Research ArticleArticle
Anti-carbamylated Protein Antibodies Are Present Prior to Rheumatoid Arthritis and Are Associated with Its Future Diagnosis
Ryan W. Gan, Leendert A. Trouw, Jing Shi, René E.M. Toes, Tom W.J. Huizinga, M. Kristen Demoruelle, Jason R. Kolfenbach, Gary O. Zerbe, Kevin D. Deane, Jess D. Edison, William R. Gilliland, Jill M. Norris and V. Michael Holers
The Journal of Rheumatology January 2015, jrheum.140767; DOI: https://doi.org/10.3899/jrheum.140767
Ryan W. Gan
From the Colorado School of Public Health; Division of Rheumatology, University of Colorado Aurora, Colorado; Walter Reed National Military Medical Center, Bethesda, Maryland, USA; and the Department of Rheumatology, Leiden University Medical Center, Leiden, the Netherlands. Supported by a Rheumatology Research Foundation Disease Targeted Innovative Research Grant, National Health Institutes T32 AR007534, the Walter S. and Lucienne Driskill Foundation, the Dutch Arthritis Foundation, the IMI JU funded project BeTheCure contract no 115142-2, The Netherlands Proteomics Center, and the Center for Medical Systems Biology as part of The Netherlands Genomics Initiative. L.T. is supported by a ZON-MW Vidi grant and a fellowship from Janssen Biologics. R.W. Gan, MPH; G.O. Zerbe, PhD; J.M. Norris, PhD, Colorado School of Public Health; L.A. Trouw, PhD; J. Shi; R.E.M. Toes, PhD; T.W.J. Huizinga, MD; Department of Rheumatology, Leiden University Medical Center; M.K. Demoruelle, MD; J.R. Kolfenbach, MD; K.D. Deane, MD; V.M. Holers, MD, Division of Rheumatology, University of Colorado; J.D. Edison, MD; W.R. Gilliland, MD, Walter Reed National Military Medical Center. Address correspondence to Dr. V.M. Holers, University of Colorado School of Medicine, Division of Rheumatology, 1775 Aurora Court, Rm 3102, P.O. Box B115, Aurora, Colorado 80045, USA. E-mail: Michael.Holers@ucdenver.edu. Accepted for publication December 3, 2014.
Leendert A. Trouw
From the Colorado School of Public Health; Division of Rheumatology, University of Colorado Aurora, Colorado; Walter Reed National Military Medical Center, Bethesda, Maryland, USA; and the Department of Rheumatology, Leiden University Medical Center, Leiden, the Netherlands. Supported by a Rheumatology Research Foundation Disease Targeted Innovative Research Grant, National Health Institutes T32 AR007534, the Walter S. and Lucienne Driskill Foundation, the Dutch Arthritis Foundation, the IMI JU funded project BeTheCure contract no 115142-2, The Netherlands Proteomics Center, and the Center for Medical Systems Biology as part of The Netherlands Genomics Initiative. L.T. is supported by a ZON-MW Vidi grant and a fellowship from Janssen Biologics. R.W. Gan, MPH; G.O. Zerbe, PhD; J.M. Norris, PhD, Colorado School of Public Health; L.A. Trouw, PhD; J. Shi; R.E.M. Toes, PhD; T.W.J. Huizinga, MD; Department of Rheumatology, Leiden University Medical Center; M.K. Demoruelle, MD; J.R. Kolfenbach, MD; K.D. Deane, MD; V.M. Holers, MD, Division of Rheumatology, University of Colorado; J.D. Edison, MD; W.R. Gilliland, MD, Walter Reed National Military Medical Center. Address correspondence to Dr. V.M. Holers, University of Colorado School of Medicine, Division of Rheumatology, 1775 Aurora Court, Rm 3102, P.O. Box B115, Aurora, Colorado 80045, USA. E-mail: Michael.Holers@ucdenver.edu. Accepted for publication December 3, 2014.
