Research ArticleArticle
Do Genetic Susceptibility Variants Associate with Disease Severity in Early Active Rheumatoid Arthritis?
Ian C. Scott, Frühling Rijsdijk, Jemma Walker, Jelmar Quist, Sarah L. Spain, Rachael Tan, Sophia Steer, Yukinori Okada, Soumya Raychaudhuri, Andrew P. Cope and Cathryn M. Lewis
The Journal of Rheumatology May 2015, jrheum.141211; DOI: https://doi.org/10.3899/jrheum.141211
Ian C. Scott
From the Department of Medical and Molecular Genetics, and Academic Department of Rheumatology, Centre for Molecular and Cellular Biology of Inflammation, and Social, Genetic and Developmental Psychiatry (SGDP) Centre, Institute of Psychiatry, and Department of Rheumatology, King’s College London, and Guy’s Hospital, London, UK; Department of Human Genetics and Disease Diversity, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University, Tokyo; Laboratory for Statistical Analysis, RIKEN Center for Integrative Medical Sciences, Yokohama, Japan; Division of Genetics, Brigham and Women’s Hospital, Harvard Medical School, Boston, Massachusetts, USA. Supported by Arthritis Research UK (Grant Reference Number 19739 to ICS) and the National Institute for Health Research (NIHR; Clinical Lectureship to ICS). We also acknowledge support from the NIHR Biomedical Research Centre at Guy’s and St. Thomas’ National Health Service Foundation Trust in partnership with King’s College London. I.C. Scott, PhD, Clinical Research Fellow, Department of Medical and Molecular Genetics, and Academic Department of Rheumatology, Centre for Molecular and Cellular Biology of Inflammation, King’s College London, and Guy’s Hospital; F. Rijsdijk, PhD, Reader, SGDP Centre, Institute of Psychiatry, King’s College London; J. Walker, PhD, Statistical Geneticist; J. Quist, PhD, MSc, Student; S.L. Spain, PhD, Research Associate, Department of Medical and Molecular Genetics, King’s College London, and Guy’s Hospital; R. Tan, MRes, Core Medical Trainee, Academic Department of Rheumatology, Centre for Molecular and Cellular Biology of Inflammation, King’s College London; S. Steer, PhD, Consultant Rheumatologist, Department of Rheumatology, King’s College Hospital; Y. Okada, PhD, Tenure Track Junior Associate Professor, Department of Human Genetics and Disease Diversity, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University, and Laboratory for Statistical Analysis, RIKEN Center for Integrative Medical Sciences; S. Raychaudhuri, PhD, Professor, Division of Genetics, Brigham and Women’s Hospital, Harvard Medical School; A.P. Cope, PhD, Professor, Academic Department of Rheumatology, Centre for Molecular and Cellular Biology of Inflammation, King’s College London; C.M. Lewis, PhD, Professor, Department of Medical and Molecular Genetics, and SGDP Centre, Institute of Psychiatry, King’s College London, and Guy’s Hospital. Address correspondence to Dr. I.C. Scott, Department of Medical and Molecular Genetics, King’s College London, 8th Floor Tower Wing, Guy’s Hospital, Great Maze Pond, London, SE1 9RT, UK. E-mail: ian.scott@kcl.ac.uk. Accepted for publication March 18, 2015.
