Insalaco, MD, Division of Rheumatology, Department of Pediatric Medicine, Bambino Gesù Children’s Hospital, IRCCS; L. Cantarini, MD, Rheumatology Unit, Policlinico le Scotte, University of Siena; M. Hofer, MD, PhD, Pediatrie, Centre Multisite Romand de Rhumatologie Pediatrique/CHUV; S. Boiu, MD, Pediatric Rheumatology, Université Paris-Descartes; A. Duzova, MD, Pediatric Rheumatology, Hacettepe University, School of Medicine; C. Modesto, MD, PhD, Reumatologia, Hospital Valle de Hebron; A. Bryant, MD, Center of Paediatric and Adolescent Rheumatology, UCL; D. Rigante, MD, Pediatrics, Università Cattolica Sacro Cuore; E. Papadopoulou-Alataki, MD, PhD, Fourth Department of Pediatrics, Aristotle University of Thessaloniki Papageorgiou Hospital; S. Guillaume-Czitrom, MD, CEREMAI, Rhumatologie pédiatrique, CHU Le Kremlin Bicêtre (APHP, University of Paris SUD); J. Kuemmerle-Deschner, MD, Universitatsklinik fur Kinderheilkunde und Jugendmedizin; B. Neven, MD, Université Paris-Descartes, Hôpital Necker-Enfants Malades, Centre de référence national pour les Arthrites Juveniles, Unité d’Immunologie, Hématologie et Rhumatologie Pédiatrique, Université Descartes, Sorbonne Paris Cité, Institut IMAGINE; H. Lachmann, MD, National Amyloidosis Centre, University College London Medical School, Royal Free Campus; A. Martini, MD, Professor, Istituto Giannina Gaslini, UO Pediatria II, Reumatologia; N. Ruperto, MD, MPH, Istituto Giannina Gaslini, UO Pediatria II, Reumatologia; M. Gattorno, MD, Istituto Giannina Gaslini, UO Pediatria II, Reumatologia; S. Ozen, MD, Pediatric Rheumatology, Hacettepe University, School of Medicine. Dr. Gattorno and Dr. Ozen contributed equally to this manuscript. Address correspondence to Dr. M. Gattorno, UO pediatria II, Istituto G. Gaslini, Largo G. Gaslini 5, 16147, Genoa, Italy. E-mail: marcogattorno@ospedale-gaslini.ge.it. Accepted for publication August 14, 2015.
Efimia Papadopoulou-Alataki
From the Familial Mediterranean Fever Arthritis Vasculitis and Orphan Disease Research Center (FAVOR), Gulhane Military Medical Faculty; Epidemiology, Gulhane Military Medical Faculty, Ankara, Turkey; Centre de référence national des maladies auto-inflammatoires, CEREMAI, Rhumatologie pédiatrique, CHU Le Kremlin Bicêtre (APHP, University of Paris SUD), Paris, France; Center of Paediatric and Adolescent Rheumatology, UCL, London, UK; Istituto Giannina Gaslini, UO Pediatria II, Reumatologia, Genoa, Italy; Arabkir Medical Centre, Institute of Child and Adolescents Health, Yerevan, Armenia; Department of Paediatrics, University Medical Center Utrecht, Utrecht, Netherlands; Pediatrics, Meir Medical Centre, Kfar Saba, Israel; Division of Rheumatology, Department of Pediatric Medicine, Bambino Gesù Children’s Hospital, IRCCS, Rome; Rheumatology Unit, Policlinico le Scotte, University of Siena, Siena, Italy; Pediatrie, Centre Multisite Romand de Rhumatologie Pediatrique/Centre Hospitalier, Universitaire Vaudois (CHUV), Lausanne, Switzerland; Pediatric Rheumatology, Université Paris-Descartes, Paris, France; Pediatric Rheumatology, Hacettepe University, School of Medicine, Ankara, Turkey; Reumatologia, Hospital Valle de Hebron, Barcelona, Spain; Pediatrics, Università Cattolica Sacro Cuore, Rome, Italy; Fourth Department of Pediatrics, Aristotle University of Thessaloniki Papageorgiou Hospital, Thessaloniki, Greece; Universitatsklinik fur Kinderheilkunde und Jugendmedizin, Tübingen, Germany; Université Paris-Descartes, Hôpital Necker-Enfants Malades, Centre de référence national pour les Arthrites Juveniles, Unité d’Immunologie, Hématologie et Rhumatologie Pédiatrique, Université Descartes, Sorbonne Paris Cité, Institut IMAGINE, Paris, France; National Amyloidosis Centre, University College London Medical School, Royal Free Campus, London, UK. The Eurofever registry was sponsored by the Autoinflammatory Diseases’ Working Group of the Paediatric Rheumatology European Society and supported by the Executive Agency For Health and Consumers (Project No 2007332) and by Coordination Theme 1 (Health) of the European Community’s FP7 (Eurotraps, grant agreement no. HEALTH-F2-2008-200923). Novartis and SOBI have granted unrestricted educational grants. E. Demirkaya, MD, MSc, FAVOR, Gulhane Military Medical Faculty; C. Saglam, MD, FAVOR, Gulhane Military Medical Faculty; T. Turker, MD, Epidemiology, Gulhane Military Medical Faculty; I. Koné-Paut, MD, CEREMAI, Rhumatologie pédiatrique, CHU Le Kremlin Bicêtre (APHP, University of Paris SUD); P. Woo, MD, Center of Paediatric and Adolescent Rheumatology, UCL; M. Doglio, MD, Istituto Giannina Gaslini, UO Pediatria II, Reumatologia; G. Amaryan, MD, PhD, Arabkir Medical Centre, Institute of Child and Adolescents Health; J. Frenkel, MD, Department of Paediatrics, University Medical Center Utrecht; Y. Uziel, MD, MSc, Pediatrics, Meir Medical Centre; A. Insalaco, MD, Division of Rheumatology, Department of Pediatric Medicine, Bambino Gesù Children’s Hospital, IRCCS; L. Cantarini, MD, Rheumatology Unit, Policlinico le Scotte, University of Siena; M. Hofer, MD, PhD, Pediatrie, Centre Multisite Romand de Rhumatologie Pediatrique/CHUV; S. Boiu, MD, Pediatric Rheumatology, Université Paris-Descartes; A. Duzova, MD, Pediatric Rheumatology, Hacettepe University, School of Medicine; C. Modesto, MD, PhD, Reumatologia, Hospital Valle de Hebron; A. Bryant, MD, Center of Paediatric and Adolescent Rheumatology, UCL; D. Rigante, MD, Pediatrics, Università Cattolica Sacro Cuore; E. Papadopoulou-Alataki, MD, PhD, Fourth Department of Pediatrics, Aristotle University of Thessaloniki Papageorgiou Hospital; S. Guillaume-Czitrom, MD, CEREMAI, Rhumatologie pédiatrique, CHU Le Kremlin Bicêtre (APHP, University of Paris SUD); J. Kuemmerle-Deschner, MD, Universitatsklinik fur Kinderheilkunde und Jugendmedizin; B. Neven, MD, Université Paris-Descartes, Hôpital Necker-Enfants Malades, Centre de référence national pour les Arthrites Juveniles, Unité d’Immunologie, Hématologie et Rhumatologie Pédiatrique, Université Descartes, Sorbonne Paris Cité, Institut IMAGINE; H. Lachmann, MD, National Amyloidosis Centre, University College London Medical School, Royal Free Campus; A. Martini, MD, Professor, Istituto Giannina Gaslini, UO Pediatria II, Reumatologia; N. Ruperto, MD, MPH, Istituto Giannina Gaslini, UO Pediatria II, Reumatologia; M. Gattorno, MD, Istituto Giannina Gaslini, UO Pediatria II, Reumatologia; S. Ozen, MD, Pediatric Rheumatology, Hacettepe University, School of Medicine. Dr. Gattorno and Dr. Ozen contributed equally to this manuscript. Address correspondence to Dr. M. Gattorno, UO pediatria II, Istituto G. Gaslini, Largo G. Gaslini 5, 16147, Genoa, Italy. E-mail: marcogattorno@ospedale-gaslini.ge.it. Accepted for publication August 14, 2015.
