Research ArticleArticle
Nuclear Factor-κB–inducing Kinase Is Expressed in Synovial Endothelial Cells in Patients with Early Arthritis and Correlates with Markers of Inflammation: A Prospective Cohort Study
Karen I. Maijer, Ae Ri Noort, Maria J.H. de Hair, Christiaan van der Leij, Katinka P.M. van Zoest, Ivy Y. Choi, Daniëlle M. Gerlag, Mario Maas, Paul P. Tak and Sander W. Tas
The Journal of Rheumatology July 2015, jrheum.150245; DOI: https://doi.org/10.3899/jrheum.150245
Karen I. Maijer
From the Division of Clinical Immunology and Rheumatology, the Department of Experimental Immunology, and the Department of Radiology, Academic Medical Center/University of Amsterdam, Amsterdam, the Netherlands; GlaxoSmithKline, Stevenage; University of Cambridge, Cambridge, UK. Supported by the Dutch Arthritis Foundation (grant number 06-1-303, 11-1-407, 12-2-050), the Netherlands Organization for Health Research and Development (ZonMw; grant number 200310003), a Veni grant of the Netherlands Organization for Scientific Research (NHW; grant number 91696015), a Clinical Fellowship (ZonMw; grant number 90700359) to SWT, the Innovative Medicines Initiative European Union funded project BeTheCure (grant number 115142), and the European Union Seventh Framework Programme (project EuroTEAM; FP7-HEALTHF2-2012; grant number 305549). K.I. Maijer, MD, Division of Clinical Immunology and Rheumatology, Academic Medical Center/University of Amsterdam; A.R. Noort, MSc, Division of Clinical Immunology and Rheumatology, and Department of Experimental Immunology, Academic Medical Center/University of Amsterdam; M.J. de Hair, MD, PhD, Division of Clinical Immunology and Rheumatology, Academic Medical Center/University of Amsterdam; C. van der Leij, MD, Department of Radiology, Academic Medical Center/University of Amsterdam; K.P. van Zoest, BSc, Division of Clinical Immunology and Rheumatology, and Department of Experimental Immunology, Academic Medical Center/University of Amsterdam; I.Y. Choi, MD, Division of Clinical Immunology and Rheumatology, Academic Medical Center/University of Amsterdam; D.M. Gerlag, MD, PhD, Division of Clinical Immunology and Rheumatology, Academic Medical Center/University of Amsterdam, and GlaxoSmithKline; M. Maas, MD, PhD, Department of Radiology, Academic Medical Center/University of Amsterdam; P.P. Tak, MD, PhD, Division of Clinical Immunology and Rheumatology, Academic Medical Center/University of Amsterdam, and GlaxoSmithKline, Stevenage, and University of Cambridge; S.W. Tas, MD, PhD, Division of Clinical Immunology and Rheumatology, and Department of Experimental Immunology, Academic Medical Center/University of Amsterdam. K.I. Maijer and A.R. Noort are shared first authors of this manuscript. Address correspondence to Dr. S.W. Tas, Division of Clinical Immunology and Rheumatology, Department of Internal Medicine, Academic Medical Center/University of Amsterdam, Meibergdreef 9, 1105 AZ, Amsterdam, the Netherlands. E-mail: s.w.tas@amc.uva.nl. Accepted for publication May 27, 2015.
