Research ArticleArticle
Etiopathogenic Role of Surfactant Protein D in the Clinical and Immunological Expression of Primary Sjögren Syndrome
María José Soto-Cárdenas, Myriam Gandía, Pilar Brito-Zerón, Maria Teresa Arias, Noelia Armiger, Albert Bové, Xavier Bosch, Soledad Retamozo, Miriam Akasbi, Marta Pérez-De-Lis, Hoda Gueitasi, Belchin Kostov, Roberto Pérez-Alvarez, Antoni Siso-Almirall, Francisco Lozano and Manuel Ramos-Casals
The Journal of Rheumatology November 2014, jrheum.140394; DOI: https://doi.org/10.3899/jrheum.140394
María José Soto-Cárdenas
From the Sjögren Syndrome Research Group (AGAUR), Laboratory of Autoimmune Diseases Josep Font, Institut d’Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS); Department of Autoimmune Diseases, Department of Internal Medicine, Instituto Clínic de Medicina y Dermatología, Immunology Department, Hospital Clínic; Primary Care Research Group, Centre d’Assistència Primària ABS Les Corts, GESCLINIC; Department of Cell Biology, Immunology and Neurosciences, School of Medicine, University of Barcelona, Barcelona; Group of Immunoreceptors, Department of Internal Medicine, Hospital Infanta Leonor, Madrid; Department of Internal Medicine, Hospital do Meixoeiro, Vigo; Department of Internal Medicine, University of Cadiz, Hospital Puerta del Mar, Cádiz, Spain. Supported by Grants La Marató de TV3 (071810), Fondo de Investigaciones Sanitarias (080103/1201009), and “Ajut per a la Recerca Josep Font” from Hospital Clinic-Barcelona (PBZ, 2012). M.J. Soto-Cárdenas, MD, PhD; M. Gandía, MD, PhD, AGAUR, Laboratory of Autoimmune Diseases Josep Font, IDIBAPS, Department of Autoimmune Diseases, and the Department of Internal Medicine, University of Cadiz, Hospital Puerta del Mar; P. Brito-Zerón, MD, PhD; A. Bové, MD, PhD; S. Retamozo, MD; H. Gueitasi, MD; M. Ramos-Casals, MD, PhD, AGAUR, Laboratory of Autoimmune Diseases Josep Font, IDIBAPS, Department of Autoimmune Diseases; M.T. Arias, BSc, Immunology Department, Hospital Clínic; N. Armiger, BSc, Group of Immunoreceptors, IDIBAPS; X. Bosch, MD, PhD, Department of Internal Medicine, Instituto Clínic de Medicina y Dermatología; M. Akasbi, MD, PhD, Department of Internal Medicine, Hospital Infanta Leonor; M. Pérez-De-Lis, MD, PhD; R. Pérez-Alvarez, MD, PhD, Department of Internal Medicine, Hospital do Meixoeiro; B. Kostov, MSC; A. Siso-Almirall, MD, PhD, Primary Care Research Group, IDIBAPS, Centre d’Assistència Primària ABS Les Corts, GESCLINIC; F. Lozano, MD, PhD, Immunology Department, Hospital Clínic, Barcelona, and the Group of Immunoreceptors, IDIBAPS, and the Department of Cell Biology, Immunology and Neurosciences, School of Medicine, University of Barcelona. Address correspondence to Dr. M. Ramos-Casals, Servei de Malalties Autoimmunes, Hospital Clínic, C/Villarroel 170, 08036-Barcelona, Spain. E-mail: mramos@clinic.ub.es. Accepted for publication September 12, 2014.
Myriam Gandía
From the Sjögren Syndrome Research Group (AGAUR), Laboratory of Autoimmune Diseases Josep Font, Institut d’Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS); Department of Autoimmune Diseases, Department of Internal Medicine, Instituto Clínic de Medicina y Dermatología, Immunology Department, Hospital Clínic; Primary Care Research Group, Centre d’Assistència Primària ABS Les Corts, GESCLINIC; Department of Cell Biology, Immunology and Neurosciences, School of Medicine, University of Barcelona, Barcelona; Group of Immunoreceptors, Department of Internal Medicine, Hospital Infanta Leonor, Madrid; Department of Internal Medicine, Hospital do Meixoeiro, Vigo; Department of Internal Medicine, University of Cadiz, Hospital Puerta del Mar, Cádiz, Spain. Supported by Grants La Marató de TV3 (071810), Fondo de Investigaciones Sanitarias (080103/1201009), and “Ajut per a la Recerca Josep Font” from Hospital Clinic-Barcelona (PBZ, 2012). M.J. Soto-Cárdenas, MD, PhD; M. Gandía, MD, PhD, AGAUR, Laboratory of Autoimmune Diseases Josep Font, IDIBAPS, Department of Autoimmune Diseases, and the Department of Internal Medicine, University of Cadiz, Hospital Puerta del Mar; P. Brito-Zerón, MD, PhD; A. Bové, MD, PhD; S. Retamozo, MD; H. Gueitasi, MD; M. Ramos-Casals, MD, PhD, AGAUR, Laboratory of Autoimmune Diseases Josep Font, IDIBAPS, Department of Autoimmune Diseases; M.T. Arias, BSc, Immunology Department, Hospital Clínic; N. Armiger, BSc, Group of Immunoreceptors, IDIBAPS; X. Bosch, MD, PhD, Department of Internal Medicine, Instituto Clínic de Medicina y Dermatología; M. Akasbi, MD, PhD, Department of Internal Medicine, Hospital Infanta Leonor; M. Pérez-De-Lis, MD, PhD; R. Pérez-Alvarez, MD, PhD, Department of Internal Medicine, Hospital do Meixoeiro; B. Kostov, MSC; A. Siso-Almirall, MD, PhD, Primary Care Research Group, IDIBAPS, Centre d’Assistència Primària ABS Les Corts, GESCLINIC; F. Lozano, MD, PhD, Immunology Department, Hospital Clínic, Barcelona, and the Group of Immunoreceptors, IDIBAPS, and the Department of Cell Biology, Immunology and Neurosciences, School of Medicine, University of Barcelona. Address correspondence to Dr. M. Ramos-Casals, Servei de Malalties Autoimmunes, Hospital Clínic, C/Villarroel 170, 08036-Barcelona, Spain. E-mail: mramos@clinic.ub.es. Accepted for publication September 12, 2014.