Severine Guillaume-Czitrom
From the Familial Mediterranean Fever Arthritis Vasculitis and Orphan Disease Research Center (FAVOR), Gulhane Military Medical Faculty; Epidemiology, Gulhane Military Medical Faculty, Ankara, Turkey; Centre de référence national des maladies auto-inflammatoires, CEREMAI, Rhumatologie pédiatrique, CHU Le Kremlin Bicêtre (APHP, University of Paris SUD), Paris, France; Center of Paediatric and Adolescent Rheumatology, UCL, London, UK; Istituto Giannina Gaslini, UO Pediatria II, Reumatologia, Genoa, Italy; Arabkir Medical Centre, Institute of Child and Adolescents Health, Yerevan, Armenia; Department of Paediatrics, University Medical Center Utrecht, Utrecht, Netherlands; Pediatrics, Meir Medical Centre, Kfar Saba, Israel; Division of Rheumatology, Department of Pediatric Medicine, Bambino Gesù Children’s Hospital, IRCCS, Rome; Rheumatology Unit, Policlinico le Scotte, University of Siena, Siena, Italy; Pediatrie, Centre Multisite Romand de Rhumatologie Pediatrique/Centre Hospitalier, Universitaire Vaudois (CHUV), Lausanne, Switzerland; Pediatric Rheumatology, Université Paris-Descartes, Paris, France; Pediatric Rheumatology, Hacettepe University, School of Medicine, Ankara, Turkey; Reumatologia, Hospital Valle de Hebron, Barcelona, Spain; Pediatrics, Università Cattolica Sacro Cuore, Rome, Italy; Fourth Department of Pediatrics, Aristotle University of Thessaloniki Papageorgiou Hospital, Thessaloniki, Greece; Universitatsklinik fur Kinderheilkunde und Jugendmedizin, Tübingen, Germany; Université Paris-Descartes, Hôpital Necker-Enfants Malades, Centre de référence national pour les Arthrites Juveniles, Unité d’Immunologie, Hématologie et Rhumatologie Pédiatrique, Université Descartes, Sorbonne Paris Cité, Institut IMAGINE, Paris, France; National Amyloidosis Centre, University College London Medical School, Royal Free Campus, London, UK. The Eurofever registry was sponsored by the Autoinflammatory Diseases’ Working Group of the Paediatric Rheumatology European Society and supported by the Executive Agency For Health and Consumers (Project No 2007332) and by Coordination Theme 1 (Health) of the European Community’s FP7 (Eurotraps, grant agreement no. HEALTH-F2-2008-200923). Novartis and SOBI have granted unrestricted educational grants. E. Demirkaya, MD, MSc, FAVOR, Gulhane Military Medical Faculty; C. Saglam, MD, FAVOR, Gulhane Military Medical Faculty; T. Turker, MD, Epidemiology, Gulhane Military Medical Faculty; I. Koné-Paut, MD, CEREMAI, Rhumatologie pédiatrique, CHU Le Kremlin Bicêtre (APHP, University of Paris SUD); P. Woo, MD, Center of Paediatric and Adolescent Rheumatology, UCL; M. Doglio, MD, Istituto Giannina Gaslini, UO Pediatria II, Reumatologia; G. Amaryan, MD, PhD, Arabkir Medical Centre, Institute of Child and Adolescents Health; J. Frenkel, MD, Department of Paediatrics, University Medical Center Utrecht; Y. Uziel, MD, MSc, Pediatrics, Meir Medical Centre; A. Insalaco, MD, Division of Rheumatology, Department of Pediatric Medicine, Bambino Gesù Children’s Hospital, IRCCS; L. Cantarini, MD, Rheumatology Unit, Policlinico le Scotte, University of Siena; M. Hofer, MD, PhD, Pediatrie, Centre Multisite Romand de Rhumatologie Pediatrique/CHUV; S. Boiu, MD, Pediatric Rheumatology, Université Paris-Descartes; A. Duzova, MD, Pediatric Rheumatology, Hacettepe University, School of Medicine; C. Modesto, MD, PhD, Reumatologia, Hospital Valle de Hebron; A. Bryant, MD, Center of Paediatric and Adolescent Rheumatology, UCL; D. Rigante, MD, Pediatrics, Università Cattolica Sacro Cuore; E. Papadopoulou-Alataki, MD, PhD, Fourth Department of Pediatrics, Aristotle University of Thessaloniki Papageorgiou Hospital; S. Guillaume-Czitrom, MD, CEREMAI, Rhumatologie pédiatrique, CHU Le Kremlin Bicêtre (APHP, University of Paris SUD); J. Kuemmerle-Deschner, MD, Universitatsklinik fur Kinderheilkunde und Jugendmedizin; B. Neven, MD, Université Paris-Descartes, Hôpital Necker-Enfants Malades, Centre de référence national pour les Arthrites Juveniles, Unité d’Immunologie, Hématologie et Rhumatologie Pédiatrique, Université Descartes, Sorbonne Paris Cité, Institut IMAGINE; H. Lachmann, MD, National Amyloidosis Centre, University College London Medical School, Royal Free Campus; A. Martini, MD, Professor, Istituto Giannina Gaslini, UO Pediatria II, Reumatologia; N. Ruperto, MD, MPH, Istituto Giannina Gaslini, UO Pediatria II, Reumatologia; M. Gattorno, MD, Istituto Giannina Gaslini, UO Pediatria II, Reumatologia; S. Ozen, MD, Pediatric Rheumatology, Hacettepe University, School of Medicine. Dr. Gattorno and Dr. Ozen contributed equally to this manuscript. Address correspondence to Dr. M. Gattorno, UO pediatria II, Istituto G. Gaslini, Largo G. Gaslini 5, 16147, Genoa, Italy. E-mail: marcogattorno@ospedale-gaslini.ge.it. Accepted for publication August 14, 2015.
