Research ArticleArticle
Elevation of Serum Immunoglobulin Free Light Chains During the Preclinical Period of Rheumatoid Arthritis
Xiaoli Deng, Cynthia S. Crowson, S. Vincent Rajkumar, Angela Dispenzieri, Dirk R. Larson, Terry M. Therneau, Eric L. Matteson, Robert A. Kyle, Jerry A. Katzmann, Sherine E. Gabriel and John M. Davis III
The Journal of Rheumatology January 2015, jrheum.140543; DOI: https://doi.org/10.3899/jrheum.140543
Xiaoli Deng
From the Department of Rheumatology and Immunology, Peking University Third Hospital, Beijing, China; Department of Health Sciences Research, Department of Medicine, and Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, Minnesota, USA. Supported by the US National Institutes of Health, including grant R01 AR46849 from the National Institute for Arthritis, Musculoskeletal, and Skin Diseases (principal investigator, Dr. Gabriel), grants CA168762 and CA107476 from the National Cancer Institute (principal investigator, Dr. Rajkumar), and grant R01 AG034676 from the National Institute for Aging, supporting the Rochester Epidemiology Project (principal investigator, Dr. Walter A. Rocca). Also supported in part by the Jabbs Foundation (Birmingham, UK) and the Henry J. Predolin Foundation, USA. Binding Site provided the serum immunoglobulin free light chain reagent. X. Deng, MD, Department of Rheumatology and Immunology, Peking University Third Hospital, and formerly Research Trainee, Division of Rheumatology, Departments of Medicine and Immunology, Mayo Clinic; C.S. Crowson, MS, Associate Professor of Medicine, Assistant Professor of Biostatistics; T.M. Therneau, PhD, Professor of Biostatistics, Division of Biomedical Statistics and Informatics, Department of Health Sciences Research; S.V. Rajkumar, MD, Professor of Medicine, Division of Hematology, Department of Medicine; A. Dispenzieri, MD, Professor of Medicine, Professor of Laboratory Medicine and Pathology; R.A. Kyle, MD, Professor of Medicine, Professor of Laboratory Medicine and Pathology, Division of Hematology, Department of Medicine; E.L. Matteson, MD, MPH, Professor of Medicine; S.E. Gabriel, MD, MSc, Professor of Epidemiology, Professor of Medicine, Division of Rheumatology, Department of Medicine, Division of Epidemiology, Department of Health Sciences Research; J.M. Davis III, MD, MS, Associate Professor of Medicine, Division of Rheumatology, Department of Medicine; J.A. Katzmann, PhD, Assistant Professor of Microbiology, Associate Professor of Laboratory Medicine and Pathology, Division of Clinical Biochemistry and Immunology, Department of Laboratory Medicine and Pathology, Mayo Clinic, and the Mayo Clinic College of Medicine; D.R. Larson, MS, Division of Biomedical Statistics and Informatics, Department of Health Sciences Research, Mayo Clinic. Address correspondence to Dr. J.M. Davis III, Mayo Clinic, Mayo Building, 15-73E, 200 1st St. SW, Rochester, Minnesota 55905-0001, USA. E-mail: davis.john4@mayo.edu. Accepted for publication October 23, 2014.
