Research ArticleArticle
Open Access
Longterm Safety of Tocilizumab: Results from 3 Years of Followup Postmarketing Surveillance of 5573 Patients with Rheumatoid Arthritis in Japan
Kazuhiko Yamamoto, Hajime Goto, Kenzo Hirao, Atsuo Nakajima, Hideki Origasa, Kunihiko Tanaka, Minako Tomobe and Kyoichi Totsuka
The Journal of Rheumatology June 2015, jrheum.141210; DOI: https://doi.org/10.3899/jrheum.141210
Kazuhiko Yamamoto
From the Department of Allergy and Rheumatology, Graduate School of Medicine, The University of Tokyo; Department of Respiratory Medicine, Fukujuji Hospital; Heart Rhythm Center, Tokyo Medical and Dental University; Department of Rheumatology, Tokyo Metropolitan Police Hospital, Tokyo; Division of Biostatistics and Clinical Epidemiology, University of Toyama School of Medicine, Toyama; Chugai Pharmaceutical Co. Ltd.; Department of Internal Medicine, Kitatama Hospital, Tokyo, Japan. Funded by Chugai Pharmaceutical Co. Ltd. Data were collected and analyzed by Chugai according to a prespecified protocol. Support for third-party writing assistance for this manuscript, furnished by Eric Deutsch, PhD, was provided by F. Hoffmann-La Roche Ltd. K. Yamamoto, MD, PhD, Department of Allergy and Rheumatology, Graduate School of Medicine, The University of Tokyo; H. Goto, MD, PhD, Department of Respiratory Medicine, Fukujuji Hospital; K. Hirao, MD, PhD, Heart Rhythm Center, Tokyo Medical and Dental University; A. Nakajima, MD, PhD, Department of Rheumatology, Tokyo Metropolitan Police Hospital; H. Origasa, PhD, Division of Biostatistics and Clinical Epidemiology, University of Toyama School of Medicine; K. Tanaka, MSc; M. Tomobe, BPharm, Chugai Pharmaceutical Co. Ltd.; K. Totsuka, MD, PhD, Department of Internal Medicine, Kitatama Hospital. Address correspondence to Dr. K. Yamamoto, MD, PhD, Department of Allergy and Rheumatology, Graduate School of Medicine, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-8655, Japan. E-mail: yamamoto-tky@umin.ac.jp. Full Release Article. For details see Reprints/Permissions at jrheum.org Accepted for publication March 31, 2015.
Hajime Goto
From the Department of Allergy and Rheumatology, Graduate School of Medicine, The University of Tokyo; Department of Respiratory Medicine, Fukujuji Hospital; Heart Rhythm Center, Tokyo Medical and Dental University; Department of Rheumatology, Tokyo Metropolitan Police Hospital, Tokyo; Division of Biostatistics and Clinical Epidemiology, University of Toyama School of Medicine, Toyama; Chugai Pharmaceutical Co. Ltd.; Department of Internal Medicine, Kitatama Hospital, Tokyo, Japan. Funded by Chugai Pharmaceutical Co. Ltd. Data were collected and analyzed by Chugai according to a prespecified protocol. Support for third-party writing assistance for this manuscript, furnished by Eric Deutsch, PhD, was provided by F. Hoffmann-La Roche Ltd. K. Yamamoto, MD, PhD, Department of Allergy and Rheumatology, Graduate School of Medicine, The University of Tokyo; H. Goto, MD, PhD, Department of Respiratory Medicine, Fukujuji Hospital; K. Hirao, MD, PhD, Heart Rhythm Center, Tokyo Medical and Dental University; A. Nakajima, MD, PhD, Department of Rheumatology, Tokyo Metropolitan Police Hospital; H. Origasa, PhD, Division of Biostatistics and Clinical Epidemiology, University of Toyama School of Medicine; K. Tanaka, MSc; M. Tomobe, BPharm, Chugai Pharmaceutical Co. Ltd.; K. Totsuka, MD, PhD, Department of Internal Medicine, Kitatama Hospital. Address correspondence to Dr. K. Yamamoto, MD, PhD, Department of Allergy and Rheumatology, Graduate School of Medicine, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-8655, Japan. E-mail: yamamoto-tky@umin.ac.jp. Full Release Article. For details see Reprints/Permissions at jrheum.org Accepted for publication March 31, 2015.
