Research ArticleArticle
Miscarriage and Stillbirth in Women with Rheumatoid Arthritis
Marianne Wallenius, Kjell Å. Salvesen, Anne K. Daltveit and Johan F. Skomsvoll
The Journal of Rheumatology July 2015, jrheum.141553; DOI: https://doi.org/10.3899/jrheum.141553
Marianne Wallenius
From the National Advisory Unit on Pregnancy and Rheumatic Diseases, Department of Rheumatology, and the National Center for Fetal Medicine, Department of Obstetrics and Gynecology, Trondheim University Hospital; Department of Neuroscience, and Department of Laboratory Medicine, Women’s and Child Health, Norwegian University of Science and Technology (NTNU), Trondheim; Department of Global Public Health and Primary Care, University of Bergen; Medical Birth Registry of Norway (MBRN), Division of Epidemiology, Norwegian Institute of Public Health, Bergen, Norway. Supported by the Liaison Committee between the Central Norway Regional Health Authority and the NTNU. M. Wallenius, MD, PhD, National Advisory Unit on Pregnancy and Rheumatic Diseases, Department of Rheumatology, Trondheim University Hospital, and the Department of Neuroscience, NTNU; K.Å. Salvesen, MD, PhD, National Center for Fetal Medicine, Department of Obstetrics and Gynecology, Trondheim University Hospital, and the Department of Laboratory Medicine, Women’s and Child Health, NTNU; A.K. Daltveit, PhD, Department of Global Public Health and Primary Care, University of Bergen, and the MBRN, Division of Epidemiology, Norwegian Institute of Public Health; J.F. Skomsvoll, MD, PhD, National Advisory Unit on Pregnancy and Rheumatic Diseases, Department of Rheumatology, Trondheim University Hospital. Address correspondence to Dr. M. Wallenius, National Advisory Unit on Pregnancy and Rheumatic Diseases, Department of Rheumatology, St. Olav’s Hospital (Trondheim University Hospital), Bevegelsessenteret, N-7006 Trondheim, Norway. E-mail: marianne.wallenius@ntnu.no. Accepted for publication May 26, 2015.
Kjell Å. Salvesen
From the National Advisory Unit on Pregnancy and Rheumatic Diseases, Department of Rheumatology, and the National Center for Fetal Medicine, Department of Obstetrics and Gynecology, Trondheim University Hospital; Department of Neuroscience, and Department of Laboratory Medicine, Women’s and Child Health, Norwegian University of Science and Technology (NTNU), Trondheim; Department of Global Public Health and Primary Care, University of Bergen; Medical Birth Registry of Norway (MBRN), Division of Epidemiology, Norwegian Institute of Public Health, Bergen, Norway. Supported by the Liaison Committee between the Central Norway Regional Health Authority and the NTNU. M. Wallenius, MD, PhD, National Advisory Unit on Pregnancy and Rheumatic Diseases, Department of Rheumatology, Trondheim University Hospital, and the Department of Neuroscience, NTNU; K.Å. Salvesen, MD, PhD, National Center for Fetal Medicine, Department of Obstetrics and Gynecology, Trondheim University Hospital, and the Department of Laboratory Medicine, Women’s and Child Health, NTNU; A.K. Daltveit, PhD, Department of Global Public Health and Primary Care, University of Bergen, and the MBRN, Division of Epidemiology, Norwegian Institute of Public Health; J.F. Skomsvoll, MD, PhD, National Advisory Unit on Pregnancy and Rheumatic Diseases, Department of Rheumatology, Trondheim University Hospital. Address correspondence to Dr. M. Wallenius, National Advisory Unit on Pregnancy and Rheumatic Diseases, Department of Rheumatology, St. Olav’s Hospital (Trondheim University Hospital), Bevegelsessenteret, N-7006 Trondheim, Norway. E-mail: marianne.wallenius@ntnu.no. Accepted for publication May 26, 2015.