Pilar Brito-Zerón
From the Sjögren Syndrome Research Group (AGAUR), Laboratory of Autoimmune Diseases Josep Font, Institut d’Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS); Department of Autoimmune Diseases, Department of Internal Medicine, Instituto Clínic de Medicina y Dermatología, Immunology Department, Hospital Clínic; Primary Care Research Group, Centre d’Assistència Primària ABS Les Corts, GESCLINIC; Department of Cell Biology, Immunology and Neurosciences, School of Medicine, University of Barcelona, Barcelona; Group of Immunoreceptors, Department of Internal Medicine, Hospital Infanta Leonor, Madrid; Department of Internal Medicine, Hospital do Meixoeiro, Vigo; Department of Internal Medicine, University of Cadiz, Hospital Puerta del Mar, Cádiz, Spain. Supported by Grants La Marató de TV3 (071810), Fondo de Investigaciones Sanitarias (080103/1201009), and “Ajut per a la Recerca Josep Font” from Hospital Clinic-Barcelona (PBZ, 2012). M.J. Soto-Cárdenas, MD, PhD; M. Gandía, MD, PhD, AGAUR, Laboratory of Autoimmune Diseases Josep Font, IDIBAPS, Department of Autoimmune Diseases, and the Department of Internal Medicine, University of Cadiz, Hospital Puerta del Mar; P. Brito-Zerón, MD, PhD; A. Bové, MD, PhD; S. Retamozo, MD; H. Gueitasi, MD; M. Ramos-Casals, MD, PhD, AGAUR, Laboratory of Autoimmune Diseases Josep Font, IDIBAPS, Department of Autoimmune Diseases; M.T. Arias, BSc, Immunology Department, Hospital Clínic; N. Armiger, BSc, Group of Immunoreceptors, IDIBAPS; X. Bosch, MD, PhD, Department of Internal Medicine, Instituto Clínic de Medicina y Dermatología; M. Akasbi, MD, PhD, Department of Internal Medicine, Hospital Infanta Leonor; M. Pérez-De-Lis, MD, PhD; R. Pérez-Alvarez, MD, PhD, Department of Internal Medicine, Hospital do Meixoeiro; B. Kostov, MSC; A. Siso-Almirall, MD, PhD, Primary Care Research Group, IDIBAPS, Centre d’Assistència Primària ABS Les Corts, GESCLINIC; F. Lozano, MD, PhD, Immunology Department, Hospital Clínic, Barcelona, and the Group of Immunoreceptors, IDIBAPS, and the Department of Cell Biology, Immunology and Neurosciences, School of Medicine, University of Barcelona. Address correspondence to Dr. M. Ramos-Casals, Servei de Malalties Autoimmunes, Hospital Clínic, C/Villarroel 170, 08036-Barcelona, Spain. E-mail: mramos@clinic.ub.es. Accepted for publication September 12, 2014.
Maria Teresa Arias
From the Sjögren Syndrome Research Group (AGAUR), Laboratory of Autoimmune Diseases Josep Font, Institut d’Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS); Department of Autoimmune Diseases, Department of Internal Medicine, Instituto Clínic de Medicina y Dermatología, Immunology Department, Hospital Clínic; Primary Care Research Group, Centre d’Assistència Primària ABS Les Corts, GESCLINIC; Department of Cell Biology, Immunology and Neurosciences, School of Medicine, University of Barcelona, Barcelona; Group of Immunoreceptors, Department of Internal Medicine, Hospital Infanta Leonor, Madrid; Department of Internal Medicine, Hospital do Meixoeiro, Vigo; Department of Internal Medicine, University of Cadiz, Hospital Puerta del Mar, Cádiz, Spain. Supported by Grants La Marató de TV3 (071810), Fondo de Investigaciones Sanitarias (080103/1201009), and “Ajut per a la Recerca Josep Font” from Hospital Clinic-Barcelona (PBZ, 2012). M.J. Soto-Cárdenas, MD, PhD; M. Gandía, MD, PhD, AGAUR, Laboratory of Autoimmune Diseases Josep Font, IDIBAPS, Department of Autoimmune Diseases, and the Department of Internal Medicine, University of Cadiz, Hospital Puerta del Mar; P. Brito-Zerón, MD, PhD; A. Bové, MD, PhD; S. Retamozo, MD; H. Gueitasi, MD; M. Ramos-Casals, MD, PhD, AGAUR, Laboratory of Autoimmune Diseases Josep Font, IDIBAPS, Department of Autoimmune Diseases; M.T. Arias, BSc, Immunology Department, Hospital Clínic; N. Armiger, BSc, Group of Immunoreceptors, IDIBAPS; X. Bosch, MD, PhD, Department of Internal Medicine, Instituto Clínic de Medicina y Dermatología; M. Akasbi, MD, PhD, Department of Internal Medicine, Hospital Infanta Leonor; M. Pérez-De-Lis, MD, PhD; R. Pérez-Alvarez, MD, PhD, Department of Internal Medicine, Hospital do Meixoeiro; B. Kostov, MSC; A. Siso-Almirall, MD, PhD, Primary Care Research Group, IDIBAPS, Centre d’Assistència Primària ABS Les Corts, GESCLINIC; F. Lozano, MD, PhD, Immunology Department, Hospital Clínic, Barcelona, and the Group of Immunoreceptors, IDIBAPS, and the Department of Cell Biology, Immunology and Neurosciences, School of Medicine, University of Barcelona. Address correspondence to Dr. M. Ramos-Casals, Servei de Malalties Autoimmunes, Hospital Clínic, C/Villarroel 170, 08036-Barcelona, Spain. E-mail: mramos@clinic.ub.es. Accepted for publication September 12, 2014.
