Research ArticleArticle
Relationship Between Blood Plasma and Synovial Fluid Metabolite Concentrations in Patients with Osteoarthritis
Weidong Zhang, Sergei Likhodii, Erfan Aref-Eshghi, Yuhua Zhang, Patricia E. Harper, Edward Randell, Roger Green, Glynn Martin, Andrew Furey, Guang Sun, Proton Rahman and Guangju Zhai
The Journal of Rheumatology March 2015, jrheum.141252; DOI: https://doi.org/10.3899/jrheum.141252
Weidong Zhang
From the Discipline of Genetics, Department of Laboratory Medicine, Department of Surgery, Discipline of Medicine, Faculty of Medicine, Memorial University of Newfoundland (MUN), St. John’s, Newfoundland, Canada; Department of Twin Research and Genetic Epidemiology, King’s College London, London, UK. Supported by the Canadian Institutes of Health Research (CIHR); Newfoundland and Labrador Research and Development Corporation; MUN. EAE is supported by the Dean’s PhD Fellowship, MUN; PEH is supported by the CIHR CGS-Master’s Award. W. Zhang, PhD, Postdoctoral Fellow, Discipline of Genetics; S. Likhodii, PhD, Assistant Professor, Department of Laboratory Medicine; E. Aref-Eshghi, MD, PhD student; Y. Zhang, MSc, Statistician; P.E. Harper, BSC, MSc student, Discipline of Genetics; E. Randell, PhD, Associate Professor, Department of Laboratory Medicine; R. Green, PhD, Professor, Discipline of Genetics; G. Martin, MD, Orthopedic Fellow; A. Furey, MD, Associate Professor, Department of Surgery; G. Sun, PhD, Professor; P. Rahman, MD, Professor, Discipline of Medicine, Faculty of Medicine, MUN; G. Zhai, PhD, Associate Professor, Discipline of Genetics, MUN, and Department of Twin Research and Genetic Epidemiology, King’s College London. Address correspondence to Dr. G. Zhai, Discipline of Genetics, Faculty of Medicine, Memorial University of Newfoundland, St. John’s, Newfoundland A1B 3V6, Canada. E-mail: guangju.zhai@med.mun.ca. Accepted for publication January 14, 2015.
Sergei Likhodii
From the Discipline of Genetics, Department of Laboratory Medicine, Department of Surgery, Discipline of Medicine, Faculty of Medicine, Memorial University of Newfoundland (MUN), St. John’s, Newfoundland, Canada; Department of Twin Research and Genetic Epidemiology, King’s College London, London, UK. Supported by the Canadian Institutes of Health Research (CIHR); Newfoundland and Labrador Research and Development Corporation; MUN. EAE is supported by the Dean’s PhD Fellowship, MUN; PEH is supported by the CIHR CGS-Master’s Award. W. Zhang, PhD, Postdoctoral Fellow, Discipline of Genetics; S. Likhodii, PhD, Assistant Professor, Department of Laboratory Medicine; E. Aref-Eshghi, MD, PhD student; Y. Zhang, MSc, Statistician; P.E. Harper, BSC, MSc student, Discipline of Genetics; E. Randell, PhD, Associate Professor, Department of Laboratory Medicine; R. Green, PhD, Professor, Discipline of Genetics; G. Martin, MD, Orthopedic Fellow; A. Furey, MD, Associate Professor, Department of Surgery; G. Sun, PhD, Professor; P. Rahman, MD, Professor, Discipline of Medicine, Faculty of Medicine, MUN; G. Zhai, PhD, Associate Professor, Discipline of Genetics, MUN, and Department of Twin Research and Genetic Epidemiology, King’s College London. Address correspondence to Dr. G. Zhai, Discipline of Genetics, Faculty of Medicine, Memorial University of Newfoundland, St. John’s, Newfoundland A1B 3V6, Canada. E-mail: guangju.zhai@med.mun.ca. Accepted for publication January 14, 2015.