Kenzo Hirao
From the Department of Allergy and Rheumatology, Graduate School of Medicine, The University of Tokyo; Department of Respiratory Medicine, Fukujuji Hospital; Heart Rhythm Center, Tokyo Medical and Dental University; Department of Rheumatology, Tokyo Metropolitan Police Hospital, Tokyo; Division of Biostatistics and Clinical Epidemiology, University of Toyama School of Medicine, Toyama; Chugai Pharmaceutical Co. Ltd.; Department of Internal Medicine, Kitatama Hospital, Tokyo, Japan. Funded by Chugai Pharmaceutical Co. Ltd. Data were collected and analyzed by Chugai according to a prespecified protocol. Support for third-party writing assistance for this manuscript, furnished by Eric Deutsch, PhD, was provided by F. Hoffmann-La Roche Ltd. K. Yamamoto, MD, PhD, Department of Allergy and Rheumatology, Graduate School of Medicine, The University of Tokyo; H. Goto, MD, PhD, Department of Respiratory Medicine, Fukujuji Hospital; K. Hirao, MD, PhD, Heart Rhythm Center, Tokyo Medical and Dental University; A. Nakajima, MD, PhD, Department of Rheumatology, Tokyo Metropolitan Police Hospital; H. Origasa, PhD, Division of Biostatistics and Clinical Epidemiology, University of Toyama School of Medicine; K. Tanaka, MSc; M. Tomobe, BPharm, Chugai Pharmaceutical Co. Ltd.; K. Totsuka, MD, PhD, Department of Internal Medicine, Kitatama Hospital. Address correspondence to Dr. K. Yamamoto, MD, PhD, Department of Allergy and Rheumatology, Graduate School of Medicine, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-8655, Japan. E-mail: yamamoto-tky@umin.ac.jp. Full Release Article. For details see Reprints/Permissions at jrheum.org Accepted for publication March 31, 2015.
Atsuo Nakajima
From the Department of Allergy and Rheumatology, Graduate School of Medicine, The University of Tokyo; Department of Respiratory Medicine, Fukujuji Hospital; Heart Rhythm Center, Tokyo Medical and Dental University; Department of Rheumatology, Tokyo Metropolitan Police Hospital, Tokyo; Division of Biostatistics and Clinical Epidemiology, University of Toyama School of Medicine, Toyama; Chugai Pharmaceutical Co. Ltd.; Department of Internal Medicine, Kitatama Hospital, Tokyo, Japan. Funded by Chugai Pharmaceutical Co. Ltd. Data were collected and analyzed by Chugai according to a prespecified protocol. Support for third-party writing assistance for this manuscript, furnished by Eric Deutsch, PhD, was provided by F. Hoffmann-La Roche Ltd. K. Yamamoto, MD, PhD, Department of Allergy and Rheumatology, Graduate School of Medicine, The University of Tokyo; H. Goto, MD, PhD, Department of Respiratory Medicine, Fukujuji Hospital; K. Hirao, MD, PhD, Heart Rhythm Center, Tokyo Medical and Dental University; A. Nakajima, MD, PhD, Department of Rheumatology, Tokyo Metropolitan Police Hospital; H. Origasa, PhD, Division of Biostatistics and Clinical Epidemiology, University of Toyama School of Medicine; K. Tanaka, MSc; M. Tomobe, BPharm, Chugai Pharmaceutical Co. Ltd.; K. Totsuka, MD, PhD, Department of Internal Medicine, Kitatama Hospital. Address correspondence to Dr. K. Yamamoto, MD, PhD, Department of Allergy and Rheumatology, Graduate School of Medicine, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-8655, Japan. E-mail: yamamoto-tky@umin.ac.jp. Full Release Article. For details see Reprints/Permissions at jrheum.org Accepted for publication March 31, 2015.
