Research ArticleArticle
Second-to-fourth Digit Ratio in Systemic Lupus Erythematosus
Kentaro Doe, Kazuhisa Nozawa, Takuya Hirai, Hiroshi Tsushima, Eri Hayashi, Kaori Hiruma, Seiichiro Ando, Soichiro Nakano, Takayuki Kon, Hirofumi Amano, Ken Yamaji, Naoto Tamura and Yoshinari Takasaki
The Journal of Rheumatology March 2015, jrheum.140974; DOI: https://doi.org/10.3899/jrheum.140974
Kentaro Doe
From the Department of Internal Medicine and Rheumatology, Juntendo University Faculty of Medicine, Tokyo, Japan. K. Doe, MD, PhD; K. Nozawa, MD, PhD; T. Hirai, MD; H. Tsushima, MD; E. Hayashi, MD; K. Hiruma, MD; S. Ando, MD, PhD; S. Nakano, MD, PhD; T. Kon, MD, PhD; H. Amano, MD, PhD; K. Yamaji, MD, PhD; N. Tamura, MD, PhD; Y. Takasaki, MD, PhD, Professor, Department of Internal Medicine and Rheumatology, Juntendo University Faculty of Medicine. Address correspondence to Dr. K. Doe, Department of Internal Medicine and Rheumatology, Juntendo University Faculty of Medicine, 2-1-1 Hongo, Bunkyo-ku, Tokyo, 113-8421, Japan. E-mail: kdoe@juntendo.ac.jp. Accepted for publication January 9, 2015.
Kazuhisa Nozawa
From the Department of Internal Medicine and Rheumatology, Juntendo University Faculty of Medicine, Tokyo, Japan. K. Doe, MD, PhD; K. Nozawa, MD, PhD; T. Hirai, MD; H. Tsushima, MD; E. Hayashi, MD; K. Hiruma, MD; S. Ando, MD, PhD; S. Nakano, MD, PhD; T. Kon, MD, PhD; H. Amano, MD, PhD; K. Yamaji, MD, PhD; N. Tamura, MD, PhD; Y. Takasaki, MD, PhD, Professor, Department of Internal Medicine and Rheumatology, Juntendo University Faculty of Medicine. Address correspondence to Dr. K. Doe, Department of Internal Medicine and Rheumatology, Juntendo University Faculty of Medicine, 2-1-1 Hongo, Bunkyo-ku, Tokyo, 113-8421, Japan. E-mail: kdoe@juntendo.ac.jp. Accepted for publication January 9, 2015.
Takuya Hirai
From the Department of Internal Medicine and Rheumatology, Juntendo University Faculty of Medicine, Tokyo, Japan. K. Doe, MD, PhD; K. Nozawa, MD, PhD; T. Hirai, MD; H. Tsushima, MD; E. Hayashi, MD; K. Hiruma, MD; S. Ando, MD, PhD; S. Nakano, MD, PhD; T. Kon, MD, PhD; H. Amano, MD, PhD; K. Yamaji, MD, PhD; N. Tamura, MD, PhD; Y. Takasaki, MD, PhD, Professor, Department of Internal Medicine and Rheumatology, Juntendo University Faculty of Medicine. Address correspondence to Dr. K. Doe, Department of Internal Medicine and Rheumatology, Juntendo University Faculty of Medicine, 2-1-1 Hongo, Bunkyo-ku, Tokyo, 113-8421, Japan. E-mail: kdoe@juntendo.ac.jp. Accepted for publication January 9, 2015.
Hiroshi Tsushima
From the Department of Internal Medicine and Rheumatology, Juntendo University Faculty of Medicine, Tokyo, Japan. K. Doe, MD, PhD; K. Nozawa, MD, PhD; T. Hirai, MD; H. Tsushima, MD; E. Hayashi, MD; K. Hiruma, MD; S. Ando, MD, PhD; S. Nakano, MD, PhD; T. Kon, MD, PhD; H. Amano, MD, PhD; K. Yamaji, MD, PhD; N. Tamura, MD, PhD; Y. Takasaki, MD, PhD, Professor, Department of Internal Medicine and Rheumatology, Juntendo University Faculty of Medicine. Address correspondence to Dr. K. Doe, Department of Internal Medicine and Rheumatology, Juntendo University Faculty of Medicine, 2-1-1 Hongo, Bunkyo-ku, Tokyo, 113-8421, Japan. E-mail: kdoe@juntendo.ac.jp. Accepted for publication January 9, 2015.
Eri Hayashi
From the Department of Internal Medicine and Rheumatology, Juntendo University Faculty of Medicine, Tokyo, Japan. K. Doe, MD, PhD; K. Nozawa, MD, PhD; T. Hirai, MD; H. Tsushima, MD; E. Hayashi, MD; K. Hiruma, MD; S. Ando, MD, PhD; S. Nakano, MD, PhD; T. Kon, MD, PhD; H. Amano, MD, PhD; K. Yamaji, MD, PhD; N. Tamura, MD, PhD; Y. Takasaki, MD, PhD, Professor, Department of Internal Medicine and Rheumatology, Juntendo University Faculty of Medicine. Address correspondence to Dr. K. Doe, Department of Internal Medicine and Rheumatology, Juntendo University Faculty of Medicine, 2-1-1 Hongo, Bunkyo-ku, Tokyo, 113-8421, Japan. E-mail: kdoe@juntendo.ac.jp. Accepted for publication January 9, 2015.
