Research ArticleArticle
Role of Fractalkine in the Pathogenesis of Primary Sjögren Syndrome: Increased Serum Levels of Fractalkine, Its Expression in Labial Salivary Glands, and the Association with Clinical Manifestations
Jae Ho Lee, Seung-Ki Kwok, Seung Min Jung, Jennifer Lee, Jae-Seon Lee, Seung Ye Baek, Eun-Kyung Kim, Ji Hyeon Ju, Sung-Hwan Park and Ho-Youn Kim
The Journal of Rheumatology October 2014, jrheum.130892; DOI: https://doi.org/10.3899/jrheum.130892
Jae Ho Lee
From the Division of Rheumatology, Department of Internal Medicine, School of Medicine, and the Rheumatism Research Center, The Catholic University of Korea, Seoul, South Korea. Supported by Basic Science Research Program through the National Research Foundation of Korea, funded by the Ministry of Education, Science, and Technology (Grant number: 2005-0048480 and 2010-0023010). J.H. Lee, MD, Bachelor’s degree, Appointment Physician, Rheumatology Specialist, Fellow; S-K. Kwok, MD, PhD, Appointment Physician, Rheumatology Specialist, Associate Professor; S.M. Jung, MD, Bachelor’s degree, Appointment Physician, Rheumatology Specialist, Fellow; J. Lee, MD, Bachelor’s degree, Appointment Physician, Rheumatology Specialist, Fellow; J.H. Ju, MD, PhD, Appointment Physician, Rheumatology Specialist, Associate Professor; S-H. Park, MD, PhD, Appointment Physician, Rheumatology Specialist, Professor; H-Y. Kim, MD, PhD, Appointment Physician, Rheumatology Specialist, Professor, Division of Rheumatology, Department of Internal Medicine, School of Medicine; J-S. Lee, Master’s degree, Appointment Researcher; S.Y. Baek, Bachelor’s degree, Appointment Researcher; E-K. Kim, Bachelor’s degree, Appointment Researcher, Rheumatism Research Center, The Catholic University of Korea. Address correspondence to Dr. S-K. Kwok, Division of Rheumatology, Department of Internal Medicine, School of Medicine, The Catholic University of Korea, Seoul St. Mary’s Hospital, 222 Banpodaero, Seocho-Gu, Seoul 137-040, South Korea. E-mail: seungki73@catholic.ac.kr. Accepted for publication August 27, 2014.
Seung-Ki Kwok
From the Division of Rheumatology, Department of Internal Medicine, School of Medicine, and the Rheumatism Research Center, The Catholic University of Korea, Seoul, South Korea. Supported by Basic Science Research Program through the National Research Foundation of Korea, funded by the Ministry of Education, Science, and Technology (Grant number: 2005-0048480 and 2010-0023010). J.H. Lee, MD, Bachelor’s degree, Appointment Physician, Rheumatology Specialist, Fellow; S-K. Kwok, MD, PhD, Appointment Physician, Rheumatology Specialist, Associate Professor; S.M. Jung, MD, Bachelor’s degree, Appointment Physician, Rheumatology Specialist, Fellow; J. Lee, MD, Bachelor’s degree, Appointment Physician, Rheumatology Specialist, Fellow; J.H. Ju, MD, PhD, Appointment Physician, Rheumatology Specialist, Associate Professor; S-H. Park, MD, PhD, Appointment Physician, Rheumatology Specialist, Professor; H-Y. Kim, MD, PhD, Appointment Physician, Rheumatology Specialist, Professor, Division of Rheumatology, Department of Internal Medicine, School of Medicine; J-S. Lee, Master’s degree, Appointment Researcher; S.Y. Baek, Bachelor’s degree, Appointment Researcher; E-K. Kim, Bachelor’s degree, Appointment Researcher, Rheumatism Research Center, The Catholic University of Korea. Address correspondence to Dr. S-K. Kwok, Division of Rheumatology, Department of Internal Medicine, School of Medicine, The Catholic University of Korea, Seoul St. Mary’s Hospital, 222 Banpodaero, Seocho-Gu, Seoul 137-040, South Korea. E-mail: seungki73@catholic.ac.kr. Accepted for publication August 27, 2014.
