Research ArticleArticle
Longterm Safety and Efficacy of Subcutaneous Tocilizumab Monotherapy: Results from the 2-year Open-label Extension of the MUSASHI Study
Atsushi Ogata, Koichi Amano, Hiroaki Dobashi, Masayuki Inoo, Tomonori Ishii, Tsuyoshi Kasama, Shinichi Kawai, Atsushi Kawakami, Tatsuya Koike, Hisaaki Miyahara, Toshiaki Miyamoto, Yasuhiko Munakata, Akira Murasawa, Norihiro Nishimoto, Noriyoshi Ogawa, Tomohiro Ojima, Hajime Sano, Kenrin Shi, Eisuke Shono, Eiichi Suematsu, Hiroki Takahashi, Yoshiya Tanaka, Hiroshi Tsukamoto and Akira Nomura
The Journal of Rheumatology April 2015, jrheum.140665; DOI: https://doi.org/10.3899/jrheum.140665
Atsushi Ogata
From the Department of Respiratory Medicine, Allergy and Rheumatic Disease, Osaka University Graduate School of Medicine and Department of Immunopathology, WPI Immunology Frontier Research Center, Osaka University, Osaka; Department of Rheumatology and Clinical Immunology, Saitama Medical Center, Saitama Medical University, Saitama; Department of Internal Medicine, Division of Endocrinology and Metabolism, Hematology, Rheumatology and Respiratory Medicine, Faculty of Medicine, Kagawa University; Department of Rheumatology, Utazu-Hama Clinic, Kagawa; Department of Hematology and Rheumatology, Tohoku University Hospital, Sendai; Division of Rheumatology, Department of Medicine, Showa University School of Medicine; Division of Rheumatology, Department of Internal Medicine, Toho University School of Medicine, Tokyo; Unit of Translational Medicine, Department of Immunology and Rheumatology, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki; Department of Rheumatosurgery, Osaka City University, Graduate School of Medicine, Osaka; Department of Internal Medicine and Rheumatology, National Hospital Organization Kyushu Medical Center, Fukuoka; Department of Rheumatology, Seirei Hamamatsu General Hospital, Shizuoka; Munakata Yasuhiko Clinic, Miyagi; Department of Rheumatology, Niigata Rheumatic Center, Niigata; Osaka Rheumatology Clinic, Osaka; Third Department of Internal Medicine, Hamamatsu University School of Medicine, Shizuoka; Department of Orthopedic Surgery, Fukui General Hospital, Fukui; Division of Rheumatology, Department of Internal Medicine, Hyogo College of Medicine, Hyogo; Department of Orthopedic Surgery, Osaka University Graduate School of Medicine, Osaka; Shono Rheumatology Clinic, Fukuoka; First Department of Internal Medicine, Sapporo Medical University School of Medicine, Hokkaido; The First Department of Internal Medicine, School of Medicine, University of Occupational and Environmental Health, Fukuoka; Department of Medicine and Biosystemic Science, Kyushu University Graduate School of Medical Sciences, Fukuoka; Chugai Pharmaceutical Co. Ltd., Tokyo, Japan. Funded by Chugai Pharmaceutical Co. Ltd. Support for third-party writing assistance for this manuscript, provided by Denise Kenski, PhD, of Health Interactions, was supported by Genentech Inc. A. Ogata has received consulting fees, speaking fees, and/or honoraria from Chugai Pharmaceutical. N. Nishimoto has received consulting fees, speaking fees, and patent or license-related income from Chugai Pharmaceutical. Y. Tanaka has received speaking fees from Chugai Pharmaceutical. A. Nomura is employed by Chugai Pharmaceutical. A. Ogata, MD, PhD, Osaka University Graduate School of Medicine and Osaka University; K. Amano, MD, PhD, Saitama Medical Centre, Saitama Medical University; H. Dobashi, MD, PhD, Kagawa University; M. Inoo, MD, PhD, Utazu-Hama Clinic; T. Ishii, MD, PhD, Tohoku University Hospital; T. Kasama, MD, PhD, Showa University School of Medicine; S. Kawai, MD, PhD, Toho University School of Medicine; A. Kawakami, MD, PhD, Nagasaki University Graduate School of Biomedical Sciences; T. Koike, MD, PhD, Osaka City University Medical School; H. Miyahara, MD, PhD, National Hospital Organization Kyushu Medical Center; T. Miyamoto, MD, Seirei Hamamatsu General Hospital; Y. Munakata, MD, PhD, Munakata Yasuhiko Clinic; A. Murasawa, MD, PhD, Niigata Rheumatic Center; N. Nishimoto, MD, PhD, Osaka Rheumatology Clinic; N. Ogawa, MD, PhD, Hamamatsu University School of Medicine; T. Ojima, MD, PhD, Fukui General Hospital; H. Sano, MD, PhD, Hyogo College of Medicine; K. Shi, MD, PhD, Osaka University Graduate School of Medicine; E. Shono, MD, PhD, Shono Rheumatology Clinic; E. Suematsu, MD, National Hospital Organization Kyushu Medical Center; K.H. Takahashi, MD, PhD, Sapporo Medical University School of Medicine; Y. Tanaka, MD, PhD, University of Occupation and Environmental Health; H. Tsukamoto, MD, PhD, Kyushu University Graduate School of Medical Sciences; A. Nomura, MSc, Chugai Pharmaceutical. Address correspondence to Dr. A. Ogata, Department of Respiratory Medicine, Allergy and Rheumatic Disease, Osaka University Graduate School of Medicine, 2-2, Yamadaoka, Suita, Osaka 565-0871, Japan. E-mail: ogata@imed3.med.osaka-u.ac.jp Accepted for publication January 27, 2015.
Koichi Amano
From the Department of Respiratory Medicine, Allergy and Rheumatic Disease, Osaka University Graduate School of Medicine and Department of Immunopathology, WPI Immunology Frontier Research Center, Osaka University, Osaka; Department of Rheumatology and Clinical Immunology, Saitama Medical Center, Saitama Medical University, Saitama; Department of Internal Medicine, Division of Endocrinology and Metabolism, Hematology, Rheumatology and Respiratory Medicine, Faculty of Medicine, Kagawa University; Department of Rheumatology, Utazu-Hama Clinic, Kagawa; Department of Hematology and Rheumatology, Tohoku University Hospital, Sendai; Division of Rheumatology, Department of Medicine, Showa University School of Medicine; Division of Rheumatology, Department of Internal Medicine, Toho University School of Medicine, Tokyo; Unit of Translational Medicine, Department of Immunology and Rheumatology, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki; Department of Rheumatosurgery, Osaka City University, Graduate School of Medicine, Osaka; Department of Internal Medicine and Rheumatology, National Hospital Organization Kyushu Medical Center, Fukuoka; Department of Rheumatology, Seirei Hamamatsu General Hospital, Shizuoka; Munakata Yasuhiko Clinic, Miyagi; Department of Rheumatology, Niigata Rheumatic Center, Niigata; Osaka Rheumatology Clinic, Osaka; Third Department of Internal Medicine, Hamamatsu University School of Medicine, Shizuoka; Department of Orthopedic Surgery, Fukui General Hospital, Fukui; Division of Rheumatology, Department of Internal Medicine, Hyogo College of Medicine, Hyogo; Department of Orthopedic Surgery, Osaka University Graduate School of Medicine, Osaka; Shono Rheumatology Clinic, Fukuoka; First Department of Internal Medicine, Sapporo Medical University School of Medicine, Hokkaido; The First Department of Internal Medicine, School of Medicine, University of Occupational and Environmental Health, Fukuoka; Department of Medicine and Biosystemic Science, Kyushu University Graduate School of Medical Sciences, Fukuoka; Chugai Pharmaceutical Co. Ltd., Tokyo, Japan. Funded by Chugai Pharmaceutical Co. Ltd. Support for third-party writing assistance for this manuscript, provided by Denise Kenski, PhD, of Health Interactions, was supported by Genentech Inc. A. Ogata has received consulting fees, speaking fees, and/or honoraria from Chugai Pharmaceutical. N. Nishimoto has received consulting fees, speaking fees, and patent or license-related income from Chugai Pharmaceutical. Y. Tanaka has received speaking fees from Chugai Pharmaceutical. A. Nomura is employed by Chugai Pharmaceutical. A. Ogata, MD, PhD, Osaka University Graduate School of Medicine and Osaka University; K. Amano, MD, PhD, Saitama Medical Centre, Saitama Medical University; H. Dobashi, MD, PhD, Kagawa University; M. Inoo, MD, PhD, Utazu-Hama Clinic; T. Ishii, MD, PhD, Tohoku University Hospital; T. Kasama, MD, PhD, Showa University School of Medicine; S. Kawai, MD, PhD, Toho University School of Medicine; A. Kawakami, MD, PhD, Nagasaki University Graduate School of Biomedical Sciences; T. Koike, MD, PhD, Osaka City University Medical School; H. Miyahara, MD, PhD, National Hospital Organization Kyushu Medical Center; T. Miyamoto, MD, Seirei Hamamatsu General Hospital; Y. Munakata, MD, PhD, Munakata Yasuhiko Clinic; A. Murasawa, MD, PhD, Niigata Rheumatic Center; N. Nishimoto, MD, PhD, Osaka Rheumatology Clinic; N. Ogawa, MD, PhD, Hamamatsu University School of Medicine; T. Ojima, MD, PhD, Fukui General Hospital; H. Sano, MD, PhD, Hyogo College of Medicine; K. Shi, MD, PhD, Osaka University Graduate School of Medicine; E. Shono, MD, PhD, Shono Rheumatology Clinic; E. Suematsu, MD, National Hospital Organization Kyushu Medical Center; K.H. Takahashi, MD, PhD, Sapporo Medical University School of Medicine; Y. Tanaka, MD, PhD, University of Occupation and Environmental Health; H. Tsukamoto, MD, PhD, Kyushu University Graduate School of Medical Sciences; A. Nomura, MSc, Chugai Pharmaceutical. Address correspondence to Dr. A. Ogata, Department of Respiratory Medicine, Allergy and Rheumatic Disease, Osaka University Graduate School of Medicine, 2-2, Yamadaoka, Suita, Osaka 565-0871, Japan. E-mail: ogata@imed3.med.osaka-u.ac.jp Accepted for publication January 27, 2015.
Hiroaki Dobashi
From the Department of Respiratory Medicine, Allergy and Rheumatic Disease, Osaka University Graduate School of Medicine and Department of Immunopathology, WPI Immunology Frontier Research Center, Osaka University, Osaka; Department of Rheumatology and Clinical Immunology, Saitama Medical Center, Saitama Medical University, Saitama; Department of Internal Medicine, Division of Endocrinology and Metabolism, Hematology, Rheumatology and Respiratory Medicine, Faculty of Medicine, Kagawa University; Department of Rheumatology, Utazu-Hama Clinic, Kagawa; Department of Hematology and Rheumatology, Tohoku University Hospital, Sendai; Division of Rheumatology, Department of Medicine, Showa University School of Medicine; Division of Rheumatology, Department of Internal Medicine, Toho University School of Medicine, Tokyo; Unit of Translational Medicine, Department of Immunology and Rheumatology, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki; Department of Rheumatosurgery, Osaka City University, Graduate School of Medicine, Osaka; Department of Internal Medicine and Rheumatology, National Hospital Organization Kyushu Medical Center, Fukuoka; Department of Rheumatology, Seirei Hamamatsu General Hospital, Shizuoka; Munakata Yasuhiko Clinic, Miyagi; Department of Rheumatology, Niigata Rheumatic Center, Niigata; Osaka Rheumatology Clinic, Osaka; Third Department of Internal Medicine, Hamamatsu University School of Medicine, Shizuoka; Department of Orthopedic Surgery, Fukui General Hospital, Fukui; Division of Rheumatology, Department of Internal Medicine, Hyogo College of Medicine, Hyogo; Department of Orthopedic Surgery, Osaka University Graduate School of Medicine, Osaka; Shono Rheumatology Clinic, Fukuoka; First Department of Internal Medicine, Sapporo Medical University School of Medicine, Hokkaido; The First Department of Internal Medicine, School of Medicine, University of Occupational and Environmental Health, Fukuoka; Department of Medicine and Biosystemic Science, Kyushu University Graduate School of Medical Sciences, Fukuoka; Chugai Pharmaceutical Co. Ltd., Tokyo, Japan. Funded by Chugai Pharmaceutical Co. Ltd. Support for third-party writing assistance for this manuscript, provided by Denise Kenski, PhD, of Health Interactions, was supported by Genentech Inc. A. Ogata has received consulting fees, speaking fees, and/or honoraria from Chugai Pharmaceutical. N. Nishimoto has received consulting fees, speaking fees, and patent or license-related income from Chugai Pharmaceutical. Y. Tanaka has received speaking fees from Chugai Pharmaceutical. A. Nomura is employed by Chugai Pharmaceutical. A. Ogata, MD, PhD, Osaka University Graduate School of Medicine and Osaka University; K. Amano, MD, PhD, Saitama Medical Centre, Saitama Medical University; H. Dobashi, MD, PhD, Kagawa University; M. Inoo, MD, PhD, Utazu-Hama Clinic; T. Ishii, MD, PhD, Tohoku University Hospital; T. Kasama, MD, PhD, Showa University School of Medicine; S. Kawai, MD, PhD, Toho University School of Medicine; A. Kawakami, MD, PhD, Nagasaki University Graduate School of Biomedical Sciences; T. Koike, MD, PhD, Osaka City University Medical School; H. Miyahara, MD, PhD, National Hospital Organization Kyushu Medical Center; T. Miyamoto, MD, Seirei Hamamatsu General Hospital; Y. Munakata, MD, PhD, Munakata Yasuhiko Clinic; A. Murasawa, MD, PhD, Niigata Rheumatic Center; N. Nishimoto, MD, PhD, Osaka Rheumatology Clinic; N. Ogawa, MD, PhD, Hamamatsu University School of Medicine; T. Ojima, MD, PhD, Fukui General Hospital; H. Sano, MD, PhD, Hyogo College of Medicine; K. Shi, MD, PhD, Osaka University Graduate School of Medicine; E. Shono, MD, PhD, Shono Rheumatology Clinic; E. Suematsu, MD, National Hospital Organization Kyushu Medical Center; K.H. Takahashi, MD, PhD, Sapporo Medical University School of Medicine; Y. Tanaka, MD, PhD, University of Occupation and Environmental Health; H. Tsukamoto, MD, PhD, Kyushu University Graduate School of Medical Sciences; A. Nomura, MSc, Chugai Pharmaceutical. Address correspondence to Dr. A. Ogata, Department of Respiratory Medicine, Allergy and Rheumatic Disease, Osaka University Graduate School of Medicine, 2-2, Yamadaoka, Suita, Osaka 565-0871, Japan. E-mail: ogata@imed3.med.osaka-u.ac.jp Accepted for publication January 27, 2015.
