Research ArticleArticle
Downregulation of Tryptophan-related Metabolomic Profile in Rheumatoid Arthritis Synovial Fluid
Kwi Young Kang, Soo Hyun Lee, Seung Min Jung, Sung-Hwan Park, Byung-Hwa Jung and Ji Hyeon Ju
The Journal of Rheumatology September 2015, jrheum.141505; DOI: https://doi.org/10.3899/jrheum.141505
Kwi Young Kang
From the Division of Rheumatology, Department of Internal Medicine, College of Medicine, The Catholic University of Korea, Seoul; Division of Rheumatology, Department of Internal Medicine, College of Medicine, Incheon Saint Mary’s Hospital, The Catholic University of Korea, Incheon; Department of Medical Records and Health Information Management, College of Nursing and Health, Kongju National University, Chungnam; Molecular Recognition Research Center, Korea Institute of Science and Technology, Seoul; Division of Biological Chemistry, University of Science and Technology, Daejeon, South Korea. Supported by a grant from the Korea Healthcare Technology R&D Project, Ministry for Health, Welfare and Family Affairs, Republic of Korea (A092258), a Creative Allied Project funded by the Korea Research Council of Fundamental Science and Technology (CAP-12-1), and the Korea Institute of Science and Technology (KIST, 2E24860), and the Bio-Synergy Research Project (NRF-2013M3A9C4078145) of the Ministry of Science, ICT and Future Planning through the National Research Foundation. K.Y. Kang, PhD, Division of Rheumatology, Department of Internal Medicine, College of Medicine, The Catholic University of Korea, Division of Rheumatology, Department of Internal Medicine, College of Medicine, Incheon Saint Mary’s Hospital, The Catholic University of Korea; S.H. Lee, PhD, Department of Medical Records and Health Information Management, College of Nursing and Health, Kongju National University; S.M. Jung, MD; S.H. Park, PhD, Division of Rheumatology, Department of Internal Medicine, College of Medicine, The Catholic University of Korea; B.H. Jung, PhD, Molecular Recognition Research Center, Korea Institute of Science and Technology, Division of Biological Chemistry, University of Science and Technology; J.H. Ju, PhD, Division of Rheumatology, Department of Internal Medicine, College of Medicine, The Catholic University of Korea. K.Y. Kang and S.H. Lee contributed equally to this manuscript as first authors. B.H. Jung and J.H. Ju are both corresponding authors. Address correspondence to J.H. Ju, Division of Rheumatology, Department of Internal Medicine, College of Medicine, Seoul St. Mary’s Hospital, The Catholic University of Korea, #505, Banpo-Dong, Seocho-Gu, Seoul 137-701, South Korea. E-mail: juji@catholic.ac.kr.; or B.H. Jung, Molecular Recognition Research Center, Korea Institute of Science and Technology, Hwarangro 14-gil 5, Seongbuk-gu, Seoul 136-791, South Korea. E-mail: jbhluck@kist.re.kr. Accepted for publication June 8, 2015.