Kaori Hiruma
From the Department of Internal Medicine and Rheumatology, Juntendo University Faculty of Medicine, Tokyo, Japan. K. Doe, MD, PhD; K. Nozawa, MD, PhD; T. Hirai, MD; H. Tsushima, MD; E. Hayashi, MD; K. Hiruma, MD; S. Ando, MD, PhD; S. Nakano, MD, PhD; T. Kon, MD, PhD; H. Amano, MD, PhD; K. Yamaji, MD, PhD; N. Tamura, MD, PhD; Y. Takasaki, MD, PhD, Professor, Department of Internal Medicine and Rheumatology, Juntendo University Faculty of Medicine. Address correspondence to Dr. K. Doe, Department of Internal Medicine and Rheumatology, Juntendo University Faculty of Medicine, 2-1-1 Hongo, Bunkyo-ku, Tokyo, 113-8421, Japan. E-mail: kdoe@juntendo.ac.jp. Accepted for publication January 9, 2015.
Seiichiro Ando
From the Department of Internal Medicine and Rheumatology, Juntendo University Faculty of Medicine, Tokyo, Japan. K. Doe, MD, PhD; K. Nozawa, MD, PhD; T. Hirai, MD; H. Tsushima, MD; E. Hayashi, MD; K. Hiruma, MD; S. Ando, MD, PhD; S. Nakano, MD, PhD; T. Kon, MD, PhD; H. Amano, MD, PhD; K. Yamaji, MD, PhD; N. Tamura, MD, PhD; Y. Takasaki, MD, PhD, Professor, Department of Internal Medicine and Rheumatology, Juntendo University Faculty of Medicine. Address correspondence to Dr. K. Doe, Department of Internal Medicine and Rheumatology, Juntendo University Faculty of Medicine, 2-1-1 Hongo, Bunkyo-ku, Tokyo, 113-8421, Japan. E-mail: kdoe@juntendo.ac.jp. Accepted for publication January 9, 2015.
Soichiro Nakano
From the Department of Internal Medicine and Rheumatology, Juntendo University Faculty of Medicine, Tokyo, Japan. K. Doe, MD, PhD; K. Nozawa, MD, PhD; T. Hirai, MD; H. Tsushima, MD; E. Hayashi, MD; K. Hiruma, MD; S. Ando, MD, PhD; S. Nakano, MD, PhD; T. Kon, MD, PhD; H. Amano, MD, PhD; K. Yamaji, MD, PhD; N. Tamura, MD, PhD; Y. Takasaki, MD, PhD, Professor, Department of Internal Medicine and Rheumatology, Juntendo University Faculty of Medicine. Address correspondence to Dr. K. Doe, Department of Internal Medicine and Rheumatology, Juntendo University Faculty of Medicine, 2-1-1 Hongo, Bunkyo-ku, Tokyo, 113-8421, Japan. E-mail: kdoe@juntendo.ac.jp. Accepted for publication January 9, 2015.
Takayuki Kon
From the Department of Internal Medicine and Rheumatology, Juntendo University Faculty of Medicine, Tokyo, Japan. K. Doe, MD, PhD; K. Nozawa, MD, PhD; T. Hirai, MD; H. Tsushima, MD; E. Hayashi, MD; K. Hiruma, MD; S. Ando, MD, PhD; S. Nakano, MD, PhD; T. Kon, MD, PhD; H. Amano, MD, PhD; K. Yamaji, MD, PhD; N. Tamura, MD, PhD; Y. Takasaki, MD, PhD, Professor, Department of Internal Medicine and Rheumatology, Juntendo University Faculty of Medicine. Address correspondence to Dr. K. Doe, Department of Internal Medicine and Rheumatology, Juntendo University Faculty of Medicine, 2-1-1 Hongo, Bunkyo-ku, Tokyo, 113-8421, Japan. E-mail: kdoe@juntendo.ac.jp. Accepted for publication January 9, 2015.
Hirofumi Amano
From the Department of Internal Medicine and Rheumatology, Juntendo University Faculty of Medicine, Tokyo, Japan. K. Doe, MD, PhD; K. Nozawa, MD, PhD; T. Hirai, MD; H. Tsushima, MD; E. Hayashi, MD; K. Hiruma, MD; S. Ando, MD, PhD; S. Nakano, MD, PhD; T. Kon, MD, PhD; H. Amano, MD, PhD; K. Yamaji, MD, PhD; N. Tamura, MD, PhD; Y. Takasaki, MD, PhD, Professor, Department of Internal Medicine and Rheumatology, Juntendo University Faculty of Medicine. Address correspondence to Dr. K. Doe, Department of Internal Medicine and Rheumatology, Juntendo University Faculty of Medicine, 2-1-1 Hongo, Bunkyo-ku, Tokyo, 113-8421, Japan. E-mail: kdoe@juntendo.ac.jp. Accepted for publication January 9, 2015.