Masayuki Inoo
From the Department of Respiratory Medicine, Allergy and Rheumatic Disease, Osaka University Graduate School of Medicine and Department of Immunopathology, WPI Immunology Frontier Research Center, Osaka University, Osaka; Department of Rheumatology and Clinical Immunology, Saitama Medical Center, Saitama Medical University, Saitama; Department of Internal Medicine, Division of Endocrinology and Metabolism, Hematology, Rheumatology and Respiratory Medicine, Faculty of Medicine, Kagawa University; Department of Rheumatology, Utazu-Hama Clinic, Kagawa; Department of Hematology and Rheumatology, Tohoku University Hospital, Sendai; Division of Rheumatology, Department of Medicine, Showa University School of Medicine; Division of Rheumatology, Department of Internal Medicine, Toho University School of Medicine, Tokyo; Unit of Translational Medicine, Department of Immunology and Rheumatology, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki; Department of Rheumatosurgery, Osaka City University, Graduate School of Medicine, Osaka; Department of Internal Medicine and Rheumatology, National Hospital Organization Kyushu Medical Center, Fukuoka; Department of Rheumatology, Seirei Hamamatsu General Hospital, Shizuoka; Munakata Yasuhiko Clinic, Miyagi; Department of Rheumatology, Niigata Rheumatic Center, Niigata; Osaka Rheumatology Clinic, Osaka; Third Department of Internal Medicine, Hamamatsu University School of Medicine, Shizuoka; Department of Orthopedic Surgery, Fukui General Hospital, Fukui; Division of Rheumatology, Department of Internal Medicine, Hyogo College of Medicine, Hyogo; Department of Orthopedic Surgery, Osaka University Graduate School of Medicine, Osaka; Shono Rheumatology Clinic, Fukuoka; First Department of Internal Medicine, Sapporo Medical University School of Medicine, Hokkaido; The First Department of Internal Medicine, School of Medicine, University of Occupational and Environmental Health, Fukuoka; Department of Medicine and Biosystemic Science, Kyushu University Graduate School of Medical Sciences, Fukuoka; Chugai Pharmaceutical Co. Ltd., Tokyo, Japan. Funded by Chugai Pharmaceutical Co. Ltd. Support for third-party writing assistance for this manuscript, provided by Denise Kenski, PhD, of Health Interactions, was supported by Genentech Inc. A. Ogata has received consulting fees, speaking fees, and/or honoraria from Chugai Pharmaceutical. N. Nishimoto has received consulting fees, speaking fees, and patent or license-related income from Chugai Pharmaceutical. Y. Tanaka has received speaking fees from Chugai Pharmaceutical. A. Nomura is employed by Chugai Pharmaceutical. A. Ogata, MD, PhD, Osaka University Graduate School of Medicine and Osaka University; K. Amano, MD, PhD, Saitama Medical Centre, Saitama Medical University; H. Dobashi, MD, PhD, Kagawa University; M. Inoo, MD, PhD, Utazu-Hama Clinic; T. Ishii, MD, PhD, Tohoku University Hospital; T. Kasama, MD, PhD, Showa University School of Medicine; S. Kawai, MD, PhD, Toho University School of Medicine; A. Kawakami, MD, PhD, Nagasaki University Graduate School of Biomedical Sciences; T. Koike, MD, PhD, Osaka City University Medical School; H. Miyahara, MD, PhD, National Hospital Organization Kyushu Medical Center; T. Miyamoto, MD, Seirei Hamamatsu General Hospital; Y. Munakata, MD, PhD, Munakata Yasuhiko Clinic; A. Murasawa, MD, PhD, Niigata Rheumatic Center; N. Nishimoto, MD, PhD, Osaka Rheumatology Clinic; N. Ogawa, MD, PhD, Hamamatsu University School of Medicine; T. Ojima, MD, PhD, Fukui General Hospital; H. Sano, MD, PhD, Hyogo College of Medicine; K. Shi, MD, PhD, Osaka University Graduate School of Medicine; E. Shono, MD, PhD, Shono Rheumatology Clinic; E. Suematsu, MD, National Hospital Organization Kyushu Medical Center; K.H. Takahashi, MD, PhD, Sapporo Medical University School of Medicine; Y. Tanaka, MD, PhD, University of Occupation and Environmental Health; H. Tsukamoto, MD, PhD, Kyushu University Graduate School of Medical Sciences; A. Nomura, MSc, Chugai Pharmaceutical. Address correspondence to Dr. A. Ogata, Department of Respiratory Medicine, Allergy and Rheumatic Disease, Osaka University Graduate School of Medicine, 2-2, Yamadaoka, Suita, Osaka 565-0871, Japan. E-mail: ogata@imed3.med.osaka-u.ac.jp Accepted for publication January 27, 2015.
Tomonori Ishii
From the Department of Respiratory Medicine, Allergy and Rheumatic Disease, Osaka University Graduate School of Medicine and Department of Immunopathology, WPI Immunology Frontier Research Center, Osaka University, Osaka; Department of Rheumatology and Clinical Immunology, Saitama Medical Center, Saitama Medical University, Saitama; Department of Internal Medicine, Division of Endocrinology and Metabolism, Hematology, Rheumatology and Respiratory Medicine, Faculty of Medicine, Kagawa University; Department of Rheumatology, Utazu-Hama Clinic, Kagawa; Department of Hematology and Rheumatology, Tohoku University Hospital, Sendai; Division of Rheumatology, Department of Medicine, Showa University School of Medicine; Division of Rheumatology, Department of Internal Medicine, Toho University School of Medicine, Tokyo; Unit of Translational Medicine, Department of Immunology and Rheumatology, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki; Department of Rheumatosurgery, Osaka City University, Graduate School of Medicine, Osaka; Department of Internal Medicine and Rheumatology, National Hospital Organization Kyushu Medical Center, Fukuoka; Department of Rheumatology, Seirei Hamamatsu General Hospital, Shizuoka; Munakata Yasuhiko Clinic, Miyagi; Department of Rheumatology, Niigata Rheumatic Center, Niigata; Osaka Rheumatology Clinic, Osaka; Third Department of Internal Medicine, Hamamatsu University School of Medicine, Shizuoka; Department of Orthopedic Surgery, Fukui General Hospital, Fukui; Division of Rheumatology, Department of Internal Medicine, Hyogo College of Medicine, Hyogo; Department of Orthopedic Surgery, Osaka University Graduate School of Medicine, Osaka; Shono Rheumatology Clinic, Fukuoka; First Department of Internal Medicine, Sapporo Medical University School of Medicine, Hokkaido; The First Department of Internal Medicine, School of Medicine, University of Occupational and Environmental Health, Fukuoka; Department of Medicine and Biosystemic Science, Kyushu University Graduate School of Medical Sciences, Fukuoka; Chugai Pharmaceutical Co. Ltd., Tokyo, Japan. Funded by Chugai Pharmaceutical Co. Ltd. Support for third-party writing assistance for this manuscript, provided by Denise Kenski, PhD, of Health Interactions, was supported by Genentech Inc. A. Ogata has received consulting fees, speaking fees, and/or honoraria from Chugai Pharmaceutical. N. Nishimoto has received consulting fees, speaking fees, and patent or license-related income from Chugai Pharmaceutical. Y. Tanaka has received speaking fees from Chugai Pharmaceutical. A. Nomura is employed by Chugai Pharmaceutical. A. Ogata, MD, PhD, Osaka University Graduate School of Medicine and Osaka University; K. Amano, MD, PhD, Saitama Medical Centre, Saitama Medical University; H. Dobashi, MD, PhD, Kagawa University; M. Inoo, MD, PhD, Utazu-Hama Clinic; T. Ishii, MD, PhD, Tohoku University Hospital; T. Kasama, MD, PhD, Showa University School of Medicine; S. Kawai, MD, PhD, Toho University School of Medicine; A. Kawakami, MD, PhD, Nagasaki University Graduate School of Biomedical Sciences; T. Koike, MD, PhD, Osaka City University Medical School; H. Miyahara, MD, PhD, National Hospital Organization Kyushu Medical Center; T. Miyamoto, MD, Seirei Hamamatsu General Hospital; Y. Munakata, MD, PhD, Munakata Yasuhiko Clinic; A. Murasawa, MD, PhD, Niigata Rheumatic Center; N. Nishimoto, MD, PhD, Osaka Rheumatology Clinic; N. Ogawa, MD, PhD, Hamamatsu University School of Medicine; T. Ojima, MD, PhD, Fukui General Hospital; H. Sano, MD, PhD, Hyogo College of Medicine; K. Shi, MD, PhD, Osaka University Graduate School of Medicine; E. Shono, MD, PhD, Shono Rheumatology Clinic; E. Suematsu, MD, National Hospital Organization Kyushu Medical Center; K.H. Takahashi, MD, PhD, Sapporo Medical University School of Medicine; Y. Tanaka, MD, PhD, University of Occupation and Environmental Health; H. Tsukamoto, MD, PhD, Kyushu University Graduate School of Medical Sciences; A. Nomura, MSc, Chugai Pharmaceutical. Address correspondence to Dr. A. Ogata, Department of Respiratory Medicine, Allergy and Rheumatic Disease, Osaka University Graduate School of Medicine, 2-2, Yamadaoka, Suita, Osaka 565-0871, Japan. E-mail: ogata@imed3.med.osaka-u.ac.jp Accepted for publication January 27, 2015.
Tsuyoshi Kasama
From the Department of Respiratory Medicine, Allergy and Rheumatic Disease, Osaka University Graduate School of Medicine and Department of Immunopathology, WPI Immunology Frontier Research Center, Osaka University, Osaka; Department of Rheumatology and Clinical Immunology, Saitama Medical Center, Saitama Medical University, Saitama; Department of Internal Medicine, Division of Endocrinology and Metabolism, Hematology, Rheumatology and Respiratory Medicine, Faculty of Medicine, Kagawa University; Department of Rheumatology, Utazu-Hama Clinic, Kagawa; Department of Hematology and Rheumatology, Tohoku University Hospital, Sendai; Division of Rheumatology, Department of Medicine, Showa University School of Medicine; Division of Rheumatology, Department of Internal Medicine, Toho University School of Medicine, Tokyo; Unit of Translational Medicine, Department of Immunology and Rheumatology, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki; Department of Rheumatosurgery, Osaka City University, Graduate School of Medicine, Osaka; Department of Internal Medicine and Rheumatology, National Hospital Organization Kyushu Medical Center, Fukuoka; Department of Rheumatology, Seirei Hamamatsu General Hospital, Shizuoka; Munakata Yasuhiko Clinic, Miyagi; Department of Rheumatology, Niigata Rheumatic Center, Niigata; Osaka Rheumatology Clinic, Osaka; Third Department of Internal Medicine, Hamamatsu University School of Medicine, Shizuoka; Department of Orthopedic Surgery, Fukui General Hospital, Fukui; Division of Rheumatology, Department of Internal Medicine, Hyogo College of Medicine, Hyogo; Department of Orthopedic Surgery, Osaka University Graduate School of Medicine, Osaka; Shono Rheumatology Clinic, Fukuoka; First Department of Internal Medicine, Sapporo Medical University School of Medicine, Hokkaido; The First Department of Internal Medicine, School of Medicine, University of Occupational and Environmental Health, Fukuoka; Department of Medicine and Biosystemic Science, Kyushu University Graduate School of Medical Sciences, Fukuoka; Chugai Pharmaceutical Co. Ltd., Tokyo, Japan. Funded by Chugai Pharmaceutical Co. Ltd. Support for third-party writing assistance for this manuscript, provided by Denise Kenski, PhD, of Health Interactions, was supported by Genentech Inc. A. Ogata has received consulting fees, speaking fees, and/or honoraria from Chugai Pharmaceutical. N. Nishimoto has received consulting fees, speaking fees, and patent or license-related income from Chugai Pharmaceutical. Y. Tanaka has received speaking fees from Chugai Pharmaceutical. A. Nomura is employed by Chugai Pharmaceutical. A. Ogata, MD, PhD, Osaka University Graduate School of Medicine and Osaka University; K. Amano, MD, PhD, Saitama Medical Centre, Saitama Medical University; H. Dobashi, MD, PhD, Kagawa University; M. Inoo, MD, PhD, Utazu-Hama Clinic; T. Ishii, MD, PhD, Tohoku University Hospital; T. Kasama, MD, PhD, Showa University School of Medicine; S. Kawai, MD, PhD, Toho University School of Medicine; A. Kawakami, MD, PhD, Nagasaki University Graduate School of Biomedical Sciences; T. Koike, MD, PhD, Osaka City University Medical School; H. Miyahara, MD, PhD, National Hospital Organization Kyushu Medical Center; T. Miyamoto, MD, Seirei Hamamatsu General Hospital; Y. Munakata, MD, PhD, Munakata Yasuhiko Clinic; A. Murasawa, MD, PhD, Niigata Rheumatic Center; N. Nishimoto, MD, PhD, Osaka Rheumatology Clinic; N. Ogawa, MD, PhD, Hamamatsu University School of Medicine; T. Ojima, MD, PhD, Fukui General Hospital; H. Sano, MD, PhD, Hyogo College of Medicine; K. Shi, MD, PhD, Osaka University Graduate School of Medicine; E. Shono, MD, PhD, Shono Rheumatology Clinic; E. Suematsu, MD, National Hospital Organization Kyushu Medical Center; K.H. Takahashi, MD, PhD, Sapporo Medical University School of Medicine; Y. Tanaka, MD, PhD, University of Occupation and Environmental Health; H. Tsukamoto, MD, PhD, Kyushu University Graduate School of Medical Sciences; A. Nomura, MSc, Chugai Pharmaceutical. Address correspondence to Dr. A. Ogata, Department of Respiratory Medicine, Allergy and Rheumatic Disease, Osaka University Graduate School of Medicine, 2-2, Yamadaoka, Suita, Osaka 565-0871, Japan. E-mail: ogata@imed3.med.osaka-u.ac.jp Accepted for publication January 27, 2015.