Jasmine Kuemmerle-Deschner
From the Familial Mediterranean Fever Arthritis Vasculitis and Orphan Disease Research Center (FAVOR), Gulhane Military Medical Faculty; Epidemiology, Gulhane Military Medical Faculty, Ankara, Turkey; Centre de référence national des maladies auto-inflammatoires, CEREMAI, Rhumatologie pédiatrique, CHU Le Kremlin Bicêtre (APHP, University of Paris SUD), Paris, France; Center of Paediatric and Adolescent Rheumatology, UCL, London, UK; Istituto Giannina Gaslini, UO Pediatria II, Reumatologia, Genoa, Italy; Arabkir Medical Centre, Institute of Child and Adolescents Health, Yerevan, Armenia; Department of Paediatrics, University Medical Center Utrecht, Utrecht, Netherlands; Pediatrics, Meir Medical Centre, Kfar Saba, Israel; Division of Rheumatology, Department of Pediatric Medicine, Bambino Gesù Children’s Hospital, IRCCS, Rome; Rheumatology Unit, Policlinico le Scotte, University of Siena, Siena, Italy; Pediatrie, Centre Multisite Romand de Rhumatologie Pediatrique/Centre Hospitalier, Universitaire Vaudois (CHUV), Lausanne, Switzerland; Pediatric Rheumatology, Université Paris-Descartes, Paris, France; Pediatric Rheumatology, Hacettepe University, School of Medicine, Ankara, Turkey; Reumatologia, Hospital Valle de Hebron, Barcelona, Spain; Pediatrics, Università Cattolica Sacro Cuore, Rome, Italy; Fourth Department of Pediatrics, Aristotle University of Thessaloniki Papageorgiou Hospital, Thessaloniki, Greece; Universitatsklinik fur Kinderheilkunde und Jugendmedizin, Tübingen, Germany; Université Paris-Descartes, Hôpital Necker-Enfants Malades, Centre de référence national pour les Arthrites Juveniles, Unité d’Immunologie, Hématologie et Rhumatologie Pédiatrique, Université Descartes, Sorbonne Paris Cité, Institut IMAGINE, Paris, France; National Amyloidosis Centre, University College London Medical School, Royal Free Campus, London, UK. The Eurofever registry was sponsored by the Autoinflammatory Diseases’ Working Group of the Paediatric Rheumatology European Society and supported by the Executive Agency For Health and Consumers (Project No 2007332) and by Coordination Theme 1 (Health) of the European Community’s FP7 (Eurotraps, grant agreement no. HEALTH-F2-2008-200923). Novartis and SOBI have granted unrestricted educational grants. E. Demirkaya, MD, MSc, FAVOR, Gulhane Military Medical Faculty; C. Saglam, MD, FAVOR, Gulhane Military Medical Faculty; T. Turker, MD, Epidemiology, Gulhane Military Medical Faculty; I. Koné-Paut, MD, CEREMAI, Rhumatologie pédiatrique, CHU Le Kremlin Bicêtre (APHP, University of Paris SUD); P. Woo, MD, Center of Paediatric and Adolescent Rheumatology, UCL; M. Doglio, MD, Istituto Giannina Gaslini, UO Pediatria II, Reumatologia; G. Amaryan, MD, PhD, Arabkir Medical Centre, Institute of Child and Adolescents Health; J. Frenkel, MD, Department of Paediatrics, University Medical Center Utrecht; Y. Uziel, MD, MSc, Pediatrics, Meir Medical Centre; A. Insalaco, MD, Division of Rheumatology, Department of Pediatric Medicine, Bambino Gesù Children’s Hospital, IRCCS; L. Cantarini, MD, Rheumatology Unit, Policlinico le Scotte, University of Siena; M. Hofer, MD, PhD, Pediatrie, Centre Multisite Romand de Rhumatologie Pediatrique/CHUV; S. Boiu, MD, Pediatric Rheumatology, Université Paris-Descartes; A. Duzova, MD, Pediatric Rheumatology, Hacettepe University, School of Medicine; C. Modesto, MD, PhD, Reumatologia, Hospital Valle de Hebron; A. Bryant, MD, Center of Paediatric and Adolescent Rheumatology, UCL; D. Rigante, MD, Pediatrics, Università Cattolica Sacro Cuore; E. Papadopoulou-Alataki, MD, PhD, Fourth Department of Pediatrics, Aristotle University of Thessaloniki Papageorgiou Hospital; S. Guillaume-Czitrom, MD, CEREMAI, Rhumatologie pédiatrique, CHU Le Kremlin Bicêtre (APHP, University of Paris SUD); J. Kuemmerle-Deschner, MD, Universitatsklinik fur Kinderheilkunde und Jugendmedizin; B. Neven, MD, Université Paris-Descartes, Hôpital Necker-Enfants Malades, Centre de référence national pour les Arthrites Juveniles, Unité d’Immunologie, Hématologie et Rhumatologie Pédiatrique, Université Descartes, Sorbonne Paris Cité, Institut IMAGINE; H. Lachmann, MD, National Amyloidosis Centre, University College London Medical School, Royal Free Campus; A. Martini, MD, Professor, Istituto Giannina Gaslini, UO Pediatria II, Reumatologia; N. Ruperto, MD, MPH, Istituto Giannina Gaslini, UO Pediatria II, Reumatologia; M. Gattorno, MD, Istituto Giannina Gaslini, UO Pediatria II, Reumatologia; S. Ozen, MD, Pediatric Rheumatology, Hacettepe University, School of Medicine. Dr. Gattorno and Dr. Ozen contributed equally to this manuscript. Address correspondence to Dr. M. Gattorno, UO pediatria II, Istituto G. Gaslini, Largo G. Gaslini 5, 16147, Genoa, Italy. E-mail: marcogattorno@ospedale-gaslini.ge.it. Accepted for publication August 14, 2015.