Noelia Armiger
From the Sjögren Syndrome Research Group (AGAUR), Laboratory of Autoimmune Diseases Josep Font, Institut d’Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS); Department of Autoimmune Diseases, Department of Internal Medicine, Instituto Clínic de Medicina y Dermatología, Immunology Department, Hospital Clínic; Primary Care Research Group, Centre d’Assistència Primària ABS Les Corts, GESCLINIC; Department of Cell Biology, Immunology and Neurosciences, School of Medicine, University of Barcelona, Barcelona; Group of Immunoreceptors, Department of Internal Medicine, Hospital Infanta Leonor, Madrid; Department of Internal Medicine, Hospital do Meixoeiro, Vigo; Department of Internal Medicine, University of Cadiz, Hospital Puerta del Mar, Cádiz, Spain. Supported by Grants La Marató de TV3 (071810), Fondo de Investigaciones Sanitarias (080103/1201009), and “Ajut per a la Recerca Josep Font” from Hospital Clinic-Barcelona (PBZ, 2012). M.J. Soto-Cárdenas, MD, PhD; M. Gandía, MD, PhD, AGAUR, Laboratory of Autoimmune Diseases Josep Font, IDIBAPS, Department of Autoimmune Diseases, and the Department of Internal Medicine, University of Cadiz, Hospital Puerta del Mar; P. Brito-Zerón, MD, PhD; A. Bové, MD, PhD; S. Retamozo, MD; H. Gueitasi, MD; M. Ramos-Casals, MD, PhD, AGAUR, Laboratory of Autoimmune Diseases Josep Font, IDIBAPS, Department of Autoimmune Diseases; M.T. Arias, BSc, Immunology Department, Hospital Clínic; N. Armiger, BSc, Group of Immunoreceptors, IDIBAPS; X. Bosch, MD, PhD, Department of Internal Medicine, Instituto Clínic de Medicina y Dermatología; M. Akasbi, MD, PhD, Department of Internal Medicine, Hospital Infanta Leonor; M. Pérez-De-Lis, MD, PhD; R. Pérez-Alvarez, MD, PhD, Department of Internal Medicine, Hospital do Meixoeiro; B. Kostov, MSC; A. Siso-Almirall, MD, PhD, Primary Care Research Group, IDIBAPS, Centre d’Assistència Primària ABS Les Corts, GESCLINIC; F. Lozano, MD, PhD, Immunology Department, Hospital Clínic, Barcelona, and the Group of Immunoreceptors, IDIBAPS, and the Department of Cell Biology, Immunology and Neurosciences, School of Medicine, University of Barcelona. Address correspondence to Dr. M. Ramos-Casals, Servei de Malalties Autoimmunes, Hospital Clínic, C/Villarroel 170, 08036-Barcelona, Spain. E-mail: mramos@clinic.ub.es. Accepted for publication September 12, 2014.
Albert Bové
From the Sjögren Syndrome Research Group (AGAUR), Laboratory of Autoimmune Diseases Josep Font, Institut d’Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS); Department of Autoimmune Diseases, Department of Internal Medicine, Instituto Clínic de Medicina y Dermatología, Immunology Department, Hospital Clínic; Primary Care Research Group, Centre d’Assistència Primària ABS Les Corts, GESCLINIC; Department of Cell Biology, Immunology and Neurosciences, School of Medicine, University of Barcelona, Barcelona; Group of Immunoreceptors, Department of Internal Medicine, Hospital Infanta Leonor, Madrid; Department of Internal Medicine, Hospital do Meixoeiro, Vigo; Department of Internal Medicine, University of Cadiz, Hospital Puerta del Mar, Cádiz, Spain. Supported by Grants La Marató de TV3 (071810), Fondo de Investigaciones Sanitarias (080103/1201009), and “Ajut per a la Recerca Josep Font” from Hospital Clinic-Barcelona (PBZ, 2012). M.J. Soto-Cárdenas, MD, PhD; M. Gandía, MD, PhD, AGAUR, Laboratory of Autoimmune Diseases Josep Font, IDIBAPS, Department of Autoimmune Diseases, and the Department of Internal Medicine, University of Cadiz, Hospital Puerta del Mar; P. Brito-Zerón, MD, PhD; A. Bové, MD, PhD; S. Retamozo, MD; H. Gueitasi, MD; M. Ramos-Casals, MD, PhD, AGAUR, Laboratory of Autoimmune Diseases Josep Font, IDIBAPS, Department of Autoimmune Diseases; M.T. Arias, BSc, Immunology Department, Hospital Clínic; N. Armiger, BSc, Group of Immunoreceptors, IDIBAPS; X. Bosch, MD, PhD, Department of Internal Medicine, Instituto Clínic de Medicina y Dermatología; M. Akasbi, MD, PhD, Department of Internal Medicine, Hospital Infanta Leonor; M. Pérez-De-Lis, MD, PhD; R. Pérez-Alvarez, MD, PhD, Department of Internal Medicine, Hospital do Meixoeiro; B. Kostov, MSC; A. Siso-Almirall, MD, PhD, Primary Care Research Group, IDIBAPS, Centre d’Assistència Primària ABS Les Corts, GESCLINIC; F. Lozano, MD, PhD, Immunology Department, Hospital Clínic, Barcelona, and the Group of Immunoreceptors, IDIBAPS, and the Department of Cell Biology, Immunology and Neurosciences, School of Medicine, University of Barcelona. Address correspondence to Dr. M. Ramos-Casals, Servei de Malalties Autoimmunes, Hospital Clínic, C/Villarroel 170, 08036-Barcelona, Spain. E-mail: mramos@clinic.ub.es. Accepted for publication September 12, 2014.
