Research ArticleArticle
Autoantibodies to Dense Fine Speckles in Pediatric Diseases and Controls
Heinrike Schmeling, Michael Mahler, Deborah M. Levy, Katharine Moore, Anne M. Stevens, James Wick, Jacob D. McMillan, Gerd Horneff, Shervin Assassi, Julio Charles, Gloria Salazar, Maureen D. Mayes, Earl D. Silverman, Marissa Klien-Gitelman, Tzelan Lee, Hermine I. Brunner, Ann M. Reed and Marvin J. Fritzler
The Journal of Rheumatology October 2015, jrheum.150567; DOI: https://doi.org/10.3899/jrheum.150567
Heinrike Schmeling
From the Department of Paediatrics, Alberta Children’s Hospital, and McCaig Institute for Bone and Joint Health, and Faculty of Medicine, University of Calgary; Alberta Children’s Hospital Research Institute, Calgary, Alberta; Hospital for Sick Children; University of Toronto, Toronto, Ontario, Canada; Inova Diagnostics Inc., San Diego, California; Stanford University/Lucile Packard Children’s Hospital, Stanford, California; Seattle Children’s Research Institute, Department of Pediatrics, University of Washington, Seattle, Washington; Division of Rheumatology, University of Texas Houston Medical School, Houston, Texas; Northwestern University/Lurie Children’s Hospital, Chicago, Illinois; University of Cincinnati; Cincinnati Children’s Hospital and Medical Center, Cincinnati, Ohio; Department of Pediatrics, Duke University, Durham, North Carolina, USA; Department of General Paediatrics, Centre of Paediatrics and Neonatology, Asklepios Clinics, Sankt Augustin, Germany. Funded and supported by resources from Mitogen Advanced Diagnostics Laboratory, the Dawson Jarrock Research Award (Calgary, Alberta, Canada) administered by the Alberta Children’s Foundation/Alberta Children’s Hospital Research Institute, and funds allocated to the Arthritis Society Research Chair by the University of Calgary, Division of Rheumatology, University of Calgary. M. Fritzler is a paid consultant, has received honoraria or gifts in kind from ImmunoConcepts Inc. and Inova Diagnostics Inc. M. Mahler is an employee of Inova Diagnostics Inc., a manufacturer of autoantibody diagnostic kits. H. Schmeling, MD, Department of Paediatrics, Alberta Children’s Hospital, University of Calgary, and Alberta Children’s Hospital Research Institute, and McCaig Institute for Bone and Joint Health; M. Mahler, PhD, Inova Diagnostics Inc.; D.M. Levy, PhD, Hospital for Sick Children, and University of Toronto; K. Moore, MD, Seattle Children’s Research Institute, Department of Pediatrics, University of Washington; A.M. Stevens, MD, PhD, Seattle Children’s Research Institute, Department of Pediatrics, University of Washington; J. Wick, BSc, Faculty of Medicine, University of Calgary; J.D. McMillan, Faculty of Medicine, University of Calgary; G. Horneff, MD, Department of General Paediatrics, Centre of Paediatrics and Neonatology, Asklepios Clinics; S. Assassi, MD, Division of Rheumatology, University of Texas Houston Medical School; J. Charles, BSc, MSc, Division of Rheumatology, University of Texas Houston Medical School; G. Salazar, MD, Division of Rheumatology, University of Texas Houston Medical School; M.D. Mayes, MD, MPH, Division of Rheumatology, University of Texas Houston Medical School; E.D. Silverman, MD, Hospital for Sick Children, and University of Toronto; M. Klien-Gitelman, MD, MPH, Northwestern University/Lurie Children’s Hospital; T. Lee, MD, Stanford University/ Lucile Packard Children’s Hospital; H.I. Brunner, MD, University of Cincinnati, and Cincinnati Children’s Hospital and Medical Center; A.M. Reed, MD, Department of Pediatrics, Duke University; M.J. Fritzler, MD, PhD, Faculty of Medicine, University of Calgary. Address correspondence to Dr. M.J. Fritzler, Cumming School of Medicine, University of Calgary, 3330 Hospital Dr. NW, Calgary, Alberta T2N 4N1, Canada. E-mail: fritzler@ucalgary.ca. Accepted for publication July 30, 2015.
Michael Mahler
From the Department of Paediatrics, Alberta Children’s Hospital, and McCaig Institute for Bone and Joint Health, and Faculty of Medicine, University of Calgary; Alberta Children’s Hospital Research Institute, Calgary, Alberta; Hospital for Sick Children; University of Toronto, Toronto, Ontario, Canada; Inova Diagnostics Inc., San Diego, California; Stanford University/Lucile Packard Children’s Hospital, Stanford, California; Seattle Children’s Research Institute, Department of Pediatrics, University of Washington, Seattle, Washington; Division of Rheumatology, University of Texas Houston Medical School, Houston, Texas; Northwestern University/Lurie Children’s Hospital, Chicago, Illinois; University of Cincinnati; Cincinnati Children’s Hospital and Medical Center, Cincinnati, Ohio; Department of Pediatrics, Duke University, Durham, North Carolina, USA; Department of General Paediatrics, Centre of Paediatrics and Neonatology, Asklepios Clinics, Sankt Augustin, Germany. Funded and supported by resources from Mitogen Advanced Diagnostics Laboratory, the Dawson Jarrock Research Award (Calgary, Alberta, Canada) administered by the Alberta Children’s Foundation/Alberta Children’s Hospital Research Institute, and funds allocated to the Arthritis Society Research Chair by the University of Calgary, Division of Rheumatology, University of Calgary. M. Fritzler is a paid consultant, has received honoraria or gifts in kind from ImmunoConcepts Inc. and Inova Diagnostics Inc. M. Mahler is an employee of Inova Diagnostics Inc., a manufacturer of autoantibody diagnostic kits. H. Schmeling, MD, Department of Paediatrics, Alberta Children’s Hospital, University of Calgary, and Alberta Children’s Hospital Research Institute, and McCaig Institute for Bone and Joint Health; M. Mahler, PhD, Inova Diagnostics Inc.; D.M. Levy, PhD, Hospital for Sick Children, and University of Toronto; K. Moore, MD, Seattle Children’s Research Institute, Department of Pediatrics, University of Washington; A.M. Stevens, MD, PhD, Seattle Children’s Research Institute, Department of Pediatrics, University of Washington; J. Wick, BSc, Faculty of Medicine, University of Calgary; J.D. McMillan, Faculty of Medicine, University of Calgary; G. Horneff, MD, Department of General Paediatrics, Centre of Paediatrics and Neonatology, Asklepios Clinics; S. Assassi, MD, Division of Rheumatology, University of Texas Houston Medical School; J. Charles, BSc, MSc, Division of Rheumatology, University of Texas Houston Medical School; G. Salazar, MD, Division of Rheumatology, University of Texas Houston Medical School; M.D. Mayes, MD, MPH, Division of Rheumatology, University of Texas Houston Medical School; E.D. Silverman, MD, Hospital for Sick Children, and University of Toronto; M. Klien-Gitelman, MD, MPH, Northwestern University/Lurie Children’s Hospital; T. Lee, MD, Stanford University/ Lucile Packard Children’s Hospital; H.I. Brunner, MD, University of Cincinnati, and Cincinnati Children’s Hospital and Medical Center; A.M. Reed, MD, Department of Pediatrics, Duke University; M.J. Fritzler, MD, PhD, Faculty of Medicine, University of Calgary. Address correspondence to Dr. M.J. Fritzler, Cumming School of Medicine, University of Calgary, 3330 Hospital Dr. NW, Calgary, Alberta T2N 4N1, Canada. E-mail: fritzler@ucalgary.ca. Accepted for publication July 30, 2015.