Shinichi Kawai
From the Department of Respiratory Medicine, Allergy and Rheumatic Disease, Osaka University Graduate School of Medicine and Department of Immunopathology, WPI Immunology Frontier Research Center, Osaka University, Osaka; Department of Rheumatology and Clinical Immunology, Saitama Medical Center, Saitama Medical University, Saitama; Department of Internal Medicine, Division of Endocrinology and Metabolism, Hematology, Rheumatology and Respiratory Medicine, Faculty of Medicine, Kagawa University; Department of Rheumatology, Utazu-Hama Clinic, Kagawa; Department of Hematology and Rheumatology, Tohoku University Hospital, Sendai; Division of Rheumatology, Department of Medicine, Showa University School of Medicine; Division of Rheumatology, Department of Internal Medicine, Toho University School of Medicine, Tokyo; Unit of Translational Medicine, Department of Immunology and Rheumatology, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki; Department of Rheumatosurgery, Osaka City University, Graduate School of Medicine, Osaka; Department of Internal Medicine and Rheumatology, National Hospital Organization Kyushu Medical Center, Fukuoka; Department of Rheumatology, Seirei Hamamatsu General Hospital, Shizuoka; Munakata Yasuhiko Clinic, Miyagi; Department of Rheumatology, Niigata Rheumatic Center, Niigata; Osaka Rheumatology Clinic, Osaka; Third Department of Internal Medicine, Hamamatsu University School of Medicine, Shizuoka; Department of Orthopedic Surgery, Fukui General Hospital, Fukui; Division of Rheumatology, Department of Internal Medicine, Hyogo College of Medicine, Hyogo; Department of Orthopedic Surgery, Osaka University Graduate School of Medicine, Osaka; Shono Rheumatology Clinic, Fukuoka; First Department of Internal Medicine, Sapporo Medical University School of Medicine, Hokkaido; The First Department of Internal Medicine, School of Medicine, University of Occupational and Environmental Health, Fukuoka; Department of Medicine and Biosystemic Science, Kyushu University Graduate School of Medical Sciences, Fukuoka; Chugai Pharmaceutical Co. Ltd., Tokyo, Japan. Funded by Chugai Pharmaceutical Co. Ltd. Support for third-party writing assistance for this manuscript, provided by Denise Kenski, PhD, of Health Interactions, was supported by Genentech Inc. A. Ogata has received consulting fees, speaking fees, and/or honoraria from Chugai Pharmaceutical. N. Nishimoto has received consulting fees, speaking fees, and patent or license-related income from Chugai Pharmaceutical. Y. Tanaka has received speaking fees from Chugai Pharmaceutical. A. Nomura is employed by Chugai Pharmaceutical. A. Ogata, MD, PhD, Osaka University Graduate School of Medicine and Osaka University; K. Amano, MD, PhD, Saitama Medical Centre, Saitama Medical University; H. Dobashi, MD, PhD, Kagawa University; M. Inoo, MD, PhD, Utazu-Hama Clinic; T. Ishii, MD, PhD, Tohoku University Hospital; T. Kasama, MD, PhD, Showa University School of Medicine; S. Kawai, MD, PhD, Toho University School of Medicine; A. Kawakami, MD, PhD, Nagasaki University Graduate School of Biomedical Sciences; T. Koike, MD, PhD, Osaka City University Medical School; H. Miyahara, MD, PhD, National Hospital Organization Kyushu Medical Center; T. Miyamoto, MD, Seirei Hamamatsu General Hospital; Y. Munakata, MD, PhD, Munakata Yasuhiko Clinic; A. Murasawa, MD, PhD, Niigata Rheumatic Center; N. Nishimoto, MD, PhD, Osaka Rheumatology Clinic; N. Ogawa, MD, PhD, Hamamatsu University School of Medicine; T. Ojima, MD, PhD, Fukui General Hospital; H. Sano, MD, PhD, Hyogo College of Medicine; K. Shi, MD, PhD, Osaka University Graduate School of Medicine; E. Shono, MD, PhD, Shono Rheumatology Clinic; E. Suematsu, MD, National Hospital Organization Kyushu Medical Center; K.H. Takahashi, MD, PhD, Sapporo Medical University School of Medicine; Y. Tanaka, MD, PhD, University of Occupation and Environmental Health; H. Tsukamoto, MD, PhD, Kyushu University Graduate School of Medical Sciences; A. Nomura, MSc, Chugai Pharmaceutical. Address correspondence to Dr. A. Ogata, Department of Respiratory Medicine, Allergy and Rheumatic Disease, Osaka University Graduate School of Medicine, 2-2, Yamadaoka, Suita, Osaka 565-0871, Japan. E-mail: ogata@imed3.med.osaka-u.ac.jp Accepted for publication January 27, 2015.
Atsushi Kawakami
From the Department of Respiratory Medicine, Allergy and Rheumatic Disease, Osaka University Graduate School of Medicine and Department of Immunopathology, WPI Immunology Frontier Research Center, Osaka University, Osaka; Department of Rheumatology and Clinical Immunology, Saitama Medical Center, Saitama Medical University, Saitama; Department of Internal Medicine, Division of Endocrinology and Metabolism, Hematology, Rheumatology and Respiratory Medicine, Faculty of Medicine, Kagawa University; Department of Rheumatology, Utazu-Hama Clinic, Kagawa; Department of Hematology and Rheumatology, Tohoku University Hospital, Sendai; Division of Rheumatology, Department of Medicine, Showa University School of Medicine; Division of Rheumatology, Department of Internal Medicine, Toho University School of Medicine, Tokyo; Unit of Translational Medicine, Department of Immunology and Rheumatology, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki; Department of Rheumatosurgery, Osaka City University, Graduate School of Medicine, Osaka; Department of Internal Medicine and Rheumatology, National Hospital Organization Kyushu Medical Center, Fukuoka; Department of Rheumatology, Seirei Hamamatsu General Hospital, Shizuoka; Munakata Yasuhiko Clinic, Miyagi; Department of Rheumatology, Niigata Rheumatic Center, Niigata; Osaka Rheumatology Clinic, Osaka; Third Department of Internal Medicine, Hamamatsu University School of Medicine, Shizuoka; Department of Orthopedic Surgery, Fukui General Hospital, Fukui; Division of Rheumatology, Department of Internal Medicine, Hyogo College of Medicine, Hyogo; Department of Orthopedic Surgery, Osaka University Graduate School of Medicine, Osaka; Shono Rheumatology Clinic, Fukuoka; First Department of Internal Medicine, Sapporo Medical University School of Medicine, Hokkaido; The First Department of Internal Medicine, School of Medicine, University of Occupational and Environmental Health, Fukuoka; Department of Medicine and Biosystemic Science, Kyushu University Graduate School of Medical Sciences, Fukuoka; Chugai Pharmaceutical Co. Ltd., Tokyo, Japan. Funded by Chugai Pharmaceutical Co. Ltd. Support for third-party writing assistance for this manuscript, provided by Denise Kenski, PhD, of Health Interactions, was supported by Genentech Inc. A. Ogata has received consulting fees, speaking fees, and/or honoraria from Chugai Pharmaceutical. N. Nishimoto has received consulting fees, speaking fees, and patent or license-related income from Chugai Pharmaceutical. Y. Tanaka has received speaking fees from Chugai Pharmaceutical. A. Nomura is employed by Chugai Pharmaceutical. A. Ogata, MD, PhD, Osaka University Graduate School of Medicine and Osaka University; K. Amano, MD, PhD, Saitama Medical Centre, Saitama Medical University; H. Dobashi, MD, PhD, Kagawa University; M. Inoo, MD, PhD, Utazu-Hama Clinic; T. Ishii, MD, PhD, Tohoku University Hospital; T. Kasama, MD, PhD, Showa University School of Medicine; S. Kawai, MD, PhD, Toho University School of Medicine; A. Kawakami, MD, PhD, Nagasaki University Graduate School of Biomedical Sciences; T. Koike, MD, PhD, Osaka City University Medical School; H. Miyahara, MD, PhD, National Hospital Organization Kyushu Medical Center; T. Miyamoto, MD, Seirei Hamamatsu General Hospital; Y. Munakata, MD, PhD, Munakata Yasuhiko Clinic; A. Murasawa, MD, PhD, Niigata Rheumatic Center; N. Nishimoto, MD, PhD, Osaka Rheumatology Clinic; N. Ogawa, MD, PhD, Hamamatsu University School of Medicine; T. Ojima, MD, PhD, Fukui General Hospital; H. Sano, MD, PhD, Hyogo College of Medicine; K. Shi, MD, PhD, Osaka University Graduate School of Medicine; E. Shono, MD, PhD, Shono Rheumatology Clinic; E. Suematsu, MD, National Hospital Organization Kyushu Medical Center; K.H. Takahashi, MD, PhD, Sapporo Medical University School of Medicine; Y. Tanaka, MD, PhD, University of Occupation and Environmental Health; H. Tsukamoto, MD, PhD, Kyushu University Graduate School of Medical Sciences; A. Nomura, MSc, Chugai Pharmaceutical. Address correspondence to Dr. A. Ogata, Department of Respiratory Medicine, Allergy and Rheumatic Disease, Osaka University Graduate School of Medicine, 2-2, Yamadaoka, Suita, Osaka 565-0871, Japan. E-mail: ogata@imed3.med.osaka-u.ac.jp Accepted for publication January 27, 2015.
Tatsuya Koike
From the Department of Respiratory Medicine, Allergy and Rheumatic Disease, Osaka University Graduate School of Medicine and Department of Immunopathology, WPI Immunology Frontier Research Center, Osaka University, Osaka; Department of Rheumatology and Clinical Immunology, Saitama Medical Center, Saitama Medical University, Saitama; Department of Internal Medicine, Division of Endocrinology and Metabolism, Hematology, Rheumatology and Respiratory Medicine, Faculty of Medicine, Kagawa University; Department of Rheumatology, Utazu-Hama Clinic, Kagawa; Department of Hematology and Rheumatology, Tohoku University Hospital, Sendai; Division of Rheumatology, Department of Medicine, Showa University School of Medicine; Division of Rheumatology, Department of Internal Medicine, Toho University School of Medicine, Tokyo; Unit of Translational Medicine, Department of Immunology and Rheumatology, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki; Department of Rheumatosurgery, Osaka City University, Graduate School of Medicine, Osaka; Department of Internal Medicine and Rheumatology, National Hospital Organization Kyushu Medical Center, Fukuoka; Department of Rheumatology, Seirei Hamamatsu General Hospital, Shizuoka; Munakata Yasuhiko Clinic, Miyagi; Department of Rheumatology, Niigata Rheumatic Center, Niigata; Osaka Rheumatology Clinic, Osaka; Third Department of Internal Medicine, Hamamatsu University School of Medicine, Shizuoka; Department of Orthopedic Surgery, Fukui General Hospital, Fukui; Division of Rheumatology, Department of Internal Medicine, Hyogo College of Medicine, Hyogo; Department of Orthopedic Surgery, Osaka University Graduate School of Medicine, Osaka; Shono Rheumatology Clinic, Fukuoka; First Department of Internal Medicine, Sapporo Medical University School of Medicine, Hokkaido; The First Department of Internal Medicine, School of Medicine, University of Occupational and Environmental Health, Fukuoka; Department of Medicine and Biosystemic Science, Kyushu University Graduate School of Medical Sciences, Fukuoka; Chugai Pharmaceutical Co. Ltd., Tokyo, Japan. Funded by Chugai Pharmaceutical Co. Ltd. Support for third-party writing assistance for this manuscript, provided by Denise Kenski, PhD, of Health Interactions, was supported by Genentech Inc. A. Ogata has received consulting fees, speaking fees, and/or honoraria from Chugai Pharmaceutical. N. Nishimoto has received consulting fees, speaking fees, and patent or license-related income from Chugai Pharmaceutical. Y. Tanaka has received speaking fees from Chugai Pharmaceutical. A. Nomura is employed by Chugai Pharmaceutical. A. Ogata, MD, PhD, Osaka University Graduate School of Medicine and Osaka University; K. Amano, MD, PhD, Saitama Medical Centre, Saitama Medical University; H. Dobashi, MD, PhD, Kagawa University; M. Inoo, MD, PhD, Utazu-Hama Clinic; T. Ishii, MD, PhD, Tohoku University Hospital; T. Kasama, MD, PhD, Showa University School of Medicine; S. Kawai, MD, PhD, Toho University School of Medicine; A. Kawakami, MD, PhD, Nagasaki University Graduate School of Biomedical Sciences; T. Koike, MD, PhD, Osaka City University Medical School; H. Miyahara, MD, PhD, National Hospital Organization Kyushu Medical Center; T. Miyamoto, MD, Seirei Hamamatsu General Hospital; Y. Munakata, MD, PhD, Munakata Yasuhiko Clinic; A. Murasawa, MD, PhD, Niigata Rheumatic Center; N. Nishimoto, MD, PhD, Osaka Rheumatology Clinic; N. Ogawa, MD, PhD, Hamamatsu University School of Medicine; T. Ojima, MD, PhD, Fukui General Hospital; H. Sano, MD, PhD, Hyogo College of Medicine; K. Shi, MD, PhD, Osaka University Graduate School of Medicine; E. Shono, MD, PhD, Shono Rheumatology Clinic; E. Suematsu, MD, National Hospital Organization Kyushu Medical Center; K.H. Takahashi, MD, PhD, Sapporo Medical University School of Medicine; Y. Tanaka, MD, PhD, University of Occupation and Environmental Health; H. Tsukamoto, MD, PhD, Kyushu University Graduate School of Medical Sciences; A. Nomura, MSc, Chugai Pharmaceutical. Address correspondence to Dr. A. Ogata, Department of Respiratory Medicine, Allergy and Rheumatic Disease, Osaka University Graduate School of Medicine, 2-2, Yamadaoka, Suita, Osaka 565-0871, Japan. E-mail: ogata@imed3.med.osaka-u.ac.jp Accepted for publication January 27, 2015.