Cynthia S. Crowson
From the Department of Rheumatology and Immunology, Peking University Third Hospital, Beijing, China; Department of Health Sciences Research, Department of Medicine, and Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, Minnesota, USA. Supported by the US National Institutes of Health, including grant R01 AR46849 from the National Institute for Arthritis, Musculoskeletal, and Skin Diseases (principal investigator, Dr. Gabriel), grants CA168762 and CA107476 from the National Cancer Institute (principal investigator, Dr. Rajkumar), and grant R01 AG034676 from the National Institute for Aging, supporting the Rochester Epidemiology Project (principal investigator, Dr. Walter A. Rocca). Also supported in part by the Jabbs Foundation (Birmingham, UK) and the Henry J. Predolin Foundation, USA. Binding Site provided the serum immunoglobulin free light chain reagent. X. Deng, MD, Department of Rheumatology and Immunology, Peking University Third Hospital, and formerly Research Trainee, Division of Rheumatology, Departments of Medicine and Immunology, Mayo Clinic; C.S. Crowson, MS, Associate Professor of Medicine, Assistant Professor of Biostatistics; T.M. Therneau, PhD, Professor of Biostatistics, Division of Biomedical Statistics and Informatics, Department of Health Sciences Research; S.V. Rajkumar, MD, Professor of Medicine, Division of Hematology, Department of Medicine; A. Dispenzieri, MD, Professor of Medicine, Professor of Laboratory Medicine and Pathology; R.A. Kyle, MD, Professor of Medicine, Professor of Laboratory Medicine and Pathology, Division of Hematology, Department of Medicine; E.L. Matteson, MD, MPH, Professor of Medicine; S.E. Gabriel, MD, MSc, Professor of Epidemiology, Professor of Medicine, Division of Rheumatology, Department of Medicine, Division of Epidemiology, Department of Health Sciences Research; J.M. Davis III, MD, MS, Associate Professor of Medicine, Division of Rheumatology, Department of Medicine; J.A. Katzmann, PhD, Assistant Professor of Microbiology, Associate Professor of Laboratory Medicine and Pathology, Division of Clinical Biochemistry and Immunology, Department of Laboratory Medicine and Pathology, Mayo Clinic, and the Mayo Clinic College of Medicine; D.R. Larson, MS, Division of Biomedical Statistics and Informatics, Department of Health Sciences Research, Mayo Clinic. Address correspondence to Dr. J.M. Davis III, Mayo Clinic, Mayo Building, 15-73E, 200 1st St. SW, Rochester, Minnesota 55905-0001, USA. E-mail: davis.john4@mayo.edu. Accepted for publication October 23, 2014.
S. Vincent Rajkumar
From the Department of Rheumatology and Immunology, Peking University Third Hospital, Beijing, China; Department of Health Sciences Research, Department of Medicine, and Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, Minnesota, USA. Supported by the US National Institutes of Health, including grant R01 AR46849 from the National Institute for Arthritis, Musculoskeletal, and Skin Diseases (principal investigator, Dr. Gabriel), grants CA168762 and CA107476 from the National Cancer Institute (principal investigator, Dr. Rajkumar), and grant R01 AG034676 from the National Institute for Aging, supporting the Rochester Epidemiology Project (principal investigator, Dr. Walter A. Rocca). Also supported in part by the Jabbs Foundation (Birmingham, UK) and the Henry J. Predolin Foundation, USA. Binding Site provided the serum immunoglobulin free light chain reagent. X. Deng, MD, Department of Rheumatology and Immunology, Peking University Third Hospital, and formerly Research Trainee, Division of Rheumatology, Departments of Medicine and Immunology, Mayo Clinic; C.S. Crowson, MS, Associate Professor of Medicine, Assistant Professor of Biostatistics; T.M. Therneau, PhD, Professor of Biostatistics, Division of Biomedical Statistics and Informatics, Department of Health Sciences Research; S.V. Rajkumar, MD, Professor of Medicine, Division of Hematology, Department of Medicine; A. Dispenzieri, MD, Professor of Medicine, Professor of Laboratory Medicine and Pathology; R.A. Kyle, MD, Professor of Medicine, Professor of Laboratory Medicine and Pathology, Division of Hematology, Department of Medicine; E.L. Matteson, MD, MPH, Professor of Medicine; S.E. Gabriel, MD, MSc, Professor of Epidemiology, Professor of Medicine, Division of Rheumatology, Department of Medicine, Division of Epidemiology, Department of Health Sciences Research; J.M. Davis III, MD, MS, Associate Professor of Medicine, Division of Rheumatology, Department of Medicine; J.A. Katzmann, PhD, Assistant Professor of Microbiology, Associate Professor of Laboratory Medicine and Pathology, Division of Clinical Biochemistry and Immunology, Department of Laboratory Medicine and Pathology, Mayo Clinic, and the Mayo Clinic College of Medicine; D.R. Larson, MS, Division of Biomedical Statistics and Informatics, Department of Health Sciences Research, Mayo Clinic. Address correspondence to Dr. J.M. Davis III, Mayo Clinic, Mayo Building, 15-73E, 200 1st St. SW, Rochester, Minnesota 55905-0001, USA. E-mail: davis.john4@mayo.edu. Accepted for publication October 23, 2014.