Xavier Bosch
From the Sjögren Syndrome Research Group (AGAUR), Laboratory of Autoimmune Diseases Josep Font, Institut d’Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS); Department of Autoimmune Diseases, Department of Internal Medicine, Instituto Clínic de Medicina y Dermatología, Immunology Department, Hospital Clínic; Primary Care Research Group, Centre d’Assistència Primària ABS Les Corts, GESCLINIC; Department of Cell Biology, Immunology and Neurosciences, School of Medicine, University of Barcelona, Barcelona; Group of Immunoreceptors, Department of Internal Medicine, Hospital Infanta Leonor, Madrid; Department of Internal Medicine, Hospital do Meixoeiro, Vigo; Department of Internal Medicine, University of Cadiz, Hospital Puerta del Mar, Cádiz, Spain. Supported by Grants La Marató de TV3 (071810), Fondo de Investigaciones Sanitarias (080103/1201009), and “Ajut per a la Recerca Josep Font” from Hospital Clinic-Barcelona (PBZ, 2012). M.J. Soto-Cárdenas, MD, PhD; M. Gandía, MD, PhD, AGAUR, Laboratory of Autoimmune Diseases Josep Font, IDIBAPS, Department of Autoimmune Diseases, and the Department of Internal Medicine, University of Cadiz, Hospital Puerta del Mar; P. Brito-Zerón, MD, PhD; A. Bové, MD, PhD; S. Retamozo, MD; H. Gueitasi, MD; M. Ramos-Casals, MD, PhD, AGAUR, Laboratory of Autoimmune Diseases Josep Font, IDIBAPS, Department of Autoimmune Diseases; M.T. Arias, BSc, Immunology Department, Hospital Clínic; N. Armiger, BSc, Group of Immunoreceptors, IDIBAPS; X. Bosch, MD, PhD, Department of Internal Medicine, Instituto Clínic de Medicina y Dermatología; M. Akasbi, MD, PhD, Department of Internal Medicine, Hospital Infanta Leonor; M. Pérez-De-Lis, MD, PhD; R. Pérez-Alvarez, MD, PhD, Department of Internal Medicine, Hospital do Meixoeiro; B. Kostov, MSC; A. Siso-Almirall, MD, PhD, Primary Care Research Group, IDIBAPS, Centre d’Assistència Primària ABS Les Corts, GESCLINIC; F. Lozano, MD, PhD, Immunology Department, Hospital Clínic, Barcelona, and the Group of Immunoreceptors, IDIBAPS, and the Department of Cell Biology, Immunology and Neurosciences, School of Medicine, University of Barcelona. Address correspondence to Dr. M. Ramos-Casals, Servei de Malalties Autoimmunes, Hospital Clínic, C/Villarroel 170, 08036-Barcelona, Spain. E-mail: mramos@clinic.ub.es. Accepted for publication September 12, 2014.
Soledad Retamozo
From the Sjögren Syndrome Research Group (AGAUR), Laboratory of Autoimmune Diseases Josep Font, Institut d’Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS); Department of Autoimmune Diseases, Department of Internal Medicine, Instituto Clínic de Medicina y Dermatología, Immunology Department, Hospital Clínic; Primary Care Research Group, Centre d’Assistència Primària ABS Les Corts, GESCLINIC; Department of Cell Biology, Immunology and Neurosciences, School of Medicine, University of Barcelona, Barcelona; Group of Immunoreceptors, Department of Internal Medicine, Hospital Infanta Leonor, Madrid; Department of Internal Medicine, Hospital do Meixoeiro, Vigo; Department of Internal Medicine, University of Cadiz, Hospital Puerta del Mar, Cádiz, Spain. Supported by Grants La Marató de TV3 (071810), Fondo de Investigaciones Sanitarias (080103/1201009), and “Ajut per a la Recerca Josep Font” from Hospital Clinic-Barcelona (PBZ, 2012). M.J. Soto-Cárdenas, MD, PhD; M. Gandía, MD, PhD, AGAUR, Laboratory of Autoimmune Diseases Josep Font, IDIBAPS, Department of Autoimmune Diseases, and the Department of Internal Medicine, University of Cadiz, Hospital Puerta del Mar; P. Brito-Zerón, MD, PhD; A. Bové, MD, PhD; S. Retamozo, MD; H. Gueitasi, MD; M. Ramos-Casals, MD, PhD, AGAUR, Laboratory of Autoimmune Diseases Josep Font, IDIBAPS, Department of Autoimmune Diseases; M.T. Arias, BSc, Immunology Department, Hospital Clínic; N. Armiger, BSc, Group of Immunoreceptors, IDIBAPS; X. Bosch, MD, PhD, Department of Internal Medicine, Instituto Clínic de Medicina y Dermatología; M. Akasbi, MD, PhD, Department of Internal Medicine, Hospital Infanta Leonor; M. Pérez-De-Lis, MD, PhD; R. Pérez-Alvarez, MD, PhD, Department of Internal Medicine, Hospital do Meixoeiro; B. Kostov, MSC; A. Siso-Almirall, MD, PhD, Primary Care Research Group, IDIBAPS, Centre d’Assistència Primària ABS Les Corts, GESCLINIC; F. Lozano, MD, PhD, Immunology Department, Hospital Clínic, Barcelona, and the Group of Immunoreceptors, IDIBAPS, and the Department of Cell Biology, Immunology and Neurosciences, School of Medicine, University of Barcelona. Address correspondence to Dr. M. Ramos-Casals, Servei de Malalties Autoimmunes, Hospital Clínic, C/Villarroel 170, 08036-Barcelona, Spain. E-mail: mramos@clinic.ub.es. Accepted for publication September 12, 2014.
Miriam Akasbi
From the Sjögren Syndrome Research Group (AGAUR), Laboratory of Autoimmune Diseases Josep Font, Institut d’Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS); Department of Autoimmune Diseases, Department of Internal Medicine, Instituto Clínic de Medicina y Dermatología, Immunology Department, Hospital Clínic; Primary Care Research Group, Centre d’Assistència Primària ABS Les Corts, GESCLINIC; Department of Cell Biology, Immunology and Neurosciences, School of Medicine, University of Barcelona, Barcelona; Group of Immunoreceptors, Department of Internal Medicine, Hospital Infanta Leonor, Madrid; Department of Internal Medicine, Hospital do Meixoeiro, Vigo; Department of Internal Medicine, University of Cadiz, Hospital Puerta del Mar, Cádiz, Spain. Supported by Grants La Marató de TV3 (071810), Fondo de Investigaciones Sanitarias (080103/1201009), and “Ajut per a la Recerca Josep Font” from Hospital Clinic-Barcelona (PBZ, 2012). M.J. Soto-Cárdenas, MD, PhD; M. Gandía, MD, PhD, AGAUR, Laboratory of Autoimmune Diseases Josep Font, IDIBAPS, Department of Autoimmune Diseases, and the Department of Internal Medicine, University of Cadiz, Hospital Puerta del Mar; P. Brito-Zerón, MD, PhD; A. Bové, MD, PhD; S. Retamozo, MD; H. Gueitasi, MD; M. Ramos-Casals, MD, PhD, AGAUR, Laboratory of Autoimmune Diseases Josep Font, IDIBAPS, Department of Autoimmune Diseases; M.T. Arias, BSc, Immunology Department, Hospital Clínic; N. Armiger, BSc, Group of Immunoreceptors, IDIBAPS; X. Bosch, MD, PhD, Department of Internal Medicine, Instituto Clínic de Medicina y Dermatología; M. Akasbi, MD, PhD, Department of Internal Medicine, Hospital Infanta Leonor; M. Pérez-De-Lis, MD, PhD; R. Pérez-Alvarez, MD, PhD, Department of Internal Medicine, Hospital do Meixoeiro; B. Kostov, MSC; A. Siso-Almirall, MD, PhD, Primary Care Research Group, IDIBAPS, Centre d’Assistència Primària ABS Les Corts, GESCLINIC; F. Lozano, MD, PhD, Immunology Department, Hospital Clínic, Barcelona, and the Group of Immunoreceptors, IDIBAPS, and the Department of Cell Biology, Immunology and Neurosciences, School of Medicine, University of Barcelona. Address correspondence to Dr. M. Ramos-Casals, Servei de Malalties Autoimmunes, Hospital Clínic, C/Villarroel 170, 08036-Barcelona, Spain. E-mail: mramos@clinic.ub.es. Accepted for publication September 12, 2014.