Ae Ri Noort
From the Division of Clinical Immunology and Rheumatology, the Department of Experimental Immunology, and the Department of Radiology, Academic Medical Center/University of Amsterdam, Amsterdam, the Netherlands; GlaxoSmithKline, Stevenage; University of Cambridge, Cambridge, UK. Supported by the Dutch Arthritis Foundation (grant number 06-1-303, 11-1-407, 12-2-050), the Netherlands Organization for Health Research and Development (ZonMw; grant number 200310003), a Veni grant of the Netherlands Organization for Scientific Research (NHW; grant number 91696015), a Clinical Fellowship (ZonMw; grant number 90700359) to SWT, the Innovative Medicines Initiative European Union funded project BeTheCure (grant number 115142), and the European Union Seventh Framework Programme (project EuroTEAM; FP7-HEALTHF2-2012; grant number 305549). K.I. Maijer, MD, Division of Clinical Immunology and Rheumatology, Academic Medical Center/University of Amsterdam; A.R. Noort, MSc, Division of Clinical Immunology and Rheumatology, and Department of Experimental Immunology, Academic Medical Center/University of Amsterdam; M.J. de Hair, MD, PhD, Division of Clinical Immunology and Rheumatology, Academic Medical Center/University of Amsterdam; C. van der Leij, MD, Department of Radiology, Academic Medical Center/University of Amsterdam; K.P. van Zoest, BSc, Division of Clinical Immunology and Rheumatology, and Department of Experimental Immunology, Academic Medical Center/University of Amsterdam; I.Y. Choi, MD, Division of Clinical Immunology and Rheumatology, Academic Medical Center/University of Amsterdam; D.M. Gerlag, MD, PhD, Division of Clinical Immunology and Rheumatology, Academic Medical Center/University of Amsterdam, and GlaxoSmithKline; M. Maas, MD, PhD, Department of Radiology, Academic Medical Center/University of Amsterdam; P.P. Tak, MD, PhD, Division of Clinical Immunology and Rheumatology, Academic Medical Center/University of Amsterdam, and GlaxoSmithKline, Stevenage, and University of Cambridge; S.W. Tas, MD, PhD, Division of Clinical Immunology and Rheumatology, and Department of Experimental Immunology, Academic Medical Center/University of Amsterdam. K.I. Maijer and A.R. Noort are shared first authors of this manuscript. Address correspondence to Dr. S.W. Tas, Division of Clinical Immunology and Rheumatology, Department of Internal Medicine, Academic Medical Center/University of Amsterdam, Meibergdreef 9, 1105 AZ, Amsterdam, the Netherlands. E-mail: s.w.tas@amc.uva.nl. Accepted for publication May 27, 2015.
Maria J.H. de Hair
From the Division of Clinical Immunology and Rheumatology, the Department of Experimental Immunology, and the Department of Radiology, Academic Medical Center/University of Amsterdam, Amsterdam, the Netherlands; GlaxoSmithKline, Stevenage; University of Cambridge, Cambridge, UK. Supported by the Dutch Arthritis Foundation (grant number 06-1-303, 11-1-407, 12-2-050), the Netherlands Organization for Health Research and Development (ZonMw; grant number 200310003), a Veni grant of the Netherlands Organization for Scientific Research (NHW; grant number 91696015), a Clinical Fellowship (ZonMw; grant number 90700359) to SWT, the Innovative Medicines Initiative European Union funded project BeTheCure (grant number 115142), and the European Union Seventh Framework Programme (project EuroTEAM; FP7-HEALTHF2-2012; grant number 305549). K.I. Maijer, MD, Division of Clinical Immunology and Rheumatology, Academic Medical Center/University of Amsterdam; A.R. Noort, MSc, Division of Clinical Immunology and Rheumatology, and Department of Experimental Immunology, Academic Medical Center/University of Amsterdam; M.J. de Hair, MD, PhD, Division of Clinical Immunology and Rheumatology, Academic Medical Center/University of Amsterdam; C. van der Leij, MD, Department of Radiology, Academic Medical Center/University of Amsterdam; K.P. van Zoest, BSc, Division of Clinical Immunology and Rheumatology, and Department of Experimental Immunology, Academic Medical Center/University of Amsterdam; I.Y. Choi, MD, Division of Clinical Immunology and Rheumatology, Academic Medical Center/University of Amsterdam; D.M. Gerlag, MD, PhD, Division of Clinical Immunology and Rheumatology, Academic Medical Center/University of Amsterdam, and GlaxoSmithKline; M. Maas, MD, PhD, Department of Radiology, Academic Medical Center/University of Amsterdam; P.P. Tak, MD, PhD, Division of Clinical Immunology and Rheumatology, Academic Medical Center/University of Amsterdam, and GlaxoSmithKline, Stevenage, and University of Cambridge; S.W. Tas, MD, PhD, Division of Clinical Immunology and Rheumatology, and Department of Experimental Immunology, Academic Medical Center/University of Amsterdam. K.I. Maijer and A.R. Noort are shared first authors of this manuscript. Address correspondence to Dr. S.W. Tas, Division of Clinical Immunology and Rheumatology, Department of Internal Medicine, Academic Medical Center/University of Amsterdam, Meibergdreef 9, 1105 AZ, Amsterdam, the Netherlands. E-mail: s.w.tas@amc.uva.nl. Accepted for publication May 27, 2015.