Frühling Rijsdijk
From the Department of Medical and Molecular Genetics, and Academic Department of Rheumatology, Centre for Molecular and Cellular Biology of Inflammation, and Social, Genetic and Developmental Psychiatry (SGDP) Centre, Institute of Psychiatry, and Department of Rheumatology, King’s College London, and Guy’s Hospital, London, UK; Department of Human Genetics and Disease Diversity, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University, Tokyo; Laboratory for Statistical Analysis, RIKEN Center for Integrative Medical Sciences, Yokohama, Japan; Division of Genetics, Brigham and Women’s Hospital, Harvard Medical School, Boston, Massachusetts, USA. Supported by Arthritis Research UK (Grant Reference Number 19739 to ICS) and the National Institute for Health Research (NIHR; Clinical Lectureship to ICS). We also acknowledge support from the NIHR Biomedical Research Centre at Guy’s and St. Thomas’ National Health Service Foundation Trust in partnership with King’s College London. I.C. Scott, PhD, Clinical Research Fellow, Department of Medical and Molecular Genetics, and Academic Department of Rheumatology, Centre for Molecular and Cellular Biology of Inflammation, King’s College London, and Guy’s Hospital; F. Rijsdijk, PhD, Reader, SGDP Centre, Institute of Psychiatry, King’s College London; J. Walker, PhD, Statistical Geneticist; J. Quist, PhD, MSc, Student; S.L. Spain, PhD, Research Associate, Department of Medical and Molecular Genetics, King’s College London, and Guy’s Hospital; R. Tan, MRes, Core Medical Trainee, Academic Department of Rheumatology, Centre for Molecular and Cellular Biology of Inflammation, King’s College London; S. Steer, PhD, Consultant Rheumatologist, Department of Rheumatology, King’s College Hospital; Y. Okada, PhD, Tenure Track Junior Associate Professor, Department of Human Genetics and Disease Diversity, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University, and Laboratory for Statistical Analysis, RIKEN Center for Integrative Medical Sciences; S. Raychaudhuri, PhD, Professor, Division of Genetics, Brigham and Women’s Hospital, Harvard Medical School; A.P. Cope, PhD, Professor, Academic Department of Rheumatology, Centre for Molecular and Cellular Biology of Inflammation, King’s College London; C.M. Lewis, PhD, Professor, Department of Medical and Molecular Genetics, and SGDP Centre, Institute of Psychiatry, King’s College London, and Guy’s Hospital. Address correspondence to Dr. I.C. Scott, Department of Medical and Molecular Genetics, King’s College London, 8th Floor Tower Wing, Guy’s Hospital, Great Maze Pond, London, SE1 9RT, UK. E-mail: ian.scott@kcl.ac.uk. Accepted for publication March 18, 2015.
Jemma Walker
From the Department of Medical and Molecular Genetics, and Academic Department of Rheumatology, Centre for Molecular and Cellular Biology of Inflammation, and Social, Genetic and Developmental Psychiatry (SGDP) Centre, Institute of Psychiatry, and Department of Rheumatology, King’s College London, and Guy’s Hospital, London, UK; Department of Human Genetics and Disease Diversity, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University, Tokyo; Laboratory for Statistical Analysis, RIKEN Center for Integrative Medical Sciences, Yokohama, Japan; Division of Genetics, Brigham and Women’s Hospital, Harvard Medical School, Boston, Massachusetts, USA. Supported by Arthritis Research UK (Grant Reference Number 19739 to ICS) and the National Institute for Health Research (NIHR; Clinical Lectureship to ICS). We also acknowledge support from the NIHR Biomedical Research Centre at Guy’s and St. Thomas’ National Health Service Foundation Trust in partnership with King’s College London. I.C. Scott, PhD, Clinical Research Fellow, Department of Medical and Molecular Genetics, and Academic Department of Rheumatology, Centre for Molecular and Cellular Biology of Inflammation, King’s College London, and Guy’s Hospital; F. Rijsdijk, PhD, Reader, SGDP Centre, Institute of Psychiatry, King’s College London; J. Walker, PhD, Statistical Geneticist; J. Quist, PhD, MSc, Student; S.L. Spain, PhD, Research Associate, Department of Medical and Molecular Genetics, King’s College London, and Guy’s Hospital; R. Tan, MRes, Core Medical Trainee, Academic Department of Rheumatology, Centre for Molecular and Cellular Biology of Inflammation, King’s College London; S. Steer, PhD, Consultant Rheumatologist, Department of Rheumatology, King’s College Hospital; Y. Okada, PhD, Tenure Track Junior Associate Professor, Department of Human Genetics and Disease Diversity, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University, and Laboratory for Statistical Analysis, RIKEN Center for Integrative Medical Sciences; S. Raychaudhuri, PhD, Professor, Division of Genetics, Brigham and Women’s Hospital, Harvard Medical School; A.P. Cope, PhD, Professor, Academic Department of Rheumatology, Centre for Molecular and Cellular Biology of Inflammation, King’s College London; C.M. Lewis, PhD, Professor, Department of Medical and Molecular Genetics, and SGDP Centre, Institute of Psychiatry, King’s College London, and Guy’s Hospital. Address correspondence to Dr. I.C. Scott, Department of Medical and Molecular Genetics, King’s College London, 8th Floor Tower Wing, Guy’s Hospital, Great Maze Pond, London, SE1 9RT, UK. E-mail: ian.scott@kcl.ac.uk. Accepted for publication March 18, 2015.