Jing Shi
From the Colorado School of Public Health; Division of Rheumatology, University of Colorado Aurora, Colorado; Walter Reed National Military Medical Center, Bethesda, Maryland, USA; and the Department of Rheumatology, Leiden University Medical Center, Leiden, the Netherlands. Supported by a Rheumatology Research Foundation Disease Targeted Innovative Research Grant, National Health Institutes T32 AR007534, the Walter S. and Lucienne Driskill Foundation, the Dutch Arthritis Foundation, the IMI JU funded project BeTheCure contract no 115142-2, The Netherlands Proteomics Center, and the Center for Medical Systems Biology as part of The Netherlands Genomics Initiative. L.T. is supported by a ZON-MW Vidi grant and a fellowship from Janssen Biologics. R.W. Gan, MPH; G.O. Zerbe, PhD; J.M. Norris, PhD, Colorado School of Public Health; L.A. Trouw, PhD; J. Shi; R.E.M. Toes, PhD; T.W.J. Huizinga, MD; Department of Rheumatology, Leiden University Medical Center; M.K. Demoruelle, MD; J.R. Kolfenbach, MD; K.D. Deane, MD; V.M. Holers, MD, Division of Rheumatology, University of Colorado; J.D. Edison, MD; W.R. Gilliland, MD, Walter Reed National Military Medical Center. Address correspondence to Dr. V.M. Holers, University of Colorado School of Medicine, Division of Rheumatology, 1775 Aurora Court, Rm 3102, P.O. Box B115, Aurora, Colorado 80045, USA. E-mail: Michael.Holers@ucdenver.edu. Accepted for publication December 3, 2014.
René E.M. Toes
From the Colorado School of Public Health; Division of Rheumatology, University of Colorado Aurora, Colorado; Walter Reed National Military Medical Center, Bethesda, Maryland, USA; and the Department of Rheumatology, Leiden University Medical Center, Leiden, the Netherlands. Supported by a Rheumatology Research Foundation Disease Targeted Innovative Research Grant, National Health Institutes T32 AR007534, the Walter S. and Lucienne Driskill Foundation, the Dutch Arthritis Foundation, the IMI JU funded project BeTheCure contract no 115142-2, The Netherlands Proteomics Center, and the Center for Medical Systems Biology as part of The Netherlands Genomics Initiative. L.T. is supported by a ZON-MW Vidi grant and a fellowship from Janssen Biologics. R.W. Gan, MPH; G.O. Zerbe, PhD; J.M. Norris, PhD, Colorado School of Public Health; L.A. Trouw, PhD; J. Shi; R.E.M. Toes, PhD; T.W.J. Huizinga, MD; Department of Rheumatology, Leiden University Medical Center; M.K. Demoruelle, MD; J.R. Kolfenbach, MD; K.D. Deane, MD; V.M. Holers, MD, Division of Rheumatology, University of Colorado; J.D. Edison, MD; W.R. Gilliland, MD, Walter Reed National Military Medical Center. Address correspondence to Dr. V.M. Holers, University of Colorado School of Medicine, Division of Rheumatology, 1775 Aurora Court, Rm 3102, P.O. Box B115, Aurora, Colorado 80045, USA. E-mail: Michael.Holers@ucdenver.edu. Accepted for publication December 3, 2014.