Christiaan van der Leij
From the Division of Clinical Immunology and Rheumatology, the Department of Experimental Immunology, and the Department of Radiology, Academic Medical Center/University of Amsterdam, Amsterdam, the Netherlands; GlaxoSmithKline, Stevenage; University of Cambridge, Cambridge, UK. Supported by the Dutch Arthritis Foundation (grant number 06-1-303, 11-1-407, 12-2-050), the Netherlands Organization for Health Research and Development (ZonMw; grant number 200310003), a Veni grant of the Netherlands Organization for Scientific Research (NHW; grant number 91696015), a Clinical Fellowship (ZonMw; grant number 90700359) to SWT, the Innovative Medicines Initiative European Union funded project BeTheCure (grant number 115142), and the European Union Seventh Framework Programme (project EuroTEAM; FP7-HEALTHF2-2012; grant number 305549). K.I. Maijer, MD, Division of Clinical Immunology and Rheumatology, Academic Medical Center/University of Amsterdam; A.R. Noort, MSc, Division of Clinical Immunology and Rheumatology, and Department of Experimental Immunology, Academic Medical Center/University of Amsterdam; M.J. de Hair, MD, PhD, Division of Clinical Immunology and Rheumatology, Academic Medical Center/University of Amsterdam; C. van der Leij, MD, Department of Radiology, Academic Medical Center/University of Amsterdam; K.P. van Zoest, BSc, Division of Clinical Immunology and Rheumatology, and Department of Experimental Immunology, Academic Medical Center/University of Amsterdam; I.Y. Choi, MD, Division of Clinical Immunology and Rheumatology, Academic Medical Center/University of Amsterdam; D.M. Gerlag, MD, PhD, Division of Clinical Immunology and Rheumatology, Academic Medical Center/University of Amsterdam, and GlaxoSmithKline; M. Maas, MD, PhD, Department of Radiology, Academic Medical Center/University of Amsterdam; P.P. Tak, MD, PhD, Division of Clinical Immunology and Rheumatology, Academic Medical Center/University of Amsterdam, and GlaxoSmithKline, Stevenage, and University of Cambridge; S.W. Tas, MD, PhD, Division of Clinical Immunology and Rheumatology, and Department of Experimental Immunology, Academic Medical Center/University of Amsterdam. K.I. Maijer and A.R. Noort are shared first authors of this manuscript. Address correspondence to Dr. S.W. Tas, Division of Clinical Immunology and Rheumatology, Department of Internal Medicine, Academic Medical Center/University of Amsterdam, Meibergdreef 9, 1105 AZ, Amsterdam, the Netherlands. E-mail: s.w.tas@amc.uva.nl. Accepted for publication May 27, 2015.