Seung Min Jung
From the Division of Rheumatology, Department of Internal Medicine, School of Medicine, and the Rheumatism Research Center, The Catholic University of Korea, Seoul, South Korea. Supported by Basic Science Research Program through the National Research Foundation of Korea, funded by the Ministry of Education, Science, and Technology (Grant number: 2005-0048480 and 2010-0023010). J.H. Lee, MD, Bachelor’s degree, Appointment Physician, Rheumatology Specialist, Fellow; S-K. Kwok, MD, PhD, Appointment Physician, Rheumatology Specialist, Associate Professor; S.M. Jung, MD, Bachelor’s degree, Appointment Physician, Rheumatology Specialist, Fellow; J. Lee, MD, Bachelor’s degree, Appointment Physician, Rheumatology Specialist, Fellow; J.H. Ju, MD, PhD, Appointment Physician, Rheumatology Specialist, Associate Professor; S-H. Park, MD, PhD, Appointment Physician, Rheumatology Specialist, Professor; H-Y. Kim, MD, PhD, Appointment Physician, Rheumatology Specialist, Professor, Division of Rheumatology, Department of Internal Medicine, School of Medicine; J-S. Lee, Master’s degree, Appointment Researcher; S.Y. Baek, Bachelor’s degree, Appointment Researcher; E-K. Kim, Bachelor’s degree, Appointment Researcher, Rheumatism Research Center, The Catholic University of Korea. Address correspondence to Dr. S-K. Kwok, Division of Rheumatology, Department of Internal Medicine, School of Medicine, The Catholic University of Korea, Seoul St. Mary’s Hospital, 222 Banpodaero, Seocho-Gu, Seoul 137-040, South Korea. E-mail: seungki73@catholic.ac.kr. Accepted for publication August 27, 2014.
Jennifer Lee
From the Division of Rheumatology, Department of Internal Medicine, School of Medicine, and the Rheumatism Research Center, The Catholic University of Korea, Seoul, South Korea. Supported by Basic Science Research Program through the National Research Foundation of Korea, funded by the Ministry of Education, Science, and Technology (Grant number: 2005-0048480 and 2010-0023010). J.H. Lee, MD, Bachelor’s degree, Appointment Physician, Rheumatology Specialist, Fellow; S-K. Kwok, MD, PhD, Appointment Physician, Rheumatology Specialist, Associate Professor; S.M. Jung, MD, Bachelor’s degree, Appointment Physician, Rheumatology Specialist, Fellow; J. Lee, MD, Bachelor’s degree, Appointment Physician, Rheumatology Specialist, Fellow; J.H. Ju, MD, PhD, Appointment Physician, Rheumatology Specialist, Associate Professor; S-H. Park, MD, PhD, Appointment Physician, Rheumatology Specialist, Professor; H-Y. Kim, MD, PhD, Appointment Physician, Rheumatology Specialist, Professor, Division of Rheumatology, Department of Internal Medicine, School of Medicine; J-S. Lee, Master’s degree, Appointment Researcher; S.Y. Baek, Bachelor’s degree, Appointment Researcher; E-K. Kim, Bachelor’s degree, Appointment Researcher, Rheumatism Research Center, The Catholic University of Korea. Address correspondence to Dr. S-K. Kwok, Division of Rheumatology, Department of Internal Medicine, School of Medicine, The Catholic University of Korea, Seoul St. Mary’s Hospital, 222 Banpodaero, Seocho-Gu, Seoul 137-040, South Korea. E-mail: seungki73@catholic.ac.kr. Accepted for publication August 27, 2014.
