Research ArticleArticle
Effects of Macitentan and Its Active Metabolite on Cultured Human Systemic Sclerosis and Control Skin Fibroblasts
Maurizio Cutolo, Paola Montagna, Renata Brizzolara, Vanessa Smith, Elisa Alessandri, Barbara Villaggio, Alberto Sulli, Pietro Paolo Tavilla, Carmen Pizzorni and Stefano Soldano
The Journal of Rheumatology January 2015, jrheum.141070; DOI: https://doi.org/10.3899/jrheum.141070
Maurizio Cutolo
From Research Laboratory and Academic Division of Clinical Rheumatology, Research Laboratory of Nephrology, Department of Internal Medicine, and the Department of Health Science, Unit of Dermatology, University of Genoa, Genoa, Italy; and the Department of Rheumatology, Ghent University Hospital, Ghent, Belgium. Supported by a research grant from Actelion Pharmaceuticals Ltd. M. Cutolo, MD, Full Professor, Director; P. Montagna, BS, PhD; R. Brizzolara, BS, PhD; E. Alessandri, MD; A. Sulli, MD, Assistant Professor; C. Pizzorni, MD, Assistant Professor; S. Soldano, BS, PhD, Research Laboratory and Academic Division of Clinical Rheumatology; B. Villaggio, BS, Research Laboratory of Nephrology, Department of Internal Medicine; P.P. Tavilla, MD, Department of Health Science, Unit of Dermatology, University of Genoa; V. Smith, MD, PhD, Department of Rheumatology, Ghent University Hospital. Address correspondence to Prof. M. Cutolo, Director of Research Laboratory and Academic Division of Clinical Rheumatology, Department of Internal Medicine, University of Genoa, Viale Benedetto XV/6, 16132 Genoa, Italy. E-mail: mcutolo@unige.it. Accepted for publication November 20, 2014.
Paola Montagna
From Research Laboratory and Academic Division of Clinical Rheumatology, Research Laboratory of Nephrology, Department of Internal Medicine, and the Department of Health Science, Unit of Dermatology, University of Genoa, Genoa, Italy; and the Department of Rheumatology, Ghent University Hospital, Ghent, Belgium. Supported by a research grant from Actelion Pharmaceuticals Ltd. M. Cutolo, MD, Full Professor, Director; P. Montagna, BS, PhD; R. Brizzolara, BS, PhD; E. Alessandri, MD; A. Sulli, MD, Assistant Professor; C. Pizzorni, MD, Assistant Professor; S. Soldano, BS, PhD, Research Laboratory and Academic Division of Clinical Rheumatology; B. Villaggio, BS, Research Laboratory of Nephrology, Department of Internal Medicine; P.P. Tavilla, MD, Department of Health Science, Unit of Dermatology, University of Genoa; V. Smith, MD, PhD, Department of Rheumatology, Ghent University Hospital. Address correspondence to Prof. M. Cutolo, Director of Research Laboratory and Academic Division of Clinical Rheumatology, Department of Internal Medicine, University of Genoa, Viale Benedetto XV/6, 16132 Genoa, Italy. E-mail: mcutolo@unige.it. Accepted for publication November 20, 2014.
Renata Brizzolara
From Research Laboratory and Academic Division of Clinical Rheumatology, Research Laboratory of Nephrology, Department of Internal Medicine, and the Department of Health Science, Unit of Dermatology, University of Genoa, Genoa, Italy; and the Department of Rheumatology, Ghent University Hospital, Ghent, Belgium. Supported by a research grant from Actelion Pharmaceuticals Ltd. M. Cutolo, MD, Full Professor, Director; P. Montagna, BS, PhD; R. Brizzolara, BS, PhD; E. Alessandri, MD; A. Sulli, MD, Assistant Professor; C. Pizzorni, MD, Assistant Professor; S. Soldano, BS, PhD, Research Laboratory and Academic Division of Clinical Rheumatology; B. Villaggio, BS, Research Laboratory of Nephrology, Department of Internal Medicine; P.P. Tavilla, MD, Department of Health Science, Unit of Dermatology, University of Genoa; V. Smith, MD, PhD, Department of Rheumatology, Ghent University Hospital. Address correspondence to Prof. M. Cutolo, Director of Research Laboratory and Academic Division of Clinical Rheumatology, Department of Internal Medicine, University of Genoa, Viale Benedetto XV/6, 16132 Genoa, Italy. E-mail: mcutolo@unige.it. Accepted for publication November 20, 2014.