Bénédicte Neven
From the Familial Mediterranean Fever Arthritis Vasculitis and Orphan Disease Research Center (FAVOR), Gulhane Military Medical Faculty; Epidemiology, Gulhane Military Medical Faculty, Ankara, Turkey; Centre de référence national des maladies auto-inflammatoires, CEREMAI, Rhumatologie pédiatrique, CHU Le Kremlin Bicêtre (APHP, University of Paris SUD), Paris, France; Center of Paediatric and Adolescent Rheumatology, UCL, London, UK; Istituto Giannina Gaslini, UO Pediatria II, Reumatologia, Genoa, Italy; Arabkir Medical Centre, Institute of Child and Adolescents Health, Yerevan, Armenia; Department of Paediatrics, University Medical Center Utrecht, Utrecht, Netherlands; Pediatrics, Meir Medical Centre, Kfar Saba, Israel; Division of Rheumatology, Department of Pediatric Medicine, Bambino Gesù Children’s Hospital, IRCCS, Rome; Rheumatology Unit, Policlinico le Scotte, University of Siena, Siena, Italy; Pediatrie, Centre Multisite Romand de Rhumatologie Pediatrique/Centre Hospitalier, Universitaire Vaudois (CHUV), Lausanne, Switzerland; Pediatric Rheumatology, Université Paris-Descartes, Paris, France; Pediatric Rheumatology, Hacettepe University, School of Medicine, Ankara, Turkey; Reumatologia, Hospital Valle de Hebron, Barcelona, Spain; Pediatrics, Università Cattolica Sacro Cuore, Rome, Italy; Fourth Department of Pediatrics, Aristotle University of Thessaloniki Papageorgiou Hospital, Thessaloniki, Greece; Universitatsklinik fur Kinderheilkunde und Jugendmedizin, Tübingen, Germany; Université Paris-Descartes, Hôpital Necker-Enfants Malades, Centre de référence national pour les Arthrites Juveniles, Unité d’Immunologie, Hématologie et Rhumatologie Pédiatrique, Université Descartes, Sorbonne Paris Cité, Institut IMAGINE, Paris, France; National Amyloidosis Centre, University College London Medical School, Royal Free Campus, London, UK. The Eurofever registry was sponsored by the Autoinflammatory Diseases’ Working Group of the Paediatric Rheumatology European Society and supported by the Executive Agency For Health and Consumers (Project No 2007332) and by Coordination Theme 1 (Health) of the European Community’s FP7 (Eurotraps, grant agreement no. HEALTH-F2-2008-200923). Novartis and SOBI have granted unrestricted educational grants. E. Demirkaya, MD, MSc, FAVOR, Gulhane Military Medical Faculty; C. Saglam, MD, FAVOR, Gulhane Military Medical Faculty; T. Turker, MD, Epidemiology, Gulhane Military Medical Faculty; I. Koné-Paut, MD, CEREMAI, Rhumatologie pédiatrique, CHU Le Kremlin Bicêtre (APHP, University of Paris SUD); P. Woo, MD, Center of Paediatric and Adolescent Rheumatology, UCL; M. Doglio, MD, Istituto Giannina Gaslini, UO Pediatria II, Reumatologia; G. Amaryan, MD, PhD, Arabkir Medical Centre, Institute of Child and Adolescents Health; J. Frenkel, MD, Department of Paediatrics, University Medical Center Utrecht; Y. Uziel, MD, MSc, Pediatrics, Meir Medical Centre; A. Insalaco, MD, Division of Rheumatology, Department of Pediatric Medicine, Bambino Gesù Children’s Hospital, IRCCS; L. Cantarini, MD, Rheumatology Unit, Policlinico le Scotte, University of Siena; M. Hofer, MD, PhD, Pediatrie, Centre Multisite Romand de Rhumatologie Pediatrique/CHUV; S. Boiu, MD, Pediatric Rheumatology, Université Paris-Descartes; A. Duzova, MD, Pediatric Rheumatology, Hacettepe University, School of Medicine; C. Modesto, MD, PhD, Reumatologia, Hospital Valle de Hebron; A. Bryant, MD, Center of Paediatric and Adolescent Rheumatology, UCL; D. Rigante, MD, Pediatrics, Università Cattolica Sacro Cuore; E. Papadopoulou-Alataki, MD, PhD, Fourth Department of Pediatrics, Aristotle University of Thessaloniki Papageorgiou Hospital; S. Guillaume-Czitrom, MD, CEREMAI, Rhumatologie pédiatrique, CHU Le Kremlin Bicêtre (APHP, University of Paris SUD); J. Kuemmerle-Deschner, MD, Universitatsklinik fur Kinderheilkunde und Jugendmedizin; B. Neven, MD, Université Paris-Descartes, Hôpital Necker-Enfants Malades, Centre de référence national pour les Arthrites Juveniles, Unité d’Immunologie, Hématologie et Rhumatologie Pédiatrique, Université Descartes, Sorbonne Paris Cité, Institut IMAGINE; H. Lachmann, MD, National Amyloidosis Centre, University College London Medical School, Royal Free Campus; A. Martini, MD, Professor, Istituto Giannina Gaslini, UO Pediatria II, Reumatologia; N. Ruperto, MD, MPH, Istituto Giannina Gaslini, UO Pediatria II, Reumatologia; M. Gattorno, MD, Istituto Giannina Gaslini, UO Pediatria II, Reumatologia; S. Ozen, MD, Pediatric Rheumatology, Hacettepe University, School of Medicine. Dr. Gattorno and Dr. Ozen contributed equally to this manuscript. Address correspondence to Dr. M. Gattorno, UO pediatria II, Istituto G. Gaslini, Largo G. Gaslini 5, 16147, Genoa, Italy. E-mail: marcogattorno@ospedale-gaslini.ge.it. Accepted for publication August 14, 2015.
Helen Lachmann
From the Familial Mediterranean Fever Arthritis Vasculitis and Orphan Disease Research Center (FAVOR), Gulhane Military Medical Faculty; Epidemiology, Gulhane Military Medical Faculty, Ankara, Turkey; Centre de référence national des maladies auto-inflammatoires, CEREMAI, Rhumatologie pédiatrique, CHU Le Kremlin Bicêtre (APHP, University of Paris SUD), Paris, France; Center of Paediatric and Adolescent Rheumatology, UCL, London, UK; Istituto Giannina Gaslini, UO Pediatria II, Reumatologia, Genoa, Italy; Arabkir Medical Centre, Institute of Child and Adolescents Health, Yerevan, Armenia; Department of Paediatrics, University Medical Center Utrecht, Utrecht, Netherlands; Pediatrics, Meir Medical Centre, Kfar Saba, Israel; Division of Rheumatology, Department of Pediatric Medicine, Bambino Gesù Children’s Hospital, IRCCS, Rome; Rheumatology Unit, Policlinico le Scotte, University of Siena, Siena, Italy; Pediatrie, Centre Multisite Romand de Rhumatologie Pediatrique/Centre Hospitalier, Universitaire Vaudois (CHUV), Lausanne, Switzerland; Pediatric Rheumatology, Université Paris-Descartes, Paris, France; Pediatric Rheumatology, Hacettepe University, School of Medicine, Ankara, Turkey; Reumatologia, Hospital Valle de Hebron, Barcelona, Spain; Pediatrics, Università Cattolica Sacro Cuore, Rome, Italy; Fourth Department of Pediatrics, Aristotle University of Thessaloniki Papageorgiou Hospital, Thessaloniki, Greece; Universitatsklinik fur Kinderheilkunde und Jugendmedizin, Tübingen, Germany; Université Paris-Descartes, Hôpital Necker-Enfants Malades, Centre de référence national pour les Arthrites Juveniles, Unité d’Immunologie, Hématologie et Rhumatologie Pédiatrique, Université Descartes, Sorbonne Paris Cité, Institut IMAGINE, Paris, France; National Amyloidosis Centre, University College London Medical School, Royal Free Campus, London, UK. The Eurofever registry was sponsored by the Autoinflammatory Diseases’ Working Group of the Paediatric Rheumatology European Society and supported by the Executive Agency For Health and Consumers (Project No 2007332) and by Coordination Theme 1 (Health) of the European Community’s FP7 (Eurotraps, grant agreement no. HEALTH-F2-2008-200923). Novartis and SOBI have granted unrestricted educational grants. E. Demirkaya, MD, MSc, FAVOR, Gulhane Military Medical Faculty; C. Saglam, MD, FAVOR, Gulhane Military Medical Faculty; T. Turker, MD, Epidemiology, Gulhane