Jae-Seon Lee
From the Division of Rheumatology, Department of Internal Medicine, School of Medicine, and the Rheumatism Research Center, The Catholic University of Korea, Seoul, South Korea. Supported by Basic Science Research Program through the National Research Foundation of Korea, funded by the Ministry of Education, Science, and Technology (Grant number: 2005-0048480 and 2010-0023010). J.H. Lee, MD, Bachelor’s degree, Appointment Physician, Rheumatology Specialist, Fellow; S-K. Kwok, MD, PhD, Appointment Physician, Rheumatology Specialist, Associate Professor; S.M. Jung, MD, Bachelor’s degree, Appointment Physician, Rheumatology Specialist, Fellow; J. Lee, MD, Bachelor’s degree, Appointment Physician, Rheumatology Specialist, Fellow; J.H. Ju, MD, PhD, Appointment Physician, Rheumatology Specialist, Associate Professor; S-H. Park, MD, PhD, Appointment Physician, Rheumatology Specialist, Professor; H-Y. Kim, MD, PhD, Appointment Physician, Rheumatology Specialist, Professor, Division of Rheumatology, Department of Internal Medicine, School of Medicine; J-S. Lee, Master’s degree, Appointment Researcher; S.Y. Baek, Bachelor’s degree, Appointment Researcher; E-K. Kim, Bachelor’s degree, Appointment Researcher, Rheumatism Research Center, The Catholic University of Korea. Address correspondence to Dr. S-K. Kwok, Division of Rheumatology, Department of Internal Medicine, School of Medicine, The Catholic University of Korea, Seoul St. Mary’s Hospital, 222 Banpodaero, Seocho-Gu, Seoul 137-040, South Korea. E-mail: seungki73@catholic.ac.kr. Accepted for publication August 27, 2014.
Seung Ye Baek
From the Division of Rheumatology, Department of Internal Medicine, School of Medicine, and the Rheumatism Research Center, The Catholic University of Korea, Seoul, South Korea. Supported by Basic Science Research Program through the National Research Foundation of Korea, funded by the Ministry of Education, Science, and Technology (Grant number: 2005-0048480 and 2010-0023010). J.H. Lee, MD, Bachelor’s degree, Appointment Physician, Rheumatology Specialist, Fellow; S-K. Kwok, MD, PhD, Appointment Physician, Rheumatology Specialist, Associate Professor; S.M. Jung, MD, Bachelor’s degree, Appointment Physician, Rheumatology Specialist, Fellow; J. Lee, MD, Bachelor’s degree, Appointment Physician, Rheumatology Specialist, Fellow; J.H. Ju, MD, PhD, Appointment Physician, Rheumatology Specialist, Associate Professor; S-H. Park, MD, PhD, Appointment Physician, Rheumatology Specialist, Professor; H-Y. Kim, MD, PhD, Appointment Physician, Rheumatology Specialist, Professor, Division of Rheumatology, Department of Internal Medicine, School of Medicine; J-S. Lee, Master’s degree, Appointment Researcher; S.Y. Baek, Bachelor’s degree, Appointment Researcher; E-K. Kim, Bachelor’s degree, Appointment Researcher, Rheumatism Research Center, The Catholic University of Korea. Address correspondence to Dr. S-K. Kwok, Division of Rheumatology, Department of Internal Medicine, School of Medicine, The Catholic University of Korea, Seoul St. Mary’s Hospital, 222 Banpodaero, Seocho-Gu, Seoul 137-040, South Korea. E-mail: seungki73@catholic.ac.kr. Accepted for publication August 27, 2014.