Jelmar Quist
From the Department of Medical and Molecular Genetics, and Academic Department of Rheumatology, Centre for Molecular and Cellular Biology of Inflammation, and Social, Genetic and Developmental Psychiatry (SGDP) Centre, Institute of Psychiatry, and Department of Rheumatology, King’s College London, and Guy’s Hospital, London, UK; Department of Human Genetics and Disease Diversity, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University, Tokyo; Laboratory for Statistical Analysis, RIKEN Center for Integrative Medical Sciences, Yokohama, Japan; Division of Genetics, Brigham and Women’s Hospital, Harvard Medical School, Boston, Massachusetts, USA. Supported by Arthritis Research UK (Grant Reference Number 19739 to ICS) and the National Institute for Health Research (NIHR; Clinical Lectureship to ICS). We also acknowledge support from the NIHR Biomedical Research Centre at Guy’s and St. Thomas’ National Health Service Foundation Trust in partnership with King’s College London. I.C. Scott, PhD, Clinical Research Fellow, Department of Medical and Molecular Genetics, and Academic Department of Rheumatology, Centre for Molecular and Cellular Biology of Inflammation, King’s College London, and Guy’s Hospital; F. Rijsdijk, PhD, Reader, SGDP Centre, Institute of Psychiatry, King’s College London; J. Walker, PhD, Statistical Geneticist; J. Quist, PhD, MSc, Student; S.L. Spain, PhD, Research Associate, Department of Medical and Molecular Genetics, King’s College London, and Guy’s Hospital; R. Tan, MRes, Core Medical Trainee, Academic Department of Rheumatology, Centre for Molecular and Cellular Biology of Inflammation, King’s College London; S. Steer, PhD, Consultant Rheumatologist, Department of Rheumatology, King’s College Hospital; Y. Okada, PhD, Tenure Track Junior Associate Professor, Department of Human Genetics and Disease Diversity, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University, and Laboratory for Statistical Analysis, RIKEN Center for Integrative Medical Sciences; S. Raychaudhuri, PhD, Professor, Division of Genetics, Brigham and Women’s Hospital, Harvard Medical School; A.P. Cope, PhD, Professor, Academic Department of Rheumatology, Centre for Molecular and Cellular Biology of Inflammation, King’s College London; C.M. Lewis, PhD, Professor, Department of Medical and Molecular Genetics, and SGDP Centre, Institute of Psychiatry, King’s College London, and Guy’s Hospital. Address correspondence to Dr. I.C. Scott, Department of Medical and Molecular Genetics, King’s College London, 8th Floor Tower Wing, Guy’s Hospital, Great Maze Pond, London, SE1 9RT, UK. E-mail: ian.scott@kcl.ac.uk. Accepted for publication March 18, 2015.