Soo Hyun Lee
From the Division of Rheumatology, Department of Internal Medicine, College of Medicine, The Catholic University of Korea, Seoul; Division of Rheumatology, Department of Internal Medicine, College of Medicine, Incheon Saint Mary’s Hospital, The Catholic University of Korea, Incheon; Department of Medical Records and Health Information Management, College of Nursing and Health, Kongju National University, Chungnam; Molecular Recognition Research Center, Korea Institute of Science and Technology, Seoul; Division of Biological Chemistry, University of Science and Technology, Daejeon, South Korea. Supported by a grant from the Korea Healthcare Technology R&D Project, Ministry for Health, Welfare and Family Affairs, Republic of Korea (A092258), a Creative Allied Project funded by the Korea Research Council of Fundamental Science and Technology (CAP-12-1), and the Korea Institute of Science and Technology (KIST, 2E24860), and the Bio-Synergy Research Project (NRF-2013M3A9C4078145) of the Ministry of Science, ICT and Future Planning through the National Research Foundation. K.Y. Kang, PhD, Division of Rheumatology, Department of Internal Medicine, College of Medicine, The Catholic University of Korea, Division of Rheumatology, Department of Internal Medicine, College of Medicine, Incheon Saint Mary’s Hospital, The Catholic University of Korea; S.H. Lee, PhD, Department of Medical Records and Health Information Management, College of Nursing and Health, Kongju National University; S.M. Jung, MD; S.H. Park, PhD, Division of Rheumatology, Department of Internal Medicine, College of Medicine, The Catholic University of Korea; B.H. Jung, PhD, Molecular Recognition Research Center, Korea Institute of Science and Technology, Division of Biological Chemistry, University of Science and Technology; J.H. Ju, PhD, Division of Rheumatology, Department of Internal Medicine, College of Medicine, The Catholic University of Korea. K.Y. Kang and S.H. Lee contributed equally to this manuscript as first authors. B.H. Jung and J.H. Ju are both corresponding authors. Address correspondence to J.H. Ju, Division of Rheumatology, Department of Internal Medicine, College of Medicine, Seoul St. Mary’s Hospital, The Catholic University of Korea, #505, Banpo-Dong, Seocho-Gu, Seoul 137-701, South Korea. E-mail: juji@catholic.ac.kr.; or B.H. Jung, Molecular Recognition Research Center, Korea Institute of Science and Technology, Hwarangro 14-gil 5, Seongbuk-gu, Seoul 136-791, South Korea. E-mail: jbhluck@kist.re.kr. Accepted for publication June 8, 2015.
Seung Min Jung
From the Division of Rheumatology, Department of Internal Medicine, College of Medicine, The Catholic University of Korea, Seoul; Division of Rheumatology, Department of Internal Medicine, College of Medicine, Incheon Saint Mary’s Hospital, The Catholic University of Korea, Incheon; Department of Medical Records and Health Information Management, College of Nursing and Health, Kongju National University, Chungnam; Molecular Recognition Research Center, Korea Institute of Science and Technology, Seoul; Division of Biological Chemistry, University of Science and Technology, Daejeon, South Korea. Supported by a grant from the Korea Healthcare Technology R&D Project, Ministry for Health, Welfare and Family Affairs, Republic of Korea (A092258), a Creative Allied Project funded by the Korea Research Council of Fundamental Science and Technology (CAP-12-1), and the Korea Institute of Science and Technology (KIST, 2E24860), and the Bio-Synergy Research Project (NRF-2013M3A9C4078145) of the Ministry of Science, ICT and Future Planning through the National Research Foundation. K.Y. Kang, PhD, Division of Rheumatology, Department of Internal Medicine, College of Medicine, The Catholic University of Korea, Division of Rheumatology, Department of Internal Medicine, College of Medicine, Incheon Saint Mary’s Hospital, The Catholic University of Korea; S.H. Lee, PhD, Department of Medical Records and Health Information Management, College of Nursing and Health, Kongju National University; S.M. Jung, MD; S.H. Park, PhD, Division of Rheumatology, Department of Internal Medicine, College of Medicine, The Catholic University of Korea; B.H. Jung, PhD, Molecular Recognition Research Center, Korea Institute of Science and Technology, Division of Biological Chemistry, University of Science and Technology; J.H. Ju, PhD, Division of Rheumatology, Department of Internal Medicine, College of Medicine, The Catholic University of Korea. K.Y. Kang and S.H. Lee contributed equally to this manuscript as first authors. B.H. Jung and J.H. Ju are both corresponding authors. Address correspondence to J.H. Ju, Division of Rheumatology, Department of Internal Medicine, College of Medicine, Seoul St. Mary’s Hospital, The Catholic University of Korea, #505, Banpo-Dong, Seocho-Gu, Seoul 137-701, South Korea. E-mail: juji@catholic.ac.kr.; or B.H. Jung, Molecular Recognition Research Center, Korea Institute of Science and Technology, Hwarangro 14-gil 5, Seongbuk-gu, Seoul 136-791, South Korea. E-mail: jbhluck@kist.re.kr. Accepted for publication June 8, 2015.