Erfan Aref-Eshghi
From the Discipline of Genetics, Department of Laboratory Medicine, Department of Surgery, Discipline of Medicine, Faculty of Medicine, Memorial University of Newfoundland (MUN), St. John’s, Newfoundland, Canada; Department of Twin Research and Genetic Epidemiology, King’s College London, London, UK. Supported by the Canadian Institutes of Health Research (CIHR); Newfoundland and Labrador Research and Development Corporation; MUN. EAE is supported by the Dean’s PhD Fellowship, MUN; PEH is supported by the CIHR CGS-Master’s Award. W. Zhang, PhD, Postdoctoral Fellow, Discipline of Genetics; S. Likhodii, PhD, Assistant Professor, Department of Laboratory Medicine; E. Aref-Eshghi, MD, PhD student; Y. Zhang, MSc, Statistician; P.E. Harper, BSC, MSc student, Discipline of Genetics; E. Randell, PhD, Associate Professor, Department of Laboratory Medicine; R. Green, PhD, Professor, Discipline of Genetics; G. Martin, MD, Orthopedic Fellow; A. Furey, MD, Associate Professor, Department of Surgery; G. Sun, PhD, Professor; P. Rahman, MD, Professor, Discipline of Medicine, Faculty of Medicine, MUN; G. Zhai, PhD, Associate Professor, Discipline of Genetics, MUN, and Department of Twin Research and Genetic Epidemiology, King’s College London. Address correspondence to Dr. G. Zhai, Discipline of Genetics, Faculty of Medicine, Memorial University of Newfoundland, St. John’s, Newfoundland A1B 3V6, Canada. E-mail: guangju.zhai@med.mun.ca. Accepted for publication January 14, 2015.
Yuhua Zhang
From the Discipline of Genetics, Department of Laboratory Medicine, Department of Surgery, Discipline of Medicine, Faculty of Medicine, Memorial University of Newfoundland (MUN), St. John’s, Newfoundland, Canada; Department of Twin Research and Genetic Epidemiology, King’s College London, London, UK. Supported by the Canadian Institutes of Health Research (CIHR); Newfoundland and Labrador Research and Development Corporation; MUN. EAE is supported by the Dean’s PhD Fellowship, MUN; PEH is supported by the CIHR CGS-Master’s Award. W. Zhang, PhD, Postdoctoral Fellow, Discipline of Genetics; S. Likhodii, PhD, Assistant Professor, Department of Laboratory Medicine; E. Aref-Eshghi, MD, PhD student; Y. Zhang, MSc, Statistician; P.E. Harper, BSC, MSc student, Discipline of Genetics; E. Randell, PhD, Associate Professor, Department of Laboratory Medicine; R. Green, PhD, Professor, Discipline of Genetics; G. Martin, MD, Orthopedic Fellow; A. Furey, MD, Associate Professor, Department of Surgery; G. Sun, PhD, Professor; P. Rahman, MD, Professor, Discipline of Medicine, Faculty of Medicine, MUN; G. Zhai, PhD, Associate Professor, Discipline of Genetics, MUN, and Department of Twin Research and Genetic Epidemiology, King’s College London. Address correspondence to Dr. G. Zhai, Discipline of Genetics, Faculty of Medicine, Memorial University of Newfoundland, St. John’s, Newfoundland A1B 3V6, Canada. E-mail: guangju.zhai@med.mun.ca. Accepted for publication January 14, 2015.
Patricia E. Harper
From the Discipline of Genetics, Department of Laboratory Medicine, Department of Surgery, Discipline of Medicine, Faculty of Medicine, Memorial University of Newfoundland (MUN), St. John’s, Newfoundland, Canada; Department of Twin Research and Genetic Epidemiology, King’s College London, London, UK. Supported by the Canadian Institutes of Health Research (CIHR); Newfoundland and Labrador Research and Development Corporation; MUN. EAE is supported by the Dean’s PhD Fellowship, MUN; PEH is supported by the CIHR CGS-Master’s Award. W. Zhang, PhD, Postdoctoral Fellow, Discipline of Genetics; S. Likhodii, PhD, Assistant Professor, Department of Laboratory Medicine; E. Aref-Eshghi, MD, PhD student; Y. Zhang, MSc, Statistician; P.E. Harper, BSC, MSc student, Discipline of Genetics; E. Randell, PhD, Associate Professor, Department of Laboratory Medicine; R. Green, PhD, Professor, Discipline of Genetics; G. Martin, MD, Orthopedic Fellow; A. Furey, MD, Associate Professor, Department of Surgery; G. Sun, PhD, Professor; P. Rahman, MD, Professor, Discipline of Medicine, Faculty of Medicine, MUN; G. Zhai, PhD, Associate Professor, Discipline of Genetics, MUN, and Department of Twin Research and Genetic Epidemiology, King’s College London. Address correspondence to Dr. G. Zhai, Discipline of Genetics, Faculty of Medicine, Memorial University of Newfoundland, St. John’s, Newfoundland A1B 3V6, Canada. E-mail: guangju.zhai@med.mun.ca. Accepted for publication January 14, 2015.