Sarah L. Spain
From the Department of Medical and Molecular Genetics, and Academic Department of Rheumatology, Centre for Molecular and Cellular Biology of Inflammation, and Social, Genetic and Developmental Psychiatry (SGDP) Centre, Institute of Psychiatry, and Department of Rheumatology, King’s College London, and Guy’s Hospital, London, UK; Department of Human Genetics and Disease Diversity, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University, Tokyo; Laboratory for Statistical Analysis, RIKEN Center for Integrative Medical Sciences, Yokohama, Japan; Division of Genetics, Brigham and Women’s Hospital, Harvard Medical School, Boston, Massachusetts, USA. Supported by Arthritis Research UK (Grant Reference Number 19739 to ICS) and the National Institute for Health Research (NIHR; Clinical Lectureship to ICS). We also acknowledge support from the NIHR Biomedical Research Centre at Guy’s and St. Thomas’ National Health Service Foundation Trust in partnership with King’s College London. I.C. Scott, PhD, Clinical Research Fellow, Department of Medical and Molecular Genetics, and Academic Department of Rheumatology, Centre for Molecular and Cellular Biology of Inflammation, King’s College London, and Guy’s Hospital; F. Rijsdijk, PhD, Reader, SGDP Centre, Institute of Psychiatry, King’s College London; J. Walker, PhD, Statistical Geneticist; J. Quist, PhD, MSc, Student; S.L. Spain, PhD, Research Associate, Department of Medical and Molecular Genetics, King’s College London, and Guy’s Hospital; R. Tan, MRes, Core Medical Trainee, Academic Department of Rheumatology, Centre for Molecular and Cellular Biology of Inflammation, King’s College London; S. Steer, PhD, Consultant Rheumatologist, Department of Rheumatology, King’s College Hospital; Y. Okada, PhD, Tenure Track Junior Associate Professor, Department of Human Genetics and Disease Diversity, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University, and Laboratory for Statistical Analysis, RIKEN Center for Integrative Medical Sciences; S. Raychaudhuri, PhD, Professor, Division of Genetics, Brigham and Women’s Hospital, Harvard Medical School; A.P. Cope, PhD, Professor, Academic Department of Rheumatology, Centre for Molecular and Cellular Biology of Inflammation, King’s College London; C.M. Lewis, PhD, Professor, Department of Medical and Molecular Genetics, and SGDP Centre, Institute of Psychiatry, King’s College London, and Guy’s Hospital. Address correspondence to Dr. I.C. Scott, Department of Medical and Molecular Genetics, King’s College London, 8th Floor Tower Wing, Guy’s Hospital, Great Maze Pond, London, SE1 9RT, UK. E-mail: ian.scott@kcl.ac.uk. Accepted for publication March 18, 2015.
Rachael Tan
From the Department of Medical and Molecular Genetics, and Academic Department of Rheumatology, Centre for Molecular and Cellular Biology of Inflammation, and Social, Genetic and Developmental Psychiatry (SGDP) Centre, Institute of Psychiatry, and Department of Rheumatology, King’s College London, and Guy’s Hospital, London, UK; Department of Human Genetics and Disease Diversity, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University, Tokyo; Laboratory for Statistical Analysis, RIKEN Center for Integrative Medical Sciences, Yokohama, Japan; Division of Genetics, Brigham and Women’s Hospital, Harvard Medical School, Boston, Massachusetts, USA. Supported by Arthritis Research UK (Grant Reference Number 19739 to ICS) and the National Institute for Health Research (NIHR; Clinical Lectureship to ICS). We also acknowledge support from the NIHR Biomedical Research Centre at Guy’s and St. Thomas’ National Health Service Foundation Trust in partnership with King’s College London. I.C. Scott, PhD, Clinical Research Fellow, Department of Medical and Molecular Genetics, and Academic Department of Rheumatology, Centre for Molecular and Cellular Biology of Inflammation, King’s College London, and Guy’s Hospital; F. Rijsdijk, PhD, Reader, SGDP Centre, Institute of Psychiatry, King’s College London; J. Walker, PhD, Statistical Geneticist; J. Quist, PhD, MSc, Student; S.L. Spain, PhD, Research Associate, Department of Medical and Molecular Genetics, King’s College London, and Guy’s Hospital; R. Tan, MRes, Core Medical Trainee, Academic Department of Rheumatology, Centre for Molecular and Cellular Biology of Inflammation, King’s College London; S. Steer, PhD, Consultant Rheumatologist, Department of Rheumatology, King’s College Hospital; Y. Okada, PhD, Tenure Track Junior Associate Professor, Department of Human Genetics and Disease Diversity, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University, and Laboratory for Statistical Analysis, RIKEN Center for Integrative Medical Sciences; S. Raychaudhuri, PhD, Professor, Division of Genetics, Brigham and Women’s Hospital, Harvard Medical School; A.P. Cope, PhD, Professor, Academic Department of Rheumatology, Centre for Molecular and Cellular Biology of Inflammation, King’s College London; C.M. Lewis, PhD, Professor, Department of Medical and Molecular Genetics, and SGDP Centre, Institute of Psychiatry, King’s College London, and Guy’s Hospital. Address correspondence to Dr. I.C. Scott, Department of Medical and Molecular Genetics, King’s College London, 8th Floor Tower Wing, Guy’s Hospital, Great Maze Pond, London, SE1 9RT, UK. E-mail: ian.scott@kcl.ac.uk. Accepted for publication March 18, 2015.