Angela Dispenzieri
From the Department of Rheumatology and Immunology, Peking University Third Hospital, Beijing, China; Department of Health Sciences Research, Department of Medicine, and Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, Minnesota, USA. Supported by the US National Institutes of Health, including grant R01 AR46849 from the National Institute for Arthritis, Musculoskeletal, and Skin Diseases (principal investigator, Dr. Gabriel), grants CA168762 and CA107476 from the National Cancer Institute (principal investigator, Dr. Rajkumar), and grant R01 AG034676 from the National Institute for Aging, supporting the Rochester Epidemiology Project (principal investigator, Dr. Walter A. Rocca). Also supported in part by the Jabbs Foundation (Birmingham, UK) and the Henry J. Predolin Foundation, USA. Binding Site provided the serum immunoglobulin free light chain reagent. X. Deng, MD, Department of Rheumatology and Immunology, Peking University Third Hospital, and formerly Research Trainee, Division of Rheumatology, Departments of Medicine and Immunology, Mayo Clinic; C.S. Crowson, MS, Associate Professor of Medicine, Assistant Professor of Biostatistics; T.M. Therneau, PhD, Professor of Biostatistics, Division of Biomedical Statistics and Informatics, Department of Health Sciences Research; S.V. Rajkumar, MD, Professor of Medicine, Division of Hematology, Department of Medicine; A. Dispenzieri, MD, Professor of Medicine, Professor of Laboratory Medicine and Pathology; R.A. Kyle, MD, Professor of Medicine, Professor of Laboratory Medicine and Pathology, Division of Hematology, Department of Medicine; E.L. Matteson, MD, MPH, Professor of Medicine; S.E. Gabriel, MD, MSc, Professor of Epidemiology, Professor of Medicine, Division of Rheumatology, Department of Medicine, Division of Epidemiology, Department of Health Sciences Research; J.M. Davis III, MD, MS, Associate Professor of Medicine, Division of Rheumatology, Department of Medicine; J.A. Katzmann, PhD, Assistant Professor of Microbiology, Associate Professor of Laboratory Medicine and Pathology, Division of Clinical Biochemistry and Immunology, Department of Laboratory Medicine and Pathology, Mayo Clinic, and the Mayo Clinic College of Medicine; D.R. Larson, MS, Division of Biomedical Statistics and Informatics, Department of Health Sciences Research, Mayo Clinic. Address correspondence to Dr. J.M. Davis III, Mayo Clinic, Mayo Building, 15-73E, 200 1st St. SW, Rochester, Minnesota 55905-0001, USA. E-mail: davis.john4@mayo.edu. Accepted for publication October 23, 2014.
Dirk R. Larson
From the Department of Rheumatology and Immunology, Peking University Third Hospital, Beijing, China; Department of Health Sciences Research, Department of Medicine, and Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, Minnesota, USA. Supported by the US National Institutes of Health, including grant R01 AR46849 from the National Institute for Arthritis, Musculoskeletal, and Skin Diseases (principal investigator, Dr. Gabriel), grants CA168762 and CA107476 from the National Cancer Institute (principal investigator, Dr. Rajkumar), and grant R01 AG034676 from the National Institute for Aging, supporting the Rochester Epidemiology Project (principal investigator, Dr. Walter A. Rocca). Also supported in part by the Jabbs Foundation (Birmingham, UK) and the Henry J. Predolin Foundation, USA. Binding Site provided the serum immunoglobulin free light chain reagent. X. Deng, MD, Department of Rheumatology and Immunology, Peking University Third Hospital, and formerly Research Trainee, Division of Rheumatology, Departments of Medicine and Immunology, Mayo Clinic; C.S. Crowson, MS, Associate Professor of Medicine, Assistant Professor of Biostatistics; T.M. Therneau, PhD, Professor of Biostatistics, Division of Biomedical Statistics and Informatics, Department of Health Sciences Research; S.V. Rajkumar, MD, Professor of Medicine, Division of Hematology, Department of Medicine; A. Dispenzieri, MD, Professor of Medicine, Professor of Laboratory Medicine and Pathology; R.A. Kyle, MD, Professor of Medicine, Professor of Laboratory Medicine and Pathology, Division of Hematology, Department of Medicine; E.L. Matteson, MD, MPH, Professor of Medicine; S.E. Gabriel, MD, MSc, Professor of Epidemiology, Professor of Medicine, Division of Rheumatology, Department of Medicine, Division of Epidemiology, Department of Health Sciences Research; J.M. Davis III, MD, MS, Associate Professor of Medicine, Division of Rheumatology, Department of Medicine; J.A. Katzmann, PhD, Assistant Professor of Microbiology, Associate Professor of Laboratory Medicine and Pathology, Division of Clinical Biochemistry and Immunology, Department of Laboratory Medicine and Pathology, Mayo Clinic, and the Mayo Clinic College of Medicine; D.R. Larson, MS, Division of Biomedical Statistics and Informatics, Department of Health Sciences Research, Mayo Clinic. Address correspondence to Dr. J.M. Davis III, Mayo Clinic, Mayo Building, 15-73E, 200 1st St. SW, Rochester, Minnesota 55905-0001, USA. E-mail: davis.john4@mayo.edu. Accepted for publication October 23, 2014.