Vanessa Smith
From Research Laboratory and Academic Division of Clinical Rheumatology, Research Laboratory of Nephrology, Department of Internal Medicine, and the Department of Health Science, Unit of Dermatology, University of Genoa, Genoa, Italy; and the Department of Rheumatology, Ghent University Hospital, Ghent, Belgium. Supported by a research grant from Actelion Pharmaceuticals Ltd. M. Cutolo, MD, Full Professor, Director; P. Montagna, BS, PhD; R. Brizzolara, BS, PhD; E. Alessandri, MD; A. Sulli, MD, Assistant Professor; C. Pizzorni, MD, Assistant Professor; S. Soldano, BS, PhD, Research Laboratory and Academic Division of Clinical Rheumatology; B. Villaggio, BS, Research Laboratory of Nephrology, Department of Internal Medicine; P.P. Tavilla, MD, Department of Health Science, Unit of Dermatology, University of Genoa; V. Smith, MD, PhD, Department of Rheumatology, Ghent University Hospital. Address correspondence to Prof. M. Cutolo, Director of Research Laboratory and Academic Division of Clinical Rheumatology, Department of Internal Medicine, University of Genoa, Viale Benedetto XV/6, 16132 Genoa, Italy. E-mail: mcutolo@unige.it. Accepted for publication November 20, 2014.
Elisa Alessandri
From Research Laboratory and Academic Division of Clinical Rheumatology, Research Laboratory of Nephrology, Department of Internal Medicine, and the Department of Health Science, Unit of Dermatology, University of Genoa, Genoa, Italy; and the Department of Rheumatology, Ghent University Hospital, Ghent, Belgium. Supported by a research grant from Actelion Pharmaceuticals Ltd. M. Cutolo, MD, Full Professor, Director; P. Montagna, BS, PhD; R. Brizzolara, BS, PhD; E. Alessandri, MD; A. Sulli, MD, Assistant Professor; C. Pizzorni, MD, Assistant Professor; S. Soldano, BS, PhD, Research Laboratory and Academic Division of Clinical Rheumatology; B. Villaggio, BS, Research Laboratory of Nephrology, Department of Internal Medicine; P.P. Tavilla, MD, Department of Health Science, Unit of Dermatology, University of Genoa; V. Smith, MD, PhD, Department of Rheumatology, Ghent University Hospital. Address correspondence to Prof. M. Cutolo, Director of Research Laboratory and Academic Division of Clinical Rheumatology, Department of Internal Medicine, University of Genoa, Viale Benedetto XV/6, 16132 Genoa, Italy. E-mail: mcutolo@unige.it. Accepted for publication November 20, 2014.
Barbara Villaggio
From Research Laboratory and Academic Division of Clinical Rheumatology, Research Laboratory of Nephrology, Department of Internal Medicine, and the Department of Health Science, Unit of Dermatology, University of Genoa, Genoa, Italy; and the Department of Rheumatology, Ghent University Hospital, Ghent, Belgium. Supported by a research grant from Actelion Pharmaceuticals Ltd. M. Cutolo, MD, Full Professor, Director; P. Montagna, BS, PhD; R. Brizzolara, BS, PhD; E. Alessandri, MD; A. Sulli, MD, Assistant Professor; C. Pizzorni, MD, Assistant Professor; S. Soldano, BS, PhD, Research Laboratory and Academic Division of Clinical Rheumatology; B. Villaggio, BS, Research Laboratory of Nephrology, Department of Internal Medicine; P.P. Tavilla, MD, Department of Health Science, Unit of Dermatology, University of Genoa; V. Smith, MD, PhD, Department of Rheumatology, Ghent University Hospital. Address correspondence to Prof. M. Cutolo, Director of Research Laboratory and Academic Division of Clinical Rheumatology, Department of Internal Medicine, University of Genoa, Viale Benedetto XV/6, 16132 Genoa, Italy. E-mail: mcutolo@unige.it. Accepted for publication November 20, 2014.
Alberto Sulli
From Research Laboratory and Academic Division of Clinical Rheumatology, Research Laboratory of Nephrology, Department of Internal Medicine, and the Department of Health Science, Unit of Dermatology, University of Genoa, Genoa, Italy; and the Department of Rheumatology, Ghent University Hospital, Ghent, Belgium. Supported by a research grant from Actelion Pharmaceuticals Ltd. M. Cutolo, MD, Full Professor, Director; P. Montagna, BS, PhD; R. Brizzolara, BS, PhD; E. Alessandri, MD; A. Sulli, MD, Assistant Professor; C. Pizzorni, MD, Assistant Professor; S. Soldano, BS, PhD, Research Laboratory and Academic Division of Clinical Rheumatology; B. Villaggio, BS, Research Laboratory of Nephrology, Department of Internal Medicine; P.P. Tavilla, MD, Department of Health Science, Unit of Dermatology, University of Genoa; V. Smith, MD, PhD, Department of Rheumatology, Ghent University Hospital. Address correspondence to Prof. M. Cutolo, Director of Research Laboratory and Academic Division of Clinical Rheumatology, Department of Internal Medicine, University of Genoa, Viale Benedetto XV/6, 16132 Genoa, Italy. E-mail: mcutolo@unige.it. Accepted for publication November 20, 2014.