Military Medical Faculty; I. Koné-Paut, MD, CEREMAI, Rhumatologie pédiatrique, CHU Le Kremlin Bicêtre (APHP, University of Paris SUD); P. Woo, MD, Center of Paediatric and Adolescent Rheumatology, UCL; M. Doglio, MD, Istituto Giannina Gaslini, UO Pediatria II, Reumatologia; G. Amaryan, MD, PhD, Arabkir Medical Centre, Institute of Child and Adolescents Health; J. Frenkel, MD, Department of Paediatrics, University Medical Center Utrecht; Y. Uziel, MD, MSc, Pediatrics, Meir Medical Centre; A. Insalaco, MD, Division of Rheumatology, Department of Pediatric Medicine, Bambino Gesù Children’s Hospital, IRCCS; L. Cantarini, MD, Rheumatology Unit, Policlinico le Scotte, University of Siena; M. Hofer, MD, PhD, Pediatrie, Centre Multisite Romand de Rhumatologie Pediatrique/CHUV; S. Boiu, MD, Pediatric Rheumatology, Université Paris-Descartes; A. Duzova, MD, Pediatric Rheumatology, Hacettepe University, School of Medicine; C. Modesto, MD, PhD, Reumatologia, Hospital Valle de Hebron; A. Bryant, MD, Center of Paediatric and Adolescent Rheumatology, UCL; D. Rigante, MD, Pediatrics, Università Cattolica Sacro Cuore; E. Papadopoulou-Alataki, MD, PhD, Fourth Department of Pediatrics, Aristotle University of Thessaloniki Papageorgiou Hospital; S. Guillaume-Czitrom, MD, CEREMAI, Rhumatologie pédiatrique, CHU Le Kremlin Bicêtre (APHP, University of Paris SUD); J. Kuemmerle-Deschner, MD, Universitatsklinik fur Kinderheilkunde und Jugendmedizin; B. Neven, MD, Université Paris-Descartes, Hôpital Necker-Enfants Malades, Centre de référence national pour les Arthrites Juveniles, Unité d’Immunologie, Hématologie et Rhumatologie Pédiatrique, Université Descartes, Sorbonne Paris Cité, Institut IMAGINE; H. Lachmann, MD, National Amyloidosis Centre, University College London Medical School, Royal Free Campus; A. Martini, MD, Professor, Istituto Giannina Gaslini, UO Pediatria II, Reumatologia; N. Ruperto, MD, MPH, Istituto Giannina Gaslini, UO Pediatria II, Reumatologia; M. Gattorno, MD, Istituto Giannina Gaslini, UO Pediatria II, Reumatologia; S. Ozen, MD, Pediatric Rheumatology, Hacettepe University, School of Medicine. Dr. Gattorno and Dr. Ozen contributed equally to this manuscript. Address correspondence to Dr. M. Gattorno, UO pediatria II, Istituto G. Gaslini, Largo G. Gaslini 5, 16147, Genoa, Italy. E-mail: marcogattorno@ospedale-gaslini.ge.it. Accepted for publication August 14, 2015.
Alberto Martini
From the Familial Mediterranean Fever Arthritis Vasculitis and Orphan Disease Research Center (FAVOR), Gulhane Military Medical Faculty; Epidemiology, Gulhane Military Medical Faculty, Ankara, Turkey; Centre de référence national des maladies auto-inflammatoires, CEREMAI, Rhumatologie pédiatrique, CHU Le Kremlin Bicêtre (APHP, University of Paris SUD), Paris, France; Center of Paediatric and Adolescent Rheumatology, UCL, London, UK; Istituto Giannina Gaslini, UO Pediatria II, Reumatologia, Genoa, Italy; Arabkir Medical Centre, Institute of Child and Adolescents Health, Yerevan, Armenia; Department of Paediatrics, University Medical Center Utrecht, Utrecht, Netherlands; Pediatrics, Meir Medical Centre, Kfar Saba, Israel; Division of Rheumatology, Department of Pediatric Medicine, Bambino Gesù Children’s Hospital, IRCCS, Rome; Rheumatology Unit, Policlinico le Scotte, University of Siena, Siena, Italy; Pediatrie, Centre Multisite Romand de Rhumatologie Pediatrique/Centre Hospitalier, Universitaire Vaudois (CHUV), Lausanne, Switzerland; Pediatric Rheumatology, Université Paris-Descartes, Paris, France; Pediatric Rheumatology, Hacettepe University, School of Medicine, Ankara, Turkey; Reumatologia, Hospital Valle de Hebron, Barcelona, Spain; Pediatrics, Università Cattolica Sacro Cuore, Rome, Italy; Fourth Department of Pediatrics, Aristotle University of Thessaloniki Papageorgiou Hospital, Thessaloniki, Greece; Universitatsklinik fur Kinderheilkunde und Jugendmedizin, Tübingen, Germany; Université Paris-Descartes, Hôpital Necker-Enfants Malades, Centre de référence national pour les Arthrites Juveniles, Unité d’Immunologie, Hématologie et Rhumatologie Pédiatrique, Université Descartes, Sorbonne Paris Cité, Institut IMAGINE, Paris, France; National Amyloidosis Centre, University College London Medical School, Royal Free Campus, London, UK. The Eurofever registry was sponsored by the Autoinflammatory Diseases’ Working Group of the Paediatric Rheumatology European Society and supported by the Executive Agency For Health and Consumers (Project No 2007332) and by Coordination Theme 1 (Health) of the European Community’s FP7 (Eurotraps, grant agreement no. HEALTH-F2-2008-200923). Novartis and SOBI have granted unrestricted educational grants. E. Demirkaya, MD, MSc, FAVOR, Gulhane Military Medical Faculty; C. Saglam, MD, FAVOR, Gulhane Military Medical Faculty; T. Turker, MD, Epidemiology, Gulhane Military Medical Faculty; I. Koné-Paut, MD, CEREMAI, Rhumatologie pédiatrique, CHU Le Kremlin Bicêtre (APHP, University of Paris SUD); P. Woo, MD, Center of Paediatric and Adolescent Rheumatology, UCL; M. Doglio, MD, Istituto Giannina Gaslini, UO Pediatria II, Reumatologia; G. Amaryan, MD, PhD, Arabkir Medical Centre, Institute of Child and Adolescents Health; J. Frenkel, MD, Department of Paediatrics, University Medical Center Utrecht; Y. Uziel, MD, MSc, Pediatrics, Meir Medical Centre; A. Insalaco, MD, Division of Rheumatology, Department of Pediatric Medicine, Bambino Gesù Children’s Hospital, IRCCS; L. Cantarini, MD, Rheumatology Unit, Policlinico le Scotte, University of Siena; M. Hofer, MD, PhD, Pediatrie, Centre Multisite Romand de Rhumatologie Pediatrique/CHUV; S. Boiu, MD, Pediatric Rheumatology, Université Paris-Descartes; A. Duzova, MD, Pediatric Rheumatology, Hacettepe University, School of Medicine; C. Modesto, MD, PhD, Reumatologia, Hospital Valle de Hebron; A. Bryant, MD, Center of Paediatric and Adolescent Rheumatology, UCL; D. Rigante, MD, Pediatrics, Università Cattolica Sacro Cuore; E. Papadopoulou-Alataki, MD, PhD, Fourth Department of Pediatrics, Aristotle University of Thessaloniki Papageorgiou Hospital; S. Guillaume-Czitrom, MD, CEREMAI, Rhumatologie pédiatrique, CHU Le Kremlin Bicêtre (APHP, University of Paris SUD); J. Kuemmerle-Deschner, MD, Universitatsklinik fur Kinderheilkunde und Jugendmedizin; B. Neven, MD, Université Paris-Descartes, Hôpital Necker-Enfants Malades, Centre de référence national pour les Arthrites Juveniles, Unité d’Immunologie, Hématologie et Rhumatologie Pédiatrique, Université Descartes, Sorbonne Paris Cité, Institut IMAGINE; H. Lachmann, MD, National Amyloidosis Centre, University College London Medical School, Royal Free Campus; A. Martini, MD, Professor, Istituto Giannina Gaslini, UO Pediatria II, Reumatologia; N. Ruperto, MD, MPH, Istituto Giannina Gaslini, UO Pediatria II, Reumatologia; M. Gattorno, MD, Istituto Giannina Gaslini, UO Pediatria II, Reumatologia; S. Ozen, MD, Pediatric Rheumatology, Hacettepe University, School of Medicine. Dr. Gattorno and Dr. Ozen contributed equally to this manuscript. Address correspondence to Dr. M. Gattorno, UO pediatria II, Istituto G. Gaslini, Largo G. Gaslini 5, 16147, Genoa, Italy. E-mail: marcogattorno@ospedale-gaslini.ge.it. Accepted for publication August 14, 2015.