Deborah M. Levy
From the Department of Paediatrics, Alberta Children’s Hospital, and McCaig Institute for Bone and Joint Health, and Faculty of Medicine, University of Calgary; Alberta Children’s Hospital Research Institute, Calgary, Alberta; Hospital for Sick Children; University of Toronto, Toronto, Ontario, Canada; Inova Diagnostics Inc., San Diego, California; Stanford University/Lucile Packard Children’s Hospital, Stanford, California; Seattle Children’s Research Institute, Department of Pediatrics, University of Washington, Seattle, Washington; Division of Rheumatology, University of Texas Houston Medical School, Houston, Texas; Northwestern University/Lurie Children’s Hospital, Chicago, Illinois; University of Cincinnati; Cincinnati Children’s Hospital and Medical Center, Cincinnati, Ohio; Department of Pediatrics, Duke University, Durham, North Carolina, USA; Department of General Paediatrics, Centre of Paediatrics and Neonatology, Asklepios Clinics, Sankt Augustin, Germany. Funded and supported by resources from Mitogen Advanced Diagnostics Laboratory, the Dawson Jarrock Research Award (Calgary, Alberta, Canada) administered by the Alberta Children’s Foundation/Alberta Children’s Hospital Research Institute, and funds allocated to the Arthritis Society Research Chair by the University of Calgary, Division of Rheumatology, University of Calgary. M. Fritzler is a paid consultant, has received honoraria or gifts in kind from ImmunoConcepts Inc. and Inova Diagnostics Inc. M. Mahler is an employee of Inova Diagnostics Inc., a manufacturer of autoantibody diagnostic kits. H. Schmeling, MD, Department of Paediatrics, Alberta Children’s Hospital, University of Calgary, and Alberta Children’s Hospital Research Institute, and McCaig Institute for Bone and Joint Health; M. Mahler, PhD, Inova Diagnostics Inc.; D.M. Levy, PhD, Hospital for Sick Children, and University of Toronto; K. Moore, MD, Seattle Children’s Research Institute, Department of Pediatrics, University of Washington; A.M. Stevens, MD, PhD, Seattle Children’s Research Institute, Department of Pediatrics, University of Washington; J. Wick, BSc, Faculty of Medicine, University of Calgary; J.D. McMillan, Faculty of Medicine, University of Calgary; G. Horneff, MD, Department of General Paediatrics, Centre of Paediatrics and Neonatology, Asklepios Clinics; S. Assassi, MD, Division of Rheumatology, University of Texas Houston Medical School; J. Charles, BSc, MSc, Division of Rheumatology, University of Texas Houston Medical School; G. Salazar, MD, Division of Rheumatology, University of Texas Houston Medical School; M.D. Mayes, MD, MPH, Division of Rheumatology, University of Texas Houston Medical School; E.D. Silverman, MD, Hospital for Sick Children, and University of Toronto; M. Klien-Gitelman, MD, MPH, Northwestern University/Lurie Children’s Hospital; T. Lee, MD, Stanford University/ Lucile Packard Children’s Hospital; H.I. Brunner, MD, University of Cincinnati, and Cincinnati Children’s Hospital and Medical Center; A.M. Reed, MD, Department of Pediatrics, Duke University; M.J. Fritzler, MD, PhD, Faculty of Medicine, University of Calgary. Address correspondence to Dr. M.J. Fritzler, Cumming School of Medicine, University of Calgary, 3330 Hospital Dr. NW, Calgary, Alberta T2N 4N1, Canada. E-mail: fritzler@ucalgary.ca. Accepted for publication July 30, 2015.
Katharine Moore
From the Department of Paediatrics, Alberta Children’s Hospital, and McCaig Institute for Bone and Joint Health, and Faculty of Medicine, University of Calgary; Alberta Children’s Hospital Research Institute, Calgary, Alberta; Hospital for Sick Children; University of Toronto, Toronto, Ontario, Canada; Inova Diagnostics Inc., San Diego, California; Stanford University/Lucile Packard Children’s Hospital, Stanford, California; Seattle Children’s Research Institute, Department of Pediatrics, University of Washington, Seattle, Washington; Division of Rheumatology, University of Texas Houston Medical School, Houston, Texas; Northwestern University/Lurie Children’s Hospital, Chicago, Illinois; University of Cincinnati; Cincinnati Children’s Hospital and Medical Center, Cincinnati, Ohio; Department of Pediatrics, Duke University, Durham, North Carolina, USA; Department of General Paediatrics, Centre of Paediatrics and Neonatology, Asklepios Clinics, Sankt Augustin, Germany. Funded and supported by resources from Mitogen Advanced Diagnostics Laboratory, the Dawson Jarrock Research Award (Calgary, Alberta, Canada) administered by the Alberta Children’s Foundation/Alberta Children’s Hospital Research Institute, and funds allocated to the Arthritis Society Research Chair by the University of Calgary, Division of Rheumatology, University of Calgary. M. Fritzler is a paid consultant, has received honoraria or gifts in kind from ImmunoConcepts Inc. and Inova Diagnostics Inc. M. Mahler is an employee of Inova Diagnostics Inc., a manufacturer of autoantibody diagnostic kits. H. Schmeling, MD, Department of Paediatrics, Alberta Children’s Hospital, University of Calgary, and Alberta Children’s Hospital Research Institute, and McCaig Institute for Bone and Joint Health; M. Mahler, PhD, Inova Diagnostics Inc.; D.M. Levy, PhD, Hospital for Sick Children, and University of Toronto; K. Moore, MD, Seattle Children’s Research Institute, Department of Pediatrics, University of Washington; A.M. Stevens, MD, PhD, Seattle Children’s Research Institute, Department of Pediatrics, University of Washington; J. Wick, BSc, Faculty of Medicine, University of Calgary; J.D. McMillan, Faculty of Medicine, University of Calgary; G. Horneff, MD, Department of General Paediatrics, Centre of Paediatrics and Neonatology, Asklepios Clinics; S. Assassi, MD, Division of Rheumatology, University of Texas Houston Medical School; J. Charles, BSc, MSc, Division of Rheumatology, University of Texas Houston Medical School; G. Salazar, MD, Division of Rheumatology, University of Texas Houston Medical School; M.D. Mayes, MD, MPH, Division of Rheumatology, University of Texas Houston Medical School; E.D. Silverman, MD, Hospital for Sick Children, and University of Toronto; M. Klien-Gitelman, MD, MPH, Northwestern University/Lurie Children’s Hospital; T. Lee, MD, Stanford University/ Lucile Packard Children’s Hospital; H.I. Brunner, MD, University of Cincinnati, and Cincinnati Children’s Hospital and Medical Center; A.M. Reed, MD, Department of Pediatrics, Duke University; M.J. Fritzler, MD, PhD, Faculty of Medicine, University of Calgary. Address correspondence to Dr. M.J. Fritzler, Cumming School of Medicine, University of Calgary, 3330 Hospital Dr. NW, Calgary, Alberta T2N 4N1, Canada. E-mail: fritzler@ucalgary.ca. Accepted for publication July 30, 2015.