Tom W.J. Huizinga
From the Colorado School of Public Health; Division of Rheumatology, University of Colorado Aurora, Colorado; Walter Reed National Military Medical Center, Bethesda, Maryland, USA; and the Department of Rheumatology, Leiden University Medical Center, Leiden, the Netherlands. Supported by a Rheumatology Research Foundation Disease Targeted Innovative Research Grant, National Health Institutes T32 AR007534, the Walter S. and Lucienne Driskill Foundation, the Dutch Arthritis Foundation, the IMI JU funded project BeTheCure contract no 115142-2, The Netherlands Proteomics Center, and the Center for Medical Systems Biology as part of The Netherlands Genomics Initiative. L.T. is supported by a ZON-MW Vidi grant and a fellowship from Janssen Biologics. R.W. Gan, MPH; G.O. Zerbe, PhD; J.M. Norris, PhD, Colorado School of Public Health; L.A. Trouw, PhD; J. Shi; R.E.M. Toes, PhD; T.W.J. Huizinga, MD; Department of Rheumatology, Leiden University Medical Center; M.K. Demoruelle, MD; J.R. Kolfenbach, MD; K.D. Deane, MD; V.M. Holers, MD, Division of Rheumatology, University of Colorado; J.D. Edison, MD; W.R. Gilliland, MD, Walter Reed National Military Medical Center. Address correspondence to Dr. V.M. Holers, University of Colorado School of Medicine, Division of Rheumatology, 1775 Aurora Court, Rm 3102, P.O. Box B115, Aurora, Colorado 80045, USA. E-mail: Michael.Holers@ucdenver.edu. Accepted for publication December 3, 2014.
M. Kristen Demoruelle
From the Colorado School of Public Health; Division of Rheumatology, University of Colorado Aurora, Colorado; Walter Reed National Military Medical Center, Bethesda, Maryland, USA; and the Department of Rheumatology, Leiden University Medical Center, Leiden, the Netherlands. Supported by a Rheumatology Research Foundation Disease Targeted Innovative Research Grant, National Health Institutes T32 AR007534, the Walter S. and Lucienne Driskill Foundation, the Dutch Arthritis Foundation, the IMI JU funded project BeTheCure contract no 115142-2, The Netherlands Proteomics Center, and the Center for Medical Systems Biology as part of The Netherlands Genomics Initiative. L.T. is supported by a ZON-MW Vidi grant and a fellowship from Janssen Biologics. R.W. Gan, MPH; G.O. Zerbe, PhD; J.M. Norris, PhD, Colorado School of Public Health; L.A. Trouw, PhD; J. Shi; R.E.M. Toes, PhD; T.W.J. Huizinga, MD; Department of Rheumatology, Leiden University Medical Center; M.K. Demoruelle, MD; J.R. Kolfenbach, MD; K.D. Deane, MD; V.M. Holers, MD, Division of Rheumatology, University of Colorado; J.D. Edison, MD; W.R. Gilliland, MD, Walter Reed National Military Medical Center. Address correspondence to Dr. V.M. Holers, University of Colorado School of Medicine, Division of Rheumatology, 1775 Aurora Court, Rm 3102, P.O. Box B115, Aurora, Colorado 80045, USA. E-mail: Michael.Holers@ucdenver.edu. Accepted for publication December 3, 2014.
Jason R. Kolfenbach
From the Colorado School of Public Health; Division of Rheumatology, University of Colorado Aurora, Colorado; Walter Reed National Military Medical Center, Bethesda, Maryland, USA; and the Department of Rheumatology, Leiden University Medical Center, Leiden, the Netherlands. Supported by a Rheumatology Research Foundation Disease Targeted Innovative Research Grant, National Health Institutes T32 AR007534, the Walter S. and Lucienne Driskill Foundation, the Dutch Arthritis Foundation, the IMI JU funded project BeTheCure contract no 115142-2, The Netherlands Proteomics Center, and the Center for Medical Systems Biology as part of The Netherlands Genomics Initiative. L.T. is supported by a ZON-MW Vidi grant and a fellowship from Janssen Biologics. R.W. Gan, MPH; G.O. Zerbe, PhD; J.M. Norris, PhD, Colorado School of Public Health; L.A. Trouw, PhD; J. Shi; R.E.M. Toes, PhD; T.W.J. Huizinga, MD; Department of Rheumatology, Leiden University Medical Center; M.K. Demoruelle, MD; J.R. Kolfenbach, MD; K.D. Deane, MD; V.M. Holers, MD, Division of Rheumatology, University of Colorado; J.D. Edison, MD; W.R. Gilliland, MD, Walter Reed National Military Medical Center. Address correspondence to Dr. V.M. Holers, University of Colorado School of Medicine, Division of Rheumatology, 1775 Aurora Court, Rm 3102, P.O. Box B115, Aurora, Colorado 80045, USA. E-mail: Michael.Holers@ucdenver.edu. Accepted for publication December 3, 2014.