Katinka P.M. van Zoest
From the Division of Clinical Immunology and Rheumatology, the Department of Experimental Immunology, and the Department of Radiology, Academic Medical Center/University of Amsterdam, Amsterdam, the Netherlands; GlaxoSmithKline, Stevenage; University of Cambridge, Cambridge, UK. Supported by the Dutch Arthritis Foundation (grant number 06-1-303, 11-1-407, 12-2-050), the Netherlands Organization for Health Research and Development (ZonMw; grant number 200310003), a Veni grant of the Netherlands Organization for Scientific Research (NHW; grant number 91696015), a Clinical Fellowship (ZonMw; grant number 90700359) to SWT, the Innovative Medicines Initiative European Union funded project BeTheCure (grant number 115142), and the European Union Seventh Framework Programme (project EuroTEAM; FP7-HEALTHF2-2012; grant number 305549). K.I. Maijer, MD, Division of Clinical Immunology and Rheumatology, Academic Medical Center/University of Amsterdam; A.R. Noort, MSc, Division of Clinical Immunology and Rheumatology, and Department of Experimental Immunology, Academic Medical Center/University of Amsterdam; M.J. de Hair, MD, PhD, Division of Clinical Immunology and Rheumatology, Academic Medical Center/University of Amsterdam; C. van der Leij, MD, Department of Radiology, Academic Medical Center/University of Amsterdam; K.P. van Zoest, BSc, Division of Clinical Immunology and Rheumatology, and Department of Experimental Immunology, Academic Medical Center/University of Amsterdam; I.Y. Choi, MD, Division of Clinical Immunology and Rheumatology, Academic Medical Center/University of Amsterdam; D.M. Gerlag, MD, PhD, Division of Clinical Immunology and Rheumatology, Academic Medical Center/University of Amsterdam, and GlaxoSmithKline; M. Maas, MD, PhD, Department of Radiology, Academic Medical Center/University of Amsterdam; P.P. Tak, MD, PhD, Division of Clinical Immunology and Rheumatology, Academic Medical Center/University of Amsterdam, and GlaxoSmithKline, Stevenage, and University of Cambridge; S.W. Tas, MD, PhD, Division of Clinical Immunology and Rheumatology, and Department of Experimental Immunology, Academic Medical Center/University of Amsterdam. K.I. Maijer and A.R. Noort are shared first authors of this manuscript. Address correspondence to Dr. S.W. Tas, Division of Clinical Immunology and Rheumatology, Department of Internal Medicine, Academic Medical Center/University of Amsterdam, Meibergdreef 9, 1105 AZ, Amsterdam, the Netherlands. E-mail: s.w.tas@amc.uva.nl. Accepted for publication May 27, 2015.
Ivy Y. Choi
From the Division of Clinical Immunology and Rheumatology, the Department of Experimental Immunology, and the Department of Radiology, Academic Medical Center/University of Amsterdam, Amsterdam, the Netherlands; GlaxoSmithKline, Stevenage; University of Cambridge, Cambridge, UK. Supported by the Dutch Arthritis Foundation (grant number 06-1-303, 11-1-407, 12-2-050), the Netherlands Organization for Health Research and Development (ZonMw; grant number 200310003), a Veni grant of the Netherlands Organization for Scientific Research (NHW; grant number 91696015), a Clinical Fellowship (ZonMw; grant number 90700359) to SWT, the Innovative Medicines Initiative European Union funded project BeTheCure (grant number 115142), and the European Union Seventh Framework Programme (project EuroTEAM; FP7-HEALTHF2-2012; grant number 305549). K.I. Maijer, MD, Division of Clinical Immunology and Rheumatology, Academic Medical Center/University of Amsterdam; A.R. Noort, MSc, Division of Clinical Immunology and Rheumatology, and Department of Experimental Immunology, Academic Medical Center/University of Amsterdam; M.J. de Hair, MD, PhD, Division of Clinical Immunology and Rheumatology, Academic Medical Center/University of Amsterdam; C. van der Leij, MD, Department of Radiology, Academic Medical Center/University of Amsterdam; K.P. van Zoest, BSc, Division of Clinical Immunology and Rheumatology, and Department of Experimental Immunology, Academic Medical Center/University of Amsterdam; I.Y. Choi, MD, Division of Clinical Immunology and Rheumatology, Academic Medical Center/University of Amsterdam; D.M. Gerlag, MD, PhD, Division of Clinical Immunology and Rheumatology, Academic Medical Center/University of Amsterdam, and GlaxoSmithKline; M. Maas, MD, PhD, Department of Radiology, Academic Medical Center/University of Amsterdam; P.P. Tak, MD, PhD, Division of Clinical Immunology and Rheumatology, Academic Medical Center/University of Amsterdam, and GlaxoSmithKline, Stevenage, and University of Cambridge; S.W. Tas, MD, PhD, Division of Clinical Immunology and Rheumatology, and Department of Experimental Immunology, Academic Medical Center/University of Amsterdam. K.I. Maijer and A.R. Noort are shared first authors of this manuscript. Address correspondence to Dr. S.W. Tas, Division of Clinical Immunology and Rheumatology, Department of Internal Medicine, Academic Medical Center/University of Amsterdam, Meibergdreef 9, 1105 AZ, Amsterdam, the Netherlands. E-mail: s.w.tas@amc.uva.nl. Accepted for publication May 27, 2015.