Terry M. Therneau
From the Department of Rheumatology and Immunology, Peking University Third Hospital, Beijing, China; Department of Health Sciences Research, Department of Medicine, and Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, Minnesota, USA. Supported by the US National Institutes of Health, including grant R01 AR46849 from the National Institute for Arthritis, Musculoskeletal, and Skin Diseases (principal investigator, Dr. Gabriel), grants CA168762 and CA107476 from the National Cancer Institute (principal investigator, Dr. Rajkumar), and grant R01 AG034676 from the National Institute for Aging, supporting the Rochester Epidemiology Project (principal investigator, Dr. Walter A. Rocca). Also supported in part by the Jabbs Foundation (Birmingham, UK) and the Henry J. Predolin Foundation, USA. Binding Site provided the serum immunoglobulin free light chain reagent. X. Deng, MD, Department of Rheumatology and Immunology, Peking University Third Hospital, and formerly Research Trainee, Division of Rheumatology, Departments of Medicine and Immunology, Mayo Clinic; C.S. Crowson, MS, Associate Professor of Medicine, Assistant Professor of Biostatistics; T.M. Therneau, PhD, Professor of Biostatistics, Division of Biomedical Statistics and Informatics, Department of Health Sciences Research; S.V. Rajkumar, MD, Professor of Medicine, Division of Hematology, Department of Medicine; A. Dispenzieri, MD, Professor of Medicine, Professor of Laboratory Medicine and Pathology; R.A. Kyle, MD, Professor of Medicine, Professor of Laboratory Medicine and Pathology, Division of Hematology, Department of Medicine; E.L. Matteson, MD, MPH, Professor of Medicine; S.E. Gabriel, MD, MSc, Professor of Epidemiology, Professor of Medicine, Division of Rheumatology, Department of Medicine, Division of Epidemiology, Department of Health Sciences Research; J.M. Davis III, MD, MS, Associate Professor of Medicine, Division of Rheumatology, Department of Medicine; J.A. Katzmann, PhD, Assistant Professor of Microbiology, Associate Professor of Laboratory Medicine and Pathology, Division of Clinical Biochemistry and Immunology, Department of Laboratory Medicine and Pathology, Mayo Clinic, and the Mayo Clinic College of Medicine; D.R. Larson, MS, Division of Biomedical Statistics and Informatics, Department of Health Sciences Research, Mayo Clinic. Address correspondence to Dr. J.M. Davis III, Mayo Clinic, Mayo Building, 15-73E, 200 1st St. SW, Rochester, Minnesota 55905-0001, USA. E-mail: davis.john4@mayo.edu. Accepted for publication October 23, 2014.