Hisaaki Miyahara
From the Department of Respiratory Medicine, Allergy and Rheumatic Disease, Osaka University Graduate School of Medicine and Department of Immunopathology, WPI Immunology Frontier Research Center, Osaka University, Osaka; Department of Rheumatology and Clinical Immunology, Saitama Medical Center, Saitama Medical University, Saitama; Department of Internal Medicine, Division of Endocrinology and Metabolism, Hematology, Rheumatology and Respiratory Medicine, Faculty of Medicine, Kagawa University; Department of Rheumatology, Utazu-Hama Clinic, Kagawa; Department of Hematology and Rheumatology, Tohoku University Hospital, Sendai; Division of Rheumatology, Department of Medicine, Showa University School of Medicine; Division of Rheumatology, Department of Internal Medicine, Toho University School of Medicine, Tokyo; Unit of Translational Medicine, Department of Immunology and Rheumatology, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki; Department of Rheumatosurgery, Osaka City University, Graduate School of Medicine, Osaka; Department of Internal Medicine and Rheumatology, National Hospital Organization Kyushu Medical Center, Fukuoka; Department of Rheumatology, Seirei Hamamatsu General Hospital, Shizuoka; Munakata Yasuhiko Clinic, Miyagi; Department of Rheumatology, Niigata Rheumatic Center, Niigata; Osaka Rheumatology Clinic, Osaka; Third Department of Internal Medicine, Hamamatsu University School of Medicine, Shizuoka; Department of Orthopedic Surgery, Fukui General Hospital, Fukui; Division of Rheumatology, Department of Internal Medicine, Hyogo College of Medicine, Hyogo; Department of Orthopedic Surgery, Osaka University Graduate School of Medicine, Osaka; Shono Rheumatology Clinic, Fukuoka; First Department of Internal Medicine, Sapporo Medical University School of Medicine, Hokkaido; The First Department of Internal Medicine, School of Medicine, University of Occupational and Environmental Health, Fukuoka; Department of Medicine and Biosystemic Science, Kyushu University Graduate School of Medical Sciences, Fukuoka; Chugai Pharmaceutical Co. Ltd., Tokyo, Japan. Funded by Chugai Pharmaceutical Co. Ltd. Support for third-party writing assistance for this manuscript, provided by Denise Kenski, PhD, of Health Interactions, was supported by Genentech Inc. A. Ogata has received consulting fees, speaking fees, and/or honoraria from Chugai Pharmaceutical. N. Nishimoto has received consulting fees, speaking fees, and patent or license-related income from Chugai Pharmaceutical. Y. Tanaka has received speaking fees from Chugai Pharmaceutical. A. Nomura is employed by Chugai Pharmaceutical. A. Ogata, MD, PhD, Osaka University Graduate School of Medicine and Osaka University; K. Amano, MD, PhD, Saitama Medical Centre, Saitama Medical University; H. Dobashi, MD, PhD, Kagawa University; M. Inoo, MD, PhD, Utazu-Hama Clinic; T. Ishii, MD, PhD, Tohoku University Hospital; T. Kasama, MD, PhD, Showa University School of Medicine; S. Kawai, MD, PhD, Toho University School of Medicine; A. Kawakami, MD, PhD, Nagasaki University Graduate School of Biomedical Sciences; T. Koike, MD, PhD, Osaka City University Medical School; H. Miyahara, MD, PhD, National Hospital Organization Kyushu Medical Center; T. Miyamoto, MD, Seirei Hamamatsu General Hospital; Y. Munakata, MD, PhD, Munakata Yasuhiko Clinic; A. Murasawa, MD, PhD, Niigata Rheumatic Center; N. Nishimoto, MD, PhD, Osaka Rheumatology Clinic; N. Ogawa, MD, PhD, Hamamatsu University School of Medicine; T. Ojima, MD, PhD, Fukui General Hospital; H. Sano, MD, PhD, Hyogo College of Medicine; K. Shi, MD, PhD, Osaka University Graduate School of Medicine; E. Shono, MD, PhD, Shono Rheumatology Clinic; E. Suematsu, MD, National Hospital Organization Kyushu Medical Center; K.H. Takahashi, MD, PhD, Sapporo Medical University School of Medicine; Y. Tanaka, MD, PhD, University of Occupation and Environmental Health; H. Tsukamoto, MD, PhD, Kyushu University Graduate School of Medical Sciences; A. Nomura, MSc, Chugai Pharmaceutical. Address correspondence to Dr. A. Ogata, Department of Respiratory Medicine, Allergy and Rheumatic Disease, Osaka University Graduate School of Medicine, 2-2, Yamadaoka, Suita, Osaka 565-0871, Japan. E-mail: ogata@imed3.med.osaka-u.ac.jp Accepted for publication January 27, 2015.
Toshiaki Miyamoto
From the Department of Respiratory Medicine, Allergy and Rheumatic Disease, Osaka University Graduate School of Medicine and Department of Immunopathology, WPI Immunology Frontier Research Center, Osaka University, Osaka; Department of Rheumatology and Clinical Immunology, Saitama Medical Center, Saitama Medical University, Saitama; Department of Internal Medicine, Division of Endocrinology and Metabolism, Hematology, Rheumatology and Respiratory Medicine, Faculty of Medicine, Kagawa University; Department of Rheumatology, Utazu-Hama Clinic, Kagawa; Department of Hematology and Rheumatology, Tohoku University Hospital, Sendai; Division of Rheumatology, Department of Medicine, Showa University School of Medicine; Division of Rheumatology, Department of Internal Medicine, Toho University School of Medicine, Tokyo; Unit of Translational Medicine, Department of Immunology and Rheumatology, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki; Department of Rheumatosurgery, Osaka City University, Graduate School of Medicine, Osaka; Department of Internal Medicine and Rheumatology, National Hospital Organization Kyushu Medical Center, Fukuoka; Department of Rheumatology, Seirei Hamamatsu General Hospital, Shizuoka; Munakata Yasuhiko Clinic, Miyagi; Department of Rheumatology, Niigata Rheumatic Center, Niigata; Osaka Rheumatology Clinic, Osaka; Third Department of Internal Medicine, Hamamatsu University School of Medicine, Shizuoka; Department of Orthopedic Surgery, Fukui General Hospital, Fukui; Division of Rheumatology, Department of Internal Medicine, Hyogo College of Medicine, Hyogo; Department of Orthopedic Surgery, Osaka University Graduate School of Medicine, Osaka; Shono Rheumatology Clinic, Fukuoka; First Department of Internal Medicine, Sapporo Medical University School of Medicine, Hokkaido; The First Department of Internal Medicine, School of Medicine, University of Occupational and Environmental Health, Fukuoka; Department of Medicine and Biosystemic Science, Kyushu University Graduate School of Medical Sciences, Fukuoka; Chugai Pharmaceutical Co. Ltd., Tokyo, Japan. Funded by Chugai Pharmaceutical Co. Ltd. Support for third-party writing assistance for this manuscript, provided by Denise Kenski, PhD, of Health Interactions, was supported by Genentech Inc. A. Ogata has received consulting fees, speaking fees, and/or honoraria from Chugai Pharmaceutical. N. Nishimoto has received consulting fees, speaking fees, and patent or license-related income from Chugai Pharmaceutical. Y. Tanaka has received speaking fees from Chugai Pharmaceutical. A. Nomura is employed by Chugai Pharmaceutical. A. Ogata, MD, PhD, Osaka University Graduate School of Medicine and Osaka University; K. Amano, MD, PhD, Saitama Medical Centre, Saitama Medical University; H. Dobashi, MD, PhD, Kagawa University; M. Inoo, MD, PhD, Utazu-Hama Clinic; T. Ishii, MD, PhD, Tohoku University Hospital; T. Kasama, MD, PhD, Showa University School of Medicine; S. Kawai, MD, PhD, Toho University School of Medicine; A. Kawakami, MD, PhD, Nagasaki University Graduate School of Biomedical Sciences; T. Koike, MD, PhD, Osaka City University Medical School; H. Miyahara, MD, PhD, National Hospital Organization Kyushu Medical Center; T. Miyamoto, MD, Seirei Hamamatsu General Hospital; Y. Munakata, MD, PhD, Munakata Yasuhiko Clinic; A. Murasawa, MD, PhD, Niigata Rheumatic Center; N. Nishimoto, MD, PhD, Osaka Rheumatology Clinic; N. Ogawa, MD, PhD, Hamamatsu University School of Medicine; T. Ojima, MD, PhD, Fukui General Hospital; H. Sano, MD, PhD, Hyogo College of Medicine; K. Shi, MD, PhD, Osaka University Graduate School of Medicine; E. Shono, MD, PhD, Shono Rheumatology Clinic; E. Suematsu, MD, National Hospital Organization Kyushu Medical Center; K.H. Takahashi, MD, PhD, Sapporo Medical University School of Medicine; Y. Tanaka, MD, PhD, University of Occupation and Environmental Health; H. Tsukamoto, MD, PhD, Kyushu University Graduate School of Medical Sciences; A. Nomura, MSc, Chugai Pharmaceutical. Address correspondence to Dr. A. Ogata, Department of Respiratory Medicine, Allergy and Rheumatic Disease, Osaka University Graduate School of Medicine, 2-2, Yamadaoka, Suita, Osaka 565-0871, Japan. E-mail: ogata@imed3.med.osaka-u.ac.jp Accepted for publication January 27, 2015.
Yasuhiko Munakata
From the Department of Respiratory Medicine, Allergy and Rheumatic Disease, Osaka University Graduate School of Medicine and Department of Immunopathology, WPI Immunology Frontier Research Center, Osaka University, Osaka; Department of Rheumatology and Clinical Immunology, Saitama Medical Center, Saitama Medical University, Saitama; Department of Internal Medicine, Division of Endocrinology and Metabolism, Hematology, Rheumatology and Respiratory Medicine, Faculty of Medicine, Kagawa University; Department of Rheumatology, Utazu-Hama Clinic, Kagawa; Department of Hematology and Rheumatology, Tohoku University Hospital, Sendai; Division of Rheumatology, Department of Medicine, Showa University School of Medicine; Division of Rheumatology, Department of Internal Medicine, Toho University School of Medicine, Tokyo; Unit of Translational Medicine, Department of Immunology and Rheumatology, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki; Department of Rheumatosurgery, Osaka City University, Graduate School of Medicine, Osaka; Department of Internal Medicine and Rheumatology, National Hospital Organization Kyushu Medical Center, Fukuoka; Department of Rheumatology, Seirei Hamamatsu General Hospital, Shizuoka; Munakata Yasuhiko Clinic, Miyagi; Department of Rheumatology, Niigata Rheumatic Center, Niigata; Osaka Rheumatology Clinic, Osaka; Third Department of Internal Medicine, Hamamatsu University School of Medicine, Shizuoka; Department of Orthopedic Surgery, Fukui General Hospital, Fukui; Division of Rheumatology, Department of Internal Medicine, Hyogo College of Medicine, Hyogo; Department of Orthopedic Surgery, Osaka University Graduate School of Medicine, Osaka; Shono Rheumatology Clinic, Fukuoka; First Department of Internal Medicine, Sapporo Medical University School of Medicine, Hokkaido; The First Department of Internal Medicine, School of Medicine, University of Occupational and Environmental Health, Fukuoka; Department of Medicine and Biosystemic Science, Kyushu University Graduate School of Medical Sciences, Fukuoka; Chugai Pharmaceutical Co. Ltd., Tokyo, Japan. Funded by Chugai Pharmaceutical Co. Ltd. Support for third-party writing assistance for this manuscript, provided by Denise Kenski, PhD, of Health Interactions, was supported by Genentech Inc. A. Ogata has received consulting fees, speaking fees, and/or honoraria from Chugai Pharmaceutical. N. Nishimoto has received consulting fees, speaking fees, and patent or license-related income from Chugai Pharmaceutical. Y. Tanaka has received speaking fees from Chugai Pharmaceutical. A. Nomura is employed by Chugai Pharmaceutical. A. Ogata, MD, PhD, Osaka University Graduate School of Medicine and Osaka University; K. Amano, MD, PhD, Saitama Medical Centre, Saitama Medical University; H. Dobashi, MD, PhD, Kagawa University; M. Inoo, MD, PhD, Utazu-Hama Clinic; T. Ishii, MD, PhD, Tohoku University Hospital; T. Kasama, MD, PhD, Showa University School of Medicine; S. Kawai, MD, PhD, Toho University School of Medicine; A. Kawakami, MD, PhD, Nagasaki University Graduate School of Biomedical Sciences; T. Koike, MD, PhD, Osaka City University Medical School; H. Miyahara, MD, PhD, National Hospital Organization Kyushu Medical Center; T. Miyamoto, MD, Seirei Hamamatsu General Hospital; Y. Munakata, MD, PhD, Munakata Yasuhiko Clinic; A. Murasawa, MD, PhD, Niigata Rheumatic Center; N. Nishimoto, MD, PhD, Osaka Rheumatology Clinic; N. Ogawa, MD, PhD, Hamamatsu University School of Medicine; T. Ojima, MD, PhD, Fukui General Hospital; H. Sano, MD, PhD, Hyogo College of Medicine; K. Shi, MD, PhD, Osaka University Graduate School of Medicine; E. Shono, MD, PhD, Shono Rheumatology Clinic; E. Suematsu, MD, National Hospital Organization Kyushu Medical Center; K.H. Takahashi, MD, PhD, Sapporo Medical University School of Medicine; Y. Tanaka, MD, PhD, University of Occupation and Environmental Health; H. Tsukamoto, MD, PhD, Kyushu University Graduate School of Medical Sciences; A. Nomura, MSc, Chugai Pharmaceutical. Address correspondence to Dr. A. Ogata, Department of Respiratory Medicine, Allergy and Rheumatic Disease, Osaka University Graduate School of Medicine, 2-2, Yamadaoka, Suita, Osaka 565-0871, Japan. E-mail: ogata@imed3.med.osaka-u.ac.jp Accepted for publication January 27, 2015.
Akira Murasawa
From the Department of Respiratory Medicine, Allergy and Rheumatic Disease, Osaka University Graduate School of Medicine and Department of Immunopathology, WPI Immunology Frontier Research Center, Osaka University, Osaka; Department of Rheumatology and Clinical Immunology, Saitama Medical Center, Saitama Medical University, Saitama; Department of Internal Medicine, Division of Endocrinology and Metabolism, Hematology, Rheumatology and Respiratory Medicine, Faculty of Medicine, Kagawa University; Department of Rheumatology, Utazu-Hama Clinic, Kagawa; Department of Hematology and Rheumatology, Tohoku University Hospital, Sendai; Division of Rheumatology, Department of Medicine, Showa University School of Medicine; Division of Rheumatology, Department of Internal Medicine, Toho University School of Medicine, Tokyo; Unit of Translational Medicine, Department of Immunology and Rheumatology, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki; Department of Rheumatosurgery, Osaka City University, Graduate School of Medicine, Osaka; Department of Internal Medicine and Rheumatology, National Hospital Organization Kyushu Medical Center, Fukuoka; Department of Rheumatology, Seirei Hamamatsu General Hospital, Shizuoka; Munakata Yasuhiko Clinic, Miyagi; Department of Rheumatology, Niigata Rheumatic Center, Niigata; Osaka Rheumatology Clinic, Osaka; Third Department of Internal Medicine, Hamamatsu University School of Medicine, Shizuoka; Department of Orthopedic Surgery, Fukui General Hospital, Fukui; Division of Rheumatology, Department of Internal Medicine, Hyogo College of Medicine, Hyogo; Department of Orthopedic Surgery, Osaka University Graduate School of Medicine, Osaka; Shono Rheumatology Clinic, Fukuoka; First Department of Internal Medicine, Sapporo Medical University School of Medicine, Hokkaido; The First Department of Internal Medicine, School of Medicine, University of Occupational and Environmental Health, Fukuoka; Department of Medicine and Biosystemic Science, Kyushu University Graduate School of Medical Sciences, Fukuoka; Chugai Pharmaceutical Co. Ltd., Tokyo, Japan. Funded by Chugai Pharmaceutical Co. Ltd. Support for third-party writing assistance for this manuscript, provided by Denise Kenski, PhD, of Health Interactions, was supported by Genentech Inc. A. Ogata has received consulting fees, speaking fees, and/or honoraria from Chugai Pharmaceutical. N. Nishimoto has received consulting fees, speaking fees, and patent or license-related income from Chugai Pharmaceutical. Y. Tanaka has received speaking fees from Chugai Pharmaceutical. A. Nomura is employed by Chugai Pharmaceutical. A. Ogata, MD, PhD, Osaka University Graduate School of Medicine and Osaka University; K. Amano, MD, PhD, Saitama Medical Centre, Saitama Medical University; H. Dobashi, MD, PhD, Kagawa University; M. Inoo, MD, PhD, Utazu-Hama Clinic; T. Ishii, MD, PhD, Tohoku University Hospital; T. Kasama, MD, PhD, Showa University School of Medicine; S. Kawai, MD, PhD, Toho University School of Medicine; A. Kawakami, MD, PhD, Nagasaki University Graduate School of Biomedical Sciences; T. Koike, MD, PhD, Osaka City University Medical School; H. Miyahara, MD, PhD, National Hospital Organization Kyushu Medical Center; T. Miyamoto, MD, Seirei Hamamatsu General Hospital; Y. Munakata, MD, PhD, Munakata Yasuhiko Clinic; A. Murasawa, MD, PhD, Niigata Rheumatic Center; N. Nishimoto, MD, PhD, Osaka Rheumatology Clinic; N. Ogawa, MD, PhD, Hamamatsu University School of Medicine; T. Ojima, MD, PhD, Fukui General Hospital; H. Sano, MD, PhD, Hyogo College of Medicine; K. Shi, MD, PhD, Osaka University Graduate School of Medicine; E. Shono, MD, PhD, Shono Rheumatology Clinic; E. Suematsu, MD, National Hospital Organization Kyushu Medical Center; K.H. Takahashi, MD, PhD, Sapporo Medical University School of Medicine; Y. Tanaka, MD, PhD, University of Occupation and Environmental Health; H. Tsukamoto, MD, PhD, Kyushu University Graduate School of Medical Sciences; A. Nomura, MSc, Chugai Pharmaceutical. Address correspondence to Dr. A. Ogata, Department of Respiratory Medicine, Allergy and Rheumatic Disease, Osaka University Graduate School of Medicine, 2-2, Yamadaoka, Suita, Osaka 565-0871, Japan. E-mail: ogata@imed3.med.osaka-u.ac.jp Accepted for publication January 27, 2015.