Anne M. Stevens
From the Department of Paediatrics, Alberta Children’s Hospital, and McCaig Institute for Bone and Joint Health, and Faculty of Medicine, University of Calgary; Alberta Children’s Hospital Research Institute, Calgary, Alberta; Hospital for Sick Children; University of Toronto, Toronto, Ontario, Canada; Inova Diagnostics Inc., San Diego, California; Stanford University/Lucile Packard Children’s Hospital, Stanford, California; Seattle Children’s Research Institute, Department of Pediatrics, University of Washington, Seattle, Washington; Division of Rheumatology, University of Texas Houston Medical School, Houston, Texas; Northwestern University/Lurie Children’s Hospital, Chicago, Illinois; University of Cincinnati; Cincinnati Children’s Hospital and Medical Center, Cincinnati, Ohio; Department of Pediatrics, Duke University, Durham, North Carolina, USA; Department of General Paediatrics, Centre of Paediatrics and Neonatology, Asklepios Clinics, Sankt Augustin, Germany. Funded and supported by resources from Mitogen Advanced Diagnostics Laboratory, the Dawson Jarrock Research Award (Calgary, Alberta, Canada) administered by the Alberta Children’s Foundation/Alberta Children’s Hospital Research Institute, and funds allocated to the Arthritis Society Research Chair by the University of Calgary, Division of Rheumatology, University of Calgary. M. Fritzler is a paid consultant, has received honoraria or gifts in kind from ImmunoConcepts Inc. and Inova Diagnostics Inc. M. Mahler is an employee of Inova Diagnostics Inc., a manufacturer of autoantibody diagnostic kits. H. Schmeling, MD, Department of Paediatrics, Alberta Children’s Hospital, University of Calgary, and Alberta Children’s Hospital Research Institute, and McCaig Institute for Bone and Joint Health; M. Mahler, PhD, Inova Diagnostics Inc.; D.M. Levy, PhD, Hospital for Sick Children, and University of Toronto; K. Moore, MD, Seattle Children’s Research Institute, Department of Pediatrics, University of Washington; A.M. Stevens, MD, PhD, Seattle Children’s Research Institute, Department of Pediatrics, University of Washington; J. Wick, BSc, Faculty of Medicine, University of Calgary; J.D. McMillan, Faculty of Medicine, University of Calgary; G. Horneff, MD, Department of General Paediatrics, Centre of Paediatrics and Neonatology, Asklepios Clinics; S. Assassi, MD, Division of Rheumatology, University of Texas Houston Medical School; J. Charles, BSc, MSc, Division of Rheumatology, University of Texas Houston Medical School; G. Salazar, MD, Division of Rheumatology, University of Texas Houston Medical School; M.D. Mayes, MD, MPH, Division of Rheumatology, University of Texas Houston Medical School; E.D. Silverman, MD, Hospital for Sick Children, and University of Toronto; M. Klien-Gitelman, MD, MPH, Northwestern University/Lurie Children’s Hospital; T. Lee, MD, Stanford University/ Lucile Packard Children’s Hospital; H.I. Brunner, MD, University of Cincinnati, and Cincinnati Children’s Hospital and Medical Center; A.M. Reed, MD, Department of Pediatrics, Duke University; M.J. Fritzler, MD, PhD, Faculty of Medicine, University of Calgary. Address correspondence to Dr. M.J. Fritzler, Cumming School of Medicine, University of Calgary, 3330 Hospital Dr. NW, Calgary, Alberta T2N 4N1, Canada. E-mail: fritzler@ucalgary.ca. Accepted for publication July 30, 2015.
James Wick
From the Department of Paediatrics, Alberta Children’s Hospital, and McCaig Institute for Bone and Joint Health, and Faculty of Medicine, University of Calgary; Alberta Children’s Hospital Research Institute, Calgary, Alberta; Hospital for Sick Children; University of Toronto, Toronto, Ontario, Canada; Inova Diagnostics Inc., San Diego, California; Stanford University/Lucile Packard Children’s Hospital, Stanford, California; Seattle Children’s Research Institute, Department of Pediatrics, University of Washington, Seattle, Washington; Division of Rheumatology, University of Texas Houston Medical School, Houston, Texas; Northwestern University/Lurie Children’s Hospital, Chicago, Illinois; University of Cincinnati; Cincinnati Children’s Hospital and Medical Center, Cincinnati, Ohio; Department of Pediatrics, Duke University, Durham, North Carolina, USA; Department of General Paediatrics, Centre of Paediatrics and Neonatology, Asklepios Clinics, Sankt Augustin, Germany. Funded and supported by resources from Mitogen Advanced Diagnostics Laboratory, the Dawson Jarrock Research Award (Calgary, Alberta, Canada) administered by the Alberta Children’s Foundation/Alberta Children’s Hospital Research Institute, and funds allocated to the Arthritis Society Research Chair by the University of Calgary, Division of Rheumatology, University of Calgary. M. Fritzler is a paid consultant, has received honoraria or gifts in kind from ImmunoConcepts Inc. and Inova Diagnostics Inc. M. Mahler is an employee of Inova Diagnostics Inc., a manufacturer of autoantibody diagnostic kits. H. Schmeling, MD, Department of Paediatrics, Alberta Children’s Hospital, University of Calgary, and Alberta Children’s Hospital Research Institute, and McCaig Institute for Bone and Joint Health; M. Mahler, PhD, Inova Diagnostics Inc.; D.M. Levy, PhD, Hospital for Sick Children, and University of Toronto; K. Moore, MD, Seattle Children’s Research Institute, Department of Pediatrics, University of Washington; A.M. Stevens, MD, PhD, Seattle Children’s Research Institute, Department of Pediatrics, University of Washington; J. Wick, BSc, Faculty of Medicine, University of Calgary; J.D. McMillan, Faculty of Medicine, University of Calgary; G. Horneff, MD, Department of General Paediatrics, Centre of Paediatrics and Neonatology, Asklepios Clinics; S. Assassi, MD, Division of Rheumatology, University of Texas Houston Medical School; J. Charles, BSc, MSc, Division of Rheumatology, University of Texas Houston Medical School; G. Salazar, MD, Division of Rheumatology, University of Texas Houston Medical School; M.D. Mayes, MD, MPH, Division of Rheumatology, University of Texas Houston Medical School; E.D. Silverman, MD, Hospital for Sick Children, and University of Toronto; M. Klien-Gitelman, MD, MPH, Northwestern University/Lurie Children’s Hospital; T. Lee, MD, Stanford University/ Lucile Packard Children’s Hospital; H.I. Brunner, MD, University of Cincinnati, and Cincinnati Children’s Hospital and Medical Center; A.M. Reed, MD, Department of Pediatrics, Duke University; M.J. Fritzler, MD, PhD, Faculty of Medicine, University of Calgary. Address correspondence to Dr. M.J. Fritzler, Cumming School of Medicine, University of Calgary, 3330 Hospital Dr. NW, Calgary, Alberta T2N 4N1, Canada. E-mail: fritzler@ucalgary.ca. Accepted for publication July 30, 2015.
Jacob D. McMillan
From the Department of Paediatrics, Alberta Children’s Hospital, and McCaig Institute for Bone and Joint Health, and Faculty of Medicine, University of Calgary; Alberta Children’s Hospital Research Institute, Calgary, Alberta; Hospital for Sick Children; University of Toronto, Toronto, Ontario, Canada; Inova Diagnostics Inc., San Diego, California; Stanford University/Lucile Packard Children’s Hospital, Stanford, California; Seattle Children’s Research Institute, Department of Pediatrics, University of Washington, Seattle, Washington; Division of Rheumatology, University of Texas Houston Medical School, Houston, Texas; Northwestern University/Lurie Children’s Hospital, Chicago, Illinois; University of Cincinnati; Cincinnati Children’s Hospital and Medical Center, Cincinnati, Ohio; Department of Pediatrics, Duke University, Durham, North Carolina, USA; Department of General Paediatrics, Centre of Paediatrics and Neonatology, Asklepios Clinics, Sankt Augustin, Germany. Funded and supported by resources from Mitogen Advanced Diagnostics Laboratory, the Dawson Jarrock Research Award (Calgary, Alberta, Canada) administered by the Alberta Children’s Foundation/Alberta Children’s Hospital Research Institute, and funds allocated to the Arthritis Society Research Chair by the University of Calgary, Division of Rheumatology, University of Calgary. M. Fritzler is a paid consultant, has received honoraria or gifts in kind from ImmunoConcepts Inc. and Inova Diagnostics Inc. M. Mahler is an employee of Inova Diagnostics Inc., a manufacturer of autoantibody diagnostic kits. H. Schmeling, MD, Department of Paediatrics, Alberta Children’s Hospital, University of Calgary, and Alberta Children’s Hospital Research Institute, and McCaig Institute for Bone and Joint Health; M. Mahler, PhD, Inova Diagnostics Inc.; D.M. Levy, PhD, Hospital for Sick Children, and University of Toronto; K. Moore, MD, Seattle Children’s Research Institute, Department of Pediatrics, University of Washington; A.M. Stevens, MD, PhD, Seattle Children’s Research Institute, Department of Pediatrics, University of Washington; J. Wick, BSc, Faculty of Medicine, University of Calgary; J.D. McMillan, Faculty of Medicine, University of Calgary; G. Horneff, MD, Department of General Paediatrics, Centre of Paediatrics and Neonatology, Asklepios Clinics; S. Assassi, MD, Division of Rheumatology, University of Texas Houston Medical School; J. Charles, BSc, MSc, Division of Rheumatology, University of Texas Houston Medical School; G. Salazar, MD, Division of Rheumatology, University of Texas Houston Medical School; M.D. Mayes, MD, MPH, Division of Rheumatology, University of Texas Houston Medical School; E.D. Silverman, MD, Hospital for Sick Children, and University of Toronto; M. Klien-Gitelman, MD, MPH, Northwestern University/Lurie Children’s Hospital; T. Lee, MD, Stanford University/ Lucile Packard Children’s Hospital; H.I. Brunner, MD, University of Cincinnati, and Cincinnati Children’s Hospital and Medical Center; A.M. Reed, MD, Department of Pediatrics, Duke University; M.J. Fritzler, MD, PhD, Faculty of Medicine, University of Calgary. Address correspondence to Dr. M.J. Fritzler, Cumming School of Medicine, University of Calgary, 3330 Hospital Dr. NW, Calgary, Alberta T2N 4N1, Canada. E-mail: fritzler@ucalgary.ca. Accepted for publication July 30, 2015.