Gary O. Zerbe
From the Colorado School of Public Health; Division of Rheumatology, University of Colorado Aurora, Colorado; Walter Reed National Military Medical Center, Bethesda, Maryland, USA; and the Department of Rheumatology, Leiden University Medical Center, Leiden, the Netherlands. Supported by a Rheumatology Research Foundation Disease Targeted Innovative Research Grant, National Health Institutes T32 AR007534, the Walter S. and Lucienne Driskill Foundation, the Dutch Arthritis Foundation, the IMI JU funded project BeTheCure contract no 115142-2, The Netherlands Proteomics Center, and the Center for Medical Systems Biology as part of The Netherlands Genomics Initiative. L.T. is supported by a ZON-MW Vidi grant and a fellowship from Janssen Biologics. R.W. Gan, MPH; G.O. Zerbe, PhD; J.M. Norris, PhD, Colorado School of Public Health; L.A. Trouw, PhD; J. Shi; R.E.M. Toes, PhD; T.W.J. Huizinga, MD; Department of Rheumatology, Leiden University Medical Center; M.K. Demoruelle, MD; J.R. Kolfenbach, MD; K.D. Deane, MD; V.M. Holers, MD, Division of Rheumatology, University of Colorado; J.D. Edison, MD; W.R. Gilliland, MD, Walter Reed National Military Medical Center. Address correspondence to Dr. V.M. Holers, University of Colorado School of Medicine, Division of Rheumatology, 1775 Aurora Court, Rm 3102, P.O. Box B115, Aurora, Colorado 80045, USA. E-mail: Michael.Holers@ucdenver.edu. Accepted for publication December 3, 2014.
Kevin D. Deane
From the Colorado School of Public Health; Division of Rheumatology, University of Colorado Aurora, Colorado; Walter Reed National Military Medical Center, Bethesda, Maryland, USA; and the Department of Rheumatology, Leiden University Medical Center, Leiden, the Netherlands. Supported by a Rheumatology Research Foundation Disease Targeted Innovative Research Grant, National Health Institutes T32 AR007534, the Walter S. and Lucienne Driskill Foundation, the Dutch Arthritis Foundation, the IMI JU funded project BeTheCure contract no 115142-2, The Netherlands Proteomics Center, and the Center for Medical Systems Biology as part of The Netherlands Genomics Initiative. L.T. is supported by a ZON-MW Vidi grant and a fellowship from Janssen Biologics. R.W. Gan, MPH; G.O. Zerbe, PhD; J.M. Norris, PhD, Colorado School of Public Health; L.A. Trouw, PhD; J. Shi; R.E.M. Toes, PhD; T.W.J. Huizinga, MD; Department of Rheumatology, Leiden University Medical Center; M.K. Demoruelle, MD; J.R. Kolfenbach, MD; K.D. Deane, MD; V.M. Holers, MD, Division of Rheumatology, University of Colorado; J.D. Edison, MD; W.R. Gilliland, MD, Walter Reed National Military Medical Center. Address correspondence to Dr. V.M. Holers, University of Colorado School of Medicine, Division of Rheumatology, 1775 Aurora Court, Rm 3102, P.O. Box B115, Aurora, Colorado 80045, USA. E-mail: Michael.Holers@ucdenver.edu. Accepted for publication December 3, 2014.