Norihiro Nishimoto
From the Department of Respiratory Medicine, Allergy and Rheumatic Disease, Osaka University Graduate School of Medicine and Department of Immunopathology, WPI Immunology Frontier Research Center, Osaka University, Osaka; Department of Rheumatology and Clinical Immunology, Saitama Medical Center, Saitama Medical University, Saitama; Department of Internal Medicine, Division of Endocrinology and Metabolism, Hematology, Rheumatology and Respiratory Medicine, Faculty of Medicine, Kagawa University; Department of Rheumatology, Utazu-Hama Clinic, Kagawa; Department of Hematology and Rheumatology, Tohoku University Hospital, Sendai; Division of Rheumatology, Department of Medicine, Showa University School of Medicine; Division of Rheumatology, Department of Internal Medicine, Toho University School of Medicine, Tokyo; Unit of Translational Medicine, Department of Immunology and Rheumatology, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki; Department of Rheumatosurgery, Osaka City University, Graduate School of Medicine, Osaka; Department of Internal Medicine and Rheumatology, National Hospital Organization Kyushu Medical Center, Fukuoka; Department of Rheumatology, Seirei Hamamatsu General Hospital, Shizuoka; Munakata Yasuhiko Clinic, Miyagi; Department of Rheumatology, Niigata Rheumatic Center, Niigata; Osaka Rheumatology Clinic, Osaka; Third Department of Internal Medicine, Hamamatsu University School of Medicine, Shizuoka; Department of Orthopedic Surgery, Fukui General Hospital, Fukui; Division of Rheumatology, Department of Internal Medicine, Hyogo College of Medicine, Hyogo; Department of Orthopedic Surgery, Osaka University Graduate School of Medicine, Osaka; Shono Rheumatology Clinic, Fukuoka; First Department of Internal Medicine, Sapporo Medical University School of Medicine, Hokkaido; The First Department of Internal Medicine, School of Medicine, University of Occupational and Environmental Health, Fukuoka; Department of Medicine and Biosystemic Science, Kyushu University Graduate School of Medical Sciences, Fukuoka; Chugai Pharmaceutical Co. Ltd., Tokyo, Japan. Funded by Chugai Pharmaceutical Co. Ltd. Support for third-party writing assistance for this manuscript, provided by Denise Kenski, PhD, of Health Interactions, was supported by Genentech Inc. A. Ogata has received consulting fees, speaking fees, and/or honoraria from Chugai Pharmaceutical. N. Nishimoto has received consulting fees, speaking fees, and patent or license-related income from Chugai Pharmaceutical. Y. Tanaka has received speaking fees from Chugai Pharmaceutical. A. Nomura is employed by Chugai Pharmaceutical. A. Ogata, MD, PhD, Osaka University Graduate School of Medicine and Osaka University; K. Amano, MD, PhD, Saitama Medical Centre, Saitama Medical University; H. Dobashi, MD, PhD, Kagawa University; M. Inoo, MD, PhD, Utazu-Hama Clinic; T. Ishii, MD, PhD, Tohoku University Hospital; T. Kasama, MD, PhD, Showa University School of Medicine; S. Kawai, MD, PhD, Toho University School of Medicine; A. Kawakami, MD, PhD, Nagasaki University Graduate School of Biomedical Sciences; T. Koike, MD, PhD, Osaka City University Medical School; H. Miyahara, MD, PhD, National Hospital Organization Kyushu Medical Center; T. Miyamoto, MD, Seirei Hamamatsu General Hospital; Y. Munakata, MD, PhD, Munakata Yasuhiko Clinic; A. Murasawa, MD, PhD, Niigata Rheumatic Center; N. Nishimoto, MD, PhD, Osaka Rheumatology Clinic; N. Ogawa, MD, PhD, Hamamatsu University School of Medicine; T. Ojima, MD, PhD, Fukui General Hospital; H. Sano, MD, PhD, Hyogo College of Medicine; K. Shi, MD, PhD, Osaka University Graduate School of Medicine; E. Shono, MD, PhD, Shono Rheumatology Clinic; E. Suematsu, MD, National Hospital Organization Kyushu Medical Center; K.H. Takahashi, MD, PhD, Sapporo Medical University School of Medicine; Y. Tanaka, MD, PhD, University of Occupation and Environmental Health; H. Tsukamoto, MD, PhD, Kyushu University Graduate School of Medical Sciences; A. Nomura, MSc, Chugai Pharmaceutical. Address correspondence to Dr. A. Ogata, Department of Respiratory Medicine, Allergy and Rheumatic Disease, Osaka University Graduate School of Medicine, 2-2, Yamadaoka, Suita, Osaka 565-0871, Japan. E-mail: ogata@imed3.med.osaka-u.ac.jp Accepted for publication January 27, 2015.
Noriyoshi Ogawa
From the Department of Respiratory Medicine, Allergy and Rheumatic Disease, Osaka University Graduate School of Medicine and Department of Immunopathology, WPI Immunology Frontier Research Center, Osaka University, Osaka; Department of Rheumatology and Clinical Immunology, Saitama Medical Center, Saitama Medical University, Saitama; Department of Internal Medicine, Division of Endocrinology and Metabolism, Hematology, Rheumatology and Respiratory Medicine, Faculty of Medicine, Kagawa University; Department of Rheumatology, Utazu-Hama Clinic, Kagawa; Department of Hematology and Rheumatology, Tohoku University Hospital, Sendai; Division of Rheumatology, Department of Medicine, Showa University School of Medicine; Division of Rheumatology, Department of Internal Medicine, Toho University School of Medicine, Tokyo; Unit of Translational Medicine, Department of Immunology and Rheumatology, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki; Department of Rheumatosurgery, Osaka City University, Graduate School of Medicine, Osaka; Department of Internal Medicine and Rheumatology, National Hospital Organization Kyushu Medical Center, Fukuoka; Department of Rheumatology, Seirei Hamamatsu General Hospital, Shizuoka; Munakata Yasuhiko Clinic, Miyagi; Department of Rheumatology, Niigata Rheumatic Center, Niigata; Osaka Rheumatology Clinic, Osaka; Third Department of Internal Medicine, Hamamatsu University School of Medicine, Shizuoka; Department of Orthopedic Surgery, Fukui General Hospital, Fukui; Division of Rheumatology, Department of Internal Medicine, Hyogo College of Medicine, Hyogo; Department of Orthopedic Surgery, Osaka University Graduate School of Medicine, Osaka; Shono Rheumatology Clinic, Fukuoka; First Department of Internal Medicine, Sapporo Medical University School of Medicine, Hokkaido; The First Department of Internal Medicine, School of Medicine, University of Occupational and Environmental Health, Fukuoka; Department of Medicine and Biosystemic Science, Kyushu University Graduate School of Medical Sciences, Fukuoka; Chugai Pharmaceutical Co. Ltd., Tokyo, Japan. Funded by Chugai Pharmaceutical Co. Ltd. Support for third-party writing assistance for this manuscript, provided by Denise Kenski, PhD, of Health Interactions, was supported by Genentech Inc. A. Ogata has received consulting fees, speaking fees, and/or honoraria from Chugai Pharmaceutical. N. Nishimoto has received consulting fees, speaking fees, and patent or license-related income from Chugai Pharmaceutical. Y. Tanaka has received speaking fees from Chugai Pharmaceutical. A. Nomura is employed by Chugai Pharmaceutical. A. Ogata, MD, PhD, Osaka University Graduate School of Medicine and Osaka University; K. Amano, MD, PhD, Saitama Medical Centre, Saitama Medical University; H. Dobashi, MD, PhD, Kagawa University; M. Inoo, MD, PhD, Utazu-Hama Clinic; T. Ishii, MD, PhD, Tohoku University Hospital; T. Kasama, MD, PhD, Showa University School of Medicine; S. Kawai, MD, PhD, Toho University School of Medicine; A. Kawakami, MD, PhD, Nagasaki University Graduate School of Biomedical Sciences; T. Koike, MD, PhD, Osaka City University Medical School; H. Miyahara, MD, PhD, National Hospital Organization Kyushu Medical Center; T. Miyamoto, MD, Seirei Hamamatsu General Hospital; Y. Munakata, MD, PhD, Munakata Yasuhiko Clinic; A. Murasawa, MD, PhD, Niigata Rheumatic Center; N. Nishimoto, MD, PhD, Osaka Rheumatology Clinic; N. Ogawa, MD, PhD, Hamamatsu University School of Medicine; T. Ojima, MD, PhD, Fukui General Hospital; H. Sano, MD, PhD, Hyogo College of Medicine; K. Shi, MD, PhD, Osaka University Graduate School of Medicine; E. Shono, MD, PhD, Shono Rheumatology Clinic; E. Suematsu, MD, National Hospital Organization Kyushu Medical Center; K.H. Takahashi, MD, PhD, Sapporo Medical University School of Medicine; Y. Tanaka, MD, PhD, University of Occupation and Environmental Health; H. Tsukamoto, MD, PhD, Kyushu University Graduate School of Medical Sciences; A. Nomura, MSc, Chugai Pharmaceutical. Address correspondence to Dr. A. Ogata, Department of Respiratory Medicine, Allergy and Rheumatic Disease, Osaka University Graduate School of Medicine, 2-2, Yamadaoka, Suita, Osaka 565-0871, Japan. E-mail: ogata@imed3.med.osaka-u.ac.jp Accepted for publication January 27, 2015.
Tomohiro Ojima
From the Department of Respiratory Medicine, Allergy and Rheumatic Disease, Osaka University Graduate School of Medicine and Department of Immunopathology, WPI Immunology Frontier Research Center, Osaka University, Osaka; Department of Rheumatology and Clinical Immunology, Saitama Medical Center, Saitama Medical University, Saitama; Department of Internal Medicine, Division of Endocrinology and Metabolism, Hematology, Rheumatology and Respiratory Medicine, Faculty of Medicine, Kagawa University; Department of Rheumatology, Utazu-Hama Clinic, Kagawa; Department of Hematology and Rheumatology, Tohoku University Hospital, Sendai; Division of Rheumatology, Department of Medicine, Showa University School of Medicine; Division of Rheumatology, Department of Internal Medicine, Toho University School of Medicine, Tokyo; Unit of Translational Medicine, Department of Immunology and Rheumatology, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki; Department of Rheumatosurgery, Osaka City University, Graduate School of Medicine, Osaka; Department of Internal Medicine and Rheumatology, National Hospital Organization Kyushu Medical Center, Fukuoka; Department of Rheumatology, Seirei Hamamatsu General Hospital, Shizuoka; Munakata Yasuhiko Clinic, Miyagi; Department of Rheumatology, Niigata Rheumatic Center, Niigata; Osaka Rheumatology Clinic, Osaka; Third Department of Internal Medicine, Hamamatsu University School of Medicine, Shizuoka; Department of Orthopedic Surgery, Fukui General Hospital, Fukui; Division of Rheumatology, Department of Internal Medicine, Hyogo College of Medicine, Hyogo; Department of Orthopedic Surgery, Osaka University Graduate School of Medicine, Osaka; Shono Rheumatology Clinic, Fukuoka; First Department of Internal Medicine, Sapporo Medical University School of Medicine, Hokkaido; The First Department of Internal Medicine, School of Medicine, University of Occupational and Environmental Health, Fukuoka; Department of Medicine and Biosystemic Science, Kyushu University Graduate School of Medical Sciences, Fukuoka; Chugai Pharmaceutical Co. Ltd., Tokyo, Japan. Funded by Chugai Pharmaceutical Co. Ltd. Support for third-party writing assistance for this manuscript, provided by Denise Kenski, PhD, of Health Interactions, was supported by Genentech Inc. A. Ogata has received consulting fees, speaking fees, and/or honoraria from Chugai Pharmaceutical. N. Nishimoto has received consulting fees, speaking fees, and patent or license-related income from Chugai Pharmaceutical. Y. Tanaka has received speaking fees from Chugai Pharmaceutical. A. Nomura is employed by Chugai Pharmaceutical. A. Ogata, MD, PhD, Osaka University Graduate School of Medicine and Osaka University; K. Amano, MD, PhD, Saitama Medical Centre, Saitama Medical University; H. Dobashi, MD, PhD, Kagawa University; M. Inoo, MD, PhD, Utazu-Hama Clinic; T. Ishii, MD, PhD, Tohoku University Hospital; T. Kasama, MD, PhD, Showa University School of Medicine; S. Kawai, MD, PhD, Toho University School of Medicine; A. Kawakami, MD, PhD, Nagasaki University Graduate School of Biomedical Sciences; T. Koike, MD, PhD, Osaka City University Medical School; H. Miyahara, MD, PhD, National Hospital Organization Kyushu Medical Center; T. Miyamoto, MD, Seirei Hamamatsu General Hospital; Y. Munakata, MD, PhD, Munakata Yasuhiko Clinic; A. Murasawa, MD, PhD, Niigata Rheumatic Center; N. Nishimoto, MD, PhD, Osaka Rheumatology Clinic; N. Ogawa, MD, PhD, Hamamatsu University School of Medicine; T. Ojima, MD, PhD, Fukui General Hospital; H. Sano, MD, PhD, Hyogo College of Medicine; K. Shi, MD, PhD, Osaka University Graduate School of Medicine; E. Shono, MD, PhD, Shono Rheumatology Clinic; E. Suematsu, MD, National Hospital Organization Kyushu Medical Center; K.H. Takahashi, MD, PhD, Sapporo Medical University School of Medicine; Y. Tanaka, MD, PhD, University of Occupation and Environmental Health; H. Tsukamoto, MD, PhD, Kyushu University Graduate School of Medical Sciences; A. Nomura, MSc, Chugai Pharmaceutical. Address correspondence to Dr. A. Ogata, Department of Respiratory Medicine, Allergy and Rheumatic Disease, Osaka University Graduate School of Medicine, 2-2, Yamadaoka, Suita, Osaka 565-0871, Japan. E-mail: ogata@imed3.med.osaka-u.ac.jp Accepted for publication January 27, 2015.