Gerd Horneff
From the Department of Paediatrics, Alberta Children’s Hospital, and McCaig Institute for Bone and Joint Health, and Faculty of Medicine, University of Calgary; Alberta Children’s Hospital Research Institute, Calgary, Alberta; Hospital for Sick Children; University of Toronto, Toronto, Ontario, Canada; Inova Diagnostics Inc., San Diego, California; Stanford University/Lucile Packard Children’s Hospital, Stanford, California; Seattle Children’s Research Institute, Department of Pediatrics, University of Washington, Seattle, Washington; Division of Rheumatology, University of Texas Houston Medical School, Houston, Texas; Northwestern University/Lurie Children’s Hospital, Chicago, Illinois; University of Cincinnati; Cincinnati Children’s Hospital and Medical Center, Cincinnati, Ohio; Department of Pediatrics, Duke University, Durham, North Carolina, USA; Department of General Paediatrics, Centre of Paediatrics and Neonatology, Asklepios Clinics, Sankt Augustin, Germany. Funded and supported by resources from Mitogen Advanced Diagnostics Laboratory, the Dawson Jarrock Research Award (Calgary, Alberta, Canada) administered by the Alberta Children’s Foundation/Alberta Children’s Hospital Research Institute, and funds allocated to the Arthritis Society Research Chair by the University of Calgary, Division of Rheumatology, University of Calgary. M. Fritzler is a paid consultant, has received honoraria or gifts in kind from ImmunoConcepts Inc. and Inova Diagnostics Inc. M. Mahler is an employee of Inova Diagnostics Inc., a manufacturer of autoantibody diagnostic kits. H. Schmeling, MD, Department of Paediatrics, Alberta Children’s Hospital, University of Calgary, and Alberta Children’s Hospital Research Institute, and McCaig Institute for Bone and Joint Health; M. Mahler, PhD, Inova Diagnostics Inc.; D.M. Levy, PhD, Hospital for Sick Children, and University of Toronto; K. Moore, MD, Seattle Children’s Research Institute, Department of Pediatrics, University of Washington; A.M. Stevens, MD, PhD, Seattle Children’s Research Institute, Department of Pediatrics, University of Washington; J. Wick, BSc, Faculty of Medicine, University of Calgary; J.D. McMillan, Faculty of Medicine, University of Calgary; G. Horneff, MD, Department of General Paediatrics, Centre of Paediatrics and Neonatology, Asklepios Clinics; S. Assassi, MD, Division of Rheumatology, University of Texas Houston Medical School; J. Charles, BSc, MSc, Division of Rheumatology, University of Texas Houston Medical School; G. Salazar, MD, Division of Rheumatology, University of Texas Houston Medical School; M.D. Mayes, MD, MPH, Division of Rheumatology, University of Texas Houston Medical School; E.D. Silverman, MD, Hospital for Sick Children, and University of Toronto; M. Klien-Gitelman, MD, MPH, Northwestern University/Lurie Children’s Hospital; T. Lee, MD, Stanford University/ Lucile Packard Children’s Hospital; H.I. Brunner, MD, University of Cincinnati, and Cincinnati Children’s Hospital and Medical Center; A.M. Reed, MD, Department of Pediatrics, Duke University; M.J. Fritzler, MD, PhD, Faculty of Medicine, University of Calgary. Address correspondence to Dr. M.J. Fritzler, Cumming School of Medicine, University of Calgary, 3330 Hospital Dr. NW, Calgary, Alberta T2N 4N1, Canada. E-mail: fritzler@ucalgary.ca. Accepted for publication July 30, 2015.
Shervin Assassi
From the Department of Paediatrics, Alberta Children’s Hospital, and McCaig Institute for Bone and Joint Health, and Faculty of Medicine, University of Calgary; Alberta Children’s Hospital Research Institute, Calgary, Alberta; Hospital for Sick Children; University of Toronto, Toronto, Ontario, Canada; Inova Diagnostics Inc., San Diego, California; Stanford University/Lucile Packard Children’s Hospital, Stanford, California; Seattle Children’s Research Institute, Department of Pediatrics, University of Washington, Seattle, Washington; Division of Rheumatology, University of Texas Houston Medical School, Houston, Texas; Northwestern University/Lurie Children’s Hospital, Chicago, Illinois; University of Cincinnati; Cincinnati Children’s Hospital and Medical Center, Cincinnati, Ohio; Department of Pediatrics, Duke University, Durham, North Carolina, USA; Department of General Paediatrics, Centre of Paediatrics and Neonatology, Asklepios Clinics, Sankt Augustin, Germany. Funded and supported by resources from Mitogen Advanced Diagnostics Laboratory, the Dawson Jarrock Research Award (Calgary, Alberta, Canada) administered by the Alberta Children’s Foundation/Alberta Children’s Hospital Research Institute, and funds allocated to the Arthritis Society Research Chair by the University of Calgary, Division of Rheumatology, University of Calgary. M. Fritzler is a paid consultant, has received honoraria or gifts in kind from ImmunoConcepts Inc. and Inova Diagnostics Inc. M. Mahler is an employee of Inova Diagnostics Inc., a manufacturer of autoantibody diagnostic kits. H. Schmeling, MD, Department of Paediatrics, Alberta Children’s Hospital, University of Calgary, and Alberta Children’s Hospital Research Institute, and McCaig Institute for Bone and Joint Health; M. Mahler, PhD, Inova Diagnostics Inc.; D.M. Levy, PhD, Hospital for Sick Children, and University of Toronto; K. Moore, MD, Seattle Children’s Research Institute, Department of Pediatrics, University of Washington; A.M. Stevens, MD, PhD, Seattle Children’s Research Institute, Department of Pediatrics, University of Washington; J. Wick, BSc, Faculty of Medicine, University of Calgary; J.D. McMillan, Faculty of Medicine, University of Calgary; G. Horneff, MD, Department of General Paediatrics, Centre of Paediatrics and Neonatology, Asklepios Clinics; S. Assassi, MD, Division of Rheumatology, University of Texas Houston Medical School; J. Charles, BSc, MSc, Division of Rheumatology, University of Texas Houston Medical School; G. Salazar, MD, Division of Rheumatology, University of Texas Houston Medical School; M.D. Mayes, MD, MPH, Division of Rheumatology, University of Texas Houston Medical School; E.D. Silverman, MD, Hospital for Sick Children, and University of Toronto; M. Klien-Gitelman, MD, MPH, Northwestern University/Lurie Children’s Hospital; T. Lee, MD, Stanford University/ Lucile Packard Children’s Hospital; H.I. Brunner, MD, University of Cincinnati, and Cincinnati Children’s Hospital and Medical Center; A.M. Reed, MD, Department of Pediatrics, Duke University; M.J. Fritzler, MD, PhD, Faculty of Medicine, University of Calgary. Address correspondence to Dr. M.J. Fritzler, Cumming School of Medicine, University of Calgary, 3330 Hospital Dr. NW, Calgary, Alberta T2N 4N1, Canada. E-mail: fritzler@ucalgary.ca. Accepted for publication July 30, 2015.