Jess D. Edison
From the Colorado School of Public Health; Division of Rheumatology, University of Colorado Aurora, Colorado; Walter Reed National Military Medical Center, Bethesda, Maryland, USA; and the Department of Rheumatology, Leiden University Medical Center, Leiden, the Netherlands. Supported by a Rheumatology Research Foundation Disease Targeted Innovative Research Grant, National Health Institutes T32 AR007534, the Walter S. and Lucienne Driskill Foundation, the Dutch Arthritis Foundation, the IMI JU funded project BeTheCure contract no 115142-2, The Netherlands Proteomics Center, and the Center for Medical Systems Biology as part of The Netherlands Genomics Initiative. L.T. is supported by a ZON-MW Vidi grant and a fellowship from Janssen Biologics. R.W. Gan, MPH; G.O. Zerbe, PhD; J.M. Norris, PhD, Colorado School of Public Health; L.A. Trouw, PhD; J. Shi; R.E.M. Toes, PhD; T.W.J. Huizinga, MD; Department of Rheumatology, Leiden University Medical Center; M.K. Demoruelle, MD; J.R. Kolfenbach, MD; K.D. Deane, MD; V.M. Holers, MD, Division of Rheumatology, University of Colorado; J.D. Edison, MD; W.R. Gilliland, MD, Walter Reed National Military Medical Center. Address correspondence to Dr. V.M. Holers, University of Colorado School of Medicine, Division of Rheumatology, 1775 Aurora Court, Rm 3102, P.O. Box B115, Aurora, Colorado 80045, USA. E-mail: Michael.Holers@ucdenver.edu. Accepted for publication December 3, 2014.
William R. Gilliland
From the Colorado School of Public Health; Division of Rheumatology, University of Colorado Aurora, Colorado; Walter Reed National Military Medical Center, Bethesda, Maryland, USA; and the Department of Rheumatology, Leiden University Medical Center, Leiden, the Netherlands. Supported by a Rheumatology Research Foundation Disease Targeted Innovative Research Grant, National Health Institutes T32 AR007534, the Walter S. and Lucienne Driskill Foundation, the Dutch Arthritis Foundation, the IMI JU funded project BeTheCure contract no 115142-2, The Netherlands Proteomics Center, and the Center for Medical Systems Biology as part of The Netherlands Genomics Initiative. L.T. is supported by a ZON-MW Vidi grant and a fellowship from Janssen Biologics. R.W. Gan, MPH; G.O. Zerbe, PhD; J.M. Norris, PhD, Colorado School of Public Health; L.A. Trouw, PhD; J. Shi; R.E.M. Toes, PhD; T.W.J. Huizinga, MD; Department of Rheumatology, Leiden University Medical Center; M.K. Demoruelle, MD; J.R. Kolfenbach, MD; K.D. Deane, MD; V.M. Holers, MD, Division of Rheumatology, University of Colorado; J.D. Edison, MD; W.R. Gilliland, MD, Walter Reed National Military Medical Center. Address correspondence to Dr. V.M. Holers, University of Colorado School of Medicine, Division of Rheumatology, 1775 Aurora Court, Rm 3102, P.O. Box B115, Aurora, Colorado 80045, USA. E-mail: Michael.Holers@ucdenver.edu. Accepted for publication December 3, 2014.