Ken Yamaji
From the Department of Internal Medicine and Rheumatology, Juntendo University Faculty of Medicine, Tokyo, Japan. K. Doe, MD, PhD; K. Nozawa, MD, PhD; T. Hirai, MD; H. Tsushima, MD; E. Hayashi, MD; K. Hiruma, MD; S. Ando, MD, PhD; S. Nakano, MD, PhD; T. Kon, MD, PhD; H. Amano, MD, PhD; K. Yamaji, MD, PhD; N. Tamura, MD, PhD; Y. Takasaki, MD, PhD, Professor, Department of Internal Medicine and Rheumatology, Juntendo University Faculty of Medicine. Address correspondence to Dr. K. Doe, Department of Internal Medicine and Rheumatology, Juntendo University Faculty of Medicine, 2-1-1 Hongo, Bunkyo-ku, Tokyo, 113-8421, Japan. E-mail: kdoe@juntendo.ac.jp. Accepted for publication January 9, 2015.
Naoto Tamura
From the Department of Internal Medicine and Rheumatology, Juntendo University Faculty of Medicine, Tokyo, Japan. K. Doe, MD, PhD; K. Nozawa, MD, PhD; T. Hirai, MD; H. Tsushima, MD; E. Hayashi, MD; K. Hiruma, MD; S. Ando, MD, PhD; S. Nakano, MD, PhD; T. Kon, MD, PhD; H. Amano, MD, PhD; K. Yamaji, MD, PhD; N. Tamura, MD, PhD; Y. Takasaki, MD, PhD, Professor, Department of Internal Medicine and Rheumatology, Juntendo University Faculty of Medicine. Address correspondence to Dr. K. Doe, Department of Internal Medicine and Rheumatology, Juntendo University Faculty of Medicine, 2-1-1 Hongo, Bunkyo-ku, Tokyo, 113-8421, Japan. E-mail: kdoe@juntendo.ac.jp. Accepted for publication January 9, 2015.
Yoshinari Takasaki
From the Department of Internal Medicine and Rheumatology, Juntendo University Faculty of Medicine, Tokyo, Japan. K. Doe, MD, PhD; K. Nozawa, MD, PhD; T. Hirai, MD; H. Tsushima, MD; E. Hayashi, MD; K. Hiruma, MD; S. Ando, MD, PhD; S. Nakano, MD, PhD; T. Kon, MD, PhD; H. Amano, MD, PhD; K. Yamaji, MD, PhD; N. Tamura, MD, PhD; Y. Takasaki, MD, PhD, Professor, Department of Internal Medicine and Rheumatology, Juntendo University Faculty of Medicine. Address correspondence to Dr. K. Doe, Department of Internal Medicine and Rheumatology, Juntendo University Faculty of Medicine, 2-1-1 Hongo, Bunkyo-ku, Tokyo, 113-8421, Japan. E-mail: kdoe@juntendo.ac.jp. Accepted for publication January 9, 2015.
Abstract
Objective Systemic lupus erythematosus (SLE) occurs predominantly in women, and sex hormones play an important role in SLE. Variation in the second-to-fourth digit ratio (2D4D ratio) is attributed to sex hormone exposure. Therefore, we evaluated the relationship between sex hormones and SLE by measuring 2D4D ratios.
Methods We measured 2D4D ratios in 100 patients with SLE and 200 normal healthy controls (NHC).
Results Patients with SLE had a lower 2D4D ratio than NHC.
Conclusion Our study suggests that patients with SLE have experienced high prenatal testosterone and low prenatal estrogen. To our knowledge, this is the first study evaluating the association between 2D4D ratio and SLE.
In this issue
The Journal of Rheumatology
Vol. 51, Issue 4
1 Apr 2024
Second-to-fourth Digit Ratio in Systemic Lupus Erythematosus
Kentaro Doe, Kazuhisa Nozawa, Takuya Hirai, Hiroshi Tsushima, Eri Hayashi, Kaori Hiruma, Seiichiro Ando, Soichiro Nakano, Takayuki Kon, Hirofumi Amano, Ken Yamaji, Naoto Tamura, Yoshinari Takasaki
The Journal of Rheumatology Mar 2015, jrheum.140974; DOI: 10.3899/jrheum.140974
Second-to-fourth Digit Ratio in Systemic Lupus Erythematosus
Kentaro Doe, Kazuhisa Nozawa, Takuya Hirai, Hiroshi Tsushima, Eri Hayashi, Kaori Hiruma, Seiichiro Ando, Soichiro Nakano, Takayuki Kon, Hirofumi Amano, Ken Yamaji, Naoto Tamura, Yoshinari Takasaki
The Journal of Rheumatology Mar 2015, jrheum.140974; DOI: 10.3899/jrheum.140974