Eric L. Matteson
From the Department of Rheumatology and Immunology, Peking University Third Hospital, Beijing, China; Department of Health Sciences Research, Department of Medicine, and Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, Minnesota, USA. Supported by the US National Institutes of Health, including grant R01 AR46849 from the National Institute for Arthritis, Musculoskeletal, and Skin Diseases (principal investigator, Dr. Gabriel), grants CA168762 and CA107476 from the National Cancer Institute (principal investigator, Dr. Rajkumar), and grant R01 AG034676 from the National Institute for Aging, supporting the Rochester Epidemiology Project (principal investigator, Dr. Walter A. Rocca). Also supported in part by the Jabbs Foundation (Birmingham, UK) and the Henry J. Predolin Foundation, USA. Binding Site provided the serum immunoglobulin free light chain reagent. X. Deng, MD, Department of Rheumatology and Immunology, Peking University Third Hospital, and formerly Research Trainee, Division of Rheumatology, Departments of Medicine and Immunology, Mayo Clinic; C.S. Crowson, MS, Associate Professor of Medicine, Assistant Professor of Biostatistics; T.M. Therneau, PhD, Professor of Biostatistics, Division of Biomedical Statistics and Informatics, Department of Health Sciences Research; S.V. Rajkumar, MD, Professor of Medicine, Division of Hematology, Department of Medicine; A. Dispenzieri, MD, Professor of Medicine, Professor of Laboratory Medicine and Pathology; R.A. Kyle, MD, Professor of Medicine, Professor of Laboratory Medicine and Pathology, Division of Hematology, Department of Medicine; E.L. Matteson, MD, MPH, Professor of Medicine; S.E. Gabriel, MD, MSc, Professor of Epidemiology, Professor of Medicine, Division of Rheumatology, Department of Medicine, Division of Epidemiology, Department of Health Sciences Research; J.M. Davis III, MD, MS, Associate Professor of Medicine, Division of Rheumatology, Department of Medicine; J.A. Katzmann, PhD, Assistant Professor of Microbiology, Associate Professor of Laboratory Medicine and Pathology, Division of Clinical Biochemistry and Immunology, Department of Laboratory Medicine and Pathology, Mayo Clinic, and the Mayo Clinic College of Medicine; D.R. Larson, MS, Division of Biomedical Statistics and Informatics, Department of Health Sciences Research, Mayo Clinic. Address correspondence to Dr. J.M. Davis III, Mayo Clinic, Mayo Building, 15-73E, 200 1st St. SW, Rochester, Minnesota 55905-0001, USA. E-mail: davis.john4@mayo.edu. Accepted for publication October 23, 2014.
Robert A. Kyle
From the Department of Rheumatology and Immunology, Peking University Third Hospital, Beijing, China; Department of Health Sciences Research, Department of Medicine, and Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, Minnesota, USA. Supported by the US National Institutes of Health, including grant R01 AR46849 from the National Institute for Arthritis, Musculoskeletal, and Skin Diseases (principal investigator, Dr. Gabriel), grants CA168762 and CA107476 from the National Cancer Institute (principal investigator, Dr. Rajkumar), and grant R01 AG034676 from the National Institute for Aging, supporting the Rochester Epidemiology Project (principal investigator, Dr. Walter A. Rocca). Also supported in part by the Jabbs Foundation (Birmingham, UK) and the Henry J. Predolin Foundation, USA. Binding Site provided the serum immunoglobulin free light chain reagent. X. Deng, MD, Department of Rheumatology and Immunology, Peking University Third Hospital, and formerly Research Trainee, Division of Rheumatology, Departments of Medicine and Immunology, Mayo Clinic; C.S. Crowson, MS, Associate Professor of Medicine, Assistant Professor of Biostatistics; T.M. Therneau, PhD, Professor of Biostatistics, Division of Biomedical Statistics and Informatics, Department of Health Sciences Research; S.V. Rajkumar, MD, Professor of Medicine, Division of Hematology, Department of Medicine; A. Dispenzieri, MD, Professor of Medicine, Professor of Laboratory Medicine and Pathology; R.A. Kyle, MD, Professor of Medicine, Professor of Laboratory Medicine and Pathology, Division of Hematology, Department of Medicine; E.L. Matteson, MD, MPH, Professor of Medicine; S.E. Gabriel, MD, MSc, Professor of Epidemiology, Professor of Medicine, Division of Rheumatology, Department of Medicine, Division of Epidemiology, Department of Health Sciences Research; J.M. Davis III, MD, MS, Associate Professor of Medicine, Division of Rheumatology, Department of Medicine; J.A. Katzmann, PhD, Assistant Professor of Microbiology, Associate Professor of Laboratory Medicine and Pathology, Division of Clinical Biochemistry and Immunology, Department of Laboratory Medicine and Pathology, Mayo Clinic, and the Mayo Clinic College of Medicine; D.R. Larson, MS, Division of Biomedical Statistics and Informatics, Department of Health Sciences Research, Mayo Clinic. Address correspondence to Dr. J.M. Davis III, Mayo Clinic, Mayo Building, 15-73E, 200 1st St. SW, Rochester, Minnesota 55905-0001, USA. E-mail: davis.john4@mayo.edu. Accepted for publication October 23, 2014.