Sophia Steer
From the Department of Medical and Molecular Genetics, and Academic Department of Rheumatology, Centre for Molecular and Cellular Biology of Inflammation, and Social, Genetic and Developmental Psychiatry (SGDP) Centre, Institute of Psychiatry, and Department of Rheumatology, King’s College London, and Guy’s Hospital, London, UK; Department of Human Genetics and Disease Diversity, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University, Tokyo; Laboratory for Statistical Analysis, RIKEN Center for Integrative Medical Sciences, Yokohama, Japan; Division of Genetics, Brigham and Women’s Hospital, Harvard Medical School, Boston, Massachusetts, USA. Supported by Arthritis Research UK (Grant Reference Number 19739 to ICS) and the National Institute for Health Research (NIHR; Clinical Lectureship to ICS). We also acknowledge support from the NIHR Biomedical Research Centre at Guy’s and St. Thomas’ National Health Service Foundation Trust in partnership with King’s College London. I.C. Scott, PhD, Clinical Research Fellow, Department of Medical and Molecular Genetics, and Academic Department of Rheumatology, Centre for Molecular and Cellular Biology of Inflammation, King’s College London, and Guy’s Hospital; F. Rijsdijk, PhD, Reader, SGDP Centre, Institute of Psychiatry, King’s College London; J. Walker, PhD, Statistical Geneticist; J. Quist, PhD, MSc, Student; S.L. Spain, PhD, Research Associate, Department of Medical and Molecular Genetics, King’s College London, and Guy’s Hospital; R. Tan, MRes, Core Medical Trainee, Academic Department of Rheumatology, Centre for Molecular and Cellular Biology of Inflammation, King’s College London; S. Steer, PhD, Consultant Rheumatologist, Department of Rheumatology, King’s College Hospital; Y. Okada, PhD, Tenure Track Junior Associate Professor, Department of Human Genetics and Disease Diversity, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University, and Laboratory for Statistical Analysis, RIKEN Center for Integrative Medical Sciences; S. Raychaudhuri, PhD, Professor, Division of Genetics, Brigham and Women’s Hospital, Harvard Medical School; A.P. Cope, PhD, Professor, Academic Department of Rheumatology, Centre for Molecular and Cellular Biology of Inflammation, King’s College London; C.M. Lewis, PhD, Professor, Department of Medical and Molecular Genetics, and SGDP Centre, Institute of Psychiatry, King’s College London, and Guy’s Hospital. Address correspondence to Dr. I.C. Scott, Department of Medical and Molecular Genetics, King’s College London, 8th Floor Tower Wing, Guy’s Hospital, Great Maze Pond, London, SE1 9RT, UK. E-mail: ian.scott@kcl.ac.uk. Accepted for publication March 18, 2015.