Nicolino Ruperto
From the Familial Mediterranean Fever Arthritis Vasculitis and Orphan Disease Research Center (FAVOR), Gulhane Military Medical Faculty; Epidemiology, Gulhane Military Medical Faculty, Ankara, Turkey; Centre de référence national des maladies auto-inflammatoires, CEREMAI, Rhumatologie pédiatrique, CHU Le Kremlin Bicêtre (APHP, University of Paris SUD), Paris, France; Center of Paediatric and Adolescent Rheumatology, UCL, London, UK; Istituto Giannina Gaslini, UO Pediatria II, Reumatologia, Genoa, Italy; Arabkir Medical Centre, Institute of Child and Adolescents Health, Yerevan, Armenia; Department of Paediatrics, University Medical Center Utrecht, Utrecht, Netherlands; Pediatrics, Meir Medical Centre, Kfar Saba, Israel; Division of Rheumatology, Department of Pediatric Medicine, Bambino Gesù Children’s Hospital, IRCCS, Rome; Rheumatology Unit, Policlinico le Scotte, University of Siena, Siena, Italy; Pediatrie, Centre Multisite Romand de Rhumatologie Pediatrique/Centre Hospitalier, Universitaire Vaudois (CHUV), Lausanne, Switzerland; Pediatric Rheumatology, Université Paris-Descartes, Paris, France; Pediatric Rheumatology, Hacettepe University, School of Medicine, Ankara, Turkey; Reumatologia, Hospital Valle de Hebron, Barcelona, Spain; Pediatrics, Università Cattolica Sacro Cuore, Rome, Italy; Fourth Department of Pediatrics, Aristotle University of Thessaloniki Papageorgiou Hospital, Thessaloniki, Greece; Universitatsklinik fur Kinderheilkunde und Jugendmedizin, Tübingen, Germany; Université Paris-Descartes, Hôpital Necker-Enfants Malades, Centre de référence national pour les Arthrites Juveniles, Unité d’Immunologie, Hématologie et Rhumatologie Pédiatrique, Université Descartes, Sorbonne Paris Cité, Institut IMAGINE, Paris, France; National Amyloidosis Centre, University College London Medical School, Royal Free Campus, London, UK. The Eurofever registry was sponsored by the Autoinflammatory Diseases’ Working Group of the Paediatric Rheumatology European Society and supported by the Executive Agency For Health and Consumers (Project No 2007332) and by Coordination Theme 1 (Health) of the European Community’s FP7 (Eurotraps, grant agreement no. HEALTH-F2-2008-200923). Novartis and SOBI have granted unrestricted educational grants. E. Demirkaya, MD, MSc, FAVOR, Gulhane Military Medical Faculty; C. Saglam, MD, FAVOR, Gulhane Military Medical Faculty; T. Turker, MD, Epidemiology, Gulhane Military Medical Faculty; I. Koné-Paut, MD, CEREMAI, Rhumatologie pédiatrique, CHU Le Kremlin Bicêtre (APHP, University of Paris SUD); P. Woo, MD, Center of Paediatric and Adolescent Rheumatology, UCL; M. Doglio, MD, Istituto Giannina Gaslini, UO Pediatria II, Reumatologia; G. Amaryan, MD, PhD, Arabkir Medical Centre, Institute of Child and Adolescents Health; J. Frenkel, MD, Department of Paediatrics, University Medical Center Utrecht; Y. Uziel, MD, MSc, Pediatrics, Meir Medical Centre; A. Insalaco, MD, Division of Rheumatology, Department of Pediatric Medicine, Bambino Gesù Children’s Hospital, IRCCS; L. Cantarini, MD, Rheumatology Unit, Policlinico le Scotte, University of Siena; M. Hofer, MD, PhD, Pediatrie, Centre Multisite Romand de Rhumatologie Pediatrique/CHUV; S. Boiu, MD, Pediatric Rheumatology, Université Paris-Descartes; A. Duzova, MD, Pediatric Rheumatology, Hacettepe University, School of Medicine; C. Modesto, MD, PhD, Reumatologia, Hospital Valle de Hebron; A. Bryant, MD, Center of Paediatric and Adolescent Rheumatology, UCL; D. Rigante, MD, Pediatrics, Università Cattolica Sacro Cuore; E. Papadopoulou-Alataki, MD, PhD, Fourth Department of Pediatrics, Aristotle University of Thessaloniki Papageorgiou Hospital; S. Guillaume-Czitrom, MD, CEREMAI, Rhumatologie pédiatrique, CHU Le Kremlin Bicêtre (APHP, University of Paris SUD); J. Kuemmerle-Deschner, MD, Universitatsklinik fur Kinderheilkunde und Jugendmedizin; B. Neven, MD, Université Paris-Descartes, Hôpital Necker-Enfants Malades, Centre de référence national pour les Arthrites Juveniles, Unité d’Immunologie, Hématologie et Rhumatologie Pédiatrique, Université Descartes, Sorbonne Paris Cité, Institut IMAGINE; H. Lachmann, MD, National Amyloidosis Centre, University College London Medical School, Royal Free Campus; A. Martini, MD, Professor, Istituto Giannina Gaslini, UO Pediatria II, Reumatologia; N. Ruperto, MD, MPH, Istituto Giannina Gaslini, UO Pediatria II, Reumatologia; M. Gattorno, MD, Istituto Giannina Gaslini, UO Pediatria II, Reumatologia; S. Ozen, MD, Pediatric Rheumatology, Hacettepe University, School of Medicine. Dr. Gattorno and Dr. Ozen contributed equally to this manuscript. Address correspondence to Dr. M. Gattorno, UO pediatria II, Istituto G. Gaslini, Largo G. Gaslini 5, 16147, Genoa, Italy. E-mail: marcogattorno@ospedale-gaslini.ge.it. Accepted for publication August 14, 2015.