Daniëlle M. Gerlag
From the Division of Clinical Immunology and Rheumatology, the Department of Experimental Immunology, and the Department of Radiology, Academic Medical Center/University of Amsterdam, Amsterdam, the Netherlands; GlaxoSmithKline, Stevenage; University of Cambridge, Cambridge, UK. Supported by the Dutch Arthritis Foundation (grant number 06-1-303, 11-1-407, 12-2-050), the Netherlands Organization for Health Research and Development (ZonMw; grant number 200310003), a Veni grant of the Netherlands Organization for Scientific Research (NHW; grant number 91696015), a Clinical Fellowship (ZonMw; grant number 90700359) to SWT, the Innovative Medicines Initiative European Union funded project BeTheCure (grant number 115142), and the European Union Seventh Framework Programme (project EuroTEAM; FP7-HEALTHF2-2012; grant number 305549). K.I. Maijer, MD, Division of Clinical Immunology and Rheumatology, Academic Medical Center/University of Amsterdam; A.R. Noort, MSc, Division of Clinical Immunology and Rheumatology, and Department of Experimental Immunology, Academic Medical Center/University of Amsterdam; M.J. de Hair, MD, PhD, Division of Clinical Immunology and Rheumatology, Academic Medical Center/University of Amsterdam; C. van der Leij, MD, Department of Radiology, Academic Medical Center/University of Amsterdam; K.P. van Zoest, BSc, Division of Clinical Immunology and Rheumatology, and Department of Experimental Immunology, Academic Medical Center/University of Amsterdam; I.Y. Choi, MD, Division of Clinical Immunology and Rheumatology, Academic Medical Center/University of Amsterdam; D.M. Gerlag, MD, PhD, Division of Clinical Immunology and Rheumatology, Academic Medical Center/University of Amsterdam, and GlaxoSmithKline; M. Maas, MD, PhD, Department of Radiology, Academic Medical Center/University of Amsterdam; P.P. Tak, MD, PhD, Division of Clinical Immunology and Rheumatology, Academic Medical Center/University of Amsterdam, and GlaxoSmithKline, Stevenage, and University of Cambridge; S.W. Tas, MD, PhD, Division of Clinical Immunology and Rheumatology, and Department of Experimental Immunology, Academic Medical Center/University of Amsterdam. K.I. Maijer and A.R. Noort are shared first authors of this manuscript. Address correspondence to Dr. S.W. Tas, Division of Clinical Immunology and Rheumatology, Department of Internal Medicine, Academic Medical Center/University of Amsterdam, Meibergdreef 9, 1105 AZ, Amsterdam, the Netherlands. E-mail: s.w.tas@amc.uva.nl. Accepted for publication May 27, 2015.