Yukinori Okada
From the Department of Medical and Molecular Genetics, and Academic Department of Rheumatology, Centre for Molecular and Cellular Biology of Inflammation, and Social, Genetic and Developmental Psychiatry (SGDP) Centre, Institute of Psychiatry, and Department of Rheumatology, King’s College London, and Guy’s Hospital, London, UK; Department of Human Genetics and Disease Diversity, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University, Tokyo; Laboratory for Statistical Analysis, RIKEN Center for Integrative Medical Sciences, Yokohama, Japan; Division of Genetics, Brigham and Women’s Hospital, Harvard Medical School, Boston, Massachusetts, USA. Supported by Arthritis Research UK (Grant Reference Number 19739 to ICS) and the National Institute for Health Research (NIHR; Clinical Lectureship to ICS). We also acknowledge support from the NIHR Biomedical Research Centre at Guy’s and St. Thomas’ National Health Service Foundation Trust in partnership with King’s College London. I.C. Scott, PhD, Clinical Research Fellow, Department of Medical and Molecular Genetics, and Academic Department of Rheumatology, Centre for Molecular and Cellular Biology of Inflammation, King’s College London, and Guy’s Hospital; F. Rijsdijk, PhD, Reader, SGDP Centre, Institute of Psychiatry, King’s College London; J. Walker, PhD, Statistical Geneticist; J. Quist, PhD, MSc, Student; S.L. Spain, PhD, Research Associate, Department of Medical and Molecular Genetics, King’s College London, and Guy’s Hospital; R. Tan, MRes, Core Medical Trainee, Academic Department of Rheumatology, Centre for Molecular and Cellular Biology of Inflammation, King’s College London; S. Steer, PhD, Consultant Rheumatologist, Department of Rheumatology, King’s College Hospital; Y. Okada, PhD, Tenure Track Junior Associate Professor, Department of Human Genetics and Disease Diversity, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University, and Laboratory for Statistical Analysis, RIKEN Center for Integrative Medical Sciences; S. Raychaudhuri, PhD, Professor, Division of Genetics, Brigham and Women’s Hospital, Harvard Medical School; A.P. Cope, PhD, Professor, Academic Department of Rheumatology, Centre for Molecular and Cellular Biology of Inflammation, King’s College London; C.M. Lewis, PhD, Professor, Department of Medical and Molecular Genetics, and SGDP Centre, Institute of Psychiatry, King’s College London, and Guy’s Hospital. Address correspondence to Dr. I.C. Scott, Department of Medical and Molecular Genetics, King’s College London, 8th Floor Tower Wing, Guy’s Hospital, Great Maze Pond, London, SE1 9RT, UK. E-mail: ian.scott@kcl.ac.uk. Accepted for publication March 18, 2015.
Soumya Raychaudhuri
From the Department of Medical and Molecular Genetics, and Academic Department of Rheumatology, Centre for Molecular and Cellular Biology of Inflammation, and Social, Genetic and Developmental Psychiatry (SGDP) Centre, Institute of Psychiatry, and Department of Rheumatology, King’s College London, and Guy’s Hospital, London, UK; Department of Human Genetics and Disease Diversity, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University, Tokyo; Laboratory for Statistical Analysis, RIKEN Center for Integrative Medical Sciences, Yokohama, Japan; Division of Genetics, Brigham and Women’s Hospital, Harvard Medical School, Boston, Massachusetts, USA. Supported by Arthritis Research UK (Grant Reference Number 19739 to ICS) and the National Institute for Health Research (NIHR; Clinical Lectureship to ICS). We also acknowledge support from the NIHR Biomedical Research Centre at Guy’s and St. Thomas’ National Health Service Foundation Trust in partnership with King’s College London. I.C. Scott, PhD, Clinical Research Fellow, Department of Medical and Molecular Genetics, and Academic Department of Rheumatology, Centre for Molecular and Cellular Biology of Inflammation, King’s College London, and Guy’s Hospital; F. Rijsdijk, PhD, Reader, SGDP Centre, Institute of Psychiatry, King’s College London; J. Walker, PhD, Statistical