Edward Randell
From the Discipline of Genetics, Department of Laboratory Medicine, Department of Surgery, Discipline of Medicine, Faculty of Medicine, Memorial University of Newfoundland (MUN), St. John’s, Newfoundland, Canada; Department of Twin Research and Genetic Epidemiology, King’s College London, London, UK. Supported by the Canadian Institutes of Health Research (CIHR); Newfoundland and Labrador Research and Development Corporation; MUN. EAE is supported by the Dean’s PhD Fellowship, MUN; PEH is supported by the CIHR CGS-Master’s Award. W. Zhang, PhD, Postdoctoral Fellow, Discipline of Genetics; S. Likhodii, PhD, Assistant Professor, Department of Laboratory Medicine; E. Aref-Eshghi, MD, PhD student; Y. Zhang, MSc, Statistician; P.E. Harper, BSC, MSc student, Discipline of Genetics; E. Randell, PhD, Associate Professor, Department of Laboratory Medicine; R. Green, PhD, Professor, Discipline of Genetics; G. Martin, MD, Orthopedic Fellow; A. Furey, MD, Associate Professor, Department of Surgery; G. Sun, PhD, Professor; P. Rahman, MD, Professor, Discipline of Medicine, Faculty of Medicine, MUN; G. Zhai, PhD, Associate Professor, Discipline of Genetics, MUN, and Department of Twin Research and Genetic Epidemiology, King’s College London. Address correspondence to Dr. G. Zhai, Discipline of Genetics, Faculty of Medicine, Memorial University of Newfoundland, St. John’s, Newfoundland A1B 3V6, Canada. E-mail: guangju.zhai@med.mun.ca. Accepted for publication January 14, 2015.
Roger Green
From the Discipline of Genetics, Department of Laboratory Medicine, Department of Surgery, Discipline of Medicine, Faculty of Medicine, Memorial University of Newfoundland (MUN), St. John’s, Newfoundland, Canada; Department of Twin Research and Genetic Epidemiology, King’s College London, London, UK. Supported by the Canadian Institutes of Health Research (CIHR); Newfoundland and Labrador Research and Development Corporation; MUN. EAE is supported by the Dean’s PhD Fellowship, MUN; PEH is supported by the CIHR CGS-Master’s Award. W. Zhang, PhD, Postdoctoral Fellow, Discipline of Genetics; S. Likhodii, PhD, Assistant Professor, Department of Laboratory Medicine; E. Aref-Eshghi, MD, PhD student; Y. Zhang, MSc, Statistician; P.E. Harper, BSC, MSc student, Discipline of Genetics; E. Randell, PhD, Associate Professor, Department of Laboratory Medicine; R. Green, PhD, Professor, Discipline of Genetics; G. Martin, MD, Orthopedic Fellow; A. Furey, MD, Associate Professor, Department of Surgery; G. Sun, PhD, Professor; P. Rahman, MD, Professor, Discipline of Medicine, Faculty of Medicine, MUN; G. Zhai, PhD, Associate Professor, Discipline of Genetics, MUN, and Department of Twin Research and Genetic Epidemiology, King’s College London. Address correspondence to Dr. G. Zhai, Discipline of Genetics, Faculty of Medicine, Memorial University of Newfoundland, St. John’s, Newfoundland A1B 3V6, Canada. E-mail: guangju.zhai@med.mun.ca. Accepted for publication January 14, 2015.