Sung-Hwan Park
From the Division of Rheumatology, Department of Internal Medicine, College of Medicine, The Catholic University of Korea, Seoul; Division of Rheumatology, Department of Internal Medicine, College of Medicine, Incheon Saint Mary’s Hospital, The Catholic University of Korea, Incheon; Department of Medical Records and Health Information Management, College of Nursing and Health, Kongju National University, Chungnam; Molecular Recognition Research Center, Korea Institute of Science and Technology, Seoul; Division of Biological Chemistry, University of Science and Technology, Daejeon, South Korea. Supported by a grant from the Korea Healthcare Technology R&D Project, Ministry for Health, Welfare and Family Affairs, Republic of Korea (A092258), a Creative Allied Project funded by the Korea Research Council of Fundamental Science and Technology (CAP-12-1), and the Korea Institute of Science and Technology (KIST, 2E24860), and the Bio-Synergy Research Project (NRF-2013M3A9C4078145) of the Ministry of Science, ICT and Future Planning through the National Research Foundation. K.Y. Kang, PhD, Division of Rheumatology, Department of Internal Medicine, College of Medicine, The Catholic University of Korea, Division of Rheumatology, Department of Internal Medicine, College of Medicine, Incheon Saint Mary’s Hospital, The Catholic University of Korea; S.H. Lee, PhD, Department of Medical Records and Health Information Management, College of Nursing and Health, Kongju National University; S.M. Jung, MD; S.H. Park, PhD, Division of Rheumatology, Department of Internal Medicine, College of Medicine, The Catholic University of Korea; B.H. Jung, PhD, Molecular Recognition Research Center, Korea Institute of Science and Technology, Division of Biological Chemistry, University of Science and Technology; J.H. Ju, PhD, Division of Rheumatology, Department of Internal Medicine, College of Medicine, The Catholic University of Korea. K.Y. Kang and S.H. Lee contributed equally to this manuscript as first authors. B.H. Jung and J.H. Ju are both corresponding authors. Address correspondence to J.H. Ju, Division of Rheumatology, Department of Internal Medicine, College of Medicine, Seoul St. Mary’s Hospital, The Catholic University of Korea, #505, Banpo-Dong, Seocho-Gu, Seoul 137-701, South Korea. E-mail: juji@catholic.ac.kr.; or B.H. Jung, Molecular Recognition Research Center, Korea Institute of Science and Technology, Hwarangro 14-gil 5, Seongbuk-gu, Seoul 136-791, South Korea. E-mail: jbhluck@kist.re.kr. Accepted for publication June 8, 2015.
Byung-Hwa Jung
From the Division of Rheumatology, Department of Internal Medicine, College of Medicine, The Catholic University of Korea, Seoul; Division of Rheumatology, Department of Internal Medicine, College of Medicine, Incheon Saint Mary’s Hospital, The Catholic University of Korea, Incheon; Department of Medical Records and Health Information Management, College of Nursing and Health, Kongju National University, Chungnam; Molecular Recognition Research Center, Korea Institute of Science and Technology, Seoul; Division of Biological Chemistry, University of Science and Technology, Daejeon, South Korea. Supported by a grant from the Korea Healthcare Technology R&D Project, Ministry for Health, Welfare and Family Affairs, Republic of Korea (A092258), a Creative Allied Project funded by the Korea Research Council of Fundamental Science and Technology (CAP-12-1), and the Korea Institute of Science and Technology (KIST, 2E24860), and the Bio-Synergy Research Project (NRF-2013M3A9C4078145) of the Ministry of Science, ICT and Future Planning through the National Research Foundation. K.Y. Kang, PhD, Division of Rheumatology, Department of Internal Medicine, College of Medicine, The Catholic University of Korea, Division of Rheumatology, Department of Internal Medicine, College of Medicine, Incheon Saint Mary’s Hospital, The Catholic University of Korea; S.H. Lee, PhD, Department of Medical Records and Health Information Management, College of Nursing and Health, Kongju National University; S.M. Jung, MD; S.H. Park, PhD, Division of Rheumatology, Department of Internal Medicine, College of Medicine, The Catholic University of Korea; B.H. Jung, PhD, Molecular Recognition Research Center, Korea Institute of Science and Technology, Division of Biological Chemistry, University of Science and Technology; J.H. Ju, PhD, Division of Rheumatology, Department of Internal Medicine, College of Medicine, The Catholic University of Korea. K.Y. Kang and S.H. Lee contributed equally to this manuscript as first authors. B.H. Jung and J.H. Ju are both corresponding authors. Address correspondence to J.H. Ju, Division of Rheumatology, Department of Internal Medicine, College of Medicine, Seoul St. Mary’s Hospital, The Catholic University of Korea, #505, Banpo-Dong, Seocho-Gu, Seoul 137-701, South Korea. E-mail: juji@catholic.ac.kr.; or B.H. Jung, Molecular Recognition Research Center, Korea Institute of Science and Technology, Hwarangro 14-gil 5, Seongbuk-gu, Seoul 136-791, South Korea. E-mail: jbhluck@kist.re.kr. Accepted for publication June 8, 2015.