Geneticist; J. Quist, PhD, MSc, Student; S.L. Spain, PhD, Research Associate, Department of Medical and Molecular Genetics, King’s College London, and Guy’s Hospital; R. Tan, MRes, Core Medical Trainee, Academic Department of Rheumatology, Centre for Molecular and Cellular Biology of Inflammation, King’s College London; S. Steer, PhD, Consultant Rheumatologist, Department of Rheumatology, King’s College Hospital; Y. Okada, PhD, Tenure Track Junior Associate Professor, Department of Human Genetics and Disease Diversity, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University, and Laboratory for Statistical Analysis, RIKEN Center for Integrative Medical Sciences; S. Raychaudhuri, PhD, Professor, Division of Genetics, Brigham and Women’s Hospital, Harvard Medical School; A.P. Cope, PhD, Professor, Academic Department of Rheumatology, Centre for Molecular and Cellular Biology of Inflammation, King’s College London; C.M. Lewis, PhD, Professor, Department of Medical and Molecular Genetics, and SGDP Centre, Institute of Psychiatry, King’s College London, and Guy’s Hospital. Address correspondence to Dr. I.C. Scott, Department of Medical and Molecular Genetics, King’s College London, 8th Floor Tower Wing, Guy’s Hospital, Great Maze Pond, London, SE1 9RT, UK. E-mail: ian.scott@kcl.ac.uk. Accepted for publication March 18, 2015.
Andrew P. Cope
From the Department of Medical and Molecular Genetics, and Academic Department of Rheumatology, Centre for Molecular and Cellular Biology of Inflammation, and Social, Genetic and Developmental Psychiatry (SGDP) Centre, Institute of Psychiatry, and Department of Rheumatology, King’s College London, and Guy’s Hospital, London, UK; Department of Human Genetics and Disease Diversity, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University, Tokyo; Laboratory for Statistical Analysis, RIKEN Center for Integrative Medical Sciences, Yokohama, Japan; Division of Genetics, Brigham and Women’s Hospital, Harvard Medical School, Boston, Massachusetts, USA. Supported by Arthritis Research UK (Grant Reference Number 19739 to ICS) and the National Institute for Health Research (NIHR; Clinical Lectureship to ICS). We also acknowledge support from the NIHR Biomedical Research Centre at Guy’s and St. Thomas’ National Health Service Foundation Trust in partnership with King’s College London. I.C. Scott, PhD, Clinical Research Fellow, Department of Medical and Molecular Genetics, and Academic Department of Rheumatology, Centre for Molecular and Cellular Biology of Inflammation, King’s College London, and Guy’s Hospital; F. Rijsdijk, PhD, Reader, SGDP Centre, Institute of Psychiatry, King’s College London; J. Walker, PhD, Statistical Geneticist; J. Quist, PhD, MSc, Student; S.L. Spain, PhD, Research Associate, Department of Medical and Molecular Genetics, King’s College London, and Guy’s Hospital; R. Tan, MRes, Core Medical Trainee, Academic Department of Rheumatology, Centre for Molecular and Cellular Biology of Inflammation, King’s College London; S. Steer, PhD, Consultant Rheumatologist, Department of Rheumatology, King’s College Hospital; Y. Okada, PhD, Tenure Track Junior Associate Professor, Department of Human Genetics and Disease Diversity, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University, and Laboratory for Statistical Analysis, RIKEN Center for Integrative Medical Sciences; S. Raychaudhuri, PhD, Professor, Division of Genetics, Brigham and Women’s Hospital, Harvard Medical School; A.P. Cope, PhD, Professor, Academic Department of Rheumatology, Centre for Molecular and Cellular Biology of Inflammation, King’s College London; C.M. Lewis, PhD, Professor, Department of Medical and Molecular Genetics, and SGDP Centre, Institute of Psychiatry, King’s College London, and Guy’s Hospital. Address correspondence to Dr. I.C. Scott, Department of Medical and Molecular Genetics, King’s College London, 8th Floor Tower Wing, Guy’s Hospital, Great Maze Pond, London, SE1 9RT, UK. E-mail: ian.scott@kcl.ac.uk. Accepted for publication March 18, 2015.