Marta Pérez-De-Lis
From the Sjögren Syndrome Research Group (AGAUR), Laboratory of Autoimmune Diseases Josep Font, Institut d’Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS); Department of Autoimmune Diseases, Department of Internal Medicine, Instituto Clínic de Medicina y Dermatología, Immunology Department, Hospital Clínic; Primary Care Research Group, Centre d’Assistència Primària ABS Les Corts, GESCLINIC; Department of Cell Biology, Immunology and Neurosciences, School of Medicine, University of Barcelona, Barcelona; Group of Immunoreceptors, Department of Internal Medicine, Hospital Infanta Leonor, Madrid; Department of Internal Medicine, Hospital do Meixoeiro, Vigo; Department of Internal Medicine, University of Cadiz, Hospital Puerta del Mar, Cádiz, Spain. Supported by Grants La Marató de TV3 (071810), Fondo de Investigaciones Sanitarias (080103/1201009), and “Ajut per a la Recerca Josep Font” from Hospital Clinic-Barcelona (PBZ, 2012). M.J. Soto-Cárdenas, MD, PhD; M. Gandía, MD, PhD, AGAUR, Laboratory of Autoimmune Diseases Josep Font, IDIBAPS, Department of Autoimmune Diseases, and the Department of Internal Medicine, University of Cadiz, Hospital Puerta del Mar; P. Brito-Zerón, MD, PhD; A. Bové, MD, PhD; S. Retamozo, MD; H. Gueitasi, MD; M. Ramos-Casals, MD, PhD, AGAUR, Laboratory of Autoimmune Diseases Josep Font, IDIBAPS, Department of Autoimmune Diseases; M.T. Arias, BSc, Immunology Department, Hospital Clínic; N. Armiger, BSc, Group of Immunoreceptors, IDIBAPS; X. Bosch, MD, PhD, Department of Internal Medicine, Instituto Clínic de Medicina y Dermatología; M. Akasbi, MD, PhD, Department of Internal Medicine, Hospital Infanta Leonor; M. Pérez-De-Lis, MD, PhD; R. Pérez-Alvarez, MD, PhD, Department of Internal Medicine, Hospital do Meixoeiro; B. Kostov, MSC; A. Siso-Almirall, MD, PhD, Primary Care Research Group, IDIBAPS, Centre d’Assistència Primària ABS Les Corts, GESCLINIC; F. Lozano, MD, PhD, Immunology Department, Hospital Clínic, Barcelona, and the Group of Immunoreceptors, IDIBAPS, and the Department of Cell Biology, Immunology and Neurosciences, School of Medicine, University of Barcelona. Address correspondence to Dr. M. Ramos-Casals, Servei de Malalties Autoimmunes, Hospital Clínic, C/Villarroel 170, 08036-Barcelona, Spain. E-mail: mramos@clinic.ub.es. Accepted for publication September 12, 2014.
Hoda Gueitasi
From the Sjögren Syndrome Research Group (AGAUR), Laboratory of Autoimmune Diseases Josep Font, Institut d’Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS); Department of Autoimmune Diseases, Department of Internal Medicine, Instituto Clínic de Medicina y Dermatología, Immunology Department, Hospital Clínic; Primary Care Research Group, Centre d’Assistència Primària ABS Les Corts, GESCLINIC; Department of Cell Biology, Immunology and Neurosciences, School of Medicine, University of Barcelona, Barcelona; Group of Immunoreceptors, Department of Internal Medicine, Hospital Infanta Leonor, Madrid; Department of Internal Medicine, Hospital do Meixoeiro, Vigo; Department of Internal Medicine, University of Cadiz, Hospital Puerta del Mar, Cádiz, Spain. Supported by Grants La Marató de TV3 (071810), Fondo de Investigaciones Sanitarias (080103/1201009), and “Ajut per a la Recerca Josep Font” from Hospital Clinic-Barcelona (PBZ, 2012). M.J. Soto-Cárdenas, MD, PhD; M. Gandía, MD, PhD, AGAUR, Laboratory of Autoimmune Diseases Josep Font, IDIBAPS, Department of Autoimmune Diseases, and the Department of Internal Medicine, University of Cadiz, Hospital Puerta del Mar; P. Brito-Zerón, MD, PhD; A. Bové, MD, PhD; S. Retamozo, MD; H. Gueitasi, MD; M. Ramos-Casals, MD, PhD, AGAUR, Laboratory of Autoimmune Diseases Josep Font, IDIBAPS, Department of Autoimmune Diseases; M.T. Arias, BSc, Immunology Department, Hospital Clínic; N. Armiger, BSc, Group of Immunoreceptors, IDIBAPS; X. Bosch, MD, PhD, Department of Internal Medicine, Instituto Clínic de Medicina y Dermatología; M. Akasbi, MD, PhD, Department of Internal Medicine, Hospital Infanta Leonor; M. Pérez-De-Lis, MD, PhD; R. Pérez-Alvarez, MD, PhD, Department of Internal Medicine, Hospital do Meixoeiro; B. Kostov, MSC; A. Siso-Almirall, MD, PhD, Primary Care Research Group, IDIBAPS, Centre d’Assistència Primària ABS Les Corts, GESCLINIC; F. Lozano, MD, PhD, Immunology Department, Hospital Clínic, Barcelona, and the Group of Immunoreceptors, IDIBAPS, and the Department of Cell Biology, Immunology and Neurosciences, School of Medicine, University of Barcelona. Address correspondence to Dr. M. Ramos-Casals, Servei de Malalties Autoimmunes, Hospital Clínic, C/Villarroel 170, 08036-Barcelona, Spain. E-mail: mramos@clinic.ub.es. Accepted for publication September 12, 2014.