Eun-Kyung Kim
From the Division of Rheumatology, Department of Internal Medicine, School of Medicine, and the Rheumatism Research Center, The Catholic University of Korea, Seoul, South Korea. Supported by Basic Science Research Program through the National Research Foundation of Korea, funded by the Ministry of Education, Science, and Technology (Grant number: 2005-0048480 and 2010-0023010). J.H. Lee, MD, Bachelor’s degree, Appointment Physician, Rheumatology Specialist, Fellow; S-K. Kwok, MD, PhD, Appointment Physician, Rheumatology Specialist, Associate Professor; S.M. Jung, MD, Bachelor’s degree, Appointment Physician, Rheumatology Specialist, Fellow; J. Lee, MD, Bachelor’s degree, Appointment Physician, Rheumatology Specialist, Fellow; J.H. Ju, MD, PhD, Appointment Physician, Rheumatology Specialist, Associate Professor; S-H. Park, MD, PhD, Appointment Physician, Rheumatology Specialist, Professor; H-Y. Kim, MD, PhD, Appointment Physician, Rheumatology Specialist, Professor, Division of Rheumatology, Department of Internal Medicine, School of Medicine; J-S. Lee, Master’s degree, Appointment Researcher; S.Y. Baek, Bachelor’s degree, Appointment Researcher; E-K. Kim, Bachelor’s degree, Appointment Researcher, Rheumatism Research Center, The Catholic University of Korea. Address correspondence to Dr. S-K. Kwok, Division of Rheumatology, Department of Internal Medicine, School of Medicine, The Catholic University of Korea, Seoul St. Mary’s Hospital, 222 Banpodaero, Seocho-Gu, Seoul 137-040, South Korea. E-mail: seungki73@catholic.ac.kr. Accepted for publication August 27, 2014.
Ji Hyeon Ju
From the Division of Rheumatology, Department of Internal Medicine, School of Medicine, and the Rheumatism Research Center, The Catholic University of Korea, Seoul, South Korea. Supported by Basic Science Research Program through the National Research Foundation of Korea, funded by the Ministry of Education, Science, and Technology (Grant number: 2005-0048480 and 2010-0023010). J.H. Lee, MD, Bachelor’s degree, Appointment Physician, Rheumatology Specialist, Fellow; S-K. Kwok, MD, PhD, Appointment Physician, Rheumatology Specialist, Associate Professor; S.M. Jung, MD, Bachelor’s degree, Appointment Physician, Rheumatology Specialist, Fellow; J. Lee, MD, Bachelor’s degree, Appointment Physician, Rheumatology Specialist, Fellow; J.H. Ju, MD, PhD, Appointment Physician, Rheumatology Specialist, Associate Professor; S-H. Park, MD, PhD, Appointment Physician, Rheumatology Specialist, Professor; H-Y. Kim, MD, PhD, Appointment Physician, Rheumatology Specialist, Professor, Division of Rheumatology, Department of Internal Medicine, School of Medicine; J-S. Lee, Master’s degree, Appointment Researcher; S.Y. Baek, Bachelor’s degree, Appointment Researcher; E-K. Kim, Bachelor’s degree, Appointment Researcher, Rheumatism Research Center, The Catholic University of Korea. Address correspondence to Dr. S-K. Kwok, Division of Rheumatology, Department of Internal Medicine, School of Medicine, The Catholic University of Korea, Seoul St. Mary’s Hospital, 222 Banpodaero, Seocho-Gu, Seoul 137-040, South Korea. E-mail: seungki73@catholic.ac.kr. Accepted for publication August 27, 2014.
Sung-Hwan Park
From the Division of Rheumatology, Department of Internal Medicine, School of Medicine, and the Rheumatism Research Center, The Catholic University of Korea, Seoul, South Korea. Supported by Basic Science Research Program through the National Research Foundation of Korea, funded by the Ministry of Education, Science, and Technology (Grant number: 2005-0048480 and 2010-0023010). J.H. Lee, MD, Bachelor’s degree, Appointment Physician, Rheumatology Specialist, Fellow; S-K. Kwok, MD, PhD, Appointment Physician, Rheumatology Specialist, Associate Professor; S.M. Jung, MD, Bachelor’s degree, Appointment Physician, Rheumatology Specialist, Fellow; J. Lee, MD, Bachelor’s degree, Appointment Physician, Rheumatology Specialist, Fellow; J.H. Ju, MD, PhD, Appointment Physician, Rheumatology Specialist, Associate Professor; S-H. Park, MD, PhD, Appointment Physician, Rheumatology Specialist, Professor; H-Y. Kim, MD, PhD, Appointment Physician, Rheumatology Specialist, Professor, Division of Rheumatology, Department of Internal Medicine, School of Medicine; J-S. Lee, Master’s degree, Appointment Researcher; S.Y. Baek, Bachelor’s degree, Appointment Researcher; E-K. Kim, Bachelor’s degree, Appointment Researcher, Rheumatism Research Center, The Catholic University of Korea. Address correspondence to Dr. S-K. Kwok, Division of Rheumatology, Department of Internal Medicine, School of Medicine, The Catholic University of Korea, Seoul St. Mary’s Hospital, 222 Banpodaero, Seocho-Gu, Seoul 137-040, South Korea. E-mail: seungki73@catholic.ac.kr. Accepted for publication August 27, 2014.