Mario Maas
From the Division of Clinical Immunology and Rheumatology, the Department of Experimental Immunology, and the Department of Radiology, Academic Medical Center/University of Amsterdam, Amsterdam, the Netherlands; GlaxoSmithKline, Stevenage; University of Cambridge, Cambridge, UK. Supported by the Dutch Arthritis Foundation (grant number 06-1-303, 11-1-407, 12-2-050), the Netherlands Organization for Health Research and Development (ZonMw; grant number 200310003), a Veni grant of the Netherlands Organization for Scientific Research (NHW; grant number 91696015), a Clinical Fellowship (ZonMw; grant number 90700359) to SWT, the Innovative Medicines Initiative European Union funded project BeTheCure (grant number 115142), and the European Union Seventh Framework Programme (project EuroTEAM; FP7-HEALTHF2-2012; grant number 305549). K.I. Maijer, MD, Division of Clinical Immunology and Rheumatology, Academic Medical Center/University of Amsterdam; A.R. Noort, MSc, Division of Clinical Immunology and Rheumatology, and Department of Experimental Immunology, Academic Medical Center/University of Amsterdam; M.J. de Hair, MD, PhD, Division of Clinical Immunology and Rheumatology, Academic Medical Center/University of Amsterdam; C. van der Leij, MD, Department of Radiology, Academic Medical Center/University of Amsterdam; K.P. van Zoest, BSc, Division of Clinical Immunology and Rheumatology, and Department of Experimental Immunology, Academic Medical Center/University of Amsterdam; I.Y. Choi, MD, Division of Clinical Immunology and Rheumatology, Academic Medical Center/University of Amsterdam; D.M. Gerlag, MD, PhD, Division of Clinical Immunology and Rheumatology, Academic Medical Center/University of Amsterdam, and GlaxoSmithKline; M. Maas, MD, PhD, Department of Radiology, Academic Medical Center/University of Amsterdam; P.P. Tak, MD, PhD, Division of Clinical Immunology and Rheumatology, Academic Medical Center/University of Amsterdam, and GlaxoSmithKline, Stevenage, and University of Cambridge; S.W. Tas, MD, PhD, Division of Clinical Immunology and Rheumatology, and Department of Experimental Immunology, Academic Medical Center/University of Amsterdam. K.I. Maijer and A.R. Noort are shared first authors of this manuscript. Address correspondence to Dr. S.W. Tas, Division of Clinical Immunology and Rheumatology, Department of Internal Medicine, Academic Medical Center/University of Amsterdam, Meibergdreef 9, 1105 AZ, Amsterdam, the Netherlands. E-mail: s.w.tas@amc.uva.nl. Accepted for publication May 27, 2015.
Paul P. Tak
From the Division of Clinical Immunology and Rheumatology, the Department of Experimental Immunology, and the Department of Radiology, Academic Medical Center/University of Amsterdam, Amsterdam, the Netherlands; GlaxoSmithKline, Stevenage; University of Cambridge, Cambridge, UK. Supported by the Dutch Arthritis Foundation (grant number 06-1-303, 11-1-407, 12-2-050), the Netherlands Organization for Health Research and Development (ZonMw; grant number 200310003), a Veni grant of the Netherlands Organization for Scientific Research (NHW; grant number 91696015), a Clinical Fellowship (ZonMw; grant number 90700359) to SWT, the Innovative Medicines Initiative European Union funded project BeTheCure (grant number 115142), and the European Union Seventh Framework Programme (project EuroTEAM; FP7-HEALTHF2-2012; grant number 305549). K.I. Maijer, MD, Division of Clinical Immunology and Rheumatology, Academic Medical Center/University of Amsterdam; A.R. Noort, MSc, Division of Clinical Immunology and Rheumatology, and Department of Experimental Immunology, Academic Medical Center/University of Amsterdam; M.J. de Hair, MD, PhD, Division of Clinical Immunology and Rheumatology, Academic Medical Center/University of Amsterdam; C. van der Leij, MD, Department of Radiology, Academic Medical Center/University of Amsterdam; K.P. van Zoest, BSc, Division of Clinical Immunology and Rheumatology, and Department of Experimental Immunology, Academic Medical Center/University of Amsterdam; I.Y. Choi, MD, Division of Clinical Immunology and Rheumatology, Academic Medical Center/University of Amsterdam; D.M. Gerlag, MD, PhD, Division of Clinical Immunology and Rheumatology, Academic Medical Center/University of Amsterdam, and GlaxoSmithKline; M. Maas, MD, PhD, Department of Radiology, Academic Medical Center/University of Amsterdam; P.P. Tak, MD, PhD, Division of Clinical Immunology and Rheumatology, Academic Medical Center/University of Amsterdam, and GlaxoSmithKline, Stevenage, and University of Cambridge; S.W. Tas, MD, PhD, Division of Clinical Immunology and Rheumatology, and Department of Experimental Immunology, Academic Medical Center/University of Amsterdam. K.I. Maijer and A.R. Noort are shared first authors of this manuscript. Address correspondence to Dr. S.W. Tas, Division of Clinical Immunology and Rheumatology, Department of Internal Medicine, Academic Medical Center/University of Amsterdam, Meibergdreef 9, 1105 AZ, Amsterdam, the Netherlands. E-mail: s.w.tas@amc.uva.nl. Accepted for publication May 27, 2015.