Belchin Kostov
From the Sjögren Syndrome Research Group (AGAUR), Laboratory of Autoimmune Diseases Josep Font, Institut d’Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS); Department of Autoimmune Diseases, Department of Internal Medicine, Instituto Clínic de Medicina y Dermatología, Immunology Department, Hospital Clínic; Primary Care Research Group, Centre d’Assistència Primària ABS Les Corts, GESCLINIC; Department of Cell Biology, Immunology and Neurosciences, School of Medicine, University of Barcelona, Barcelona; Group of Immunoreceptors, Department of Internal Medicine, Hospital Infanta Leonor, Madrid; Department of Internal Medicine, Hospital do Meixoeiro, Vigo; Department of Internal Medicine, University of Cadiz, Hospital Puerta del Mar, Cádiz, Spain. Supported by Grants La Marató de TV3 (071810), Fondo de Investigaciones Sanitarias (080103/1201009), and “Ajut per a la Recerca Josep Font” from Hospital Clinic-Barcelona (PBZ, 2012). M.J. Soto-Cárdenas, MD, PhD; M. Gandía, MD, PhD, AGAUR, Laboratory of Autoimmune Diseases Josep Font, IDIBAPS, Department of Autoimmune Diseases, and the Department of Internal Medicine, University of Cadiz, Hospital Puerta del Mar; P. Brito-Zerón, MD, PhD; A. Bové, MD, PhD; S. Retamozo, MD; H. Gueitasi, MD; M. Ramos-Casals, MD, PhD, AGAUR, Laboratory of Autoimmune Diseases Josep Font, IDIBAPS, Department of Autoimmune Diseases; M.T. Arias, BSc, Immunology Department, Hospital Clínic; N. Armiger, BSc, Group of Immunoreceptors, IDIBAPS; X. Bosch, MD, PhD, Department of Internal Medicine, Instituto Clínic de Medicina y Dermatología; M. Akasbi, MD, PhD, Department of Internal Medicine, Hospital Infanta Leonor; M. Pérez-De-Lis, MD, PhD; R. Pérez-Alvarez, MD, PhD, Department of Internal Medicine, Hospital do Meixoeiro; B. Kostov, MSC; A. Siso-Almirall, MD, PhD, Primary Care Research Group, IDIBAPS, Centre d’Assistència Primària ABS Les Corts, GESCLINIC; F. Lozano, MD, PhD, Immunology Department, Hospital Clínic, Barcelona, and the Group of Immunoreceptors, IDIBAPS, and the Department of Cell Biology, Immunology and Neurosciences, School of Medicine, University of Barcelona. Address correspondence to Dr. M. Ramos-Casals, Servei de Malalties Autoimmunes, Hospital Clínic, C/Villarroel 170, 08036-Barcelona, Spain. E-mail: mramos@clinic.ub.es. Accepted for publication September 12, 2014.
Roberto Pérez-Alvarez
From the Sjögren Syndrome Research Group (AGAUR), Laboratory of Autoimmune Diseases Josep Font, Institut d’Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS); Department of Autoimmune Diseases, Department of Internal Medicine, Instituto Clínic de Medicina y Dermatología, Immunology Department, Hospital Clínic; Primary Care Research Group, Centre d’Assistència Primària ABS Les Corts, GESCLINIC; Department of Cell Biology, Immunology and Neurosciences, School of Medicine, University of Barcelona, Barcelona; Group of Immunoreceptors, Department of Internal Medicine, Hospital Infanta Leonor, Madrid; Department of Internal Medicine, Hospital do Meixoeiro, Vigo; Department of Internal Medicine, University of Cadiz, Hospital Puerta del Mar, Cádiz, Spain. Supported by Grants La Marató de TV3 (071810), Fondo de Investigaciones Sanitarias (080103/1201009), and “Ajut per a la Recerca Josep Font” from Hospital Clinic-Barcelona (PBZ, 2012). M.J. Soto-Cárdenas, MD, PhD; M. Gandía, MD, PhD, AGAUR, Laboratory of Autoimmune Diseases Josep Font, IDIBAPS, Department of Autoimmune Diseases, and the Department of Internal Medicine, University of Cadiz, Hospital Puerta del Mar; P. Brito-Zerón, MD, PhD; A. Bové, MD, PhD; S. Retamozo, MD; H. Gueitasi, MD; M. Ramos-Casals, MD, PhD, AGAUR, Laboratory of Autoimmune Diseases Josep Font, IDIBAPS, Department of Autoimmune Diseases; M.T. Arias, BSc, Immunology Department, Hospital Clínic; N. Armiger, BSc, Group of Immunoreceptors, IDIBAPS; X. Bosch, MD, PhD, Department of Internal Medicine, Instituto Clínic de Medicina y Dermatología; M. Akasbi, MD, PhD, Department of Internal Medicine, Hospital Infanta Leonor; M. Pérez-De-Lis, MD, PhD; R. Pérez-Alvarez, MD, PhD, Department of Internal Medicine, Hospital do Meixoeiro; B. Kostov, MSC; A. Siso-Almirall, MD, PhD, Primary Care Research Group, IDIBAPS, Centre d’Assistència Primària ABS Les Corts, GESCLINIC; F. Lozano, MD, PhD, Immunology Department, Hospital Clínic, Barcelona, and the Group of Immunoreceptors, IDIBAPS, and the Department of Cell Biology, Immunology and Neurosciences, School of Medicine, University of Barcelona. Address correspondence to Dr. M. Ramos-Casals, Servei de Malalties Autoimmunes, Hospital Clínic, C/Villarroel 170, 08036-Barcelona, Spain. E-mail: mramos@clinic.ub.es. Accepted for publication September 12, 2014.