Julio Charles
From the Department of Paediatrics, Alberta Children’s Hospital, and McCaig Institute for Bone and Joint Health, and Faculty of Medicine, University of Calgary; Alberta Children’s Hospital Research Institute, Calgary, Alberta; Hospital for Sick Children; University of Toronto, Toronto, Ontario, Canada; Inova Diagnostics Inc., San Diego, California; Stanford University/Lucile Packard Children’s Hospital, Stanford, California; Seattle Children’s Research Institute, Department of Pediatrics, University of Washington, Seattle, Washington; Division of Rheumatology, University of Texas Houston Medical School, Houston, Texas; Northwestern University/Lurie Children’s Hospital, Chicago, Illinois; University of Cincinnati; Cincinnati Children’s Hospital and Medical Center, Cincinnati, Ohio; Department of Pediatrics, Duke University, Durham, North Carolina, USA; Department of General Paediatrics, Centre of Paediatrics and Neonatology, Asklepios Clinics, Sankt Augustin, Germany. Funded and supported by resources from Mitogen Advanced Diagnostics Laboratory, the Dawson Jarrock Research Award (Calgary, Alberta, Canada) administered by the Alberta Children’s Foundation/Alberta Children’s Hospital Research Institute, and funds allocated to the Arthritis Society Research Chair by the University of Calgary, Division of Rheumatology, University of Calgary. M. Fritzler is a paid consultant, has received honoraria or gifts in kind from ImmunoConcepts Inc. and Inova Diagnostics Inc. M. Mahler is an employee of Inova Diagnostics Inc., a manufacturer of autoantibody diagnostic kits. H. Schmeling, MD, Department of Paediatrics, Alberta Children’s Hospital, University of Calgary, and Alberta Children’s Hospital Research Institute, and McCaig Institute for Bone and Joint Health; M. Mahler, PhD, Inova Diagnostics Inc.; D.M. Levy, PhD, Hospital for Sick Children, and University of Toronto; K. Moore, MD, Seattle Children’s Research Institute, Department of Pediatrics, University of Washington; A.M. Stevens, MD, PhD, Seattle Children’s Research Institute, Department of Pediatrics, University of Washington; J. Wick, BSc, Faculty of Medicine, University of Calgary; J.D. McMillan, Faculty of Medicine, University of Calgary; G. Horneff, MD, Department of General Paediatrics, Centre of Paediatrics and Neonatology, Asklepios Clinics; S. Assassi, MD, Division of Rheumatology, University of Texas Houston Medical School; J. Charles, BSc, MSc, Division of Rheumatology, University of Texas Houston Medical School; G. Salazar, MD, Division of Rheumatology, University of Texas Houston Medical School; M.D. Mayes, MD, MPH, Division of Rheumatology, University of Texas Houston Medical School; E.D. Silverman, MD, Hospital for Sick Children, and University of Toronto; M. Klien-Gitelman, MD, MPH, Northwestern University/Lurie Children’s Hospital; T. Lee, MD, Stanford University/ Lucile Packard Children’s Hospital; H.I. Brunner, MD, University of Cincinnati, and Cincinnati Children’s Hospital and Medical Center; A.M. Reed, MD, Department of Pediatrics, Duke University; M.J. Fritzler, MD, PhD, Faculty of Medicine, University of Calgary. Address correspondence to Dr. M.J. Fritzler, Cumming School of Medicine, University of Calgary, 3330 Hospital Dr. NW, Calgary, Alberta T2N 4N1, Canada. E-mail: fritzler@ucalgary.ca. Accepted for publication July 30, 2015.
Gloria Salazar
From the Department of Paediatrics, Alberta Children’s Hospital, and McCaig Institute for Bone and Joint Health, and Faculty of Medicine, University of Calgary; Alberta Children’s Hospital Research Institute, Calgary, Alberta; Hospital for Sick Children; University of Toronto, Toronto, Ontario, Canada; Inova Diagnostics Inc., San Diego, California; Stanford University/Lucile Packard Children’s Hospital, Stanford, California; Seattle Children’s Research Institute, Department of Pediatrics, University of Washington, Seattle, Washington; Division of Rheumatology, University of Texas Houston Medical School, Houston, Texas; Northwestern University/Lurie Children’s Hospital, Chicago, Illinois; University of Cincinnati; Cincinnati Children’s Hospital and Medical Center, Cincinnati, Ohio; Department of Pediatrics, Duke University, Durham, North Carolina, USA; Department of General Paediatrics, Centre of Paediatrics and Neonatology, Asklepios Clinics, Sankt Augustin, Germany. Funded and supported by resources from Mitogen Advanced Diagnostics Laboratory, the Dawson Jarrock Research Award (Calgary, Alberta, Canada) administered by the Alberta Children’s Foundation/Alberta Children’s Hospital Research Institute, and funds allocated to the Arthritis Society Research Chair by the University of Calgary, Division of Rheumatology, University of Calgary. M. Fritzler is a paid consultant, has received honoraria or gifts in kind from ImmunoConcepts Inc. and Inova Diagnostics Inc. M. Mahler is an employee of Inova Diagnostics Inc., a manufacturer of autoantibody diagnostic kits. H. Schmeling, MD, Department of Paediatrics, Alberta Children’s Hospital, University of Calgary, and Alberta Children’s Hospital Research Institute, and McCaig Institute for Bone and Joint Health; M. Mahler, PhD, Inova Diagnostics Inc.; D.M. Levy, PhD, Hospital for Sick Children, and University of Toronto; K. Moore, MD, Seattle Children’s Research Institute, Department of Pediatrics, University of Washington; A.M. Stevens, MD, PhD, Seattle Children’s Research Institute, Department of Pediatrics, University of Washington; J. Wick, BSc, Faculty of Medicine, University of Calgary; J.D. McMillan, Faculty of Medicine, University of Calgary; G. Horneff, MD, Department of General Paediatrics, Centre of Paediatrics and Neonatology, Asklepios Clinics; S. Assassi, MD, Division of Rheumatology, University of Texas Houston Medical School; J. Charles, BSc, MSc, Division of Rheumatology, University of Texas Houston Medical School; G. Salazar, MD, Division of Rheumatology, University of Texas Houston Medical School; M.D. Mayes, MD, MPH, Division of Rheumatology, University of Texas Houston Medical School; E.D. Silverman, MD, Hospital for Sick Children, and University of Toronto; M. Klien-Gitelman, MD, MPH, Northwestern University/Lurie Children’s Hospital; T. Lee, MD, Stanford University/ Lucile Packard Children’s Hospital; H.I. Brunner, MD, University of Cincinnati, and Cincinnati Children’s Hospital and Medical Center; A.M. Reed, MD, Department of Pediatrics, Duke University; M.J. Fritzler, MD, PhD, Faculty of Medicine, University of Calgary. Address correspondence to Dr. M.J. Fritzler, Cumming School of Medicine, University of Calgary, 3330 Hospital Dr. NW, Calgary, Alberta T2N 4N1, Canada. E-mail: fritzler@ucalgary.ca. Accepted for publication July 30, 2015.