Pietro Paolo Tavilla
From Research Laboratory and Academic Division of Clinical Rheumatology, Research Laboratory of Nephrology, Department of Internal Medicine, and the Department of Health Science, Unit of Dermatology, University of Genoa, Genoa, Italy; and the Department of Rheumatology, Ghent University Hospital, Ghent, Belgium. Supported by a research grant from Actelion Pharmaceuticals Ltd. M. Cutolo, MD, Full Professor, Director; P. Montagna, BS, PhD; R. Brizzolara, BS, PhD; E. Alessandri, MD; A. Sulli, MD, Assistant Professor; C. Pizzorni, MD, Assistant Professor; S. Soldano, BS, PhD, Research Laboratory and Academic Division of Clinical Rheumatology; B. Villaggio, BS, Research Laboratory of Nephrology, Department of Internal Medicine; P.P. Tavilla, MD, Department of Health Science, Unit of Dermatology, University of Genoa; V. Smith, MD, PhD, Department of Rheumatology, Ghent University Hospital. Address correspondence to Prof. M. Cutolo, Director of Research Laboratory and Academic Division of Clinical Rheumatology, Department of Internal Medicine, University of Genoa, Viale Benedetto XV/6, 16132 Genoa, Italy. E-mail: mcutolo@unige.it. Accepted for publication November 20, 2014.
Carmen Pizzorni
From Research Laboratory and Academic Division of Clinical Rheumatology, Research Laboratory of Nephrology, Department of Internal Medicine, and the Department of Health Science, Unit of Dermatology, University of Genoa, Genoa, Italy; and the Department of Rheumatology, Ghent University Hospital, Ghent, Belgium. Supported by a research grant from Actelion Pharmaceuticals Ltd. M. Cutolo, MD, Full Professor, Director; P. Montagna, BS, PhD; R. Brizzolara, BS, PhD; E. Alessandri, MD; A. Sulli, MD, Assistant Professor; C. Pizzorni, MD, Assistant Professor; S. Soldano, BS, PhD, Research Laboratory and Academic Division of Clinical Rheumatology; B. Villaggio, BS, Research Laboratory of Nephrology, Department of Internal Medicine; P.P. Tavilla, MD, Department of Health Science, Unit of Dermatology, University of Genoa; V. Smith, MD, PhD, Department of Rheumatology, Ghent University Hospital. Address correspondence to Prof. M. Cutolo, Director of Research Laboratory and Academic Division of Clinical Rheumatology, Department of Internal Medicine, University of Genoa, Viale Benedetto XV/6, 16132 Genoa, Italy. E-mail: mcutolo@unige.it. Accepted for publication November 20, 2014.
Stefano Soldano
From Research Laboratory and Academic Division of Clinical Rheumatology, Research Laboratory of Nephrology, Department of Internal Medicine, and the Department of Health Science, Unit of Dermatology, University of Genoa, Genoa, Italy; and the Department of Rheumatology, Ghent University Hospital, Ghent, Belgium. Supported by a research grant from Actelion Pharmaceuticals Ltd. M. Cutolo, MD, Full Professor, Director; P. Montagna, BS, PhD; R. Brizzolara, BS, PhD; E. Alessandri, MD; A. Sulli, MD, Assistant Professor; C. Pizzorni, MD, Assistant Professor; S. Soldano, BS, PhD, Research Laboratory and Academic Division of Clinical Rheumatology; B. Villaggio, BS, Research Laboratory of Nephrology, Department of Internal Medicine; P.P. Tavilla, MD, Department of Health Science, Unit of Dermatology, University of Genoa; V. Smith, MD, PhD, Department of Rheumatology, Ghent University Hospital. Address correspondence to Prof. M. Cutolo, Director of Research Laboratory and Academic Division of Clinical Rheumatology, Department of Internal Medicine, University of Genoa, Viale Benedetto XV/6, 16132 Genoa, Italy. E-mail: mcutolo@unige.it. Accepted for publication November 20, 2014.
In this issue
The Journal of Rheumatology
Vol. 51, Issue 4
1 Apr 2024
Effects of Macitentan and Its Active Metabolite on Cultured Human Systemic Sclerosis and Control Skin Fibroblasts
Maurizio Cutolo, Paola Montagna, Renata Brizzolara, Vanessa Smith, Elisa Alessandri, Barbara Villaggio, Alberto Sulli, Pietro Paolo Tavilla, Carmen Pizzorni, Stefano Soldano
The Journal of Rheumatology Jan 2015, jrheum.141070; DOI: 10.3899/jrheum.141070
Effects of Macitentan and Its Active Metabolite on Cultured Human Systemic Sclerosis and Control Skin Fibroblasts
Maurizio Cutolo, Paola Montagna, Renata Brizzolara, Vanessa Smith, Elisa Alessandri, Barbara Villaggio, Alberto Sulli, Pietro Paolo Tavilla, Carmen Pizzorni, Stefano Soldano
The Journal of Rheumatology Jan 2015, jrheum.141070; DOI: 10.3899/jrheum.141070