Ji Hyeon Ju
From the Division of Rheumatology, Department of Internal Medicine, College of Medicine, The Catholic University of Korea, Seoul; Division of Rheumatology, Department of Internal Medicine, College of Medicine, Incheon Saint Mary’s Hospital, The Catholic University of Korea, Incheon; Department of Medical Records and Health Information Management, College of Nursing and Health, Kongju National University, Chungnam; Molecular Recognition Research Center, Korea Institute of Science and Technology, Seoul; Division of Biological Chemistry, University of Science and Technology, Daejeon, South Korea. Supported by a grant from the Korea Healthcare Technology R&D Project, Ministry for Health, Welfare and Family Affairs, Republic of Korea (A092258), a Creative Allied Project funded by the Korea Research Council of Fundamental Science and Technology (CAP-12-1), and the Korea Institute of Science and Technology (KIST, 2E24860), and the Bio-Synergy Research Project (NRF-2013M3A9C4078145) of the Ministry of Science, ICT and Future Planning through the National Research Foundation. K.Y. Kang, PhD, Division of Rheumatology, Department of Internal Medicine, College of Medicine, The Catholic University of Korea, Division of Rheumatology, Department of Internal Medicine, College of Medicine, Incheon Saint Mary’s Hospital, The Catholic University of Korea; S.H. Lee, PhD, Department of Medical Records and Health Information Management, College of Nursing and Health, Kongju National University; S.M. Jung, MD; S.H. Park, PhD, Division of Rheumatology, Department of Internal Medicine, College of Medicine, The Catholic University of Korea; B.H. Jung, PhD, Molecular Recognition Research Center, Korea Institute of Science and Technology, Division of Biological Chemistry, University of Science and Technology; J.H. Ju, PhD, Division of Rheumatology, Department of Internal Medicine, College of Medicine, The Catholic University of Korea. K.Y. Kang and S.H. Lee contributed equally to this manuscript as first authors. B.H. Jung and J.H. Ju are both corresponding authors. Address correspondence to J.H. Ju, Division of Rheumatology, Department of Internal Medicine, College of Medicine, Seoul St. Mary’s Hospital, The Catholic University of Korea, #505, Banpo-Dong, Seocho-Gu, Seoul 137-701, South Korea. E-mail: juji@catholic.ac.kr.; or B.H. Jung, Molecular Recognition Research Center, Korea Institute of Science and Technology, Hwarangro 14-gil 5, Seongbuk-gu, Seoul 136-791, South Korea. E-mail: jbhluck@kist.re.kr. Accepted for publication June 8, 2015.
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The Journal of Rheumatology
Vol. 51, Issue 3
1 Mar 2024
Downregulation of Tryptophan-related Metabolomic Profile in Rheumatoid Arthritis Synovial Fluid
Kwi Young Kang, Soo Hyun Lee, Seung Min Jung, Sung-Hwan Park, Byung-Hwa Jung, Ji Hyeon Ju
The Journal of Rheumatology Sep 2015, jrheum.141505; DOI: 10.3899/jrheum.141505