Maureen D. Mayes
From the Department of Paediatrics, Alberta Children’s Hospital, and McCaig Institute for Bone and Joint Health, and Faculty of Medicine, University of Calgary; Alberta Children’s Hospital Research Institute, Calgary, Alberta; Hospital for Sick Children; University of Toronto, Toronto, Ontario, Canada; Inova Diagnostics Inc., San Diego, California; Stanford University/Lucile Packard Children’s Hospital, Stanford, California; Seattle Children’s Research Institute, Department of Pediatrics, University of Washington, Seattle, Washington; Division of Rheumatology, University of Texas Houston Medical School, Houston, Texas; Northwestern University/Lurie Children’s Hospital, Chicago, Illinois; University of Cincinnati; Cincinnati Children’s Hospital and Medical Center, Cincinnati, Ohio; Department of Pediatrics, Duke University, Durham, North Carolina, USA; Department of General Paediatrics, Centre of Paediatrics and Neonatology, Asklepios Clinics, Sankt Augustin, Germany. Funded and supported by resources from Mitogen Advanced Diagnostics Laboratory, the Dawson Jarrock Research Award (Calgary, Alberta, Canada) administered by the Alberta Children’s Foundation/Alberta Children’s Hospital Research Institute, and funds allocated to the Arthritis Society Research Chair by the University of Calgary, Division of Rheumatology, University of Calgary. M. Fritzler is a paid consultant, has received honoraria or gifts in kind from ImmunoConcepts Inc. and Inova Diagnostics Inc. M. Mahler is an employee of Inova Diagnostics Inc., a manufacturer of autoantibody diagnostic kits. H. Schmeling, MD, Department of Paediatrics, Alberta Children’s Hospital, University of Calgary, and Alberta Children’s Hospital Research Institute, and McCaig Institute for Bone and Joint Health; M. Mahler, PhD, Inova Diagnostics Inc.; D.M. Levy, PhD, Hospital for Sick Children, and University of Toronto; K. Moore, MD, Seattle Children’s Research Institute, Department of Pediatrics, University of Washington; A.M. Stevens, MD, PhD, Seattle Children’s Research Institute, Department of Pediatrics, University of Washington; J. Wick, BSc, Faculty of Medicine, University of Calgary; J.D. McMillan, Faculty of Medicine, University of Calgary; G. Horneff, MD, Department of General Paediatrics, Centre of Paediatrics and Neonatology, Asklepios Clinics; S. Assassi, MD, Division of Rheumatology, University of Texas Houston Medical School; J. Charles, BSc, MSc, Division of Rheumatology, University of Texas Houston Medical School; G. Salazar, MD, Division of Rheumatology, University of Texas Houston Medical School; M.D. Mayes, MD, MPH, Division of Rheumatology, University of Texas Houston Medical School; E.D. Silverman, MD, Hospital for Sick Children, and University of Toronto; M. Klien-Gitelman, MD, MPH, Northwestern University/Lurie Children’s Hospital; T. Lee, MD, Stanford University/ Lucile Packard Children’s Hospital; H.I. Brunner, MD, University of Cincinnati, and Cincinnati Children’s Hospital and Medical Center; A.M. Reed, MD, Department of Pediatrics, Duke University; M.J. Fritzler, MD, PhD, Faculty of Medicine, University of Calgary. Address correspondence to Dr. M.J. Fritzler, Cumming School of Medicine, University of Calgary, 3330 Hospital Dr. NW, Calgary, Alberta T2N 4N1, Canada. E-mail: fritzler@ucalgary.ca. Accepted for publication July 30, 2015.
Earl D. Silverman
From the Department of Paediatrics, Alberta Children’s Hospital, and McCaig Institute for Bone and Joint Health, and Faculty of Medicine, University of Calgary; Alberta Children’s Hospital Research Institute, Calgary, Alberta; Hospital for Sick Children; University of Toronto, Toronto, Ontario, Canada; Inova Diagnostics Inc., San Diego, California; Stanford University/Lucile Packard Children’s Hospital, Stanford, California; Seattle Children’s Research Institute, Department of Pediatrics, University of Washington, Seattle, Washington; Division of Rheumatology, University of Texas Houston Medical School, Houston, Texas; Northwestern University/Lurie Children’s Hospital, Chicago, Illinois; University of Cincinnati; Cincinnati Children’s Hospital and Medical Center, Cincinnati, Ohio; Department of Pediatrics, Duke University, Durham, North Carolina, USA; Department of General Paediatrics, Centre of Paediatrics and Neonatology, Asklepios Clinics, Sankt Augustin, Germany. Funded and supported by resources from Mitogen Advanced Diagnostics Laboratory, the Dawson Jarrock Research Award (Calgary, Alberta, Canada) administered by the Alberta Children’s Foundation/Alberta Children’s Hospital Research Institute, and funds allocated to the Arthritis Society Research Chair by the University of Calgary, Division of Rheumatology, University of Calgary. M. Fritzler is a paid consultant, has received honoraria or gifts in kind from ImmunoConcepts Inc. and Inova Diagnostics Inc. M. Mahler is an employee of Inova Diagnostics Inc., a manufacturer of autoantibody diagnostic kits. H. Schmeling, MD, Department of Paediatrics, Alberta Children’s Hospital, University of Calgary, and Alberta Children’s Hospital Research Institute, and McCaig Institute for Bone and Joint Health; M. Mahler, PhD, Inova Diagnostics Inc.; D.M. Levy, PhD, Hospital for Sick Children, and University of Toronto; K. Moore, MD, Seattle Children’s Research Institute, Department of Pediatrics, University of Washington; A.M. Stevens, MD, PhD, Seattle Children’s Research Institute, Department of Pediatrics, University of Washington; J. Wick, BSc, Faculty of Medicine, University of Calgary; J.D. McMillan, Faculty of Medicine, University of Calgary; G. Horneff, MD, Department of General Paediatrics, Centre of Paediatrics and Neonatology, Asklepios Clinics; S. Assassi, MD, Division of Rheumatology, University of Texas Houston Medical School; J. Charles, BSc, MSc, Division of Rheumatology, University of Texas Houston Medical School; G. Salazar, MD, Division of Rheumatology, University of Texas Houston Medical School; M.D. Mayes, MD, MPH, Division of Rheumatology, University of Texas Houston Medical School; E.D. Silverman, MD, Hospital for Sick Children, and University of Toronto; M. Klien-Gitelman, MD, MPH, Northwestern University/Lurie Children’s Hospital; T. Lee, MD, Stanford University/ Lucile Packard Children’s Hospital; H.I. Brunner, MD, University of Cincinnati, and Cincinnati Children’s Hospital and Medical Center; A.M. Reed, MD, Department of Pediatrics, Duke University; M.J. Fritzler, MD, PhD, Faculty of Medicine, University of Calgary. Address correspondence to Dr. M.J. Fritzler, Cumming School of Medicine, University of Calgary, 3330 Hospital Dr. NW, Calgary, Alberta T2N 4N1, Canada. E-mail: fritzler@ucalgary.ca. Accepted for publication July 30, 2015.
Marissa Klien-Gitelman
From the Department of Paediatrics, Alberta Children’s Hospital, and McCaig Institute for Bone and Joint Health, and Faculty of Medicine, University of Calgary; Alberta Children’s Hospital Research Institute, Calgary, Alberta; Hospital for Sick Children; University of Toronto, Toronto, Ontario, Canada; Inova Diagnostics Inc., San Diego, California; Stanford University/Lucile Packard Children’s Hospital, Stanford, California; Seattle Children’s Research Institute, Department of Pediatrics, University of Washington, Seattle, Washington; Division of Rheumatology, University of Texas Houston Medical School, Houston, Texas; Northwestern University/Lurie Children’s Hospital, Chicago, Illinois; University of Cincinnati; Cincinnati Children’s Hospital and Medical Center, Cincinnati, Ohio; Department of Pediatrics, Duke University, Durham, North Carolina, USA; Department of General Paediatrics, Centre of Paediatrics and Neonatology, Asklepios Clinics, Sankt Augustin, Germany. Funded and supported by resources from Mitogen Advanced Diagnostics Laboratory, the Dawson Jarrock Research Award (Calgary, Alberta, Canada) administered by the Alberta Children’s Foundation/Alberta Children’s Hospital Research Institute, and funds allocated to the Arthritis Society Research Chair by the University of Calgary, Division of Rheumatology, University of Calgary. M. Fritzler is a paid consultant, has received honoraria or gifts in kind from ImmunoConcepts Inc. and Inova Diagnostics Inc. M. Mahler is an employee of Inova Diagnostics Inc., a manufacturer of autoantibody diagnostic kits. H. Schmeling, MD, Department of Paediatrics, Alberta Children’s Hospital, University of Calgary, and Alberta Children’s Hospital Research Institute, and McCaig Institute for Bone and Joint Health; M. Mahler, PhD, Inova Diagnostics Inc.; D.M. Levy, PhD, Hospital for Sick Children, and University of Toronto; K. Moore, MD, Seattle Children’s Research Institute, Department of Pediatrics, University of Washington; A.M. Stevens, MD, PhD, Seattle Children’s Research Institute, Department of Pediatrics, University of Washington; J. Wick, BSc, Faculty of Medicine, University of Calgary; J.D. McMillan, Faculty of Medicine, University of Calgary; G. Horneff, MD, Department of General Paediatrics, Centre of Paediatrics and Neonatology, Asklepios Clinics; S. Assassi, MD, Division of Rheumatology, University of Texas Houston Medical School; J. Charles, BSc, MSc, Division of Rheumatology, University of Texas Houston Medical School; G. Salazar, MD, Division of Rheumatology, University of Texas Houston Medical School; M.D. Mayes, MD, MPH, Division of Rheumatology, University of Texas Houston Medical School; E.D. Silverman, MD, Hospital for Sick Children, and University of Toronto; M. Klien-Gitelman, MD, MPH, Northwestern University/Lurie Children’s Hospital; T. Lee, MD, Stanford University/ Lucile Packard Children’s Hospital; H.I. Brunner, MD, University of Cincinnati, and Cincinnati Children’s Hospital and Medical Center; A.M. Reed, MD, Department of Pediatrics, Duke University; M.J. Fritzler, MD, PhD, Faculty of Medicine, University of Calgary. Address correspondence to Dr. M.J. Fritzler, Cumming School of Medicine, University of Calgary, 3330 Hospital Dr. NW, Calgary, Alberta T2N 4N1, Canada. E-mail: fritzler@ucalgary.ca. Accepted for publication July 30, 2015.