Jill M. Norris
From the Colorado School of Public Health; Division of Rheumatology, University of Colorado Aurora, Colorado; Walter Reed National Military Medical Center, Bethesda, Maryland, USA; and the Department of Rheumatology, Leiden University Medical Center, Leiden, the Netherlands. Supported by a Rheumatology Research Foundation Disease Targeted Innovative Research Grant, National Health Institutes T32 AR007534, the Walter S. and Lucienne Driskill Foundation, the Dutch Arthritis Foundation, the IMI JU funded project BeTheCure contract no 115142-2, The Netherlands Proteomics Center, and the Center for Medical Systems Biology as part of The Netherlands Genomics Initiative. L.T. is supported by a ZON-MW Vidi grant and a fellowship from Janssen Biologics. R.W. Gan, MPH; G.O. Zerbe, PhD; J.M. Norris, PhD, Colorado School of Public Health; L.A. Trouw, PhD; J. Shi; R.E.M. Toes, PhD; T.W.J. Huizinga, MD; Department of Rheumatology, Leiden University Medical Center; M.K. Demoruelle, MD; J.R. Kolfenbach, MD; K.D. Deane, MD; V.M. Holers, MD, Division of Rheumatology, University of Colorado; J.D. Edison, MD; W.R. Gilliland, MD, Walter Reed National Military Medical Center. Address correspondence to Dr. V.M. Holers, University of Colorado School of Medicine, Division of Rheumatology, 1775 Aurora Court, Rm 3102, P.O. Box B115, Aurora, Colorado 80045, USA. E-mail: Michael.Holers@ucdenver.edu. Accepted for publication December 3, 2014.
V. Michael Holers
From the Colorado School of Public Health; Division of Rheumatology, University of Colorado Aurora, Colorado; Walter Reed National Military Medical Center, Bethesda, Maryland, USA; and the Department of Rheumatology, Leiden University Medical Center, Leiden, the Netherlands. Supported by a Rheumatology Research Foundation Disease Targeted Innovative Research Grant, National Health Institutes T32 AR007534, the Walter S. and Lucienne Driskill Foundation, the Dutch Arthritis Foundation, the IMI JU funded project BeTheCure contract no 115142-2, The Netherlands Proteomics Center, and the Center for Medical Systems Biology as part of The Netherlands Genomics Initiative. L.T. is supported by a ZON-MW Vidi grant and a fellowship from Janssen Biologics. R.W. Gan, MPH; G.O. Zerbe, PhD; J.M. Norris, PhD, Colorado School of Public Health; L.A. Trouw, PhD; J. Shi; R.E.M. Toes, PhD; T.W.J. Huizinga, MD; Department of Rheumatology, Leiden University Medical Center; M.K. Demoruelle, MD; J.R. Kolfenbach, MD; K.D. Deane, MD; V.M. Holers, MD, Division of Rheumatology, University of Colorado; J.D. Edison, MD; W.R. Gilliland, MD, Walter Reed National Military Medical Center. Address correspondence to Dr. V.M. Holers, University of Colorado School of Medicine, Division of Rheumatology, 1775 Aurora Court, Rm 3102, P.O. Box B115, Aurora, Colorado 80045, USA. E-mail: Michael.Holers@ucdenver.edu. Accepted for publication December 3, 2014.
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In this issue
The Journal of Rheumatology
Vol. 51, Issue 4
1 Apr 2024
Anti-carbamylated Protein Antibodies Are Present Prior to Rheumatoid Arthritis and Are Associated with Its Future Diagnosis
Ryan W. Gan, Leendert A. Trouw, Jing Shi, René E.M. Toes, Tom W.J. Huizinga, M. Kristen Demoruelle, Jason R. Kolfenbach, Gary O. Zerbe, Kevin D. Deane, Jess D. Edison, William R. Gilliland, Jill M. Norris, V. Michael Holers
The Journal of Rheumatology Jan 2015, jrheum.140767; DOI: 10.3899/jrheum.140767
Anti-carbamylated Protein Antibodies Are Present Prior to Rheumatoid Arthritis and Are Associated with Its Future Diagnosis
Ryan W. Gan, Leendert A. Trouw, Jing Shi, René E.M. Toes, Tom W.J. Huizinga, M. Kristen Demoruelle, Jason R. Kolfenbach, Gary O. Zerbe, Kevin D. Deane, Jess D. Edison, William R. Gilliland, Jill M. Norris, V. Michael Holers
The Journal of Rheumatology Jan 2015, jrheum.140767; DOI: 10.3899/jrheum.140767