Glynn Martin
From the Discipline of Genetics, Department of Laboratory Medicine, Department of Surgery, Discipline of Medicine, Faculty of Medicine, Memorial University of Newfoundland (MUN), St. John’s, Newfoundland, Canada; Department of Twin Research and Genetic Epidemiology, King’s College London, London, UK. Supported by the Canadian Institutes of Health Research (CIHR); Newfoundland and Labrador Research and Development Corporation; MUN. EAE is supported by the Dean’s PhD Fellowship, MUN; PEH is supported by the CIHR CGS-Master’s Award. W. Zhang, PhD, Postdoctoral Fellow, Discipline of Genetics; S. Likhodii, PhD, Assistant Professor, Department of Laboratory Medicine; E. Aref-Eshghi, MD, PhD student; Y. Zhang, MSc, Statistician; P.E. Harper, BSC, MSc student, Discipline of Genetics; E. Randell, PhD, Associate Professor, Department of Laboratory Medicine; R. Green, PhD, Professor, Discipline of Genetics; G. Martin, MD, Orthopedic Fellow; A. Furey, MD, Associate Professor, Department of Surgery; G. Sun, PhD, Professor; P. Rahman, MD, Professor, Discipline of Medicine, Faculty of Medicine, MUN; G. Zhai, PhD, Associate Professor, Discipline of Genetics, MUN, and Department of Twin Research and Genetic Epidemiology, King’s College London. Address correspondence to Dr. G. Zhai, Discipline of Genetics, Faculty of Medicine, Memorial University of Newfoundland, St. John’s, Newfoundland A1B 3V6, Canada. E-mail: guangju.zhai@med.mun.ca. Accepted for publication January 14, 2015.
Andrew Furey
From the Discipline of Genetics, Department of Laboratory Medicine, Department of Surgery, Discipline of Medicine, Faculty of Medicine, Memorial University of Newfoundland (MUN), St. John’s, Newfoundland, Canada; Department of Twin Research and Genetic Epidemiology, King’s College London, London, UK. Supported by the Canadian Institutes of Health Research (CIHR); Newfoundland and Labrador Research and Development Corporation; MUN. EAE is supported by the Dean’s PhD Fellowship, MUN; PEH is supported by the CIHR CGS-Master’s Award. W. Zhang, PhD, Postdoctoral Fellow, Discipline of Genetics; S. Likhodii, PhD, Assistant Professor, Department of Laboratory Medicine; E. Aref-Eshghi, MD, PhD student; Y. Zhang, MSc, Statistician; P.E. Harper, BSC, MSc student, Discipline of Genetics; E. Randell, PhD, Associate Professor, Department of Laboratory Medicine; R. Green, PhD, Professor, Discipline of Genetics; G. Martin, MD, Orthopedic Fellow; A. Furey, MD, Associate Professor, Department of Surgery; G. Sun, PhD, Professor; P. Rahman, MD, Professor, Discipline of Medicine, Faculty of Medicine, MUN; G. Zhai, PhD, Associate Professor, Discipline of Genetics, MUN, and Department of Twin Research and Genetic Epidemiology, King’s College London. Address correspondence to Dr. G. Zhai, Discipline of Genetics, Faculty of Medicine, Memorial University of Newfoundland, St. John’s, Newfoundland A1B 3V6, Canada. E-mail: guangju.zhai@med.mun.ca. Accepted for publication January 14, 2015.
Guang Sun
From the Discipline of Genetics, Department of Laboratory Medicine, Department of Surgery, Discipline of Medicine, Faculty of Medicine, Memorial University of Newfoundland (MUN), St. John’s, Newfoundland, Canada; Department of Twin Research and Genetic Epidemiology, King’s College London, London, UK. Supported by the Canadian Institutes of Health Research (CIHR); Newfoundland and Labrador Research and Development Corporation; MUN. EAE is supported by the Dean’s PhD Fellowship, MUN; PEH is supported by the CIHR CGS-Master’s Award. W. Zhang, PhD, Postdoctoral Fellow, Discipline of Genetics; S. Likhodii, PhD, Assistant Professor, Department of Laboratory Medicine; E. Aref-Eshghi, MD, PhD student; Y. Zhang, MSc, Statistician; P.E. Harper, BSC, MSc student, Discipline of Genetics; E. Randell, PhD, Associate Professor, Department of Laboratory Medicine; R. Green, PhD, Professor, Discipline of Genetics; G. Martin, MD, Orthopedic Fellow; A. Furey, MD, Associate Professor, Department of Surgery; G. Sun, PhD, Professor; P. Rahman, MD, Professor, Discipline of Medicine, Faculty of Medicine, MUN; G. Zhai, PhD, Associate Professor, Discipline of Genetics, MUN, and Department of Twin Research and Genetic Epidemiology, King’s College London. Address correspondence to Dr. G. Zhai, Discipline of Genetics, Faculty of Medicine, Memorial University of Newfoundland, St. John’s, Newfoundland A1B 3V6, Canada. E-mail: guangju.zhai@med.mun.ca. Accepted for publication January 14, 2015.