Hideki Origasa
From the Department of Allergy and Rheumatology, Graduate School of Medicine, The University of Tokyo; Department of Respiratory Medicine, Fukujuji Hospital; Heart Rhythm Center, Tokyo Medical and Dental University; Department of Rheumatology, Tokyo Metropolitan Police Hospital, Tokyo; Division of Biostatistics and Clinical Epidemiology, University of Toyama School of Medicine, Toyama; Chugai Pharmaceutical Co. Ltd.; Department of Internal Medicine, Kitatama Hospital, Tokyo, Japan. Funded by Chugai Pharmaceutical Co. Ltd. Data were collected and analyzed by Chugai according to a prespecified protocol. Support for third-party writing assistance for this manuscript, furnished by Eric Deutsch, PhD, was provided by F. Hoffmann-La Roche Ltd. K. Yamamoto, MD, PhD, Department of Allergy and Rheumatology, Graduate School of Medicine, The University of Tokyo; H. Goto, MD, PhD, Department of Respiratory Medicine, Fukujuji Hospital; K. Hirao, MD, PhD, Heart Rhythm Center, Tokyo Medical and Dental University; A. Nakajima, MD, PhD, Department of Rheumatology, Tokyo Metropolitan Police Hospital; H. Origasa, PhD, Division of Biostatistics and Clinical Epidemiology, University of Toyama School of Medicine; K. Tanaka, MSc; M. Tomobe, BPharm, Chugai Pharmaceutical Co. Ltd.; K. Totsuka, MD, PhD, Department of Internal Medicine, Kitatama Hospital. Address correspondence to Dr. K. Yamamoto, MD, PhD, Department of Allergy and Rheumatology, Graduate School of Medicine, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-8655, Japan. E-mail: yamamoto-tky@umin.ac.jp. Full Release Article. For details see Reprints/Permissions at jrheum.org Accepted for publication March 31, 2015.
Kunihiko Tanaka
From the Department of Allergy and Rheumatology, Graduate School of Medicine, The University of Tokyo; Department of Respiratory Medicine, Fukujuji Hospital; Heart Rhythm Center, Tokyo Medical and Dental University; Department of Rheumatology, Tokyo Metropolitan Police Hospital, Tokyo; Division of Biostatistics and Clinical Epidemiology, University of Toyama School of Medicine, Toyama; Chugai Pharmaceutical Co. Ltd.; Department of Internal Medicine, Kitatama Hospital, Tokyo, Japan. Funded by Chugai Pharmaceutical Co. Ltd. Data were collected and analyzed by Chugai according to a prespecified protocol. Support for third-party writing assistance for this manuscript, furnished by Eric Deutsch, PhD, was provided by F. Hoffmann-La Roche Ltd. K. Yamamoto, MD, PhD, Department of Allergy and Rheumatology, Graduate School of Medicine, The University of Tokyo; H. Goto, MD, PhD, Department of Respiratory Medicine, Fukujuji Hospital; K. Hirao, MD, PhD, Heart Rhythm Center, Tokyo Medical and Dental University; A. Nakajima, MD, PhD, Department of Rheumatology, Tokyo Metropolitan Police Hospital; H. Origasa, PhD, Division of Biostatistics and Clinical Epidemiology, University of Toyama School of Medicine; K. Tanaka, MSc; M. Tomobe, BPharm, Chugai Pharmaceutical Co. Ltd.; K. Totsuka, MD, PhD, Department of Internal Medicine, Kitatama Hospital. Address correspondence to Dr. K. Yamamoto, MD, PhD, Department of Allergy and Rheumatology, Graduate School of Medicine, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-8655, Japan. E-mail: yamamoto-tky@umin.ac.jp. Full Release Article. For details see Reprints/Permissions at jrheum.org Accepted for publication March 31, 2015.