Antoni Siso-Almirall
From the Sjögren Syndrome Research Group (AGAUR), Laboratory of Autoimmune Diseases Josep Font, Institut d’Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS); Department of Autoimmune Diseases, Department of Internal Medicine, Instituto Clínic de Medicina y Dermatología, Immunology Department, Hospital Clínic; Primary Care Research Group, Centre d’Assistència Primària ABS Les Corts, GESCLINIC; Department of Cell Biology, Immunology and Neurosciences, School of Medicine, University of Barcelona, Barcelona; Group of Immunoreceptors, Department of Internal Medicine, Hospital Infanta Leonor, Madrid; Department of Internal Medicine, Hospital do Meixoeiro, Vigo; Department of Internal Medicine, University of Cadiz, Hospital Puerta del Mar, Cádiz, Spain. Supported by Grants La Marató de TV3 (071810), Fondo de Investigaciones Sanitarias (080103/1201009), and “Ajut per a la Recerca Josep Font” from Hospital Clinic-Barcelona (PBZ, 2012). M.J. Soto-Cárdenas, MD, PhD; M. Gandía, MD, PhD, AGAUR, Laboratory of Autoimmune Diseases Josep Font, IDIBAPS, Department of Autoimmune Diseases, and the Department of Internal Medicine, University of Cadiz, Hospital Puerta del Mar; P. Brito-Zerón, MD, PhD; A. Bové, MD, PhD; S. Retamozo, MD; H. Gueitasi, MD; M. Ramos-Casals, MD, PhD, AGAUR, Laboratory of Autoimmune Diseases Josep Font, IDIBAPS, Department of Autoimmune Diseases; M.T. Arias, BSc, Immunology Department, Hospital Clínic; N. Armiger, BSc, Group of Immunoreceptors, IDIBAPS; X. Bosch, MD, PhD, Department of Internal Medicine, Instituto Clínic de Medicina y Dermatología; M. Akasbi, MD, PhD, Department of Internal Medicine, Hospital Infanta Leonor; M. Pérez-De-Lis, MD, PhD; R. Pérez-Alvarez, MD, PhD, Department of Internal Medicine, Hospital do Meixoeiro; B. Kostov, MSC; A. Siso-Almirall, MD, PhD, Primary Care Research Group, IDIBAPS, Centre d’Assistència Primària ABS Les Corts, GESCLINIC; F. Lozano, MD, PhD, Immunology Department, Hospital Clínic, Barcelona, and the Group of Immunoreceptors, IDIBAPS, and the Department of Cell Biology, Immunology and Neurosciences, School of Medicine, University of Barcelona. Address correspondence to Dr. M. Ramos-Casals, Servei de Malalties Autoimmunes, Hospital Clínic, C/Villarroel 170, 08036-Barcelona, Spain. E-mail: mramos@clinic.ub.es. Accepted for publication September 12, 2014.
Francisco Lozano
From the Sjögren Syndrome Research Group (AGAUR), Laboratory of Autoimmune Diseases Josep Font, Institut d’Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS); Department of Autoimmune Diseases, Department of Internal Medicine, Instituto Clínic de Medicina y Dermatología, Immunology Department, Hospital Clínic; Primary Care Research Group, Centre d’Assistència Primària ABS Les Corts, GESCLINIC; Department of Cell Biology, Immunology and Neurosciences, School of Medicine, University of Barcelona, Barcelona; Group of Immunoreceptors, Department of Internal Medicine, Hospital Infanta Leonor, Madrid; Department of Internal Medicine, Hospital do Meixoeiro, Vigo; Department of Internal Medicine, University of Cadiz, Hospital Puerta del Mar, Cádiz, Spain. Supported by Grants La Marató de TV3 (071810), Fondo de Investigaciones Sanitarias (080103/1201009), and “Ajut per a la Recerca Josep Font” from Hospital Clinic-Barcelona (PBZ, 2012). M.J. Soto-Cárdenas, MD, PhD; M. Gandía, MD, PhD, AGAUR, Laboratory of Autoimmune Diseases Josep Font, IDIBAPS, Department of Autoimmune Diseases, and the Department of Internal Medicine, University of Cadiz, Hospital Puerta del Mar; P. Brito-Zerón, MD, PhD; A. Bové, MD, PhD; S. Retamozo, MD; H. Gueitasi, MD; M. Ramos-Casals, MD, PhD, AGAUR, Laboratory of Autoimmune Diseases Josep Font, IDIBAPS, Department of Autoimmune Diseases; M.T. Arias, BSc, Immunology Department, Hospital Clínic; N. Armiger, BSc, Group of Immunoreceptors, IDIBAPS; X. Bosch, MD, PhD, Department of Internal Medicine, Instituto Clínic de Medicina y Dermatología; M. Akasbi, MD, PhD, Department of Internal Medicine, Hospital Infanta Leonor; M. Pérez-De-Lis, MD, PhD; R. Pérez-Alvarez, MD, PhD, Department of Internal Medicine, Hospital do Meixoeiro; B. Kostov, MSC; A. Siso-Almirall, MD, PhD, Primary Care Research Group, IDIBAPS, Centre d’Assistència Primària ABS Les Corts, GESCLINIC; F. Lozano, MD, PhD, Immunology Department, Hospital Clínic, Barcelona, and the Group of Immunoreceptors, IDIBAPS, and the Department of Cell Biology, Immunology and Neurosciences, School of Medicine, University of Barcelona. Address correspondence to Dr. M. Ramos-Casals, Servei de Malalties Autoimmunes, Hospital Clínic, C/Villarroel 170, 08036-Barcelona, Spain. E-mail: mramos@clinic.ub.es. Accepted for publication September 12, 2014.