Jerry A. Katzmann
From the Department of Rheumatology and Immunology, Peking University Third Hospital, Beijing, China; Department of Health Sciences Research, Department of Medicine, and Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, Minnesota, USA. Supported by the US National Institutes of Health, including grant R01 AR46849 from the National Institute for Arthritis, Musculoskeletal, and Skin Diseases (principal investigator, Dr. Gabriel), grants CA168762 and CA107476 from the National Cancer Institute (principal investigator, Dr. Rajkumar), and grant R01 AG034676 from the National Institute for Aging, supporting the Rochester Epidemiology Project (principal investigator, Dr. Walter A. Rocca). Also supported in part by the Jabbs Foundation (Birmingham, UK) and the Henry J. Predolin Foundation, USA. Binding Site provided the serum immunoglobulin free light chain reagent. X. Deng, MD, Department of Rheumatology and Immunology, Peking University Third Hospital, and formerly Research Trainee, Division of Rheumatology, Departments of Medicine and Immunology, Mayo Clinic; C.S. Crowson, MS, Associate Professor of Medicine, Assistant Professor of Biostatistics; T.M. Therneau, PhD, Professor of Biostatistics, Division of Biomedical Statistics and Informatics, Department of Health Sciences Research; S.V. Rajkumar, MD, Professor of Medicine, Division of Hematology, Department of Medicine; A. Dispenzieri, MD, Professor of Medicine, Professor of Laboratory Medicine and Pathology; R.A. Kyle, MD, Professor of Medicine, Professor of Laboratory Medicine and Pathology, Division of Hematology, Department of Medicine; E.L. Matteson, MD, MPH, Professor of Medicine; S.E. Gabriel, MD, MSc, Professor of Epidemiology, Professor of Medicine, Division of Rheumatology, Department of Medicine, Division of Epidemiology, Department of Health Sciences Research; J.M. Davis III, MD, MS, Associate Professor of Medicine, Division of Rheumatology, Department of Medicine; J.A. Katzmann, PhD, Assistant Professor of Microbiology, Associate Professor of Laboratory Medicine and Pathology, Division of Clinical Biochemistry and Immunology, Department of Laboratory Medicine and Pathology, Mayo Clinic, and the Mayo Clinic College of Medicine; D.R. Larson, MS, Division of Biomedical Statistics and Informatics, Department of Health Sciences Research, Mayo Clinic. Address correspondence to Dr. J.M. Davis III, Mayo Clinic, Mayo Building, 15-73E, 200 1st St. SW, Rochester, Minnesota 55905-0001, USA. E-mail: davis.john4@mayo.edu. Accepted for publication October 23, 2014.
Sherine E. Gabriel
From the Department of Rheumatology and Immunology, Peking University Third Hospital, Beijing, China; Department of Health Sciences Research, Department of Medicine, and Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, Minnesota, USA. Supported by the US National Institutes of Health, including grant R01 AR46849 from the National Institute for Arthritis, Musculoskeletal, and Skin Diseases (principal investigator, Dr. Gabriel), grants CA168762 and CA107476 from the National Cancer Institute (principal investigator, Dr. Rajkumar), and grant R01 AG034676 from the National Institute for Aging, supporting the Rochester Epidemiology Project (principal investigator, Dr. Walter A. Rocca). Also supported in part by the Jabbs Foundation (Birmingham, UK) and the Henry J. Predolin Foundation, USA. Binding Site provided the serum immunoglobulin free light chain reagent. X. Deng, MD, Department of Rheumatology and Immunology, Peking University Third Hospital, and formerly Research Trainee, Division of Rheumatology, Departments of Medicine and Immunology, Mayo Clinic; C.S. Crowson, MS, Associate Professor of Medicine, Assistant Professor of Biostatistics; T.M. Therneau, PhD, Professor of Biostatistics, Division of Biomedical Statistics and Informatics, Department of Health Sciences Research; S.V. Rajkumar, MD, Professor of Medicine, Division of Hematology, Department of Medicine; A. Dispenzieri, MD, Professor of Medicine, Professor of Laboratory Medicine and Pathology; R.A. Kyle, MD, Professor of Medicine, Professor of Laboratory Medicine and Pathology, Division of Hematology, Department of Medicine; E.L. Matteson, MD, MPH, Professor of Medicine; S.E. Gabriel, MD, MSc, Professor of Epidemiology, Professor of Medicine, Division of Rheumatology, Department of Medicine, Division of Epidemiology, Department of Health Sciences Research; J.M. Davis III, MD, MS, Associate Professor of Medicine, Division of Rheumatology, Department of Medicine; J.A. Katzmann, PhD, Assistant Professor of Microbiology, Associate Professor of Laboratory Medicine and Pathology, Division of Clinical Biochemistry and Immunology, Department of Laboratory Medicine and Pathology, Mayo Clinic, and the Mayo Clinic College of Medicine; D.R. Larson, MS, Division of Biomedical Statistics and Informatics, Department of Health Sciences Research, Mayo Clinic. Address correspondence to Dr. J.M. Davis III, Mayo Clinic, Mayo Building, 15-73E, 200 1st St. SW, Rochester, Minnesota 55905-0001, USA. E-mail: davis.john4@mayo.edu. Accepted for publication October 23, 2014.