Minako Tomobe
From the Department of Allergy and Rheumatology, Graduate School of Medicine, The University of Tokyo; Department of Respiratory Medicine, Fukujuji Hospital; Heart Rhythm Center, Tokyo Medical and Dental University; Department of Rheumatology, Tokyo Metropolitan Police Hospital, Tokyo; Division of Biostatistics and Clinical Epidemiology, University of Toyama School of Medicine, Toyama; Chugai Pharmaceutical Co. Ltd.; Department of Internal Medicine, Kitatama Hospital, Tokyo, Japan. Funded by Chugai Pharmaceutical Co. Ltd. Data were collected and analyzed by Chugai according to a prespecified protocol. Support for third-party writing assistance for this manuscript, furnished by Eric Deutsch, PhD, was provided by F. Hoffmann-La Roche Ltd. K. Yamamoto, MD, PhD, Department of Allergy and Rheumatology, Graduate School of Medicine, The University of Tokyo; H. Goto, MD, PhD, Department of Respiratory Medicine, Fukujuji Hospital; K. Hirao, MD, PhD, Heart Rhythm Center, Tokyo Medical and Dental University; A. Nakajima, MD, PhD, Department of Rheumatology, Tokyo Metropolitan Police Hospital; H. Origasa, PhD, Division of Biostatistics and Clinical Epidemiology, University of Toyama School of Medicine; K. Tanaka, MSc; M. Tomobe, BPharm, Chugai Pharmaceutical Co. Ltd.; K. Totsuka, MD, PhD, Department of Internal Medicine, Kitatama Hospital. Address correspondence to Dr. K. Yamamoto, MD, PhD, Department of Allergy and Rheumatology, Graduate School of Medicine, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-8655, Japan. E-mail: yamamoto-tky@umin.ac.jp. Full Release Article. For details see Reprints/Permissions at jrheum.org Accepted for publication March 31, 2015.
Kyoichi Totsuka
From the Department of Allergy and Rheumatology, Graduate School of Medicine, The University of Tokyo; Department of Respiratory Medicine, Fukujuji Hospital; Heart Rhythm Center, Tokyo Medical and Dental University; Department of Rheumatology, Tokyo Metropolitan Police Hospital, Tokyo; Division of Biostatistics and Clinical Epidemiology, University of Toyama School of Medicine, Toyama; Chugai Pharmaceutical Co. Ltd.; Department of Internal Medicine, Kitatama Hospital, Tokyo, Japan. Funded by Chugai Pharmaceutical Co. Ltd. Data were collected and analyzed by Chugai according to a prespecified protocol. Support for third-party writing assistance for this manuscript, furnished by Eric Deutsch, PhD, was provided by F. Hoffmann-La Roche Ltd. K. Yamamoto, MD, PhD, Department of Allergy and Rheumatology, Graduate School of Medicine, The University of Tokyo; H. Goto, MD, PhD, Department of Respiratory Medicine, Fukujuji Hospital; K. Hirao, MD, PhD, Heart Rhythm Center, Tokyo Medical and Dental University; A. Nakajima, MD, PhD, Department of Rheumatology, Tokyo Metropolitan Police Hospital; H. Origasa, PhD, Division of Biostatistics and Clinical Epidemiology, University of Toyama School of Medicine; K. Tanaka, MSc; M. Tomobe, BPharm, Chugai Pharmaceutical Co. Ltd.; K. Totsuka, MD, PhD, Department of Internal Medicine, Kitatama Hospital. Address correspondence to Dr. K. Yamamoto, MD, PhD, Department of Allergy and Rheumatology, Graduate School of Medicine, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-8655, Japan. E-mail: yamamoto-tky@umin.ac.jp. Full Release Article. For details see Reprints/Permissions at jrheum.org Accepted for publication March 31, 2015.
In this issue
The Journal of Rheumatology
Vol. 51, Issue 4
1 Apr 2024
Longterm Safety of Tocilizumab: Results from 3 Years of Followup Postmarketing Surveillance of 5573 Patients with Rheumatoid Arthritis in Japan
Kazuhiko Yamamoto, Hajime Goto, Kenzo Hirao, Atsuo Nakajima, Hideki Origasa, Kunihiko Tanaka, Minako Tomobe, Kyoichi Totsuka
The Journal of Rheumatology Jun 2015, jrheum.141210; DOI: 10.3899/jrheum.141210
Longterm Safety of Tocilizumab: Results from 3 Years of Followup Postmarketing Surveillance of 5573 Patients with Rheumatoid Arthritis in Japan
Kazuhiko Yamamoto, Hajime Goto, Kenzo Hirao, Atsuo Nakajima, Hideki Origasa, Kunihiko Tanaka, Minako Tomobe, Kyoichi Totsuka
The Journal of Rheumatology Jun 2015, jrheum.141210; DOI: 10.3899/jrheum.141210