Cathryn M. Lewis
From the Department of Medical and Molecular Genetics, and Academic Department of Rheumatology, Centre for Molecular and Cellular Biology of Inflammation, and Social, Genetic and Developmental Psychiatry (SGDP) Centre, Institute of Psychiatry, and Department of Rheumatology, King’s College London, and Guy’s Hospital, London, UK; Department of Human Genetics and Disease Diversity, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University, Tokyo; Laboratory for Statistical Analysis, RIKEN Center for Integrative Medical Sciences, Yokohama, Japan; Division of Genetics, Brigham and Women’s Hospital, Harvard Medical School, Boston, Massachusetts, USA. Supported by Arthritis Research UK (Grant Reference Number 19739 to ICS) and the National Institute for Health Research (NIHR; Clinical Lectureship to ICS). We also acknowledge support from the NIHR Biomedical Research Centre at Guy’s and St. Thomas’ National Health Service Foundation Trust in partnership with King’s College London. I.C. Scott, PhD, Clinical Research Fellow, Department of Medical and Molecular Genetics, and Academic Department of Rheumatology, Centre for Molecular and Cellular Biology of Inflammation, King’s College London, and Guy’s Hospital; F. Rijsdijk, PhD, Reader, SGDP Centre, Institute of Psychiatry, King’s College London; J. Walker, PhD, Statistical Geneticist; J. Quist, PhD, MSc, Student; S.L. Spain, PhD, Research Associate, Department of Medical and Molecular Genetics, King’s College London, and Guy’s Hospital; R. Tan, MRes, Core Medical Trainee, Academic Department of Rheumatology, Centre for Molecular and Cellular Biology of Inflammation, King’s College London; S. Steer, PhD, Consultant Rheumatologist, Department of Rheumatology, King’s College Hospital; Y. Okada, PhD, Tenure Track Junior Associate Professor, Department of Human Genetics and Disease Diversity, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University, and Laboratory for Statistical Analysis, RIKEN Center for Integrative Medical Sciences; S. Raychaudhuri, PhD, Professor, Division of Genetics, Brigham and Women’s Hospital, Harvard Medical School; A.P. Cope, PhD, Professor, Academic Department of Rheumatology, Centre for Molecular and Cellular Biology of Inflammation, King’s College London; C.M. Lewis, PhD, Professor, Department of Medical and Molecular Genetics, and SGDP Centre, Institute of Psychiatry, King’s College London, and Guy’s Hospital. Address correspondence to Dr. I.C. Scott, Department of Medical and Molecular Genetics, King’s College London, 8th Floor Tower Wing, Guy’s Hospital, Great Maze Pond, London, SE1 9RT, UK. E-mail: ian.scott@kcl.ac.uk. Accepted for publication March 18, 2015.
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In this issue
The Journal of Rheumatology
Vol. 51, Issue 4
1 Apr 2024
Do Genetic Susceptibility Variants Associate with Disease Severity in Early Active Rheumatoid Arthritis?
Ian C. Scott, Frühling Rijsdijk, Jemma Walker, Jelmar Quist, Sarah L. Spain, Rachael Tan, Sophia Steer, Yukinori Okada, Soumya Raychaudhuri, Andrew P. Cope, Cathryn M. Lewis
The Journal of Rheumatology May 2015, jrheum.141211; DOI: 10.3899/jrheum.141211
Do Genetic Susceptibility Variants Associate with Disease Severity in Early Active Rheumatoid Arthritis?
Ian C. Scott, Frühling Rijsdijk, Jemma Walker, Jelmar Quist, Sarah L. Spain, Rachael Tan, Sophia Steer, Yukinori Okada, Soumya Raychaudhuri, Andrew P. Cope, Cathryn M. Lewis
The Journal of Rheumatology May 2015, jrheum.141211; DOI: 10.3899/jrheum.141211