Proton Rahman
From the Discipline of Genetics, Department of Laboratory Medicine, Department of Surgery, Discipline of Medicine, Faculty of Medicine, Memorial University of Newfoundland (MUN), St. John’s, Newfoundland, Canada; Department of Twin Research and Genetic Epidemiology, King’s College London, London, UK. Supported by the Canadian Institutes of Health Research (CIHR); Newfoundland and Labrador Research and Development Corporation; MUN. EAE is supported by the Dean’s PhD Fellowship, MUN; PEH is supported by the CIHR CGS-Master’s Award. W. Zhang, PhD, Postdoctoral Fellow, Discipline of Genetics; S. Likhodii, PhD, Assistant Professor, Department of Laboratory Medicine; E. Aref-Eshghi, MD, PhD student; Y. Zhang, MSc, Statistician; P.E. Harper, BSC, MSc student, Discipline of Genetics; E. Randell, PhD, Associate Professor, Department of Laboratory Medicine; R. Green, PhD, Professor, Discipline of Genetics; G. Martin, MD, Orthopedic Fellow; A. Furey, MD, Associate Professor, Department of Surgery; G. Sun, PhD, Professor; P. Rahman, MD, Professor, Discipline of Medicine, Faculty of Medicine, MUN; G. Zhai, PhD, Associate Professor, Discipline of Genetics, MUN, and Department of Twin Research and Genetic Epidemiology, King’s College London. Address correspondence to Dr. G. Zhai, Discipline of Genetics, Faculty of Medicine, Memorial University of Newfoundland, St. John’s, Newfoundland A1B 3V6, Canada. E-mail: guangju.zhai@med.mun.ca. Accepted for publication January 14, 2015.
Guangju Zhai
From the Discipline of Genetics, Department of Laboratory Medicine, Department of Surgery, Discipline of Medicine, Faculty of Medicine, Memorial University of Newfoundland (MUN), St. John’s, Newfoundland, Canada; Department of Twin Research and Genetic Epidemiology, King’s College London, London, UK. Supported by the Canadian Institutes of Health Research (CIHR); Newfoundland and Labrador Research and Development Corporation; MUN. EAE is supported by the Dean’s PhD Fellowship, MUN; PEH is supported by the CIHR CGS-Master’s Award. W. Zhang, PhD, Postdoctoral Fellow, Discipline of Genetics; S. Likhodii, PhD, Assistant Professor, Department of Laboratory Medicine; E. Aref-Eshghi, MD, PhD student; Y. Zhang, MSc, Statistician; P.E. Harper, BSC, MSc student, Discipline of Genetics; E. Randell, PhD, Associate Professor, Department of Laboratory Medicine; R. Green, PhD, Professor, Discipline of Genetics; G. Martin, MD, Orthopedic Fellow; A. Furey, MD, Associate Professor, Department of Surgery; G. Sun, PhD, Professor; P. Rahman, MD, Professor, Discipline of Medicine, Faculty of Medicine, MUN; G. Zhai, PhD, Associate Professor, Discipline of Genetics, MUN, and Department of Twin Research and Genetic Epidemiology, King’s College London. Address correspondence to Dr. G. Zhai, Discipline of Genetics, Faculty of Medicine, Memorial University of Newfoundland, St. John’s, Newfoundland A1B 3V6, Canada. E-mail: guangju.zhai@med.mun.ca. Accepted for publication January 14, 2015.
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In this issue
The Journal of Rheumatology
Vol. 51, Issue 4
1 Apr 2024
Relationship Between Blood Plasma and Synovial Fluid Metabolite Concentrations in Patients with Osteoarthritis
Weidong Zhang, Sergei Likhodii, Erfan Aref-Eshghi, Yuhua Zhang, Patricia E. Harper, Edward Randell, Roger Green, Glynn Martin, Andrew Furey, Guang Sun, Proton Rahman, Guangju Zhai
The Journal of Rheumatology Mar 2015, jrheum.141252; DOI: 10.3899/jrheum.141252
Relationship Between Blood Plasma and Synovial Fluid Metabolite Concentrations in Patients with Osteoarthritis
Weidong Zhang, Sergei Likhodii, Erfan Aref-Eshghi, Yuhua Zhang, Patricia E. Harper, Edward Randell, Roger Green, Glynn Martin, Andrew Furey, Guang Sun, Proton Rahman, Guangju Zhai
The Journal of Rheumatology Mar 2015, jrheum.141252; DOI: 10.3899/jrheum.141252