Hajime Sano
From the Department of Respiratory Medicine, Allergy and Rheumatic Disease, Osaka University Graduate School of Medicine and Department of Immunopathology, WPI Immunology Frontier Research Center, Osaka University, Osaka; Department of Rheumatology and Clinical Immunology, Saitama Medical Center, Saitama Medical University, Saitama; Department of Internal Medicine, Division of Endocrinology and Metabolism, Hematology, Rheumatology and Respiratory Medicine, Faculty of Medicine, Kagawa University; Department of Rheumatology, Utazu-Hama Clinic, Kagawa; Department of Hematology and Rheumatology, Tohoku University Hospital, Sendai; Division of Rheumatology, Department of Medicine, Showa University School of Medicine; Division of Rheumatology, Department of Internal Medicine, Toho University School of Medicine, Tokyo; Unit of Translational Medicine, Department of Immunology and Rheumatology, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki; Department of Rheumatosurgery, Osaka City University, Graduate School of Medicine, Osaka; Department of Internal Medicine and Rheumatology, National Hospital Organization Kyushu Medical Center, Fukuoka; Department of Rheumatology, Seirei Hamamatsu General Hospital, Shizuoka; Munakata Yasuhiko Clinic, Miyagi; Department of Rheumatology, Niigata Rheumatic Center, Niigata; Osaka Rheumatology Clinic, Osaka; Third Department of Internal Medicine, Hamamatsu University School of Medicine, Shizuoka; Department of Orthopedic Surgery, Fukui General Hospital, Fukui; Division of Rheumatology, Department of Internal Medicine, Hyogo College of Medicine, Hyogo; Department of Orthopedic Surgery, Osaka University Graduate School of Medicine, Osaka; Shono Rheumatology Clinic, Fukuoka; First Department of Internal Medicine, Sapporo Medical University School of Medicine, Hokkaido; The First Department of Internal Medicine, School of Medicine, University of Occupational and Environmental Health, Fukuoka; Department of Medicine and Biosystemic Science, Kyushu University Graduate School of Medical Sciences, Fukuoka; Chugai Pharmaceutical Co. Ltd., Tokyo, Japan. Funded by Chugai Pharmaceutical Co. Ltd. Support for third-party writing assistance for this manuscript, provided by Denise Kenski, PhD, of Health Interactions, was supported by Genentech Inc. A. Ogata has received consulting fees, speaking fees, and/or honoraria from Chugai Pharmaceutical. N. Nishimoto has received consulting fees, speaking fees, and patent or license-related income from Chugai Pharmaceutical. Y. Tanaka has received speaking fees from Chugai Pharmaceutical. A. Nomura is employed by Chugai Pharmaceutical. A. Ogata, MD, PhD, Osaka University Graduate School of Medicine and Osaka University; K. Amano, MD, PhD, Saitama Medical Centre, Saitama Medical University; H. Dobashi, MD, PhD, Kagawa University; M. Inoo, MD, PhD, Utazu-Hama Clinic; T. Ishii, MD, PhD, Tohoku University Hospital; T. Kasama, MD, PhD, Showa University School of Medicine; S. Kawai, MD, PhD, Toho University School of Medicine; A. Kawakami, MD, PhD, Nagasaki University Graduate School of Biomedical Sciences; T. Koike, MD, PhD, Osaka City University Medical School; H. Miyahara, MD, PhD, National Hospital Organization Kyushu Medical Center; T. Miyamoto, MD, Seirei Hamamatsu General Hospital; Y. Munakata, MD, PhD, Munakata Yasuhiko Clinic; A. Murasawa, MD, PhD, Niigata Rheumatic Center; N. Nishimoto, MD, PhD, Osaka Rheumatology Clinic; N. Ogawa, MD, PhD, Hamamatsu University School of Medicine; T. Ojima, MD, PhD, Fukui General Hospital; H. Sano, MD, PhD, Hyogo College of Medicine; K. Shi, MD, PhD, Osaka University Graduate School of Medicine; E. Shono, MD, PhD, Shono Rheumatology Clinic; E. Suematsu, MD, National Hospital Organization Kyushu Medical Center; K.H. Takahashi, MD, PhD, Sapporo Medical University School of Medicine; Y. Tanaka, MD, PhD, University of Occupation and Environmental Health; H. Tsukamoto, MD, PhD, Kyushu University Graduate School of Medical Sciences; A. Nomura, MSc, Chugai Pharmaceutical. Address correspondence to Dr. A. Ogata, Department of Respiratory Medicine, Allergy and Rheumatic Disease, Osaka University Graduate School of Medicine, 2-2, Yamadaoka, Suita, Osaka 565-0871, Japan. E-mail: ogata@imed3.med.osaka-u.ac.jp Accepted for publication January 27, 2015.
Kenrin Shi
From the Department of Respiratory Medicine, Allergy and Rheumatic Disease, Osaka University Graduate School of Medicine and Department of Immunopathology, WPI Immunology Frontier Research Center, Osaka University, Osaka; Department of Rheumatology and Clinical Immunology, Saitama Medical Center, Saitama Medical University, Saitama; Department of Internal Medicine, Division of Endocrinology and Metabolism, Hematology, Rheumatology and Respiratory Medicine, Faculty of Medicine, Kagawa University; Department of Rheumatology, Utazu-Hama Clinic, Kagawa; Department of Hematology and Rheumatology, Tohoku University Hospital, Sendai; Division of Rheumatology, Department of Medicine, Showa University School of Medicine; Division of Rheumatology, Department of Internal Medicine, Toho University School of Medicine, Tokyo; Unit of Translational Medicine, Department of Immunology and Rheumatology, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki; Department of Rheumatosurgery, Osaka City University, Graduate School of Medicine, Osaka; Department of Internal Medicine and Rheumatology, National Hospital Organization Kyushu Medical Center, Fukuoka; Department of Rheumatology, Seirei Hamamatsu General Hospital, Shizuoka; Munakata Yasuhiko Clinic, Miyagi; Department of Rheumatology, Niigata Rheumatic Center, Niigata; Osaka Rheumatology Clinic, Osaka; Third Department of Internal Medicine, Hamamatsu University School of Medicine, Shizuoka; Department of Orthopedic Surgery, Fukui General Hospital, Fukui; Division of Rheumatology, Department of Internal Medicine, Hyogo College of Medicine, Hyogo; Department of Orthopedic Surgery, Osaka University Graduate School of Medicine, Osaka; Shono Rheumatology Clinic, Fukuoka; First Department of Internal Medicine, Sapporo Medical University School of Medicine, Hokkaido; The First Department of Internal Medicine, School of Medicine, University of Occupational and Environmental Health, Fukuoka; Department of Medicine and Biosystemic Science, Kyushu University Graduate School of Medical Sciences, Fukuoka; Chugai Pharmaceutical Co. Ltd., Tokyo, Japan. Funded by Chugai Pharmaceutical Co. Ltd. Support for third-party writing assistance for this manuscript, provided by Denise Kenski, PhD, of Health Interactions, was supported by Genentech Inc. A. Ogata has received consulting fees, speaking fees, and/or honoraria from Chugai Pharmaceutical. N. Nishimoto has received consulting fees, speaking fees, and patent or license-related income from Chugai Pharmaceutical. Y. Tanaka has received speaking fees from Chugai Pharmaceutical. A. Nomura is employed by Chugai Pharmaceutical. A. Ogata, MD, PhD, Osaka University Graduate School of Medicine and Osaka University; K. Amano, MD, PhD, Saitama Medical Centre, Saitama Medical University; H. Dobashi, MD, PhD, Kagawa University; M. Inoo, MD, PhD, Utazu-Hama Clinic; T. Ishii, MD, PhD, Tohoku University Hospital; T. Kasama, MD, PhD, Showa University School of Medicine; S. Kawai, MD, PhD, Toho University School of Medicine; A. Kawakami, MD, PhD, Nagasaki University Graduate School of Biomedical Sciences; T. Koike, MD, PhD, Osaka City University Medical School; H. Miyahara, MD, PhD, National Hospital Organization Kyushu Medical Center; T. Miyamoto, MD, Seirei Hamamatsu General Hospital; Y. Munakata, MD, PhD, Munakata Yasuhiko Clinic; A. Murasawa, MD, PhD, Niigata Rheumatic Center; N. Nishimoto, MD, PhD, Osaka Rheumatology Clinic; N. Ogawa, MD, PhD, Hamamatsu University School of Medicine; T. Ojima, MD, PhD, Fukui General Hospital; H. Sano, MD, PhD, Hyogo College of Medicine; K. Shi, MD, PhD, Osaka University Graduate School of Medicine; E. Shono, MD, PhD, Shono Rheumatology Clinic; E. Suematsu, MD, National Hospital Organization Kyushu Medical Center; K.H. Takahashi, MD, PhD, Sapporo Medical University School of Medicine; Y. Tanaka, MD, PhD, University of Occupation and Environmental Health; H. Tsukamoto, MD, PhD, Kyushu University Graduate School of Medical Sciences; A. Nomura, MSc, Chugai Pharmaceutical. Address correspondence to Dr. A. Ogata, Department of Respiratory Medicine, Allergy and Rheumatic Disease, Osaka University Graduate School of Medicine, 2-2, Yamadaoka, Suita, Osaka 565-0871, Japan. E-mail: ogata@imed3.med.osaka-u.ac.jp Accepted for publication January 27, 2015.
Eisuke Shono
From the Department of Respiratory Medicine, Allergy and Rheumatic Disease, Osaka University Graduate School of Medicine and Department of Immunopathology, WPI Immunology Frontier Research Center, Osaka University, Osaka; Department of Rheumatology and Clinical Immunology, Saitama Medical Center, Saitama Medical University, Saitama; Department of Internal Medicine, Division of Endocrinology and Metabolism, Hematology, Rheumatology and Respiratory Medicine, Faculty of Medicine, Kagawa University; Department of Rheumatology, Utazu-Hama Clinic, Kagawa; Department of Hematology and Rheumatology, Tohoku University Hospital, Sendai; Division of Rheumatology, Department of Medicine, Showa University School of Medicine; Division of Rheumatology, Department of Internal Medicine, Toho University School of Medicine, Tokyo; Unit of Translational Medicine, Department of Immunology and Rheumatology, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki; Department of Rheumatosurgery, Osaka City University, Graduate School of Medicine, Osaka; Department of Internal Medicine and Rheumatology, National Hospital Organization Kyushu Medical Center, Fukuoka; Department of Rheumatology, Seirei Hamamatsu General Hospital, Shizuoka; Munakata Yasuhiko Clinic, Miyagi; Department of Rheumatology, Niigata Rheumatic Center, Niigata; Osaka Rheumatology Clinic, Osaka; Third Department of Internal Medicine, Hamamatsu University School of Medicine, Shizuoka; Department of Orthopedic Surgery, Fukui General Hospital, Fukui; Division of Rheumatology, Department of Internal Medicine, Hyogo College of Medicine, Hyogo; Department of Orthopedic Surgery, Osaka University Graduate School of Medicine, Osaka; Shono Rheumatology Clinic, Fukuoka; First Department of Internal Medicine, Sapporo Medical University School of Medicine, Hokkaido; The First Department of Internal Medicine, School of Medicine, University of Occupational and Environmental Health, Fukuoka; Department of Medicine and Biosystemic Science, Kyushu University Graduate School of Medical Sciences, Fukuoka; Chugai Pharmaceutical Co. Ltd., Tokyo, Japan. Funded by Chugai Pharmaceutical Co. Ltd. Support for third-party writing assistance for this manuscript, provided by Denise Kenski, PhD, of Health Interactions, was supported by Genentech Inc. A. Ogata has received consulting fees, speaking fees, and/or honoraria from Chugai Pharmaceutical. N. Nishimoto has received consulting fees, speaking fees, and patent or license-related income from Chugai Pharmaceutical. Y. Tanaka has received speaking fees from Chugai Pharmaceutical. A. Nomura is employed by Chugai Pharmaceutical. A. Ogata, MD, PhD, Osaka University Graduate School of Medicine and Osaka University; K. Amano, MD, PhD, Saitama Medical Centre, Saitama Medical University; H. Dobashi, MD, PhD, Kagawa University; M. Inoo, MD, PhD, Utazu-Hama Clinic; T. Ishii, MD, PhD, Tohoku University Hospital; T. Kasama, MD, PhD, Showa University School of Medicine; S. Kawai, MD, PhD, Toho University School of Medicine; A. Kawakami, MD, PhD, Nagasaki University Graduate School of Biomedical Sciences; T. Koike, MD, PhD, Osaka City University Medical School; H. Miyahara, MD, PhD, National Hospital Organization Kyushu Medical Center; T. Miyamoto, MD, Seirei Hamamatsu General Hospital; Y. Munakata, MD, PhD, Munakata Yasuhiko Clinic; A. Murasawa, MD, PhD, Niigata Rheumatic Center; N. Nishimoto, MD, PhD, Osaka Rheumatology Clinic; N. Ogawa, MD, PhD, Hamamatsu University School of Medicine; T. Ojima, MD, PhD, Fukui General Hospital; H. Sano, MD, PhD, Hyogo College of Medicine; K. Shi, MD, PhD, Osaka University Graduate School of Medicine; E. Shono, MD, PhD, Shono Rheumatology Clinic; E. Suematsu, MD, National Hospital Organization Kyushu Medical Center; K.H. Takahashi, MD, PhD, Sapporo Medical University School of Medicine; Y. Tanaka, MD, PhD, University of Occupation and Environmental Health; H. Tsukamoto, MD, PhD, Kyushu University Graduate School of Medical Sciences; A. Nomura, MSc, Chugai Pharmaceutical. Address correspondence to Dr. A. Ogata, Department of Respiratory Medicine, Allergy and Rheumatic Disease, Osaka University Graduate School of Medicine, 2-2, Yamadaoka, Suita, Osaka 565-0871, Japan. E-mail: ogata@imed3.med.osaka-u.ac.jp Accepted for publication January 27, 2015.