Anne K. Daltveit
From the National Advisory Unit on Pregnancy and Rheumatic Diseases, Department of Rheumatology, and the National Center for Fetal Medicine, Department of Obstetrics and Gynecology, Trondheim University Hospital; Department of Neuroscience, and Department of Laboratory Medicine, Women’s and Child Health, Norwegian University of Science and Technology (NTNU), Trondheim; Department of Global Public Health and Primary Care, University of Bergen; Medical Birth Registry of Norway (MBRN), Division of Epidemiology, Norwegian Institute of Public Health, Bergen, Norway. Supported by the Liaison Committee between the Central Norway Regional Health Authority and the NTNU. M. Wallenius, MD, PhD, National Advisory Unit on Pregnancy and Rheumatic Diseases, Department of Rheumatology, Trondheim University Hospital, and the Department of Neuroscience, NTNU; K.Å. Salvesen, MD, PhD, National Center for Fetal Medicine, Department of Obstetrics and Gynecology, Trondheim University Hospital, and the Department of Laboratory Medicine, Women’s and Child Health, NTNU; A.K. Daltveit, PhD, Department of Global Public Health and Primary Care, University of Bergen, and the MBRN, Division of Epidemiology, Norwegian Institute of Public Health; J.F. Skomsvoll, MD, PhD, National Advisory Unit on Pregnancy and Rheumatic Diseases, Department of Rheumatology, Trondheim University Hospital. Address correspondence to Dr. M. Wallenius, National Advisory Unit on Pregnancy and Rheumatic Diseases, Department of Rheumatology, St. Olav’s Hospital (Trondheim University Hospital), Bevegelsessenteret, N-7006 Trondheim, Norway. E-mail: marianne.wallenius@ntnu.no. Accepted for publication May 26, 2015.
Johan F. Skomsvoll
From the National Advisory Unit on Pregnancy and Rheumatic Diseases, Department of Rheumatology, and the National Center for Fetal Medicine, Department of Obstetrics and Gynecology, Trondheim University Hospital; Department of Neuroscience, and Department of Laboratory Medicine, Women’s and Child Health, Norwegian University of Science and Technology (NTNU), Trondheim; Department of Global Public Health and Primary Care, University of Bergen; Medical Birth Registry of Norway (MBRN), Division of Epidemiology, Norwegian Institute of Public Health, Bergen, Norway. Supported by the Liaison Committee between the Central Norway Regional Health Authority and the NTNU. M. Wallenius, MD, PhD, National Advisory Unit on Pregnancy and Rheumatic Diseases, Department of Rheumatology, Trondheim University Hospital, and the Department of Neuroscience, NTNU; K.Å. Salvesen, MD, PhD, National Center for Fetal Medicine, Department of Obstetrics and Gynecology, Trondheim University Hospital, and the Department of Laboratory Medicine, Women’s and Child Health, NTNU; A.K. Daltveit, PhD, Department of Global Public Health and Primary Care, University of Bergen, and the MBRN, Division of Epidemiology, Norwegian Institute of Public Health; J.F. Skomsvoll, MD, PhD, National Advisory Unit on Pregnancy and Rheumatic Diseases, Department of Rheumatology, Trondheim University Hospital. Address correspondence to Dr. M. Wallenius, National Advisory Unit on Pregnancy and Rheumatic Diseases, Department of Rheumatology, St. Olav’s Hospital (Trondheim University Hospital), Bevegelsessenteret, N-7006 Trondheim, Norway. E-mail: marianne.wallenius@ntnu.no. Accepted for publication May 26, 2015.
Abstract
Objective To examine the risk of pregnancy loss in women with rheumatoid arthritis (RA).
Methods Cumulative numbers of early miscarriages (before gestational Week 12), late miscarriages (weeks 12–22), and stillbirths reported to the Medical Birth Registry of Norway in the period 1999–2009.
Results There were 1578 women with RA and 411,130 reference women included in the study. Relative risks of early and late miscarriage in women with RA versus references were 1.2 (95% CI 1.1–1.3) and 1.4 (95% CI 1.1–1.7), respectively. There was no difference in stillbirth.
Conclusion The risk of miscarriage was slightly higher among women with RA than in references.
In this issue
The Journal of Rheumatology
Vol. 51, Issue 4
1 Apr 2024
Miscarriage and Stillbirth in Women with Rheumatoid Arthritis
Marianne Wallenius, Kjell Å. Salvesen, Anne K. Daltveit, Johan F. Skomsvoll
The Journal of Rheumatology Jul 2015, jrheum.141553; DOI: 10.3899/jrheum.141553