Ho-Youn Kim
From the Division of Rheumatology, Department of Internal Medicine, School of Medicine, and the Rheumatism Research Center, The Catholic University of Korea, Seoul, South Korea. Supported by Basic Science Research Program through the National Research Foundation of Korea, funded by the Ministry of Education, Science, and Technology (Grant number: 2005-0048480 and 2010-0023010). J.H. Lee, MD, Bachelor’s degree, Appointment Physician, Rheumatology Specialist, Fellow; S-K. Kwok, MD, PhD, Appointment Physician, Rheumatology Specialist, Associate Professor; S.M. Jung, MD, Bachelor’s degree, Appointment Physician, Rheumatology Specialist, Fellow; J. Lee, MD, Bachelor’s degree, Appointment Physician, Rheumatology Specialist, Fellow; J.H. Ju, MD, PhD, Appointment Physician, Rheumatology Specialist, Associate Professor; S-H. Park, MD, PhD, Appointment Physician, Rheumatology Specialist, Professor; H-Y. Kim, MD, PhD, Appointment Physician, Rheumatology Specialist, Professor, Division of Rheumatology, Department of Internal Medicine, School of Medicine; J-S. Lee, Master’s degree, Appointment Researcher; S.Y. Baek, Bachelor’s degree, Appointment Researcher; E-K. Kim, Bachelor’s degree, Appointment Researcher, Rheumatism Research Center, The Catholic University of Korea. Address correspondence to Dr. S-K. Kwok, Division of Rheumatology, Department of Internal Medicine, School of Medicine, The Catholic University of Korea, Seoul St. Mary’s Hospital, 222 Banpodaero, Seocho-Gu, Seoul 137-040, South Korea. E-mail: seungki73@catholic.ac.kr. Accepted for publication August 27, 2014.
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In this issue
The Journal of Rheumatology
Vol. 51, Issue 4
1 Apr 2024
Role of Fractalkine in the Pathogenesis of Primary Sjögren Syndrome: Increased Serum Levels of Fractalkine, Its Expression in Labial Salivary Glands, and the Association with Clinical Manifestations
Jae Ho Lee, Seung-Ki Kwok, Seung Min Jung, Jennifer Lee, Jae-Seon Lee, Seung Ye Baek, Eun-Kyung Kim, Ji Hyeon Ju, Sung-Hwan Park, Ho-Youn Kim
The Journal of Rheumatology Oct 2014, jrheum.130892; DOI: 10.3899/jrheum.130892
Role of Fractalkine in the Pathogenesis of Primary Sjögren Syndrome: Increased Serum Levels of Fractalkine, Its Expression in Labial Salivary Glands, and the Association with Clinical Manifestations
Jae Ho Lee, Seung-Ki Kwok, Seung Min Jung, Jennifer Lee, Jae-Seon Lee, Seung Ye Baek, Eun-Kyung Kim, Ji Hyeon Ju, Sung-Hwan Park, Ho-Youn Kim
The Journal of Rheumatology Oct 2014, jrheum.130892; DOI: 10.3899/jrheum.130892