Eiichi Suematsu
From the Department of Respiratory Medicine, Allergy and Rheumatic Disease, Osaka University Graduate School of Medicine and Department of Immunopathology, WPI Immunology Frontier Research Center, Osaka University, Osaka; Department of Rheumatology and Clinical Immunology, Saitama Medical Center, Saitama Medical University, Saitama; Department of Internal Medicine, Division of Endocrinology and Metabolism, Hematology, Rheumatology and Respiratory Medicine, Faculty of Medicine, Kagawa University; Department of Rheumatology, Utazu-Hama Clinic, Kagawa; Department of Hematology and Rheumatology, Tohoku University Hospital, Sendai; Division of Rheumatology, Department of Medicine, Showa University School of Medicine; Division of Rheumatology, Department of Internal Medicine, Toho University School of Medicine, Tokyo; Unit of Translational Medicine, Department of Immunology and Rheumatology, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki; Department of Rheumatosurgery, Osaka City University, Graduate School of Medicine, Osaka; Department of Internal Medicine and Rheumatology, National Hospital Organization Kyushu Medical Center, Fukuoka; Department of Rheumatology, Seirei Hamamatsu General Hospital, Shizuoka; Munakata Yasuhiko Clinic, Miyagi; Department of Rheumatology, Niigata Rheumatic Center, Niigata; Osaka Rheumatology Clinic, Osaka; Third Department of Internal Medicine, Hamamatsu University School of Medicine, Shizuoka; Department of Orthopedic Surgery, Fukui General Hospital, Fukui; Division of Rheumatology, Department of Internal Medicine, Hyogo College of Medicine, Hyogo; Department of Orthopedic Surgery, Osaka University Graduate School of Medicine, Osaka; Shono Rheumatology Clinic, Fukuoka; First Department of Internal Medicine, Sapporo Medical University School of Medicine, Hokkaido; The First Department of Internal Medicine, School of Medicine, University of Occupational and Environmental Health, Fukuoka; Department of Medicine and Biosystemic Science, Kyushu University Graduate School of Medical Sciences, Fukuoka; Chugai Pharmaceutical Co. Ltd., Tokyo, Japan. Funded by Chugai Pharmaceutical Co. Ltd. Support for third-party writing assistance for this manuscript, provided by Denise Kenski, PhD, of Health Interactions, was supported by Genentech Inc. A. Ogata has received consulting fees, speaking fees, and/or honoraria from Chugai Pharmaceutical. N. Nishimoto has received consulting fees, speaking fees, and patent or license-related income from Chugai Pharmaceutical. Y. Tanaka has received speaking fees from Chugai Pharmaceutical. A. Nomura is employed by Chugai Pharmaceutical. A. Ogata, MD, PhD, Osaka University Graduate School of Medicine and Osaka University; K. Amano, MD, PhD, Saitama Medical Centre, Saitama Medical University; H. Dobashi, MD, PhD, Kagawa University; M. Inoo, MD, PhD, Utazu-Hama Clinic; T. Ishii, MD, PhD, Tohoku University Hospital; T. Kasama, MD, PhD, Showa University School of Medicine; S. Kawai, MD, PhD, Toho University School of Medicine; A. Kawakami, MD, PhD, Nagasaki University Graduate School of Biomedical Sciences; T. Koike, MD, PhD, Osaka City University Medical School; H. Miyahara, MD, PhD, National Hospital Organization Kyushu Medical Center; T. Miyamoto, MD, Seirei Hamamatsu General Hospital; Y. Munakata, MD, PhD, Munakata Yasuhiko Clinic; A. Murasawa, MD, PhD, Niigata Rheumatic Center; N. Nishimoto, MD, PhD, Osaka Rheumatology Clinic; N. Ogawa, MD, PhD, Hamamatsu University School of Medicine; T. Ojima, MD, PhD, Fukui General Hospital; H. Sano, MD, PhD, Hyogo College of Medicine; K. Shi, MD, PhD, Osaka University Graduate School of Medicine; E. Shono, MD, PhD, Shono Rheumatology Clinic; E. Suematsu, MD, National Hospital Organization Kyushu Medical Center; K.H. Takahashi, MD, PhD, Sapporo Medical University School of Medicine; Y. Tanaka, MD, PhD, University of Occupation and Environmental Health; H. Tsukamoto, MD, PhD, Kyushu University Graduate School of Medical Sciences; A. Nomura, MSc, Chugai Pharmaceutical. Address correspondence to Dr. A. Ogata, Department of Respiratory Medicine, Allergy and Rheumatic Disease, Osaka University Graduate School of Medicine, 2-2, Yamadaoka, Suita, Osaka 565-0871, Japan. E-mail: ogata@imed3.med.osaka-u.ac.jp Accepted for publication January 27, 2015.
Hiroki Takahashi
From the Department of Respiratory Medicine, Allergy and Rheumatic Disease, Osaka University Graduate School of Medicine and Department of Immunopathology, WPI Immunology Frontier Research Center, Osaka University, Osaka; Department of Rheumatology and Clinical Immunology, Saitama Medical Center, Saitama Medical University, Saitama; Department of Internal Medicine, Division of Endocrinology and Metabolism, Hematology, Rheumatology and Respiratory Medicine, Faculty of Medicine, Kagawa University; Department of Rheumatology, Utazu-Hama Clinic, Kagawa; Department of Hematology and Rheumatology, Tohoku University Hospital, Sendai; Division of Rheumatology, Department of Medicine, Showa University School of Medicine; Division of Rheumatology, Department of Internal Medicine, Toho University School of Medicine, Tokyo; Unit of Translational Medicine, Department of Immunology and Rheumatology, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki; Department of Rheumatosurgery, Osaka City University, Graduate School of Medicine, Osaka; Department of Internal Medicine and Rheumatology, National Hospital Organization Kyushu Medical Center, Fukuoka; Department of Rheumatology, Seirei Hamamatsu General Hospital, Shizuoka; Munakata Yasuhiko Clinic, Miyagi; Department of Rheumatology, Niigata Rheumatic Center, Niigata; Osaka Rheumatology Clinic, Osaka; Third Department of Internal Medicine, Hamamatsu University School of Medicine, Shizuoka; Department of Orthopedic Surgery, Fukui General Hospital, Fukui; Division of Rheumatology, Department of Internal Medicine, Hyogo College of Medicine, Hyogo; Department of Orthopedic Surgery, Osaka University Graduate School of Medicine, Osaka; Shono Rheumatology Clinic, Fukuoka; First Department of Internal Medicine, Sapporo Medical University School of Medicine, Hokkaido; The First Department of Internal Medicine, School of Medicine, University of Occupational and Environmental Health, Fukuoka; Department of Medicine and Biosystemic Science, Kyushu University Graduate School of Medical Sciences, Fukuoka; Chugai Pharmaceutical Co. Ltd., Tokyo, Japan. Funded by Chugai Pharmaceutical Co. Ltd. Support for third-party writing assistance for this manuscript, provided by Denise Kenski, PhD, of Health Interactions, was supported by Genentech Inc. A. Ogata has received consulting fees, speaking fees, and/or honoraria from Chugai Pharmaceutical. N. Nishimoto has received consulting fees, speaking fees, and patent or license-related income from Chugai Pharmaceutical. Y. Tanaka has received speaking fees from Chugai Pharmaceutical. A. Nomura is employed by Chugai Pharmaceutical. A. Ogata, MD, PhD, Osaka University Graduate School of Medicine and Osaka University; K. Amano, MD, PhD, Saitama Medical Centre, Saitama Medical University; H. Dobashi, MD, PhD, Kagawa University; M. Inoo, MD, PhD, Utazu-Hama Clinic; T. Ishii, MD, PhD, Tohoku University Hospital; T. Kasama, MD, PhD, Showa University School of Medicine; S. Kawai, MD, PhD, Toho University School of Medicine; A. Kawakami, MD, PhD, Nagasaki University Graduate School of Biomedical Sciences; T. Koike, MD, PhD, Osaka City University Medical School; H. Miyahara, MD, PhD, National Hospital Organization Kyushu Medical Center; T. Miyamoto, MD, Seirei Hamamatsu General Hospital; Y. Munakata, MD, PhD, Munakata Yasuhiko Clinic; A. Murasawa, MD, PhD, Niigata Rheumatic Center; N. Nishimoto, MD, PhD, Osaka Rheumatology Clinic; N. Ogawa, MD, PhD, Hamamatsu University School of Medicine; T. Ojima, MD, PhD, Fukui General Hospital; H. Sano, MD, PhD, Hyogo College of Medicine; K. Shi, MD, PhD, Osaka University Graduate School of Medicine; E. Shono, MD, PhD, Shono Rheumatology Clinic; E. Suematsu, MD, National Hospital Organization Kyushu Medical Center; K.H. Takahashi, MD, PhD, Sapporo Medical University School of Medicine; Y. Tanaka, MD, PhD, University of Occupation and Environmental Health; H. Tsukamoto, MD, PhD, Kyushu University Graduate School of Medical Sciences; A. Nomura, MSc, Chugai Pharmaceutical. Address correspondence to Dr. A. Ogata, Department of Respiratory Medicine, Allergy and Rheumatic Disease, Osaka University Graduate School of Medicine, 2-2, Yamadaoka, Suita, Osaka 565-0871, Japan. E-mail: ogata@imed3.med.osaka-u.ac.jp Accepted for publication January 27, 2015.
Yoshiya Tanaka
From the Department of Respiratory Medicine, Allergy and Rheumatic Disease, Osaka University Graduate School of Medicine and Department of Immunopathology, WPI Immunology Frontier Research Center, Osaka University, Osaka; Department of Rheumatology and Clinical Immunology, Saitama Medical Center, Saitama Medical University, Saitama; Department of Internal Medicine, Division of Endocrinology and Metabolism, Hematology, Rheumatology and Respiratory Medicine, Faculty of Medicine, Kagawa University; Department of Rheumatology, Utazu-Hama Clinic, Kagawa; Department of Hematology and Rheumatology, Tohoku University Hospital, Sendai; Division of Rheumatology, Department of Medicine, Showa University School of Medicine; Division of Rheumatology, Department of Internal Medicine, Toho University School of Medicine, Tokyo; Unit of Translational Medicine, Department of Immunology and Rheumatology, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki; Department of Rheumatosurgery, Osaka City University, Graduate School of Medicine, Osaka; Department of Internal Medicine and Rheumatology, National Hospital Organization Kyushu Medical Center, Fukuoka; Department of Rheumatology, Seirei Hamamatsu General Hospital, Shizuoka; Munakata Yasuhiko Clinic, Miyagi; Department of Rheumatology, Niigata Rheumatic Center, Niigata; Osaka Rheumatology Clinic, Osaka; Third Department of Internal Medicine, Hamamatsu University School of Medicine, Shizuoka; Department of Orthopedic Surgery, Fukui General Hospital, Fukui; Division of Rheumatology, Department of Internal Medicine, Hyogo College of Medicine, Hyogo; Department of Orthopedic Surgery, Osaka University Graduate School of Medicine, Osaka; Shono Rheumatology Clinic, Fukuoka; First Department of Internal Medicine, Sapporo Medical University School of Medicine, Hokkaido; The First Department of Internal Medicine, School of Medicine, University of Occupational and Environmental Health, Fukuoka; Department of Medicine and Biosystemic Science, Kyushu University Graduate School of Medical Sciences, Fukuoka; Chugai Pharmaceutical Co. Ltd., Tokyo, Japan. Funded by Chugai Pharmaceutical Co. Ltd. Support for third-party writing assistance for this manuscript, provided by Denise Kenski, PhD, of Health Interactions, was supported by Genentech Inc. A. Ogata has received consulting fees, speaking fees, and/or honoraria from Chugai Pharmaceutical. N. Nishimoto has received consulting fees, speaking fees, and patent or license-related income from Chugai Pharmaceutical. Y. Tanaka has received speaking fees from Chugai Pharmaceutical. A. Nomura is employed by Chugai Pharmaceutical. A. Ogata, MD, PhD, Osaka University Graduate School of Medicine and Osaka University; K. Amano, MD, PhD, Saitama Medical Centre, Saitama Medical University; H. Dobashi, MD, PhD, Kagawa University; M. Inoo, MD, PhD, Utazu-Hama Clinic; T. Ishii, MD, PhD, Tohoku University Hospital; T. Kasama, MD, PhD, Showa University School of Medicine; S. Kawai, MD, PhD, Toho University School of Medicine; A. Kawakami, MD, PhD, Nagasaki University Graduate School of Biomedical Sciences; T. Koike, MD, PhD, Osaka City University Medical School; H. Miyahara, MD, PhD, National Hospital Organization Kyushu Medical Center; T. Miyamoto, MD, Seirei Hamamatsu General Hospital; Y. Munakata, MD, PhD, Munakata Yasuhiko Clinic; A. Murasawa, MD, PhD, Niigata Rheumatic Center; N. Nishimoto, MD, PhD, Osaka Rheumatology Clinic; N. Ogawa, MD, PhD, Hamamatsu University School of Medicine; T. Ojima, MD, PhD, Fukui General Hospital; H. Sano, MD, PhD, Hyogo College of Medicine; K. Shi, MD, PhD, Osaka University Graduate School of Medicine; E. Shono, MD, PhD, Shono Rheumatology Clinic; E. Suematsu, MD, National Hospital Organization Kyushu Medical Center; K.H. Takahashi, MD, PhD, Sapporo Medical University School of Medicine; Y. Tanaka, MD, PhD, University of Occupation and Environmental Health; H. Tsukamoto, MD, PhD, Kyushu University Graduate School of Medical Sciences; A. Nomura, MSc, Chugai Pharmaceutical. Address correspondence to Dr. A. Ogata, Department of Respiratory Medicine, Allergy and Rheumatic Disease, Osaka University Graduate School of Medicine, 2-2, Yamadaoka, Suita, Osaka 565-0871, Japan. E-mail: ogata@imed3.med.osaka-u.ac.jp Accepted for publication January 27, 2015.