Tzelan Lee
From the Department of Paediatrics, Alberta Children’s Hospital, and McCaig Institute for Bone and Joint Health, and Faculty of Medicine, University of Calgary; Alberta Children’s Hospital Research Institute, Calgary, Alberta; Hospital for Sick Children; University of Toronto, Toronto, Ontario, Canada; Inova Diagnostics Inc., San Diego, California; Stanford University/Lucile Packard Children’s Hospital, Stanford, California; Seattle Children’s Research Institute, Department of Pediatrics, University of Washington, Seattle, Washington; Division of Rheumatology, University of Texas Houston Medical School, Houston, Texas; Northwestern University/Lurie Children’s Hospital, Chicago, Illinois; University of Cincinnati; Cincinnati Children’s Hospital and Medical Center, Cincinnati, Ohio; Department of Pediatrics, Duke University, Durham, North Carolina, USA; Department of General Paediatrics, Centre of Paediatrics and Neonatology, Asklepios Clinics, Sankt Augustin, Germany. Funded and supported by resources from Mitogen Advanced Diagnostics Laboratory, the Dawson Jarrock Research Award (Calgary, Alberta, Canada) administered by the Alberta Children’s Foundation/Alberta Children’s Hospital Research Institute, and funds allocated to the Arthritis Society Research Chair by the University of Calgary, Division of Rheumatology, University of Calgary. M. Fritzler is a paid consultant, has received honoraria or gifts in kind from ImmunoConcepts Inc. and Inova Diagnostics Inc. M. Mahler is an employee of Inova Diagnostics Inc., a manufacturer of autoantibody diagnostic kits. H. Schmeling, MD, Department of Paediatrics, Alberta Children’s Hospital, University of Calgary, and Alberta Children’s Hospital Research Institute, and McCaig Institute for Bone and Joint Health; M. Mahler, PhD, Inova Diagnostics Inc.; D.M. Levy, PhD, Hospital for Sick Children, and University of Toronto; K. Moore, MD, Seattle Children’s Research Institute, Department of Pediatrics, University of Washington; A.M. Stevens, MD, PhD, Seattle Children’s Research Institute, Department of Pediatrics, University of Washington; J. Wick, BSc, Faculty of Medicine, University of Calgary; J.D. McMillan, Faculty of Medicine, University of Calgary; G. Horneff, MD, Department of General Paediatrics, Centre of Paediatrics and Neonatology, Asklepios Clinics; S. Assassi, MD, Division of Rheumatology, University of Texas Houston Medical School; J. Charles, BSc, MSc, Division of Rheumatology, University of Texas Houston Medical School; G. Salazar, MD, Division of Rheumatology, University of Texas Houston Medical School; M.D. Mayes, MD, MPH, Division of Rheumatology, University of Texas Houston Medical School; E.D. Silverman, MD, Hospital for Sick Children, and University of Toronto; M. Klien-Gitelman, MD, MPH, Northwestern University/Lurie Children’s Hospital; T. Lee, MD, Stanford University/ Lucile Packard Children’s Hospital; H.I. Brunner, MD, University of Cincinnati, and Cincinnati Children’s Hospital and Medical Center; A.M. Reed, MD, Department of Pediatrics, Duke University; M.J. Fritzler, MD, PhD, Faculty of Medicine, University of Calgary. Address correspondence to Dr. M.J. Fritzler, Cumming School of Medicine, University of Calgary, 3330 Hospital Dr. NW, Calgary, Alberta T2N 4N1, Canada. E-mail: fritzler@ucalgary.ca. Accepted for publication July 30, 2015.
Hermine I. Brunner
From the Department of Paediatrics, Alberta Children’s Hospital, and McCaig Institute for Bone and Joint Health, and Faculty of Medicine, University of Calgary; Alberta Children’s Hospital Research Institute, Calgary, Alberta; Hospital for Sick Children; University of Toronto, Toronto, Ontario, Canada; Inova Diagnostics Inc., San Diego, California; Stanford University/Lucile Packard Children’s Hospital, Stanford, California; Seattle Children’s Research Institute, Department of Pediatrics, University of Washington, Seattle, Washington; Division of Rheumatology, University of Texas Houston Medical School, Houston, Texas; Northwestern University/Lurie Children’s Hospital, Chicago, Illinois; University of Cincinnati; Cincinnati Children’s Hospital and Medical Center, Cincinnati, Ohio; Department of Pediatrics, Duke University, Durham, North Carolina, USA; Department of General Paediatrics, Centre of Paediatrics and Neonatology, Asklepios Clinics, Sankt Augustin, Germany. Funded and supported by resources from Mitogen Advanced Diagnostics Laboratory, the Dawson Jarrock Research Award (Calgary, Alberta, Canada) administered by the Alberta Children’s Foundation/Alberta Children’s Hospital Research Institute, and funds allocated to the Arthritis Society Research Chair by the University of Calgary, Division of Rheumatology, University of Calgary. M. Fritzler is a paid consultant, has received honoraria or gifts in kind from ImmunoConcepts Inc. and Inova Diagnostics Inc. M. Mahler is an employee of Inova Diagnostics Inc., a manufacturer of autoantibody diagnostic kits. H. Schmeling, MD, Department of Paediatrics, Alberta Children’s Hospital, University of Calgary, and Alberta Children’s Hospital Research Institute, and McCaig Institute for Bone and Joint Health; M. Mahler, PhD, Inova Diagnostics Inc.; D.M. Levy, PhD, Hospital for Sick Children, and University of Toronto; K. Moore, MD, Seattle Children’s Research Institute, Department of Pediatrics, University of Washington; A.M. Stevens, MD, PhD, Seattle Children’s Research Institute, Department of Pediatrics, University of Washington; J. Wick, BSc, Faculty of Medicine, University of Calgary; J.D. McMillan, Faculty of Medicine, University of Calgary; G. Horneff, MD, Department of General Paediatrics, Centre of Paediatrics and Neonatology, Asklepios Clinics; S. Assassi, MD, Division of Rheumatology, University of Texas Houston Medical School; J. Charles, BSc, MSc, Division of Rheumatology, University of Texas Houston Medical School; G. Salazar, MD, Division of Rheumatology, University of Texas Houston Medical School; M.D. Mayes, MD, MPH, Division of Rheumatology, University of Texas Houston Medical School; E.D. Silverman, MD, Hospital for Sick Children, and University of Toronto; M. Klien-Gitelman, MD, MPH, Northwestern University/Lurie Children’s Hospital; T. Lee, MD, Stanford University/ Lucile Packard Children’s Hospital; H.I. Brunner, MD, University of Cincinnati, and Cincinnati Children’s Hospital and Medical Center; A.M. Reed, MD, Department of Pediatrics, Duke University; M.J. Fritzler, MD, PhD, Faculty of Medicine, University of Calgary. Address correspondence to Dr. M.J. Fritzler, Cumming School of Medicine, University of Calgary, 3330 Hospital Dr. NW, Calgary, Alberta T2N 4N1, Canada. E-mail: fritzler@ucalgary.ca. Accepted for publication July 30, 2015.