Marco Gattorno
From the Familial Mediterranean Fever Arthritis Vasculitis and Orphan Disease Research Center (FAVOR), Gulhane Military Medical Faculty; Epidemiology, Gulhane Military Medical Faculty, Ankara, Turkey; Centre de référence national des maladies auto-inflammatoires, CEREMAI, Rhumatologie pédiatrique, CHU Le Kremlin Bicêtre (APHP, University of Paris SUD), Paris, France; Center of Paediatric and Adolescent Rheumatology, UCL, London, UK; Istituto Giannina Gaslini, UO Pediatria II, Reumatologia, Genoa, Italy; Arabkir Medical Centre, Institute of Child and Adolescents Health, Yerevan, Armenia; Department of Paediatrics, University Medical Center Utrecht, Utrecht, Netherlands; Pediatrics, Meir Medical Centre, Kfar Saba, Israel; Division of Rheumatology, Department of Pediatric Medicine, Bambino Gesù Children’s Hospital, IRCCS, Rome; Rheumatology Unit, Policlinico le Scotte, University of Siena, Siena, Italy; Pediatrie, Centre Multisite Romand de Rhumatologie Pediatrique/Centre Hospitalier, Universitaire Vaudois (CHUV), Lausanne, Switzerland; Pediatric Rheumatology, Université Paris-Descartes, Paris, France; Pediatric Rheumatology, Hacettepe University, School of Medicine, Ankara, Turkey; Reumatologia, Hospital Valle de Hebron, Barcelona, Spain; Pediatrics, Università Cattolica Sacro Cuore, Rome, Italy; Fourth Department of Pediatrics, Aristotle University of Thessaloniki Papageorgiou Hospital, Thessaloniki, Greece; Universitatsklinik fur Kinderheilkunde und Jugendmedizin, Tübingen, Germany; Université Paris-Descartes, Hôpital Necker-Enfants Malades, Centre de référence national pour les Arthrites Juveniles, Unité d’Immunologie, Hématologie et Rhumatologie Pédiatrique, Université Descartes, Sorbonne Paris Cité, Institut IMAGINE, Paris, France; National Amyloidosis Centre, University College London Medical School, Royal Free Campus, London, UK. The Eurofever registry was sponsored by the Autoinflammatory Diseases’ Working Group of the Paediatric Rheumatology European Society and supported by the Executive Agency For Health and Consumers (Project No 2007332) and by Coordination Theme 1 (Health) of the European Community’s FP7 (Eurotraps, grant agreement no. HEALTH-F2-2008-200923). Novartis and SOBI have granted unrestricted educational grants. E. Demirkaya, MD, MSc, FAVOR, Gulhane Military Medical Faculty; C. Saglam, MD, FAVOR, Gulhane Military Medical Faculty; T. Turker, MD, Epidemiology, Gulhane Military Medical Faculty; I. Koné-Paut, MD, CEREMAI, Rhumatologie pédiatrique, CHU Le Kremlin Bicêtre (APHP, University of Paris SUD); P. Woo, MD, Center of Paediatric and Adolescent Rheumatology, UCL; M. Doglio, MD, Istituto Giannina Gaslini, UO Pediatria II, Reumatologia; G. Amaryan, MD, PhD, Arabkir Medical Centre, Institute of Child and Adolescents Health; J. Frenkel, MD, Department of Paediatrics, University Medical Center Utrecht; Y. Uziel, MD, MSc, Pediatrics, Meir Medical Centre; A. Insalaco, MD, Division of Rheumatology, Department of Pediatric Medicine, Bambino Gesù Children’s Hospital, IRCCS; L. Cantarini, MD, Rheumatology Unit, Policlinico le Scotte, University of Siena; M. Hofer, MD, PhD, Pediatrie, Centre Multisite Romand de Rhumatologie Pediatrique/CHUV; S. Boiu, MD, Pediatric Rheumatology, Université Paris-Descartes; A. Duzova, MD, Pediatric Rheumatology, Hacettepe University, School of Medicine; C. Modesto, MD, PhD, Reumatologia, Hospital Valle de Hebron; A. Bryant, MD, Center of Paediatric and Adolescent Rheumatology, UCL; D. Rigante, MD, Pediatrics, Università Cattolica Sacro Cuore; E. Papadopoulou-Alataki, MD, PhD, Fourth Department of Pediatrics, Aristotle University of Thessaloniki Papageorgiou Hospital; S. Guillaume-Czitrom, MD, CEREMAI, Rhumatologie pédiatrique, CHU Le Kremlin Bicêtre (APHP, University of Paris SUD); J. Kuemmerle-Deschner, MD, Universitatsklinik fur Kinderheilkunde und Jugendmedizin; B. Neven, MD, Université Paris-Descartes, Hôpital Necker-Enfants Malades, Centre de référence national pour les Arthrites Juveniles, Unité d’Immunologie, Hématologie et Rhumatologie Pédiatrique, Université Descartes, Sorbonne Paris Cité, Institut IMAGINE; H. Lachmann, MD, National Amyloidosis Centre, University College London Medical School, Royal Free Campus; A. Martini, MD, Professor, Istituto Giannina Gaslini, UO Pediatria II, Reumatologia; N. Ruperto, MD, MPH, Istituto Giannina Gaslini, UO Pediatria II, Reumatologia; M. Gattorno, MD, Istituto Giannina Gaslini, UO Pediatria II, Reumatologia; S. Ozen, MD, Pediatric Rheumatology, Hacettepe University, School of Medicine. Dr. Gattorno and Dr. Ozen contributed equally to this manuscript. Address correspondence to Dr. M. Gattorno, UO pediatria II, Istituto G. Gaslini, Largo G. Gaslini 5, 16147, Genoa, Italy. E-mail: marcogattorno@ospedale-gaslini.ge.it. Accepted for publication August 14, 2015.