Manuel Ramos-Casals
From the Sjögren Syndrome Research Group (AGAUR), Laboratory of Autoimmune Diseases Josep Font, Institut d’Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS); Department of Autoimmune Diseases, Department of Internal Medicine, Instituto Clínic de Medicina y Dermatología, Immunology Department, Hospital Clínic; Primary Care Research Group, Centre d’Assistència Primària ABS Les Corts, GESCLINIC; Department of Cell Biology, Immunology and Neurosciences, School of Medicine, University of Barcelona, Barcelona; Group of Immunoreceptors, Department of Internal Medicine, Hospital Infanta Leonor, Madrid; Department of Internal Medicine, Hospital do Meixoeiro, Vigo; Department of Internal Medicine, University of Cadiz, Hospital Puerta del Mar, Cádiz, Spain. Supported by Grants La Marató de TV3 (071810), Fondo de Investigaciones Sanitarias (080103/1201009), and “Ajut per a la Recerca Josep Font” from Hospital Clinic-Barcelona (PBZ, 2012). M.J. Soto-Cárdenas, MD, PhD; M. Gandía, MD, PhD, AGAUR, Laboratory of Autoimmune Diseases Josep Font, IDIBAPS, Department of Autoimmune Diseases, and the Department of Internal Medicine, University of Cadiz, Hospital Puerta del Mar; P. Brito-Zerón, MD, PhD; A. Bové, MD, PhD; S. Retamozo, MD; H. Gueitasi, MD; M. Ramos-Casals, MD, PhD, AGAUR, Laboratory of Autoimmune Diseases Josep Font, IDIBAPS, Department of Autoimmune Diseases; M.T. Arias, BSc, Immunology Department, Hospital Clínic; N. Armiger, BSc, Group of Immunoreceptors, IDIBAPS; X. Bosch, MD, PhD, Department of Internal Medicine, Instituto Clínic de Medicina y Dermatología; M. Akasbi, MD, PhD, Department of Internal Medicine, Hospital Infanta Leonor; M. Pérez-De-Lis, MD, PhD; R. Pérez-Alvarez, MD, PhD, Department of Internal Medicine, Hospital do Meixoeiro; B. Kostov, MSC; A. Siso-Almirall, MD, PhD, Primary Care Research Group, IDIBAPS, Centre d’Assistència Primària ABS Les Corts, GESCLINIC; F. Lozano, MD, PhD, Immunology Department, Hospital Clínic, Barcelona, and the Group of Immunoreceptors, IDIBAPS, and the Department of Cell Biology, Immunology and Neurosciences, School of Medicine, University of Barcelona. Address correspondence to Dr. M. Ramos-Casals, Servei de Malalties Autoimmunes, Hospital Clínic, C/Villarroel 170, 08036-Barcelona, Spain. E-mail: mramos@clinic.ub.es. Accepted for publication September 12, 2014.
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© 2014 The Journal of Rheumatology
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- María José Soto-Cárdenas,
- Myriam Gandía,
- Pilar Brito-Zerón,
- Maria Teresa Arias,
- Noelia Armiger,
- Albert Bové,
- Xavier Bosch,
- Soledad Retamozo,
- Miriam Akasbi,
- Marta Pérez-De-Lis,
- Hoda Gueitasi,
- Belchin Kostov,
- Roberto Pérez-Alvarez,
- Antoni Siso-Almirall,
- Francisco Lozano and
- Manuel Ramos-Casals
- From the Sjögren Syndrome Research Group (AGAUR), Laboratory of Autoimmune Diseases Josep Font, Institut d’Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS); Department of Autoimmune Diseases, Department of Internal Medicine, Instituto Clínic de Medicina y Dermatología, Immunology Department, Hospital Clínic; Primary Care Research Group, Centre d’Assistència Primària ABS Les Corts, GESCLINIC; Department of Cell Biology, Immunology and Neurosciences, School of Medicine, University of Barcelona, Barcelona; Group of Immunoreceptors, Department of Internal Medicine, Hospital Infanta Leonor, Madrid; Department of Internal Medicine, Hospital do Meixoeiro, Vigo; Department of Internal Medicine, University of Cadiz, Hospital Puerta del Mar, Cádiz, Spain.
Supported by Grants La Marató de TV3 (071810), Fondo de Investigaciones Sanitarias (080103/1201009), and “Ajut per a la Recerca Josep Font” from Hospital Clinic-Barcelona (PBZ, 2012). M.J. Soto-Cárdenas, MD, PhD; M. Gandía, MD, PhD, AGAUR, Laboratory of Autoimmune Diseases Josep Font, IDIBAPS, Department of Autoimmune Diseases, and the Department of Internal Medicine, University of Cadiz, Hospital Puerta del Mar; P. Brito-Zerón, MD, PhD; A. Bové, MD, PhD; S. Retamozo, MD; H. Gueitasi, MD; M. Ramos-Casals, MD, PhD, AGAUR, Laboratory of Autoimmune Diseases Josep Font, IDIBAPS, Department of Autoimmune Diseases; M.T. Arias, BSc, Immunology Department, Hospital Clínic; N. Armiger, BSc, Group of Immunoreceptors, IDIBAPS; X. Bosch, MD, PhD, Department of Internal Medicine, Instituto Clínic de Medicina y Dermatología; M. Akasbi, MD, PhD, Department of Internal Medicine, Hospital Infanta Leonor; M. Pérez-De-Lis, MD, PhD; R. Pérez-Alvarez, MD, PhD, Department of Internal Medicine, Hospital do Meixoeiro; B. Kostov, MSC; A. Siso-Almirall, MD, PhD, Primary Care Research Group, IDIBAPS, Centre d’Assistència Primària ABS Les Corts, GESCLINIC; F. Lozano, MD, PhD, Immunology Department, Hospital Clínic, Barcelona, and the Group of Immunoreceptors, IDIBAPS, and the Department of Cell Biology, Immunology and Neurosciences, School of Medicine, University of Barcelona.
Address correspondence to Dr. M. Ramos-Casals, Servei de Malalties Autoimmunes, Hospital Clínic, C/Villarroel 170, 08036-Barcelona, Spain. E-mail: mramos@clinic.ub.es.
Accepted for publication September 12, 2014.
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The Journal of Rheumatology
Vol. 51, Issue 3
1 Mar 2024
Etiopathogenic Role of Surfactant Protein D in the Clinical and Immunological Expression of Primary Sjögren Syndrome
María José Soto-Cárdenas, Myriam Gandía, Pilar Brito-Zerón, Maria Teresa Arias, Noelia Armiger, Albert Bové, Xavier Bosch, Soledad Retamozo, Miriam Akasbi, Marta Pérez-De-Lis, Hoda Gueitasi, Belchin Kostov, Roberto Pérez-Alvarez, Antoni Siso-Almirall, Francisco Lozano, Manuel Ramos-Casals
The Journal of Rheumatology Nov 2014, jrheum.140394; DOI: 10.3899/jrheum.140394
Etiopathogenic Role of Surfactant Protein D in the Clinical and Immunological Expression of Primary Sjögren Syndrome
María José Soto-Cárdenas, Myriam Gandía, Pilar Brito-Zerón, Maria Teresa Arias, Noelia Armiger, Albert Bové, Xavier Bosch, Soledad Retamozo, Miriam Akasbi, Marta Pérez-De-Lis, Hoda Gueitasi, Belchin Kostov, Roberto Pérez-Alvarez, Antoni Siso-Almirall, Francisco Lozano, Manuel Ramos-Casals
The Journal of Rheumatology Nov 2014, jrheum.140394; DOI: 10.3899/jrheum.140394