Ann M. Reed
From the Department of Paediatrics, Alberta Children’s Hospital, and McCaig Institute for Bone and Joint Health, and Faculty of Medicine, University of Calgary; Alberta Children’s Hospital Research Institute, Calgary, Alberta; Hospital for Sick Children; University of Toronto, Toronto, Ontario, Canada; Inova Diagnostics Inc., San Diego, California; Stanford University/Lucile Packard Children’s Hospital, Stanford, California; Seattle Children’s Research Institute, Department of Pediatrics, University of Washington, Seattle, Washington; Division of Rheumatology, University of Texas Houston Medical School, Houston, Texas; Northwestern University/Lurie Children’s Hospital, Chicago, Illinois; University of Cincinnati; Cincinnati Children’s Hospital and Medical Center, Cincinnati, Ohio; Department of Pediatrics, Duke University, Durham, North Carolina, USA; Department of General Paediatrics, Centre of Paediatrics and Neonatology, Asklepios Clinics, Sankt Augustin, Germany. Funded and supported by resources from Mitogen Advanced Diagnostics Laboratory, the Dawson Jarrock Research Award (Calgary, Alberta, Canada) administered by the Alberta Children’s Foundation/Alberta Children’s Hospital Research Institute, and funds allocated to the Arthritis Society Research Chair by the University of Calgary, Division of Rheumatology, University of Calgary. M. Fritzler is a paid consultant, has received honoraria or gifts in kind from ImmunoConcepts Inc. and Inova Diagnostics Inc. M. Mahler is an employee of Inova Diagnostics Inc., a manufacturer of autoantibody diagnostic kits. H. Schmeling, MD, Department of Paediatrics, Alberta Children’s Hospital, University of Calgary, and Alberta Children’s Hospital Research Institute, and McCaig Institute for Bone and Joint Health; M. Mahler, PhD, Inova Diagnostics Inc.; D.M. Levy, PhD, Hospital for Sick Children, and University of Toronto; K. Moore, MD, Seattle Children’s Research Institute, Department of Pediatrics, University of Washington; A.M. Stevens, MD, PhD, Seattle Children’s Research Institute, Department of Pediatrics, University of Washington; J. Wick, BSc, Faculty of Medicine, University of Calgary; J.D. McMillan, Faculty of Medicine, University of Calgary; G. Horneff, MD, Department of General Paediatrics, Centre of Paediatrics and Neonatology, Asklepios Clinics; S. Assassi, MD, Division of Rheumatology, University of Texas Houston Medical School; J. Charles, BSc, MSc, Division of Rheumatology, University of Texas Houston Medical School; G. Salazar, MD, Division of Rheumatology, University of Texas Houston Medical School; M.D. Mayes, MD, MPH, Division of Rheumatology, University of Texas Houston Medical School; E.D. Silverman, MD, Hospital for Sick Children, and University of Toronto; M. Klien-Gitelman, MD, MPH, Northwestern University/Lurie Children’s Hospital; T. Lee, MD, Stanford University/ Lucile Packard Children’s Hospital; H.I. Brunner, MD, University of Cincinnati, and Cincinnati Children’s Hospital and Medical Center; A.M. Reed, MD, Department of Pediatrics, Duke University; M.J. Fritzler, MD, PhD, Faculty of Medicine, University of Calgary. Address correspondence to Dr. M.J. Fritzler, Cumming School of Medicine, University of Calgary, 3330 Hospital Dr. NW, Calgary, Alberta T2N 4N1, Canada. E-mail: fritzler@ucalgary.ca. Accepted for publication July 30, 2015.
Marvin J. Fritzler
From the Department of Paediatrics, Alberta Children’s Hospital, and McCaig Institute for Bone and Joint Health, and Faculty of Medicine, University of Calgary; Alberta Children’s Hospital Research Institute, Calgary, Alberta; Hospital for Sick Children; University of Toronto, Toronto, Ontario, Canada; Inova Diagnostics Inc., San Diego, California; Stanford University/Lucile Packard Children’s Hospital, Stanford, California; Seattle Children’s Research Institute, Department of Pediatrics, University of Washington, Seattle, Washington; Division of Rheumatology, University of Texas Houston Medical School, Houston, Texas; Northwestern University/Lurie Children’s Hospital, Chicago, Illinois; University of Cincinnati; Cincinnati Children’s Hospital and Medical Center, Cincinnati, Ohio; Department of Pediatrics, Duke University, Durham, North Carolina, USA; Department of General Paediatrics, Centre of Paediatrics and Neonatology, Asklepios Clinics, Sankt Augustin, Germany. Funded and supported by resources from Mitogen Advanced Diagnostics Laboratory, the Dawson Jarrock Research Award (Calgary, Alberta, Canada) administered by the Alberta Children’s Foundation/Alberta Children’s Hospital Research Institute, and funds allocated to the Arthritis Society Research Chair by the University of Calgary, Division of Rheumatology, University of Calgary. M. Fritzler is a paid consultant, has received honoraria or gifts in kind from ImmunoConcepts Inc. and Inova Diagnostics Inc. M. Mahler is an employee of Inova Diagnostics Inc., a manufacturer of autoantibody diagnostic kits. H. Schmeling, MD, Department of Paediatrics, Alberta Children’s Hospital, University of Calgary, and Alberta Children’s Hospital Research Institute, and McCaig Institute for Bone and Joint Health; M. Mahler, PhD, Inova Diagnostics Inc.; D.M. Levy, PhD, Hospital for Sick Children, and University of Toronto; K. Moore, MD, Seattle Children’s Research Institute, Department of Pediatrics, University of Washington; A.M. Stevens, MD, PhD, Seattle Children’s Research Institute, Department of Pediatrics, University of Washington; J. Wick, BSc, Faculty of Medicine, University of Calgary; J.D. McMillan, Faculty of Medicine, University of Calgary; G. Horneff, MD, Department of General Paediatrics, Centre of Paediatrics and Neonatology, Asklepios Clinics; S. Assassi, MD, Division of Rheumatology, University of Texas Houston Medical School; J. Charles, BSc, MSc, Division of Rheumatology, University of Texas Houston Medical School; G. Salazar, MD, Division of Rheumatology, University of Texas Houston Medical School; M.D. Mayes, MD, MPH, Division of Rheumatology, University of Texas Houston Medical School; E.D. Silverman, MD, Hospital for Sick Children, and University of Toronto; M. Klien-Gitelman, MD, MPH, Northwestern University/Lurie Children’s Hospital; T. Lee, MD, Stanford University/ Lucile Packard Children’s Hospital; H.I. Brunner, MD, University of Cincinnati, and Cincinnati Children’s Hospital and Medical Center; A.M. Reed, MD, Department of Pediatrics, Duke University; M.J. Fritzler, MD, PhD, Faculty of Medicine, University of Calgary. Address correspondence to Dr. M.J. Fritzler, Cumming School of Medicine, University of Calgary, 3330 Hospital Dr. NW, Calgary, Alberta T2N 4N1, Canada. E-mail: fritzler@ucalgary.ca. Accepted for publication July 30, 2015.
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The Journal of Rheumatology
Vol. 51, Issue 4
1 Apr 2024
Autoantibodies to Dense Fine Speckles in Pediatric Diseases and Controls
Heinrike Schmeling, Michael Mahler, Deborah M. Levy, Katharine Moore, Anne M. Stevens, James Wick, Jacob D. McMillan, Gerd Horneff, Shervin Assassi, Julio Charles, Gloria Salazar, Maureen D. Mayes, Earl D. Silverman, Marissa Klien-Gitelman, Tzelan Lee, Hermine I. Brunner, Ann M. Reed, Marvin J. Fritzler
The Journal of Rheumatology Oct 2015, jrheum.150567; DOI: 10.3899/jrheum.150567
Autoantibodies to Dense Fine Speckles in Pediatric Diseases and Controls
Heinrike Schmeling, Michael Mahler, Deborah M. Levy, Katharine Moore, Anne M. Stevens, James Wick, Jacob D. McMillan, Gerd Horneff, Shervin Assassi, Julio Charles, Gloria Salazar, Maureen D. Mayes, Earl D. Silverman, Marissa Klien-Gitelman, Tzelan Lee, Hermine I. Brunner, Ann M. Reed, Marvin J. Fritzler
The Journal of Rheumatology Oct 2015, jrheum.150567; DOI: 10.3899/jrheum.150567