Sander W. Tas
From the Division of Clinical Immunology and Rheumatology, the Department of Experimental Immunology, and the Department of Radiology, Academic Medical Center/University of Amsterdam, Amsterdam, the Netherlands; GlaxoSmithKline, Stevenage; University of Cambridge, Cambridge, UK. Supported by the Dutch Arthritis Foundation (grant number 06-1-303, 11-1-407, 12-2-050), the Netherlands Organization for Health Research and Development (ZonMw; grant number 200310003), a Veni grant of the Netherlands Organization for Scientific Research (NHW; grant number 91696015), a Clinical Fellowship (ZonMw; grant number 90700359) to SWT, the Innovative Medicines Initiative European Union funded project BeTheCure (grant number 115142), and the European Union Seventh Framework Programme (project EuroTEAM; FP7-HEALTHF2-2012; grant number 305549). K.I. Maijer, MD, Division of Clinical Immunology and Rheumatology, Academic Medical Center/University of Amsterdam; A.R. Noort, MSc, Division of Clinical Immunology and Rheumatology, and Department of Experimental Immunology, Academic Medical Center/University of Amsterdam; M.J. de Hair, MD, PhD, Division of Clinical Immunology and Rheumatology, Academic Medical Center/University of Amsterdam; C. van der Leij, MD, Department of Radiology, Academic Medical Center/University of Amsterdam; K.P. van Zoest, BSc, Division of Clinical Immunology and Rheumatology, and Department of Experimental Immunology, Academic Medical Center/University of Amsterdam; I.Y. Choi, MD, Division of Clinical Immunology and Rheumatology, Academic Medical Center/University of Amsterdam; D.M. Gerlag, MD, PhD, Division of Clinical Immunology and Rheumatology, Academic Medical Center/University of Amsterdam, and GlaxoSmithKline; M. Maas, MD, PhD, Department of Radiology, Academic Medical Center/University of Amsterdam; P.P. Tak, MD, PhD, Division of Clinical Immunology and Rheumatology, Academic Medical Center/University of Amsterdam, and GlaxoSmithKline, Stevenage, and University of Cambridge; S.W. Tas, MD, PhD, Division of Clinical Immunology and Rheumatology, and Department of Experimental Immunology, Academic Medical Center/University of Amsterdam. K.I. Maijer and A.R. Noort are shared first authors of this manuscript. Address correspondence to Dr. S.W. Tas, Division of Clinical Immunology and Rheumatology, Department of Internal Medicine, Academic Medical Center/University of Amsterdam, Meibergdreef 9, 1105 AZ, Amsterdam, the Netherlands. E-mail: s.w.tas@amc.uva.nl. Accepted for publication May 27, 2015.
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In this issue
The Journal of Rheumatology
Vol. 51, Issue 4
1 Apr 2024
Nuclear Factor-κB–inducing Kinase Is Expressed in Synovial Endothelial Cells in Patients with Early Arthritis and Correlates with Markers of Inflammation: A Prospective Cohort Study
Karen I. Maijer, Ae Ri Noort, Maria J.H. de Hair, Christiaan van der Leij, Katinka P.M. van Zoest, Ivy Y. Choi, Daniëlle M. Gerlag, Mario Maas, Paul P. Tak, Sander W. Tas
The Journal of Rheumatology Jul 2015, jrheum.150245; DOI: 10.3899/jrheum.150245
Nuclear Factor-κB–inducing Kinase Is Expressed in Synovial Endothelial Cells in Patients with Early Arthritis and Correlates with Markers of Inflammation: A Prospective Cohort Study
Karen I. Maijer, Ae Ri Noort, Maria J.H. de Hair, Christiaan van der Leij, Katinka P.M. van Zoest, Ivy Y. Choi, Daniëlle M. Gerlag, Mario Maas, Paul P. Tak, Sander W. Tas
The Journal of Rheumatology Jul 2015, jrheum.150245; DOI: 10.3899/jrheum.150245