Hiroshi Tsukamoto
From the Department of Respiratory Medicine, Allergy and Rheumatic Disease, Osaka University Graduate School of Medicine and Department of Immunopathology, WPI Immunology Frontier Research Center, Osaka University, Osaka; Department of Rheumatology and Clinical Immunology, Saitama Medical Center, Saitama Medical University, Saitama; Department of Internal Medicine, Division of Endocrinology and Metabolism, Hematology, Rheumatology and Respiratory Medicine, Faculty of Medicine, Kagawa University; Department of Rheumatology, Utazu-Hama Clinic, Kagawa; Department of Hematology and Rheumatology, Tohoku University Hospital, Sendai; Division of Rheumatology, Department of Medicine, Showa University School of Medicine; Division of Rheumatology, Department of Internal Medicine, Toho University School of Medicine, Tokyo; Unit of Translational Medicine, Department of Immunology and Rheumatology, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki; Department of Rheumatosurgery, Osaka City University, Graduate School of Medicine, Osaka; Department of Internal Medicine and Rheumatology, National Hospital Organization Kyushu Medical Center, Fukuoka; Department of Rheumatology, Seirei Hamamatsu General Hospital, Shizuoka; Munakata Yasuhiko Clinic, Miyagi; Department of Rheumatology, Niigata Rheumatic Center, Niigata; Osaka Rheumatology Clinic, Osaka; Third Department of Internal Medicine, Hamamatsu University School of Medicine, Shizuoka; Department of Orthopedic Surgery, Fukui General Hospital, Fukui; Division of Rheumatology, Department of Internal Medicine, Hyogo College of Medicine, Hyogo; Department of Orthopedic Surgery, Osaka University Graduate School of Medicine, Osaka; Shono Rheumatology Clinic, Fukuoka; First Department of Internal Medicine, Sapporo Medical University School of Medicine, Hokkaido; The First Department of Internal Medicine, School of Medicine, University of Occupational and Environmental Health, Fukuoka; Department of Medicine and Biosystemic Science, Kyushu University Graduate School of Medical Sciences, Fukuoka; Chugai Pharmaceutical Co. Ltd., Tokyo, Japan. Funded by Chugai Pharmaceutical Co. Ltd. Support for third-party writing assistance for this manuscript, provided by Denise Kenski, PhD, of Health Interactions, was supported by Genentech Inc. A. Ogata has received consulting fees, speaking fees, and/or honoraria from Chugai Pharmaceutical. N. Nishimoto has received consulting fees, speaking fees, and patent or license-related income from Chugai Pharmaceutical. Y. Tanaka has received speaking fees from Chugai Pharmaceutical. A. Nomura is employed by Chugai Pharmaceutical. A. Ogata, MD, PhD, Osaka University Graduate School of Medicine and Osaka University; K. Amano, MD, PhD, Saitama Medical Centre, Saitama Medical University; H. Dobashi, MD, PhD, Kagawa University; M. Inoo, MD, PhD, Utazu-Hama Clinic; T. Ishii, MD, PhD, Tohoku University Hospital; T. Kasama, MD, PhD, Showa University School of Medicine; S. Kawai, MD, PhD, Toho University School of Medicine; A. Kawakami, MD, PhD, Nagasaki University Graduate School of Biomedical Sciences; T. Koike, MD, PhD, Osaka City University Medical School; H. Miyahara, MD, PhD, National Hospital Organization Kyushu Medical Center; T. Miyamoto, MD, Seirei Hamamatsu General Hospital; Y. Munakata, MD, PhD, Munakata Yasuhiko Clinic; A. Murasawa, MD, PhD, Niigata Rheumatic Center; N. Nishimoto, MD, PhD, Osaka Rheumatology Clinic; N. Ogawa, MD, PhD, Hamamatsu University School of Medicine; T. Ojima, MD, PhD, Fukui General Hospital; H. Sano, MD, PhD, Hyogo College of Medicine; K. Shi, MD, PhD, Osaka University Graduate School of Medicine; E. Shono, MD, PhD, Shono Rheumatology Clinic; E. Suematsu, MD, National Hospital Organization Kyushu Medical Center; K.H. Takahashi, MD, PhD, Sapporo Medical University School of Medicine; Y. Tanaka, MD, PhD, University of Occupation and Environmental Health; H. Tsukamoto, MD, PhD, Kyushu University Graduate School of Medical Sciences; A. Nomura, MSc, Chugai Pharmaceutical. Address correspondence to Dr. A. Ogata, Department of Respiratory Medicine, Allergy and Rheumatic Disease, Osaka University Graduate School of Medicine, 2-2, Yamadaoka, Suita, Osaka 565-0871, Japan. E-mail: ogata@imed3.med.osaka-u.ac.jp Accepted for publication January 27, 2015.
Akira Nomura
From the Department of Respiratory Medicine, Allergy and Rheumatic Disease, Osaka University Graduate School of Medicine and Department of Immunopathology, WPI Immunology Frontier Research Center, Osaka University, Osaka; Department of Rheumatology and Clinical Immunology, Saitama Medical Center, Saitama Medical University, Saitama; Department of Internal Medicine, Division of Endocrinology and Metabolism, Hematology, Rheumatology and Respiratory Medicine, Faculty of Medicine, Kagawa University; Department of Rheumatology, Utazu-Hama Clinic, Kagawa; Department of Hematology and Rheumatology, Tohoku University Hospital, Sendai; Division of Rheumatology, Department of Medicine, Showa University School of Medicine; Division of Rheumatology, Department of Internal Medicine, Toho University School of Medicine, Tokyo; Unit of Translational Medicine, Department of Immunology and Rheumatology, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki; Department of Rheumatosurgery, Osaka City University, Graduate School of Medicine, Osaka; Department of Internal Medicine and Rheumatology, National Hospital Organization Kyushu Medical Center, Fukuoka; Department of Rheumatology, Seirei Hamamatsu General Hospital, Shizuoka; Munakata Yasuhiko Clinic, Miyagi; Department of Rheumatology, Niigata Rheumatic Center, Niigata; Osaka Rheumatology Clinic, Osaka; Third Department of Internal Medicine, Hamamatsu University School of Medicine, Shizuoka; Department of Orthopedic Surgery, Fukui General Hospital, Fukui; Division of Rheumatology, Department of Internal Medicine, Hyogo College of Medicine, Hyogo; Department of Orthopedic Surgery, Osaka University Graduate School of Medicine, Osaka; Shono Rheumatology Clinic, Fukuoka; First Department of Internal Medicine, Sapporo Medical University School of Medicine, Hokkaido; The First Department of Internal Medicine, School of Medicine, University of Occupational and Environmental Health, Fukuoka; Department of Medicine and Biosystemic Science, Kyushu University Graduate School of Medical Sciences, Fukuoka; Chugai Pharmaceutical Co. Ltd., Tokyo, Japan. Funded by Chugai Pharmaceutical Co. Ltd. Support for third-party writing assistance for this manuscript, provided by Denise Kenski, PhD, of Health Interactions, was supported by Genentech Inc. A. Ogata has received consulting fees, speaking fees, and/or honoraria from Chugai Pharmaceutical. N. Nishimoto has received consulting fees, speaking fees, and patent or license-related income from Chugai Pharmaceutical. Y. Tanaka has received speaking fees from Chugai Pharmaceutical. A. Nomura is employed by Chugai Pharmaceutical. A. Ogata, MD, PhD, Osaka University Graduate School of Medicine and Osaka University; K. Amano, MD, PhD, Saitama Medical Centre, Saitama Medical University; H. Dobashi, MD, PhD, Kagawa University; M. Inoo, MD, PhD, Utazu-Hama Clinic; T. Ishii, MD, PhD, Tohoku University Hospital; T. Kasama, MD, PhD, Showa University School of Medicine; S. Kawai, MD, PhD, Toho University School of Medicine; A. Kawakami, MD, PhD, Nagasaki University Graduate School of Biomedical Sciences; T. Koike, MD, PhD, Osaka City University Medical School; H. Miyahara, MD, PhD, National Hospital Organization Kyushu Medical Center; T. Miyamoto, MD, Seirei Hamamatsu General Hospital; Y. Munakata, MD, PhD, Munakata Yasuhiko Clinic; A. Murasawa, MD, PhD, Niigata Rheumatic Center; N. Nishimoto, MD, PhD, Osaka Rheumatology Clinic; N. Ogawa, MD, PhD, Hamamatsu University School of Medicine; T. Ojima, MD, PhD, Fukui General Hospital; H. Sano, MD, PhD, Hyogo College of Medicine; K. Shi, MD, PhD, Osaka University Graduate School of Medicine; E. Shono, MD, PhD, Shono Rheumatology Clinic; E. Suematsu, MD, National Hospital Organization Kyushu Medical Center; K.H. Takahashi, MD, PhD, Sapporo Medical University School of Medicine; Y. Tanaka, MD, PhD, University of Occupation and Environmental Health; H. Tsukamoto, MD, PhD, Kyushu University Graduate School of Medical Sciences; A. Nomura, MSc, Chugai Pharmaceutical. Address correspondence to Dr. A. Ogata, Department of Respiratory Medicine, Allergy and Rheumatic Disease, Osaka University Graduate School of Medicine, 2-2, Yamadaoka, Suita, Osaka 565-0871, Japan. E-mail: ogata@imed3.med.osaka-u.ac.jp Accepted for publication January 27, 2015.
Roles: and the MUSASHI Study Investigators
Article Information
jrheum.140665
PubMed
Published By
Print ISSN
Online ISSN
History
- Published online April 1, 2015.
Article Versions
- You are currently viewing a Latest version of this article (April 1, 2015 - 04:00).
- View the most recent version of this article
Copyright & Usage
© 2015 The Journal of Rheumatology
Author Information
- Atsushi Ogata,
- Koichi Amano,
- Hiroaki Dobashi,
- Masayuki Inoo,
- Tomonori Ishii,
- Tsuyoshi Kasama,
- Shinichi Kawai,
- Atsushi Kawakami,
- Tatsuya Koike,
- Hisaaki Miyahara,
- Toshiaki Miyamoto,
- Yasuhiko Munakata,
- Akira Murasawa,
- Norihiro Nishimoto,
- Noriyoshi Ogawa,
- Tomohiro Ojima,
- Hajime Sano,
- Kenrin Shi,
- Eisuke Shono,
- Eiichi Suematsu,
- Hiroki Takahashi,
- Yoshiya Tanaka,
- Hiroshi Tsukamoto and
- Akira Nomura, and the MUSASHI Study Investigators
- From the Department of Respiratory Medicine, Allergy and Rheumatic Disease, Osaka University Graduate School of Medicine and Department of Immunopathology, WPI Immunology Frontier Research Center, Osaka University, Osaka; Department of Rheumatology and Clinical Immunology, Saitama Medical Center, Saitama Medical University, Saitama; Department of Internal Medicine, Division of Endocrinology and Metabolism, Hematology, Rheumatology and Respiratory Medicine, Faculty of Medicine, Kagawa University; Department of Rheumatology, Utazu-Hama Clinic, Kagawa; Department of Hematology and Rheumatology, Tohoku University Hospital, Sendai; Division of Rheumatology, Department of Medicine, Showa University School of Medicine; Division of Rheumatology, Department of Internal Medicine, Toho University School of Medicine, Tokyo; Unit of Translational Medicine, Department of Immunology and Rheumatology, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki; Department of Rheumatosurgery, Osaka City University, Graduate School of Medicine, Osaka; Department of Internal Medicine and Rheumatology, National Hospital Organization Kyushu Medical Center, Fukuoka; Department of Rheumatology, Seirei Hamamatsu General Hospital, Shizuoka; Munakata Yasuhiko Clinic, Miyagi; Department of Rheumatology, Niigata Rheumatic Center, Niigata; Osaka Rheumatology Clinic, Osaka; Third Department of Internal Medicine, Hamamatsu University School of Medicine, Shizuoka; Department of Orthopedic Surgery, Fukui General Hospital, Fukui; Division of Rheumatology, Department of Internal Medicine, Hyogo College of Medicine, Hyogo; Department of Orthopedic Surgery, Osaka University Graduate School of Medicine, Osaka; Shono Rheumatology Clinic, Fukuoka; First Department of Internal Medicine, Sapporo Medical University School of Medicine, Hokkaido; The First Department of Internal Medicine, School of Medicine, University of Occupational and Environmental Health, Fukuoka; Department of Medicine and Biosystemic Science, Kyushu University Graduate School of Medical Sciences, Fukuoka; Chugai Pharmaceutical Co. Ltd., Tokyo, Japan.
Funded by Chugai Pharmaceutical Co. Ltd. Support for third-party writing assistance for this manuscript, provided by Denise Kenski, PhD, of Health Interactions, was supported by Genentech Inc. A. Ogata has received consulting fees, speaking fees, and/or honoraria from Chugai Pharmaceutical. N. Nishimoto has received consulting fees, speaking fees, and patent or license-related income from Chugai Pharmaceutical.
Y. Tanaka has received speaking fees from Chugai Pharmaceutical. A. Nomura is employed by Chugai Pharmaceutical.
A. Ogata, MD, PhD, Osaka University Graduate School of Medicine and Osaka University; K. Amano, MD, PhD, Saitama Medical Centre, Saitama Medical University; H. Dobashi, MD, PhD, Kagawa University; M. Inoo, MD, PhD, Utazu-Hama Clinic; T. Ishii, MD, PhD, Tohoku University Hospital; T. Kasama, MD, PhD, Showa University School of Medicine; S. Kawai, MD, PhD, Toho University School of Medicine; A. Kawakami, MD, PhD, Nagasaki University Graduate School of Biomedical Sciences; T. Koike, MD, PhD, Osaka City University Medical School; H. Miyahara, MD, PhD, National Hospital Organization Kyushu Medical Center; T. Miyamoto, MD, Seirei Hamamatsu General Hospital; Y. Munakata, MD, PhD, Munakata Yasuhiko Clinic; A. Murasawa, MD, PhD, Niigata Rheumatic Center; N. Nishimoto, MD, PhD, Osaka Rheumatology Clinic; N. Ogawa, MD, PhD, Hamamatsu University School of Medicine; T. Ojima, MD, PhD, Fukui General Hospital; H. Sano, MD, PhD, Hyogo College of Medicine; K. Shi, MD, PhD, Osaka University Graduate School of Medicine; E. Shono, MD, PhD, Shono Rheumatology Clinic; E. Suematsu, MD, National Hospital Organization Kyushu Medical Center; K.H. Takahashi, MD, PhD, Sapporo Medical University School of Medicine; Y. Tanaka, MD, PhD, University of Occupation and Environmental Health; H. Tsukamoto, MD, PhD, Kyushu University Graduate School of Medical Sciences; A. Nomura, MSc, Chugai Pharmaceutical.
Address correspondence to Dr. A. Ogata, Department of Respiratory Medicine, Allergy and Rheumatic Disease, Osaka University Graduate School of Medicine, 2-2, Yamadaoka, Suita, Osaka 565-0871, Japan. E-mail: ogata@imed3.med.osaka-u.ac.jp
Accepted for publication January 27, 2015.
Article usage
Statistics from Altmetric.com
In this issue
The Journal of Rheumatology
Vol. 51, Issue 3
1 Mar 2024
Longterm Safety and Efficacy of Subcutaneous Tocilizumab Monotherapy: Results from the 2-year Open-label Extension of the MUSASHI Study
Atsushi Ogata, Koichi Amano, Hiroaki Dobashi, Masayuki Inoo, Tomonori Ishii, Tsuyoshi Kasama, Shinichi Kawai, Atsushi Kawakami, Tatsuya Koike, Hisaaki Miyahara, Toshiaki Miyamoto, Yasuhiko Munakata, Akira Murasawa, Norihiro Nishimoto, Noriyoshi Ogawa, Tomohiro Ojima, Hajime Sano, Kenrin Shi, Eisuke Shono, Eiichi Suematsu, Hiroki Takahashi, Yoshiya Tanaka, Hiroshi Tsukamoto, Akira Nomura
The Journal of Rheumatology Apr 2015, jrheum.140665; DOI: 10.3899/jrheum.140665
Longterm Safety and Efficacy of Subcutaneous Tocilizumab Monotherapy: Results from the 2-year Open-label Extension of the MUSASHI Study
Atsushi Ogata, Koichi Amano, Hiroaki Dobashi, Masayuki Inoo, Tomonori Ishii, Tsuyoshi Kasama, Shinichi Kawai, Atsushi Kawakami, Tatsuya Koike, Hisaaki Miyahara, Toshiaki Miyamoto, Yasuhiko Munakata, Akira Murasawa, Norihiro Nishimoto, Noriyoshi Ogawa, Tomohiro Ojima, Hajime Sano, Kenrin Shi, Eisuke Shono, Eiichi Suematsu, Hiroki Takahashi, Yoshiya Tanaka, Hiroshi Tsukamoto, Akira Nomura
The Journal of Rheumatology Apr 2015, jrheum.140665; DOI: 10.3899/jrheum.140665