John M. Davis III
From the Department of Rheumatology and Immunology, Peking University Third Hospital, Beijing, China; Department of Health Sciences Research, Department of Medicine, and Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, Minnesota, USA. Supported by the US National Institutes of Health, including grant R01 AR46849 from the National Institute for Arthritis, Musculoskeletal, and Skin Diseases (principal investigator, Dr. Gabriel), grants CA168762 and CA107476 from the National Cancer Institute (principal investigator, Dr. Rajkumar), and grant R01 AG034676 from the National Institute for Aging, supporting the Rochester Epidemiology Project (principal investigator, Dr. Walter A. Rocca). Also supported in part by the Jabbs Foundation (Birmingham, UK) and the Henry J. Predolin Foundation, USA. Binding Site provided the serum immunoglobulin free light chain reagent. X. Deng, MD, Department of Rheumatology and Immunology, Peking University Third Hospital, and formerly Research Trainee, Division of Rheumatology, Departments of Medicine and Immunology, Mayo Clinic; C.S. Crowson, MS, Associate Professor of Medicine, Assistant Professor of Biostatistics; T.M. Therneau, PhD, Professor of Biostatistics, Division of Biomedical Statistics and Informatics, Department of Health Sciences Research; S.V. Rajkumar, MD, Professor of Medicine, Division of Hematology, Department of Medicine; A. Dispenzieri, MD, Professor of Medicine, Professor of Laboratory Medicine and Pathology; R.A. Kyle, MD, Professor of Medicine, Professor of Laboratory Medicine and Pathology, Division of Hematology, Department of Medicine; E.L. Matteson, MD, MPH, Professor of Medicine; S.E. Gabriel, MD, MSc, Professor of Epidemiology, Professor of Medicine, Division of Rheumatology, Department of Medicine, Division of Epidemiology, Department of Health Sciences Research; J.M. Davis III, MD, MS, Associate Professor of Medicine, Division of Rheumatology, Department of Medicine; J.A. Katzmann, PhD, Assistant Professor of Microbiology, Associate Professor of Laboratory Medicine and Pathology, Division of Clinical Biochemistry and Immunology, Department of Laboratory Medicine and Pathology, Mayo Clinic, and the Mayo Clinic College of Medicine; D.R. Larson, MS, Division of Biomedical Statistics and Informatics, Department of Health Sciences Research, Mayo Clinic. Address correspondence to Dr. J.M. Davis III, Mayo Clinic, Mayo Building, 15-73E, 200 1st St. SW, Rochester, Minnesota 55905-0001, USA. E-mail: davis.john4@mayo.edu. Accepted for publication October 23, 2014.
In this issue
The Journal of Rheumatology
Vol. 51, Issue 3
1 Mar 2024
Elevation of Serum Immunoglobulin Free Light Chains During the Preclinical Period of Rheumatoid Arthritis
Xiaoli Deng, Cynthia S. Crowson, S. Vincent Rajkumar, Angela Dispenzieri, Dirk R. Larson, Terry M. Therneau, Eric L. Matteson, Robert A. Kyle, Jerry A. Katzmann, Sherine E. Gabriel, John M. Davis
The Journal of Rheumatology Jan 2015, jrheum.140543; DOI: 10.3899/jrheum.140543
Elevation of Serum Immunoglobulin Free Light Chains During the Preclinical Period of Rheumatoid Arthritis
Xiaoli Deng, Cynthia S. Crowson, S. Vincent Rajkumar, Angela Dispenzieri, Dirk R. Larson, Terry M. Therneau, Eric L. Matteson, Robert A. Kyle, Jerry A. Katzmann, Sherine E. Gabriel, John M. Davis
The Journal of Rheumatology Jan 2015, jrheum.140543; DOI: 10.3899/jrheum.140543