Seza Ozen
From the Familial Mediterranean Fever Arthritis Vasculitis and Orphan Disease Research Center (FAVOR), Gulhane Military Medical Faculty; Epidemiology, Gulhane Military Medical Faculty, Ankara, Turkey; Centre de référence national des maladies auto-inflammatoires, CEREMAI, Rhumatologie pédiatrique, CHU Le Kremlin Bicêtre (APHP, University of Paris SUD), Paris, France; Center of Paediatric and Adolescent Rheumatology, UCL, London, UK; Istituto Giannina Gaslini, UO Pediatria II, Reumatologia, Genoa, Italy; Arabkir Medical Centre, Institute of Child and Adolescents Health, Yerevan, Armenia; Department of Paediatrics, University Medical Center Utrecht, Utrecht, Netherlands; Pediatrics, Meir Medical Centre, Kfar Saba, Israel; Division of Rheumatology, Department of Pediatric Medicine, Bambino Gesù Children’s Hospital, IRCCS, Rome; Rheumatology Unit, Policlinico le Scotte, University of Siena, Siena, Italy; Pediatrie, Centre Multisite Romand de Rhumatologie Pediatrique/Centre Hospitalier, Universitaire Vaudois (CHUV), Lausanne, Switzerland; Pediatric Rheumatology, Université Paris-Descartes, Paris, France; Pediatric Rheumatology, Hacettepe University, School of Medicine, Ankara, Turkey; Reumatologia, Hospital Valle de Hebron, Barcelona, Spain; Pediatrics, Università Cattolica Sacro Cuore, Rome, Italy; Fourth Department of Pediatrics, Aristotle University of Thessaloniki Papageorgiou Hospital, Thessaloniki, Greece; Universitatsklinik fur Kinderheilkunde und Jugendmedizin, Tübingen, Germany; Université Paris-Descartes, Hôpital Necker-Enfants Malades, Centre de référence national pour les Arthrites Juveniles, Unité d’Immunologie, Hématologie et Rhumatologie Pédiatrique, Université Descartes, Sorbonne Paris Cité, Institut IMAGINE, Paris, France; National Amyloidosis Centre, University College London Medical School, Royal Free Campus, London, UK. The Eurofever registry was sponsored by the Autoinflammatory Diseases’ Working Group of the Paediatric Rheumatology European Society and supported by the Executive Agency For Health and Consumers (Project No 2007332) and by Coordination Theme 1 (Health) of the European Community’s FP7 (Eurotraps, grant agreement no. HEALTH-F2-2008-200923). Novartis and SOBI have granted unrestricted educational grants. E. Demirkaya, MD, MSc, FAVOR, Gulhane Military Medical Faculty; C. Saglam, MD, FAVOR, Gulhane Military Medical Faculty; T. Turker, MD, Epidemiology, Gulhane Military Medical Faculty; I. Koné-Paut, MD, CEREMAI, Rhumatologie pédiatrique, CHU Le Kremlin Bicêtre (APHP, University of Paris SUD); P. Woo, MD, Center of Paediatric and Adolescent Rheumatology, UCL; M. Doglio, MD, Istituto Giannina Gaslini, UO Pediatria II, Reumatologia; G. Amaryan, MD, PhD, Arabkir Medical Centre, Institute of Child and Adolescents Health; J. Frenkel, MD, Department of Paediatrics, University Medical Center Utrecht; Y. Uziel, MD, MSc, Pediatrics, Meir Medical Centre; A. Insalaco, MD, Division of Rheumatology, Department of Pediatric Medicine, Bambino Gesù Children’s Hospital, IRCCS; L. Cantarini, MD, Rheumatology Unit, Policlinico le Scotte, University of Siena; M. Hofer, MD, PhD, Pediatrie, Centre Multisite Romand de Rhumatologie Pediatrique/CHUV; S. Boiu, MD, Pediatric Rheumatology, Université Paris-Descartes; A. Duzova, MD, Pediatric Rheumatology, Hacettepe University, School of Medicine; C. Modesto, MD, PhD, Reumatologia, Hospital Valle de Hebron; A. Bryant, MD, Center of Paediatric and Adolescent Rheumatology, UCL; D. Rigante, MD, Pediatrics, Università Cattolica Sacro Cuore; E. Papadopoulou-Alataki, MD, PhD, Fourth Department of Pediatrics, Aristotle University of Thessaloniki Papageorgiou Hospital; S. Guillaume-Czitrom, MD, CEREMAI, Rhumatologie pédiatrique, CHU Le Kremlin Bicêtre (APHP, University of Paris SUD); J. Kuemmerle-Deschner, MD, Universitatsklinik fur Kinderheilkunde und Jugendmedizin; B. Neven, MD, Université Paris-Descartes, Hôpital Necker-Enfants Malades, Centre de référence national pour les Arthrites Juveniles, Unité d’Immunologie, Hématologie et Rhumatologie Pédiatrique, Université Descartes, Sorbonne Paris Cité, Institut IMAGINE; H. Lachmann, MD, National Amyloidosis Centre, University College London Medical School, Royal Free Campus; A. Martini, MD, Professor, Istituto Giannina Gaslini, UO Pediatria II, Reumatologia; N. Ruperto, MD, MPH, Istituto Giannina Gaslini, UO Pediatria II, Reumatologia; M. Gattorno, MD, Istituto Giannina Gaslini, UO Pediatria II, Reumatologia; S. Ozen, MD, Pediatric Rheumatology, Hacettepe University, School of Medicine. Dr. Gattorno and Dr. Ozen contributed equally to this manuscript. Address correspondence to Dr. M. Gattorno, UO pediatria II, Istituto G. Gaslini, Largo G. Gaslini 5, 16147, Genoa, Italy. E-mail: marcogattorno@ospedale-gaslini.ge.it. Accepted for publication August 14, 2015.
Roles: for the Paediatric Rheumatology International Trials Organisations (PRINTO) and Eurofever Project
Published eLetters
eLetters are comments published online only and are not peer-reviewed. Publication of eLetter submissions is not guaranteed, and all submissions are reviewed and edited at the discretion of The Journal's staff.
If you wish to publish Letters to the Editor or Correspondence, please submit through our online submission system ScholarOne Manuscripts.
Jump to comment:
No eLetters have been published for this article.
In this issue
The Journal of Rheumatology
Vol. 51, Issue 4
1 Apr 2024
Performance of Different Diagnostic Criteria for Familial Mediterranean Fever in Children with Periodic Fevers: Results from a Multicenter International Registry
Erkan Demirkaya, Celal Saglam, Turker Turker, Isabelle Koné-Paut, Pat Woo, Matteo Doglio, Gayane Amaryan, Joost Frenkel, Yosef Uziel, Antonella Insalaco, Luca Cantarini, Michael Hofer, Sorina Boiu, Ali Duzova, Consuelo Modesto, Annette Bryant, Donato Rigante, Efimia Papadopoulou-Alataki, Severine Guillaume-Czitrom, Jasmine Kuemmerle-Deschner, Bénédicte Neven, Helen Lachmann, Alberto Martini, Nicolino Ruperto, Marco Gattorno, Seza Ozen
The Journal of Rheumatology Nov 2015, jrheum.141249; DOI: 10.3899/jrheum.141249
Performance of Different Diagnostic Criteria for Familial Mediterranean Fever in Children with Periodic Fevers: Results from a Multicenter International Registry
Erkan Demirkaya, Celal Saglam, Turker Turker, Isabelle Koné-Paut, Pat Woo, Matteo Doglio, Gayane Amaryan, Joost Frenkel, Yosef Uziel, Antonella Insalaco, Luca Cantarini, Michael Hofer, Sorina Boiu, Ali Duzova, Consuelo Modesto, Annette Bryant, Donato Rigante, Efimia Papadopoulou-Alataki, Severine Guillaume-Czitrom, Jasmine Kuemmerle-Deschner, Bénédicte Neven, Helen Lachmann, Alberto Martini, Nicolino Ruperto, Marco Gattorno, Seza Ozen
The Journal of Rheumatology Nov 2015, jrheum.141249; DOI: 10.3899/jrheum.141249